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Colin R. Jefcoate, D. Phil. - Publications

Pharmacology University of Wisconsin, Madison, Madison, WI 
Cytochromes P450, xenobiotic metabolism, steroidogenesis

223 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kothandapani A, Larsen MC, Lee J, Jorgensen JS, Jefcoate CR. Distinctive functioning of STARD1 in the fetal Leydig cells compared to adult Leydig and adrenal cells. Impact of Hedgehog signaling via the primary cilium. Molecular and Cellular Endocrinology. 111265. PMID 33864885 DOI: 10.1016/j.mce.2021.111265  1
2021 Kothandapani A, Jefcoate CR, Jorgensen JS. Cholesterol contributes to male sex differentiation through its developmental role in androgen synthesis and hedgehog signaling. Endocrinology. PMID 33784378 DOI: 10.1210/endocr/bqab066  0.32
2020 Larsen MC, Lee J, Jorgensen JS, Jefcoate CR. STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association. Frontiers in Endocrinology. 11: 559674. PMID 33193082 DOI: 10.3389/fendo.2020.559674  1
2020 Larsen MC, Almeldin A, Tong T, Rondelli CM, Maguire M, Jaskula-Sztul R, Jefcoate CR. Cytochrome P4501B1 in bone marrow is co-expressed with key markers of mesenchymal stem cells. BMS2 cell line models PAH disruption of bone marrow niche development functions. Toxicology and Applied Pharmacology. 115111. PMID 32553695 DOI: 10.1016/J.Taap.2020.115111  0.76
2020 Maguire M, Larsen MC, Vezina CM, Quadro L, Kim YK, Tanumihardjo SA, Jefcoate CR. Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development. Plos One. 15: e0228436. PMID 32027669 DOI: 10.1371/Journal.Pone.0228436  0.4
2019 Falero-Perez J, Larsen MC, Teixeira LBC, Zhang HF, Lindner V, Sorenson CM, Jefcoate CR, Sheibani N. Targeted deletion of Cyp1b1 in pericytes results in attenuation of retinal neovascularization and trabecular meshwork dysgenesis. Trends in Developmental Biology. 12: 1-12. PMID 32255961  0.4
2019 Day JH, Nicholson TM, Su X, van Neel TL, Clinton I, Kothandapani A, Lee J, Greenberg MH, Amory JK, Walsh TJ, Muller CH, Franco OE, Jefcoate CR, Crawford SE, Jorgensen JS, et al. Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy. Lab On a Chip. PMID 31712791 DOI: 10.1039/C9Lc00706G  1
2019 Ostrem Loss EM, Lee MK, Wu MY, Martien J, Chen W, Amador-Noguez D, Jefcoate C, Remucal C, Jung S, Kim SC, Yu JH. Cytochrome P450 Monooxygenase-Mediated Metabolic Utilization of Benzo[]Pyrene by Species. Mbio. 10. PMID 31138742 DOI: 10.1128/Mbio.00558-19  0.64
2019 Jefcoate CR, Larsen MC. StAR, a bridge from ApoE, LDL, and HDL cholesterol trafficking to mitochondrial metabolism Current Opinion in Endocrine and Metabolic Research. 8: 195-205. DOI: 10.1016/J.Coemr.2019.07.011  0.4
2018 Jefcoate CR, Lee J. Cholesterol signaling in single cells: lessons from STAR and sm-FISH. Journal of Molecular Endocrinology. 60: R213-R235. PMID 29691317 DOI: 10.1530/Jme-17-0281  1
2017 Lee J, Jefcoate C. Monitoring of Dual CRISPR/Cas9-Mediated Steroidogenic Acute Regulatory Protein Gene Deletion and Cholesterol Accumulation Using High-Resolution Fluorescence In Situ Hybridization in a Single Cell. Frontiers in Endocrinology. 8: 289. PMID 29118738 DOI: 10.3389/Fendo.2017.00289  1
2017 Maguire M, Larsen MC, Foong YH, Tanumihardjo S, Jefcoate CR. Cyp1b1 deletion and retinol deficiency coordinately suppress mouse liver lipogenic genes and hepcidin expression during post-natal development. Molecular and Cellular Endocrinology. PMID 28583802 DOI: 10.1016/J.Mce.2017.05.037  0.76
2017 Maguire M, Bushkofsky JR, Larsen MC, Foong YH, Tanumihardjo SA, Jefcoate CR. Diet-dependent retinoid effects on liver gene expression include stellate and inflammation markers and parallel effects of the nuclear repressor Shp. The Journal of Nutritional Biochemistry. 47: 63-74. PMID 28570941 DOI: 10.1016/J.Jnutbio.2017.04.009  0.76
2016 Larsen MC, N'Jai AU, Alexander DL, Rondelli CM, Forsberg EC, Czuprynski CJ, Jefcoate CR. Cyp1b1-mediated suppression of lymphoid progenitors in bone marrow by polycyclic aromatic hydrocarbons coordinately impacts spleen and thymus: a selective role for the Ah Receptor. Pharmacology Research & Perspectives. 4: e00245. PMID 28116098 DOI: 10.1002/Prp2.245  0.4
2016 Rondelli CM, Larsen MC, N'jai A, Czuprynski CJ, Jefcoate CR. PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model. Stem Cells International. 2016: 1753491. PMID 27891153 DOI: 10.1155/2016/1753491  0.4
2016 Lee J, Tong T, Duan H, Foong YH, Musaitif I, Yamazaki T, Jefcoate C. Regulation of StAR by the N-terminal Domain and Coinduction of SIK1 and TIS11b/Znf36l1 in Single Cells. Frontiers in Endocrinology. 7: 107. PMID 27531991 DOI: 10.3389/Fendo.2016.00107  1
2016 Lee J, Yamazaki T, Dong H, Jefcoate C. A single cell level measurement of StAR expression and activity in adrenal cells. Molecular and Cellular Endocrinology. PMID 27521960 DOI: 10.1016/J.Mce.2016.08.015  1
2016 Kim SH, Trinh AT, Larsen MC, Mastrocola AS, Jefcoate CR, Bushel PR, Tibbetts RS. Tunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism. Nucleic Acids Research. PMID 27431323 DOI: 10.1093/Nar/Gkw643  0.4
2016 Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury. Biochemical and Biophysical Research Communications. PMID 27235555 DOI: 10.1016/J.Bbrc.2016.05.125  1
2016 Lee J, Foong YH, Musaitif I, Tong T, Jefcoate C. Analysis of specific RNA in cultured cells through quantitative integration of q-PCR and N-SIM single cell FISH images: Application to hormonal stimulation of StAR transcription. Molecular and Cellular Endocrinology. PMID 27091298 DOI: 10.1016/J.Mce.2016.04.001  1
2016 Bushkofsky JR, Maguire M, Larsen MC, Fong YH, Jefcoate CR. Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4α and PPARα. Archives of Biochemistry and Biophysics. PMID 27036855 DOI: 10.1016/J.Abb.2016.03.030  1
2015 Larsen MC, Bushkofsky JR, Gorman T, Adhami V, Mukhtar H, Wang S, Reeder SB, Sheibani N, Jefcoate CR. Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasis. Archives of Biochemistry and Biophysics. 571: 21-39. PMID 25703193 DOI: 10.1016/J.Abb.2015.02.010  1
2015 Lee J, Tong T, Takemori H, Jefcoate C. Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB. Molecular and Cellular Endocrinology. 408: 80-9. PMID 25662274 DOI: 10.1016/J.Mce.2015.01.022  1
2014 Chen W, Lee MK, Jefcoate C, Kim SC, Chen F, Yu JH. Fungal cytochrome p450 monooxygenases: their distribution, structure, functions, family expansion, and evolutionary origin. Genome Biology and Evolution. 6: 1620-34. PMID 24966179 DOI: 10.1093/Gbe/Evu132  1
