| Year |
Citation |
Score |
| 2013 |
Koch CP, Perna AM, Pillong M, Todoroff NK, Wrede P, Folkers G, Hiss JA, Schneider G. Scrutinizing MHC-I binding peptides and their limits of variation. Plos Computational Biology. 9: e1003088. PMID 23754940 DOI: 10.1371/Journal.Pcbi.1003088 |
0.305 |
|
| 2008 |
Michael M, Fetzer J, Folkers G. Site-Directed Mutagenesis Clarifies the Substrate Position within the Three-Dimensional Model of the Active Site of Herpes Simplex Virus Type-1 Thymidine Kinase European Journal of Biochemistry. 226: 219-226. DOI: 10.1111/J.1432-1033.1994.0T219.X |
0.312 |
|
| 2007 |
Iqbal J, Scapozza L, Folkers G, Müller CE. Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 846: 281-290. PMID 17023224 DOI: 10.1016/J.Jchromb.2006.09.018 |
0.462 |
|
| 2005 |
Kostrewa D, Winkler FK, Folkers G, Scapozza L, Perozzo R. The crystal structure of PfFabZ, the unique beta-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum. Protein Science : a Publication of the Protein Society. 14: 1570-80. PMID 15930004 DOI: 10.1110/Ps.051373005 |
0.304 |
|
| 2005 |
Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L. Structure of a type II thymidine kinase with bound dTTP Febs Letters. 579: 1376-1382. PMID 15733844 DOI: 10.1016/J.Febslet.2005.01.034 |
0.31 |
|
| 2005 |
Scapozza L, Rognan D, Folkers G, Daser A. Molecular dynamics and structure-based drug design for predicting non-natural nonapeptide binding to a class I MHC protein. Acta Crystallographica. Section D, Biological Crystallography. 51: 541-9. PMID 15299842 DOI: 10.1107/S0907444995002678 |
0.341 |
|
| 2004 |
Perozzo R, Folkers G, Scapozza L. Thermodynamics of protein-ligand interactions: History, presence, and future aspects Journal of Receptors and Signal Transduction. 24: 1-52. PMID 15344878 DOI: 10.1081/Rrs-120037896 |
0.32 |
|
| 2004 |
Cavalli A, Prota AE, Stehle T, Dermody TS, Recanatini M, Folkers G, Scapozza L. A molecular dynamics study of reovirus attachment protein sigma1 reveals conformational changes in sigma1 structure. Biophysical Journal. 86: 3423-31. PMID 15189844 DOI: 10.1529/Biophysj.103.030825 |
0.321 |
|
| 2004 |
Folkers G. Pharmaceutical Chemistry at the ETH Zürich Chimia. 58: 707-710. DOI: 10.2533/000942904777677362 |
0.327 |
|
| 2003 |
Russ P, Schelling P, Scapozza L, Folkers G, Clercq ED, Marquez VE. Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine. Journal of Medicinal Chemistry. 46: 5045-54. PMID 14584954 DOI: 10.1021/Jm030241S |
0.305 |
|
| 2003 |
Klein CD, Schiffmann R, Folkers G, Piana S, Röthlisberger U. Protonation states of methionine aminopeptidase and their relevance for inhibitor binding and catalytic activity. The Journal of Biological Chemistry. 278: 47862-7. PMID 14514693 DOI: 10.1074/Jbc.M305325200 |
0.307 |
|
| 2003 |
Spadola L, Novellino E, Folkers G, Scapozza L. Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase. European Journal of Medicinal Chemistry. 38: 413-9. PMID 12750029 DOI: 10.1016/S0223-5234(03)00053-9 |
0.31 |
|
| 2002 |
Pospisil P, Kuoni T, Scapozza L, Folkers G. Methodology and problems of protein-ligand docking: case study of dihydroorotate dehydrogenase, thymidine kinase, and phosphodiesterase 4. Journal of Receptor and Signal Transduction Research. 22: 141-54. PMID 12503612 DOI: 10.1081/Rrs-120014592 |
0.324 |
|
| 2002 |
Lerch M, Gafner V, Bader R, Christen B, Folkers G, Zerbe O. Bovine pancreatic polypeptide (bPP) undergoes significant changes in conformation and dynamics upon binding to DPC micelles. Journal of Molecular Biology. 322: 1117-33. PMID 12367532 DOI: 10.1016/S0022-2836(02)00889-6 |
0.303 |
|
| 2002 |
