Rachel E. Klevit, Ph.D. - Publications

Affiliations: 
Biochemistry University of Washington, Seattle, Seattle, WA 
Area:
Structural Biology; Biophysics: Biochemistry: RNA Biology: Cancer Biology
Website:
http://depts.washington.edu/biowww/pages/faculty-Klevit.shtml

153 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Cook MJ, Delbecq SP, Schweppe TP, Guttman M, Klevit RE, Brzovic PS. The ubiquitin ligase SspH1 from Salmonella uses a modular and dynamic E3 domain to catalyze substrate ubiquitylation. The Journal of Biological Chemistry. PMID 30459234 DOI: 10.1074/jbc.RA118.004247  0.48
2018 DaRosa PA, Harrison JS, Zelter A, Davis TN, Brzovic P, Kuhlman B, Klevit RE. A Bifunctional Role for the UHRF1 UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation. Molecular Cell. PMID 30392931 DOI: 10.1016/j.molcel.2018.09.029  0.32
2018 Akturk A, Wasilko DJ, Wu X, Liu Y, Zhang Y, Qiu J, Luo ZQ, Reiter KH, Brzovic PS, Klevit RE, Mao Y. Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector. Nature. PMID 29795346 DOI: 10.1038/s41586-018-0147-6  0.48
2018 DaRosa PA, Klevit RE, Xu W. Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs. Protein Science : a Publication of the Protein Society. PMID 29604130 DOI: 10.1002/pro.3413  0.32
2016 Stewart MD, Duncan ED, Coronado E, Brzovic PS, Klevit RE. Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms. Protein Science : a Publication of the Protein Society. PMID 27977889 DOI: 10.1002/pro.3091  0.48
2016 Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, et al. Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1. Elife. 5. PMID 27595565 DOI: 10.7554/eLife.17101  0.32
2016 DaRosa PA, Ovchinnikov S, Xu W, Klevit RE. Structural insights into SAM domain-mediated tankyrase oligomerization. Protein Science : a Publication of the Protein Society. PMID 27328430 DOI: 10.1002/pro.2968  0.32
2016 Stewart MD, Ritterhoff T, Klevit RE, Brzovic PS. E2 enzymes: more than just middle men. Cell Research. PMID 27002219 DOI: 10.1038/cr.2016.35  1
2015 Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE. Pharmacological chaperone for α-crystallin partially restores transparency in cataract models. Science (New York, N.Y.). 350: 674-7. PMID 26542570 DOI: 10.1126/science.aac9145  1
2015 Dove KK, Klevit RE, Rittinger K. pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit. The Embo Journal. PMID 26346274 DOI: 10.15252/embj.201592857  1
2015 Rajagopal P, Liu Y, Shi L, Clouser AF, Klevit RE. Structure of the α-crystallin domain from the redox-sensitive chaperone, HSPB1. Journal of Biomolecular Nmr. PMID 26243512 DOI: 10.1007/s10858-015-9973-0  1
2015 Vittal V, Stewart MD, Brzovic PS, Klevit RE. Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases. The Journal of Biological Chemistry. 290: 21244-51. PMID 26187467 DOI: 10.1074/jbc.R115.675165  1
2015 Hicks KG, Delbecq SP, Sancho-Vaello E, Blanc MP, Dove KK, Prost LR, Daley ME, Zeth K, Klevit RE, Miller SI. Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence. Elife. 4. PMID 26002083 DOI: 10.7554/eLife.06792  1
2015 Rajagopal P, Tse E, Borst AJ, Delbecq SP, Shi L, Southworth DR, Klevit RE. A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis. Elife. 4. PMID 25962097 DOI: 10.7554/eLife.07304  1
2015 Wu W, Nishikawa H, Fukuda T, Vittal V, Asano M, Miyoshi Y, Klevit RE, Ohta T. Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage. Cancer Research. 75: 1311-21. PMID 25634209 DOI: 10.1158/0008-5472.CAN-14-2796  1
2015 Vittal V, Shi L, Wenzel DM, Scaglione KM, Duncan ED, Basrur V, Elenitoba-Johnson KS, Baker D, Paulson HL, Brzovic PS, Klevit RE. Intrinsic disorder drives N-terminal ubiquitination by Ube2w. Nature Chemical Biology. 11: 83-9. PMID 25436519 DOI: 10.1038/nchembio.1700  1
2015 DaRosa PA, Wang Z, Jiang X, Pruneda JN, Cong F, Klevit RE, Xu W. Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. Nature. 517: 223-6. PMID 25327252 DOI: 10.1038/nature13826  0.4
2015 Delbecq SP, Rosenbaum JC, Klevit RE. A Mechanism of Subunit Recruitment in Human Small Heat Shock Protein Oligomers Biochemistry. 54: 4276-4284. DOI: 10.1021/acs.biochem.5b00490  1
2014 Morino H, Pierce SB, Matsuda Y, Walsh T, Ohsawa R, Newby M, Hiraki-Kamon K, Kuramochi M, Lee MK, Klevit RE, Martin A, Maruyama H, King MC, Kawakami H. Mutations in Twinkle primase-helicase cause Perrault syndrome with neurologic features. Neurology. 83: 2054-61. PMID 25355836 DOI: 10.1212/WNL.0000000000001036  1
