Sarah Ellen O'Connor - Publications

2003-2011 Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
 2011- Biological Chemistry John Innes Center 
Biosynthesis and engineering of plant and plant-pathogen natural products

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Dang TT, Franke J, Carqueijeiro IST, Langley C, Courdavault V, O'Connor SE. Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes. Nature Chemical Biology. PMID 29942076 DOI: 10.1038/S41589-018-0078-4  0.48
2018 Caputi L, Franke J, Farrow SC, Chung K, Payne RME, Nguyen TD, Dang TT, Soares Teto Carqueijeiro I, Koudounas K, Dugé de Bernonville T, Ameyaw B, Jones DM, Vieira IJC, Courdavault V, O'Connor SE. Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science (New York, N.Y.). PMID 29724909 DOI: 10.1126/Science.Aat4100  0.36
2018 Stavrinides A, Tatsis E, Dang TT, Caputi L, Stevenson C, Lawson D, Schneider B, O'Connor S. Discovery of a short chain dehydrogenase from Catharanthus roseus that produces a novel monoterpene indole alkaloid. Chembiochem : a European Journal of Chemical Biology. PMID 29424954 DOI: 10.1002/Cbic.201700621  0.36
2017 Tatsis EC, Carqueijeiro I, Dugé de Bernonville T, Franke J, Dang TT, Oudin A, Lanoue A, Lafontaine F, Stavrinides AK, Clastre M, Courdavault V, O'Connor SE. A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate. Nature Communications. 8: 316. PMID 28827772 DOI: 10.1038/S41467-017-00154-X  0.44
2017 Dang TT, Franke J, Tatsis EC, O'Connor SE. Dual catalytic activity of a cytochrome P450 controls bifurcation at a metabolic branch point of alkaloid biosynthesis in Rauwolfia serpentina. Angewandte Chemie (International Ed. in English). PMID 28654178 DOI: 10.1002/Anie.201705010  0.64
2016 Stavrinides A, Tatsis EC, Caputi L, Foureau E, Stevenson CE, Lawson DM, Courdavault V, O'Connor SE. Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity. Nature Communications. 7: 12116. PMID 27418042 DOI: 10.1038/Ncomms12116  0.32
2016 Tatsis EC, O'Connor SE. New developments in engineering plant metabolic pathways. Current Opinion in Biotechnology. 42: 126-132. PMID 27132124 DOI: 10.1016/j.copbio.2016.04.012  0.96
2016 O'Connor S, Gornik HL, Froehlich JB, Gu X, Gray BH, Mace PD, Sharma A, Olin JW, Kim ES. Smoking and Adverse Outcomes in Fibromuscular Dysplasia: U.S. Registry Report. Journal of the American College of Cardiology. 67: 1750-1. PMID 27056782 DOI: 10.1016/j.jacc.2016.01.058  0.01
2016 Alagna F, Geu-Flores F, Kries H, Panara F, Baldoni L, O'Connor SE, Osbourn A. Identification and Characterization of the Iridoid Synthase Involved in Oleuropein Biosynthesis in Olive (Olea europaea) Fruits. The Journal of Biological Chemistry. 291: 5542-54. PMID 26709230 DOI: 10.1074/Jbc.M115.701276  0.04
2015 Kries H, Caputi L, Stevenson CE, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE. Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nature Chemical Biology. PMID 26551396 DOI: 10.1038/Nchembio.1955  0.8
2015 O'Connor SE. Engineering of Secondary Metabolism. Annual Review of Genetics. PMID 26393965 DOI: 10.1146/Annurev-Genet-120213-092053  0.8
2015 O'Connor SE. PLANT BIOCHEMISTRY. Fighting cancer while saving the mayapple. Science (New York, N.Y.). 349: 1167-8. PMID 26359390 DOI: 10.1126/Science.Aad1801  0.8
2015 Dugé de Bernonville T, Foureau E, Parage C, Lanoue A, Clastre M, Londono MA, Oudin A, Houillé B, Papon N, Besseau S, Glévarec G, Atehortùa L, Giglioli-Guivarc'h N, St-Pierre B, De Luca V, et al. Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome. Bmc Genomics. 16: 619. PMID 26285573 DOI: 10.1186/S12864-015-1678-Y  0.8
2015 Brown S, O'Connor SE. Halogenase Engineering for the Generation of New Natural Product Analogues. Chembiochem : a European Journal of Chemical Biology. 16: 2129-35. PMID 26256103 DOI: 10.1002/Cbic.201500338  0.8
2015 Van Moerkercke A, Steensma P, Schweizer F, Pollier J, Gariboldi I, Payne R, Vanden Bossche R, Miettinen K, Espoz J, Purnama PC, Kellner F, Seppänen-Laakso T, O'Connor SE, Rischer H, Memelink J, et al. The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus. Proceedings of the National Academy of Sciences of the United States of America. 112: 8130-5. PMID 26080427 DOI: 10.1073/Pnas.1504951112  0.8
