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Christian Hertweck, Prof. Dr. - Publications

Affiliations: 
HKI Jena 
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Year Citation  Score
2023 Joch M, Wojtas KP, Torres-Gómez H, Li Y, Meyer F, Straßburger M, Kerndl V, Dahse HM, Hertweck C, Hoffmann H, Görls H, Walter K, Hölscher C, Kloss F. Whole cell hydride Meisenheimer complex biotransformation guided optimization of antimycobacterial benzothiazinones. European Journal of Medicinal Chemistry. 264: 116023. PMID 38071794 DOI: 10.1016/j.ejmech.2023.116023  0.675
2023 Mlotek MD, Dose B, Hertweck C. Bacterial Isothiocyanate Biosynthesis by Rhodanese-Catalyzed Sulfur Transfer onto Isonitriles. Chembiochem : a European Journal of Chemical Biology. 25: e202300732. PMID 37917130 DOI: 10.1002/cbic.202300732  0.308
2023 Ehinger F, Niehs S, Dose B, Dell M, Krabe J, Pidot SJ, Stinear TP, Scherlach K, Ross C, Lackner G, Hertweck C. Analysis of Rhizonin Biosynthesis Reveals Origin of Pharmacophoric Furylalanine Moieties in Diverse Cyclopeptides. Angewandte Chemie (International Ed. in English). e202308540. PMID 37650335 DOI: 10.1002/anie.202308540  0.648
2023 Götze S, Vij R, Burow K, Thome N, Urbat L, Schlosser N, Pflanze S, Müller R, Hänsch VG, Schlabach K, Fazlikhani L, Walther G, Dahse HM, Regestein L, Brunke S, ... ... Hertweck C, et al. Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block. Journal of the American Chemical Society. 145: 2342-2353. PMID 36669196 DOI: 10.1021/jacs.2c11107  0.312
2022 Niehs SP, Scherlach K, Dose B, Uzum Z, Stinear TP, Pidot SJ, Hertweck C. A highly conserved gene locus in endofungal bacteria codes for the biosynthesis of symbiosis-specific cyclopeptides. Pnas Nexus. 1: pgac152. PMID 36714835 DOI: 10.1093/pnasnexus/pgac152  0.325
2022 Trottmann F, Ishida K, Ishida-Ito M, Kries H, Groll M, Hertweck C. Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead. Nature Chemistry. 14: 884-890. PMID 35906404 DOI: 10.1038/s41557-022-01005-z  0.424
2022 Haensch VG, Neuwirth T, Bergner A, Bruhnke J, Kloss F, Hertweck C. Sustainable and highly controlled aryl couplings revealed by systematic assessment of photoactivatable linkers. Chemical Science. 13: 5680-5686. PMID 35694362 DOI: 10.1039/d2sc00886f  0.684
2022 Horch T, Molloy EM, Bredy F, Haensch VG, Scherlach K, Dunbar KL, Franke J, Hertweck C. Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold. Angewandte Chemie (International Ed. in English). e202205409. PMID 35656913 DOI: 10.1002/anie.202205409  0.449
2022 Krumbholz J, Ishida K, Baunach M, Teikari JE, Rose MM, Sasso S, Hertweck C, Dittmann E. Deciphering Chemical Mediators Regulating Specialized Metabolism in a Symbiotic Cyanobacterium. Angewandte Chemie (International Ed. in English). e202204545. PMID 35403785 DOI: 10.1002/anie.202204545  0.666
2021 Krespach MKC, Stroe MC, Flak M, Komor AJ, Nietzsche S, Sasso S, Hertweck C, Brakhage AA. Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34740967 DOI: 10.1073/pnas.2100892118  0.642
2021 Hotter V, Zopf D, Kim HJ, Silge A, Schmitt M, Aiyar P, Fleck J, Matthäus C, Hniopek J, Yan Q, Loper J, Sasso S, Hertweck C, Popp J, Mittag M. A polyyne toxin produced by an antagonistic bacterium blinds and lyses a Chlamydomonad alga. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34389682 DOI: 10.1073/pnas.2107695118  0.669
2021 Rose MM, Scheer D, Hou Y, Hotter VS, Komor AJ, Aiyar P, Scherlach K, Vergara F, Yan Q, Loper JE, Jakob T, van Dam NM, Hertweck C, Mittag M, Sasso S. The bacterium Pseudomonas protegens antagonizes the microalga Chlamydomonas reinhardtii using a blend of toxins. Environmental Microbiology. PMID 34347373 DOI: 10.1111/1462-2920.15700  0.634
2021 Mullins AJ, Webster G, Kim HJ, Zhao J, Petrova YD, Ramming CE, Jenner M, Murray JAH, Connor TR, Hertweck C, Challis GL, Mahenthiralingam E. Discovery of the Pseudomonas Polyyne Protegencin by a Phylogeny-Guided Study of Polyyne Biosynthetic Gene Cluster Diversity. Mbio. e0071521. PMID 34340549 DOI: 10.1128/mBio.00715-21  0.441
2021 Dose B, Thongkongkaew T, Zopf D, Kim HJ, Bratovanov EV, Pérez MG, Scherlach K, Krabbe J, Ross C, Hermenau R, Niehs SP, Silge A, Hniopek J, Schmitt M, Popp J, ... Hertweck C, et al. Multimodal Molecular Imaging and Identification of Bacterial Toxins Causing Mushroom Soft Rot and Cavity Disease. Chembiochem : a European Journal of Chemical Biology. PMID 34232540 DOI: 10.1002/cbic.202100330  0.795
2021 Liu M, Ohashi M, Hung YS, Scherlach K, Watanabe K, Hertweck C, Tang Y. AoiQ Catalyzes Geminal Dichlorination of 1,3-Diketone Natural Products. Journal of the American Chemical Society. PMID 33957045 DOI: 10.1021/jacs.1c02868  0.495
2021 Dose B, Niehs SP, Scherlach K, Shahda S, Flórez LV, Kaltenpoth M, Hertweck C. Biosynthesis of Sinapigladioside, an Antifungal Isothiocyanate from Burkholderia Symbionts. Chembiochem : a European Journal of Chemical Biology. PMID 33739557 DOI: 10.1002/cbic.202100089  0.309
2020 Tsunematsu Y, Maeda N, Sato M, Hara K, Hashimoto H, Watanabe K, Hertweck C. Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis. Journal of the American Chemical Society. PMID 33351612 DOI: 10.1021/jacs.0c08879  0.719
2020 Hermenau R, Kugel S, Komor AJ, Hertweck C. Helper bacteria halt and disarm mushroom pathogens by linearizing structurally diverse cyclolipopeptides. Proceedings of the National Academy of Sciences of the United States of America. PMID 32868430 DOI: 10.1073/Pnas.2006109117  0.42
2020 Scharf DH, Chankhamjon P, Scherlach K, Dworschak J, Roth M, Brakhage AA, Hertweck C. N-Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase. Chembiochem : a European Journal of Chemical Biology. PMID 32835438 DOI: 10.1002/Cbic.202000550  0.357
2020 Krespach MKC, García-Altares M, Flak M, Hanno Schoeler, Scherlach K, Netzker T, Schmalzl A, Mattern DJ, Schroeckh V, Komor A, Mittag M, Hertweck C, Brakhage AA. Lichen-like association of Chlamydomonas reinhardtii and Aspergillus nidulans protects algal cells from bacteria. The Isme Journal. PMID 32753730 DOI: 10.1038/S41396-020-0731-2  0.34
2020 Scherlach K, Hertweck C. Chemical Mediators at the Bacterial-Fungal Interface. Annual Review of Microbiology. PMID 32660387 DOI: 10.1146/Annurev-Micro-012420-081224  0.319
2020 Ding L, Görls H, Hertweck C. Plant-like Cadinane Sesquiterpenes from an Actinobacterial Mangrove Endophyte. Magnetic Resonance in Chemistry : Mrc. PMID 32598052 DOI: 10.1002/Mrc.5070  0.54
2020 Ishida K, Shabuer G, Schieferdecker S, Pidot SJ, Stinear TP, Knuepfer U, Cyrulies M, Hertweck C. Oak-Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32597507 DOI: 10.1002/Chem.202001939  0.406
2020 Niehs SP, Kumpfmüller J, Dose B, Little RF, Ishida K, Florez LV, Kaltenpoth M, Hertweck C. Insect-Associated Bacteria Assemble the Antifungal Butenolide Gladiofungin by Non-Canonical Polyketide Chain Termination. Angewandte Chemie (International Ed. in English). PMID 32588959 DOI: 10.1002/Anie.202005711  0.393
2020 Ding L, Hertweck C. Oxygenated Geosmins and Plant-like Eudesmanes from a Bacterial Mangrove Endophyte. Journal of Natural Products. PMID 32558565 DOI: 10.1021/Acs.Jnatprod.0C00304  0.512
2020 Trottmann F, Ishida K, Franke J, Stanišić A, Ishida-Ito M, Kries H, Pohnert G, Hertweck C. Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor. Angewandte Chemie (International Ed. in English). PMID 32314848 DOI: 10.1002/Anie.202003958  0.778
2020 Dunbar KL, Dell M, Gude F, Hertweck C. Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32265283 DOI: 10.1073/Pnas.1918759117  0.403
2020 Waterworth SC, Flórez LV, Rees ER, Hertweck C, Kaltenpoth M, Kwan JC. Horizontal Gene Transfer to a Defensive Symbiont with a Reduced Genome in a Multipartite Beetle Microbiome. Mbio. 11. PMID 32098813 DOI: 10.1128/Mbio.02430-19  0.375
2020 Stroe MC, Netzker T, Scherlach K, Krüger T, Hertweck C, Valiante V, Brakhage AA. Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin. Elife. 9. PMID 32083553 DOI: 10.7554/Elife.52541  0.403
2020 Niehs SP, Dose B, Richter S, Pidot SJ, Dahse HM, Stinear TP, Hertweck C. Mining Symbionts of Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones. Angewandte Chemie (International Ed. in English). PMID 32040253 DOI: 10.1002/Anie.201916007  0.427
2020 Stroe MC, Netzker T, Scherlach K, Krüger T, Hertweck C, Valiante V, Brakhage AA. Author response: Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin Elife. DOI: 10.7554/Elife.52541.Sa2  0.324
2019 Costa JH, Wassano CI, Angolini CFF, Scherlach K, Hertweck C, Pacheco Fill T. Antifungal potential of secondary metabolites involved in the interaction between citrus pathogens. Scientific Reports. 9: 18647. PMID 31819142 DOI: 10.1038/S41598-019-55204-9  0.387
2019 Bratovanov EV, Ishida K, Heinze B, Pidot SJ, Stinear TP, Hegemann JD, Marahiel MA, Hertweck C. Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria. Acs Chemical Biology. PMID 31800204 DOI: 10.1021/Acschembio.9B00805  0.367
2019 Lenz C, Wick J, Braga D, Garcia-Altares M, Lackner G, Hertweck C, Gressler M, Hoffmeister D. Injury-Triggered Blueing Reactions of Psilocybe "Magic" Mushrooms. Angewandte Chemie (International Ed. in English). PMID 31725937 DOI: 10.1002/Anie.201910175  0.611
2019 Herisse M, Ishida K, Porter JL, Howden B, Hertweck C, Stinear TP, Pidot SJ. Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic Isolate. Acs Chemical Biology. PMID 31697466 DOI: 10.1021/Acschembio.9B00763  0.394
2019 Haensch VG, Neuwirth T, Steinmetzer J, Kloss F, Beckert R, Gräfe S, Kupfer S, Hertweck C. Metal-Free Aryl Cross-Coupling Directed by Traceless Linkers. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31621964 DOI: 10.1002/Chem.201903582  0.708
2019 Peng H, Ishida K, Hertweck C. Loss of Single Domain Function in Modular Assembly Line Alters Size and Shape of Complex Polyketide. Angewandte Chemie (International Ed. in English). PMID 31595618 DOI: 10.1002/Anie.201911315  0.418
2019 Peng H, Ishida K, Sugimoto Y, Jenke-Kodama H, Hertweck C. Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases. Nature Communications. 10: 3918. PMID 31477708 DOI: 10.1038/S41467-019-11896-1  0.437
2019 Braga D, Last D, Hasan M, Guo H, Leichnitz D, Uzum Z, Richter I, Schalk F, Beemelmanns C, Hertweck C, Lackner G. Metabolic pathway rerouting in evolved long-overlooked derivatives of coenzyme F. Acs Chemical Biology. PMID 31469543 DOI: 10.1021/Acschembio.9B00605  0.596
2019 Trottmann F, Franke J, Richter I, Ishida K, Cyrulies M, Dahse HM, Regenstein L, Hertweck C. A Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species. Angewandte Chemie (International Ed. in English). PMID 31353766 DOI: 10.1002/Anie.201907324  0.768
2019 Niehs SP, Dose B, Scherlach K, Pidot SJ, Stinear TP, Hertweck C. Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal-Bacterial Symbiosis. Acs Chemical Biology. PMID 31283172 DOI: 10.1021/Acschembio.9B00406  0.427
2019 Hermenau R, Mehl JL, Ishida K, Dosa B, Pidot SJ, Stinear TP, Hertweck C. Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria. Angewandte Chemie (International Ed. in English). PMID 31276269 DOI: 10.1002/Anie.201906326  0.346
2019 Dunbar KL, Dell M, Molloy EM, Kloss F, Hertweck C. Reconstitution of Iterative Thioamidation in Closthioamide Biosynthesis Reveals a Novel Nonribosomal Peptide Backbone-Tailoring Strategy. Angewandte Chemie (International Ed. in English). PMID 31276268 DOI: 10.1002/Anie.201905992  0.73
2019 Schieferdecker S, Shabuer G, Letzel AC, Urbansky B, Ishida-Ito M, Ishida K, Cyrulies M, Dahse HM, Pidot S, Hertweck C. Biosynthesis of Diverse Antimicrobial and Antiproliferative Acyloins in Anaerobic Bacteria. Acs Chemical Biology. PMID 31243958 DOI: 10.1021/Acschembio.9B00228  0.814
2019 Fischer D, Gessner G, Fill TP, Barnett R, Tron K, Dornblut K, Kloss F, Stallforth P, Hube B, Heinemann SH, Hertweck C, Scherlach K, Brunke S. Disruption of membrane integrity by the bacteria-derived antifungal jagaricin. Antimicrobial Agents and Chemotherapy. PMID 31235622 DOI: 10.1128/Aac.00707-19  0.788
2019 Schieferdecker S, Shabuer G, Knuepfer U, Hertweck C. Clostrindolin is an antimycobacterial pyrone alkaloid from Clostridium beijerinckii. Organic & Biomolecular Chemistry. PMID 31168541 DOI: 10.1039/C9Ob00968J  0.452
2019 Dörfer M, Heine D, König S, Gore S, Werz O, Hertweck C, Gressler M, Hoffmeister D. Melleolides impact fungal translation via elongation factor 2. Organic & Biomolecular Chemistry. PMID 31042251 DOI: 10.1039/C9Ob00562E  0.407
2019 König S, Pace S, Pein H, Heinekamp T, Kramer J, Romp E, Straßburger M, Troisi F, Proschak A, Dworschak J, Scherlach K, Rossi A, Sautebin L, Haeggström JZ, Hertweck C, et al. Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B Formation through Inhibition of Leukotriene A Hydrolase. Cell Chemical Biology. PMID 30745237 DOI: 10.1016/J.Chembiol.2019.01.001  0.417
2018 Pancrace C, Ishida K, Briand E, Gatte Pichi D, Weiz AR, Guljamow A, Scalvenzi T, Sassoon N, Hertweck C, Dittmann E, Gugger M. A Unique Biosynthetic Pathway in Bloom-Forming Cyanobacterial Genus Microcystis Jointly Assembles Cytotoxic Aeruginoguanidines and Microguanidines. Acs Chemical Biology. PMID 30556994 DOI: 10.1021/Acschembio.8B00918  0.493
