| Year |
Citation |
Score |
| 2024 |
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H. Molecular mechanism of ligand gating and opening of NMDA receptor. Nature. 632: 209-217. PMID 39085540 DOI: 10.1038/s41586-024-07742-0 |
0.481 |
|
| 2023 |
Romero CA, Lim J, Wang H, Wynne BM, Ma P, Jing Y, Liotta DC, D'Erasmo M, Traynelis SF, Eaton DC, Wall SM. Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation. Biorxiv : the Preprint Server For Biology. PMID 38106229 DOI: 10.1101/2023.12.04.569973 |
0.493 |
|
| 2023 |
D'Erasmo MP, Akins NS, Ma P, Jing Y, Swanger SA, Sharma SK, Bartsch PW, Menaldino DS, Arcoria PJ, Bui TT, Pons-Bennaceur A, Le P, Allen JP, Ullman EZ, Nocilla KA, ... ... Liotta DC, et al. Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the -Methyl-d-aspartate Receptor. Acs Chemical Neuroscience. PMID 37566734 DOI: 10.1021/acschemneuro.3c00181 |
0.81 |
|
| 2023 |
Harris LD, Regan MC, Myers SJ, Nocilla KA, Akins NS, Tahirovic YA, Wilson LJ, Dingledine R, Furukawa H, Traynelis SF, Liotta DC. Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model. Acs Chemical Neuroscience. PMID 36779874 DOI: 10.1021/acschemneuro.2c00779 |
0.484 |
|
| 2022 |
Jecs E, Tahirovic YA, Wilson RJ, Miller EJ, Kim M, Truax V, Nguyen HH, Akins NS, Saindane M, Wang T, Sum CS, Cvijic ME, Schroeder GM, Burton SL, Derdeyn CA, ... ... Liotta DC, et al. Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles. Journal of Medicinal Chemistry. PMID 35179893 DOI: 10.1021/acs.jmedchem.1c01564 |
0.504 |
|
| 2021 |
Nguyen HH, Tahirovic YA, Truax VM, Wilson RJ, Jecs E, Miller EJ, Kim MB, Akins NS, Xu L, Jiang Y, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, ... Liotta DC, et al. Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings. Acs Medicinal Chemistry Letters. 12: 1605-1612. PMID 34676043 DOI: 10.1021/acsmedchemlett.1c00449 |
0.489 |
|
| 2021 |
Myers SJ, Ruppa KP, Wilson LJ, Tahirovic YA, Lyuboslavsky P, Menaldino DS, Dentmon ZW, Koszalka GW, Zaczek R, Dingledine RJ, Traynelis SF, Liotta DC. . The Journal of Pharmacology and Experimental Therapeutics. PMID 34493631 DOI: 10.1124/jpet.120.000370 |
0.528 |
|
| 2021 |
Perszyk RE, Zheng Z, Banke TG, Zhang J, Xie L, McDaniel MJ, Katzman BM, Pelly SC, Yuan H, Liotta DC, Traynelis SF. . Molecular Pharmacology. PMID 33688039 DOI: 10.1124/molpharm.120.000218 |
0.498 |
|
| 2020 |
Strong KL, Epplin MP, Ogden KK, Burger PB, Kaiser TM, Wilding TJ, Kusumoto H, Camp CR, Shaulsky G, Bhattacharya S, Perszyk RE, Menaldino DS, McDaniel MJ, Zhang J, Le P, ... ... Liotta DC, et al. Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of -Methyl-d-aspartate Receptors. Acs Chemical Neuroscience. PMID 33326224 DOI: 10.1021/acschemneuro.0c00561 |
0.538 |
|
| 2020 |
Epplin M, Mohan A, Harris L, Zhu Z, Strong KL, Bacsa J, Le P, Menaldino DS, Traynelis SF, Liotta DC. The Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-D-Aspartate (NMDA) Receptor. Journal of Medicinal Chemistry. PMID 32538088 DOI: 10.1021/Acs.Jmedchem.9B01733 |
0.587 |
|
| 2020 |
Zhu Z, Yi F, Epplin MP, Liu D, Summer SL, Mizu R, Shaulsky G, XiangWei W, Tang W, Burger PB, Menaldino DS, Myers SJ, Liotta DC, Hansen KB, Yuan H, et al. Negative allosteric modulation of GluN1/GluN3 NMDA receptors. Neuropharmacology. 108117. PMID 32389749 DOI: 10.1016/J.Neuropharm.2020.108117 |
0.57 |
|
| 2020 |
Pribut N, Kaiser TM, Wilson RJ, Jecs E, Dentmon ZW, Pelly S, Sharma SK, Bartsch P, Burger PB, Hwang S, Le T, Sourimant J, Yoon JJ, Plemper RK, Liotta DC. Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus. Acs Infectious Diseases. PMID 32275393 DOI: 10.1021/Acsinfecdis.9B00524 |
0.545 |
|
| 2020 |
McDaniel MJ, Ogden KK, Kell SA, Burger PB, Liotta DC, Traynelis SF. NMDA receptor channel gating control by the pre-M1 helix. The Journal of General Physiology. 152. PMID 32221541 DOI: 10.1085/Jgp.201912362 |
0.527 |
|
| 2020 |
Perszyk RE, Swanger SA, Shelley C, Khatri A, Fernandez-Cuervo G, Epplin MP, Zhang J, Le P, Bülow P, Garnier-Amblard E, Gangireddy PKR, Bassell GJ, Yuan H, Menaldino DS, Liotta DC, et al. Biased modulators of NMDA receptors control channel opening and ion selectivity. Nature Chemical Biology. PMID 31959964 DOI: 10.1038/S41589-019-0449-5 |
0.537 |
|
| 2019 |
Tahirovic YA, Pelly S, Jecs E, Miller EJ, Sharma SK, Liotta DC, Wilson LJ. Small molecule and peptide-based CXCR4 modulators as therapeutic agents. A patent review for the period from 2010 to 2018. Expert Opinion On Therapeutic Patents. PMID 31854208 DOI: 10.1080/13543776.2020.1707186 |
0.317 |
|
| 2019 |
Summer SL, Kell SA, Zhu Z, Moore R, Liotta DC, Myers SJ, Koszalka GW, Traynelis SF, Menaldino DS. Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor. Acs Medicinal Chemistry Letters. 10: 248-254. PMID 30891121 DOI: 10.1021/Acsmedchemlett.8B00395 |
0.717 |
|
| 2019 |
Regan MC, Zhu Z, Yuan H, Myers SJ, Menaldino DS, Tahirovic YA, Liotta DC, Traynelis SF, Furukawa H. Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors. Nature Communications. 10: 321. PMID 30659174 DOI: 10.2210/Pdb6E7S/Pdb |
0.531 |
|
| 2019 |
Katzman BM, Cox BD, Prosser AR, Alcaraz AA, Murat B, Héroux M, Tebben A, Zhang Y, Schroeder GM, Snyder JP, Wilson LJ, Liotta DC. Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor. Acs Medicinal Chemistry Letters. 10: 67-73. PMID 30655949 DOI: 10.1021/Acsmedchemlett.8B00441 |