2014 Warfield L, Tuttle LM, Pacheco D, Klevit RE, Hahn S. A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface. Proceedings of the National Academy of Sciences of the United States of America. 111: E3506-13. PMID 25122681 DOI: 10.1073/pnas.1412088111  1
2014 Nguyen L, Plafker KS, Starnes A, Cook M, Klevit RE, Plafker SM. The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin. Biochemistry. 53: 4004-14. PMID 24901938 DOI: 10.1021/bi500072v  1
2014 Navon Elkan P, Pierce SB, Segel R, Walsh T, Barash J, Padeh S, Zlotogorski A, Berkun Y, Press JJ, Mukamel M, Voth I, Hashkes PJ, Harel L, Hoffer V, Ling E, ... ... Klevit RE, et al. Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy. The New England Journal of Medicine. 370: 921-31. PMID 24552285 DOI: 10.1056/NEJMoa1307362  1
2014 Correia BE, Bates JT, Loomis RJ, Baneyx G, Carrico C, Jardine JG, Rupert P, Correnti C, Kalyuzhniy O, Vittal V, Connell MJ, Stevens E, Schroeter A, Chen M, Macpherson S, ... ... Klevit RE, et al. Proof of principle for epitope-focused vaccine design. Nature. 507: 201-6. PMID 24499818 DOI: 10.1038/nature12966  1
2014 Pruneda JN, Smith FD, Daurie A, Swaney DL, Villén J, Scott JD, Stadnyk AW, Le Trong I, Stenkamp RE, Klevit RE, Rohde JR, Brzovic PS. E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis. The Embo Journal. 33: 437-49. PMID 24446487 DOI: 10.1002/embj.201386386  1
2014 Metzger MB, Pruneda JN, Klevit RE, Weissman AM. RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochimica Et Biophysica Acta. 1843: 47-60. PMID 23747565 DOI: 10.1016/j.bbamcr.2013.05.026  0.4
2014 DaRosa PA, Wang Z, Jiang X, Pruneda JN, Cong F, Klevit RE, Xu W. Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal Nature. DOI: 10.1038/nature13826  1
2014 Metzger MB, Pruneda JN, Klevit RE, Weissman AM. RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination Biochimica Et Biophysica Acta - Molecular Cell Research. 1843: 47-60. DOI: 10.1016/j.bbamcr.2013.05.026  1
2013 Carlson AE, Rosenbaum JC, Brelidze TI, Klevit RE, Zagotta WN. Flavonoid regulation of HCN2 channels. The Journal of Biological Chemistry. 288: 33136-45. PMID 24085296 DOI: 10.1074/jbc.M113.501759  1
2013 Dove KK, Klevit RE. Structural biology: Parkin's serpentine shape revealed in the year of the snake Current Biology. 23: R691-R693. PMID 23968926 DOI: 10.1016/j.cub.2013.07.039  1
2013 Vittal V, Wenzel DM, Brzovic PS, Klevit RE. Biochemical and Structural Characterization of the Ubiquitin-Conjugating Enzyme UBE2W Reveals the Formation of a Noncovalent Homodimer Cell Biochemistry and Biophysics. 67: 103-110. PMID 23709311 DOI: 10.1007/s12013-013-9633-5  1
2013 Soss SE, Klevit RE, Chazin WJ. Activation of UbcH5c∼Ub is the result of a shift in interdomain motions of the conjugate bound to U-box E3 ligase E4B Biochemistry. 52: 2991-2999. PMID 23550736 DOI: 10.1021/bi3015949  1
2013 Pierce SB, Gersak K, Michaelson-Cohen R, Walsh T, Lee MK, Malach D, Klevit RE, King MC, Levy-Lahad E. Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome. American Journal of Human Genetics. 92: 614-20. PMID 23541342 DOI: 10.1016/j.ajhg.2013.03.007  1
2013 Starita LM, Pruneda JN, Lo RS, Fowler DM, Kim HJ, Hiatt JB, Shendure J, Brzovic PS, Fields S, Klevit RE. Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: E1263-72. PMID 23509263 DOI: 10.1073/pnas.1303309110  1
2013 Delbecq SP, Klevit RE. One size does not fit all: The oligomeric states of αb crystallin Febs Letters. 587: 1073-1080. PMID 23340341 DOI: 10.1016/j.febslet.2013.01.021  1
2012 Delbecq SP, Jehle S, Klevit R. Binding determinants of the small heat shock protein, αb-crystallin: Recognition of the ′IxI′ motif Embo Journal. 31: 4587-4594. PMID 23188086 DOI: 10.1038/emboj.2012.318  1
2012 Dove KK, Klevit RE. RING-between-RINGs-Keeping the safety on loaded guns Embo Journal. 31: 3792-3794. PMID 22960632 DOI: 10.1038/emboj.2012.260  1
2012 Pruneda JN, Littlefield PJ, Soss SE, Nordquist KA, Chazin WJ, Brzovic PS, Klevit RE. Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases Molecular Cell. 47: 933-942. PMID 22885007 DOI: 10.1016/j.molcel.2012.07.001  1