2018 Trottmann F, Franke J, Ishida K, Garcia-Altares M, Hertweck C. A Pair of Bacterial Siderophores Releases and Traps an Intercellular Signal Molecule: An Unusual Case of Natural Nitrone Bioconjugation. Angewandte Chemie (International Ed. in English). PMID 30375753 DOI: 10.1002/Anie.201811131  0.759
2018 Fischer J, Müller SY, Netzker T, Jäger N, Gacek-Matthews A, Scherlach K, Stroe MC, García-Altares M, Pezzini F, Schoeler H, Reichelt M, Gershenzon J, Krespach MK, Shelest E, Schroeckh V, ... ... Hertweck C, et al. Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites. Elife. 7. PMID 30311911 DOI: 10.7554/Elife.40969  0.354
2018 Niehs SP, Scherlach K, Hertweck C. Genomics-driven discovery of a linear lipopeptide promoting host colonization by endofungal bacteria. Organic & Biomolecular Chemistry. PMID 30209475 DOI: 10.1039/C8Ob01515E  0.429
2018 Dunbar K, Büttner H, Molloy E, Dell M, Kumpfmueller J, Hertweck C. Genome Editing Reveals Novel Thiotemplated Assembly of Polythioamide Antibiotics in Anaerobic Bacteria. Angewandte Chemie (International Ed. in English). PMID 30193003 DOI: 10.1002/Anie.201807970  0.373
2018 Mahler L, Wink K, Beulig RJ, Scherlach K, Tovar M, Zang E, Martin K, Hertweck C, Belder D, Roth M. Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria. Scientific Reports. 8: 13087. PMID 30166560 DOI: 10.1038/S41598-018-31263-2  0.318
2018 Dose B, Niehs SP, Scherlach K, Florez LV, Kaltenpoth M, Hertweck C. Unexpected Bacterial Origin of the Antibiotic Icosalide: Two-Tailed Depsipeptide Assembly in Multifarious Burkholderia Symbionts. Acs Chemical Biology. PMID 30160099 DOI: 10.1021/Acschembio.8B00600  0.43
2018 Niehs S, Dose B, Scherlach K, Roth M, Hertweck C. Genomics-Driven Discovery of a Symbiont-Specific Cyclopeptide from Bacteria Residing in the Rice Seedling Blight Fungus. Chembiochem : a European Journal of Chemical Biology. PMID 30113119 DOI: 10.1002/Cbic.201800400  0.387
2018 Tsunematsu Y, Maeda N, Yokoyama M, Chankhamjon P, Watanabe K, Scherlach K, Hertweck C. Enzymatic Amide Tailoring Expedites Unusual Retro-Aldol-Type Amino Acid Conversion to Form Antifungal Cyclopeptide. Angewandte Chemie (International Ed. in English). PMID 30109903 DOI: 10.1002/Anie.201806740  0.715
2018 Scharf DH, Dworschak JD, Chankhamjon P, Scherlach K, Heinekamp T, Brakhage AA, Hertweck C. Reconstitution of Enzymatic Carbon-Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis. Acs Chemical Biology. PMID 30075079 DOI: 10.1021/Acschembio.8B00413  0.347
2018 Hermenau R, Ishida K, Gama S, Hoffmann B, Pfeifer-Leeg M, Plass W, Mohr JF, Wichard T, Saluz HP, Hertweck C. Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system. Nature Chemical Biology. PMID 30061716 DOI: 10.1038/S41589-018-0101-9  0.32
2018 Kloss F, Neuwirth T, Haensch V, Hertweck C. Metal-Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing. Angewandte Chemie (International Ed. in English). PMID 30001481 DOI: 10.1002/Anie.201805961  0.689
2018 Hertweck C. Enzymatic Thioamide Formation in Bacterial Antimetabolite Pathway. Angewandte Chemie (International Ed. in English). PMID 29947149 DOI: 10.1002/Anie.201804158  0.388
2018 Flórez LV, Scherlach K, Miller IJ, Rodrigues A, Kwan JC, Hertweck C, Kaltenpoth M. An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles. Nature Communications. 9: 2478. PMID 29946103 DOI: 10.1038/S41467-018-04955-6  0.393
2018 Sundaram S, Kim HJ, Bauer R, Thongkongkaew T, Heine D, Hertweck C. On-line Polyketide Cyclization into Diverse Medium-Sized Lactones by a Specialized Ketosynthase Domain. Angewandte Chemie (International Ed. in English). PMID 29897642 DOI: 10.1002/Anie.201804991  0.78
2018 Heine D, Holmes NA, Worsley SF, Santos ACA, Innocent TM, Scherlach K, Patrick EH, Yu DW, Murrell JC, Vieria PC, Boomsma JJ, Hertweck C, Hutchings MI, Wilkinson B. Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen. Nature Communications. 9: 2208. PMID 29880868 DOI: 10.1038/S41467-018-04520-1  0.655
2018 Heimerl N, Hommel E, Westermann M, Meichsner D, Lohr M, Hertweck C, Grossman AR, Mittag M, Sasso S. A giant type I polyketide synthase participates in zygospore maturation in Chlamydomonas reinhardtii. The Plant Journal : For Cell and Molecular Biology. PMID 29729034 DOI: 10.1111/Tpj.13948  0.663
2018 Thongkongkaew T, Ding W, Bratovanov E, Oueis E, Garcia-Altares M, Zaburannyi N, Harmrolfs K, Zhang Y, Scherlach K, Müller R, Hertweck C. Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species. Acs Chemical Biology. PMID 29669203 DOI: 10.1021/Acschembio.8B00221  0.804
2018 Kloss F, Neuwirth T, Haensch VG, Hertweck C. Frontispiece: Metal-Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing Angewandte Chemie. 57. DOI: 10.1002/Anie.201884461  0.669
2017 Aiyar P, Schaeme D, García-Altares M, Carrasco Flores D, Dathe H, Hertweck C, Sasso S, Mittag M. Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells. Nature Communications. 8: 1756. PMID 29170415 DOI: 10.1038/S41467-017-01547-8  0.628
2017 Molloy EM, Hertweck C. Antimicrobial discovery inspired by ecological interactions. Current Opinion in Microbiology. 39: 121-127. PMID 29169087 DOI: 10.1016/J.Mib.2017.09.006  0.383
2017 Guljamow A, Kreische M, Ishida K, Liaimer A, Altermark B, Bähr L, Hertweck C, Ehwald R, Dittmann E. High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome. Applied and Environmental Microbiology. PMID 28939609 DOI: 10.1128/Aem.01510-17  0.367
2017 Scherlach K, Hertweck C. Mediators of mutualistic microbe-microbe interactions. Natural Product Reports. PMID 28884173 DOI: 10.1039/C7Np00035A  0.312
2017 Brandenburger E, Gressler M, Leonhardt R, Lackner G, Habel A, Hertweck C, Brock M, Hoffmeister D. A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Applied and Environmental Microbiology. PMID 28842536 DOI: 10.1128/Aem.01478-17  0.653
2017 Kugel S, Baunach M, Baer P, Ishida-Ito M, Sundaram S, Xu Z, Groll M, Hertweck C. Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification. Nature Communications. 8: 15804. PMID 28643772 DOI: 10.1038/Ncomms15804  0.383
2017 Flórez LV, Scherlach K, Gaube P, Ross C, Sitte E, Hermes C, Rodrigues A, Hertweck C, Kaltenpoth M. Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism. Nature Communications. 8: 15172. PMID 28452358 DOI: 10.1038/Ncomms15172  0.356
2017 Brandt P, García-Altares M, Nett M, Hertweck C, Hoffmeister D. Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase. Angewandte Chemie (International Ed. in English). PMID 28440038 DOI: 10.1002/Anie.201700767  0.318
2017 Dunbar KL, Scharf DH, Litomska A, Hertweck C. Enzymatic Carbon-Sulfur Bond Formation in Natural Product Biosynthesis. Chemical Reviews. PMID 28418240 DOI: 10.1021/Acs.Chemrev.6B00697  0.342
2017 Valiante V, Mattern DJ, Schueffler A, Horn F, Walther G, Scherlach K, Petzke L, Dickhaut J, Guthke R, Hertweck C, Nett M, Thines E, Brakhage AA. Discovery of an extended austinoid biosynthetic pathway in Aspergillus calidoustus. Acs Chemical Biology. PMID 28233494 DOI: 10.1021/Acschembio.7B00003  0.411
2017 Shao Y, Chen B, Sun C, Ishida K, Hertweck C, Boland W. Symbiont-Derived Antimicrobials Contribute to the Control of the Lepidopteran Gut Microbiota. Cell Chemical Biology. 24: 66-75. PMID 28107652 DOI: 10.1016/J.Chembiol.2016.11.015  0.539
2016 Walther E, Boldt S, Kage H, Lauterbach T, Martin K, Roth M, Hertweck C, Sauerbrei A, Schmidtke M, Nett M. Zincophorin - biosynthesis in Streptomyces griseus and antibiotic properties. Gms Infectious Diseases. 4: Doc08. PMID 30671322 DOI: 10.3205/id000026  0.334
2016 Franke J, Hertweck C. Biomimetic Thioesters as Probes for Enzymatic Assembly Lines: Synthesis, Applications, and Challenges. Cell Chemical Biology. PMID 27693058 DOI: 10.1016/J.Chembiol.2016.08.014  0.736
2016 Polke M, Sprenger M, Scherlach K, Albán-Proaño MC, Martin R, Hertweck C, Hube B, Jacobsen ID. A functional link between hyphal maintenance and quorum sensing in Candida albicans. Molecular Microbiology. PMID 27623739 DOI: 10.1111/Mmi.13526  0.313
2016 Chankhamjon P, Tsunematsu Y, Ishida-Ito M, Sasa Y, Meyer F, Boettger-Schmidt D, Urbansky B, Menzel KD, Scherlach K, Watanabe K, Hertweck C. Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme. Angewandte Chemie (International Ed. in English). PMID 27559694 DOI: 10.1002/Anie.201604516  0.719
2016 De Felice A, Di Lorenzo F, Scherlach K, Ross C, Silipo A, Hertweck C, Molinaro A. Structural investigation of the lipopolysaccharide O-chain isolated from Burkholderia fungorum strain DSM 17061. Carbohydrate Research. 433: 31-35. PMID 27434832 DOI: 10.1016/J.Carres.2016.07.008  0.32
2016 Guo H, Kreuzenbeck NB, Otani S, Garcia-Altares M, Dahse HM, Weigel C, Aanen DK, Hertweck C, Poulsen M, Beemelmanns C. Pseudoxylallemycins A-F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802: A Competitor of Fungus-Growing Termite Cultivars. Organic Letters. PMID 27341414 DOI: 10.1021/Acs.Orglett.6B01437  0.327
2016 Geib E, Gressler M, Viediernikova I, Hillmann F, Jacobsen ID, Nietzsche S, Hertweck C, Brock M. A Non-canonical Melanin Biosynthesis Pathway Protects Aspergillus terreus Conidia from Environmental Stress. Cell Chemical Biology. PMID 27133313 DOI: 10.1016/J.Chembiol.2016.03.014  0.374
2016 Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. Cell Chemical Biology: Home of Exciting Chemical Biology. Cell Chemical Biology. 23: 1-2. PMID 26933730 DOI: 10.1016/J.Chembiol.2016.01.001  0.324
2016 Dolatabadi S, Scherlach K, Figge M, Hertweck C, Dijksterhuis J, Menken SB, de Hoog GS. Food preparation with mucoralean fungi: A potential biosafety issue? Fungal Biology. 120: 393-401. PMID 26895868 DOI: 10.1016/J.Funbio.2015.12.001  0.328
2016 Barnes EC, Jumpathong J, Lumyong S, Voigt K, Hertweck C. Daldionin, an Unprecedented Binaphthyl Derivative, and Diverse Polyketide Congeners from a Fungal Orchid Endophyte. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26880363 DOI: 10.1002/Chem.201504005  0.796
2016 Sundaram S, Hertweck C. On-line enzymatic tailoring of polyketides and peptides in thiotemplate systems. Current Opinion in Chemical Biology. 31: 82-94. PMID 26859622 DOI: 10.1016/J.Cbpa.2016.01.012  0.315
2016 Heine D, Sundaram S, Beudert M, Martin K, Hertweck C. A widespread bacterial phenazine forms S-conjugates with biogenic thiols and crosslinks proteins Chemical Science. 7: 4848-4855. DOI: 10.1039/C6Sc00503A  0.331
2016 Sun Y, Meng Z, Chen P, Zhang D, Baunach M, Hertweck C, Li A. A concise total synthesis of sespenine, a structurally unusual indole terpenoid from Streptomyces Organic Chemistry Frontiers. 3: 368-374. DOI: 10.1039/C5Qo00416K  0.344
2015 Zocher G, Vilstrup J, Heine D, Hallab A, Goralski E, Hertweck C, Stahl M, Schäberle TF, Stehle T. Structural basis of head to head polyketide fusion by CorB. Chemical Science. 6: 6525-6536. PMID 28757960 DOI: 10.1039/C5Sc02488A  0.325
2015 Wick J, Heine D, Lackner G, Misiek M, Tauber J, Jagusch H, Hertweck C, Hoffmeister D. A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (honey mushroom) toxins. Applied and Environmental Microbiology. PMID 26655762 DOI: 10.1128/Aem.03168-15  0.658
2015 Ding L, Goerls H, Dornblut K, Lin W, Maier A, Fiebig HH, Hertweck C. Bacaryolanes A-C, Rare Bacterial Caryolanes from a Mangrove Endophyte. Journal of Natural Products. PMID 26611524 DOI: 10.1021/Acs.Jnatprod.5B00674  0.522
2015 Shabuer G, Ishida K, Pidot SJ, Roth M, Dahse HM, Hertweck C. Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science (New York, N.Y.). 350: 670-4. PMID 26542569 DOI: 10.1126/Science.Aac9990  0.349
2015 Braesel J, Götze S, Shah F, Heine D, Tauber J, Hertweck C, Tunlid A, Stallforth P, Hoffmeister D. Three Redundant Synthetases Secure Redox-Active Pigment Production in the Basidiomycete Paxillus involutus. Chemistry & Biology. 22: 1325-34. PMID 26496685 DOI: 10.1016/J.Chembiol.2015.08.016  0.342
2015 Baunach M, Ding L, Willing K, Hertweck C. Bacterial Synthesis of Unusual Sulfonamide and Sulfone Antibiotics by Flavoenzyme-Mediated Sulfur Dioxide Capture. Angewandte Chemie (International Ed. in English). PMID 26366473 DOI: 10.1002/Anie.201506541  0.579
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Hertweck C, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890  0.771
2015 Chiriac AI, Kloss F, Krämer J, Vuong C, Hertweck C, Sahl HG. Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors. The Journal of Antimicrobial Chemotherapy. 70: 2576-88. PMID 26174721 DOI: 10.1093/Jac/Dkv161  0.714
2015 Gressler M, Meyer F, Heine D, Hortschansky P, Hertweck C, Brock M. Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals. Elife. 4. PMID 26173180 DOI: 10.7554/Elife.07861  0.324
2015 Heine D, Sundaram S, Bretschneider T, Hertweck C. Twofold polyketide branching by a stereoselective enzymatic Michael addition. Chemical Communications (Cambridge, England). 51: 9872-5. PMID 25994388 DOI: 10.1039/C5Cc03085D  0.336