0.675 |
|
| 2018 |
Shoji M, Qian WP, Nagaraju GP, Brat DJ, Pessolano D, Luzietti R, Chennamadhavuni S, Yamaguchi M, Yang L, Liotta DC. Inhibition of breast cancer metastasis to the lungs with UBS109. Oncotarget. 9: 36102-36109. PMID 30546830 DOI: 10.18632/Oncotarget.26302 |
0.764 |
|
| 2018 |
Wells G, Yuan H, McDaniel MJ, Kusumoto H, Snyder JP, Liotta DC, Traynelis SF. The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening. Proteins. PMID 30168177 DOI: 10.1002/Prot.25595 |
0.638 |
|
| 2018 |
Nguyen HH, Kim MB, Wilson RJ, Butch C, Kuo KM, Miller EJ, Tahirovic YA, Jecs E, Truax VM, Wang T, Sum C, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC. Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties. Journal of Medicinal Chemistry. PMID 30052039 DOI: 10.1021/Acs.Jmedchem.8B00450 |
0.57 |
|
| 2018 |
Gibb A, Ogden KK, McDaniel MJ, Vance KM, Kell SA, Butch C, Burger P, Liotta DC, Traynelis SF. A structurally-derived model of subunit-dependent NMDA receptor function. The Journal of Physiology. PMID 29917241 DOI: 10.1113/Jp276093 |
0.565 |
|
| 2018 |
Tahirovic YA, Truax VM, Wilson RJ, Jecs E, Nguyen HH, Miller EJ, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC. Discovery of -Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties. Acs Medicinal Chemistry Letters. 9: 446-451. PMID 29795757 DOI: 10.1021/Acsmedchemlett.8B00030 |
0.552 |
|
| 2018 |
Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF. An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups. Elife. 7. PMID 29792594 DOI: 10.7554/Elife.34711 |
0.705 |
|
| 2018 |
Huang MB, Giesler KE, Katzman BM, Prosser AR, Truax V, Liotta DC, Wilson LJ, Bond VC. Small molecule CXCR4 antagonists block the HIV-1 Nef/CXCR4 axis and selectively initiate the apoptotic program in breast cancer cells. Oncotarget. 9: 16996-17013. PMID 29682200 DOI: 10.18632/Oncotarget.24580 |
0.332 |
|
| 2018 |
Jecs E, Miller EJ, Wilson RJ, Nguyen HH, Tahirovic YA, Katzman BM, Truax VM, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Schroeder GM, Wilson LJ, Liotta DC. Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains. Acs Medicinal Chemistry Letters. 9: 89-93. PMID 29456793 DOI: 10.1021/Acsmedchemlett.7B00406 |
0.546 |
|
| 2018 |
Miller EJ, Jecs E, Truax VM, Katzman BM, Tahirovic YA, Wilson RJ, Kuo KM, Kim MB, Nguyen HH, Saindane MT, Zhao H, Wang T, Sum CS, Cvijic ME, Schroeder GM, ... ... Liotta DC, et al. Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in vitro ADMET Properties. Journal of Medicinal Chemistry. PMID 29350534 DOI: 10.1021/Acs.Jmedchem.7B01420 |
0.53 |
|
| 2018 |
Wilson RJ, Jecs E, Miller EJ, Nguyen HH, Tahirovic YA, Truax VM, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Paiva AA, Schroeder GM, Wilson LJ, Liotta DC. Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists. Acs Medicinal Chemistry Letters. 9: 17-22. PMID 29348805 DOI: 10.1021/Acsmedchemlett.7B00381 |
0.542 |
|
| 2018 |
Perszyk R, Katzman BM, Kusumoto H, Kell SA, Epplin MP, Tahirovic YA, Moore RL, Menaldino D, Burger P, Liotta DC, Traynelis SF. Author response: An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups Elife. DOI: 10.7554/Elife.34711.058 |
0.661 |
|
| 2017 |
Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB. The bioactive protein-ligand conformation of GluN2C-selective positive allosteric modulators bound to the NMDA receptor. Molecular Pharmacology. PMID 29242355 DOI: 10.1124/Mol.117.110940 |
0.587 |
|
| 2017 |
Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Bundgaard C, Mosley CA, Summer SL, Menaldino DS, Jensen HS, Liotta DC, Traynelis SF. A novel negative allosteric modulator selective for GluN2C/2D-containing NMDA receptors inhibits synaptic transmission in hippocampal interneurons. Acs Chemical Neuroscience. PMID 29043770 DOI: 10.1021/Acschemneuro.7B00329 |
0.794 |
|
| 2017 |
Strong KL, Epplin MP, Bacsa J, Butch CJ, Burger PB, Menaldino DS, Traynelis SF, Liotta DC. The Structure Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-ᴅ-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-ᴅ-Aspartate Receptors. Journal of Medicinal Chemistry. PMID 28586221 DOI: 10.1021/Acs.Jmedchem.7B00239 |
0.616 |
|
| 2017 |
Jimenez-Somarribas A, Mao S, Yoon JJ, Weisshaar M, Cox RM, Marengo JR, Mitchell DG, Morehouse ZP, Yan D, Solis I, Liotta DC, Natchus MG, Plemper RK. Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex. Journal of Medicinal Chemistry. PMID 28245119 DOI: 10.1021/Acs.Jmedchem.6B01568 |
0.587 |
|
| 2017 |
Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Journal of Chemical Information and Modeling. PMID 28244743 DOI: 10.1021/Acs.Jcim.7B00105 |
0.305 |
|
| 2017 |
Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Acs Chemical Neuroscience. PMID 28244737 DOI: 10.1021/Acschemneuro.7B00064 |
0.305 |
|
| 2017 |
Perszyk RE, Ogden KK, Strong KL, Liotta DC, Traynelis SF. Channel Open Probability Controls Allosteric Modulation of Potency and Efficacy Biophysical Journal. 112: 420a-421a. DOI: 10.1016/J.Bpj.2016.11.2249 |
0.491 |
|
| 2016 |
Liotta DC, Painter GR. Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC). Accounts of Chemical Research. PMID 27704821 DOI: 10.1021/Acs.Accounts.6B00274 |
0.305 |
|
| 2016 |
