René H. Wijffels - Publications

Bioprocess Engineering Wageningen University, Wageningen, Gelderland, Netherlands 

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hesp K, van der Heijden JME, Munroe S, Sipkema D, Martens DE, Wijffels RH, Pomponi SA. First continuous marine sponge cell line established. Scientific Reports. 13: 5766. PMID 37031251 DOI: 10.1038/s41598-023-32394-x  0.606
2020 Gutleben J, Koehorst JJ, McPherson K, Pomponi S, Wijffels RH, Smidt H, Sipkema D. Diversity of tryptophan halogenases in sponges of the genus Aplysina. Fems Microbiology Ecology. 95. PMID 31276591 DOI: 10.1093/femsec/fiz108  0.525
2019 Conkling M, Hesp K, Munroe S, Sandoval K, Martens DE, Sipkema D, Wijffels RH, Pomponi SA. Breakthrough in Marine Invertebrate Cell Culture: Sponge Cells Divide Rapidly in Improved Nutrient Medium. Scientific Reports. 9: 17321. PMID 31754216 DOI: 10.1038/s41598-019-53643-y  0.609
2014 Hoekema S, Rinzema A, Tramper J, Wijffels RH, Janssen M. Deceleration-stats save much time during phototrophic culture optimization. Biotechnology and Bioengineering. 111: 792-802. PMID 24122652 DOI: 10.1002/bit.25131  0.497
2012 Schippers KJ, Sipkema D, Osinga R, Smidt H, Pomponi SA, Martens DE, Wijffels RH. Cultivation of sponges, sponge cells and symbionts: achievements and future prospects. Advances in Marine Biology. 62: 273-337. PMID 22664125 DOI: 10.1016/B978-0-12-394283-8.00006-0  0.743
2012 Leenen EJ, Boogert AA, van Lammeren AA, Tramper J, Wijffels RH. Dynamics of artificially immobilized Nitrosomonas europaea: Effect of biomass decay. Biotechnology and Bioengineering. 55: 630-41. PMID 18636573 DOI: 10.1002/(SICI)1097-0290(19970820)55:4<630::AID-BIT5>3.0.CO;2-I  0.518
2012 Wijffels RH, Hunik JH, Leenen EJ, Günther A, de Castro JM, Tramper J, Englund G, Bakketun A. Effects of diffusion limitation on immobilized nitrifying microorganisms at low temperatures. Biotechnology and Bioengineering. 45: 1-9. PMID 18623045 DOI: 10.1002/bit.260450102  0.419
2011 Schippers KJ, Martens DE, Pomponi SA, Wijffels RH. Cell cycle analysis of primary sponge cell cultures. In Vitro Cellular & Developmental Biology. Animal. 47: 302-11. PMID 21416188 DOI: 10.1007/S11626-011-9391-X  0.739
2010 Zijffers JW, Schippers KJ, Zheng K, Janssen M, Tramper J, Wijffels RH. Maximum photosynthetic yield of green microalgae in photobioreactors. Marine Biotechnology (New York, N.Y.). 12: 708-18. PMID 20177951 DOI: 10.1007/s10126-010-9258-2  0.737
2010 Wijffels RH, de Gooijer CD, Kortekaas S, Tramper J. Growth and substrate consumption of Nitrobacter agilis cells immobilized in carrageenan: part 2. Model evaluation. Biotechnology and Bioengineering. 38: 232-40. PMID 18600756 DOI: 10.1002/BIT.260380304  0.476
2010 de Gooijer CD, Wijffels RH, Tramper J. Growth and substrate consumption of Nitrobacter agilis cells immobilized in carrageenan: part 1. Dynamic modeling. Biotechnology and Bioengineering. 38: 224-31. PMID 18600755 DOI: 10.1002/BIT.260380303  0.464
2009 Koopmans M, Martens D, Wijffels RH. Towards Commercial Production of Sponge Medicines Marine Drugs. 7: 787-802. PMID 20098610 DOI: 10.3390/Md7040787  0.343
2009 Hoekema S, van Breukelen FR, Janssen M, Tramper J, Wijffels RH. Exploration of the hydrogen producing potential of Rhodobacter capsulatus chemostat cultures: The application of deceleration-stat and gradient-stat methodology. Biotechnology Progress. 25: 1343-52. PMID 19626702 DOI: 10.1002/btpr.196  0.495