2015 Graupner K, Lackner G, Hertweck C. Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium agaricidamnosum. Genome Announcements. 3. PMID 25883287 DOI: 10.1128/Genomea.00277-15  0.634
2015 Franke J, Ishida K, Hertweck C. Plasticity of the malleobactin pathway and its impact on siderophore action in human pathogenic bacteria. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 8010-4. PMID 25873483 DOI: 10.1002/Chem.201500757  0.758
2015 Hertweck C. Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology. Trends in Biochemical Sciences. 40: 189-99. PMID 25757401 DOI: 10.1016/J.Tibs.2015.02.001  0.357
2015 Barnes EC, Bezerra-Gomes P, Nett M, Hertweck C. Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus. The Journal of Antibiotics. PMID 25690358 DOI: 10.1038/Ja.2015.10  0.724
2015 Sugimoto Y, Ishida K, Traitcheva N, Busch B, Dahse HM, Hertweck C. Freedom and constraint in engineered noncolinear polyketide assembly lines. Chemistry & Biology. 22: 229-40. PMID 25660274 DOI: 10.1016/J.Chembiol.2014.12.014  0.307
2015 Liaimer A, Helfrich EJ, Hinrichs K, Guljamow A, Ishida K, Hertweck C, Dittmann E. Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme. Proceedings of the National Academy of Sciences of the United States of America. 112: 1862-7. PMID 25624477 DOI: 10.1073/Pnas.1419543112  0.306
2015 Horn F, Habel A, Scharf DH, Dworschak J, Brakhage AA, Guthke R, Hertweck C, Linde J. Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announcements. 3. PMID 25614560 DOI: 10.1128/Genomea.01439-14  0.313
2015 Macheleidt J, Scherlach K, Neuwirth T, Schmidt-Heck W, Straßburger M, Spraker J, Baccile JA, Schroeder FC, Keller NP, Hertweck C, Heinekamp T, Brakhage AA. Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus. Molecular Microbiology. 96: 148-62. PMID 25582336 DOI: 10.1111/Mmi.12926  0.395
2015 Uzum Z, Silipo A, Lackner G, De Felice A, Molinaro A, Hertweck C. Structure, genetics and function of an exopolysaccharide produced by a bacterium living within fungal hyphae. Chembiochem : a European Journal of Chemical Biology. 16: 387-92. PMID 25530287 DOI: 10.1002/Cbic.201402488  0.633
2015 Baunach M, Franke J, Hertweck C. Terpenoid biosynthesis off the beaten track: unconventional cyclases and their impact on biomimetic synthesis. Angewandte Chemie (International Ed. in English). 54: 2604-26. PMID 25488271 DOI: 10.1002/Anie.201407883  0.716
2015 Ding L, Franke J, Hertweck C. Divergolide congeners illuminate alternative reaction channels for ansamycin diversification. Organic & Biomolecular Chemistry. 13: 1618-23. PMID 25464499 DOI: 10.1039/C4Ob02244K  0.754
2014 Letzel AC, Pidot SJ, Hertweck C. Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria. Bmc Genomics. 15: 983. PMID 25407095 DOI: 10.1186/1471-2164-15-983  0.368
2014 Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C. Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. Angewandte Chemie (International Ed. in English). 53: 13409-13. PMID 25302411 DOI: 10.1002/Anie.201407624  0.649
2014 Kloss F, Chiriac AI, Hertweck C. Mapping of the modular closthioamide architecture reveals crucial motifs of polythioamide antibiotics. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 15451-8. PMID 25284750 DOI: 10.1002/Chem.201403836  0.724
2014 Ross C, Opel V, Scherlach K, Hertweck C. Biosynthesis of antifungal and antibacterial polyketides by Burkholderia gladioli in coculture with Rhizopus microsporus. Mycoses. 57: 48-55. PMID 25250879 DOI: 10.1111/Myc.12246  0.426
2014 Heine D, Bretschneider T, Sundaram S, Hertweck C. Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles. Angewandte Chemie (International Ed. in English). 53: 11645-9. PMID 25214315 DOI: 10.1002/Anie.201407282  0.315
2014 Moebius N, Üzüm Z, Dijksterhuis J, Lackner G, Hertweck C. Active invasion of bacteria into living fungal cells. Elife. 3: e03007. PMID 25182414 DOI: 10.7554/Elife.03007  0.648
2014 Scharf DH, Habel A, Heinekamp T, Brakhage AA, Hertweck C. Opposed effects of enzymatic gliotoxin N- and S-methylations. Journal of the American Chemical Society. 136: 11674-9. PMID 25062268 DOI: 10.1021/Ja5033106  0.357
2014 Ross C, Scherlach K, Kloss F, Hertweck C. The molecular basis of conjugated polyyne biosynthesis in phytopathogenic bacteria. Angewandte Chemie (International Ed. in English). 53: 7794-8. PMID 24898429 DOI: 10.1002/Anie.201403344  0.75
2014 Xu Z, Baunach M, Ding L, Peng H, Franke J, Hertweck C. Biosynthetic code for divergolide assembly in a bacterial mangrove endophyte. Chembiochem : a European Journal of Chemical Biology. 15: 1274-9. PMID 24867126 DOI: 10.1002/Cbic.201402071  0.794
2014 Pidot S, Ishida K, Cyrulies M, Hertweck C. Discovery of clostrubin, an exceptional polyphenolic polyketide antibiotic from a strictly anaerobic bacterium. Angewandte Chemie (International Ed. in English). 53: 7856-9. PMID 24827417 DOI: 10.1002/anie.201402632  0.808
2014 Zaehle C, Gressler M, Shelest E, Geib E, Hertweck C, Brock M. Terrein biosynthesis in Aspergillus terreus and its impact on phytotoxicity. Chemistry & Biology. 21: 719-31. PMID 24816227 DOI: 10.1016/J.Chembiol.2014.03.010  0.394
2014 Franke J, Ishida K, Hertweck C. Evolution of siderophore pathways in human pathogenic bacteria. Journal of the American Chemical Society. 136: 5599-602. PMID 24707815 DOI: 10.1021/Ja501597W  0.761
2014 Jaschinski T, Helfrich EJ, Bock C, Wolfram S, Svatoš A, Hertweck C, Pohnert G. Matrix-free single-cell LDI-MS investigations of the diatoms Coscinodiscus granii and Thalassiosira pseudonana. Journal of Mass Spectrometry : Jms. 49: 136-44. PMID 24677306 DOI: 10.1002/Jms.3316  0.504
2014 Heine D, Martin K, Hertweck C. Genomics-guided discovery of endophenazines from Kitasatospora sp. HKI 714. Journal of Natural Products. 77: 1083-7. PMID 24617951 DOI: 10.1021/Np400915P  0.385
2014 Weiz AR, Ishida K, Quitterer F, Meyer S, Kehr JC, Müller KM, Groll M, Hertweck C, Dittmann E. Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions. Angewandte Chemie (International Ed. in English). 53: 3735-8. PMID 24591244 DOI: 10.1002/Anie.201309721  0.319
2014 Coyne S, Litomska A, Chizzali C, Khalil MN, Richter K, Beerhues L, Hertweck C. Control of plant defense mechanisms and fire blight pathogenesis through the regulation of 6-thioguanine biosynthesis in Erwinia amylovora. Chembiochem : a European Journal of Chemical Biology. 15: 373-6. PMID 24449489 DOI: 10.1002/Cbic.201300684  0.317
2014 Scharf DH, Groll M, Habel A, Heinekamp T, Hertweck C, Brakhage AA, Huber EM. Flavoenzyme-catalyzed formation of disulfide bonds in natural products. Angewandte Chemie (International Ed. in English). 53: 2221-4. PMID 24446392 DOI: 10.1002/Anie.201309302  0.375
2014 Sugimoto Y, Ding L, Ishida K, Hertweck C. Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line. Angewandte Chemie (International Ed. in English). 53: 1560-4. PMID 24402879 DOI: 10.1002/Anie.201308176  0.541
2014 Gatte-Picchi D, Weiz A, Ishida K, Hertweck C, Dittmann E. Functional analysis of environmental DNA-derived microviridins provides new insights into the diversity of the tricyclic peptide family. Applied and Environmental Microbiology. 80: 1380-7. PMID 24334668 DOI: 10.1128/Aem.03502-13  0.375
2014 Hölscher D, Dhakshinamoorthy S, Alexandrov T, Becker M, Bretschneider T, Buerkert A, Crecelius AC, De Waele D, Elsen A, Heckel DG, Heklau H, Hertweck C, Kai M, Knop K, Krafft C, et al. Phenalenone-type phytoalexins mediate resistance of banana plants (Musa spp.) to the burrowing nematode Radopholus similis. Proceedings of the National Academy of Sciences of the United States of America. 111: 105-10. PMID 24324151 DOI: 10.1073/Pnas.1314168110  0.308
2014 Pidot SJ, Coyne S, Kloss F, Hertweck C. Antibiotics from neglected bacterial sources. International Journal of Medical Microbiology : Ijmm. 304: 14-22. PMID 24120363 DOI: 10.1016/J.Ijmm.2013.08.011  0.726
2014 Moebius N, Üzüm Z, Dijksterhuis J, Lackner G, Hertweck C. Author response: Active invasion of bacteria into living fungal cells Elife. DOI: 10.7554/Elife.03007.020  0.612
2014 Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse H, Hoffmeister D, Hertweck C. Cover Picture: Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion (Angew. Chem. Int. Ed. 49/2014) Angewandte Chemie International Edition. 53: 13295-13295. DOI: 10.1002/Anie.201409948  0.599
2014 Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse H, Hoffmeister D, Hertweck C. Titelbild: Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion (Angew. Chem. 49/2014) Angewandte Chemie. 126: 13511-13511. DOI: 10.1002/Ange.201409948  0.599
2014 Baunach M, Franke J, Hertweck C. Terpenoid-Biosynthese abseits bekannter Wege: unkonventionelle Cyclasen und ihre Bedeutung für die biomimetische Synthese Angewandte Chemie. 127: 2640-2664. DOI: 10.1002/Ange.201407883  0.698
2013 Scherlach K, Lackner G, Graupner K, Pidot S, Bretschneider T, Hertweck C. Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease. Chembiochem : a European Journal of Chemical Biology. 14: 2439-43. PMID 24222604 DOI: 10.1002/Cbic.201300553  0.756
2013 Ueberschaar N, Xu Z, Scherlach K, Metsä-Ketelä M, Bretschneider T, Dahse HM, Görls H, Hertweck C. Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities. Journal of the American Chemical Society. 135: 17408-16. PMID 24143864 DOI: 10.1021/Ja4080024  0.682
2013 Meyer F, Ueberschaar N, Dahse HM, Hertweck C. Synthesis and biological evaluation of hydrazidomycin analogues. Bioorganic & Medicinal Chemistry Letters. 23: 6043-5. PMID 24113061 DOI: 10.1016/J.Bmcl.2013.09.033  0.329
2013 Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C. Vinylogous chain branching catalysed by a dedicated polyketide synthase module. Nature. 502: 124-8. PMID 24048471 DOI: 10.1038/Nature12588  0.556
2013 Kloss F, Pidot S, Goerls H, Friedrich T, Hertweck C. Formation of a dinuclear copper(I) complex from the Clostridium-derived antibiotic closthioamide. Angewandte Chemie (International Ed. in English). 52: 10745-8. PMID 24039060 DOI: 10.1002/Anie.201304714  0.772
2013 Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Willing K, Brakhage AA, Hertweck C. Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges. Angewandte Chemie (International Ed. in English). 52: 11092-5. PMID 24039048 DOI: 10.1002/Anie.201305059  0.339
2013 Coyne S, Chizzali C, Khalil MN, Litomska A, Richter K, Beerhues L, Hertweck C. Biosynthesis of the antimetabolite 6-thioguanine in Erwinia amylovora plays a key role in fire blight pathogenesis. Angewandte Chemie (International Ed. in English). 52: 10564-8. PMID 24038828 DOI: 10.1002/Anie.201305595  0.303
2013 Nützmann HW, Fischer J, Scherlach K, Hertweck C, Brakhage AA. Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Applied and Environmental Microbiology. 79: 6102-9. PMID 23892751 DOI: 10.1128/Aem.01578-13  0.31
2013 Baunach M, Ding L, Bruhn T, Bringmann G, Hertweck C. Regiodivergent N-C and N-N aryl coupling reactions of indoloterpenes and cycloether formation mediated by a single bacterial flavoenzyme. Angewandte Chemie (International Ed. in English). 52: 9040-3. PMID 23843280 DOI: 10.1002/Anie.201303733  0.544
2013 Franke J, Ishida K, Ishida-Ito M, Hertweck C. Nitro versus hydroxamate in siderophores of pathogenic bacteria: effect of missing hydroxylamine protection in malleobactin biosynthesis. Angewandte Chemie (International Ed. in English). 52: 8271-5. PMID 23821334 DOI: 10.1002/Anie.201303196  0.756
2013 Scherlach K, Graupner K, Hertweck C. Molecular bacteria-fungi interactions: effects on environment, food, and medicine. Annual Review of Microbiology. 67: 375-97. PMID 23808337 DOI: 10.1146/Annurev-Micro-092412-155702  0.327
2013 König CC, Scherlach K, Schroeckh V, Horn F, Nietzsche S, Brakhage AA, Hertweck C. Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem : a European Journal of Chemical Biology. 14: 938-42. PMID 23649940 DOI: 10.1002/Cbic.201300070  0.362
2013 Busch B, Ueberschaar N, Behnken S, Sugimoto Y, Werneburg M, Traitcheva N, He J, Hertweck C. Multifactorial control of iteration events in a modular polyketide assembly line. Angewandte Chemie (International Ed. in English). 52: 5285-9. PMID 23606628 DOI: 10.1002/Anie.201301322  0.35
2013 Hennicke F, Grumbt M, Lermann U, Ueberschaar N, Palige K, Böttcher B, Jacobsen ID, Staib C, Morschhäuser J, Monod M, Hube B, Hertweck C, Staib P. Factors supporting cysteine tolerance and sulfite production in Candida albicans. Eukaryotic Cell. 12: 604-13. PMID 23417561 DOI: 10.1128/Ec.00336-12  0.384
2013 Grumbt M, Monod M, Yamada T, Hertweck C, Kunert J, Staib P. Keratin degradation by dermatophytes relies on cysteine dioxygenase and a sulfite efflux pump. The Journal of Investigative Dermatology. 133: 1550-5. PMID 23353986 DOI: 10.1038/Jid.2013.41  0.333
2013 Letzel AC, Pidot SJ, Hertweck C. A genomic approach to the cryptic secondary metabolome of the anaerobic world. Natural Product Reports. 30: 392-428. PMID 23263685 DOI: 10.1039/C2Np20103H  0.4
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Hertweck C, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.766
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Hertweck C, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.764