2012 Page RC, Pruneda JN, Amick J, Klevit RE, Misra S. Structural insights into the conformation and oligomerization of e2∼ubiquitin conjugates Biochemistry. 51: 4175-4187. PMID 22551455 DOI: 10.1021/bi300058m  1
2012 Wenzel DM, Klevit RE. Following Ariadne's thread: A new perspective on RBR ubiquitin ligases Bmc Biology. 10. PMID 22420831 DOI: 10.1186/1741-7007-10-24  1
2012 Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, et al. OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Molecular Cell. 45: 384-97. PMID 22325355 DOI: 10.1016/j.molcel.2012.01.011  1
2012 Juang YC, Landry MC, Sanches M, Vittal V, Leung C, Ceccarelli DF, Mateo ARF, Pruneda JN, Mao D, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, et al. OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function Molecular Cell. 46: 549. DOI: 10.1016/j.molcel.2012.05.013  1
2011 Brzovic PS, Heikaus CC, Kisselev L, Vernon R, Herbig E, Pacheco D, Warfield L, Littlefield P, Baker D, Klevit RE, Hahn S. The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex. Molecular Cell. 44: 942-53. PMID 22195967 DOI: 10.1016/j.molcel.2011.11.008  1
2011 Wenzel DM, Lissounov A, Brzovic PS, Klevit RE. UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids Nature. 474: 105-108. PMID 21532592 DOI: 10.1038/nature09966  1
2011 Pierce SB, Chisholm KM, Lynch ED, Lee MK, Walsh T, Opitz JM, Li W, Klevit RE, King MC. Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Proceedings of the National Academy of Sciences of the United States of America. 108: 6543-8. PMID 21464306 DOI: 10.1073/pnas.1103471108  1
2011 Jehle S, Vollmar BS, Bardiaux B, Dove KK, Rajagopal P, Gonen T, Oschkinat H, Klevit RE. N-terminal domain of alphaB-crystallin provides a conformational switch for multimerization and structural heterogeneity. Proceedings of the National Academy of Sciences of the United States of America. 108: 6409-14. PMID 21464278 DOI: 10.1073/pnas.1014656108  1
2011 Stoll KE, Brzovic PS, Davis TN, Klevit RE. The essential Ubc4/Ubc5 function in yeast is HECT E3-dependent, and RING E3-dependent pathways require only monoubiquitin transfer by Ubc4 Journal of Biological Chemistry. 286: 15165-15170. PMID 21357418 DOI: 10.1074/jbc.M110.203968  1
2011 Pruneda JN, Stoll KE, Bolton LJ, Brzovic PS, Klevit RE. Ubiquitin in motion: Structural studies of the ubiquitin-conjugating enzyme∼ubiquitin conjugate Biochemistry. 50: 1624-1633. PMID 21226485 DOI: 10.1021/bi101913m  1
2011 Wenzel DM, Stoll KE, Klevit RE. E2s: structurally economical and functionally replete. The Biochemical Journal. 433: 31-42. PMID 21158740 DOI: 10.1042/BJ20100985  1
2011 Wenzel DM, Stoll KE, Klevit RE. E2s: Structurally economical and functionally replete Biochemical Journal. 433: 535. DOI: 10.1042/BJ20100985  1
2010 Jehle S, Rajagopal P, Bardiaux B, Markovic S, Kühne R, Stout JR, Higman VA, Klevit RE, Van Rossum BJ, Oschkinat H. Solid-state NMR and SAXS studies provide a structural basis for the activation of αb-crystallin oligomers Nature Structural and Molecular Biology. 17: 1037-1042. PMID 20802487 DOI: 10.1038/nsmb.1891  1
2010 Pierce SB, Walsh T, Chisholm KM, Lee MK, Thornton AM, Fiumara A, Opitz JM, Levy-Lahad E, Klevit RE, King MC. Mutations in the DBP-deficiency protein HSD17B4 cause ovarian dysgenesis, hearing loss, and ataxia of Perrault Syndrome. American Journal of Human Genetics. 87: 282-8. PMID 20673864 DOI: 10.1016/j.ajhg.2010.07.007  1
2010 Le Trong I, Aprikian P, Kidd BA, Forero-Shelton M, Tchesnokova V, Rajagopal P, Rodriguez V, Interlandi G, Klevit R, Vogel V, Stenkamp RE, Sokurenko EV, Thomas WE. Structural basis for mechanical force regulation of the adhesin FimH via finger trap-like beta sheet twisting. Cell. 141: 645-55. PMID 20478255 DOI: 10.1016/j.cell.2010.03.038  1
2010 Levin I, Eakin C, Blanc MP, Klevit RE, Miller SI, Brzovic PS. Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase. Proceedings of the National Academy of Sciences of the United States of America. 107: 2848-53. PMID 20133640 DOI: 10.1073/pnas.0914821107  1
2010 Nordquist KA, Dimitrova YN, Brzovic PS, Ridenour WB, Munro KA, Soss SE, Caprioli RM, Klevit RE, Chazin WJ. Structural and functional characterization of the monomeric U-box domain from E4B. Biochemistry. 49: 347-55. PMID 20017557 DOI: 10.1021/bi901620v  1