2008 Koopmans M, Wijffels RH. Seasonal growth rate of the sponge Haliclona oculata (Demospongiae: Haplosclerida). Marine Biotechnology. 10: 502-510. PMID 18293037 DOI: 10.1007/S10126-008-9086-9  0.309
2008 Zijffers JW, Janssen M, Tramper J, Wijffels RH. Design process of an area-efficient photobioreactor. Marine Biotechnology (New York, N.Y.). 10: 404-15. PMID 18266033 DOI: 10.1007/s10126-007-9077-2  0.462
2008 Zijffers JF, Salim S, Janssen M, Tramper J, Wijffels RH. Capturing sunlight into a photobioreactor: Ray tracing simulations of the propagation of light from capture to distribution into the reactor Chemical Engineering Journal. 145: 316-327. DOI: 10.1016/J.CEJ.2008.08.011  0.411
2007 Caralt Sd, Uriz MJ, Wijffels RH. Cell culture from sponges: pluripotency and immortality Trends in Biotechnology. 25: 467-471. PMID 17825445 DOI: 10.1016/J.Tibtech.2007.08.006  0.379
2007 Bosma R, van Zessen E, Reith JH, Tramper J, Wijffels RH. Prediction of volumetric productivity of an outdoor photobioreactor. Biotechnology and Bioengineering. 97: 1108-20. PMID 17221886 DOI: 10.1002/bit.21319  0.482
2006 Hoekema S, Douma RD, Janssen M, Tramper J, Wijffels RH. Controlling light-use by Rhodobacter capsulatus continuous cultures in a flat-panel photobioreactor. Biotechnology and Bioengineering. 95: 613-26. PMID 16958141 DOI: 10.1002/BIT.21753  0.476
2006 Sipkema D, Yosef NAM, Adamczewski M, Osinga R, Mendola D, Tramper J, Wijffels RH. Hypothesized kinetic models for describing the growth of globular and encrusting demosponges Marine Biotechnology. 8: 40-51. PMID 16249967 DOI: 10.1007/S10126-005-5002-8  0.508
2005 Sipkema D, Franssen MCR, Osinga R, Tramper J, Wijffels RH. Marine sponges as pharmacy. Marine Biotechnology. 7: 142-162. PMID 15776313 DOI: 10.1007/S10126-004-0405-5  0.473
2005 Sipkema D, Osinga R, Schatton W, Mendola D, Tramper J, Wijffels RH. Large-scale production of pharmaceuticals by marine sponges: sea, cell, or synthesis? Biotechnology and Bioengineering. 90: 201-22. PMID 15739169 DOI: 10.1002/bit.20404  0.503
2003 Sipkema D, Heilig GHJ, Akkermans ADL, Osinga R, Tramper J, Wijffels RH. Sponge-cell culture? A molecular identification method for sponge cells. Marine Biotechnology. 5: 443-449. PMID 14730427 DOI: 10.1007/S10126-002-0090-1  0.549
2003 Hejazi MA, Andrysiewicz E, Tramper J, Wijffels RH. Effect of mixing rate on beta-carotene production and extraction by dunaliella salina in two-phase bioreactors. Biotechnology and Bioengineering. 84: 591-6. PMID 14574693 DOI: 10.1002/bit.10791  0.463
2003 Tramper J, Battershill C, Brandenburg W, Burgess G, Hill R, Luiten E, Müller W, Osinga R, Rorrer G, Tredici M, Uriz M, Wright P, Wijffels R. What to do in marine biotechnology? Biomolecular Engineering. 20: 467-471. PMID 12919833 DOI: 10.1016/S1389-0344(03)00077-7  0.395
2003 Barbosa MJ, Janssen M, Ham N, Tramper J, Wijffels RH. Microalgae cultivation in air-lift reactors: modeling biomass yield and growth rate as a function of mixing frequency. Biotechnology and Bioengineering. 82: 170-9. PMID 12584758 DOI: 10.1002/bit.10563  0.483
2003 Janssen M, Tramper J, Mur LR, Wijffels RH. Enclosed outdoor photobioreactors: light regime, photosynthetic efficiency, scale-up, and future prospects. Biotechnology and Bioengineering. 81: 193-210. PMID 12451556 DOI: 10.1002/bit.10468  0.47