2013 Meyer F, Ueberschaar N, Hertweck C. Concise total synthesis of hydrazidomycin A, a rare hydrazide metabolite of streptomyces atratus European Journal of Organic Chemistry. 4242-4244. DOI: 10.1002/Ejoc.201300532  0.317
2012 Ding L, Maier A, Fiebig HH, Lin WH, Peschel G, Hertweck C. Kandenols A-E, eudesmenes from an endophytic Streptomyces sp. of the mangrove tree Kandelia candel. Journal of Natural Products. 75: 2223-7. PMID 23234344 DOI: 10.1021/Np300387N  0.524
2012 Ding L, Peschel G, Hertweck C. Biosynthesis of archetypal plant self-defensive oxylipins by an endophytic fungus residing in mangrove embryos. Chembiochem : a European Journal of Chemical Biology. 13: 2661-4. PMID 23165938 DOI: 10.1002/Cbic.201200544  0.486
2012 Graupner K, Scherlach K, Bretschneider T, Lackner G, Roth M, Gross H, Hertweck C. Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angewandte Chemie (International Ed. in English). 51: 13173-7. PMID 23161559 DOI: 10.1002/Anie.201206658  0.639
2012 Franke J, Ishida K, Hertweck C. Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species. Angewandte Chemie (International Ed. in English). 51: 11611-5. PMID 23055407 DOI: 10.1002/Anie.201205566  0.713
2012 Boettger D, Bergmann H, Kuehn B, Shelest E, Hertweck C. Evolutionary imprint of catalytic domains in fungal PKS-NRPS hybrids. Chembiochem : a European Journal of Chemical Biology. 13: 2363-73. PMID 23023987 DOI: 10.1002/Cbic.201200449  0.358
2012 Ding L, Ndejouong Ble S, Maier A, Fiebig HH, Hertweck C. Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708. Journal of Natural Products. 75: 1729-34. PMID 23013356 DOI: 10.1021/Np300329M  0.505
2012 Moebius N, Ross C, Scherlach K, Rohm B, Roth M, Hertweck C. Biosynthesis of the respiratory toxin bongkrekic acid in the pathogenic bacterium Burkholderia gladioli. Chemistry & Biology. 19: 1164-74. PMID 22999884 DOI: 10.1016/J.Chembiol.2012.07.022  0.372
2012 Xu Z, Baunach M, Ding L, Hertweck C. Bacterial synthesis of diverse indole terpene alkaloids by an unparalleled cyclization sequence. Angewandte Chemie (International Ed. in English). 51: 10293-7. PMID 22968942 DOI: 10.1002/Anie.201204087  0.602
2012 Richter M, Busch B, Ishida K, Moore BS, Hertweck C. Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway. Chembiochem : a European Journal of Chemical Biology. 13: 2196-9. PMID 22961965 DOI: 10.1002/Cbic.201200406  0.635
2012 Scherlach K, Busch B, Lackner G, Paszkowski U, Hertweck C. Symbiotic cooperation in the biosynthesis of a phytotoxin. Angewandte Chemie (International Ed. in English). 51: 9615-8. PMID 22915379 DOI: 10.1002/Anie.201204540  0.704
2012 Behnken S, Hertweck C. Anaerobic bacteria as producers of antibiotics. Applied Microbiology and Biotechnology. 96: 61-7. PMID 22854892 DOI: 10.1007/S00253-012-4285-8  0.392
2012 Kusari S, Hertweck C, Spiteller M. Chemical ecology of endophytic fungi: origins of secondary metabolites. Chemistry & Biology. 19: 792-8. PMID 22840767 DOI: 10.1016/J.Chembiol.2012.06.004  0.371
2012 Ishida K, Lincke T, Hertweck C. Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis. Angewandte Chemie (International Ed. in English). 51: 5470-4. PMID 22517609 DOI: 10.1002/Anie.201200067  0.38
2012 Scherlach K, Brendel N, Ishida K, Dahse HM, Hertweck C. Photochemical oxazole-nitrile conversion downstream of rhizoxin biosynthesis and its impact on antimitotic activity. Organic & Biomolecular Chemistry. 10: 5756-9. PMID 22453231 DOI: 10.1039/C2Ob25250C  0.324
2012 Jensen K, Niederkrüger H, Zimmermann K, Vagstad AL, Moldenhauer J, Brendel N, Frank S, Pöplau P, Kohlhaas C, Townsend CA, Oldiges M, Hertweck C, Piel J. Polyketide proofreading by an acyltransferase-like enzyme. Chemistry & Biology. 19: 329-39. PMID 22444588 DOI: 10.1016/J.Chembiol.2012.01.005  0.557
2012 Ding L, Dahse HM, Hertweck C. Cytotoxic alkaloids from Fusarium incarnatum associated with the mangrove tree Aegiceras corniculatum. Journal of Natural Products. 75: 617-21. PMID 22439674 DOI: 10.1021/Np2008544  0.487
2012 Sarkar A, Funk AN, Scherlach K, Horn F, Schroeckh V, Chankhamjon P, Westermann M, Roth M, Brakhage AA, Hertweck C, Horn U. Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. Journal of Biotechnology. 160: 64-71. PMID 22306112 DOI: 10.1016/J.Jbiotec.2012.01.015  0.359
2012 Behnken S, Lincke T, Kloss F, Ishida K, Hertweck C. Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium. Angewandte Chemie (International Ed. in English). 51: 2425-8. PMID 22287490 DOI: 10.1002/Anie.201108214  0.706
2012 Behnken S, Hertweck C. Cryptic polyketide synthase genes in non-pathogenic Clostridium SPP. Plos One. 7: e29609. PMID 22235310 DOI: 10.1371/Journal.Pone.0029609  0.4
2012 Bretschneider T, Zocher G, Unger M, Scherlach K, Stehle T, Hertweck C. A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nature Chemical Biology. 8: 154-61. PMID 22179067 DOI: 10.1038/Nchembio.746  0.367
2012 Silipo A, Leone MR, Lanzetta R, Parrilli M, Lackner G, Busch B, Hertweck C, Molinaro A. Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4). Carbohydrate Research. 347: 95-8. PMID 22115719 DOI: 10.1016/J.Carres.2011.10.038  0.617
2012 Scharf DH, Heinekamp T, Remme N, Hortschansky P, Brakhage AA, Hertweck C. Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Applied Microbiology and Biotechnology. 93: 467-72. PMID 22094977 DOI: 10.1007/S00253-011-3689-1  0.343
2012 Sasso S, Pohnert G, Lohr M, Mittag M, Hertweck C. Microalgae in the postgenomic era: a blooming reservoir for new natural products. Fems Microbiology Reviews. 36: 761-85. PMID 22091538 DOI: 10.1111/J.1574-6976.2011.00304.X  0.732
2011 Liaimer A, Jenke-Kodama H, Ishida K, Hinrichs K, Stangeland J, Hertweck C, Dittmann E. A polyketide interferes with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme. Environmental Microbiology Reports. 3: 550-8. PMID 23761334 DOI: 10.1111/J.1758-2229.2011.00258.X  0.344
2011 Weiz AR, Ishida K, Makower K, Ziemert N, Hertweck C, Dittmann E. Leader peptide and a membrane protein scaffold guide the biosynthesis of the tricyclic peptide microviridin. Chemistry & Biology. 18: 1413-21. PMID 22118675 DOI: 10.1016/J.Chembiol.2011.09.011  0.334
2011 Nett M, Hertweck C. Farinamycin, a quinazoline from Streptomyces griseus. Journal of Natural Products. 74: 2265-8. PMID 21939253 DOI: 10.1021/Np2002513  0.371
2011 Scherlach K, Nützmann HW, Schroeckh V, Dahse HM, Brakhage AA, Hertweck C. Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angewandte Chemie (International Ed. in English). 50: 9843-7. PMID 21913294 DOI: 10.1002/Anie.201104488  0.301
2011 Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, Gershenzon J, Haas H, Brakhage AA. The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Molecular Microbiology. 82: 39-53. PMID 21883519 DOI: 10.1111/J.1365-2958.2011.07778.X  0.321
2011 Ueberschaar N, Ndejouong Ble S, Ding L, Maier A, Fiebig HH, Hertweck C. Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus. Bioorganic & Medicinal Chemistry Letters. 21: 5839-41. PMID 21868221 DOI: 10.1016/J.Bmcl.2011.07.108  0.422
2011 Nützmann HW, Reyes-Dominguez Y, Scherlach K, Schroeckh V, Horn F, Gacek A, Schümann J, Hertweck C, Strauss J, Brakhage AA. Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proceedings of the National Academy of Sciences of the United States of America. 108: 14282-7. PMID 21825172 DOI: 10.1073/Pnas.1103523108  0.386
2011 Scharf DH, Remme N, Habel A, Chankhamjon P, Scherlach K, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C. A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. Journal of the American Chemical Society. 133: 12322-5. PMID 21749092 DOI: 10.1021/Ja201311D  0.321
2011 Lackner G, Hertweck C. Impact of endofungal bacteria on infection biology, food safety, and drug development. Plos Pathogens. 7: e1002096. PMID 21738468 DOI: 10.1371/Journal.Ppat.1002096  0.641
2011 Fries A, Bretschneider T, Winkler R, Hertweck C. A ribonucleotide reductase-like electron transfer system in the nitroaryl-forming N-oxygenase AurF. Chembiochem : a European Journal of Chemical Biology. 12: 1832-5. PMID 21678538 DOI: 10.1002/Cbic.201100138  0.457
2011 Lackner G, Moebius N, Partida-Martinez LP, Boland S, Hertweck C. Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome. Bmc Genomics. 12: 210. PMID 21539752 DOI: 10.1186/1471-2164-12-210  0.81
2011 Ding L, Maier A, Fiebig HH, Lin WH, Hertweck C. A family of multicyclic indolosesquiterpenes from a bacterial endophyte. Organic & Biomolecular Chemistry. 9: 4029-31. PMID 21528153 DOI: 10.1039/C1Ob05283G  0.523
2011 Xu Z, Ding L, Hertweck C. A branched extender unit shared between two orthogonal polyketide pathways in an endophyte. Angewandte Chemie (International Ed. in English). 50: 4667-70. PMID 21506215 DOI: 10.1002/Anie.201008265  0.544
2011 Regueira TB, Kildegaard KR, Hansen BG, Mortensen UH, Hertweck C, Nielsen J. Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum. Applied and Environmental Microbiology. 77: 3035-43. PMID 21398490 DOI: 10.1128/Aem.03015-10  0.382
2011 Vödisch M, Scherlach K, Winkler R, Hertweck C, Braun HP, Roth M, Haas H, Werner ER, Brakhage AA, Kniemeyer O. Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. Journal of Proteome Research. 10: 2508-24. PMID 21388144 DOI: 10.1021/Pr1012812  0.528
2011 Ding L, Maier A, Fiebig HH, Görls H, Lin WH, Peschel G, Hertweck C. Divergolides A-D from a mangrove endophyte reveal an unparalleled plasticity in ansa-macrolide biosynthesis. Angewandte Chemie (International Ed. in English). 50: 1630-4. PMID 21308920 DOI: 10.1002/Anie.201006165  0.483
2011 Zocher G, Richter ME, Mueller U, Hertweck C. Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase. Journal of the American Chemical Society. 133: 2292-302. PMID 21280577 DOI: 10.1021/Ja110146Z  0.313
2011 Gee JE, Glass MB, Lackner G, Helsel LO, Daneshvar M, Hollis DG, Jordan J, Morey R, Steigerwalt A, Hertweck C. Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens. Plos One. 6: e15731. PMID 21267449 DOI: 10.1371/Journal.Pone.0015731  0.631
2011 Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, ... ... Hertweck C, et al. Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biology. 12: R7. PMID 21247460 DOI: 10.1186/Gb-2011-12-1-R7  0.574
2011 Gressler M, Zaehle C, Scherlach K, Hertweck C, Brock M. Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus. Chemistry & Biology. 18: 198-209. PMID 21236704 DOI: 10.1016/J.Chembiol.2010.12.011  0.376
2011 Lackner G, Moebius N, Partida-Martinez L, Hertweck C. Complete genome sequence of Burkholderia rhizoxinica, an Endosymbiont of Rhizopus microsporus. Journal of Bacteriology. 193: 783-4. PMID 21131495 DOI: 10.1128/Jb.01318-10  0.804
2011 Winter JM, Behnken S, Hertweck C. Genomics-inspired discovery of natural products. Current Opinion in Chemical Biology. 15: 22-31. PMID 21111667 DOI: 10.1016/J.Cbpa.2010.10.020  0.691
2011 Lackner G, Moebius N, Hertweck C. Endofungal bacterium controls its host by an hrp type III secretion system. The Isme Journal. 5: 252-61. PMID 20720578 DOI: 10.1038/Ismej.2010.126  0.668
2011 Kloss F, Lincke T, Hertweck C. Highly Efficient Total Synthesis of the Clostridium‐Derived anti‐MRSA Antibiotic Closthioamide (Eur. J. Org. Chem. 8/2011) European Journal of Organic Chemistry. 2011. DOI: 10.1002/Ejoc.201190015  0.716
2011 Kloss F, Lincke T, Hertweck C. Highly efficient total synthesis of the clostridium-derived anti-MRSA antibiotic closthioamide European Journal of Organic Chemistry. 1429-1431. DOI: 10.1002/Ejoc.201001695  0.715
2010 Bergmann S, Funk AN, Scherlach K, Schroeckh V, Shelest E, Horn U, Hertweck C, Brakhage AA. Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster. Applied and Environmental Microbiology. 76: 8143-9. PMID 20952652 DOI: 10.1128/Aem.00683-10  0.346
2010 Ding L, Münch J, Goerls H, Maier A, Fiebig HH, Lin WH, Hertweck C. Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte. Bioorganic & Medicinal Chemistry Letters. 20: 6685-7. PMID 20880706 DOI: 10.1016/J.Bmcl.2010.09.010  0.477
2010 Ishida K, Lincke T, Behnken S, Hertweck C. Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant Journal of the American Chemical Society. 132: 13966-13968. PMID 20853892 DOI: 10.1021/Ja105003G  0.386
2010 Fries A, Winkler R, Hertweck C. Structural and biochemical basis for the firm chemo- and regioselectivity of the nitro-forming N-oxygenase AurF. Chemical Communications (Cambridge, England). 46: 7760-2. PMID 20830374 DOI: 10.1039/C0Cc02811H  0.506
2010 Leone MR, Lackner G, Silipo A, Lanzetta R, Molinaro A, Hertweck C. An unusual galactofuranose lipopolysaccharide that ensures the intracellular survival of toxin-producing bacteria in their fungal host. Angewandte Chemie (International Ed. in English). 49: 7476-80. PMID 20718018 DOI: 10.1002/Anie.201003301  0.638
2010 Gomes PB, Nett M, Dahse HM, Hertweck C. Pitucamycin: Structural merger of a phenoxazinone with an epoxyquinone antibiotic Journal of Natural Products. 73: 1461-1464. PMID 20715808 DOI: 10.1021/Np100344U  0.312