Pospisil P, Pilger BD, Marveggio S, Schelling P, Wurth C, Scapozza L, Folkers G, Pongracic M, Mintas M, Malic SR. Synthesis, kinetics, and molecular docking of novel 9-(2-hydroxypropyl)purine nucleoside analogs as ligands of herpesviral thymidine kinases Helvetica Chimica Acta. 85: 3237-3250. DOI: 10.1002/1522-2675(200210)85:10<3237::Aid-Hlca3237>3.0.Co;2-3 |
0.348 |
|
| 2001 |
Cavalli A, Dezi C, Folkers G, Scapozza L, Recanatini M. Three-dimensional model of the cyclin-dependent kinase 1 (CDK1): Ab initio active site parameters for molecular dynamics studies of CDKs Proteins: Structure, Function and Genetics. 45: 478-485. PMID 11746695 DOI: 10.1002/Prot.10013 |
0.313 |
|
| 2001 |
Demuth C, Zerbe O, Rognan D, Söll R, Beck-Sickinger A, Folkers G, Spichiger UE. A rationally designed oligopeptide shows significant conformational changes upon binding to sulphate ions Biosensors and Bioelectronics. 16: 783-789. PMID 11679256 DOI: 10.1016/S0956-5663(01)00221-4 |
0.323 |
|
| 2001 |
Rognan D, Mukhija S, Folkers G, Zerbe O. NMR-restrained docking of a peptidic inhibitor to the N-terminal domain of the phosphoenolpyruvate: Sugar phosphotransferase enzyme I Journal of Computer-Aided Molecular Design. 15: 103-115. PMID 11272698 DOI: 10.1023/A:1008145813315 |
0.344 |
|
| 2001 |
Wurth C, Kessler U, Vogt J, Schulz GE, Folkers G, Scapozza L. The effect of substrate binding on the conformation and structural stability of Herpes simplex virus type 1 thymidine kinase Protein Science. 10: 63-73. PMID 11266595 DOI: 10.1110/Ps.27401 |
0.325 |
|
| 2001 |
Sulpizi M, Schelling P, Folkers G, Carloni P, Scapozza L. The rational of catalytic activity of herpes simplex virus thymidine kinase. A combined biochemical and quantum chemical study Journal of Biological Chemistry. 276: 21692-21697. PMID 11262392 DOI: 10.1074/Jbc.M010223200 |
0.316 |
|
| 2000 |
Vogt J, Perozzo R, Pautsch A, Prota A, Schelling P, Pilger B, Folkers G, Scapozza L, Schulz GE. Nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography Proteins: Structure, Function and Genetics. 41: 545-553. PMID 11056041 DOI: 10.1002/1097-0134(20001201)41:4<545::Aid-Prot110>3.0.Co;2-8 |
0.333 |
|
| 2000 |
Prota A, Vogt J, Pilger B, Perozzo R, Wurth C, Marquez VE, Russ P, Schulz GE, Folkers G, Scapozza L. Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine Biochemistry. 39: 9597-9603. PMID 10924157 DOI: 10.2210/Pdb1E2K/Pdb |
0.301 |
|
| 2000 |
Perozzo R, Jelesarov I, Bosshard HR, Folkers G, Scapozza L. Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase: A calorimetric study Journal of Biological Chemistry. 275: 16139-16145. PMID 10747922 DOI: 10.1074/Jbc.M000509200 |
0.303 |
|
| 1999 |
Pilger BD, Perozzo R, Alber F, Wurth C, Folkers G, Scapozza L. Substrate diversity of herpes simplex virus thymidine kinase. Impact of the kinematics of the enzyme Journal of Biological Chemistry. 274: 31967-31973. PMID 10542226 DOI: 10.1074/Jbc.274.45.31967 |
0.319 |
|
| 1999 |
Poenaru S, Lamas JR, Folkers G, López de Castro JA, Seebach D, Rognan D. Nonapeptide analogues containing (R)-3-hydroxybutanoate and beta-homoalanine oligomers: synthesis and binding affinity to a class I major histocompatibility complex protein. Journal of Medicinal Chemistry. 42: 2318-31. PMID 10395472 DOI: 10.1021/Jm981123L |
0.33 |
|
| 1999 |
Kussmann-Gerber S, Wurth C, Scapozza L, Pilger BD, Pliška V, Folkers G. Interaction of the recombinant Herpes Simplex Virus type 1 thymidine kinase with thymidine and aciclovir: A kinetic study Nucleosides and Nucleotides. 18: 311-330. PMID 10358938 DOI: 10.1080/15257779908043078 |
0.315 |
|
| 1999 |
Dédier S, Krebs S, Lamas JR, Poenaru S, Folkers G, López de Castro JA, Seebach D, Rognan D. Structure-based design of nonnatural ligands for the HLA-B27 protein. Journal of Receptor and Signal Transduction Research. 19: 645-57. PMID 10071790 DOI: 10.3109/10799899909036677 |
0.332 |
|