2009 Heikaus CC, Pandit J, Klevit RE. Cyclic Nucleotide Binding GAF Domains from Phosphodiesterases: Structural and Mechanistic Insights Structure. 17: 1551-1557. PMID 20004158 DOI: 10.1016/j.str.2009.07.019  1
2009 Christensen DE, Klevit RE. Dynamic interactions of proteins in complex networks: Identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination Febs Journal. 276: 5381-5389. PMID 19712108 DOI: 10.1111/j.1742-4658.2009.07249.x  1
2009 Qian SB, Waldron L, Choudhary N, Klevit RE, Chazin WJ, Patterson C. Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer Journal of Biological Chemistry. 284: 26797-26802. PMID 19648119 DOI: 10.1074/jbc.M109.032334  1
2009 Jehle S, van Rossum B, Stout JR, Noguchi SM, Falber K, Rehbein K, Oschkinat H, Klevit RE, Rajagopal P. αB-Crystallin: A Hybrid Solid-State/Solution-State NMR Investigation Reveals Structural Aspects of the Heterogeneous Oligomer Journal of Molecular Biology. 385: 1481-1497. PMID 19041879 DOI: 10.1016/j.jmb.2008.10.097  1
2008 Martinez SE, Heikaus CC, Klevit RE, Beavo JA. The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change. The Journal of Biological Chemistry. 283: 25913-9. PMID 18614542 DOI: 10.1074/jbc.M802891200  1
2008 Heikaus CC, Stout JR, Sekharan MR, Eakin CM, Rajagopal P, Brzovic PS, Beavo JA, Klevit RE. Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change. The Journal of Biological Chemistry. 283: 22749-59. PMID 18534985 DOI: 10.1074/jbc.M801577200  1
2008 Prost LR, Daley ME, Bader MW, Klevit RE, Miller SI. The PhoQ histidine kinases of Salmonella and Pseudomonas spp. are structurally and functionally different: Evidence that pH and antimicrobial peptide sensing contribute to mammalian pathogenesis Molecular Microbiology. 69: 503-519. PMID 18532985 DOI: 10.1111/j.1365-2958.2008.06303.x  1
2008 Fox D, Le Trong I, Rajagopal P, Brzovic PS, Stenkamp RE, Klevit RE. Crystal structure of the BARD1 ankyrin repeat domain and its functional consequences Journal of Biological Chemistry. 283: 21179-21186. PMID 18480049 DOI: 10.1074/jbc.M802333200  1
2007 Christensen DE, Brzovic PS, Klevit RE. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages Nature Structural and Molecular Biology. 14: 941-948. PMID 17873885 DOI: 10.1038/nsmb1295  1
2007 Prost LR, Daley ME, Le Sage V, Bader MW, Le Moual H, Klevit RE, Miller SI. Activation of the Bacterial Sensor Kinase PhoQ by Acidic pH Molecular Cell. 26: 165-174. PMID 17466620 DOI: 10.1016/j.molcel.2007.03.008  1
2007 Eakin CM, Maccoss MJ, Finney GL, Klevit RE. Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase. Proceedings of the National Academy of Sciences of the United States of America. 104: 5794-9. PMID 17392432 DOI: 10.1073/pnas.0610887104  1
2006 Brzovic PS, Klevit RE. Ubiquitin transfer from the E2 perspective: Why is UbcH5 so promiscuous? Cell Cycle. 5: 2867-2873. PMID 17218787  1
2006 Brzovic PS, Lissounov A, Christensen DE, Hoyt DW, Klevit RE. A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination Molecular Cell. 21: 873-880. PMID 16543155 DOI: 10.1016/j.molcel.2006.02.008  1
2006 Cho US, Bader MW, Amaya MF, Daley ME, Klevit RE, Miller SI, Xu W. Metal bridges between the PhoQ sensor domain and the membrane regulate transmembrane signaling Journal of Molecular Biology. 356: 1193-1206. PMID 16406409 DOI: 10.1016/j.jmb.2005.12.032  1
2005 Sekharan MR, Rajagopal P, Klevit RE. Backbone 1H, 13C, and 15N resonance assignment of the 46 kDa dimeric GAF a domain of phosphodiesterase [5] Journal of Biomolecular Nmr. 33: 75. PMID 16222566 DOI: 10.1007/s10858-005-1615-5  1
2005 Brunet S, Scheuer T, Klevit R, Catterall WA. Modulation of CaV1.2 channels by Mg2+ acting at an EF-hand motif in the COOH-terminal domain. The Journal of General Physiology. 126: 311-23. PMID 16157690 DOI: 10.1085/jgp.200509333  1
2005 Bader MW, Sanowar S, Daley ME, Schneider AR, Cho U, Xu W, Klevit RE, Le Moual H, Miller SI. Recognition of antimicrobial peptides by a bacterial sensor kinase Cell. 122: 461-472. PMID 16096064 DOI: 10.1016/j.cell.2005.05.030  1
2005 Iverson HA, Fox D, Nadler LS, Klevit RE, Nathanson NM. Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal. The Journal of Biological Chemistry. 280: 24568-75. PMID 15870063 DOI: 10.1074/jbc.M501264200  1
