Nicole A. Horenstein, Ph.D. - Publications

Chemistry University of Florida, Gainesville, Gainesville, FL, United States 
Organic Chemistry, Enzymology, Bioorganic Chemistry

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Papke RL, Horenstein NA. Therapeutic Targeting of 7 Nicotinic Acetylcholine Receptors. Pharmacological Reviews. 73: 1118-1149. PMID 34301823 DOI: 10.1124/pharmrev.120.000097  1
2021 Pismataro MC, Horenstein NA, Stokes C, Dallanoce C, Thakur GA, Papke RL. Stable desensitization of α nicotinic acetylcholine receptors by NS6740 requires interaction with S36 in the orthosteric agonist binding site. European Journal of Pharmacology. 905: 174179. PMID 34004208 DOI: 10.1016/j.ejphar.2021.174179  1
2020 Gulsevin A, Meiler J, Horenstein NA. A Computational Analysis of the Factors Governing the Dynamics of α7 nAChR and Its Homologs. Biophysical Journal. PMID 33010233 DOI: 10.1016/j.bpj.2020.09.006  1
2020 Pismataro MC, Horenstein NA, Stokes C, Quadri M, De Amici M, Papke RL, Dallanoce C. Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation. European Journal of Medicinal Chemistry. 205: 112669. PMID 32810771 DOI: 10.1016/J.Ejmech.2020.112669  1
2020 Papke RL, Garai S, Stokes C, Horenstein NA, Zimmerman AD, Abboud KA, Thakur GA. Differing activity profiles of the stereoisomers of 2,3,5,6TMP-TQS, a putative silent allosteric modulator of α7nAChR. Molecular Pharmacology. PMID 32690627 DOI: 10.1124/Mol.120.119958  1
2020 Lin M, Colon-Perez LM, Sambo DO, Miller DR, Lebowitz JJ, Jimenez-Rondan F, Cousins RJ, Horenstein N, Aydemir TB, Febo M, Khoshbouei H. Mechanism of manganese dysregulation of dopamine neuronal activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32576620 DOI: 10.1523/Jneurosci.2830-19.2020  0.44
2020 Gulsevin A, Papke RL, Horenstein N. In silico modeling of the α7 nicotinic acetylcholine receptor: new pharmacological challenges associated with multiple modes of signaling. Mini Reviews in Medicinal Chemistry. PMID 32000651 DOI: 10.2174/1389557520666200130105256  1
2019 Godin JR, Roy P, Quadri M, Bagdas D, Toma W, Narendrula-Kotha R, Kishta OA, Damaj MI, Horenstein NA, Papke RL, Simard AR. A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE. Brain, Behavior, and Immunity. PMID 31874200 DOI: 10.1016/J.Bbi.2019.12.014  1
2019 Nuñez C, Horenstein NA. Functional Analysis of a Gene Cluster from Involved in Biosynthesis of the Pyrrolidine Azasugar DAB-1. Journal of Natural Products. PMID 31793783 DOI: 10.1021/Acs.Jnatprod.9B00758  0.2
2019 Stokes C, Garai S, Kulkarni AR, Cantwell LN, Noviello CM, Hibbs RE, Horenstein NA, Abboud KA, Thakur GA, Papke RL. Heteromeric neuronal nicotinic acetylcholine receptors with mutant beta subunits acquire sensitivity to α7-selective positive allosteric modulators. The Journal of Pharmacology and Experimental Therapeutics. PMID 31175218 DOI: 10.1124/Jpet.119.259499  1
2019 Gulsevin A, Papke RL, Stokes C, Thakur GA, Quadri M, Horenstein N. Allosteric agonism of α7 nicotinic acetylcholine receptors. Molecular Pharmacology. PMID 30944209 DOI: 10.1124/Mol.119.115758  1
2019 Murray AB, Quadri M, Li H, McKenna R, Horenstein NA. Synthesis of saccharin-glycoconjugates targeting carbonic anhydrase using a one-pot cyclization/deprotection strategy. Carbohydrate Research. 476: 65-70. PMID 30921738 DOI: 10.1016/J.Carres.2019.03.001  1