2003 Osinga R, Belarbi el H, Grima EM, Tramper J, Wijffels RH. Progress towards a controlled culture of the marine sponge Pseudosuberites andrewsi in a bioreactor. Journal of Biotechnology. 100: 141-6. PMID 12423908 DOI: 10.1016/s0168-1656(02)00257-2  0.432
2003 Sipkema D, Wielink Rv, Lammeren AAMv, Tramper J, Osinga R, Wijffels RH. Primmorphs from seven marine sponges: formation and structure Journal of Biotechnology. 100: 127-139. PMID 12423907 DOI: 10.1016/S0168-1656(02)00253-5  0.512
2003 Bosma R, Van Spronsen WA, Tramper J, Wijffels RH. Ultrasound, a new separation technique to harvest microalgae Journal of Applied Phycology. 15: 143-153. DOI: 10.1023/A:1023807011027  0.388
2003 Michielsen MJF, Wijffels RH, Tramper J, Beeftink HH. Solid-to-Solid Bioconversions: Batch or Continuous? Cheminform. 34. DOI: 10.1002/CHIN.200327285  0.402
2002 Hejazi MA, de Lamarliere C, Rocha JM, Vermuë M, Tramper J, Wijffels RH. Selective extraction of carotenoids from the microalga Dunaliella salina with retention of viability. Biotechnology and Bioengineering. 79: 29-36. PMID 17590929 DOI: 10.1002/bit.10270  0.42
2002 Van Der Sluis C, Rahardjo YS, Smit BA, Kroon PJ, Hartmans S, Ter Schure EG, Tramper J, Wijffels R. Concomitant extracellular accumulation of alpha-keto acids and higher alcohols by Zygosaccharomyces rouxii. Journal of Bioscience and Bioengineering. 93: 117-24. PMID 16233175 DOI: 10.1016/s1389-1723(02)80002-0  0.366
2001 Osinga R, Kleijn R, Groenendijk E, Niesink P, Tramper J, Wijffels RH. Development of in vivo sponge cultures: particle feeding by the tropical sponge Pseudosuberites aff. andrewsi. Marine Biotechnology (New York, N.Y.). 3: 544-54. PMID 14961327 DOI: 10.1007/s1012601-0078-2  0.445
2001 van der Sluis C, Westerink BH, Dijkstal MM, Castelein SJ, van Boxtel AJ, Giuseppin ML, Tramper J, Wijffels RH. Estimation of steady-state culture characteristics during acceleration-stats with yeasts. Biotechnology and Bioengineering. 75: 267-75. PMID 11590599 DOI: 10.1002/bit.1181  0.451
2001 van der Sluis C, Stoffelen CJ, Castelein SJ, Engbers GH, ter Schure EG, Tramper J, Wijffels RH. Immobilized salt-tolerant yeasts: application of a new polyethylene-oxide support in a continuous stirred-tank reactor for flavour production. Journal of Biotechnology. 88: 129-39. PMID 11403847 DOI: 10.1016/s0168-1656(01)00264-4  0.446
2001 Barbosa MJ, Rocha JM, Tramper J, Wijffels RH. Acetate as a carbon source for hydrogen production by photosynthetic bacteria. Journal of Biotechnology. 85: 25-33. PMID 11164959 DOI: 10.1016/S0168-1656(00)00368-0  0.47
2001 van der Sluis C, Tramper J, Wijffels RH. Enhancing and accelerating flavour formation by salt-tolerant yeasts in Japanese soy-sauce processes Trends in Food Science & Technology. 12: 322-327. DOI: 10.1016/S0924-2244(01)00094-2  0.404
2001 Janssen M, Slenders P, Tramper J, Mur LR, Wijffels R. Photosynthetic efficiency of Dunaliella tertiolecta under short light/dark cycles Enzyme and Microbial Technology. 29: 298-305. DOI: 10.1016/S0141-0229(01)00387-8  0.44
2000 Michielsen MJ, Frielink C, Wijffels RH, Tramper J, Beeftink HH. Modeling solid-to-solid biocatalysis: integration of six consecutive steps. Biotechnology and Bioengineering. 69: 597-606. PMID 10918134 DOI: 10.1002/1097-0290(20000920)69:6<597::AID-BIT3>3.0.CO;2-C  0.407