Perszyk RE, DiRaddo JO, Strong KL, Low CM, Ogden KK, Khatri A, Vargish GA, Pelkey KA, Tricoire L, Liotta DC, Smith Y, McBain CJ, Traynelis SF. GluN2D-containing NMDA receptors mediate synaptic transmission in hippocampal interneurons and regulate interneuron activity. Molecular Pharmacology. PMID 27625038 DOI: 10.1124/Mol.116.105130 |
0.529 |
|
| 2016 |
Giesler KE, Marengo J, Liotta DC. Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity. Journal of Medicinal Chemistry. PMID 27405794 DOI: 10.1021/Acs.Jmedchem.6B00428 |
0.324 |
|
| 2016 |
Miller EJ, Mays SG, Baillie MT, Howard RB, Culver DG, Saindane M, Pruett ST, Holt JJ, Menaldino DS, Evers TJ, Reddy GP, Arrendale RF, Natchus MG, Petros JA, Liotta DC. Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties. Acs Medicinal Chemistry Letters. 7: 537-42. PMID 27190606 DOI: 10.1021/Acsmedchemlett.6B00113 |
0.775 |
|
| 2015 |
Katzman BM, Perszyk RE, Yuan H, Tahirovic YA, Sotimehin AE, Traynelis SF, Liotta DC. A novel class of negative allosteric modulators of NMDA receptor function. Bioorganic & Medicinal Chemistry Letters. 25: 5583-8. PMID 26525866 DOI: 10.1016/J.Bmcl.2015.10.046 |
0.579 |
|
| 2015 |
Cox BD, Mehta AK, DiRaddo JO, Liotta DC, Wilson LJ, Snyder JP. Structural analysis of CXCR4 - Antagonist interactions using saturation-transfer double-difference NMR. Biochemical and Biophysical Research Communications. 466: 28-32. PMID 26301631 DOI: 10.1016/J.Bbrc.2015.08.084 |
0.521 |
|
| 2015 |
Cox BD, Prosser AR, Sun Y, Li Z, Lee S, Huang MB, Bond VC, Snyder JP, Krystal M, Wilson LJ, Liotta DC. Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase. Acs Medicinal Chemistry Letters. 6: 753-7. PMID 26191361 DOI: 10.1021/Acsmedchemlett.5B00036 |
0.523 |
|
| 2015 |
DiRaddo JO, Miller EJ, Bowman-Dalley C, Wroblewska B, Javidnia M, Grajkowska E, Wolfe BB, Liotta DC, Wroblewski JT. Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors. Molecular Pharmacology. 88: 450-9. PMID 26089372 DOI: 10.1124/Mol.114.096420 |
0.337 |
|
| 2015 |
Zhao H, Prosser AR, Liotta DC, Wilson LJ. Discovery of novel N-aryl piperazine CXCR4 antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 25935642 DOI: 10.1016/J.Bmcl.2015.04.036 |
0.359 |
|
| 2015 |
Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC. Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators". Journal of Medicinal Chemistry. 58: 2862. PMID 25738634 DOI: 10.1021/Acs.Jmedchem.5B00199 |
0.562 |
|
| 2015 |
Yuan H, Myers SJ, Wells G, Nicholson KL, Swanger SA, Lyuboslavsky P, Tahirovic YA, Menaldino DS, Ganesh T, Wilson LJ, Liotta DC, Snyder JP, Traynelis SF. Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects. Neuron. 85: 1305-18. PMID 25728572 DOI: 10.1016/J.Neuron.2015.02.008 |
0.633 |
|
| 2015 |
Baldwin PR, Reeves AZ, Powell KR, Napier RJ, Swimm AI, Sun A, Giesler K, Bommarius B, Shinnick TM, Snyder JP, Liotta DC, Kalman D. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 92: 693-9. PMID 25618016 DOI: 10.1016/J.Ejmech.2015.01.020 |
0.475 |
|
| 2015 |
Zhu S, Kisiel W, Lu YJ, Petersen LC, Ndungu JM, Moore TW, Parker ET, Sun A, Sarkaria JN, Snyder JP, Liotta DC, Brat DJ, El-Rayes BF, Shoji M. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. Journal of Drug Targeting. 23: 257-65. PMID 25510254 DOI: 10.3109/1061186X.2014.988217 |
0.602 |
|
| 2014 |
Zhu S, Kisiel W, Lu YJ, Petersen LC, Ndungu JM, Moore TW, Parker ET, Sun A, Liotta DC, El-Rayes BF, Brat DJ, Snyder JP, Shoji M. Tumor angiogenesis therapy using targeted delivery of Paclitaxel to the vasculature of breast cancer metastases. Journal of Drug Delivery. 2014: 865732. PMID 25574399 DOI: 10.1155/2014/865732 |
0.618 |
|
| 2014 |
Strong KL, Jing Y, Prosser AR, Traynelis SF, Liotta DC. NMDA receptor modulators: an updated patent review (2013-2014). Expert Opinion On Therapeutic Patents. 24: 1349-66. PMID 25351527 DOI: 10.1517/13543776.2014.972938 |
0.571 |
|
| 2014 |
Zhou T, Ye L, Bai Y, Sun A, Cox B, Liu D, Li Y, Liotta D, Snyder JP, Fu H, Huang B. Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog. Plos One. 9: e107876. PMID 25268357 DOI: 10.1371/Journal.Pone.0107876 |
0.484 |
|
| 2014 |
Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Molecular Pharmacology. 86: 548-60. PMID 25205677 DOI: 10.1124/Mol.114.094516 |
0.665 |
|
| 2014 |
Cox BD, Prosser AR, Katzman BM, Alcaraz AA, Liotta DC, Wilson LJ, Snyder JP. Anti-HIV small-molecule binding in the peptide subpocket of the CXCR4:CVX15 crystal structure. Chembiochem : a European Journal of Chemical Biology. 15: 1614-20. PMID 24990206 DOI: 10.1002/Cbic.201402056 |
0.664 |
|
| 2014 |
Hu H, Mao S, Bugrysheva JV, Pruett S, Liotta DC, Scott JR, Snyder JP. Group A streptococcus inhibitors by high-throughput virtual screening. European Journal of Medicinal Chemistry. 82: 120-6. PMID 24880231 DOI: 10.1016/J.Ejmech.2014.05.006 |
0.778 |
|
| 2014 |
Santangelo Freel RM, Ogden KK, Strong KL, Khatri A, Chepiga KM, Jensen HS, Traynelis SF, Liotta DC. Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors. Journal of Medicinal Chemistry. 57: 4975. PMID 24878076 DOI: 10.1021/jm500710w |
0.515 |
|
| 2014 |
DiRaddo JO, Miller EJ, Hathaway HA, Grajkowska E, Wroblewska B, Wolfe BB, Liotta DC, Wroblewski JT. A real-time method for measuring cAMP production modulated by Gαi/o-coupled metabotropic glutamate receptors. The Journal of Pharmacology and Experimental Therapeutics. 349: 373-82. PMID 24659805 DOI: 10.1124/Jpet.113.211532 |