2015 Kellner F, Geu-Flores F, Sherden NH, Brown S, Foureau E, Courdavault V, O'Connor SE. Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids. Chemical Communications (Cambridge, England). 51: 7626-8. PMID 25850027 DOI: 10.1039/C5Cc01309G  0.8
2015 Stavrinides A, Tatsis EC, Foureau E, Caputi L, Kellner F, Courdavault V, O'Connor SE. Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism. Chemistry & Biology. 22: 336-41. PMID 25772467 DOI: 10.1016/J.Chembiol.2015.02.006  0.8
2015 Kellner F, Kim J, Clavijo BJ, Hamilton JP, Childs KL, Vaillancourt B, Cepela J, Habermann M, Steuernagel B, Clissold L, McLay K, Buell CR, O'Connor SE. Genome-guided investigation of plant natural product biosynthesis. The Plant Journal : For Cell and Molecular Biology. 82: 680-92. PMID 25759247 DOI: 10.1111/Tpj.12827  0.8
2015 Jakubczyk D, Caputi L, Hatsch A, Nielsen CA, Diefenbacher M, Klein J, Molt A, Schröder H, Cheng JZ, Naesby M, O'Connor SE. Discovery and reconstitution of the cycloclavine biosynthetic pathway--enzymatic formation of a cyclopropyl group. Angewandte Chemie (International Ed. in English). 54: 5117-21. PMID 25712404 DOI: 10.1002/Anie.201410002  0.8
2015 Brown S, Clastre M, Courdavault V, O'Connor SE. De novo production of the plant-derived alkaloid strictosidine in yeast. Proceedings of the National Academy of Sciences of the United States of America. 112: 3205-10. PMID 25675512 DOI: 10.1073/Pnas.1423555112  0.8
2015 Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Müller-Uri F, Burlat V, O'Connor SE, Memelink J, Kreis W, Goossens A. Iridoid synthase activity is common among the plant progesterone 5β-reductase family. Molecular Plant. 8: 136-52. PMID 25578278 DOI: 10.1016/J.Molp.2014.11.005  0.8
2015 Van Moerkercke A, Steensma P, Schweizer F, Pollier J, Gariboldi I, Payne R, Vanden Bossche R, Miettinen K, Espoz J, Purnama PC, Kellner F, Seppänen-Laakso T, O'Connor SE, Rischer H, Memelink J, et al. The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus Proceedings of the National Academy of Sciences of the United States of America. 112: 8130-8135. DOI: 10.1073/pnas.1504951112  0.8
2015 Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Müller-Uri F, Burlat V, O'Connor SE, Memelink J, Kreis W, Goossens A. Iridoid synthase activity is common among the plant progesterone 5β-reductase family Molecular Plant. 8: 136-152. DOI: 10.1016/j.molp.2014.11.005  0.8
2015 Stavrinides A, Tatsis EC, Foureau E, Caputi L, Kellner F, Courdavault V, O'Connor SE. Unlocking the diversity of alkaloids in Catharanthus roseus: Nuclear localization suggests metabolic channeling in secondary metabolism Chemistry and Biology. 22: 336-341. DOI: 10.1016/j.chembiol.2015.02.006  0.8
2014 Lindner S, Geu-Flores F, Bräse S, Sherden NH, O'Connor SE. Conversion of substrate analogs suggests a Michael cyclization in iridoid biosynthesis. Chemistry & Biology. 21: 1452-6. PMID 25444551 DOI: 10.1016/J.Chembiol.2014.09.010  0.8
2014 Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Müller-Uri F, Burlat V, O'Connor SE, Memelink J, Kreis W, Goossens A. Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family. Molecular Plant. PMID 25239067 DOI: 10.1093/mp/ssu100  0.8
2014 Jakubczyk D, Cheng JZ, O'Connor SE. Biosynthesis of the ergot alkaloids Natural Product Reports. 31: 1328-1338. PMID 25164781 DOI: 10.1039/C4Np00062E  0.8
2014 Nielsen CA, Folly C, Hatsch A, Molt A, Schröder H, O'Connor SE, Naesby M. The important ergot alkaloid intermediate chanoclavine-I produced in the yeast Saccharomyces cerevisiae by the combined action of EasC and EasE from Aspergillus japonicus. Microbial Cell Factories. 13: 95. PMID 25112180 DOI: 10.1186/S12934-014-0095-2  0.8
2014 Valadao JM, Vigilante JA, DiGeorge NW, O'Connor SE, Bear A, Kenyon J, Annis H, Dituri J, Dituri AE, Whelan HT. Ketogenic diet for high partial pressure oxygen diving. Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. 41: 331-5. PMID 25109086  0.8
2014 O'Connor SE, Brutnell TP. Editorial overview: Growing the future: Synthetic biology in plants Current Opinion in Plant Biology. 19: iv-v. PMID 24866777 DOI: 10.1016/j.pbi.2014.05.005  0.8