2014 Li F, Jiang C, Larsen MC, Bushkofsky J, Krausz KW, Wang T, Jefcoate CR, Gonzalez FJ. Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity. Journal of Proteome Research. 13: 2679-87. PMID 24684199 DOI: 10.1021/Pr500145N  1
2013 Piccinato CA, Rosa GJM, N'Jai AU, Jefcoate CR, Wiltbank MC. Estradiol and Progesterone Exhibit Similar Patterns of Hepatic Gene Expression Regulation in the Bovine Model Plos One. 8. PMID 24069207 DOI: 10.1371/Journal.Pone.0073552  1
2013 Zhao Y, Wang S, Sorenson CM, Teixeira L, Dubielzig RR, Peters DM, Conway SJ, Jefcoate CR, Sheibani N. Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress. Molecular and Cellular Biology. 33: 4225-40. PMID 23979599 DOI: 10.1128/Mcb.00856-13  1
2013 Dong H, Shertzer HG, Genter MB, Gonzalez FJ, Vasiliou V, Jefcoate C, Nebert DW. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochemical and Biophysical Research Communications. 435: 727-32. PMID 23692925 DOI: 10.1016/J.Bbrc.2013.05.051  1
2013 Palenski TL, Sorenson CM, Jefcoate CR, Sheibani N. Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells Laboratory Investigation. 93: 646-662. PMID 23568032 DOI: 10.1038/Labinvest.2013.55  1
2013 Zheng W, Tong T, Lee J, Liu X, Marcus C, Jefcoate CR. Stimulation of mouse Cyp1b1 during adipogenesis: characterization of promoter activation by the transcription factor Pax6. Archives of Biochemistry and Biophysics. 532: 1-14. PMID 23376040 DOI: 10.1016/J.Abb.2013.01.007  1
2012 Feng J, Zhao L, Liu X, Jefcoate CR, Wang S. Role of white adipose tissue in protecting CYP1B1 knock-out mice from obesity Medical Journal of Wuhan University. 33: 503-506.  1
2011 N'jai AU, Larsen MC, Bushkofsky JR, Czuprynski CJ, Jefcoate CR. Acute disruption of bone marrow hematopoiesis by benzo(a)pyrene is selectively reversed by aryl hydrocarbon receptor-mediated processes. Molecular Pharmacology. 79: 724-34. PMID 21252291 DOI: 10.1124/Mol.110.070631  1
2011 Jefcoate CR, Lee J, Cherradi N, Takemori H, Duan H. cAMP stimulation of StAR expression and cholesterol metabolism is modulated by co-expression of labile suppressors of transcription and mRNA turnover. Molecular and Cellular Endocrinology. 336: 53-62. PMID 21147196 DOI: 10.1016/J.Mce.2010.12.006  1
2010 N'jai AU, Larsen M, Shi L, Jefcoate CR, Czuprynski CJ. Bone marrow lymphoid and myeloid progenitor cells are suppressed in 7,12-dimethylbenz(a)anthracene (DMBA) treated mice Toxicology. 271: 27-35. PMID 20171256 DOI: 10.1016/J.Tox.2010.02.009  1
2010 Tang Y, Scheef EA, Gurel Z, Sorenson CM, Jefcoate CR, Sheibani N. CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress American Journal of Physiology - Cell Physiology. 298: C665-C678. PMID 20032512 DOI: 10.1152/Ajpcell.00153.2009  1
2009 Duan H, Cherradi N, Feige JJ, Jefcoate C. cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b. Molecular Endocrinology (Baltimore, Md.). 23: 497-509. PMID 19179481 DOI: 10.1210/Me.2008-0296  1
2009 Tang Y, Scheef EA, Wang S, Sorenson CM, Marcus CB, Jefcoate CR, Sheibani N. CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression. Blood. 113: 744-54. PMID 19005183 DOI: 10.1182/Blood-2008-03-145219  1
2008 Halberg RB, Larsen MC, Elmergreen TL, Ko AY, Irving AA, Clipson L, Jefcoate CR. Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates. Cancer Research. 68: 7394-402. PMID 18794127 DOI: 10.1158/0008-5472.Can-07-6750  1
2008 Jefcoate CR, Wang S, Liu X. Methods that resolve different contributions of clonal expansion to adipogenesis in 3T3-L1 and C3H10T1/2 cells. Methods in Molecular Biology (Clifton, N.J.). 456: 173-193. PMID 18516561 DOI: 10.1007/978-1-59745-245-8_13  1
2007 Duan H, Jefcoate CR. The predominant cAMP-stimulated 3 x 5 kb StAR mRNA contains specific sequence elements in the extended 3'UTR that confer high basal instability. Journal of Molecular Endocrinology. 38: 159-79. PMID 17242178 DOI: 10.1677/Jme.1.02153  1
2006 Yamazaki T, Matsuoka C, Gendou M, Izumi S, Zhao D, Artemenko I, Jefcoate CR, Kominami S. Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein Biochimica Et Biophysica Acta - Proteins and Proteomics. 1764: 1561-1567. PMID 17029976 DOI: 10.1016/J.Bbapap.2006.08.016  1
2006 Liu X, Jefcoate C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and epidermal growth factor cooperatively suppress peroxisome proliferator-activated receptor-γ1 stimulation and restore focal adhesion complexes during adipogenesis: Selective contributions of Src, Rho, and Erk distinguish these overlapping processes in C3H10T1/2 cells Molecular Pharmacology. 70: 1902-1915. PMID 16971554 DOI: 10.1124/Mol.106.026534  1
2006 Jefcoate CR. Liver X receptor opens a new gateway to StAR and to steroid hormones Journal of Clinical Investigation. 116: 1832-1835. PMID 16823483 DOI: 10.1172/Jci29160  1
2006 Tsuchiya Y, Nakajima M, Takagi S, Katoh M, Zheng W, Jefcoate CR, Yokoi T. Binding of steroidogenic factor-1 to the regulatory region might not be critical for transcriptional regulation of the human CYP1B1 gene Journal of Biochemistry. 139: 527-534. PMID 16567417 DOI: 10.1093/jb/mvj055  1
2006 Galván N, Page TJ, Czuprynski CJ, Jefcoate CR. Benzo(a)pyrene and 7,12-dimethylbenz(a)anthrecene differentially affect bone marrow cells of the lymphoid and myeloid lineages. Toxicology and Applied Pharmacology. 213: 105-16. PMID 16307768 DOI: 10.1016/J.Taap.2005.09.018  1
2005 Hanlon PR, Cimafranca MA, Liu X, Cho YC, Jefcoate CR. Microarray analysis of early adipogenesis in C3H10T1/2 cells: cooperative inhibitory effects of growth factors and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology. 207: 39-58. PMID 16054899 DOI: 10.1016/J.Taap.2004.12.004  1
2005 Zhao D, Duan H, Kim YC, Jefcoate CR. Rodent StAR mRNA is substantially regulated by control of mRNA stability through sites in the 3'-untranslated region and through coupling to ongoing transcription. The Journal of Steroid Biochemistry and Molecular Biology. 96: 155-73. PMID 16039847 DOI: 10.1016/J.Jsbmb.2005.02.011  1
2005 Cho YC, Zheng W, Yamamoto M, Liu X, Hanlon PR, Jefcoate CR. Differentiation of pluripotent C3H10T1/2 cells rapidly elevates CYP1B1 through a novel process that overcomes a loss of Ah Receptor. Archives of Biochemistry and Biophysics. 439: 139-53. PMID 15967407 DOI: 10.1016/J.Abb.2005.04.025  1