2000 van der Sluis C, Mulder AN, Grolle KC, Engbers GH, ter Schure EG, Tramper J, Wijffels RH. Immobilized soy-sauce yeasts: development and characterization of a new polyethylene-oxide support. Journal of Biotechnology. 80: 179-88. PMID 10908798 DOI: 10.1016/S0168-1656(00)00263-7  0.436
2000 Michielsen MJ, Frielink C, Wijffels RH, Tramper J, Beeftink HH. Growth of Ca-D-malate crystals in a bioreactor. Biotechnology and Bioengineering. 69: 548-58. PMID 10898864 DOI: 10.1002/1097-0290(20000905)69:5<548::AID-BIT9>3.0.CO;2-0  0.414
2000 Michielsen MJ, Frielink C, Wijffels RH, Tramper J, Beeftink HH. D-malate production by permeabilized Pseudomonas pseudoalcaligenes; optimization of conversion and biocatalyst productivity. Journal of Biotechnology. 79: 13-26. PMID 10817338 DOI: 10.1016/S0168-1656(00)00220-0  0.449
2000 Janssen M, de Winter M, Tramper J, Mur LR, Snel J, Wijffels RH. Efficiency of light utilization of Chlamydomonas reinhardtii under medium-duration light/dark cycles. Journal of Biotechnology. 78: 123-37. PMID 10725536 DOI: 10.1016/S0168-1656(99)00233-3  0.457
2000 Janssen M, de Bresser L, Baijens T, Tramper J, Mur LR, Snel JF, Wijffels RH. Journal of Applied Phycology. 12: 225-237. DOI: 10.1023/A:1008151526680  0.423
1999 Osinga R, Tramper J, Wijffels RH. Cultivation of Marine Sponges Marine Biotechnology. 1: 509-532. PMID 10612677 DOI: 10.1007/Pl00011807  0.568
1999 Michielsen MJF, Frielink C, Meijer EA, van der Werf MJ, Wijffels RH, Tramper J, Beeftink HH. Stabilization of Maleate-Hydratase Activity of PermeabilizedPseudomonas Pseudoalcaligenes Biocatalysis and Biotransformation. 17: 125-137. DOI: 10.3109/10242429909015227  0.354
1999 Janssen M, Kuijpers TC, Veldhoen B, Ternbach MB, Tramper J, Mur LR, Wijffels RH. Specific growth rate of Chlamydomonas reinhardtii and Chlorella sorokiniana under medium duration light/dark cycles: 13–87 s Journal of Biotechnology. 70: 323-333. DOI: 10.1016/S0168-1656(99)00084-X  0.467
1999 Osinga R, De Beukelaer PB, Meijer EM, Tramper J, Wijffels RH. Growth of the sponge Pseudosuberites (aff.) andrewsi in a closed system Journal of Biotechnology. 70: 155-161. DOI: 10.1016/S0168-1656(99)00068-1  0.412
1998 Osinga R, Tramper J, Wijffels RH. Cultivation of marine sponges for metabolite production: Applications for biotechnology? Trends in Biotechnology. 16: 130-134. DOI: 10.1016/S0167-7799(97)01164-5  0.447
1998 Michielsen M, Meijer E, Wijffels R, Tramper J, Beeftink H. Kinetics of d-Malate Production by Permeabilized Pseudomonas Pseudoalcaligenes Enzyme and Microbial Technology. 22: 621-628. DOI: 10.1016/S0141-0229(97)00266-4  0.42
1998 Wijffels RH, Verheul M, Beverloo WA, Tramper J. Liquid/solid mass transfer in an air-lift loop reactor with a dispersed solid phase Journal of Chemical Technology & Biotechnology. 71: 147-154. DOI: 10.1002/(SICI)1097-4660(199802)71:2<147::AID-JCTB826>3.0.CO;2-X  0.38
1997 Martins Dos Santos VA, Leenen EJ, Rippoll MM, van der Sluis C, van Vliet T, Tramper J, Wijffels RH. Relevance of rheological properties of gel beads for their mechanical stability in bioreactors. Biotechnology and Bioengineering. 56: 517-29. PMID 18642272 DOI: 10.1002/(SICI)1097-0290(19971205)56:5<517::AID-BIT5>3.0.CO;2-L  0.379
1997 Leenen E, van Boxtel A, Englund G, Tramper J, Wijffels R. Reduced temperature sensitivity of immobilized Nitrobacter agilis cells caused by diffusion limitation Enzyme and Microbial Technology. 20: 573-580. DOI: 10.1016/S0141-0229(96)00214-1  0.425