2014 O'Connor SE, Richardson C, Trescher WH, Byler DL, Sather JD, Michael EH, Urbanik KB, Richards JL, Davis R, Zupanc ML, Zupec-Kania B. The ketogenic diet for the treatment of pediatric status epilepticus. Pediatric Neurology. 50: 101-3. PMID 24287234 DOI: 10.1016/j.pediatrneurol.2013.07.020  0.8
2014 Nielsen CAF, Folly C, Hatsch A, Molt A, Schröder H, O'Connor SE, Naesby M. The important ergot alkaloid intermediate chanoclavine-I produced in the yeast saccharomyces cerevisiae by the combined action of EasC and EasE from aspergillus japonicus Microbial Cell Factories. 13. DOI: 10.1186/s12934-014-0095-2  0.8
2013 Besseau S, Kellner F, Lanoue A, Thamm AMK, Salim V, Schneider B, Geu-Flores F, Höfer R, Guirimand G, Guihur A, Oudin A, Glevarec G, Foureau E, Papon N, Clastre M, et al. A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus Plant Physiology. 163: 1792-1803. PMID 24108213 DOI: 10.1104/Pp.113.222828  0.8
2013 Runguphan W, O'Connor SE. Diversification of monoterpene indole alkaloid analogs through cross-coupling Organic Letters. 15: 2850-2853. PMID 23713451 DOI: 10.1021/ol401179k  0.8
2013 O'Connor SE, Gibbons S. Editorial: Modern Methods in Plant Natural Products themed issue Natural Product Reports. 30: 483-484. PMID 23462908 DOI: 10.1039/C3Np90008H  0.8
2013 Glenn WS, Runguphan W, O'Connor SE. Recent progress in the metabolic engineering of alkaloids in plant systems Current Opinion in Biotechnology. 24: 354-365. PMID 22954587 DOI: 10.1016/j.copbio.2012.08.003  0.8
2012 Geu-Flores F, Sherden NH, Courdavault V, Burlat V, Glenn WS, Wu C, Nims E, Cui Y, O'Connor SE. An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis. Nature. 492: 138-42. PMID 23172143 DOI: 10.1038/Nature11692  0.8
2012 O'Connor SE. Strategies for engineering plant natural products: The iridoid-derived monoterpene indole alkaloids of catharanthus roseus Methods in Enzymology. 515: 189-206. PMID 22999175 DOI: 10.1016/B978-0-12-394290-6.00009-4  0.8
2012 Ruff BM, Bräse S, O'Connor SE. Biocatalytic production of tetrahydroisoquinolines. Tetrahedron Letters. 53: 1071-1074. PMID 22966211 DOI: 10.1016/J.Tetlet.2011.12.089  0.8
2012 DellaPenna D, O'Connor SE. Plant science: Plant gene clusters and opiates Science. 336: 1648-1649. PMID 22745410 DOI: 10.1126/Science.1225473  0.8
2012 Runguphan W, Glenn WS, O'Connor SE. Redesign of a dioxygenase in morphine biosynthesis Chemistry and Biology. 19: 674-678. PMID 22726681 DOI: 10.1016/J.Chembiol.2012.04.017  0.8
2012 O'Connor SE. Alkaloids Natural Products in Chemical Biology. 209-237. DOI: 10.1002/9781118391815.ch9  0.8
2011 Glenn WS, Nims E, O'Connor SE. Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor Journal of the American Chemical Society. 133: 19346-19349. PMID 22050348 DOI: 10.1021/Ja2089348  0.8
2011 Hicks MA, Barber AE, Giddings LA, Caldwell J, O'Connor SE, Babbitt PC. The evolution of function in strictosidine synthase-like proteins Proteins: Structure, Function and Bioinformatics. 79: 3082-3098. PMID 21948213 DOI: 10.1002/Prot.23135  0.8
2011 Liscombe DK, O'Connor SE. A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus Phytochemistry. 72: 1969-1977. PMID 21802100 DOI: 10.1016/j.phytochem.2011.07.001  0.8
2011 Yogi A, Callera GE, O'Connor SE, He Y, Correa JW, Tostes RC, Mazur A, Touyz RM. Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia. Journal of Hypertension. 29: 1400-10. PMID 21602712 DOI: 10.1097/Hjh.0B013E32834786D6  0.8
2011 Giddings LA, Liscombe DK, Hamilton JP, Childs KL, DellaPenna D, Buell CR, O'Connor SE. A stereoselective hydroxylation step of alkaloid biosynthesis by a unique cytochrome P450 in Catharanthus roseus Journal of Biological Chemistry. 286: 16751-16757. PMID 21454651 DOI: 10.1074/Jbc.M111.225383  0.8
2011 Goetz KE, Coyle CM, Cheng JZ, O'Connor SE, Panaccione DG. Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus Current Genetics. 57: 201-211. PMID 21409592 DOI: 10.1007/S00294-011-0336-4  0.8
2010 Runguphan W, Qu X, O'Connor SE. Integrating carbon-halogen bond formation into medicinal plant metabolism Nature. 468: 461-467. PMID 21048708 DOI: 10.1038/nature09524  0.8
2010 Liscombe DK, Usera AR, O'Connor SE. Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 107: 18793-18798. PMID 20956330 DOI: 10.1073/pnas.1009003107  0.8