2004 Nishikawa H, Ooka S, Sato K, Arima K, Okamoto J, Klevit RE, Fukuda M, Ohta T. Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase Journal of Biological Chemistry. 279: 3916-3924. PMID 14638690 DOI: 10.1074/jbc.M308540200  1
2003 Schaufler LE, Klevit RE. Mechanism of DNA binding by the ADR1 zinc finger transcription factor as determined by SPR Journal of Molecular Biology. 329: 931-939. PMID 12798683 DOI: 10.1016/S0022-2836(03)00550-3  1
2003 Brzovic PS, Keeffe JR, Nishikawa H, Miyamoto K, Fox D, Fukuda M, Ohta T, Klevit R. Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex. Proceedings of the National Academy of Sciences of the United States of America. 100: 5646-51. PMID 12732733 DOI: 10.1073/pnas.0836054100  1
2003 Yi Q, Rajagopal P, Klevit RE, Baker D. Structural and kinetic characterization of the simplified SH3 domain FP1 Protein Science. 12: 776-783. PMID 12649436 DOI: 10.1110/ps.0238603  1
2001 Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex Nature Structural Biology. 8: 833-837. PMID 11573085 DOI: 10.1038/nsb1001-833  1
2001 Brzovic PS, Meza JE, King MC, Klevit RE. BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions Journal of Biological Chemistry. 276: 41399-41406. PMID 11526114 DOI: 10.1074/jbc.M106551200  1
2000 Lee SY, Klevit RE. The whole is not the simple sum of its parts in calmodulin from S. cerevisiae Biochemistry. 39: 4225-4230. PMID 10757969 DOI: 10.1021/bi992697a  1
2000 Bowers PM, Klevit RE. Hydrogen bond geometry and 2H/1H fractionation in proteins Journal of the American Chemical Society. 122: 1030-1033. DOI: 10.1021/ja9927016  1
1999 Bowers PM, Schaufler LE, Klevit RE. A folding transition and novel zinc finger accessory domain in the transcription factor ADR1. Nature Structural Biology. 6: 478-85. PMID 10331877 DOI: 10.1038/8283  1
1999 Peterson RW, Nicholson EM, Thapar R, Klevit RE, Scholtz JM. Increased helix and protein stability through the introduction of a new tertiary hydrogen bond. Journal of Molecular Biology. 286: 1609-19. PMID 10064718 DOI: 10.1006/jmbi.1999.2574  1
1999 Meza JE, Brzovic PS, King MC, Klevit RE. Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1 Journal of Biological Chemistry. 274: 5659-5665. PMID 10026184 DOI: 10.1074/jbc.274.9.5659  1
1999 Rohl CA, Boeckman FA, Baker C, Scheuer T, Catterall WA, Klevit RE. Solution structure of the sodium channel inactivation gate. Biochemistry. 38: 855-61. PMID 9893979 DOI: 10.1021/bi9823380  1
1999 Rohl CA, Boeckman FA, Baker C, Scheuer T, Catterall WA, Klevit RE. Solution structure of the sodium channel inactivation gate Biochemistry. 38: X-861.  1
1998 Hughes RE, Brzovic PS, Dizhoor AM, Klevit RE, Hurley JB. Ca2+-dependent conformational changes in bovine GCAP-2 Protein Science. 7: 2675-2680. PMID 9865963  1
1998 Yi Q, Bystroff C, Rajagopal P, Klevit RE, Baker D. Prediction and structural characterization of an independently folding substructure in the src SH3 domain. Journal of Molecular Biology. 283: 293-300. PMID 9761691 DOI: 10.1006/jmbi.1998.2072  1
1998 Rajagopal P, Jones BE, Klevit RE. Solvent exchange rates of side-chain amide protons in proteins. Journal of Biomolecular Nmr. 11: 205-12. PMID 9679295  1
1998 Hyre DE, Klevit RE. A disorder-to-order transition coupled to DNA binding in the essential zinc-finger DNA-binding domain of yeast ADR1 Journal of Molecular Biology. 279: 929-943. PMID 9642072 DOI: 10.1006/jmbi.1998.1811  1
1998 Brzovic PS, Meza J, King MC, Klevit RE. The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain Journal of Biological Chemistry. 273: 7795-7799. PMID 9525870 DOI: 10.1074/jbc.273.14.7795  1
1997 Rajagopal P, Bruce Waygood E, Reizer J, Saier MH, Klevit RE. Demonstration of protein-protein interaction specificity by NMR chemical shift mapping Protein Science. 6: 2624-2627. PMID 9416611  1
1997 Schmiedeskamp M, Klevit RE. Paramagnetic cobalt as a probe of the orientation of an accessory dna- binding region of the yeast ADR1 zinc-finger protein Biochemistry. 36: 14003-14011. PMID 9369471 DOI: 10.1021/bi971364f  1
1997 Jones BE, Rajagopal P, Klevit RE. Phosphorylation on histidine is accompanied by localized structural changes in the phosphocarrier protein, HPr from Bacillus subtilis. Protein Science : a Publication of the Protein Society. 6: 2107-19. PMID 9336834 DOI: 10.1002/pro.5560061006  1