2010 Werneburg M, Busch B, He J, Richter ME, Xiang L, Moore BS, Roth M, Dahse HM, Hertweck C. Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. Journal of the American Chemical Society. 132: 10407-13. PMID 20662518 DOI: 10.1021/Ja102751H  0.68
2010 Bruns S, Seidler M, Albrecht D, Salvenmoser S, Remme N, Hertweck C, Brakhage AA, Kniemeyer O, Müller FMC. Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin Proteomics. 10: 3097-3107. PMID 20645385 DOI: 10.1002/Pmic.201000129  0.378
2010 Scharf DH, Remme N, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C. Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus Journal of the American Chemical Society. 132: 10136-10141. PMID 20593880 DOI: 10.1021/Ja103262M  0.395
2010 Scherlach K, Boettger D, Remme N, Hertweck C. The chemistry and biology of cytochalasans Natural Product Reports. 27: 869-886. PMID 20411198 DOI: 10.1039/B903913A  0.302
2010 Ziemert N, Ishida K, Weiz A, Hertweck C, Dittmann E. Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides Applied and Environmental Microbiology. 76: 3568-3574. PMID 20363789 DOI: 10.1128/Aem.02858-09  0.397
2010 Kroiss J, Kaltenpoth M, Schneider B, Schwinger MG, Hertweck C, Maddula RK, Strohm E, Svatos A. Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring Nature Chemical Biology. 6: 261-263. PMID 20190763 DOI: 10.1038/Nchembio.331  0.386
2010 Lincke T, Behnken S, Ishida K, Roth M, Hertweck C. Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angewandte Chemie (International Ed. in English). 49: 2011-3. PMID 20157900 DOI: 10.1002/Anie.200906114  0.321
2010 Rohm B, Scherlach K, Möbius N, Partida-Martinez LP, Hertweck C. Toxin production by bacterial endosymbionts of a Rhizopus microsporus strain used for tempe/sufu processing. International Journal of Food Microbiology. 136: 368-71. PMID 19942312 DOI: 10.1016/J.Ijfoodmicro.2009.10.010  0.72
2010 Abdou R, Scherlach K, Dahse HM, Sattler I, Hertweck C. Botryorhodines A-D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa Phytochemistry. 71: 110-116. PMID 19913264 DOI: 10.1016/J.Phytochem.2009.09.024  0.328
2009 Lackner G, Partida-Martinez LP, Hertweck C. Endofungal bacteria as producers of mycotoxins. Trends in Microbiology. 17: 570-6. PMID 19800796 DOI: 10.1016/J.Tim.2009.09.003  0.788
2009 Schroeckh V, Scherlach K, Nützmann HW, Shelest E, Schmidt-Heck W, Schuemann J, Martin K, Hertweck C, Brakhage AA. Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans Proceedings of the National Academy of Sciences of the United States of America. 106: 14558-14563. PMID 19666480 DOI: 10.1073/Pnas.0901870106  0.405
2009 Busch B, Hertweck C. Evolution of metabolic diversity in polyketide-derived pyrones: Using the non-colinear aureothin assembly line as a model system Phytochemistry. 70: 1833-1840. PMID 19651421 DOI: 10.1016/J.Phytochem.2009.05.022  0.387
2009 Möbius N, Hertweck C. Fungal phytotoxins as mediators of virulence Current Opinion in Plant Biology. 12: 390-398. PMID 19608453 DOI: 10.1016/J.Pbi.2009.06.004  0.33
2009 Scherlach K, Hertweck C. Triggering cryptic natural product biosynthesis in microorganisms Organic and Biomolecular Chemistry. 7: 1753-1760. PMID 19590766 DOI: 10.1039/B821578B  0.379
2009 Hertweck C. Hidden biosynthetic treasures brought to light Nature Chemical Biology. 5: 450-452. PMID 19536102 DOI: 10.1038/Nchembio0709-450  0.354
2009 Hertweck C. The biosynthetic logic of polyketide diversity Angewandte Chemie - International Edition. 48: 4688-4716. PMID 19514004 DOI: 10.1002/Anie.200806121  0.354
2009 Lackner G, Möbius N, Scherlach K, Partida-Martinez LP, Winkler R, Schmitt I, Hertweck C. Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis. Applied and Environmental Microbiology. 75: 2982-6. PMID 19286793 DOI: 10.1128/Aem.01765-08  0.779
2009 Ishida K, Welker M, Christiansen G, Cadel-Six S, Bouchier C, Dittmann E, Hertweck C, Tandeau de Marsac N. Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria. Applied and Environmental Microbiology. 75: 2017-26. PMID 19201978 DOI: 10.1128/Aem.02258-08  0.353
2009 Xu Z, Metsä-Ketelä M, Hertweck C. Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives. Journal of Biotechnology. 140: 107-13. PMID 19047004 DOI: 10.1016/J.Jbiotec.2008.10.013  0.686
2008 Li YQ, Huang XS, Ishida K, Maier A, Kelter G, Jiang Y, Peschel G, Menzel KD, Li MG, Wen ML, Xu LH, Grabley S, Fiebig HH, Jiang CL, Hertweck C, et al. Plasticity in gilvocarcin-type C-glycoside pathways: Discovery and antitumoral evaluation of polycarcin v from Streptomyces polyformus Organic and Biomolecular Chemistry. 6: 3601-3605. PMID 19082162 DOI: 10.1039/B808633H  0.314
2008 Fritzsche K, Ishida K, Hertweck C. Orchestration of discoid polyketide cyclization in the resistomycin pathway Journal of the American Chemical Society. 130: 8307-8316. PMID 18533655 DOI: 10.1021/Ja800251M  0.385
2008 Brakhage AA, Schuemann J, Bergmann S, Scherlach K, Schroeckh V, Hertweck C. Activation of fungal silent gene clusters: A new avenue to drug discovery Progress in Drug Research. 66: 1-12. PMID 18416304 DOI: 10.1007/978-3-7643-8595-8_1  0.368
2008 Huang X, He J, Niu X, Menzel KD, Dahse HM, Grabley S, Fiedler HP, Sattler I, Hertweck C. Benzopyrenomycin, a cytotoxic bacterial polyketide metabolite with a benzo[a]pyrene-type carbocyclic ring system. Angewandte Chemie (International Ed. in English). 47: 3995-8. PMID 18412200 DOI: 10.1002/Anie.200800083  0.329
2008 Partida-Martinez LP, Bandemer S, Rüchel R, Dannaoui E, Hertweck C. Lack of evidence of endosymbiotic toxin-producing bacteria in clinical Rhizopus isolates. Mycoses. 51: 266-9. PMID 18399908 DOI: 10.1111/J.1439-0507.2007.01477.X  0.731
2008 Schmitt I, Partida-Martinez LP, Winkler R, Voigt K, Einax E, Dölz F, Telle S, Wöstemeyer J, Hertweck C. Evolution of host resistance in a toxin-producing bacterial-fungal alliance. The Isme Journal. 2: 632-41. PMID 18309361 DOI: 10.1038/Ismej.2008.19  0.791
2008 Ziemert N, Ishida K, Quillardet P, Bouchier C, Hertweck C, De Marsac NT, Dittmann E. Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: From structure to genes and vice versa Applied and Environmental Microbiology. 74: 1791-1797. PMID 18245249 DOI: 10.1128/Aem.02392-07  0.395
2008 Nguyen T, Ishida K, Jenke-Kodama H, Dittmann E, Gurgui C, Hochmuth T, Taudien S, Platzer M, Hertweck C, Piel J. Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection Nature Biotechnology. 26: 225-233. PMID 18223641 DOI: 10.1038/Nbt1379  0.581
2007 Partida-Martinez LP, Groth I, Schmitt I, Richter W, Roth M, Hertweck C. Burkholderia rhizoxinica sp. nov. and Burkholderia endofungorum sp. nov., bacterial endosymbionts of the plant-pathogenic fungus Rhizopus microsporus. International Journal of Systematic and Evolutionary Microbiology. 57: 2583-90. PMID 17978222 DOI: 10.1099/Ijs.0.64660-0  0.767
2007 Kemami Wangun HV, Dahse HM, Hertweck C. Epicoccamides B-D, glycosylated tetramic acid derivatives from an Epicoccum sp. associated with the tree fungus Pholiota squarrosa Journal of Natural Products. 70: 1800-1803. PMID 17966985 DOI: 10.1021/Np070245Q  0.309
2007 Winkler R, Zocher G, Richter I, Friedrich T, Schulz GE, Hertweck C. A binuclear manganese cluster that catalyzes radical-mediated N-oxygenation. Angewandte Chemie (International Ed. in English). 46: 8605-8. PMID 17926312 DOI: 10.1002/Anie.200703089  0.479
2007 Ishida K, Fritzsche K, Hertweck C. Geminal tandem C-methylation in the discoid resistomycin pathway Journal of the American Chemical Society. 129: 12648-12649. PMID 17914826 DOI: 10.1021/Ja075524E  0.315
2007 Zocher G, Winkler R, Hertweck C, Schulz GE. Structure and action of the N-oxygenase AurF from Streptomyces thioluteus. Journal of Molecular Biology. 373: 65-74. PMID 17765264 DOI: 10.1016/J.Jmb.2007.06.014  0.529
2007 Traitcheva N, Jenke-Kodama H, He J, Dittmann E, Hertweck C. Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective. Chembiochem : a European Journal of Chemical Biology. 8: 1841-9. PMID 17763486 DOI: 10.1002/Cbic.200700309  0.45
2007 Schenk A, Xu Z, Pfeiffer C, Steinbeck C, Hertweck C. Geminal bismethylation prevents polyketide oxidation and dimerization in the benastatin pathway. Angewandte Chemie (International Ed. in English). 46: 7035-8. PMID 17691088 DOI: 10.1002/Anie.200702033  0.525
2007 Palmu K, Ishida K, Mäntsälä P, Hertweck C, Metsä-Ketelä M. Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways. Chembiochem : a European Journal of Chemical Biology. 8: 1577-84. PMID 17654627 DOI: 10.1002/Cbic.200700140  0.705
2007 Schümann J, Hertweck C. Molecular basis of cytochalasan biosynthesis in fungi: Gene cluster analysis and evidence for the involvement of a PKS-NRPS hybrid synthase by RNA silencing Journal of the American Chemical Society. 129: 9564-9565. PMID 17636916 DOI: 10.1021/Ja072884T  0.337
2007 Lackner G, Schenk A, Xu Z, Reinhardt K, Yunt ZS, Piel J, Hertweck C. Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. Journal of the American Chemical Society. 129: 9306-12. PMID 17625850 DOI: 10.1021/Ja0718624  0.728
2007 Brendel N, Partida-Martinez LP, Scherlach K, Hertweck C. A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex. Organic & Biomolecular Chemistry. 5: 2211-3. PMID 17609750 DOI: 10.1039/B707762A  0.725
2007 Ishida K, Christiansen G, Yoshida WY, Kurmayer R, Welker M, Valls N, Bonjoch J, Hertweck C, Börner T, Hemscheidt T, Dittmann E. Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety. Chemistry & Biology. 14: 565-76. PMID 17524987 DOI: 10.1016/J.Chembiol.2007.04.006  0.381
2007 Kemami Wangun HV, Hertweck C. Epicoccarines A, B and epipyridone: tetramic acids and pyridone alkaloids from an Epicoccum sp. associated with the tree fungus Pholiota squarrosa. Organic & Biomolecular Chemistry. 5: 1702-5. PMID 17520137 DOI: 10.1039/B702378B  0.354
2007 Winkler R, Hertweck C. Biosynthesis of nitro compounds. Chembiochem : a European Journal of Chemical Biology. 8: 973-7. PMID 17477464 DOI: 10.1002/Cbic.200700042  0.415
2007 Hsiao NH, Söding J, Linke D, Lange C, Hertweck C, Wohlleben W, Takano E. ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize γ-butyrolactones Microbiology. 153: 1394-1404. PMID 17464053 DOI: 10.1099/Mic.0.2006/004432-0  0.323
2007 Xu Z, Schenk A, Hertweck C. Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids Journal of the American Chemical Society. 129: 6022-6030. PMID 17439117 DOI: 10.1021/Ja069045B  0.371
2007 Partida-Martinez LP, Monajembashi S, Greulich KO, Hertweck C. Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism. Current Biology : Cb. 17: 773-7. PMID 17412585 DOI: 10.1016/J.Cub.2007.03.039  0.739
2007 Bergmann S, Schümann J, Scherlach K, Lange C, Brakhage AA, Hertweck C. Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nature Chemical Biology. 3: 213-7. PMID 17369821 DOI: 10.1038/Nchembio869  0.397
2007 Partida-Martinez LP, Hertweck C. A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus. Chembiochem : a European Journal of Chemical Biology. 8: 41-5. PMID 17154220 DOI: 10.1002/Cbic.200600393  0.724
2007 Partida-Martinez LP, de Looss CF, Ishida K, Ishida M, Roth M, Buder K, Hertweck C. Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts. Applied and Environmental Microbiology. 73: 793-7. PMID 17122400 DOI: 10.1128/Aem.01784-06  0.743
2007 Partida-Martinez LP, Hertweck C. Cover Picture: A Gene Cluster Encoding Rhizoxin Biosynthesis in “Burkholderia rhizoxina”, the Bacterial Endosymbiont of the FungusRhizopus microsporus (ChemBioChem 1/2007) Chembiochem. 8: 1-1. DOI: 10.1002/Cbic.200690039  0.337
2006 Ishida K, Maksimenka K, Fritzsche K, Scherlach K, Bringmann G, Hertweck C. The boat-shaped polyketide resistoflavin results from re-facial central hydroxylation of the discoid metabolite resistomycin. Journal of the American Chemical Society. 128: 14619-24. PMID 17090047 DOI: 10.1021/Ja064550U  0.309
2006 Winkler R, Richter ME, Knüpfer U, Merten D, Hertweck C. Regio- and chemoselective enzymatic N-oxygenation in vivo, in vitro, and in flow. Angewandte Chemie (International Ed. in English). 45: 8016-8. PMID 17080472 DOI: 10.1002/Anie.200603060  0.447
2006 Scherlach K, Hertweck C. Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining. Organic & Biomolecular Chemistry. 4: 3517-20. PMID 17036148 DOI: 10.1039/B607011F  0.339
2006 Scherlach K, Partida-Martinez LP, Dahse HM, Hertweck C. Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus. Journal of the American Chemical Society. 128: 11529-36. PMID 16939276 DOI: 10.1021/Ja062953O  0.742
2006 Schümann J, Hertweck C. Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes. Journal of Biotechnology. 124: 690-703. PMID 16716432 DOI: 10.1016/J.Jbiotec.2006.03.046  0.364
2006 Müller M, He J, Hertweck C. Dissection of the late steps in aureothin biosynthesis. Chembiochem : a European Journal of Chemical Biology. 7: 37-9. PMID 16292785 DOI: 10.1002/Cbic.200500161  0.366
2005 Partida-Martinez LP, Hertweck C. Pathogenic fungus harbours endosymbiotic bacteria for toxin production. Nature. 437: 884-8. PMID 16208371 DOI: 10.1038/Nature03997  0.738