2005 Yuroff AS, Jefcoate CR, Czuprynski CJ. Close proximity, but not VLA-4-dependent adherence between pre-B cells and bone marrow stromal cells, is required for DMBA-induced apoptosis of pre-B cells in vitro Toxicology Letters. 156: 253-260. PMID 15737488 DOI: 10.1016/J.Toxlet.2004.11.015  1
2005 Zhao D, Xue H, Artemenko I, Jefcoate C. Novel signaling stimulated by arsenite increases cholesterol metabolism through increases in unphosphorylated steroidogenic acute regulatory (StAR) protein Molecular and Cellular Endocrinology. 231: 95-107. PMID 15713539 DOI: 10.1016/J.Mce.2004.08.006  1
2005 Galván N, Teske DE, Zhou G, Moorthy B, MacWilliams PS, Czuprynski CJ, Jefcoate CR. Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity. Toxicology and Applied Pharmacology. 202: 244-57. PMID 15667830 DOI: 10.1016/J.Taap.2004.06.026  1
2005 Hanlon PR, Zheng W, Ko AY, Jefcoate CR. Identification of novel TCDD-regulated genes by microarray analysis. Toxicology and Applied Pharmacology. 202: 215-28. PMID 15667827 DOI: 10.1016/J.Taap.2004.06.018  1
2005 Zheng W, Jefcoate CR. Steroidogenic factor-1 interacts with cAMP response element-binding protein to mediate cAMP stimulation of CYP1B1 via a far upstream enhancer Molecular Pharmacology. 67: 499-512. PMID 15523052 DOI: 10.1124/Mol.104.005504  1
2004 Duan H, Jefcoate C. Effective StAR expression in mouse MA-10 and Y-1 cells: extensive overexpression does not increase basal or cAMP-induced steroidogenesis. Endocrine Research. 30: 769. PMID 15666824 DOI: 10.1081/Erc-200044033  1
2004 Artemenko IP, Jefcoate CR. Multiple contributions from long-chain fatty acid metabolism in Y-1 and MA-10 cells Endocrine Research. 30: 637. PMID 15666804 DOI: 10.1081/Erc-200043909  1
2004 Kleiner HE, Vulimiri SV, Hatten WB, Reed MJ, Nebert DW, Jefcoate CR, DiGiovanni J. Role of cytochrome P4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis Chemical Research in Toxicology. 17: 1667-1674. PMID 15606143 DOI: 10.1021/Tx049919C  1
2004 Cho YC, Zheng W, Jefcoate CR. Disruption of cell-cell contact maximally but transiently activates AhR-mediated transcription in 10T1/2 fibroblasts. Toxicology and Applied Pharmacology. 199: 220-38. PMID 15364539 DOI: 10.1016/J.Taap.2003.12.025  1
2004 Larsen MC, Brake PB, Pollenz RS, Jefcoate CR. Linked expression of Ah receptor, ARNT, CYP1A1, and CYP1B1 in rat mammary epithelia, in vitro, is each substantially elevated by specific extracellular matrix interactions that precede branching morphogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 82: 46-61. PMID 15297627 DOI: 10.1093/Toxsci/Kfh242  1
2004 Page TJ, MacWilliams PS, Suresh M, Jefcoate CR, Czuprynski CJ. 7-12 Dimethylbenz[a]anthracene-induced bone marrow hypocellularity is dependent on signaling through both the TNFR and PKR. Toxicology and Applied Pharmacology. 198: 21-8. PMID 15207645 DOI: 10.1016/J.Taap.2004.02.014  1
2004 Cimafranca MA, Hanlon PR, Jefcoate CR. TCDD administration after the pro-adipogenic differentiation stimulus inhibits PPARgamma through a MEK-dependent process but less effectively suppresses adipogenesis. Toxicology and Applied Pharmacology. 196: 156-68. PMID 15050417 DOI: 10.1016/J.Taap.2003.12.005  1
2004 Cho YC, Jefcoate CR. PPARgamma1 synthesis and adipogenesis in C3H10T1/2 cells depends on S-phase progression, but does not require mitotic clonal expansion. Journal of Cellular Biochemistry. 91: 336-53. PMID 14743393 DOI: 10.1002/Jcb.10743  1
2003 Galván N, Jaskula-Sztul R, MacWilliams PS, Czuprynski CJ, Jefcoate CR. Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver. Toxicology and Applied Pharmacology. 193: 84-96. PMID 14613719 DOI: 10.1016/S0041-008X(03)00338-7  1
2003 Zhang L, Zheng W, Jefcoate CR. Ah receptor regulation of mouse Cyp1B1 is additionally modulated by a second novel complex that forms at two AhR response elements Toxicology and Applied Pharmacology. 192: 174-190. PMID 14550751 DOI: 10.1016/S0041-008X(03)00276-X  1
2003 Zheng W, Brake PB, Bhattacharyya KK, Zhang L, Zhao D, Jefcoate CR. Cell selective cAMP induction of rat CYP1B1 in adrenal and testis cells. Identification of a novel cAMP-responsive far upstream enhancer and a second Ah receptor-dependent mechanism Archives of Biochemistry and Biophysics. 416: 53-67. PMID 12859982 DOI: 10.1016/S0003-9861(03)00282-0  1
2003 Hanlon PR, Ganem LG, Cho YC, Yamamoto M, Jefcoate CR. AhR- and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-gamma1 expression and subsequent adipocyte differentiation. Toxicology and Applied Pharmacology. 189: 11-27. PMID 12758056 DOI: 10.1016/S0041-008X(03)00083-8  1
2003 Page TJ, O'Brien S, Holston K, MacWilliams PS, Jefcoate CR, Czuprynski CJ. 7,12-Dimethylbenz[a]anthracene-induced bone marrow toxicity is p53-dependent. Toxicological Sciences : An Official Journal of the Society of Toxicology. 74: 85-92. PMID 12730609 DOI: 10.1093/Toxsci/Kfg115  1
2002 Jefcoate C. High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex Journal of Clinical Investigation. 110: 881-890. PMID 12370263 DOI: 10.1172/Jci16771  1
2002 Page TJ, O'Brien S, Jefcoate CR, Czuprynski CJ. 7,12-Dimethylbenz[a]anthracene induces apoptosis in murine pre-B cells through a caspase-8-dependent pathway. Molecular Pharmacology. 62: 313-9. PMID 12130683 DOI: 10.1124/Mol.62.2.313  1
2002 Jefcoate C, Capponi A. Session summary Endocrine Research. 28: 371-373.  1
2001 Artemenko IP, Zhao D, Hales DB, Hales KH, Jefcoate CR. Mitochondrial Processing of Newly Synthesized Steroidogenic Acute Regulatory Protein (StAR), but Not Total StAR, Mediates Cholesterol Transfer to Cytochrome P450 Side Chain Cleavage Enzyme in Adrenal Cells Journal of Biological Chemistry. 276: 46583-46596. DOI: 10.1074/jbc.M107815200  1
2000 Jefcoate CR, Artemenko IP, Zhao D. Relationship of StAR expression to mitochondrial cholesterol transfer and metabolism Endocrine Research. 26: 663-680. PMID 11196443 DOI: 10.3109/07435800009048586  1
2000 Angus WGR, Campaigne Larsen M, Jefcoate CR. TCDD elevates erbB2 expression and signaling in T47D cells by reversing serum potentiation of estrogen receptor activity, independent of estrogen levels and enhanced ER down-regulation Molecular and Cellular Endocrinology. 170: 1-13. PMID 11162886 DOI: 10.1016/S0303-7207(00)00337-3  1
2000 Jefcoate CR, Liehr JG, Santen RJ, Sutter TR, Yager JD, Yue W, Santner SJ, Tekmal R, Demers L, Pauley R, Naftolin F, Mor G, Berstein L. Tissue-specific synthesis and oxidative metabolism of estrogens. Journal of the National Cancer Institute. Monographs. 95-112. PMID 10963622 DOI: 10.1093/Oxfordjournals.Jncimonographs.A024248  1