1997 Jones BE, Dossonnet V, Küster E, Hillen W, Deutscher J, Klevit RE. Binding of the catabolite repressor protein CcpA to its DNA target is regulated by phosphorylation of its corepressor HPr. The Journal of Biological Chemistry. 272: 26530-5. PMID 9334231 DOI: 10.1074/jbc.272.42.26530  1
1997 Schmiedeskamp M, Rajagopal P, Klevit RE. NMR chemical shift perturbation mapping of DNA binding by a zinc-finger domain from the yeast transcription factor ADR1 Protein Science. 6: 1835-1848. PMID 9300483  1
1997 Klevit RE, Jones B, Thaoar R, Pullen K, Raiagopal P. Effects of protein phosphorylation on protein structure, dynamics, and stability Faseb Journal. 11: A874.  1
1996 Thapar R, Nicholson EM, Rajagopal P, Waygood EB, Scholtz JM, Klevit RE. Influence of N-cap mutations on the structure and stability of Escherichia coli HPr. Biochemistry. 35: 11268-77. PMID 8784180 DOI: 10.1021/bi960349s  1
1996 Bowers PM, Klevit RE. Hydrogen bonding and equilibrium isotope enrichment in histidine-containing proteins. Nature Structural Biology. 3: 522-31. PMID 8646538  1
1995 Pullen K, Rajagopal P, Branchini BR, Huffine ME, Reizer J, Saier MH, Scholtz JM, Klevit RE. Phosphorylation of serine-46 in HPr, a key regulatory protein in bacteria, results in stabilization of its solution structure Protein Science. 4: 2478-2486. PMID 8580838  1
1995 Laue TM, Starovasnik MA, Weintraub H, Sun XH, Snider L, Klevit RE. MyoD forms micelles which can dissociate to form heterodimers with E47: implications of micellization on function. Proceedings of the National Academy of Sciences of the United States of America. 92: 11824-8. PMID 8524857 DOI: 10.1073/pnas.92.25.11824  1
1995 Hammen PK, Scholtz JM, Anderson JW, Waygood EB, Klevit RE. Investigation of a side-chain-side-chain hydrogen bond by mutagenesis, thermodynamics, and NMR spectroscopy Protein Science. 4: 936-944. PMID 7663349  1
1995 Moser MJ, Lee SY, Klevit RE, Davis TN. Ca2+ binding to calmodulin and its role in Schizosaccharomyces pombe as revealed by mutagenesis and NMR spectroscopy Journal of Biological Chemistry. 270: 20643-20652. PMID 7657644  1
1995 Peterkofsky A, Seok YJ, Amin N, Thapar R, Lee SY, Klevit RE, Waygood EB, Anderson JW, Gruschus J, Huq H. The Escherichia coli adenylyl cyclase complex: requirement of PTS proteins for stimulation by nucleotides. Biochemistry. 34: 8950-9. PMID 7619794  1
1995 Hughes RE, Brzovic PS, Klevit RE, Hurley JB. Calcium-dependent solvation of the myristoyl group of recoverin Biochemistry. 34: 11410-11416. PMID 7547868  1
1994 Klevit RE. Structure of a histidine-x4-histidine zinc finger domain: Insights into ADR1-UAS1 potein-DNA rcognition Biochemistry. 33: 4460-4470. PMID 8161501  1
1994 Bernstein BE, Hoffman RC, Klevit RE. Sequence-specific DNA recognition by Cys2, His2 zinc fingers Annals of the New York Academy of Sciences. 726: 92-104. PMID 8092710  1
1994 Rajagopal P, Bruce Waygood E, Klevit RE. Structural consequences of histidine phosphorylation: NMR characterization of the phosphohistidine form of histidine-containing protein from Bacillus subtilis and Escherichia coli Biochemistry. 33: 15271-15282. PMID 7803390  1
1994 Herzberg O, Klevit R. Unraveling a bacterial hexose transport pathway. Current Opinion in Structural Biology. 4: 814-22. PMID 7712285 DOI: 10.1016/0959-440X(94)90262-3  1
1994 Schmiedeskamp M, Klevit RE. Zinc finger diversity Current Opinion in Structural Biology. 4: 28-35. DOI: 10.1016/S0959-440X(94)90056-6  1
1993 Anderson JW, Pullen K, Georges F, Klevit RE, Waygood EB. The involvement of the arginine 17 residue in the active site of the histidine-containing protein, HPr, of the phosphoenolpyruvate:sugar phosphotransferase system of Escherichia coli. The Journal of Biological Chemistry. 268: 12325-33. PMID 8509371  1
1993 Sharma S, Hammen PK, Anderson JW, Leung A, Georges F, Hengstenberg W, Klevit RE, Waygood EB. Deamidation of HPr, a phosphocarrier protein of the phosphoenolpyruvate:sugar phosphotransferase system, involves asparagine 38 (HPr-1) and asparagine 12 (HPr-2) in isoaspartyl acid formation. The Journal of Biological Chemistry. 268: 17695-704. PMID 8349654  1
1993 Hoffman RC, Horvath SJ, Klevit RE. Structures of DNA-binding mutant zinc finger domains: Implications for DNA binding Protein Science. 2: 951-965. PMID 8318900  1