2018 Quadri M, Garai S, Thakur GA, Stokes C, Gulsevin A, Horenstein NA, Papke RL. Macroscopic and microscopic activation of α7 nicotinic acetylcholine receptors by the structurally unrelated ago-PAMs B-973B and GAT107. Molecular Pharmacology. PMID 30348894 DOI: 10.1124/Mol.118.113340  1
2018 Quadri M, Silnović A, Matera C, Horenstein NA, Stokes C, De Amici M, Papke RL, Dallanoce C. Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation. European Journal of Medicinal Chemistry. 160: 207-228. PMID 30342362 DOI: 10.1016/J.Ejmech.2018.10.015  1
2018 Quadri M, Bagdas D, Toma W, Stokes C, Horenstein NA, Damaj MI, Papke RL. The antinociceptive and anti-inflammatory properties of the α7 nAChR weak partial agonist -CF-diethyl--phenylpiperazine. The Journal of Pharmacology and Experimental Therapeutics. PMID 30111636 DOI: 10.1124/Jpet.118.249904  1
2018 Arciola JM, Horenstein NA. Characterization of the PLP-dependent Transaminase Initiating Azasugar Biosynthesis. The Biochemical Journal. PMID 29907615 DOI: 10.1042/Bcj20180340  1
2017 Horenstein NA, Quadri M, Stokes C, Shoaib M, Papke RL. Cracking the Betel Nut: Cholinergic Activity of Areca Alkaloids and Related Compounds. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 29059390 DOI: 10.1093/Ntr/Ntx187  1
2017 Horenstein NA, Papke RL. Anti-inflammatory Silent Agonists. Acs Medicinal Chemistry Letters. 8: 989-991. PMID 29057037 DOI: 10.1021/Acsmedchemlett.7B00368  1
2017 Quadri M, Stokes C, Gulsevin A, Felts ACJ, Abboud KA, Papke RL, Horenstein NA. Sulfonium as a surrogate for Ammonium: A new α7 nicotinic acetylcholine receptor partial agonist with desensitizing activity. Journal of Medicinal Chemistry. PMID 28885019 DOI: 10.1021/Acs.Jmedchem.7B00875  1
2017 Dallanoce CML, Quadri M, Matera C, Silnović A, Pismataro MC, Horenstein NA, Stokes C, Papke RL. Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists based on the Spirocyclic Quinuclidine-Δ2-Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation. Chemmedchem. PMID 28494140 DOI: 10.1002/Cmdc.201700162  1
2017 Papke RL, Stokes C, Damaj MI, Thakur GA, Manther K, Treinin M, Bagdas D, Kulkarni AR, Horenstein NA. Persistent activation of α7 nAChRs associated with stable induction of different desensitized states. British Journal of Pharmacology. PMID 28477386 DOI: 10.1111/Bph.13851  1
2016 Thiaville JJ, Frelin O, García-Salinas C, Harrison K, Hasnain G, Horenstein NA, Díaz de la Garza RI, Henry CS, Hanson AD, de Crécy-Lagard V. Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB). Frontiers in Microbiology. 7: 431. PMID 27065985 DOI: 10.3389/Fmicb.2016.00431  1
2016 Horenstein NA, Papke RL, Kulkarni AR, Chaturbhuj GU, Stokes C, Manther K, Thakur GA. Critical molecular determinants of α7 nicotinic acetylcholine receptor allosteric activation: separation of direct allosteric activation and positive allosteric modulation. The Journal of Biological Chemistry. PMID 26742843 DOI: 10.1074/Jbc.M115.692392  1
2015 Quadri M, Papke RL, Horenstein NA. Dissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonists. Bioorganic & Medicinal Chemistry. PMID 26707847 DOI: 10.1016/J.Bmc.2015.12.017  1
2015 Papke RL, Horenstein NA, Stokes C. Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity. Plos One. 10: e0140907. PMID 26488401 DOI: 10.1371/Journal.Pone.0140907  1