0.315 |
|
| 2014 |
Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC. Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators. Journal of Medicinal Chemistry. 57: 2334-56. PMID 24512267 DOI: 10.1021/Jm401695D |
0.584 |
|
| 2013 |
Truax VM, Zhao H, Katzman BM, Prosser AR, Alcaraz AA, Saindane MT, Howard RB, Culver D, Arrendale RF, Gruddanti PR, Evers TJ, Natchus MG, Snyder JP, Liotta DC, Wilson LJ. Discovery of tetrahydroisoquinoline-based CXCR4 antagonists. Acs Medicinal Chemistry Letters. 4: 1025-30. PMID 24936240 DOI: 10.1021/Ml400183Q |
0.703 |
|
| 2013 |
Moore TW, Sana K, Yan D, Krumm SA, Thepchatri P, Snyder JP, Marengo J, Arrendale RF, Prussia AJ, Natchus MG, Liotta DC, Plemper RK, Sun A. Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy. Acs Medicinal Chemistry Letters. 4: 762-767. PMID 23956816 DOI: 10.1021/Ml400166B |
0.769 |
|
| 2013 |
Acker TM, Khatri A, Vance KM, Slabber C, Bacsa J, Snyder JP, Traynelis SF, Liotta DC. Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists. Journal of Medicinal Chemistry. 56: 6434-56. PMID 23909910 DOI: 10.1021/Jm400652R |
0.804 |
|
| 2013 |
Santangelo Freel RM, Ogden KK, Strong KL, Khatri A, Chepiga KM, Jensen HS, Traynelis SF, Liotta DC. Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. Journal of Medicinal Chemistry. 56: 5351-81. PMID 23627311 DOI: 10.1021/Jm400177T |
0.6 |
|
| 2013 |
Brown A, Shi Q, Moore TW, Yoon Y, Prussia A, Maddox C, Liotta DC, Shim H, Snyder JP. Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties. Journal of Medicinal Chemistry. 56: 3456-66. PMID 23550937 DOI: 10.1021/Jm4002692 |
0.788 |
|
| 2013 |
Moore TW, Sana K, Yan D, Thepchatri P, Ndungu JM, Saindane MT, Lockwood MA, Natchus MG, Liotta DC, Plemper RK, Snyder JP, Sun A. Asymmetric synthesis of host-directed inhibitors of myxoviruses. Beilstein Journal of Organic Chemistry. 9: 197-203. PMID 23400228 DOI: 10.3762/Bjoc.9.23 |
0.798 |
|
| 2013 |
Mays SG, Baillie MT, Miller EJ, Bushnev AS, Pruett ST, Culver DG, Evers TJ, Gao J, Reddy GP, Natchus MG, Arrendale RF, Howard RB, Liotta DC, Petros JA. 330 FLUORINATION OF ENIGMOL IMPROVES TISSUE UPTAKE AND AFFECTS
IN VIVO
PROSTATE CANCER EFFICACY Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.1715 |
0.771 |
|
| 2012 |
Santangelo RM, Acker TM, Zimmerman SS, Katzman BM, Strong KL, Traynelis SF, Liotta DC. Novel NMDA receptor modulators: an update. Expert Opinion On Therapeutic Patents. 22: 1337-52. PMID 23009122 DOI: 10.1517/13543776.2012.728587 |
0.781 |
|
| 2012 |
Burger PB, Yuan H, Karakas E, Geballe M, Furukawa H, Liotta DC, Snyder JP, Traynelis SF. Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. Molecular Pharmacology. 82: 344-59. PMID 22596351 DOI: 10.1124/Mol.112.078568 |
0.791 |
|
| 2012 |
Kim J, Wang L, Li Y, Becnel KD, Frey KM, Garforth SJ, Prasad VR, Schinazi RF, Liotta DC, Anderson KS. Pre-steady state kinetic analysis of cyclobutyl derivatives of 2′-deoxyadenosine 5′-triphosphate as inhibitors of HIV-1 reverse transcriptase Bioorganic and Medicinal Chemistry Letters. 22: 4064-4067. PMID 22595174 DOI: 10.1016/J.Bmcl.2012.04.078 |
0.492 |
|
| 2012 |
Liang Z, Zhan W, Zhu A, Yoon Y, Lin S, Sasaki M, Klapproth JM, Yang H, Grossniklaus HE, Xu J, Rojas M, Voll RJ, Goodman MM, Arrendale RF, Liu J, ... ... Liotta DC, et al. Development of a unique small molecule modulator of CXCR4. Plos One. 7: e34038. PMID 22485156 DOI: 10.1371/Journal.Pone.0034038 |
0.695 |
|
| 2012 |
Ndungu JM, Krumm SA, Yan D, Arrendale RF, Reddy GP, Evers T, Howard R, Natchus MG, Saindane MT, Liotta DC, Plemper RK, Snyder JP, Sun A. Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics. Journal of Medicinal Chemistry. 55: 4220-30. PMID 22480182 DOI: 10.1021/Jm201699W |
0.51 |
|
| 2012 |
Boyle GA, Edlin CD, Li Y, Liotta DC, Morgans GL, Musonda CC. Enantioselective synthesis of the carbocyclic nucleoside (-)-abacavir Organic and Biomolecular Chemistry. 10: 1870-1876. PMID 22274412 DOI: 10.1039/C2Ob06775G |
0.491 |
|
| 2012 |
Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, Miller AH, Pace TW. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. International Immunopharmacology. 12: 368-77. PMID 22197802 DOI: 10.1016/J.Intimp.2011.12.009 |
0.615 |
|
| 2011 |
Garnier-Amblard EC, Mays SG, Arrendale RF, Baillie MT, Bushnev AS, Culver DG, Evers TJ, Holt JJ, Howard RB, Liebeskind LS, Menaldino DS, Natchus MG, Petros JA, Ramaraju H, Reddy GP, ... Liotta DC, et al. Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer. Acs Medicinal Chemistry Letters. 2: 438-43. PMID 24900327 DOI: 10.1021/Ml2000164 |
0.639 |
|
| 2011 |
Zhan W, Jiang Y, Sharma S, Brodie PJ, Bane S, Kingston DG, Liotta DC, Snyder JP. C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 14792-804. PMID 22127984 DOI: 10.1002/Chem.201102630 |
0.651 |
|
| 2011 |
Acker TM, Yuan H, Hansen KB, Vance KM, Ogden KK, Jensen HS, Burger PB, Mullasseril P, Snyder JP, Liotta DC, Traynelis SF. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Molecular Pharmacology. 80: 782-95. PMID 21807990 DOI: 10.1124/Mol.111.073239 |
0.807 |
|
| 2011 |
Symolon H, Bushnev A, Peng Q, Ramaraju H, Mays SG, Allegood JC, Pruett ST, Sullards MC, Dillehay DL, Liotta DC, Merrill AH. Enigmol: A novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer Molecular Cancer Therapeutics. 10: 648-657. PMID 21398423 DOI: 10.1158/1535-7163.Mct-10-0754 |