2005 Herold K, Gollmick FA, Groth I, Roth M, Menzel KD, Möllmann U, Gräfe U, Hertweck C. Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 5523-30. PMID 15940739 DOI: 10.1002/Chem.200500320  0.316
2005 Winkler R, Hertweck C. Sequential enzymatic oxidation of aminoarenes to nitroarenes via hydroxylamines. Angewandte Chemie (International Ed. in English). 44: 4083-7. PMID 15929146 DOI: 10.1002/Anie.200500365  0.444
2005 Xu Z, Jakobi K, Welzel K, Hertweck C. Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide. Chemistry & Biology. 12: 579-88. PMID 15911378 DOI: 10.1016/J.Chembiol.2005.04.017  0.377
2005 He J, Hertweck C. Functional analysis of the aureothin iterative type I polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 6: 908-12. PMID 15812854 DOI: 10.1002/Cbic.200400333  0.387
2005 Ziehl M, He J, Dahse HM, Hertweck C. Mutasynthesis of aureonitrile: an aureothin derivative with significantly improved cytostatic effect. Angewandte Chemie (International Ed. in English). 44: 1202-5. PMID 15645471 DOI: 10.1002/Anie.200461990  0.329
2005 Winkler R, Hertweck C. Sequenzielle enzymatische Oxidation von Aminoarenen zu Nitroarenen über Hydroxylamine Angewandte Chemie. 117: 4152-4155. DOI: 10.1002/Ange.200500365  0.436
2005 Ziehl M, He J, Dahse H, Hertweck C. Mutasynthese von Aureonitril, einem Aureothin‐Derivat mit signifikant verbesserter zytostatischer Aktivität Angewandte Chemie. 117: 1226-1230. DOI: 10.1002/Ange.200461990  0.306
2004 He J, Müller M, Hertweck C. Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase. Journal of the American Chemical Society. 126: 16742-3. PMID 15612710 DOI: 10.1021/Ja046104H  0.406
2004 Herold K, Xu Z, Gollmick FA, Grafe U, Hertweck C. Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety. Organic & Biomolecular Chemistry. 2: 2411-4. PMID 15326518 DOI: 10.1039/B409221J  0.335
2004 Hertweck C, Xiang L, Kalaitzis JA, Cheng Q, Palzer M, Moore BS. Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction. Chemistry & Biology. 11: 461-8. PMID 15123240 DOI: 10.1016/J.Chembiol.2004.03.018  0.698
2004 He J, Hertweck C. Biosynthetic origin of the rare nitroaryl moiety of the polyketide antibiotic aureothin: involvement of an unprecedented N-oxygenase. Journal of the American Chemical Society. 126: 3694-5. PMID 15038705 DOI: 10.1021/Ja039328T  0.416
2004 Jakobi K, Hertweck C. A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns. Journal of the American Chemical Society. 126: 2298-9. PMID 14982421 DOI: 10.1021/Ja0390698  0.37
2003 He J, Hertweck C. Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster. Chemistry & Biology. 10: 1225-32. PMID 14700630 DOI: 10.1016/J.Chembiol.2003.11.009  0.46
2003 Kalaitzis JA, Izumikawa M, Xiang L, Hertweck C, Moore BS. Mutasynthesis of enterocin and wailupemycin analogues. Journal of the American Chemical Society. 125: 9290-1. PMID 12889947 DOI: 10.1021/Ja035973O  0.662
2002 Moore BS, Hertweck C, Hopke JN, Izumikawa M, Kalaitzis JA, Nilsen G, O'Hare T, Piel J, Shipley PR, Xiang L, Austin MB, Noel JP. Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. Journal of Natural Products. 65: 1956-62. PMID 12502351 DOI: 10.1021/Np020230M  0.729
2002 Moore BS, Hertweck C. Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Natural Product Reports. 19: 70-99. PMID 11902441 DOI: 10.1039/B003939J  0.633
2001 Hertweck C, Jarvis AP, Xiang L, Moore BS, Oldham NJ. A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation. Chembiochem : a European Journal of Chemical Biology. 2: 784-6. PMID 11948863 DOI: 10.1002/1439-7633(20011001)2:10<784::Aid-Cbic784>3.0.Co;2-K  0.579
2001 Maier I, Hertweck C, Boland W. Stereochemical specificity of lamoxirene, the sperm-releasing pheromone in kelp (Laminariales, Phaeophyceae). The Biological Bulletin. 201: 121-5. PMID 11687384 DOI: 10.2307/1543327  0.348
2000 Piel J, Hertweck C, Shipley PR, Hunt DM, Newman MS, Moore BS. Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. Chemistry & Biology. 7: 943-55. PMID 11137817 DOI: 10.1016/S1074-5521(00)00044-2  0.735
2000 Hertweck C, Boland W. Tandem reduction-chloroallylboration of esters: asymmetric synthesis of lamoxirene, the spermatozoid releasing and attracting pheromone of the laminariales (Phaeophyceae). The Journal of Organic Chemistry. 65: 2458-63. PMID 10789457 DOI: 10.1021/Jo991629R  0.37
2000 Hertweck C, Moore BS. A Plant-like Biosynthesis of Benzoyl-CoA in the Marine Bacterium ‘Streptomyces maritimus’ Tetrahedron. 56: 9115-9120. DOI: 10.1016/S0040-4020(00)00765-1  0.642
1997 Hertweck C, Boland W. Porcine pancreatic lipase (PPL) - a versatile biocatalyst in organic synthesis Journal FüR Praktische Chemie/Chemiker-Zeitung. 339: 200-202. DOI: 10.1002/Prac.19973390138  0.355
1997 Hertweck C, Boland W. Horse liver alcohol dehydrogenase (HLADH); biocatalytic redox-transformations in organic synthesis Journal FüR Praktische Chemie/Chemiker-Zeitung. 339: 754-757. DOI: 10.1002/Prac.199733901137  0.333
Low-probability matches (unlikely to be authored by this person)
2017 Marion A, Groll M, Scharf DH, Scherlach K, Glaser M, Sievers H, Schuster M, Hertweck C, Brakhage AA, Antes I, Huber EM. Gliotoxin biosynthesis: Structure, mechanism and metal promiscuity of carboxypeptidase GliJ. Acs Chemical Biology. PMID 28525266 DOI: 10.1021/Acschembio.6B00847  0.298
2018 Fischer J, Müller SY, Netzker T, Jäger N, Gacek-Matthews A, Scherlach K, Stroe MC, García-Altares M, Pezzini F, Schoeler H, Reichelt M, Gershenzon J, Krespach MK, Shelest E, Schroeckh V, ... ... Hertweck C, et al. Author response: Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites Elife. DOI: 10.7554/Elife.40969.035  0.297
2006 Kniemeyer O, Lessing F, Scheibner O, Hertweck C, Brakhage AA. Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus. Current Genetics. 49: 178-89. PMID 16362819 DOI: 10.1007/S00294-005-0047-9  0.297
2009 Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C. Polyketide-chain branching by an enzymatic Michael addition. Angewandte Chemie (International Ed. in English). 48: 5001-4. PMID 19266509 DOI: 10.1002/Anie.200900277  0.295
2023 Herisse M, Ishida K, Staiger-Creed J, Judd L, Williams SJ, Howden BP, Stinear TP, Dahse HM, Voigt K, Hertweck C, Pidot SJ. Discovery and Biosynthesis of the Cytotoxic Polyene Terpenomycin in Human Pathogenic . Acs Chemical Biology. PMID 37498707 DOI: 10.1021/acschembio.3c00311  0.295
2022 Büttner H, Pidot SJ, Scherlach K, Hertweck C. Endofungal bacteria boost anthelminthic host protection with the biosurfactant symbiosin. Chemical Science. 14: 103-112. PMID 36605741 DOI: 10.1039/d2sc04167g  0.292
2019 Blei F, Dörner S, Fricke J, Baldeweg F, Trottmann F, Komor A, Meyer F, Hertweck C, Hoffmeister D. Simultaneous Production of Psilocybin and a Cocktail of β-Carboline Monoamine Oxidase Inhibitors in 'Magic' Mushrooms. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31729089 DOI: 10.1002/Chem.201904363  0.292
2016 Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. Our Advisors, Our Ambassadors, Our Editorial Board Members. Cell Chemical Biology. 23: 311-2. PMID 26991096 DOI: 10.1016/J.Chembiol.2016.03.004  0.292
2006 Wangun HV, Härtl A, Tam Kiet T, Hertweck C. Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors. Organic & Biomolecular Chemistry. 4: 2545-8. PMID 16791316 DOI: 10.1039/B604505G  0.289
2008 Ziemert N, Ishida K, Liaimer A, Hertweck C, Dittmann E. Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria Angewandte Chemie - International Edition. 47: 7756-7759. PMID 18683268 DOI: 10.1002/Anie.200802730  0.287
2019 Molloy EM, Dell M, Hertweck C. Discovery of Amidotemplated Natural Product Assembly. Biochemistry. 58: 4583-4584. PMID 31710464 DOI: 10.1021/Acs.Biochem.9B00928  0.285
2016 De Felice A, Silipo A, Scherlach K, Ross C, Hertweck C, Molinaro A. Structural and Conformational Study of the O-Antigenic Portion of the Lipopolysaccharide Isolated from Burkholderia gladioli pv. cocovenenans European Journal of Organic Chemistry. DOI: 10.1002/Ejoc.201501308  0.284
2023 Büttner H, Hörl J, Krabbe J, Hertweck C. Discovery and Biosynthesis of Anthrochelin, a Growth-Promoting Metallophore of the Human Pathogen Luteibacter anthropi. Chembiochem : a European Journal of Chemical Biology. e202300322. PMID 37191164 DOI: 10.1002/cbic.202300322  0.284
2005 Gebhardt P, Gräfe U, Möllmann U, Hertweck C. Semisynthetic preparation of leucomycin derivatives: Introduction of aromatic side chains by reductive amination Molecular Diversity. 9: 27-32. PMID 15789548 DOI: 10.1007/S11030-005-1304-Z  0.283
2014 Mohan S, Hertweck C, Dudda A, Hammerschmidt S, Skerka C, Hallström T, Zipfel PF. Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein. Molecular Immunology. 62: 249-64. PMID 25046156 DOI: 10.1016/J.Molimm.2014.06.029  0.282
2006 Kemami Wangun HV, Dörfelt H, Hertweck C. Nebularic Acids and Nebularilactones, Novel Drimane Sesquiterpenoids from the FungusLepista nebularis European Journal of Organic Chemistry. 2006: 1643-1646. DOI: 10.1002/Ejoc.200500869  0.282
2010 Rohm B, Scherlach K, Hertweck C. Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli Organic and Biomolecular Chemistry. 8: 1520-1522. PMID 20237660 DOI: 10.1039/B925483H  0.281
2021 Büttner H, Niehs SP, Vandelannoote K, Cseresnyés Z, Dose B, Richter I, Gerst R, Figge MT, Stinear TP, Pidot SJ, Hertweck C. Bacterial endosymbionts protect beneficial soil fungus from nematode attack. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34504005 DOI: 10.1073/pnas.2110669118  0.281
2009 Osada H, Hertweck C. Exploring the chemical space of microbial natural products Current Opinion in Chemical Biology. 13: 133-134. PMID 19362878 DOI: 10.1016/J.Cbpa.2009.03.017  0.28
2012 Busch B, Ueberschaar N, Sugimoto Y, Hertweck C. Interchenar retrotransfer of aureothin intermediates in an iterative polyketide synthase module. Journal of the American Chemical Society. 134: 12382-5. PMID 22799266 DOI: 10.1021/Ja304454R  0.28
2020 Neuwirth T, Letzel AC, Tank C, Ishida K, Cyrulies M, Schmölz L, Lorkowski S, Hertweck C. Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32996646 DOI: 10.1002/chem.202003500  0.278
2020 Dose B, Ross C, Niehs SP, Scherlach K, Bauer JP, Hertweck C. Food-Poisoning Bacteria Employ a Citrate Synthase and a Type II NRPS to Synthesize Bolaamphiphilic Lipopeptide Antibiotics. Angewandte Chemie (International Ed. in English). PMID 32780428 DOI: 10.1002/anie.202009107  0.276
2022 Bredy F, Ishida K, Hertweck C. A Type III Polyketide Synthase Specific for Sporulating Negativicutes is Responsible for Alkylpyrone Biosynthesis. Chembiochem : a European Journal of Chemical Biology. PMID 35997218 DOI: 10.1002/cbic.202200431  0.273
2011 Kusebauch B, Brendel N, Kirchner H, Dahse HM, Hertweck C. Assessing oxazole bioisosteres as mutasynthons on the rhizoxin assembly line. Chembiochem : a European Journal of Chemical Biology. 12: 2284-8. PMID 23106078 DOI: 10.1002/Cbic.201100387  0.273
2005 Zöllner T, Gebhardt P, Beckert R, Hertweck C. Efficient synthesis of 9- and 13-oxo leucomycin derivatives using hypervalent iodine reagents in solution and on solid support. Journal of Natural Products. 68: 112-4. PMID 15679331 DOI: 10.1021/Np049728+  0.272
2012 Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C. Titelbild: Epidithiol Formation by an Unprecedented Twin Carbon–Sulfur Lyase in the Gliotoxin Pathway (Angew. Chem. 40/2012) Angewandte Chemie. 124: 10083-10083. DOI: 10.1002/Ange.201206982  0.271
2009 Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C. Titelbild: Polyketide‐Chain Branching by an Enzymatic Michael Addition (Angew. Chem. 27/2009) Angewandte Chemie. 121: 4965-4965. DOI: 10.1002/Ange.200990140  0.27
2013 Ueberschaar N, Dahse HM, Bretschneider T, Hertweck C. Rational design of an apoptosis-inducing photoreactive DNA intercalator. Angewandte Chemie (International Ed. in English). 52: 6185-9. PMID 23649559 DOI: 10.1002/Anie.201302439  0.27
2022 Kim HJ, Ishida K, Hertweck C. Thiotemplated Biosynthesis of Bacterial Polyyne Fatty Acids by a Designated Desaturase Triad. Chembiochem : a European Journal of Chemical Biology. PMID 36107027 DOI: 10.1002/cbic.202200430  0.27
2002 Kaulmann U, Hertweck C. Biosynthese von mehrfach ungesättigten Fettsäuren durch Polyketid-Synthasen Angewandte Chemie. 114: 1947. DOI: 10.1002/1521-3757(20020603)114:11<1947::Aid-Ange1947>3.0.Co;2-1  0.269
2021 Herkersdorf S, Krüger T, Wein P, Löffler S, Fontaine T, Gressler M, Hertweck C, Brakhage AA, Hoffmeister D. Bacterial cell wall-degrading enzymes induce basidiomycete natural product biosynthesis. Environmental Microbiology. PMID 34081381 DOI: 10.1111/1462-2920.15621  0.267
2015 Leonhardt I, Spielberg S, Weber M, Albrecht-Eckardt D, Bläss M, Claus R, Barz D, Scherlach K, Hertweck C, Löffler J, Hünniger K, Kurzai O. The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. Mbio. 6: e00143. PMID 25784697 DOI: 10.1128/Mbio.00143-15  0.266
2008 Ziemert N, Ishida K, Liaimer A, Hertweck C, Dittmann E. Innentitelbild: Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom‐Forming Cyanobacteria (Angew. Chem. 40/2008) Angewandte Chemie. 120: 7678-7678. DOI: 10.1002/Ange.200890250  0.266