2010 Cheng JZ, Coyle CM, Panaccione DG, O'Connor SE. Controlling a structural branch point in ergot alkaloid biosynthesis Journal of the American Chemical Society. 132: 12835-12837. PMID 20735127 DOI: 10.1021/Ja105785P  0.8
2010 Bernhardt P, Usera AR, O'Connor SE. Biocatalytic asymmetric formation of tetrahydro-β-carbolines. Tetrahedron Letters. 51: 4400-4402. PMID 20689670 DOI: 10.1016/j.tetlet.2010.06.075  0.8
2010 Zupanc ML, Roell Werner R, Schwabe MS, O'Connor SE, Marcuccilli CJ, Hecox KE, Chico MS, Eggener KA. Efficacy of felbamate in the treatment of intractable pediatric epilepsy. Pediatric Neurology. 42: 396-403. PMID 20472190 DOI: 10.1016/j.pediatrneurol.2010.02.013  0.8
2010 Coyle CM, Cheng JZ, O'Connor SE, Panaccione DG. An old yellow enzyme gene controls the branch point between aspergillus fumigatus and claviceps purpurea ergot alkaloid pathways Applied and Environmental Microbiology. 76: 3898-3903. PMID 20435769 DOI: 10.1128/Aem.02914-09  0.8
2010 Cheng JZ, Coyle CM, Panaccione DG, O'Connor SE. A role for old yellow enzyme in ergot alkaloid biosynthesis Journal of the American Chemical Society. 132: 1776-1777. PMID 20102147 DOI: 10.1021/Ja910193P  0.8
2010 Yogi A, O'Connor SE, Callera GE, Tostes RC, Touyz RM. Receptor and nonreceptor tyrosine kinases in vascular biology of hypertension Current Opinion in Nephrology and Hypertension. 19: 169-176. PMID 20051848 DOI: 10.1097/Mnh.0B013E3283361C24  0.8
2010 Zupanc ML, Rubio EJ, Werner RR, Schwabe MJ, Mueller WM, Lew SM, Marcuccilli CJ, O'Connor SE, Chico MS, Eggener KA, Hecox KE. Epilepsy surgery outcomes: quality of life and seizure control. Pediatric Neurology. 42: 12-20. PMID 20004857 DOI: 10.1016/j.pediatrneurol.2009.07.018  0.8
2010 Bernhardt P, Usera AR, O'Connor SE. Biocatalytic asymmetric formation of tetrahydro-β-carbolines Tetrahedron Letters. 51: 4400-4402. DOI: 10.1016/j.tetlet.2010.06.075  0.8
2009 O'Connor SE, Zupanc ML. Women and epilepsy. The Journal of Pediatric Pharmacology and Therapeutics : Jppt : the Official Journal of Ppag. 14: 212-20. PMID 23055906 DOI: 10.5863/1551-6776-14.4.212  0.8
2009 Bernhardt P, O'Connor SE. Synthesis and biochemical evaluation of des-vinyl secologanin aglycones with alternate stereochemistry. Tetrahedron Letters. 50: 7118-7120. PMID 20161519 DOI: 10.1016/j.tetlet.2009.09.171  0.8
2009 Lee HY, Yerkes N, O'Connor SE. Aza-Tryptamine Substrates in Monoterpene Indole Alkaloid Biosynthesis Chemistry and Biology. 16: 1225-1229. PMID 20064432 DOI: 10.1016/J.Chembiol.2009.11.016  0.8
2009 Friedrich A, Bräse S, O'Connor SE. Synthesis of 4-, 5-, 6-, and 7-Azidotryptamines. Tetrahedron Letters. 50: 75-76. PMID 20062517 DOI: 10.1016/J.Tetlet.2008.10.091  0.8
2009 Bernhardt P, Yerkes N, O'Connor SE. Bypassing stereoselectivity in the early steps of alkaloid biosynthesis Organic and Biomolecular Chemistry. 7: 4166-4168. PMID 19795053 DOI: 10.1039/B916027M  0.8
2009 Runguphan W, Maresh JJ, O'Connor SE. Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture Proceedings of the National Academy of Sciences of the United States of America. 106: 13673-13678. PMID 19666570 DOI: 10.1073/Pnas.0903393106  0.8
2009 Usera AR, O'Connor SE. Mechanistic advances in plant natural product enzymes. Current Opinion in Chemical Biology. 13: 492-8. PMID 19632140 DOI: 10.1016/j.cbpa.2009.06.019  0.8
2009 Löhn M, Plettenburg O, Ivashchenko Y, Kannt A, Hofmeister A, Kadereit D, Schaefer M, Linz W, Kohlmann M, Herbert JM, Janiak P, O'Connor SE, Ruetten H. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 54: 676-83. PMID 19597037 DOI: 10.1161/HYPERTENSIONAHA.109.134353  0.8
2009 Bernhardt P, O'Connor SE. Opportunities for enzyme engineering in natural product biosynthesis Current Opinion in Chemical Biology. 13: 35-42. PMID 19201253 DOI: 10.1016/j.cbpa.2009.01.005  0.8
2009 Kuban KC, Allred EN, O'Shea TM, Paneth N, Pagano M, Dammann O, Leviton A, Du Plessis A, Westra SJ, Miller CR, Bassan H, Krishnamoorthy K, Junewick J, Olomu N, Romano E, et al. Cranial ultrasound lesions in the NICU predict cerebral palsy at age 2 years in children born at extremely low gestational age. Journal of Child Neurology. 24: 63-72. PMID 19168819 DOI: 10.1177/0883073808321048  0.8