2015 Ehsan MU, Bozai Y, Pearson Iii WL, Horenstein NA, Eyler JR. Infrared multiple photon dissociation spectrum of protonated bis(2-methoxyethyl) ether obtained with a tunable CO2 laser. Physical Chemistry Chemical Physics : Pccp. PMID 26007681 DOI: 10.1039/C5Cp01752A  1
2014 Akin D, Wang SK, Habibzadegah-Tari P, Law B, Ostrov D, Li M, Yin XM, Kim JS, Horenstein N, Dunn WA. A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors. Autophagy. 10: 2021-35. PMID 25483883 DOI: 10.4161/Auto.32229  1
2014 Papke RL, Chojnacka K, Horenstein NA. The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor. The Journal of Pharmacology and Experimental Therapeutics. 350: 665-80. PMID 24990939 DOI: 10.1124/Jpet.114.215236  1
2014 Papke RL, Horenstein NA, Kulkarni AR, Stokes C, Corrie LW, Maeng CY, Thakur GA. The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface. The Journal of Biological Chemistry. 289: 4515-31. PMID 24362025 DOI: 10.1074/Jbc.M113.524603  1
2014 Wu Y, Arciola J, Horenstein N. Medium-chain dehydrogenases with new specificity: Amino mannitol dehydrogenases on the azasugar biosynthetic pathway Protein and Peptide Letters. 21: 10-14. PMID 24354768 DOI: 10.2174/092986652101131219093413  1
2014 Akin D, Wang SK, Habibzadegah-Tari P, Law B, Ostrov D, Li M, Yin XM, Kim JS, Horenstein N, Dunn WA. A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors Autophagy. 10: 2021-2035. DOI: 10.4161/auto.32229  1
2013 Chojnacka K, Papke RL, Horenstein NA. Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor. Bioorganic & Medicinal Chemistry Letters. 23: 4145-9. PMID 23746476 DOI: 10.1016/J.Bmcl.2013.05.039  1
2013 Isaacson MD, Horenstein NA, Stokes C, Kem WR, Papke RL. Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines. Biochemical Pharmacology. 85: 817-28. PMID 23352650 DOI: 10.1016/J.Bcp.2013.01.010  1
2012 Wang J, Papke RL, Stokes C, Horenstein NA. Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 287: 21957-69. PMID 22556416 DOI: 10.1074/Jbc.M112.339796  1
2011 Pierdominici-Sottile G, Horenstein NA, Roitberg AE. Free energy study of the catalytic mechanism of Trypanosoma cruzi trans-sialidase. From the Michaelis complex to the covalent intermediate. Biochemistry. 50: 10150-8. PMID 22007596 DOI: 10.1021/Bi2009618  1
2011 Clark LF, Johnson JV, Horenstein NA. Identification of a gene cluster that initiates Azasugar biosynthesis in Bacillus amyloliquefaciens Chembiochem. 12: 2147-2150. PMID 21786380 DOI: 10.1002/Cbic.201100347  1
2011 Williams DK, Stokes C, Horenstein NA, Papke RL. The effective opening of nicotinic acetylcholine receptors with single agonist binding sites. The Journal of General Physiology. 137: 369-84. PMID 21444659 DOI: 10.1085/Jgp.201010587  1
2011 Papke RL, Stokes C, Williams DK, Wang J, Horenstein NA. Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper. Neuropharmacology. 60: 159-71. PMID 20650284 DOI: 10.1016/J.Neuropharm.2010.07.014  1
2010 Wang J, Horenstein NA, Stokes C, Papke RL. Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization. Molecular Pharmacology. 78: 1012-25. PMID 20823218 DOI: 10.1124/Mol.110.066662  1
2010 Delacruz J, Mikulski R, Tu C, Li Y, Wang H, Shiverick KT, Frost SC, Horenstein NA, Silverman DN. Detecting extracellular carbonic anhydrase activity using membrane inlet mass spectrometry. Analytical Biochemistry. 403: 74-8. PMID 20417171 DOI: 10.1016/J.Ab.2010.04.019  1
