Jonathan R. Lai - Publications

Affiliations: 
Biochemistry Albert Einstein College of Medicine, New York, New York, United States 
Area:
Biochemistry, Chemical Biology, Protein Chemistry

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Román-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, ... ... Lai JR, et al. Protocadherin-1 is essential for cell entry by New World hantaviruses. Nature. 563: 559-563. PMID 30464266 DOI: 10.1038/s41586-018-0702-1  0.4
2018 Nyakatura EK, Zak SE, Wec AZ, Hofmann D, Shulenin S, Bakken RR, Aman MJ, Chandran K, Dye JM, Lai JR. Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins. The Journal of Biological Chemistry. PMID 29500195 DOI: 10.1074/jbc.RA117.001627  0.4
2017 Hofmann D, Zak SE, Nyakatura EK, Mittler E, Bakken RR, Chandran K, Dye JM, Lai JR. Mechanistic and Fc Requirements for Inhibition of Sudan Virus Entry and In Vivo Protection by a Synthetic Antibody. Immunology Letters. PMID 28890093 DOI: 10.1016/j.imlet.2017.09.002  0.4
2016 Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, ... ... Lai JR, et al. A "Trojan horse" bispecific antibody strategy for broad protection against ebolaviruses. Science (New York, N.Y.). PMID 27608667 DOI: 10.1126/science.aag3267  1
2016 Howell KA, Qiu X, Brannan JM, Bryan C, Davidson E, Holtsberg FW, Wec AZ, Shulenin S, Biggins JE, Douglas R, Enterlein SG, Turner HL, Pallesen J, Murin CD, He S, ... ... Lai JR, et al. Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site. Cell Reports. PMID 27160900 DOI: 10.1016/j.celrep.2016.04.026  1
2016 Frei JC, Nyakatura EK, Zak SE, Bakken RR, Chandran K, Dye JM, Lai JR. Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses. Scientific Reports. 6: 19193. PMID 26758505 DOI: 10.1038/srep19193  1
2015 Uchime O, Dai Z, Biris N, Lee D, Sidhu SS, Li S, Lai JR, Gavathiotis E. Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. The Journal of Biological Chemistry. PMID 26565029 DOI: 10.1074/jbc.M115.680918  1
2015 Frei JC, Kielian M, Lai JR. Comprehensive mapping of functional epitopes on dengue virus glycoprotein E DIII for binding to broadly neutralizing antibodies 4E11 and 4E5A by phage display. Virology. 485: 371-82. PMID 26339794 DOI: 10.1016/j.virol.2015.08.011  1
2015 Nyakatura EK, Frei JC, Lai JR. Chemical and Structural Aspects of Ebola Virus Entry Inhibitors. Acs Infectious Diseases. 1: 42-52. PMID 25984565 DOI: 10.1021/id500025n  1
2015 Liu N, Tao Y, Brenowitz MD, Girvin ME, Lai JR. Structural and Functional Studies on the Marburg Virus GP2 Fusion Loop. The Journal of Infectious Diseases. PMID 25786917 DOI: 10.1093/infdis/jiv030  1
2015 Malashkevich VN, Higgins CD, Almo SC, Lai JR. A switch from parallel to antiparallel strand orientation in a coiled-coil X-ray structure via two core hydrophobic mutations. Biopolymers. 104: 178-85. PMID 25753192 DOI: 10.1002/bip.22631  0.4
2015 Dai Z, Tao Y, Liu N, Brenowitz MD, Girvin ME, Lai JR. Conditional trimerization and lytic activity of HIV-1 gp41 variants containing the membrane-associated segments. Biochemistry. 54: 1589-99. PMID 25658332 DOI: 10.1021/bi501376f  1
2014 Chen G, Koellhoffer JF, Zak SE, Frei JC, Liu N, Long H, Ye W, Nagar K, Pan G, Chandran K, Dye JM, Sidhu SS, Lai JR. Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge. Acs Chemical Biology. 9: 2263-73. PMID 25140871 DOI: 10.1021/cb5006454  1
2014 Higgins CD, Malashkevich VN, Almo SC, Lai JR. Influence of a heptad repeat stutter on the pH-dependent conformational behavior of the central coiled-coil from influenza hemagglutinin HA2. Proteins. 82: 2220-8. PMID 24753307 DOI: 10.1002/prot.24585  1
2014 Koellhoffer JF, Dai Z, Malashkevich VN, Stenglein MD, Liu Y, Toro R, S Harrison J, Chandran K, DeRisi JL, Almo SC, Lai JR. Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species. Journal of Molecular Biology. 426: 1452-68. PMID 24333483 DOI: 10.1016/j.jmb.2013.12.009  1