2009 Runguphan W, O'Connor SE. Metabolic reprogramming of periwinkle plant culture Nature Chemical Biology. 5: 151-153. PMID 19151732 DOI: 10.1038/Nchembio.141  0.8
2009 Bernhardt P, O'Connor SE. Synthesis and biochemical evaluation of des-vinyl secologanin aglycones with alternate stereochemistry Tetrahedron Letters. 50: 7118-7120. DOI: 10.1016/j.tetlet.2009.09.171  0.8
2009 Usera AR, O'Connor SE. Mechanistic advances in plant natural product enzymes Current Opinion in Chemical Biology. 13: 485-491. DOI: 10.1016/j.cbpa.2009.06.019  0.8
2008 McCoy E, O'Connor SE. Natural products from plant cell cultures Progress in Drug Research. 65: 330-370. PMID 18084920 DOI: 10.1007/978-3-7643-8117-2_9  0.8
2008 Maresh JJ, Giddings LA, Friedrich A, Loris EA, Panjikar S, Trout BL, Stöckigt J, Peters B, O'Connor SE. Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme. Journal of the American Chemical Society. 130: 710-23. PMID 18081287 DOI: 10.1021/Ja077190Z  0.8
2008 Yerkes N, Wu JX, McCoy E, Galan MC, Chen S, O'Connor SE. Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis Bioorganic and Medicinal Chemistry Letters. 18: 3095-3098. PMID 18061449 DOI: 10.1016/J.Bmcl.2007.11.063  0.8
2007 Bernhardt P, McCoy E, O'Connor SE. Rapid Identification of Enzyme Variants for Reengineered Alkaloid Biosynthesis in Periwinkle Chemistry and Biology. 14: 888-897. PMID 17719488 DOI: 10.1016/J.Chembiol.2007.07.008  0.8
2007 Galan MC, McCoy E, O'Connor SE. Chemoselective derivatization of alkaloids in periwinkle Chemical Communications. 3249-3251. PMID 17668090 DOI: 10.1039/B708919H  0.8
2006 Chen S, Galan MC, Coltharp C, O'Connor SE. Redesign of a Central Enzyme in Alkaloid Biosynthesis Chemistry and Biology. 13: 1137-1141. PMID 17113995 DOI: 10.1016/J.Chembiol.2006.10.009  0.8
2006 McCoy E, O'Connor SE. Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus Journal of the American Chemical Society. 128: 14276-14277. PMID 17076499 DOI: 10.1021/Ja066787W  0.8
2006 O'Connor SE. Cyclization of natural products Nature Chemical Biology. 2: 511-512. PMID 16983382 DOI: 10.1038/Nchembio1006-511  0.8
2006 O'Connor SE, Maresh JJ. Chemistry and biology of monoterpene indole alkaloid biosynthesis Natural Product Reports. 23: 532-547. PMID 16874388 DOI: 10.1039/B512615K  0.8
2006 Janiak P, Bidouard JP, Cadrouvele C, Poirier B, Gouraud L, Grataloup Y, Pierre F, Bruneval P, O'Connor SE, Herbert JM. Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats. European Journal of Pharmacology. 534: 271-9. PMID 16516882 DOI: 10.1016/j.ejphar.2006.01.032  0.8
2006 McCoy E, Galan MC, O'Connor SE. Substrate specificity of strictosidine synthase Bioorganic and Medicinal Chemistry Letters. 16: 2475-2478. PMID 16481164 DOI: 10.1016/J.Bmcl.2006.01.098  0.8
2006 O'Connor SE, McCoy E. Chapter one Terpene indole alkaloid biosynthesis Recent Advances in Phytochemistry. 40: 1-22. DOI: 10.1016/S0079-9920(06)80035-3  0.8
2006 Galan MC, O'Connor SE. Semi-synthesis of secologanin analogues Tetrahedron Letters. 47: 1563-1565. DOI: 10.1016/J.Tetlet.2006.01.009  0.88
2005 Kuban KC, O'Shea M, Allred E, Leviton A, Gilmore H, DuPlessis A, Krishnamoorthy K, Hahn C, Soul J, O'Connor SE, Miller K, Church PT, Keller C, Bream R, Adair R, et al. Video and CD-ROM as a training tool for performing neurologic examinations of 1-year-old children in a multicenter epidemiologic study. Journal of Child Neurology. 20: 829-31. PMID 16417880 DOI: 10.1177/08830738050200101001  0.8
2005 Vaillancourt FH, Yeh E, Vosburg DA, O'Connor SE, Walsh CT. Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis. Nature. 436: 1191-4. PMID 16121186 DOI: 10.1038/Nature03797  0.72
2005 Poirier B, Bidouard JP, Cadrouvele C, Marniquet X, Staels B, O'Connor SE, Janiak P, Herbert JM. The anti-obesity effect of rimonabant is associated with an improved serum lipid profile. Diabetes, Obesity & Metabolism. 7: 65-72. PMID 15642077 DOI: 10.1111/j.1463-1326.2004.00374.x  0.8
2004 Guilbert F, Lainée P, Dubreuil B, McCort G, O'Connor SE, Janiak P, Herbert JM. Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists. European Journal of Pharmacology. 497: 55-63. PMID 15321735 DOI: 10.1016/j.ejphar.2004.06.024  0.8