2010 Leonik FM, Ghiviriga I, Horenstein NA. Synthesis of 3, 5-diazabicyclo [5.1.0] octenes. A new platform to mimic glycosidase transition states Tetrahedron. 66: 5566-5572. DOI: 10.1016/J.Tet.2010.05.064  1
2009 Corsino P, Horenstein N, Ostrov D, Rowe T, Law M, Barrett A, Aslanidi G, Cress WD, Law B. A novel class of cyclin-dependent kinase inhibitors identified by molecular docking act through a unique mechanism Journal of Biological Chemistry. 284: 29945-29955. PMID 19710018 DOI: 10.1074/Jbc.M109.055251  1
2009 Williams DK, Stokes C, Horenstein NA, Papke RL. Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site. The Journal of Pharmacology and Experimental Therapeutics. 330: 40-53. PMID 19339660 DOI: 10.1124/Jpet.109.151225  1
2009 Papke RL, Kem WR, Soti F, López-Hernández GY, Horenstein NA. Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine. The Journal of Pharmacology and Experimental Therapeutics. 329: 791-807. PMID 19223664 DOI: 10.1124/Jpet.108.150151  1
2009 Wang J, Papke RL, Horenstein NA. Synthesis of H-bonding probes of alpha7 nAChR agonist selectivity. Bioorganic & Medicinal Chemistry Letters. 19: 474-6. PMID 19081250 DOI: 10.1016/J.Bmcl.2008.11.044  1
2008 Horenstein NA, Leonik FM, Papke RL. Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors. Molecular Pharmacology. 74: 1496-511. PMID 18768388 DOI: 10.1124/Mol.108.048892  1
2007 Leonik FM, Papke RL, Horenstein NA. Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. 17: 1520-2. PMID 17276680 DOI: 10.1016/J.Bmcl.2007.01.003  1
2007 Horenstein NA, McCormack TJ, Stokes C, Ren K, Papke RL. Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 282: 5899-909. PMID 17189260 DOI: 10.1074/Jbc.M609202200  1
2006 Horenstein NA. Mechanisms for nucleophilic aliphatic substitution at glycosides Advances in Physical Organic Chemistry. 41: 275-314. DOI: 10.1016/S0065-3160(06)41005-4  1
2005 Papke RL, Zheng G, Horenstein NA, Dwoskin LP, Crooks PA. The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. Bioorganic & Medicinal Chemistry Letters. 15: 3874-80. PMID 16005216 DOI: 10.1016/J.Bmcl.2005.05.118  1
2005 Papke RL, Schiff HC, Jack BA, Horenstein NA. Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist. Neuroscience Letters. 378: 140-4. PMID 15781147 DOI: 10.1016/J.Neulet.2004.12.025  1
2005 Papke RL, Buhr JD, Francis MM, Choi KI, Thinschmidt JS, Horenstein NA. The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Molecular Pharmacology. 67: 1977-90. PMID 15761116 DOI: 10.1124/Mol.105.011676  1
2005 Sun H, Abboud KA, Horenstein NA. A new route into hexahydro-cyclopenta[b]pyrrole-cis-3a,6-diols. Synthesis of constrained bicyclic analogues of pyrrolidine azasugars Tetrahedron. 61: 10462-10469. DOI: 10.1016/J.Tet.2005.08.055  1
2004 Stokes C, Papke JK, Horenstein NA, Kem WR, McCormack TJ, Papke RL. The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors. Molecular Pharmacology. 66: 14-24. PMID 15213292 DOI: 10.1124/Mol.66.1.14  1
2004 Papke RL, Meyer EM, Lavieri S, Bollampally SR, Papke TA, Horenstein NA, Itoh Y, Porter Papke JK. Effects at a distance in alpha 7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy. Neuropharmacology. 46: 1023-38. PMID 15081799 DOI: 10.1016/J.Neuropharm.2004.01.005  1
2004 Young JEP, Horenstein NA. Synthesis of endo-(3-azabicyclo[3.1.0]hex-6-yl)-methanol and derivatives as new geometric/charge mimics of glycosyltransfer transition states Tetrahedron Letters. 45: 9505-9507. DOI: 10.1016/J.Tetlet.2004.10.156  1