2000 Heidel SM, MacWilliams PS, Baird WM, Dashwood WM, Buters JT, Gonzalez FJ, Larsen MC, Czuprynski CJ, Jefcoate CR. Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene. Cancer Research. 60: 3454-60. PMID 10910056  1
1999 Alexander DL, Zhang L, Foroozesh M, Alworth WL, Jefcoate CR. Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity. Toxicology and Applied Pharmacology. 161: 123-39. PMID 10581206 DOI: 10.1006/Taap.1999.8794  1
1999 Heidel SM, Holston K, Buters JTM, Gonzalez FJ, Jefcoate CR, Czupyrynski CJ. Bone marrow stromal cell cytochrome P4501B1 is required for pre-B cell apoptosis induced by 7,12-dimethylbenz[a]anthracene Molecular Pharmacology. 56: 1317-1323. PMID 10570060 DOI: 10.1124/Mol.56.6.1317  1
1999 Ikegwuonu FI, Jefcoate CR. Evidence for the involvement of the fatty acid and peroxisomal β-oxidation pathways in the inhibition by dehydroepiandrosterone (DHEA) and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benz(a)anthracene (BA) of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblasts (C3H10T1/2 cells) Molecular and Cellular Biochemistry. 198: 89-100. PMID 10497882 DOI: 10.1023/A:1006954216233  1
1999 Angus WG, Larsen MC, Jefcoate CR. Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status. Carcinogenesis. 20: 947-55. PMID 10357772 DOI: 10.1093/Carcin/20.6.947  1
1999 Brake PB, Arai M, As-Sanie S, Jefcoate CR, Widmaier EP. Developmental expression and regulation of adrenocortical cytochrome P4501B1 in the rat Endocrinology. 140: 1672-1680. PMID 10098502 DOI: 10.1210/Endo.140.4.6628  1
1999 Buters JTM, Sakai S, Richter T, Pineau T, Alexander DL, Savas U, Doehmer J, Ward JM, Jefcoate CR, Gonzalez FJ. Cytochrome p450 CYP1B1 determines susceptibility to 7,12- dimethylbenz[a]anthracene-induced lymphomas Proceedings of the National Academy of Sciences of the United States of America. 96: 1977-1982. PMID 10051580 DOI: 10.1073/Pnas.96.5.1977  1
1999 Eltom SE, Zhang L, Jefcoate CR. Regulation of cytochrome P-450 (CYP) 1B1 in mouse hepa-1 variant cell lines: A possible role for aryl hydrocarbon receptor nuclear translocator (ARNT) as a suppressor of CYP1B1 gene expression Molecular Pharmacology. 55: 594-604. PMID 10051545  1
1999 Ikegwuonu FI, Christou M, Jefcoate CR. Regulation of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblast (C3H10T1/2) cells by protein kinase C (PKC) Biochemical Pharmacology. 57: 619-630. PMID 10037446 DOI: 10.1016/S0006-2952(98)00344-X  1
1999 Ganem LG, Trottier E, Anderson A, Jefcoate CR. Phenobarbital induction of CYP2B1/2 in primary hepatocytes: Endocrine regulation and evidence for a single pathway for multiple inducers Toxicology and Applied Pharmacology. 155: 32-42. PMID 10036216 DOI: 10.1006/Taap.1998.8599  1
1999 Huang YW, Karasov WH, Patnode KA, Jefcoate CR. Exposure of northern leopard frogs in the Green Bay ecosystem to polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans is measured by direct chemistry but not hepatic ethoxyresorufin-O-deethylase activity Environmental Toxicology and Chemistry. 18: 2123-2130. DOI: 10.1897/1551-5028(1999)018<2123:Eonlfi>2.3.Co;2  1
1998 Heidel SM, Czuprynski CJ, Jefcoate CR. Bone marrow stromal cells constitutively express high levels of cytochrome P4501b1 that metabolize 7,12-dimethylbenz[a]anthracene Molecular Pharmacology. 54: 1000-1006. PMID 9855628 DOI: 10.1124/Mol.54.6.1000  1
1998 Brake PB, Zhang L, Jefcoate CR. Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: Evidence for transcriptional repression by glucocorticoids Molecular Pharmacology. 54: 825-833. PMID 9804617 DOI: 10.1124/Mol.54.5.825  1
1998 Alexander DL, Ganem LG, Fernandez-Salguero P, Gonzalez F, Jefcoate CR. Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis Journal of Cell Science. 111: 3311-3322. PMID 9788873  1
1998 Eltom SE, Larsen MC, Jefcoate CR. Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: role of the Ah receptor. Carcinogenesis. 19: 1437-44. PMID 9744540 DOI: 10.1093/Carcin/19.8.1437  1
1998 Ganem LG, Jefcoate CR. Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner Toxicology and Applied Pharmacology. 150: 68-75. PMID 9630454 DOI: 10.1006/Taap.1998.8391  1
1998 Luch A, Coffing SL, Tang YM, Schneider A, Soballa V, Greim H, Jefcoate CR, Seidel A, Greenlee WF, Baird WM, Doehmer J. Stable expression of human cytochrome P450 1B1 in V79 chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene Chemical Research in Toxicology. 11: 686-695. PMID 9625737 DOI: 10.1021/Tx970236P  1
1998 Larsen MC, Angus WG, Brake PB, Eltom SE, Sukow KA, Jefcoate CR. Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism. Cancer Research. 58: 2366-74. PMID 9622076  1
1998 Ariyoshi N, Kim YC, Artemenko I, Bhattacharyya KK, Jefcoate CR. Characterization of the rat Star gene that encodes the predominant 3.5- kilobase pair mRNA Journal of Biological Chemistry. 273: 7610-7619. PMID 9516465 DOI: 10.1074/Jbc.273.13.7610  1
1998 Zhang L, Savas U, Alexander DL, Jefcoate CR. Characterization of the mouse Cyp1B1 gene: Identification of an enhancer region that directs aryl hydrocarbon receptor-mediated constitutive and induced expression Journal of Biological Chemistry. 273: 5174-5183. PMID 9478971 DOI: 10.1074/Jbc.273.9.5174  1
1997 Alexander DL, Eltom SE, Jefcoate CR. Ah receptor regulation of CYP1B1 expression in primary mouse embryo- derived cells Cancer Research. 57: 4498-4506. PMID 9377560  1
1997 Savas U, Carstens CP, Jefcoate CR. Biological oxidations and P450 reactions: Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1 Archives of Biochemistry and Biophysics. 347: 181-192. PMID 9367523 DOI: 10.1006/Abbi.1997.0339  1
1997 Einolf HJ, Story WT, Marcus CB, Larsen MC, Jefcoate CR, Greenlee WF, Yagi H, Jerina DM, Amin S, Park SS, Gelboin HV, Baird WM. Role of cytochrome P450 enzyme induction in the metabolic activation of benzo[c]phenanthrene in human cell lines and mouse epidermis. Chemical Research in Toxicology. 10: 609-17. PMID 9168260 DOI: 10.1021/Tx960174N  1
1997 Elliott ME, Goodfriend TL, Ball DL, Jefcoate CR. Angiotensin-responsive adrenal glomerulosa cell proteins: Characterization by protease mapping, species comparison, and specific angiotensin receptor antagonists Endocrinology. 138: 2530-2536. PMID 9165045 DOI: 10.1210/Endo.138.6.5207  1