0.782 |
|
| 2011 |
Garnier-Amblard EC, Mays SG, Arrendale RF, Baillie MT, Bushnev AS, Culver DG, Evers TJ, Holt JJ, Howard RB, Liebeskind LS, Menaldino DS, Natchus MG, Petros JA, Ramaraju H, Reddy GP, ... Liotta DC, et al. Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer Acs Medicinal Chemistry Letters. 2: 438-443. DOI: 10.1021/ml2000164 |
0.585 |
|
| 2011 |
Wilson LJ, Liotta DC. Emergence of small-molecule CXCR4 antagonists as novel immune and hematopoietic system regulatory agents Drug Development Research. 72: 598-602. DOI: 10.1002/Ddr.20469 |
0.331 |
|
| 2010 |
Zhu A, Zhan W, Liang Z, Yoon Y, Yang H, Grossniklaus HE, Xu J, Rojas M, Lockwood M, Snyder JP, Liotta DC, Shim H. Dipyrimidine amines: A novel class of chemokine receptor type 4 antagonists with high specificity Journal of Medicinal Chemistry. 53: 8556-8568. PMID 21105715 DOI: 10.1021/Jm100786G |
0.697 |
|
| 2010 |
Heathcote DA, Patel H, Kroll SH, Hazel P, Periyasamy M, Alikian M, Kanneganti SK, Jogalekar AS, Scheiper B, Barbazanges M, Blum A, Brackow J, Siwicka A, Pace RD, Fuchter MJ, ... ... Liotta DC, et al. A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. Journal of Medicinal Chemistry. 53: 8508-22. PMID 21080703 DOI: 10.1021/Jm100732T |
0.787 |
|
| 2010 |
Mullasseril P, Hansen KB, Vance KM, Ogden KK, Yuan H, Kurtkaya NL, Santangelo R, Orr AG, Le P, Vellano KM, Liotta DC, Traynelis SF. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nature Communications. 1: 90. PMID 20981015 DOI: 10.1038/Ncomms1085 |
0.791 |
|
| 2010 |
Mosley CA, Acker TM, Hansen KB, Mullasseril P, Andersen KT, Le P, Vellano KM, Bräuner-Osborne H, Liotta DC, Traynelis SF. Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. Journal of Medicinal Chemistry. 53: 5476-90. PMID 20684595 DOI: 10.1021/Jm100027P |
0.802 |
|
| 2010 |
Thomas SL, Zhao J, Li Z, Lou B, Du Y, Purcell J, Snyder JP, Khuri FR, Liotta D, Fu H. Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochemical Pharmacology. 80: 1309-16. PMID 20615389 DOI: 10.1016/J.Bcp.2010.06.048 |
0.509 |
|
| 2010 |
Li Y, Soni PB, Liu L, Zhang X, Liotta DC, Lutz S. Synthesis of fluorescent nucleoside analogs as probes for 2′-deoxyribonucleoside kinases Bioorganic and Medicinal Chemistry Letters. 20: 841-843. PMID 20060716 DOI: 10.1016/J.Bmcl.2009.12.097 |
0.529 |
|
| 2010 |
Pandey KK, Snyder JP, Liotta DC, Musaev DG. Computational studies of transition metal selectivity of octapeptide repeat region of prion protein (PrP). The Journal of Physical Chemistry. B. 114: 1127-35. PMID 20020721 DOI: 10.1021/Jp909945E |
0.43 |
|
| 2010 |
Pandey KK, Snyder JP, Liotta DC, Musaev DG. Computational Studies of Transition Metal Selectivity of Octapeptide Repeat Region of Prion Protein (PrP) Journal of Physical Chemistry B. 114: 1127-1135. DOI: 10.1021/jp909945e |
0.356 |
|
| 2009 |
Sun A, Lu YJ, Hu H, Shoji M, Liotta DC, Snyder JP. Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism Bioorganic and Medicinal Chemistry Letters. 19: 6627-6631. PMID 19854644 DOI: 10.1016/J.Bmcl.2009.10.023 |
0.651 |
|
| 2009 |
Thepchatri P, Min J, Ganesh T, Du Y, Lewis I, Kurtkaya S, Prussia A, Li L, Sneed B, Plemper RK, Fu H, Liotta DC, Snyder JP, Dingledine R, Sun A. Cancer and virus leads by HTS, chemical design and SEA data mining. Current Topics in Medicinal Chemistry. 9: 1159-71. PMID 19807668 DOI: 10.2174/156802609789753581 |
0.771 |
|
| 2009 |
MacNevin CJ, Atif F, Sayeed I, Stein DG, Liotta DC. Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury. Journal of Medicinal Chemistry. 52: 6012-23. PMID 19791804 DOI: 10.1021/Jm900712N |
0.778 |
|
| 2009 |
Mosley CA, Myers SJ, Murray EE, Santangelo R, Tahirovic YA, Kurtkaya N, Mullasseril P, Yuan H, Lyuboslavsky P, Le P, Wilson LJ, Yepes M, Dingledine R, Traynelis SF, Liotta DC. Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. Bioorganic & Medicinal Chemistry. 17: 6463-80. PMID 19648014 DOI: 10.1016/J.Bmc.2009.05.085 |
0.807 |
|
| 2009 |
Ali S, Heathcote DA, Kroll SH, Jogalekar AS, Scheiper B, Patel H, Brackow J, Siwicka A, Fuchter MJ, Periyasamy M, Tolhurst RS, Kanneganti SK, Snyder JP, Liotta DC, Aboagye EO, et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Research. 69: 6208-15. PMID 19638587 DOI: 10.1158/0008-5472.Can-09-0301 |
0.785 |
|
| 2009 |
Liu L, Li Y, Liotta D, Lutz S. Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting. Nucleic Acids Research. 37: 4472-81. PMID 19474348 DOI: 10.1093/Nar/Gkp400 |
0.491 |
|
| 2009 |
Mosley CA, Wilson LJ, Wiseman JM, Skudlarek JW, Liotta DC. Recent patents regarding the discovery of small molecule CXCR4 antagonists. Expert Opinion On Therapeutic Patents. 19: 23-38. PMID 19441896 DOI: 10.1517/13543770802553483 |
0.738 |
|
| 2009 |
Thaiparambil J, Bender L, Kline E, Ganesh T, Snyder J, Liotta D, Marcus A. Vimentin: A Novel Chemopreventive Target for Breast Cancer Metastasis. Cancer Research. 69: 5063-5063. DOI: 10.1158/0008-5472.Sabcs-09-5063 |
0.509 |
|
| 2008 |
Tahirovic YA, Geballe M, Gruszecka-Kowalik E, Myers SJ, Lyuboslavsky P, Le P, French A, Irier H, Choi WB, Easterling K, Yuan H, Wilson LJ, Kotloski R, McNamara JO, Dingledine R, Liotta DC, et al. Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. Journal of Medicinal Chemistry. 51: 5506-21. PMID 18800760 DOI: 10.1021/Jm8002153 |