2004 Burke EE, Horenstein NA. Enzymatic synthesis of [1-14C-N-acetyl, P18O 2] cytidine monophosphate neuraminic acid Journal of Labelled Compounds and Radiopharmaceuticals. 47: 1007-1017. DOI: 10.1002/Jlcr.889  0.96
2002 Horenstein BA, Bruner M. Characterization of alpha(2-->6)-sialyltransferase reaction intermediates: use of alternative substrates to unmask kinetic isotope effects. Methods in Enzymology. 354: 159-68. PMID 12418223 DOI: 10.1016/S0076-6879(02)54012-X  0.88
2001 Papke RL, Horenstein BA, Placzek AN. Inhibition of wild-type and mutant neuronal nicotinic acetylcholine receptors by local anesthetics. Molecular Pharmacology. 60: 1365-74. PMID 11723244 DOI: 10.1124/Mol.60.6.1365  0.32
2000 Yang J, Schenkman S, Horenstein BA. Primary 13C and β-secondary 2H KIEs for trans-sialidase. A snapshot of nucleophilic participation during catalysis Biochemistry. 39: 5902-5910. PMID 10801342 DOI: 10.1021/BI000061+  0.56
2000 Bruner M, Horenstein BA. Use of an altered sugar-nucleotide to unmask the transition state for α(2→6) sialyltransferase Biochemistry. 39: 2261-2268. PMID 10694392 DOI: 10.1021/Bi991474H  0.64
1998 Bruner M, Horenstein BA. Isotope trapping and kinetic isotope effect studies of rat liver α- (2→6)-sialyltransferase Biochemistry. 37: 289-297. PMID 9425050 DOI: 10.1021/Bi971624T  0.92
1997 Parr IB, Horenstein BA. New Electronic Analogs of the Sialyl Cation: N-Functionalized 4-Acetamido-2,4-dihydroxypiperidines. Inhibition of Bacterial Sialidases. The Journal of Organic Chemistry. 62: 7489-7494. PMID 11671872 DOI: 10.1021/jo9708497  0.32
1994 Schramm VL, Horenstein BA, Kline PC. Transition state analysis and inhibitor design for enzymatic reactions Journal of Biological Chemistry. 269: 18259-18262. PMID 8034566  0.48
1993 Horenstein BA, Schramm VL. Correlation of the molecular electrostatic potential surface of an enzymatic transition state with novel transition-state inhibitors Biochemistry. 32: 9917-9925. PMID 8399161 DOI: 10.1021/Bi00089A007  0.88
1993 Horenstein BA, Schramm VL. Electronic nature of the transition state for nucleoside hydrolase. A blueprint for inhibitor design Biochemistry. 32: 7089-7097. PMID 8343502 DOI: 10.1021/Bi00079A004  0.84
1991 Parkin DW, Mentch F, Banks GA, Horenstein BA, Schramm VL. Transition-state analysis of a Vmax mutant of AMP nucleosidase by the application of heavy-atom kinetic isotope effects. Biochemistry. 30: 4586-94. PMID 2021651 DOI: 10.1021/Bi00232A032  0.64
1991 Parkin DW, Horenstein BA, Abdulah DR, Estupiñán B, Schramm VL. Nucleoside hydrolase from Crithidia fasciculata: Metabolic role, purification, specificity, and kinetic mechanism Journal of Biological Chemistry. 266: 20658-20665. PMID 1939115  0.52
1991 Horenstein BA, Parkin DW, Estupiñán B, Schramm VL. Transition-State Analysis of Nucleoside Hydrorlase from Crithidia fasciculata Biochemistry. 30: 10788-10795. PMID 1931998 DOI: 10.1021/Bi00108A026  0.64
1990 Gittinger JP, Chernick S, Horenstein NR, Saito K. Household food security and the role of women World Bank Discussion Papers. 96.  1
1983 Burfisher ME, Horenstein NR. Incorporating women into agricultural development planning: a methodology. Rural Development: Growth and Inequity. Papers From 18th Iaae Conference. 161-165.  1
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