2004 Berthonneche C, Sulpice T, Boucher F, Gouraud L, de Leiris J, O'Connor SE, Herbert JM, Janiak P. New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in rats. American Journal of Physiology. Heart and Circulatory Physiology. 287: H340-50. PMID 15210453 DOI: 10.1152/ajpheart.01210.2003  0.8
2004 Hicks LM, O'Connor SE, Mazur MT, Walsh CT, Kelleher NL. Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. Chemistry & Biology. 11: 327-35. PMID 15123262 DOI: 10.1016/J.Chembiol.2004.02.021  0.8
2004 Visconte C, Sainte-Marie M, Lorrain J, Millet L, O'Connor SE, Schaeffer P, Herbert JM. SSR182289A enhances thrombolysis induced by fibrinolytic agents in rabbit models of venous and arterial thrombosis Journal of Thrombosis and Haemostasis. 2: 629-636. PMID 15102019 DOI: 10.1111/j.1538-7836.2004.00687.x  0.8
2004 Altenburger JM, Lassalle GY, Matrougui M, Galtier D, Jetha JC, Bocskei Z, Berry CN, Lunven C, Lorrain J, Herault JP, Schaeffer P, O'Connor SE, Herbert JM. SSR182289A, a selective and potent orally active thrombin inhibitor. Bioorganic & Medicinal Chemistry. 12: 1713-30. PMID 15028263 DOI: 10.1016/J.Bmc.2004.01.016  0.8
2004 Lorrain J, Lechaire I, Gauffeny C, Masson R, Roome N, Herault JP, O'Connor SE, Schaeffer P, Herbert JM. Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel. The Journal of Pharmacology and Experimental Therapeutics. 309: 235-40. PMID 14718579 DOI: 10.1124/Jpet.103.059873  0.8
2004 Couch R, O'Connor SE, Seidle H, Walsh CT, Parry R. Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine. Journal of Bacteriology. 186: 35-42. PMID 14679222 DOI: 10.1128/Jb.186.1.35-42.2004  0.8
2003 Molinari BL, Tasat DR, Palmieri MA, O'Connor SE, Cabrini RL. Cell-Based Quantitative Evaluation of the MTT Assay Analytical and Quantitative Cytology and Histology. 25: 254-262. PMID 14603722  0.8
2003 O'Connor SE, Walsh CT, Liu F. Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces. Angewandte Chemie (International Ed. in English). 42: 3917-21. PMID 12949868 DOI: 10.1002/Anie.200352077  0.8
2003 Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Le Fur G, O'Connor SE, Herbert JM. Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion Journal of Pharmacology and Experimental Therapeutics. 306: 828-837. PMID 12928523 DOI: 10.1124/jpet.103.052068  0.8
2003 O'Connor SE, Kwiatkowski DJ, Roberts PS, Wollmann RL, Huttenlocher PR. A family with seizures and minor features of tuberous sclerosis and a novel TSC2 mutation. Neurology. 61: 409-12. PMID 12913212 DOI: 10.1212/01.Wnl.0000073272.47681.Bb  0.8
2003 Barbe F, Gautier E, Bidouard JP, Grosset A, O'Connor SE, Janiak P. SL65.0472 blocks 5-hydroxytryptamine-induced vasoconstriction in a dog hindlimb ischemia model. European Journal of Pharmacology. 474: 117-20. PMID 12909202  0.8
2003 Walsh CT, O'Connor SE, Schneider TL. Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits. Journal of Industrial Microbiology & Biotechnology. 30: 448-55. PMID 12707798 DOI: 10.1007/S10295-003-0044-2  0.8
2003 Bidouard JP, Duval N, Kapui Z, Herbert JM, O'Connor SE, Janiak P. SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury. European Journal of Pharmacology. 461: 49-52. PMID 12568915  0.8
2003 Lorrain J, Millet L, Lechaire I, Lochot S, Ferrari P, Visconte C, Sainte-Marie M, Lunven C, Berry CN, Schaeffer P, Herbert JM, O'Connor SE. Antithrombotic properties of SSR182289A, a new, orally active thrombin inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 304: 567-74. PMID 12538808 DOI: 10.1124/Jpet.102.044610  0.8
2002 Berry CN, Lassalle G, Lunven C, Altenburger JM, Guilbert F, Lalé A, Hérault JP, Lecoffre C, Pfersdorff C, Herbert JM, O'Connor SE. SSR182289A, a novel, orally active thrombin inhibitor: in vitro profile and ex vivo anticoagulant activity. The Journal of Pharmacology and Experimental Therapeutics. 303: 1189-98. PMID 12438543 DOI: 10.1124/jpet.102.040667  0.8
2002 Janiak P, Lainée P, Grataloup Y, Luyt CE, Bidouard JP, Michel JB, O'Connor SE, Herbert JM. Serotonin receptor blockade improves distal perfusion after lower limb ischemia in the fatty Zucker rat. Cardiovascular Research. 56: 293-302. PMID 12393100 DOI: 10.1016/S0008-6363(02)00538-2  0.8