0.816 |
|
| 2008 |
Thomas SL, Zhong D, Zhou W, Malik S, Liotta D, Snyder JP, Hamel E, Giannakakou P. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle (Georgetown, Tex.). 7: 2409-17. PMID 18682687 DOI: 10.4161/Cc.6410 |
0.538 |
|
| 2008 |
Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP, Liotta D, Fu H. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Molecular Pharmacology. 74: 654-61. PMID 18577686 DOI: 10.1124/Mol.108.046201 |
0.499 |
|
| 2008 |
Ganesh T, Min J, Thepchatri P, Du Y, Li L, Lewis I, Wilson L, Fu H, Chiosis G, Dingledine R, Liotta D, Snyder JP, Sun A. Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling. Bioorganic & Medicinal Chemistry. 16: 6903-10. PMID 18571929 DOI: 10.1016/J.Bmc.2008.05.047 |
0.793 |
|
| 2008 |
Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC, Merrill AH. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols Journal of Lipid Research. 49: 1621-1639. PMID 18499644 DOI: 10.1194/Jlr.R800012-Jlr200 |
0.795 |
|
| 2008 |
Shoji M, Sun A, Kisiel W, Lu YJ, Shim H, McCarey BE, Nichols C, Parker ET, Pohl J, Mosley CA, Alizadeh AR, Liotta DC, Snyder JP. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. Journal of Drug Targeting. 16: 185-97. PMID 18365880 DOI: 10.1080/10611860801890093 |
0.757 |
|
| 2008 |
Zhan W, Jiang Y, Brodie PJ, Kingston DGI, Liotta DC, Snyder JP. Design and synthesis C6-C8 bridged epothilone a Organic Letters. 10: 1565-1568. PMID 18355076 DOI: 10.1021/Ol800422Q |
0.63 |
|
| 2008 |
MacNevin CJ, Moore RL, Liotta DC. Stereoselective synthesis of quaternary center bearing azetines and their β-amino acid derivatives Journal of Organic Chemistry. 73: 1264-1269. PMID 18186644 DOI: 10.1021/Jo7018202 |
0.779 |
|
| 2007 |
Zhan W, Liang Z, Zhu A, Kurtkaya S, Shim H, Snyder JP, Liotta DC. Discovery of small molecule CXCR4 antagonists Journal of Medicinal Chemistry. 50: 5655-5664. PMID 17958344 DOI: 10.1021/Jm070679I |
0.681 |
|
| 2007 |
Mosley CA, Liotta DC, Snyder JP. Highly active anticancer curcumin analogues. Advances in Experimental Medicine and Biology. 595: 77-103. PMID 17569206 DOI: 10.1007/978-0-387-46401-5_2 |
0.782 |
|
| 2007 |
Li Y, Mao S, Hager MW, Becnel KD, Schinazi RF, Liotta DC. Synthesis and evaluation of 2′-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents Bioorganic and Medicinal Chemistry Letters. 17: 3398-3401. PMID 17434736 DOI: 10.1016/J.Bmcl.2007.03.094 |
0.639 |
|
| 2006 |
Sun A, Prussia A, Zhan W, Murray EE, Doyle J, Cheng LT, Yoon JJ, Radchenko EV, Palyulin VA, Compans RW, Liotta DC, Plemper RK, Snyder JP. Nonpeptide inhibitors of measles virus entry Journal of Medicinal Chemistry. 49: 5080-5092. PMID 16913698 DOI: 10.1021/Jm0602559 |
0.794 |
|
| 2006 |
Sun A, Shoji M, Lu YJ, Liotta DC, Snyder JP. Synthesis of EF24-tripeptide chloromethyl ketone: A novel curcumin-related anticancer drug delivery system Journal of Medicinal Chemistry. 49: 3153-3158. PMID 16722634 DOI: 10.1021/Jm051141K |
0.502 |
|
| 2006 |
Doyle J, Prussia A, White LK, Sun A, Liotta DC, Snyder JP, Compans RW, Plemper RK. Two domains that control prefusion stability and transport competence of the measles virus fusion protein. Journal of Virology. 80: 1524-36. PMID 16415028 DOI: 10.1128/Jvi.80.3.1524-1536.2006 |
0.764 |
|
| 2005 |
Plemper RK, Doyle J, Sun A, Prussia A, Cheng LT, Rota PA, Liotta DC, Snyder JP, Compans RW. Design of a small-molecule entry inhibitor with activity against primary measles virus strains Antimicrobial Agents and Chemotherapy. 49: 3755-3761. PMID 16127050 DOI: 10.1128/Aac.49.9.3755-3761.2005 |
0.772 |
|
| 2005 |
Wiseman JM, McDonald FE, Liotta DC. 1-Deoxy-5-hydroxysphingolipids as new anticancer principles: an efficient procedure for stereoselective syntheses of 2-amino-3,5-diols. Organic Letters. 7: 3155-7. PMID 16018609 DOI: 10.1021/Ol050829O |
0.324 |
|
| 2005 |
Hernandez-Santiago BI, Chen H, Asif G, Beltran T, Mao S, Hurwitz SJ, Grier J, McClure HM, Chu CK, Liotta DC, Schinazi RF. Pharmacology and pharmacokinetics of the antiviral agent β-D-2′,3′-dideoxy-3′-oxa-5-fluorocytidine in cells and rhesus monkeys Antimicrobial Agents and Chemotherapy. 49: 2589-2597. PMID 15980324 DOI: 10.1128/Aac.49.7.2589-2597.2005 |
0.543 |
|
| 2005 |
Adams BK, Cai J, Armstrong J, Herold M, Lu YJ, Sun A, Snyder JP, Liotta DC, Jones DP, Shoji M. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism Anti-Cancer Drugs. 16: 263-275. PMID 15711178 DOI: 10.1097/00001813-200503000-00005 |
0.753 |
|
| 2004 |
Mao S, Bouygues M, Welch C, Biba M, Chilenski J, Schinazi RF, Liotta DC. Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent Bioorganic and Medicinal Chemistry Letters. 14: 4991-4994. PMID 15341966 DOI: 10.1016/J.Bmcl.2004.07.016 |
0.489 |
|
| 2004 |
Adams BK, Ferstl EM, Davis MC, Herold M, Kurtkaya S, Camalier RF, Hollingshead MG, Kaur G, Sausville EA, Rickles FR, Snyder JP, Liotta DC, Shoji M. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents Bioorganic and Medicinal Chemistry. 12: 3871-3883. PMID 15210154 DOI: 10.1016/J.Bmc.2004.05.006 |
0.785 |
|
| 2004 |
Painter GR, Almond MR, Mao S, Liotta DC. Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase Current Topics in Medicinal Chemistry. 4: 1035-1044. PMID 15193137 DOI: 10.2174/1568026043388358 |
0.554 |