1997 Santostefano MJ, Ross DG, Savas U, Jefcoate CR, Birnbaum LS. Differential time-course and dose-response relationships of TCDD-induced CYP1B1, CYP1A1, and CYP1A2 proteins in rats Biochemical and Biophysical Research Communications. 233: 20-24. PMID 9144388 DOI: 10.1006/Bbrc.1997.6389  1
1997 Kim YC, Ariyoshi N, Artemenko I, Elliott ME, Bhattacharyya KK, Jefcoate CR. Control of cholesterol access to cytochrome P450scc in rat adrenal cells mediated by regulation of the steroidogenic acute regulatory protein Steroids. 62: 10-20. PMID 9029709 DOI: 10.1016/S0039-128X(96)00153-5  1
1997 Brake PB, Jefcoate CR. Regulation of expression of CYPIB1 by steroid hormones and the AH receptor in the rat mammary gland Faseb Journal. 11: A1378.  1
1997 Ganem LG, Jefcoate CR. Endocrine-dependent strain differences in phenobarbital (PB) induction are maintained in primary hepatocyte cultures Faseb Journal. 11: A816.  1
1996 Desrochers M, Christou M, Jefcoate C, Belzil A, Anderson A. New proteins in the rat CYP2B subfamily: Presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA Biochemical Pharmacology. 52: 1311-1319. PMID 8937440 DOI: 10.1016/0006-2952(96)00502-3  1
1996 Bowes RC, Parrish AR, Steinberg MA, Willett KL, Zhao W, Savas U, Jefcoate CR, Safe SH, Ramos KS. Atypical cytochrome P450 induction profiles in glomerular mesangial cells at the mRNA and enzyme level: Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism Biochemical Pharmacology. 52: 587-595. PMID 8759031 DOI: 10.1016/0006-2952(96)00310-3  1
1996 Ikegwuonu FI, Ganem LG, Larsen MC, Shen X, Jefcoate CR. The regulation by gender, strain, dose, and feeding status of the induction of multiple forms of cytochrome p450 isozymes in rat hepatic microsomes by 2,4,5,2',4',5'-hexachlorobiphenyl Toxicology and Applied Pharmacology. 139: 33-41. PMID 8685906 DOI: 10.1006/Taap.1996.0140  1
1996 Jefcoate CR. Cytochrome P450SCC and Regulation of Cholesterol Conversion to Steroid Hormones Advances in Molecular and Cell Biology. 14: 103-148. DOI: 10.1016/S1569-2558(08)60342-2  1
1996 Jefcoate CR. P450 Cytochromes and Hormonal Regulation: An Overview Advances in Molecular and Cell Biology. 14: 1-28. DOI: 10.1016/S1569-2558(08)60338-0  1
1996 Jefcoate CR. Preface Advances in Molecular and Cell Biology. 14: xi-xii. DOI: 10.1016/S1569-2558(08)60337-9  1
1995 Christou M, Savas U, Schroeder S, Shen X, Thompson T, Gould MN, Jefcoate CR. Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland: Cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones Molecular and Cellular Endocrinology. 115: 41-50. PMID 8674863 DOI: 10.1016/0303-7207(95)03668-W  1
1995 Connor K, Safe S, Jefcoate CR, Larsen M. Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats Biochemical Pharmacology. 50: 1913-1920. PMID 8615872 DOI: 10.1016/0006-2952(95)02087-X  1
1995 Bhattacharyya KK, Brake PB, Eltom SE, Otto SA, Jefcoate CR. Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1: Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation Journal of Biological Chemistry. 270: 11595-11602. PMID 7744798 DOI: 10.1074/Jbc.270.19.11595  1
1995 Yamazaki T, Kowluru R, Mcnamara BC, Jefcoate CR. P450SCC-Dependent Cholesterol-Metabolism in Rat Adrenal Mitochondria Is Inhibited by Low Concentrations of Matrix Ca2+ 1 Archives of Biochemistry and Biophysics. 318: 131-139. PMID 7726553 DOI: 10.1006/abbi.1995.1213  1
1995 Nuwaysir EF, Dragan YP, Jefcoate CR, Jordan VC, Pitot HC. Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver. Cancer Research. 55: 1780-6. PMID 7712488  1
1995 Larsen MC, Jefcoate CR. Phenobarbital induction of CYP2B1, CYP2B2, and CYP3A1 in rat liver: genetic differences in a common regulatory mechanism. Archives of Biochemistry and Biophysics. 321: 467-76. PMID 7646073 DOI: 10.1006/abbi.1995.1419  1
1995 Brake PB, Jefcoate CR. Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3',5'-monophosphate and 2,3,7,8-tetrachlorodibenzo-p-dioxin Endocrinology. 136: 5034-5041. PMID 7588239 DOI: 10.1210/Endo.136.11.7588239  1
1995 Liehr JG, Ricci MJ, Jefcoate CR, Hannigan EV, Hokanson JA, Zhu BT. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 92: 9220-4. PMID 7568105 DOI: 10.1073/Pnas.92.20.9220  1
1995 Kowluru R, Yamazaki T, McNamara BC, Jefcoate CR. Metabolism of exogenous cholesterol by rat adrenal mitochondria is stimulated equally by physiological levels of free Ca2+ and by GTP Molecular and Cellular Endocrinology. 107: 181-188. PMID 7539386 DOI: 10.1016/0303-7207(94)03441-U  1
1994 Savas U, Bhattacharyya KK, Christou M, Alexander DL, Jefcoate CR. Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression Journal of Biological Chemistry. 269: 14905-14911. PMID 8195121  1
1994 Christou M, Savas U, Spink DC, Gierthy JF, Jefcoate CR. Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells Carcinogenesis. 15: 725-732. PMID 8149487 DOI: 10.1093/Carcin/15.4.725  1
1994 Savas U, Jefcoate CR. Dual regulation of cytochrome P450EF expression via the aryl hydrocarbon receptor and protein stabilization in C3H/10T1/2 cells Molecular Pharmacology. 45: 1153-1159. PMID 8022408  1
1994 Larsen MC, Brake PB, Parmar D, Jefcoate CR. The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific. Archives of Biochemistry and Biophysics. 315: 24-34. PMID 7979401 DOI: 10.1006/abbi.1994.1466  1
1994 Spink DC, Hayes CL, Young NR, Christou M, Sutter TR, Jefcoate CR, Gierthy JF. The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase Journal of Steroid Biochemistry and Molecular Biology. 51: 251-258. PMID 7826886 DOI: 10.1016/0960-0760(94)90037-X  1
1993 Christou M, Keith IM, Shen X, Schroeder ME, Jefcoate CR. Reversal of cytochrome P-4501A1 and P-450-EF expression in MCA-C3H/10T1/2 cell-derived tumors as compared to cultured cells Cancer Research. 53: 968-976. PMID 8439972  1
1993 Elliott ME, Goodfriend TL, Jefcoate CR. Bovine adrenal glomerulosa and fasciculata cells exhibit 28.5-kilodalton proteins sensitive to angiotensin, other agonists, and atrial natriuretic peptide Endocrinology. 133: 1669-1677. PMID 8404608 DOI: 10.1210/Endo.133.4.8404608  1
1993 Yamazaki T, McNamara BC, Jefcoate CR. Competition for electron transfer between cytochromes P450scc and P45011β in rat adrenal mitochondria Molecular and Cellular Endocrinology. 95: 1-11. PMID 8243798 DOI: 10.1016/0303-7207(93)90023-D  1