2002 Schneider TL, Walsh CT, O'Connor SE. Utilization of alternate substrates by the first three modules of the epothilone synthetase assembly line. Journal of the American Chemical Society. 124: 11272-3. PMID 12236733 DOI: 10.1021/Ja0274498  0.8
2002 O'Connor SE, Chen H, Walsh CT. Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces. Biochemistry. 41: 5685-94. PMID 11969430 DOI: 10.1021/Bi020006W  0.8
2002 Chen H, Hubbard BK, O'Connor SE, Walsh CT. Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics. Chemistry & Biology. 9: 103-12. PMID 11841943 DOI: 10.1016/S1074-5521(02)00090-X  0.8
2001 Chen H, Thomas MG, O'Connor SE, Hubbard BK, Burkart MD, Walsh CT. Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics. Biochemistry. 40: 11651-9. PMID 11570865 DOI: 10.1021/Bi0115434  0.8
2001 O'Connor SE, Pearce J, Smith RL, Voegeli D, Walton P. An evaluation of the clinical performance of newly qualified nurses: a competency based assessment. Nurse Education Today. 21: 559-68. PMID 11559010 DOI: 10.1054/nedt.2001.0594  0.8
2001 O'Connor SE, Pohlmann J, Imperiali B, Saskiawan I, Yamamoto K. Probing the effect of the outer saccharide residues of N-linked glycans on peptide conformation. Journal of the American Chemical Society. 123: 6187-8. PMID 11414857 DOI: 10.1021/Ja010094S  0.8
2001 Berry CN, Lorrain J, Lochot S, Delahaye M, Lalé A, Savi P, Lechaire I, Ferrari P, Bernat A, Schaeffer P, Janiak P, Duval N, Grosset A, Herbert JM, O'Connor SE. Antiplatelet and antithrombotic activity of SL65.0472, a mixed 5-HT1B/5-HT2A receptor antagonist. Thrombosis and Haemostasis. 85: 521-8. PMID 11307825  0.8
2001 O'Connor SE, Grosset A, La Rochelle CD, Gautier E, Bidouard JP, Robineau P, Caille D, Janiak P. Cardiovascular effects of SL65.0472, a 5-HT receptor antagonist. European Journal of Pharmacology. 414: 259-69. PMID 11239927  0.8
2000 Lorrain J, Briand V, Favennec E, Duval N, Grosset A, Janiak P, Hoornaert C, Cremer G, Latham C, O'Connor SE. Pharmacological profile of SL 59.1227, a novel inhibitor of the sodium/hydrogen exchanger. British Journal of Pharmacology. 131: 1188-94. PMID 11082127 DOI: 10.1038/sj.bjp.0703671  0.8
2000 Galzin AM, Delahaye M, Hoornaert C, McCort G, O'Connor SE. Effects of SL 65.0472, a novel 5-HT receptor antagonist, on 5-HT receptor mediated vascular contraction. European Journal of Pharmacology. 404: 361-8. PMID 10996601  0.8
2000 Berry CN, Lunven C, Lecoffre C, Lainée P, O'Connor SE, André F, Roger B, Garrigou-Gadenne D, Rouchouse A, Roome NO, Vivan N. Anticoagulant activity and pharmacokinetic properties of a sub-cutaneously administered mixed micellar formulation of argatroban in experimental animals. Thrombosis and Haemostasis. 84: 278-85. PMID 10959701  0.8
2000 Sgard F, Faure C, Drieu la Rochelle C, Graham D, O'Connor SE, Janiak P, Besnard F. Regulation of ATP-sensitive potassium channel mRNA expression in rat kidney following ischemic injury. Biochemical and Biophysical Research Communications. 269: 618-22. PMID 10708603 DOI: 10.1006/Bbrc.2000.2342  0.8
1999 Imperiali B, O'Connor SE. Effect of N-linked glycosylation on glycopeptide and glycoprotein structure. Current Opinion in Chemical Biology. 3: 643-9. PMID 10600722 DOI: 10.1016/S1367-5931(99)00021-6  1
1999 O'Connor SE, Pearce J, Smith RL, Vogeli D, Walton P. Monitoring the quality of pre-registration education: development, validation and piloting of competency based performance indicators for newly qualified nurses. Nurse Education Today. 19: 334-41. PMID 10595070 DOI: 10.1054/nedt.1999.0645  0.8
1999 Fernández ML, Durán HA, O'Connor SE, Cabrini RL, Molinari BL. Role of distinct subpopulations of peritoneal macrophages in the regulation of reactive oxygen species release. Free Radical Biology & Medicine. 27: 797-809. PMID 10515584  0.8
1999 O'Connor SE, Grosset A, Janiak P. The pharmacological basis and pathophysiological significance of the heart rate-lowering property of diltiazem. Fundamental & Clinical Pharmacology. 13: 145-53. PMID 10226758  0.8
1998 Berry CN, Lunven C, Lechaire I, Girardot C, O'Connor SE. Antithrombotic activity of a monoclonal antibody inducing the substrate form of plasminogen activator inhibitor type 1 in rat models of venous and arterial thrombosis. British Journal of Pharmacology. 125: 29-34. PMID 9776340 DOI: 10.1038/sj.bjp.0702030  0.8