2014 Koellhoffer JF, Higgins CD, Lai JR. Protein engineering strategies for the development of viral vaccines and immunotherapeutics Febs Letters. 588: 298-307. PMID 24157357 DOI: 10.1016/j.febslet.2013.10.014  1
2013 Higgins CD, Koellhoffer JF, Chandran K, Lai JR. C-peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: effects of conjugation to cholesterol and side chain-side chain crosslinking. Bioorganic & Medicinal Chemistry Letters. 23: 5356-60. PMID 23962564 DOI: 10.1016/j.bmcl.2013.07.056  1
2013 Liu Y, Higgins CD, Overstreet CM, Rai KR, Chiorazzi N, Lai JR. Peptides that bind specifically to an antibody from a chronic lymphocytic leukemia clone expressing unmutated immunoglobulin variable region genes Molecular Medicine. 19: 245-252. PMID 23922242 DOI: 10.2119/molmed.2013.00082  1
2013 Harrison JS, Higgins CD, O'Meara MJ, Koellhoffer JF, Kuhlman BA, Lai JR. Role of electrostatic repulsion in controlling pH-dependent conformational changes of viral fusion proteins. Structure (London, England : 1993). 21: 1085-96. PMID 23823327 DOI: 10.1016/j.str.2013.05.009  1
2013 Regula LK, Harris R, Wang F, Higgins CD, Koellhoffer JF, Zhao Y, Chandran K, Gao J, Girvin ME, Lai JR. Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids. Biochemistry. 52: 3393-404. PMID 23650881 DOI: 10.1021/bi400040v  1
2013 Stewart A, Harrison JS, Regula LK, Lai JR. Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the VH1-69 germline segment Bmc Biochemistry. 14. PMID 23566198 DOI: 10.1186/1471-2091-14-9  1
2012 Koellhoffer JF, Chen G, Sandesara RG, Bale S, Saphire EO, Chandran K, Sidhu SS, Lai JR. Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein. Chembiochem : a European Journal of Chemical Biology. 13: 2549-57. PMID 23111988 DOI: 10.1002/cbic.201200493  1
2012 Koellhoffer JF, Malashkevich VN, Harrison JS, Toro R, Bhosle RC, Chandran K, Almo SC, Lai JR. Crystal structure of the Marburg virus GP2 core domain in its postfusion conformation. Biochemistry. 51: 7665-75. PMID 22935026 DOI: 10.1021/bi300976m  1
2012 Harrison JS, Koellhoffer JF, Chandran K, Lai JR. Marburg virus glycoprotein GP2: pH-dependent stability of the ectodomain α-helical bundle. Biochemistry. 51: 2515-25. PMID 22369502 DOI: 10.1021/bi3000353  1
2012 Stewart A, Liu Y, Lai JR. A strategy for phage display selection of functional domain-exchanged immunoglobulin scaffolds with high affinity for glycan targets Journal of Immunological Methods. 376: 150-155. PMID 22233878 DOI: 10.1016/j.jim.2011.12.008  1
2011 Liu Y, Regula LK, Stewart A, Lai JR. Synthetic Fab fragments that bind the HIV-1 gp41 heptad repeat regions Biochemical and Biophysical Research Communications. 413: 611-615. PMID 21925149 DOI: 10.1016/j.bbrc.2011.09.012  1
2011 Harrison JS, Higgins CD, Chandran K, Lai JR. Designed protein mimics of the Ebola virus glycoprotein GP2 α-helical bundle: stability and pH effects. Protein Science : a Publication of the Protein Society. 20: 1587-96. PMID 21739501 DOI: 10.1002/pro.688  1
2011 Miller EH, Harrison JS, Radoshitzky SR, Higgins CD, Chi X, Dong L, Kuhn JH, Bavari S, Lai JR, Chandran K. Inhibition of Ebola virus entry by a C-peptide targeted to endosomes. The Journal of Biological Chemistry. 286: 15854-61. PMID 21454542 DOI: 10.1074/jbc.M110.207084  1
2010 Da Silva GF, Harrison JS, Lai JR. Contribution of light chain residues to high affinity binding in an hiv-1 antibody explored by combinatorial scanning mutagenesis Biochemistry. 49: 5464-5472. PMID 20518570 DOI: 10.1021/bi100293q  1
2009 Lu Z, Lai J, Zhang Y. Importance of charge independent effects in readout of the trimethyllysine mark by HP1 chromodomain. Journal of the American Chemical Society. 131: 14928-31. PMID 19788305 DOI: 10.1021/ja904951t  1