|
| 2004 |
Plemper RK, Erlandson KJ, Lakdawala AS, Sun A, Prussia A, Boonsombat J, Aki-Sener E, Yalcin I, Yildiz I, Temiz-Arpaci O, Tekiner B, Liotta DC, Snyder JP, Compans RW. A target site for template-based design of measles virus entry inhibitors Proceedings of the National Academy of Sciences of the United States of America. 101: 5628-5633. PMID 15056763 DOI: 10.1073/Pnas.0308520101 |
0.788 |
|
| 2004 |
Ambhaikar NB, Herold M, Liotta DC. A uniquely accessible route to the diastereoselective synthesis of azetine derivatives Heterocycles. 62: 217-222. DOI: 10.3987/Com-03-S(P)56 |
0.777 |
|
| 2003 |
Menaldino DS, Bushnev A, Sun A, Liotta DC, Symolon H, Desai K, Dillehay DL, Peng Q, Wang E, Allegood J, Trotman-Pruett S, Sullards MC, Merrill AH. Sphingoid bases and de novo ceramide synthesis: Enzymes involved, pharmacology and mechanisms of action Pharmacological Research. 47: 373-381. PMID 12676511 DOI: 10.1016/S1043-6618(03)00054-9 |
0.332 |
|
| 2003 |
Ambhaikar NB, Snyder JP, Liotta DC. Diastereoselective addition of chlorotitanium enolate of N-acyl thiazolidinethione to O-methyl oximes: A novel, stereoselective synthesis of α,β-disubstituted β-amino carbonyl compounds via chiral auxiliary mediated azetine formation Journal of the American Chemical Society. 125: 3690-3691. PMID 12656586 DOI: 10.1021/Ja029871U |
0.785 |
|
| 2002 |
Desai K, Sullards MC, Allegood J, Wang E, Schmelz EM, Hartl M, Humpf HU, Liotta DC, Peng Q, Merrill AH. Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1585: 188-192. PMID 12531553 DOI: 10.1016/S1388-1981(02)00340-2 |
0.304 |
|
| 2002 |
Lakdawala AS, Morgan DM, Liotta DC, Lynn DG, Snyder JP. Dynamics and fluidity of amyloid fibrils: a model of fibrous protein aggregates. Journal of the American Chemical Society. 124: 15150-1. PMID 12487571 DOI: 10.1021/Ja0273290 |
0.719 |
|
| 2002 |
Ferstl EM, Venkatesan H, Ambhaikar NB, Snyder JP, Liotta DC. Thiazolidine-2-thione directed diastereoselective addition of chlorotitanium enolates to aldimines Synthesis. 2075-2083. DOI: 10.1055/S-2002-34375 |
0.766 |
|
| 2002 |
Morgan DM, Lynn DG, Lakdawala AS, Snyder JP, Liotta DC. Amyloid structure: Models and theoretical considerations in fibrous aggregates Journal of the Chinese Chemical Society. 49: 459-466. DOI: 10.1002/Jccs.200200072 |
0.724 |
|
| 2001 |
Lakdawala A, Wang M, Nevins N, Liotta DC, Rusinska-Roszak D, Lozynski M, Snyder JP. Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study). Bmc Chemical Biology. 1: 2. PMID 11710970 DOI: 10.1186/1472-6769-1-2 |
0.728 |
|
| 2001 |
Nicolaou KC, Namoto K, Ritzén A, Ulven T, Shoji M, Li J, D'Amico G, Liotta D, French CT, Wartmann M, Altmann KH, Giannakakou P. Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues. Journal of the American Chemical Society. 123: 9313-23. PMID 11562214 DOI: 10.1021/Ja011338B |
0.321 |
|
| 2001 |
Judd DA, Nettles JH, Nevins N, Snyder JP, Liotta DC, Tang J, Ermolieff J, Schinazi RF, Hill CL. Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition Journal of the American Chemical Society. 123: 886-897. PMID 11456622 DOI: 10.1021/Ja001809E |
0.728 |
|
| 2001 |
Venkatesan H, Davis MC, Altas Y, Snyder JP, Liotta DC. Total synthesis of SR 121463 A, a highly potent and selective vasopressin V2 receptor antagonist Journal of Organic Chemistry. 66: 3653-3661. PMID 11374981 DOI: 10.1021/Jo0004658 |
0.539 |
|
| 2001 |
Lakdawala A, Wang M, Nevins N, Liotta DC, Rusinska-Roszak D, Lozynski M, Snyder JP. Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study) Bmc Chemical Biology. 1: 1-8. DOI: 10.1186/1472-6769-1-1 |
0.7 |
|
| 2000 |
Wang M, Cornett B, Nettles J, Liotta DC, Snyder JP. The oxetane ring in Taxol Journal of Organic Chemistry. 65: 1059-1068. PMID 10814054 DOI: 10.1021/Jo9916075 |
0.757 |
|
| 2000 |
Curfman C, Liotta D. Synthesis of sphingosine and sphingoid bases. Methods in Enzymology. 311: 391-440. PMID 10563342 DOI: 10.1016/S0076-6879(00)11098-5 |
0.791 |
|
| 1999 |
Wang M, Xia X, Kim Y, Hwang D, Jansen JM, Botta M, Liotta DC, Snyder JP. A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone Organic Letters. 1: 43-46. PMID 10822530 DOI: 10.1021/Ol990521V |
0.453 |
|
| 1999 |
Bushnev AS, Liotta DC. Practical synthesis of N-palmitoylsphingomyelin and N- palmitoyldihydrosphingomyelin Methods in Enzymology. 311: 535-547. PMID 10563348 DOI: 10.1016/S0076-6879(00)11104-8 |
0.349 |
|
| 1999 |
Shi J, McAtee JJ, Wirtz SS, Tharnish P, Juodawlkis A, Liotta DC, Schinazi RF. Synthesis and biological evaluation of 2',3'-didehydro-2',3'-dideoxy-5- fluorocytidine (D4FC) analogues: Discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase Journal of Medicinal Chemistry. 42: 859-867. PMID 10072683 DOI: 10.1021/Jm980510S |
0.306 |
|
| 1998 |
Birt DF, Merrill AH, Barnett T, Enkvetchakul B, Pour PM, Liotta DC, Geisler V, Menaldino DS, Schwartzbauer J. Inhibition of skin carcinomas but not papillomas by sphingosine, N- methylsphingosine, and N-acetylsphingosine Nutrition and Cancer. 31: 119-126. PMID 9770723 DOI: 10.1080/01635589809514690 |
0.306 |
|
| 1998 |
Humpf HU, Schmelz EM, Meredith FI, Vesper H, Vales TR, Wang E, Menaldino DS, Liotta DC, Merrill AH. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase: Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor Journal of Biological Chemistry. 273: 19060-19064. PMID 9668088 DOI: 10.1074/Jbc.273.30.19060 |