1998 O'Connor SE, Imperiali B. A molecular basis for glycosylation-induced conformational switching Chemistry and Biology. 5: 427-437. PMID 9710565 DOI: 10.1016/S1074-5521(98)90159-4  1
1998 Imperiali B, O'Connor SE. The conformational basis of asparagine-linked glycosylation Pure and Applied Chemistry. 70: 33-40. DOI: 10.1351/Pac199870010033  1
1997 Duval N, Grosset A, O'Connor SE. Combination of aspirin and metoclopramide produces a synergistic antithrombotic effect in a canine model of coronary artery thrombosis. Fundamental & Clinical Pharmacology. 11: 57-62. PMID 9182077  0.8
1997 O'Connor SE, Imperiali B. Conformational switching by asparagine-linked glycosylation Journal of the American Chemical Society. 119: 2295-2296. DOI: 10.1021/Ja963435O  1
1996 O'Connor SE, Imperiali B. Modulation of protein structure and function by asparagine-linked glycosylation. Chemistry & Biology. 3: 803-12. PMID 8939697 DOI: 10.1016/S1074-5521(96)90064-2  1
1996 Choppin A, O'Connor SE. Influence of vascular tone on vasoconstrictor responses to the 5-HT 1-like receptor agonist sumatriptan in anaesthetised rabbits. European Journal of Pharmacology. 304: 87-92. PMID 8813588  0.8
1996 Duval N, Lunven C, O'Brien DP, Grosset A, O'Connor SE, Berry CN. Antithrombotic actions of the thrombin inhibitor, argatroban, in a canine model of coronary cyclic flow: comparison with heparin. British Journal of Pharmacology. 118: 727-33. PMID 8762100  0.8
1996 O'Connor SE. Stroke units: centres of nursing innovation. British Journal of Nursing (Mark Allen Publishing). 5: 105-9. PMID 8680243 DOI: 10.12968/bjon.1996.5.2.105  0.8
1995 Drieu la Rochelle C, O'Connor SE. Sumatriptan-induced saphenous venoconstriction in the anaesthetized dog through 5-HT1-like receptor activation. British Journal of Pharmacology. 116: 2207-12. PMID 8564250  0.8
1995 Choppin A, O'Connor SE. Presence of vasoconstrictor 5HT1-like receptors revealed by precontraction of rabbit isolated mesenteric artery. British Journal of Pharmacology. 114: 309-14. PMID 7881730  0.8
1994 Choppin A, O'Connor SE. 5-Hydroxytryptamine1D-like receptors mediate contraction of partially depolarized rabbit renal arteries. The Journal of Pharmacology and Experimental Therapeutics. 270: 650-5. PMID 8071857  0.8
1994 Drieu la Rochelle CD, Grosset A, O'Connor SE. Comparison of the haemodynamic profiles of elgodipine and nicardipine in the anaesthetized dog. British Journal of Pharmacology. 111: 49-56. PMID 8012724  0.8
1994 O'Connor SE. A reorganisation that improves patient care. An evaluation of team nursing in acute clinical settings. Professional Nurse (London, England). 9: 808-11. PMID 7938063  0.8
1994 O'Connor SE. The development of stroke units: the British experience. Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses. 19: 244-7. PMID 7831527  0.8
1993 Fillinger MF, O'Connor SE, Wagner RJ, Cronenwett JL. The effect of endothelial cell coculture on smooth muscle cell proliferation. Journal of Vascular Surgery. 17: 1058-67; discussion . PMID 8505784  0.8
1993 Choppin A, O'Connor SE. Pre-contraction with histamine and U46619 unmasks a 5-HT1-like receptor in rabbit renal artery. European Journal of Pharmacology. 231: 469-72. PMID 8449238  0.8
1993 Leff P, Wood BE, O'Connor SE, McKechnie K. Quantitative analysis of the agonist and antagonist actions of some ATP analogues at P2X-purinoceptors in the rabbit ear artery. British Journal of Pharmacology. 108: 490-6. PMID 8448598  0.8
1993 O'Connor SE. Evaluating the implementation of team nursing in a clinical setting. British Journal of Nursing (Mark Allen Publishing). 2: 542-7. PMID 8324355  0.8
1993 Lefèvre-Borg F, O'Connor SE, Schoemaker H, Hicks PE, Lechaire J, Gautier E, Pierre F, Pimoule C, Manoury P, Langer SZ. Alfuzosin, a selective alpha 1-adrenoceptor antagonist in the lower urinary tract. British Journal of Pharmacology. 109: 1282-9. PMID 8104650 DOI: 10.1111/j.1476-5381.1993.tb13762.x  0.8
1992 Lorrain J, Grosset A, O'Connor SE. 5-HT4 receptors, present in piglet atria and sensitive to SDZ 205-557, are absent in papillary muscle. European Journal of Pharmacology. 229: 105-8. PMID 1473559  0.8
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