1993 Savas U, Christou M, Jefcoate CR. Mouse endometrium stromal cells express a polycyclic aromatic hydrocarbon-inducible cytochrome P450 that closely resembles the novel P450 in mouse embryo fibroblasts (P450EF) Carcinogenesis. 14: 2013-2018. PMID 8222047 DOI: 10.1093/Carcin/14.10.2013  1
1992 Jefcoate CR, McNamara BC, Artemenko I, Yamazaki T. Regulation of cholesterol movement to mitochondrial cytochrome P450scc in steroid hormone synthesis Journal of Steroid Biochemistry and Molecular Biology. 43: 751-767. PMID 22217822 DOI: 10.1016/0960-0760(92)90305-3  1
1992 Christou M, Mitchell MJ, Aoyama T, Gelboin HV, Gonzalez FJ, Jefcoate CR. Selective suppression of the catalytic activity of cDNA-expressed cytochrome P4502B1 toward polycyclic hydrocarbons in the microsomal membrane: Modification of this effect by specific amino acid substitutions Biochemistry. 31: 2835-2841. PMID 1547225 DOI: 10.1021/Bi00125A027  1
1992 Otto S, Bhattacharyya KK, Jefcoate CR. Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP) Endocrinology. 131: 3067-3076. PMID 1332854 DOI: 10.1210/Endo.131.6.1332854  1
1991 Dhariwal MS, Kowluru RA, Jefcoate CR. Cytochrome P-450scc induces vesicle aggregation through a secondary interaction at the adrenodoxin binding sites (in competition with protein exchange) Biochemistry. 30: 4940-4949. PMID 2036362 DOI: 10.1021/Bi00234A015  1
1991 Maltzman TH, Christou M, Gould MN, Jefcoate CR. Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes. Carcinogenesis. 12: 2081-7. PMID 1934293 DOI: 10.1093/Carcin/12.11.2081  1
1991 Pottenger LH, Christou M, Jefcoate CR. Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. Archives of Biochemistry and Biophysics. 286: 488-97. PMID 1910294 DOI: 10.1016/0003-9861(91)90070-Y  1
1991 Pidgeon C, Stevens J, Otto S, Jefcoate C, Marcus C. Immobilized artificial membrane chromatography: Rapid purification of functional membrane proteins Analytical Biochemistry. 194: 163-173. PMID 1907812 DOI: 10.1016/0003-2697(91)90164-O  1
1991 McNamara BC, Jefcoate CR. Succinate stimulation of isocitrate supported deoxycorticosterone metabolism in rat adrenal mitochondria by a synergistic mechanism. Endocrine Research. 17: 185-93. PMID 1879376 DOI: 10.1080/07435809109027196  1
1991 Otto S, Marcus C, Pidgeon C, Jefcoate C. A novel adrenocorticotropin-inducible cytochrome P450 from rat adrenal microsomes catalyzes polycyclic aromatic hydrocarbon metabolism Endocrinology. 129: 970-982. PMID 1649753 DOI: 10.1210/Endo-129-2-970  1
1991 Moore RW, Jefcoate CR, Peterson RE. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits steroidogenesis in the rat testis by inhibiting the mobilization of cholesterol to cytochrome P450scc. Toxicology and Applied Pharmacology. 109: 85-97. PMID 1645482 DOI: 10.1016/0041-008X(91)90193-I  1
1990 Marcus CB, Wilson NM, Jefcoate CR, Wilkinson CF, Omiecinski CJ. Selective induction of cytochrome P450 isozymes in rat liver by 4-n-alkyl-methylenedioxybenzenes. Archives of Biochemistry and Biophysics. 277: 8-16. PMID 2306127 DOI: 10.1016/0003-9861(90)90543-8  1
1990 Marcus CB, Wilson NM, Keith IM, Jefcoate CR, Omiecinski CJ. Selective expression of cytochrome P450 isozymes by 4-n-alkyl-methylenedioxybenzenes in rat lung cells. Archives of Biochemistry and Biophysics. 277: 17-25. PMID 2306118 DOI: 10.1016/0003-9861(90)90544-9  1
1990 Christou M, Stewart P, Pottenger LH, Fahl WE, Jefcoate CR. Differences in the modulation of P450IA1 and epoxide hydratase expression by benz[a]anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse embryo versus mouse hepatoma-derived cell lines. Carcinogenesis. 11: 1691-8. PMID 2208584 DOI: 10.1093/Carcin/11.10.1691  1
1990 McNamara BC, Jefcoate CR. Heterogeneous pools of cholesterol side-chain cleavage activity in adrenal mitochondria from adrenocorticotropic hormone-treated rats: reconstitution of the isocitrate response with succinate and low concentrations of isocitrate. Archives of Biochemistry and Biophysics. 283: 464-71. PMID 2177329 DOI: 10.1016/0003-9861(90)90668-O  1
1990 McNamara BC, Jefcoate CR. Heterogeneous pools of cholesterol side-chain cleavage activity in adrenal mitochondria from ACTH-treated rats: differential responses to different reducing precursors. Molecular and Cellular Endocrinology. 73: 123-34. PMID 2176627 DOI: 10.1016/0303-7207(90)90125-R  1
1990 Pottenger LH, Jefcoate CR. Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2. Carcinogenesis. 11: 321-7. PMID 2154339 DOI: 10.1093/Carcin/11.2.321  1
1989 Dhariwal MS, Jefcoate CR. Cholesterol metabolism by purified cytochrome P-450scc is highly stimulated by octyl glucoside and stearic acid exclusively in large unilamellar phospholipid vesicles. Biochemistry. 28: 8397-402. PMID 2605191 DOI: 10.1021/Bi00447A019  1
1989 McNamara BC, Jefcoate CR. The role of sterol carrier protein 2 in stimulation of steroidogenesis in rat adrenal mitochondria by adrenal cytosol. Archives of Biochemistry and Biophysics. 275: 53-62. PMID 2554812 DOI: 10.1016/0003-9861(89)90349-4  1
1989 Christou M, Jovanovich MC, Jefcoate CR. Epoxide hydratase: sex specific expression and rate-limiting role in DMBA metabolism. Carcinogenesis. 10: 1883-90. PMID 2507189 DOI: 10.1093/Carcin/10.10.1883  1
1989 Christou M, Mitchell MJ, Jovanovich MC, Wilson NM, Jefcoate CR. Selective potent restriction of P450b- but not P450e-dependent 7,12-dimethylbenz[a]anthracene metabolism by the microsomal environment. Archives of Biochemistry and Biophysics. 270: 162-72. PMID 2494942 DOI: 10.1016/0003-9861(89)90018-0  1
1988 Niranjan BG, Raza H, Shayiq RM, Jefcoate CR, Avadhani NG. Hepatic mitochondrial cytochrome P-450 system. Identification and characterization of a precursor form of mitochondrial cytochrome P-450 induced by 3-methylcholanthrene. The Journal of Biological Chemistry. 263: 575-80. PMID 3335509  1
1988 Turner NA, Wilson NM, Jefcoate CR, Pitot HC. The expression and metabolic activity of cytochrome P-450 isozymes in control and phenobarbital-induced primary cultures of rat hepatocytes. Archives of Biochemistry and Biophysics. 263: 204-15. PMID 3130800 DOI: 10.1016/0003-9861(88)90629-7  1
1988 McNamara BC, Jefcoate CR. Synergistic stimulation of pregnenolone synthesis in rat adrenal mitochondria by n-hexane and cardiolipin. Archives of Biochemistry and Biophysics. 260: 780-8. PMID 2829741 DOI: 10.1016/0003-9861(88)90508-5  1
1987 Keith IM, Olson EB, Wilson NM, Jefcoate CR. Immunological identification and effects of 3-methylcholanthrene and phenobarbital on rat pulmonary cytochrome P-450. Cancer Research. 47: 1878-82. PMID 3545456  1