2008 Pomerantz WC, Grygiel TL, Lai JR, Gellman SH. Distinctive circular dichroism signature for 14-helix-bundle formation by beta-peptides. Organic Letters. 10: 1799-802. PMID 18396884 DOI: 10.1021/ol800622e  1
2007 Fischbach MA, Lai JR, Roche ED, Walsh CT, Liu DR. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proceedings of the National Academy of Sciences of the United States of America. 104: 11951-6. PMID 17620609 DOI: 10.1073/pnas.0705348104  1
2007 Zhou Z, Lai JR, Walsh CT. Directed evolution of aryl carrier proteins in the enterobactin synthetase. Proceedings of the National Academy of Sciences of the United States of America. 104: 11621-6. PMID 17606920 DOI: 10.1073/pnas.0705122104  1
2006 Lai JR, Epand RF, Weisblum B, Epand RM, Gellman SH. Roles of salt and conformation in the biological and physicochemical behavior of protegrin-1 and designed analogues: correlation of antimicrobial, hemolytic, and lipid bilayer-perturbing activities. Biochemistry. 45: 15718-30. PMID 17176094 DOI: 10.1021/bi0617759  1
2006 Lai JR, Koglin A, Walsh CT. Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis. Biochemistry. 45: 14869-79. PMID 17154525 DOI: 10.1021/bi061979p  1
2006 Zhou Z, Lai JR, Walsh CT. Interdomain communication between the thiolation and thioesterase domains of EntF explored by combinatorial mutagenesis and selection. Chemistry & Biology. 13: 869-79. PMID 16931336 DOI: 10.1016/j.chembiol.2006.06.011  1
2006 Lai JR, Fischbach MA, Liu DR, Walsh CT. Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. Journal of the American Chemical Society. 128: 11002-3. PMID 16925399 DOI: 10.1021/ja063238h  1
2006 Lai JR, Fischbach MA, Liu DR, Walsh CT. A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. Proceedings of the National Academy of Sciences of the United States of America. 103: 5314-9. PMID 16567620 DOI: 10.1073/pnas.0601038103  1
2004 Lai JR, Fisk JD, Weisblum B, Gellman SH. Hydrophobic core repacking in a coiled-coil dimer via phage display: insights into plasticity and specificity at a protein-protein interface. Journal of the American Chemical Society. 126: 10514-5. PMID 15327289 DOI: 10.1021/ja047710f  1
2003 Park JS, Lee HS, Lai JR, Kim BM, Gellman SH. Accommodation of alpha-substituted residues in the beta-peptide 12-helix: expanding the range of substitution patterns available to a foldamer scaffold. Journal of the American Chemical Society. 125: 8539-45. PMID 12848561 DOI: 10.1021/ja034180z  1
2003 Raguse TL, Lai JR, Gellman SH. Environment-independent 14-helix formation in short beta-peptides: striking a balance between shape control and functional diversity. Journal of the American Chemical Society. 125: 5592-3. PMID 12733872 DOI: 10.1021/ja0341485  1
2003 Lai JR, Gellman SH. Reinvestigation of the proposed folding and self-association of the Neuropeptide Head Activator. Protein Science : a Publication of the Protein Society. 12: 560-6. PMID 12592026 DOI: 10.1110/ps.0232103  1
2002 Lai JR, Huck BR, Weisblum B, Gellman SH. Design of non-cysteine-containing antimicrobial beta-hairpins: structure-activity relationship studies with linear protegrin-1 analogues. Biochemistry. 41: 12835-42. PMID 12379126 DOI: 10.1021/bi026127d  1
2002 Raguse TL, Lai JR, Gellman SH. Evidence that the β-peptide 14-helix is stabilized by β3-residues with side-chain branching adjacent to the β-carbon atom Helvetica Chimica Acta. 85: 4154-4164. DOI: 10.1002/hlca.200290001  1
2001 Raguse TL, Lai JR, LePlae PR, Gellman SH. Toward beta-peptide tertiary structure: self-association of an amphiphilic 14-helix in aqueous solution. Organic Letters. 3: 3963-6. PMID 11720580 DOI: 10.1021/ol016868r  1
2001 Woll MG, Lai JR, Guzei IA, Taylor SJ, Smith ME, Gellman SH. Parallel sheet secondary structure in gamma-peptides. Journal of the American Chemical Society. 123: 11077-8. PMID 11686719 DOI: 10.1021/ja011719p  1
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