1996 dos Santos V, Marchal L, Tramper J, Wijffels R. Modeling and Evaluation of an Integrated Nitrogen Removal System with Microorganisms Co-immobilized in Double-Layer Gel Beads Biotechnology Progress. 12: 240-248. DOI: 10.1021/bp9600041  0.399
1996 Wijffels RH, Buitelaar RM, Bucke C, Poulsen PB, Lilly MD, Cheetham PSJ, Tramper J. Guidelines for the characterization of immobilized cells Progress in Biotechnology. 11: 831-834. DOI: 10.1016/S0921-0423(96)80113-4  0.395
1996 Wijffels RH, de Gooijer CD, Schepers AW, Tramper J. Immobilized-cell growth: Diffusion limitation in expanding micro-colonies Progress in Biotechnology. 11: 249-256. DOI: 10.1016/S0921-0423(96)80034-7  0.462
1996 Leenen EJ, Dos Santos VA, Grolle KC, Tramper J, Wijffels R. Characteristics of and selection criteria for support materials for cell immobilization in wastewater treatment Water Research. 30: 2985-2996. DOI: 10.1016/S0043-1354(96)00209-6  0.425
1996 dos Santos VAPM, Bruijnse M, Tramper J, Wijffels RH. The magic-bead concept: an integrated approach to nitrogen removal with co-immobilized micro-organisms Applied Microbiology and Biotechnology. 45: 447-453. DOI: 10.1007/BF00578454  0.407
1995 Wijffels R, Eekhof MR, de Beer D, van den Heuvel JC, Tramper J. Pseudo-steady state oxygen-concentration profiles in an agar slab containing growing Nitrobacter agilis Journal of Fermentation and Bioengineering. 79: 167-170. DOI: 10.1016/0922-338X(95)94086-7  0.399
1995 Wijffels RH, de Gooijer CD, Schepers AW, Beuling EE, Mallée LF, Tramper J. Dynamic modeling of immobilized Nitrosomonas europaea: Implementation of diffusion limitation over expanding microcolonies Enzyme and Microbial Technology. 17: 462-471. DOI: 10.1016/0141-0229(94)00105-Z  0.449
1995 Wijffels R, Tramper J. Nitrification by immobilized cells Enzyme and Microbial Technology. 17: 482-492. DOI: 10.1016/0141-0229(94)00099-D  0.486
1994 Hunik JH, Tramper J, Wijffels RH. A strategy to scale up nitrification processes with immobilized cells of nitrosomonas europaea and nitrobacter agilis Bioprocess Engineering. 11: 73-82. DOI: 10.1007/BF00389563  0.449
1994 Wijffels RH, Schepers AW, Smit M, de Gooijer CD, Tramper J. Effect of initial biomass concentration on the growth of immobilized Nitrosomonas europaea Applied Microbiology and Biotechnology. 42: 153-157. DOI: 10.1007/BF00170239  0.469
1993 Santos VA, Tramper J, Wijffels RH. Simultaneous nitrification and denitrification using immobilized microorganisms. Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society For Artificial Cells and Immobilization Biotechnology. 21: 317-22. PMID 8399972 DOI: 10.3109/10731199309117369  0.441
1993 Wijffels RH, Leenen EJTM, Tramper J. Possibilities of Nitrification with Immobilized Cells in Waste-Water Treatment: Model or Practical System? Water Science and Technology. 27: 233-240. DOI: 10.2166/WST.1993.0503  0.48
1990 Wijffels R, Schukking G, Tramper J. Characterization of a denitrifying bacterium immobilized in ?-carrageenan Applied Microbiology and Biotechnology. 34. DOI: 10.1007/BF00170068  0.408
1989 Wijffels R, Tramper J. Performance of growing Nitrosomonas europaea cells immobilized in ?-carrageenan Applied Microbiology and Biotechnology. 32. DOI: 10.1007/BF00164831  0.477
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