2009 Salnikov ES, Friedrich H, Li X, Bertani P, Reissmann S, Hertweck C, O'Neil JD, Raap J, Bechinger B. Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy. Biophysical Journal. 96: 86-100. PMID 18835909 DOI: 10.1529/Biophysj.108.136242  0.266
2015 Sundaram S, Heine D, Hertweck C. Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching. Nature Chemical Biology. 11: 949-951. PMID 26479442 DOI: 10.1038/Nchembio.1932  0.262
2012 Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C. Cover Picture: Epidithiol Formation by an Unprecedented Twin Carbon–Sulfur Lyase in the Gliotoxin Pathway (Angew. Chem. Int. Ed. 40/2012) Angewandte Chemie. 51: 9943-9943. DOI: 10.1002/Anie.201206982  0.26
2006 Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Natural Product Reports. 24: 162-90. PMID 17268612 DOI: 10.1039/B507395M  0.259
2011 Scherlach K, Sarkar A, Schroeckh V, Dahse HM, Roth M, Brakhage AA, Horn U, Hertweck C. Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones. Chembiochem : a European Journal of Chemical Biology. 12: 1836-9. PMID 21698737 DOI: 10.1002/Cbic.201100132  0.259
2009 Salnikov E, Friedrich H, Li X, Bertani P, Reissman S, Hertweck C, O'Neil J, Ovchinnikova T, Dzuba S, Rapp J, Bechinger B. Structure And Alignment Of Membrane-associated Peptaibols By Oriented 15N And 31P Solid-state NMR Spectroscopy Biophysical Journal. 96: 408a. DOI: 10.1016/J.Bpj.2008.12.2080  0.258
2023 Klapper M, Hübner A, Ibrahim A, Wasmuth I, Borry M, Haensch VG, Zhang S, Al-Jammal WK, Suma H, Fellows Yates JA, Frangenberg J, Velsko IM, Chowdhury S, Herbst R, Bratovanov EV, ... ... Hertweck C, et al. Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic. Science (New York, N.Y.). eadf5300. PMID 37141315 DOI: 10.1126/science.adf5300  0.258
2007 Gebhardt P, Dornberger K, Gollmick FA, Gräfe U, Härtl A, Görls H, Schlegel B, Hertweck C. Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill) Bioorganic and Medicinal Chemistry Letters. 17: 2558-2560. PMID 17346963 DOI: 10.1016/J.Bmcl.2007.02.008  0.257
2008 Ziemert N, Ishida K, Liaimer A, Hertweck C, Dittmann E. Inside Cover: Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom‐Forming Cyanobacteria (Angew. Chem. Int. Ed. 40/2008) Angewandte Chemie. 47: 7566-7566. DOI: 10.1002/Anie.200890196  0.257
2010 Krügel H, Licht A, Biedermann G, Petzold A, Lassak J, Hupfer Y, Schlott B, Hertweck C, Platzer M, Brantl S, Saluz HP. Cervimycin C resistance in Bacillus subtilis is due to a promoter up-mutation and increased mRNA stability of the constitutive ABC-transporter gene bmrA. Fems Microbiology Letters. 313: 155-63. PMID 21077936 DOI: 10.1111/J.1574-6968.2010.02143.X  0.257
2013 Coyne S, Chizzali C, Khalil MNA, Litomska A, Richter K, Beerhues L, Hertweck C. Titelbild: Biosynthesis of the Antimetabolite 6-Thioguanine inErwinia amylovoraPlays a Key Role in Fire Blight Pathogenesis (Angew. Chem. 40/2013) Angewandte Chemie. 125: 10583-10583. DOI: 10.1002/Ange.201307309  0.257
2012 Henrot M, Richter MEA, Maddaluno J, Hertweck C, De Paolis M. Titelbild: Convergent Asymmetric Synthesis of (+)-Aureothin Employing an Oxygenase-Mediated Resolution Step (Angew. Chem. 38/2012) Angewandte Chemie. 124: 9593-9593. DOI: 10.1002/Ange.201206228  0.253
2022 Richter I, Radosa S, Cseresnyés Z, Ferling I, Büttner H, Niehs SP, Gerst R, Scherlach K, Figge MT, Hillmann F, Hertweck C. Toxin-Producing Endosymbionts Shield Pathogenic Fungus against Micropredators. Mbio. e0144022. PMID 36005392 DOI: 10.1128/mbio.01440-22  0.251
2012 Henrot M, Richter ME, Maddaluno J, Hertweck C, De Paolis M. Convergent asymmetric synthesis of (+)-aureothin employing an oxygenase-mediated resolution step. Angewandte Chemie (International Ed. in English). 51: 9587-91. PMID 22807210 DOI: 10.1002/Anie.201204259  0.251
2012 Henrot M, Richter MEA, Maddaluno J, Hertweck C, De Paolis M. Cover Picture: Convergent Asymmetric Synthesis of (+)-Aureothin Employing an Oxygenase-Mediated Resolution Step (Angew. Chem. Int. Ed. 38/2012) Angewandte Chemie International Edition. 51: 9455-9455. DOI: 10.1002/Anie.201206228  0.249
2016 Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. From Powerful Review Articles to Research Breakthroughs. Cell Chemical Biology. 23: 883-4. PMID 27541190 DOI: 10.1016/J.Chembiol.2016.08.002  0.248
2015 Gressler M, Meyer F, Heine D, Hortschansky P, Hertweck C, Brock M. Author response: Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals Elife. DOI: 10.7554/Elife.07861.034  0.247
2014 Scharf DH, Groll M, Habel A, Heinekamp T, Hertweck C, Brakhage AA, Huber EM. Flavoenzym‐katalysierte Bildung von Disulfidbrücken in Naturstoffen Angewandte Chemie. 126: 2253-2256. DOI: 10.1002/Ange.201309302  0.246
2013 Coyne S, Chizzali C, Khalil MNA, Litomska A, Richter K, Beerhues L, Hertweck C. Cover Picture: Biosynthesis of the Antimetabolite 6-Thioguanine inErwinia amylovoraPlays a Key Role in Fire Blight Pathogenesis (Angew. Chem. Int. Ed. 40/2013) Angewandte Chemie International Edition. 52: 10391-10391. DOI: 10.1002/Anie.201307309  0.246
2016 Ueberschaar N, Meyer F, Dahse HM, Hertweck C. Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides. Chemical Communications (Cambridge, England). PMID 26974406 DOI: 10.1039/C6Cc00890A  0.244
2021 Mahler L, Niehs SP, Martin K, Weber T, Scherlach K, Hertweck C, Roth M, Rosenbaum MA. Highly parallelized droplet cultivation and prioritization on antibiotic producers from natural microbial communities. Elife. 10. PMID 33764297 DOI: 10.7554/eLife.64774  0.244
2023 Schäfer E, Seibold PS, Bartram S, Trottmann F, Hänsch V, Gressler M, Chadeayne A, Hertweck C, O'Connor S, Hoffmeister D. A "Magic Mushroom" Multi-Product Sesquiterpene Synthase. Chembiochem : a European Journal of Chemical Biology. e202300511. PMID 37614035 DOI: 10.1002/cbic.202300511  0.243
2023 Trottmann F, Fiedler J, Ishida K, Ishida-Ito M, Little RF, Hertweck C. Bacterial Pathogen Channels Medium-Sized Fatty Acids into Malleicyprol Biosynthesis. Acs Chemical Biology. 18: 1557-1563. PMID 37319349 DOI: 10.1021/acschembio.3c00188  0.242
2012 Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C. Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angewandte Chemie (International Ed. in English). 51: 10064-8. PMID 22936680 DOI: 10.1002/Anie.201205041  0.241
2016 Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. Voices of Chemical Biology: Charting the Next Decade. Cell Chemical Biology. 23: 199. PMID 26971865 DOI: 10.1016/J.Chembiol.2016.02.006  0.241
2021 Scherlach K, Hertweck C. Mining and unearthing hidden biosynthetic potential. Nature Communications. 12: 3864. PMID 34162873 DOI: 10.1038/s41467-021-24133-5  0.24
2011 Kusebauch B, Scherlach K, Kirchner H, Dahse HM, Hertweck C. Antiproliferative effects of ester- and amide-functionalized rhizoxin derivatives. Chemmedchem. 6: 1998-2001. PMID 21990089 DOI: 10.1002/Cmdc.201100319  0.239
2014 Heine D, Bretschneider T, Sundaram S, Hertweck C. Enzymatische Polyketid-Kettenverzweigung zur Bildung substituierter Lacton-, Lactam- und Glutarimidheterocyclen† Angewandte Chemie. 126: 11829-11833. DOI: 10.1002/Ange.201407282  0.239
2014 Weiz AR, Ishida K, Quitterer F, Meyer S, Kehr J, Müller KM, Groll M, Hertweck C, Dittmann E. Analyse von Protease‐Inhibitor‐Interaktionen unter Nutzung evolvierbarer tricyclischer Microviridine Angewandte Chemie. 126: 3810-3813. DOI: 10.1002/Ange.201309721  0.237
2017 Brandt P, García-Altares M, Nett M, Hertweck C, Hoffmeister D. Induzierte chemische Verteidigung eines Ständerpilzes durch eine doppelbindungsverschiebende Polyensynthase Angewandte Chemie. 129: 6031-6035. DOI: 10.1002/Ange.201700767  0.237
2019 Kramell AE, García-Altares M, Pötsch M, Kluge R, Rother A, Hause G, Hertweck C, Csuk R. Mapping Natural Dyes in Archeological Textiles by Imaging Mass Spectrometry. Scientific Reports. 9: 2331. PMID 30787311 DOI: 10.1038/S41598-019-38706-4  0.235
2023 Richter I, Uzum Z, Wein P, Molloy EM, Moebius N, Stinear TP, Pidot SJ, Hertweck C. Transcription activator-like effectors from endosymbiotic bacteria control the reproduction of their fungal host. Mbio. 14: e0182423. PMID 37971247 DOI: 10.1128/mbio.01824-23  0.235
2008 Richter MEA, Traitcheva N, Knüpfer U, Hertweck C. Sequential asymmetric polyketide heterocyclization catalyzed by a single cytochrome p450 monooxygenase (AurH) Angewandte Chemie - International Edition. 47: 8872-8875. PMID 18855960 DOI: 10.1002/Anie.200803714  0.235
2021 Molloy EM, Dell M, Haensch VG, Dunbar KL, Feldmann R, Oberheide A, Seyfarth L, Kumpfmüller J, Horch T, Arndt HD, Hertweck C. Enzyme-Primed Native Chemical Ligation Produces Autoinducing Cyclopeptides in Clostridia. Angewandte Chemie (International Ed. in English). PMID 33625794 DOI: 10.1002/anie.202016378  0.234
2009 Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C. Cover Picture: Polyketide-Chain Branching by an Enzymatic Michael Addition (Angew. Chem. Int. Ed. 27/2009) Angewandte Chemie International Edition. 48: 4869-4869. DOI: 10.1002/Anie.200990138  0.233
2013 Boettger D, Hertweck C. Molecular diversity sculpted by fungal PKS-NRPS hybrids. Chembiochem : a European Journal of Chemical Biology. 14: 28-42. PMID 23225733 DOI: 10.1002/cbic.201200624  0.233
2005 Herold K, Gollmick FA, Groth I, Roth M, Menzel K, Möllmann U, Gräfe U, Hertweck C. Cover Picture: Cervimycin A-D: A Polyketide Glycoside Complex from a Cave Bacterium Can Defeat Vancomycin Resistance (Chem. Eur. J. 19/2005) Chemistry - a European Journal. 11: 5475-5475. DOI: 10.1002/Chem.200590060  0.232
2017 Doménech-Carbó A, Cebrían-Torrejón G, Montoya N, Ueberschaar N, Scotti MT, Benfodda Z, Hertweck C. Electrochemical monitoring of ROS generation by anticancer agents: the case of chartreusin Rsc Advances. 7: 45200-45210. DOI: 10.1039/C7Ra08238J  0.229
2016 Granada S, Bedoya-Pérez J, Scherlach K, Hertweck C. Serratia marcescens metabolites are promising candidates for biocontrol of avocado pathogens Planta Medica. 81: S1-S381. DOI: 10.1055/s-0036-1596657  0.229
2009 Hertweck C. Die biosynthetische Grundlage der Polyketid‐Vielfalt Angewandte Chemie. 121: 4782-4811. DOI: 10.1002/Ange.200806121  0.228
2023 Wein P, Dornblut K, Herkersdorf S, Krüger T, Molloy EM, Brakhage AA, Hoffmeister D, Hertweck C. Bacterial secretion systems contribute to rapid tissue decay in button mushroom soft rot disease. Mbio. e0078723. PMID 37486262 DOI: 10.1128/mbio.00787-23  0.227
2020 Dunbar KL, Dell M, Molloy EM, Büttner H, Kumpfmüller J, Hertweck C. An Unexpected Split-Merge Pathway to the Symmetric Nonribosomal Peptide Antibiotic Closthioamide. Angewandte Chemie (International Ed. in English). PMID 33119936 DOI: 10.1002/anie.202011741  0.224
2023 Krespach MKC, Stroe MC, Netzker T, Rosin M, Zehner LM, Komor AJ, Beilmann JM, Krüger T, Scherlach K, Kniemeyer O, Schroeckh V, Hertweck C, Brakhage AA. Streptomyces polyketides mediate bacteria-fungi interactions across soil environments. Nature Microbiology. 8: 1348-1361. PMID 37322111 DOI: 10.1038/s41564-023-01382-2  0.224
2014 Crews C, Hertweck C, Shokat K, Suga H, Kostic M. Reflecting on the past and looking forward to the future of bridging chemistry and biology. Chemistry & Biology. 21: 1035-6. PMID 25237850 DOI: 10.1016/J.Chembiol.2014.09.004  0.224
2001 Hertweck C, Šebek P, Svatoš A. A highly efficient and versatile synthesis of D- and L-erythro-sphinganine Synlett. 2001: 1965-1967. DOI: 10.1055/S-2001-18784  0.22
2021 Scherlach K, Kuttenlochner W, Scharf DH, Brakhage AA, Hertweck C, Groll M, Huber E. Structural and mechanistic insights into C-S bond formation in gliotoxin. Angewandte Chemie (International Ed. in English). PMID 33909314 DOI: 10.1002/anie.202104372  0.22
2023 Rassbach J, Hilsberg N, Haensch VG, Dörner S, Gressler J, Sonnabend R, Semm C, Voigt K, Hertweck C, Gressler M. Non-canonical two-step biosynthesis of anti-oomycete indole alkaloids in Kickxellales. Fungal Biology and Biotechnology. 10: 19. PMID 37670394 DOI: 10.1186/s40694-023-00166-x  0.217
2023 Richter I, Wein P, Uzum Z, Stanley CE, Krabbe J, Molloy EM, Moebius N, Ferling I, Hillmann F, Hertweck C. Transcription activator-like effector protects bacterial endosymbionts from entrapment within fungal hyphae. Current Biology : Cb. PMID 37301202 DOI: 10.1016/j.cub.2023.05.028  0.217
2006 Müller M, Kusebauch B, Liang G, Beaudry CM, Trauner D, Hertweck C. Photochemical origin of the immunosuppressive SNF4435C/D and formation of orinocin through "polyene splicing". Angewandte Chemie (International Ed. in English). 45: 7835-8. PMID 17066387 DOI: 10.1002/Anie.200602840  0.215
2018 Mahler L, Wink K, Beulig RJ, Scherlach K, Tovar M, Zang E, Martin K, Hertweck C, Belder D, Roth M. Publisher Correction: Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria. Scientific Reports. 8: 15859. PMID 30353032 DOI: 10.1038/S41598-018-34069-4  0.214
2009 Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C. Functionally Distinct Modules Operate Two Consecutive α,β→β,γ Double-Bond Shifts in the Rhizoxin Polyketide Assembly Line Angewandte Chemie. 122: 1502-1506. DOI: 10.1002/Ange.200905467  0.211