0.329 |
|
| 1997 |
Goudgaon NM, El-Kattan YA, Xia X, McAtee J, Soria J, Wey SJ, Liotta DC, Schinazi RF. A general synthetic method of 5-carboranyluracil nucleosides with potential antiviral activity and use in neutron capture therapy Nucleosides and Nucleotides. 16: 2133-2150. DOI: 10.1080/07328319708002564 |
0.306 |
|
| 1996 |
Merrill AH, Liotta DC, Riley RT. Sphingolipids as regulators of cellular growth, differentiation, and behavior Advances in Lipobiology. 1: 273-298. DOI: 10.1016/S1874-5245(96)80012-7 |
0.311 |
|
| 1995 |
Pushkareva M, Chao R, Bielawska A, Merrill AH, Crane HM, Lagu B, Liotta D, Hannun YA. Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry. 34: 1885-92. PMID 7849048 DOI: 10.1021/Bi00006A009 |
0.306 |
|
| 1995 |
Hoekstra WJ, Beavers MP, Andrade-Gordon P, Evangelisto MF, Keane PM, Press JB, Tomko KA, Fan F, Kloczewiak M, Mayo KH, Durkin KA, Liotta DC. Design and evaluation of nonpeptide fibrinogen γ-chain based GPIIb/IIIa antagonists Journal of Medicinal Chemistry. 38: 1582-1592. PMID 7752183 DOI: 10.1021/Jm00010A002 |
0.331 |
|
| 1994 |
Schinazi RF, Goudgaon NM, Fulcrand G, el Kattan Y, Lesnikowski Z, Ullas G, Moravek J, Liotta DC. Cellular pharmacology and biological activity of 5-carboranyl-2'-deoxyuridine. International Journal of Radiation Oncology, Biology, Physics. 28: 1113-20. PMID 8175396 DOI: 10.1016/0360-3016(94)90485-5 |
0.305 |
|
| 1992 |
Schinazi RF, Boudinot FD, Ibrahim SS, Manning C, McClure HM, Liotta DC. Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys. Antimicrobial Agents and Chemotherapy. 36: 2432-8. PMID 1336946 DOI: 10.1128/Aac.36.11.2432 |
0.302 |
|
| 1990 |
Greenberg P, Merrill AH, Liotta DC, Grabowski GA. Human acid beta-glucosidase: use of sphingosyl and N-alkyl-glucosylamine inhibitors to investigate the properties of the active site. Biochimica Et Biophysica Acta. 1039: 12-20. PMID 2141287 DOI: 10.1016/0167-4838(90)90220-A |
0.301 |
|
| 1988 |
Dunams T, Hoekstra W, Pentaleri M, Liotta D. Molecular aggregation and its applicability to synthesis. The Diels-Alder reaction Tetrahedron Letters. 29: 3745-3748. DOI: 10.1016/S0040-4039(00)82104-8 |
0.758 |
|
| 1985 |
Gupton JT, Hertel G, DeCrescenzo G, Colon C, Baran D, Dukesherer D, Novick S, Liotta D, Idoux JP. Regioselective fluoroalkoxylation and polyfluoroalkoxylation of aromatic and heteroaromatic polyhalides Canadian Journal of Chemistry. 63: 3037-3042. DOI: 10.1139/V85-504 |
0.324 |
|
| 1979 |
Zima G, Liotta D. A General Synthesis of 2-Phenylselenenylenones. The Reaction of Unsaturated Ketones with a Phenylselenenyl Chloride/Pyridine Complex Synthetic Communications. 9: 697-703. DOI: 10.1080/00397917908064181 |
0.315 |
|
| 1978 |
Baker AD, Wong D, Lo S, Bloch M, Horozoglu G, Goldman NL, Engel R, Liotta DC. The reaction of N-aryl nitrones with dichloroketene: A new synthesis of isatins Tetrahedron Letters. 19: 219-222. DOI: 10.1016/S0040-4039(01)85088-7 |
0.503 |
|
| 1976 |
Paquette LA, Liotta DC, Liao CC, Wallis TG, Eickman N, Clardy J, Gleiter R. Endoperoxidation of conformationally fixed norcaradienes by singlet oxygen. Frontier molecular orbital basis for the operability of 1O2 quenching by hydrazides Journal of the American Chemical Society. 98: 6413-6416. DOI: 10.1021/Ja00436A072 |
0.334 |
|
| 1976 |
Paquette LA, Liao CC, Liotta DC, Fristad WE. Reversal Of Stereospecificity During Allylic Hydroperoxidation Of 3-Norcarene And Bicyclo(4.2.0)Oct-3-Ene Derivatives Arising From Structurally Enforced Quenching Of Singlet Oxygen By The Hydrazide Functionality Journal of the American Chemical Society. 98: 6412-6413. DOI: 10.1021/Ja00436A071 |
0.381 |
|
| 1976 |
Paquette LA, Liotta DC, Baker AD. Frontier molecular orbital basis for the structurally dependent regiospecific reactions of singlet (1Δg) oxygen with polyolefins Tetrahedron Letters. 17: 2681-2684. DOI: 10.1016/S0040-4039(00)77794-X |
0.367 |
|
| 1975 |
Liotta D, Engel R. The Thermal Decomposition of Alkoxycarbonyl Thiocyanates and Isothiocyanates Canadian Journal of Chemistry. 53: 907-912. DOI: 10.1002/Chin.197526200 |
0.468 |
|
| 1974 |
Liotta D, Baker AD, Goldstein S, Goldman NL, Weinstein-Lanse F, Felsen-Reingold D, Engel R. Reactions of N-aryl nitrogen oxides. 1. Selective ortho chlorination in the reactions of aryl nitrones and amine oxides with thionyl chloride or phosgene The Journal of Organic Chemistry. 39: 2718-2722. DOI: 10.1021/Jo00932A011 |
0.486 |
|
| 1974 |
Liotta D, Baker AD, Goldman NL, Engel R. Reactions of N-aryl nitrogen oxides. 2. Reaction of N-aryl nitrones with oxalyl chloride The Journal of Organic Chemistry. 39: 1975-1976. DOI: 10.1021/Jo00927A052 |
0.48 |
|
| 1973 |
Liotta D, Baker AD, Weinstein F, Felsen D, Engel R, Goldman NL. Reaction of aryl nitrones with thionyl chloride or phosgene The Journal of Organic Chemistry. 38: 3445-3446. DOI: 10.1021/Jo00959A060 |
0.475 |
|
| 1970 |
Engel RR, Liotta D. Thermal decomposition of phosphorothioates Journal of the Chemical Society C: Organic. 523-524. DOI: 10.1039/J39700000523 |
0.47 |
|
| 1970 |
ENGEL RR, LIOTTA D. ChemInform Abstract: THERMISCHE ZERS. VON THIOPHOSPHORSAEUREESTERN Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/Chin.197021115 |
0.452 |
|
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