1987 Christou M, Wilson NM, Jefcoate CR. Expression and function of three cytochrome P-450 isozymes in rat extrahepatic tissues. Archives of Biochemistry and Biophysics. 258: 519-34. PMID 3118810 DOI: 10.1016/0003-9861(87)90374-2  1
1987 Wilson NM, Christou M, Jefcoate CR. Differential expression and function of three closely related phenobarbital-inducible cytochrome P-450 isozymes in untreated rat liver. Archives of Biochemistry and Biophysics. 256: 407-20. PMID 3113333 DOI: 10.1016/0003-9861(87)90597-2  1
1987 Keller GM, Christou M, Pottenger LH, Wilson NM, Jefcoate CR. Product inhibition of benzo[a]pyrene metabolism in uninduced rat liver microsomes: effect of diol epoxide formation. Chemico-Biological Interactions. 61: 159-75. PMID 3103934 DOI: 10.1016/0009-2797(87)90037-8  1
1987 Christou M, Moore CJ, Gould MN, Jefcoate CR. Induction of mammary cytochromes P-450: an essential first step in the metabolism of 7,12-dimethylbenz[a]anthracene by rat mammary epithelial cells. Carcinogenesis. 8: 73-80. PMID 3100087 DOI: 10.1093/Carcin/8.1.73  1
1987 DiBartolomeis MJ, Moore RW, Peterson RE, Christian BJ, Jefcoate CR. Altered regulation of adrenal steroidogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats. Biochemical Pharmacology. 36: 59-67. PMID 3026405 DOI: 10.1016/0006-2952(87)90382-0  1
1987 Jefcoate CR, DiBartolomeis MJ, Williams CA, McNamara BC. ACTH regulation of cholesterol movement in isolated adrenal cells. Journal of Steroid Biochemistry. 27: 721-9. PMID 2826904 DOI: 10.1016/0022-4731(87)90142-7  1
1987 Privalle CT, McNamara BC, Dhariwal MS, Jefcoate CR. ACTH control of cholesterol side-chain cleavage at adrenal mitochondrial cytochrome P-450scc. Regulation of intramitochondrial cholesterol transfer. Molecular and Cellular Endocrinology. 53: 87-101. PMID 2822509 DOI: 10.1016/0303-7207(87)90195-X  1
1986 DiBartolomeis MJ, Moore RW, Peterson RE, Jefcoate CR. Hypercholesterolemia and the regulation of adrenal steroidogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats. Toxicology and Applied Pharmacology. 85: 313-23. PMID 3764917 DOI: 10.1016/0041-008X(86)90338-8  1
1986 Christou M, Marcus C, Jefcoate CR. Selective interactions of cytochromes P-450 with the hydroxymethyl derivatives of 7,12-dimethylbenz[a]anthracene Carcinogenesis. 7: 871-877. PMID 3085967 DOI: 10.1093/Carcin/7.6.871  1
1986 Jefcoate CR, Mcnamara BC, Dibartolomeis MJ. Control of steroid synthesis in adrenal fasciculata cells Endocrine Research. 12: 315-350. PMID 3030718 DOI: 10.3109/07435808609035444  1
1986 Dibartolomeis MJ, Christou M, Jefcoate CR. Regulation of rat and bovine adrenal metabolism of polycyclic aromatic hydrocarbons by adrenocorticotropin and 2,3,7,8-tetrachlorodibenzo-p-dioxin Archives of Biochemistry and Biophysics. 246: 428-438. PMID 3008659 DOI: 10.1016/0003-9861(86)90489-3  1
1986 DiBartolomeis MJ, Williams C, Jefcoate CR. Inhibition of ACTH action on cultured bovine adrenal cortical cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin through a redistribution of cholesterol Journal of Biological Chemistry. 261: 4432-4437. PMID 3007456  1
1985 Turner CR, Marcus CB, Jefcoate CR. Selectivity in the binding of hydroxylated benzo[a]pyrene derivatives to purified cytochrome P-450c Biochemistry. 24: 5124-5130. PMID 4074683 DOI: 10.1021/Bi00340A025  1
1985 Marcus CB, Turner CR, Jefcoate CR. Binding of benzo[a]pyrene by purified cytochrome P-450c Biochemistry. 24: 5115-5123. PMID 4074682 DOI: 10.1021/Bi00340A024  1
1985 Narasimhulu S, Eddy CR, Dibartolomeis M, Kowluru R, Jefcoate CR. Adrenal microsomal hydroxylating system: Purification and substrate binding properties of cytochrome P-450C-21 Biochemistry. 24: 4287-4294. PMID 3931675 DOI: 10.1021/Bi00337A006  1
1984 Keller GM, Jefcoate CR. Benzo(a)pyrene activation to 7,8-dihydrodiol 9,10-oxide by rat liver microsomes. Control by selective product inhibition Journal of Biological Chemistry. 259: 13770-13776. PMID 6438082  1
1984 Niranjan BG, Wilson NM, Jefcoate CR, Avadhani NG. Hepatic mitochondrial cytochrome P-450 system. Distinctive features of cytochrome P-450 involved in the activation of aflatoxin B1 and benzo(a)pyrene. The Journal of Biological Chemistry. 259: 12495-501. PMID 6436235  1
1984 Wilson NM, Christou M, Turner CR, Wrighton SA, Jefcoate CR. Binding and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene by seven purified forms of cytochrome P-450. Carcinogenesis. 5: 1475-83. PMID 6435901 DOI: 10.1093/Carcin/5.11.1475  1
1984 Dibartolomeis MJ, Jefcoate CR. The interrelationship of polycyclic hydrocarbon metabolism and steroidogenesis in primary cultures of bovine adrenal cortical cells Molecular Pharmacology. 25: 476-486. PMID 6328266  1
1984 DiBartolomeis MJ, Jefcoate CR. Characterization of the acute stimulation of steroidogenesis in primary bovine adrenal cortical cell cultures Journal of Biological Chemistry. 259: 10159-10167. PMID 6088483  1
1984 Kovluru RA, Privalle CT, Jefcoate CR. Control of cholesterol movement to cytochrome P-450(acc) in rat adrenal mitochondria Federation Proceedings. 43: no. 339.  1
1984 Christou M, Wilson NM, Jefcoate CR. The role of secondary metabolism in the metabolic activation of 7,12-dimethylbenz[a]anthracene by rat liver microsomes Carcinogenesis. 5: 1239-1247.  1
1983 Keller GM, Jefcoate CR. Modulation of microsomal benzo[a]pyrene metabolism by DNA Molecular Pharmacology. 23: 735-742. PMID 6306433  1
1983 Kowluru RA, George R, Jefcoate CR. Polyphosphoinositide activation of cholesterol side chain cleavage with purified cytochrome P-450(scc) Journal of Biological Chemistry. 258: 8053-8059. PMID 6305968  1
1983 Privalle CT, Crivello JF, Jefcoate CR. Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland Proceedings of the National Academy of Sciences of the United States of America. 80: 702-706. PMID 6298770 DOI: 10.1073/Pnas.80.3.702  1
1982 Kramer RE, Du Bois RN, Simpson ER, Anderson CM, Kashiwagi K, Lambeth JD, Jefcoate CR, Waterman MR. Cell-free synthesis of precursor forms of mitochondrial steroid hydroxylase enzymes of the bovine adrenal cortex Archives of Biochemistry and Biophysics. 215: 478-485. PMID 7092239 DOI: 10.1016/0003-9861(82)90106-0  1
1982 Jefcoate CR. pH modulation of ligand binding to adrenal mitochondrial cytochrome P-450scc Journal of Biological Chemistry. 257: 4731-4737. PMID 7068661  1