2022 Pourmasoumi F, De S, Peng H, Trottmann F, Hertweck C, Kries H. Proof-Reading Thioesterase Boosts Activity of Engineered Nonribosomal Peptide Synthetase. Acs Chemical Biology. 17: 2382-2388. PMID 36044980 DOI: 10.1021/acschembio.2c00341  0.21
2015 Baunach M, Hertweck C. Natural 1,3-Dipolar Cycloadditions. Angewandte Chemie (International Ed. in English). 54: 12550-2. PMID 26465651 DOI: 10.1002/anie.201507120  0.209
2022 Janke RS, Kaftan F, Niehs SP, Scherlach K, Rodrigues A, Svatoš A, Hertweck C, Kaltenpoth M, Flórez LV. Bacterial ectosymbionts in cuticular organs chemically protect a beetle during molting stages. The Isme Journal. PMID 36056153 DOI: 10.1038/s41396-022-01311-x  0.205
2011 Hertweck C. Biosynthese und Einbau von Pyrrolysin, der 22. genetisch codierten Aminosäure Angewandte Chemie. 123: 9712-9714. DOI: 10.1002/Ange.201103769  0.2
2022 Morales-Amador A, Souto ML, Hertweck C, Fernández JJ, García-Altares M. Rapid Screening of Polyol Polyketides from Marine Dinoflagellates. Analytical Chemistry. PMID 36190828 DOI: 10.1021/acs.analchem.2c02185  0.2
2005 Wangun HV, Berg A, Hertel W, Nkengfack AE, Hertweck C. Anti-inflammatory and anti-hyaluronate lyase activities of lanostanoids from Piptoporus betulinus. The Journal of Antibiotics. 57: 755-8. PMID 15712671 DOI: 10.7164/Antibiotics.57.755  0.199
2021 Little RF, Hertweck C. Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis. Natural Product Reports. PMID 34622896 DOI: 10.1039/d1np00035g  0.197
2009 Tchize Ndejouong BLS, Sattler I, Dahse HM, Kothe E, Hertweck C. Isoflavones with unusually modified B-rings and their evaluation as antiproliferative agents Bioorganic and Medicinal Chemistry Letters. 19: 6473-6476. PMID 19818612 DOI: 10.1016/j.bmcl.2009.08.084  0.196
2010 Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C. Functionally distinct modules operate two consecutive alpha,beta-->beta,gamma double-bond shifts in the rhizoxin polyketide assembly line. Angewandte Chemie (International Ed. in English). 49: 1460-4. PMID 20033973 DOI: 10.1002/Anie.200905467  0.196
2022 Kim HJ, Ishida K, Ishida-Ito M, Hertweck C. Sequential Allylic Alcohol Formation by a Multifunctional Cytochrome P450 Monooxygenase with Rare Redox Partners. Angewandte Chemie (International Ed. in English). PMID 35416382 DOI: 10.1002/anie.202203264  0.194
2020 Senges CHR, Stepanek JJ, Wenzel M, Raatschen N, Ay Ü, Märtens Y, Prochnow P, Vázquez Hernández M, Yayci A, Schubert B, Janzing NBM, Warmuth HL, Kozik M, Bongard J, Alumasa JN, ... ... Hertweck C, et al. Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation. Antimicrobial Agents and Chemotherapy. PMID 33046497 DOI: 10.1128/AAC.01373-20  0.193
2022 Gude F, Molloy EM, Horch T, Dell M, Dunbar KL, Krabbe J, Groll M, Hertweck C. A Specialized Polythioamide-Binding Protein Confers Antibiotic Self-Resistance in Anaerobic Bacteria. Angewandte Chemie (International Ed. in English). e202206168. PMID 35852818 DOI: 10.1002/anie.202206168  0.185
2013 Ueberschaar N, Dahse H, Bretschneider T, Hertweck C. Inside Cover: Rational Design of an Apoptosis‐Inducing Photoreactive DNA Intercalator (Angew. Chem. Int. Ed. 24/2013) Angewandte Chemie. 52: 6114-6114. DOI: 10.1002/Anie.201303645  0.185
2023 Kries H, Trottmann F, Hertweck C. Novel Biocatalysts from Specialized Metabolism. Angewandte Chemie (International Ed. in English). 63: e202309284. PMID 37737720 DOI: 10.1002/anie.202309284  0.183
2006 Müller M, Kusebauch B, Liang G, Beaudry CM, Trauner D, Hertweck C. Photochemische Herkunft der Immunsuppressiva SNF4435C/D und Bildung von Orinocin durch “Polyen-Splicing” Angewandte Chemie. 118: 7999-8002. DOI: 10.1002/Ange.200602840  0.182
2022 Dietrich A, Steffens U, Gajdiss M, Boschert AL, Dröge JK, Szekat C, Sass P, Malik IT, Bornikoel J, Reinke L, Maček B, Franz-Wachtel M, Nieselt K, Harbig T, Scherlach K, ... ... Hertweck C, et al. Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes. Microbiology Spectrum. e0256722. PMID 36173303 DOI: 10.1128/spectrum.02567-22  0.181
2013 Ueberschaar N, Dahse H, Bretschneider T, Hertweck C. Innentitelbild: Rational Design of an Apoptosis‐Inducing Photoreactive DNA Intercalator (Angew. Chem. 24/2013) Angewandte Chemie. 125: 6239-6239. DOI: 10.1002/Ange.201303645  0.18
2015 Hertweck C. Naturstoffe als Quelle für Therapeutika gegen parasitäre Krankheiten Angewandte Chemie. 127: 14830-14832. DOI: 10.1002/Ange.201509828  0.175
2022 Kuang Y, Scherlach K, Hertweck C, Yang S, Sampietro DA, Karlovsky P. Fusaric acid detoxification: a strategy of Gliocladium roseum involved in its antagonism against Fusarium verticillioides. Mycotoxin Research. PMID 35023019 DOI: 10.1007/s12550-021-00448-6  0.174
2015 Baunach M, Hertweck C. Natürliche 1,3-dipolare Cycloadditionen Angewandte Chemie. 127: 12732-12734. DOI: 10.1002/Ange.201507120  0.174
2022 Stallforth P, Mittag M, Brakhage AA, Hertweck C, Hellmich UA. Functional modulation of chemical mediators in microbial communities. Trends in Biochemical Sciences. PMID 35981931 DOI: 10.1016/j.tibs.2022.07.006  0.172
2010 Tchize Ndejouong BLS, Sattler I, Maier A, Kelter G, Menzel KD, Fiebig HH, Hertweck C. Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis Journal of Antibiotics. 63: 359-363. PMID 20551984 DOI: 10.1038/ja.2010.52  0.17
2022 Haensch VG, Görls H, Hertweck C. A Photochemical Macrocyclization Route to Asymmetric Strained [3.2]Paracyclophanes. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 36094023 DOI: 10.1002/chem.202202577  0.169
2022 Little R, Trottmann F, Preissler M, Hertweck C. An intramodular thioesterase domain catalyses chain release in the biosynthesis of a cytotoxic virulence factor. Rsc Chemical Biology. 3: 1121-1128. PMID 36128506 DOI: 10.1039/d2cb00121g  0.168
2021 Dell M, Dunbar KL, Hertweck C. Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature. Natural Product Reports. PMID 34586117 DOI: 10.1039/d1np00019e  0.16
2015 Horn F, Üzüm Z, Möbius N, Guthke R, Linde J, Hertweck C. Draft Genome Sequences of Symbiotic and Nonsymbiotic Rhizopus microsporus Strains CBS 344.29 and ATCC 62417. Genome Announcements. 3. PMID 25614557 DOI: 10.1128/genomeA.01370-14  0.159
2014 Sun Y, Chen P, Zhang D, Baunach M, Hertweck C, Li A. Bioinspired total synthesis of sespenine. Angewandte Chemie (International Ed. in English). 53: 9012-6. PMID 24962149 DOI: 10.1002/Anie.201404191  0.157
2015 Hertweck C. Natural Products as Source of Therapeutics against Parasitic Diseases. Angewandte Chemie (International Ed. in English). PMID 26546400 DOI: 10.1002/anie.201509828  0.157
2023 Weber JN, Minner-Meinen R, Behnecke M, Biedendieck R, Hänsch VG, Hercher TW, Hertweck C, van den Hout L, Knüppel L, Sivov S, Schulze J, Mendel RR, Hänsch R, Kaufholdt D. Moonlighting Arabidopsis molybdate transporter 2 family and GSH-complex formation facilitate molybdenum homeostasis. Communications Biology. 6: 801. PMID 37532778 DOI: 10.1038/s42003-023-05161-x  0.15
2023 Dell M, Tran MA, Capper MJ, Sundaram S, Fiedler J, Koehnke J, Hellmich UA, Hertweck C. Trapping of a Polyketide Synthase Module After C-C Bond Formation Reveals Transient Acyl Carrier Domain Interactions. Angewandte Chemie (International Ed. in English). e202315850. PMID 38134222 DOI: 10.1002/anie.202315850  0.146
2022 Lenz C, Dörner S, Trottmann F, Hertweck C, Sherwood A, Hoffmeister D. Assessment of Bioactivity-Modulating Pseudo-Ring Formation in Psilocin and Related Tryptamines. Chembiochem : a European Journal of Chemical Biology. PMID 35483009 DOI: 10.1002/cbic.202200183  0.138
2013 Mayeku PW, Hassanali A, Kiremire BT, Odalo JO, Hertweck C. Anti-bacterial activities and phytochemical screening of extracts of different parts of Thalictrum rhynchocarpum. African Journal of Traditional, Complementary, and Alternative Medicines : Ajtcam / African Networks On Ethnomedicines. 10: 341-4. PMID 24311847  0.13
2014 Cai X, Ng K, Panesar H, Moon SJ, Paredes M, Ishida K, Hertweck C, Minehan TG. Total synthesis of the antitumor natural product polycarcin V and evaluation of its DNA binding profile. Organic Letters. 16: 2962-5. PMID 24824354 DOI: 10.1021/ol501095w  0.13
2024 Haensch VG, Hertweck C. Photosensitizers Enable the Formation of Biphenyls with UV-LEDs and Sunlight. Chemistry (Weinheim An Der Bergstrasse, Germany). e202400605. PMID 38421111 DOI: 10.1002/chem.202400605  0.12
2024 Little RF, Trottmann F, Hashizume H, Preissler M, Unger S, Sawa R, Kries H, Pidot S, Igarashi M, Hertweck C. Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds. Acs Chemical Biology. PMID 38358369 DOI: 10.1021/acschembio.3c00648  0.12
2002 Krock B, Schmidt S, Hertweck C, Baldwin IT. Vegetation-derived abscisic acid and four terpenes enforce dormancy in seeds of the post-fire annual,Nicotiana attenuata Seed Science Research. 12: 239-252. DOI: 10.1079/Ssr2002117  0.11
2022 Klemm P, Solomun JI, Rodewald M, Kuchenbrod MT, Hänsch VG, Richter F, Popp J, Hertweck C, Hoeppener S, Bonduelle C, Lecommandoux S, Traeger A, Schubert S. Efficient Gene Delivery of Tailored Amphiphilic Polypeptides by Polyplex Surfing. Biomacromolecules. 23: 4718-4733. PMID 36269943 DOI: 10.1021/acs.biomac.2c00919  0.108
2014 Cai X, Ng K, Panesar H, Moon S, Paredes M, Ishida K, Hertweck C, Minehan TG. ChemInform Abstract: Total Synthesis of the Antitumor Natural Product Polycarcin V and Evaluation of Its DNA Binding Profile. Cheminform. 45: no-no. DOI: 10.1002/chin.201449216  0.105
2021 Little RF, Hertweck C. Correction: Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis. Natural Product Reports. PMID 34636382 DOI: 10.1039/d1np90038b  0.103
2023 Kuang Y, Scherlach K, Hertweck C, Yang S, Sampietro DA, Karlovsky P. Retraction Note: Fusaric acid detoxification: a strategy of Gliocladium roseum involved in its antagonism against Fusarium verticillioides. Mycotoxin Research. PMID 37199832 DOI: 10.1007/s12550-023-00481-7  0.097
2020 Gama S, Hermenau R, Frontauria M, Milea D, Sammartano S, Hertweck C, Plass W. Iron coordination properties of gramibactin as model for the new class of diazeniumdiolate based siderophores. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 33006390 DOI: 10.1002/chem.202003842  0.091
2008 Kemami Wangun HV, Ishida K, Hertweck C. Epicoccalone, a coumarin-type chymotrypsin inhibitor, and isobenzofuran congeners from an Epicoccum sp. associated with a tree fungus European Journal of Organic Chemistry. 3781-3784. DOI: 10.1002/ejoc.200800447  0.088
2006 Herold K, Gollmick FA, Groth I, Roth M, Menzel K, Moellmann U, Graefe U, Hertweck C. Cervimycin A—D: A Polyketide Glycoside Complex from a Cave Bacterium Can Defeat Vancomycin Resistance. Cheminform. 37. DOI: 10.1002/chin.200608200  0.086
2022 Michel M, Benítez-Buelga C, Calvo PA, Hanna BMF, Mortusewicz O, Masuyer G, Davies J, Wallner O, Sanjiv K, Albers JJ, Castañeda-Zegarra S, Jemth AS, Visnes T, Sastre-Perona A, Danda AN, ... ... Hertweck C, et al. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science (New York, N.Y.). 376: 1471-1476. PMID 35737787 DOI: 10.1126/science.abf8980  0.085
2009 Kaulmann U, Hertweck C. Biosynthesis of polyunsaturated fatty acids by polyketide synthases. Angewandte Chemie (International Ed. in English). 41: 1866-9. PMID 19750617 DOI: 10.1002/1521-3773(20020603)41:11<1866::AID-ANIE1866>3.0.CO;2-3  0.08
2011 Hertweck C. Biosynthesis and charging of pyrrolysine, the 22nd genetically encoded amino acid. Angewandte Chemie (International Ed. in English). 50: 9540-1. PMID 21796749 DOI: 10.1002/anie.201103769  0.078
2010 Scherlach K, Schuemann J, Dahse HM, Hertweck C. Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans Journal of Antibiotics. 63: 375-377. PMID 20661238 DOI: 10.1038/ja.2010.46  0.072
2010 Gomes PB, Nett M, Dahse HM, Sattler I, Martin K, Hertweck C. Bezerramycins A-C, antiproliferative phenoxazinones from streptomyces griseus featuring carboxy, carboxamide or nitrile substituents European Journal of Organic Chemistry. 231-235. DOI: 10.1002/ejoc.200901206  0.07
2008 Werneburg M, Hertweck C. Chemoenzymatic total synthesis of the antiproliferative polyketide (+)-(R)-aureothin Chembiochem. 9: 2064-2066. PMID 18690656 DOI: 10.1002/cbic.200800301  0.06
2007 Wangun HVK, Hertweck C. Squarrosidine and pinillidine: 3,3′-fused bis(styrylpyrones) from Pholiota squarrosa and Phellinus pini European Journal of Organic Chemistry. 3292-3295. DOI: 10.1002/ejoc.200700090  0.05
2010 Rohr J, Hertweck C. Type II PKS Comprehensive Natural Products Ii: Chemistry and Biology. 1: 227-303.  0.044
2015 Zocher G, Vilstrup J, Heine D, Hallab A, Goralski E, Hertweck C, Stahl M, Schäberle TF, Stehle T. Structural basis of head to head polyketide fusion by CorB Chemical Science. 6: 6525-6536. DOI: 10.1039/c5sc02488a  0.042
2022 Sharma G, Islam ST, Rahi P, Silby MW, Giovannelli D, Welander PV, Ehling-Schulz M, Chaudhry V, Molloy E, Hertweck C, Mundra S, Kalia VC, Lal R, Singh Y, Ruby E, et al. Reply to Oren et al., "New Phylum Names Harmonize Prokaryotic Nomenclature". Mbio. e0232322. PMID 36106733 DOI: 10.1128/mbio.02323-22  0.04
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