| 1999 |
Krebs S, Folkers G, Rognan D. Binding of rationally designed non-natural peptides to the human leukocyte antigen HLA-B*2705. Journal of Peptide Science : An Official Publication of the European Peptide Society. 4: 378-88. PMID 9796857 DOI: 10.1002/(Sici)1099-1387(199809)4:6<378::Aid-Psc157>3.0.Co;2-B |
0.326 |
|
| 1998 |
Kussmann-Gerber S, Kuonen O, Folkers G, Pilger BD, Scapozza L. Drug resistance of herpes simplex virus type 1--structural considerations at the molecular level of the thymidine kinase. European Journal of Biochemistry. 255: 472-81. PMID 9716390 DOI: 10.1046/J.1432-1327.1998.2550472.X |
0.342 |
|
| 1998 |
Krebs S, Lamas JR, Poenaru S, Folkers G, de Castro JA, Seebach D, Rognan D. Substituting nonpeptidic spacers for the T cell receptor-binding part of class I major histocompatibility complex-binding peptides. The Journal of Biological Chemistry. 273: 19072-9. PMID 9668090 DOI: 10.1074/Jbc.273.30.19072 |
0.329 |
|
| 1998 |
Alber F, Kuonen O, Scapozza L, Folkers G, Carloni P. Density functional studies on herpes simplex virus type 1 thymidine kinase-substrate interactions: the role of Tyr-172 and Met-128 in thymine fixation. Proteins. 31: 453-9. PMID 9626704 DOI: 10.1002/(Sici)1097-0134(19980601)31:4<453::Aid-Prot11>3.0.Co;2-E |
0.306 |
|
| 1998 |
Wild K, Bohner T, Folkers G, Schulz GE. The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue. Protein Science : a Publication of the Protein Society. 6: 2097-106. PMID 9336833 DOI: 10.1002/Pro.5560061005 |
0.339 |
|
| 1998 |
Seebach D, Poenaru S, Folkers G, Rognan D. Synthesis of Oligo(3-hydroxybutanoate)(OHB)-Containing Peptides with High Binding Affinity to a Class-I-MHC Protein Helvetica Chimica Acta. 81: 1181-1200. DOI: 10.1002/Hlca.19980810529 |
0.326 |
|
| 1998 |
Zbinden P, Dobler M, Folkers G, Vedani A. PrGen: Pseudoreceptor Modeling Using Receptor‐mediated Ligand Alignment and Pharmacophore Equilibration Quantitative Structure-Activity Relationships. 17: 122-130. DOI: 10.1002/(Sici)1521-3838(199804)17:02<122::Aid-Qsar122>3.3.Co;2-C |
0.302 |
|
| 1997 |
Rognan D, Krebs S, Kuonen O, Lamas JR, López de Castro JA, Folkers G. Fine specificity of antigen binding to two class I major histocompatibility proteins (B*2705 and B*2703) differing in a single amino acid residue. Journal of Computer-Aided Molecular Design. 11: 463-78. PMID 9385550 DOI: 10.1023/A:1007963901092 |
0.311 |
|
| 1997 |
Folkers G, Alber F, Amrhein I, Behrends H, Bohner T, Gerber S, Kuonen O, Scapozza L. Integrated homology modelling and X-ray study of herpes simplex virus I thymidine kinase: a case study. Journal of Receptor and Signal Transduction Research. 17: 475-94. PMID 9029509 DOI: 10.3109/10799899709036622 |
0.331 |
|
| 1996 |
Kern P, Brunne RM, Rognan D, Folkers G. A pseudo-particle approach for studying protein-ligand models truncated to their active sites. Biopolymers. 38: 619-37. PMID 8722231 DOI: 10.1002/(Sici)1097-0282(199605)38:5<619::Aid-Bip7>3.0.Co;2-V |
0.324 |
|
| 1995 |
Greenidge PA, Merz A, Folkers G. A pseudoreceptor modelling study of the varicella-zoster virus and human thymidine kinase binding sites. Journal of Computer-Aided Molecular Design. 9: 473-8. PMID 8789189 DOI: 10.1007/Bf00124318 |
0.326 |
|
| 1995 |
Rognan D, Scapozza L, Folkers G, Daser A. Rational design of nonnatural peptides as high-affinity ligands for the HLA-B*2705 human leukocyte antigen. Proceedings of the National Academy of Sciences of the United States of America. 92: 753-7. PMID 7846047 DOI: 10.1073/Pnas.92.3.753 |
0.319 |
|
| 1995 |
Fetzer J, Michael M, Bohner T, Hofbauer R, Folkers G. A fast method for obtaining highly pure recombinant herpes simplex virus type 1 thymidine kinase. Protein Expression and Purification. 5: 432-41. PMID 7827501 DOI: 10.1006/Prep.1994.1062 |