1993 Hoffman RC, Xu RX, Klevit RE, Herriott JR. A Simple Method for the Refinement of Models Derived from NMR Data Demonstrated on a Zinc-Finger Domain from Yeast ADR1 Journal of Magnetic Resonance, Series B. 102: 61-72. DOI: 10.1006/jmrb.1993.1062  1
1992 Starovasnik MA, Su DR, Beckingham K, Klevit RE. A series of point mutations reveal interactions between the calcium-binding sites of calmodulin. Protein Science : a Publication of the Protein Society. 1: 245-53. PMID 1363934 DOI: 10.1002/pro.5560010206  1
1992 Starovasnik MA, Blackwell TK, Laue TM, Weintraub H, Klevit RE. Folding topology of the disulfide-bonded dimeric DNA-binding domain of the myogenic determination factor MyoD. Biochemistry. 31: 9891-903. PMID 1327135  1
1992 Wittekind M, Rajagopal P, Branchini BR, Reizer J, Saier MH, Klevit RE. Solution structure of the phosphocarrier protein HPr from Bacillus subtilis by two-dimensional NMR spectroscopy Protein Science. 1: 1363-1376. PMID 1303754  1
1991 Klevit RE. ADR1a, a zinc finger peptide, exists in two folded conformations Biochemistry. 30: 3365-3371. PMID 2012802  1
1991 Klevit RE. Recognition of DNA by Cys2,His2 zinc fingers Science. 253: 1367+1393. PMID 1896847  1
1991 Parraga G, Klevit RE. Multidimensional nuclear magnetic resonance spectroscopy of DNA-binding proteins Methods in Enzymology. 208: 63-82. PMID 1779851  1
1991 Klevit RE. Reexamination of the secondary and tertiary structure of histidine-containing protein from escherichia coli by homonuclear and heteronuclear NMR spectroscopy Biochemistry. 30: 11842-11850. PMID 1751501  1
1991 Sharma S, Georges F, Delbaere LT, Lee JS, Klevit RE, Waygood EB. Epitope mapping by mutagenesis distinguishes between the two tertiary structures of the histidine-containing protein HPr. Proceedings of the National Academy of Sciences of the United States of America. 88: 4877-81. PMID 1711212  1
1990 Wittekind M, Reizer J, Klevit RE. Sequence-specific 1H NMR resonance assignments of Bacillus subtilis HPr: use of spectra obtained from mutants to resolve spectral overlap. Biochemistry. 29: 7191-200. PMID 2119803  1
1990 Klevit RE, Herriott JR, Horvath SJ. Solution structure of a zinc finger domain of yeast ADR1. Proteins. 7: 215-26. PMID 2114025 DOI: 10.1002/prot.340070303  1
1990 Párraga G, Horvath S, Hood L, Young ET, Klevit RE. Spectroscopic studies of wild-type and mutant "zinc finger" peptides: determinants of domain folding and structure. Proceedings of the National Academy of Sciences of the United States of America. 87: 137-41. PMID 2104978  1
1989 Krishna NR, Nettesheim DG, Klevit RE, Drobny G, Watt DD, Bugg CE. Proton nuclear magnetic resonance characterization of the aromatic residues in the variant-3 neurotoxin from Centruroides sculpturatus Ewing. Biochemistry. 28: 1555-62. PMID 2719918  1
1989 Nettesheim DG, Klevit RE, Drobny G, Watt DD, Krishna NR. Proton nuclear magnetic resonance studies on the variant-3 neurotoxin from Centruroides sculpturatus Ewing: sequential assignment of resonances. Biochemistry. 28: 1548-55. PMID 2719917  1
1989 Veigl ML, Klevit RE, Sedwick WD. The uses and limitations of calmodulin antagonists. Pharmacology & Therapeutics. 44: 181-239. PMID 2519344 DOI: 10.1016/0163-7258(89)90066-1  1
1989 Wittekind M, Reizer J, Deutscher J, Saier MH, Klevit RE. Common structural changes accompany the functional inactivation of HPr by seryl phosphorylation or by serine to aspartate substitution. Biochemistry. 28: 9908-12. PMID 2515891  1
1989 Parraga G, Young L, Klevit RE. Zinc-finger motifs and DNA binding. Trends in Biochemical Sciences. 14: 398. PMID 2510374 DOI: 10.1016/0968-0004(89)90283-1  1
1989 Waygood EB, Sharma S, Bhanot P, el-Kabbani OA, Delbaere LT, Georges F, Wittekind MG, Klevit RE. The structure of HPr and site-directed mutagenesis. Fems Microbiology Reviews. 5: 43-52. PMID 2483820  1
1989 Klevit RE. Women in chemical sciences [1] Chemical and Engineering News. 67: 2.  1
1988 Párraga G, Horvath SJ, Eisen A, Taylor WE, Hood L, Young ET, Klevit RE. Zinc-dependent structure of a single-finger domain of yeast ADR1. Science (New York, N.Y.). 241: 1489-92. PMID 3047872  1
1987 Klevit RE. Study of calmodulin-peptide interactions by NMR spectroscopy. Methods in Enzymology. 139: 197-206. PMID 3587023 DOI: 10.1016/0076-6879(87)39086-X  1