0.315 |
|
| 1995 |
Kern P, Brunne RM, Folkers G. Nucleotide-binding properties of adenylate kinase from Escherichia coli: a molecular dynamics study in aqueous and vacuum environments. Journal of Computer-Aided Molecular Design. 8: 367-88. PMID 7815090 DOI: 10.1007/Bf00125373 |
0.321 |
|
| 1995 |
Beck-Sickinger AG, Kiess M, Kern P, Folkers G. Secondary structure prediction of adenylate kinase by circular dichroism spectroscopy of synthetic peptides. Pharmaceutica Acta Helvetiae. 70: 33-41. PMID 7770476 DOI: 10.1016/0031-6865(94)00049-2 |
0.301 |
|
| 1994 |
Rognan D, Scapozza L, Folkers G, Daser A. Molecular dynamics simulation of MHC-peptide complexes as a tool for predicting potential T cell epitopes. Biochemistry. 33: 11476-85. PMID 7522551 DOI: 10.1021/Bi00204A009 |
0.332 |
|
| 1993 |
Fetzer J, Folkers G, Müller I, Keil GM. Site-directed mutagenesis in the active site of the herpes simplex virus type 1 thymidine kinase gene. Virus Genes. 7: 205-9. PMID 8396286 DOI: 10.1007/Bf01702400 |
0.306 |
|
| 1992 |
Folkers G, Trumpp-Kallmeyer S, Gutbrod O, Krickl S, Fetzer J, Keil GM. Computer-aided active-site-directed modeling of the herpes simplex virus 1 and human thymidine kinase. Journal of Computer-Aided Molecular Design. 5: 385-404. PMID 1663155 DOI: 10.1007/Bf00125660 |
0.351 |
|
| 1992 |
Rognan D, Reddehase MJ, Koszinowski UH, Folkers G. Molecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein. Proteins. 13: 70-85. PMID 1594579 DOI: 10.1002/Prot.340130107 |
0.33 |
|
| 1992 |
Rognan D, Zimmermann N, Jung G, Folkers G. Molecular dynamics study of a complex between the human histocompatibility antigen HLA-A2 and the IMP58-66 nonapeptide from influenza virus matrix protein. European Journal of Biochemistry. 208: 101-13. PMID 1511679 DOI: 10.1111/J.1432-1033.1992.Tb17163.X |
0.318 |
|
| 1991 |
Zimmermann N, Beck-Sickinger AG, Folkers G, Krickl S, Müller I, Jung G. Conformational and epitope mapping of herpes-simplex-virus type-1 thymidine kinase using synthetic peptide segments. European Journal of Biochemistry. 200: 519-28. PMID 1716203 DOI: 10.1111/J.1432-1033.1991.Tb16213.X |
0.303 |
|
| 1989 |
Folkers G, Krickl S, Trumpp S. [Localization of the essential structure for binding of antiviral agents to thymidine kinase by studying sequence homologies]. Archiv Der Pharmazie. 322: 409-13. PMID 2783014 DOI: 10.1002/Ardp.19893220706 |
0.317 |
|
| 1989 |
Folkers G, Sakahara K, Schwöbel W, Eger K. [The development of pharmacophore models for thymidine kinase-dependent virostatic nucleoside analogs]. Archiv Der Pharmazie. 322: 395-8. PMID 2783012 DOI: 10.1002/Ardp.19893220703 |
0.341 |
|
| 1989 |
Folkers G, Junginger G, Müller CE, Schloz U, Eger K. [Synthesis of computer graphic calculated high-anti-fixed pyrimidine nucleoside analogs with potential virostatic and antineoplastic action]. Archiv Der Pharmazie. 322: 119-23. PMID 2730290 DOI: 10.1002/Ardp.19893220213 |
0.447 |
|
| 1989 |
Müller CE, Folkers G. [Adenosine receptor ligands--drugs of the future?]. Pharmazie in Unserer Zeit. 18: 65-75. PMID 2657803 DOI: 10.1002/Pauz.19890180302 |
0.435 |
|
| 1987 |
Eger K, Pfahl JG, Folkers G, Roth HJ. Selected reactions on the o-aminonitrile system of substituted pyrroles Journal of Heterocyclic Chemistry. 24: 425-430. DOI: 10.1002/Jhet.5570240224 |
0.49 |
|
| 1986 |
Folkers G, Roth HJ. [The synthesis of potential 5-lipoxygenase inhibitors. 1]. Archiv Der Pharmazie. 319: 530-7. PMID 3090976 DOI: 10.1002/Ardp.19863190610 |
0.519 |
|
| 1985 |
Folkers G, Roth HJ. Ein Weg zu N-1-heterocyclisch substituierten 5-Nitrobenzimidazolen Archiv Der Pharmazie. 318: 953-954. DOI: 10.1002/Ardp.19853181018 |
0.492 |
|
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