1987 Kintanar A, Klevit RE, Reid BR. Two-dimensional NMR investigation of a bent DNA fragment: assignment of the proton resonances and preliminary structure analysis. Nucleic Acids Research. 15: 5845-62. PMID 3039466 DOI: 10.1093/nar/15.14.5845  1
1987 Holler TP, Spaltenstein A, Turner E, Klevit RE, Shapiro BM, Hopkins PB. Synthesis and structure reassignment of mercaptohistidines of marine origin. Syntheses of L-ovothiols A and C Journal of Organic Chemistry. 52: 4420-4421.  1
1986 Klevit RE, Wemmer DE, Reid BR. 1H NMR studies on the interaction between distamycin A and a symmetrical DNA dodecamer. Biochemistry. 25: 3296-303. PMID 3730362  1
1986 Klevit RE, Waygood EB. Two-dimensional 1H NMR studies of histidine-containing protein from Escherichia coli. 3. Secondary and tertiary structure as determined by NMR. Biochemistry. 25: 7774-81. PMID 3542036  1
1986 Klevit RE, Drobny GP. Two-dimensional 1H NMR studies of histidine-containing protein from Escherichia coli. 2. Leucine resonance assignments by long-range coherence transfer. Biochemistry. 25: 7770-3. PMID 3542035  1
1986 Klevit RE, Drobny GP, Waygood EB. Two-dimensional 1H NMR studies of histidine-containing protein from Escherichia coli. 1. Sequential resonance assignments. Biochemistry. 25: 7760-9. PMID 3542034  1
1985 Klevit RE, Blumenthal DK, Wemmer DE, Krebs EG. Interaction of calmodulin and a calmodulin-binding peptide from myosin light chain kinase: major spectral changes in both occur as the result of complex formation. Biochemistry. 24: 8152-7. PMID 3841496  1
1985 Klevit RE. Improving two-dimensional NMR spectra by t1 ridge subtraction Journal of Magnetic Resonance (1969). 62: 551-555. DOI: 10.1016/0022-2364(85)90227-6  1
1984 Klevit RE, Dalgarno DC, Levine BA, Williams RJ. 1H-NMR studies of calmodulin. The nature of the Ca2+-dependent conformational change. European Journal of Biochemistry / Febs. 139: 109-14. PMID 6697998 DOI: 10.1111/j.1432-1033.1984.tb07983.x  1
1984 Dalgarno DC, Klevit RE, Levine BA, Williams RJ, Dobrowolski Z, Drabikowski W. 1H NMR studies of calmodulin. Resonance assignments by use of tryptic fragments. European Journal of Biochemistry / Febs. 138: 281-9. PMID 6697987 DOI: 10.1111/j.1432-1033.1984.tb07913.x  1
1984 Dalgarno DC, Klevit RE, Levine BA, Scott GM, Williams RJ, Gergely J, Grabarek Z, Leavis PC, Grand RJ, Drabikowski W. The nature of the trifluoperazine binding sites on calmodulin and troponin-C. Biochimica Et Biophysica Acta. 791: 164-72. PMID 6509062 DOI: 10.1016/0167-4838(84)90006-2  1
1984 Briggs MM, Klevit RE, Schachat FH. Heterogeneity of contractile proteins. Purification and characterization of two species of troponin T from rabbit fast skeletal muscle. The Journal of Biological Chemistry. 259: 10369-75. PMID 6469969  1
1984 Klevit RE, Vanaman TC. Azidotyrosylcalmodulin derivatives. Specific probes for protein-binding domains. The Journal of Biological Chemistry. 259: 15414-24. PMID 6096370  1
1984 Dalgarno D, Klevit RE, Levine BA, Williams RJP. The calcium receptor and trigger Trends in Pharmacological Sciences. 5: 266-271. DOI: 10.1016/0165-6147(84)90442-5  1
1983 Levine BA, Dalgarno DC, Esnouf MP, Klevit RE, Scott GM, Williams RJ. The mobility of calcium-trigger proteins and its function. Ciba Foundation Symposium. 93: 72-97. PMID 6551233 DOI: 10.1002/9780470720752.ch5  1
1983 Klevit RE. Spectroscopic analyses of calmodulin and its interactions. Methods in Enzymology. 102: 82-104. PMID 6316082  1
1982 Duncan JA, Bohle DS, Blanchard CA, Bossé ML, Noland TW, Ford CM, Powell MA, Sutton MC, Eggleston AC, Klevit RE, Krueger SM. Synthesis and thermal rearrangement of 7-(1,2-butadienyl)bicyclo[2.2.1]hept-2-ene [7-(3-methylallenyl)norbornene] Journal of the American Chemical Society. 104: 2837-2839.  1
1982 Klevit RE, Williams RJP. Specific effects of trifluoperazine binding to calmodulin and homologous proteins studied by PMR Federation Proceedings. 41: No. 1356.  1
1981 Klevit RE, Levine BA, Williams RJ. A study of calmodulin and its interaction with trifluoperazine by high resolution 1H NMR spectroscopy. Febs Letters. 123: 25-9. PMID 7202730 DOI: 10.1016/0014-5793(81)80011-7  1
1980 Esnouf MP, Klevit RE, Williams RJ. A comparison of different preparations if bovine brain calmodulin. Annals of the New York Academy of Sciences. 356: 380-1. PMID 6786158  1
Show low-probability matches.