1982 Wrighton SA, Fahl WE, Shinnick FL, Jefcoate CR. Characteristics of microsomal reduction of benzo[a]pyrene 4,5-oxide. Chemico-Biological Interactions. 40: 345-56. PMID 6282475 DOI: 10.1016/0009-2797(82)90157-0  1
1982 Privalle CT, George R, Jefcoate CR. Regulation of cholesterol metabolism in rat adrenal mitochondria Federation Proceedings. 41: No. 3581.  1
1981 Hanukoglu I, Spitsberg V, Bumpus JA, Dus KM, Jefcoate CR. Adrenal mitochondrial cytochrome P-450scc. Cholesterol and adrenodoxin interactions at equilibrium and during turnover. The Journal of Biological Chemistry. 256: 4321-8. PMID 7217084  1
1981 Hanukoglu I, Privalle CT, Jefcoate CR. Mechanisms of ionic activation of adrenal mitochondrial cytochromes P-450scc and P-45011 beta. The Journal of Biological Chemistry. 256: 4329-35. PMID 6783659  1
1980 Torday JS, Jefcoate CR, First NL. Effect of prostaglandin F-2 alpha on steroidogenesis by porcine corpora lutea Journal of Reproduction and Fertility. 58: 301-310. PMID 7431262 DOI: 10.1530/jrf.0.0580301  1
1980 Dus KM, Litchfield WJ, Hippenmeyer PJ, Bumpus JA, Obidoa O, Spitsberg V, Jefcoate CR. Comparative immunochemical studies of cytochrome P-450CAM of Pseudomonas putida and of cytochrome P-450SCC of bovine adrenocortical mitochondria European Journal of Biochemistry. 111: 307-314. PMID 6780340 DOI: 10.1111/J.1432-1033.1980.Tb04943.X  1
1980 Shen AL, Fahl WE, Jefcoate CR. Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems. Archives of Biochemistry and Biophysics. 204: 511-23. PMID 6778394 DOI: 10.1016/0003-9861(80)90063-6  1
1980 Hanukoglu I, Jefcoate CR. Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin. The Journal of Biological Chemistry. 255: 3057-61. PMID 6766943  1
1980 Crivello JF, Jefcoate CR. Intracellular movement of cholesterol in rat adrenal cells. Kinetics and effects of inhibitors Journal of Biological Chemistry. 255: 8144-8151. PMID 6251046  1
1980 Hanukoglu I, Jefcoate CR. Pregnenolone separation from cholesterol using Sephadex LH-20 mini-columns Journal of Chromatography A. 190: 256-262. DOI: 10.1016/S0021-9673(00)85545-4  1
1979 Crivello JF, Jefcoate CR. The effects of cytochalasin B and vinblastine on movement of cholesterol in rat adrenal glands Biochemical and Biophysical Research Communications. 89: 1127-1134. PMID 496943 DOI: 10.1016/0006-291X(79)92125-9  1
1979 Gehly EB, Fahl WE, Jefcoate CR, Heidelberger C. The metabolism of benzo(alpha)pyrene by cytochrome P-450 in transformable and nontransformable C3H mouse fibroblasts. The Journal of Biological Chemistry. 254: 5041-8. PMID 447633  1
1979 Shen AL, Fahl WE, Wrighton SA, Jefcoate CR. Inhibition of benzo(a)pyrene and benzo(a)pyrene 7,8-dihydrodiol metabolism by benzo(a)pyrene quinones. Cancer Research. 39: 4123-9. PMID 113086  1
1979 Fahl WE, Michalopoulos G, Sattler GL, Jefcoate CR, Pitot HC. Characteristcs of microsomal enzyme controls in primary cultures of rat hepatocytes. Archives of Biochemistry and Biophysics. 192: 61-72. PMID 107860 DOI: 10.1016/0003-9861(79)90071-7  1
1979 Thomas PE, Korzeniowski D, Bresnick E, Bornstein WA, Kasper CB, Fahl WE, Jefcoate CR, Levin W. Hepatic cytochrome P-448 and epoxide hydrase: enzymes of nuclear origin are immunochemically identical with those of microsomal origin. Archives of Biochemistry and Biophysics. 192: 22-6. PMID 107858 DOI: 10.1016/0003-9861(79)90067-5  1
1979 Gehly EB, Fahl WE, Jefcoate CR. The metabolism of benzo(a)pyrene (BP) by cytochrome P450 in transformable and nontransformable C3H mouse fibroblasts Proceedings of the American Association For Cancer Research. 282.  1
1978 Fahl WE, Jefcoate CR, Kasper CB. Characteristics of benzo(a)pyrene metabolism and cytochrome P-450 heterogeneity in rat liver nuclear envelope and comparison to microsomal membrane. The Journal of Biological Chemistry. 253: 3106-13. PMID 641057  1
1978 Crivello JF, Jefcoate CR. Mechanism of corticotropin action in rat adrenal cells I. The effects of inhibitors of protein synthesis and of microfilament formation on corticosterone synthesis Bba - General Subjects. 542: 315-329. PMID 210838 DOI: 10.1016/0304-4165(78)90027-2  1
1978 Fahl WE, Shen AL, Jefcoate CR. UDP-glucuronosyl transferase and the conjugation of benzo(a)pyrene metabolites to DNA. Biochemical and Biophysical Research Communications. 85: 891-9. PMID 104718 DOI: 10.1016/0006-291X(78)90627-7  1
1978 Jefcoate CR. [27] Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy Methods in Enzymology. 52: 258-279. DOI: 10.1016/S0076-6879(78)52029-6  1
1977 Jefcoate CR. Cytochrome P-450 of adrenal mitochondria. Steroid binding sites on two distinguishable forms of rat adrenal mitochondrial cytochrome P-450(scc) Journal of Biological Chemistry. 252: 8788-8796. PMID 925024  1
1977 Fahl WE, Nesnow S, Jefcoate CR. Microsomal metabolism on benzo(a)pyrene. Multiple effects of epoxide hydrase inhibitors. Archives of Biochemistry and Biophysics. 181: 649-64. PMID 900937 DOI: 10.1016/0003-9861(77)90271-5  1
1977 Nesnow S, Fahl WE, Jefcoate CR. An improved radiochemical assay for benzo(a)pyrene monooxygenase. Analytical Biochemistry. 80: 258-66. PMID 883635 DOI: 10.1016/0003-2697(77)90644-3  1
1976 Jefcoate CR, Orme-Johnson WH, Beinhert H. Cytochrome P-450 of bovine adrenal mitochondria. Ligand binding to two forms resolved by EPR spectroscopy. The Journal of Biological Chemistry. 251: 3706-15. PMID 6460  1
1976 Fahl WE, Jefcoate CR, Nesnow SC. Relation between epoxide hydrase inhibition and total oxidase inhibition of aromatic hydrocarbons Proceedings of the American Association For Cancer Research. no. 877.  1
1975 Jefcoate CR, Orme-Johnson WH. Cytochrome P-450 of adrenal mitochondria. In vitro and in vivo changes in spin states. The Journal of Biological Chemistry. 250: 4671-7. PMID 167001  1
1975 Jefcoate CR. Cytochrome P 450 of adrenal mitochondria. Spin states as detected by difference spectroscopy Journal of Biological Chemistry. 250: 4663-4670. PMID 167000  1
1974 Jefcoate CR, Simpson ER, Boyd GS. Spectral properties of rat adrenal mitochondrial cytochrome P 450 European Journal of Biochemistry. 42: 539-551. PMID 4829445 DOI: 10.1111/J.1432-1033.1974.Tb03369.X  1
1974 Simpson ER, Jefcoate CR, McCarthy JL, Boyd GS. Effect of calcium ions on steroid binding spectra and pregnenolone formation in rat adrenal mitochondria European Journal of Biochemistry. 45: 181-188. PMID 4370765  1
1974 Ghazarian JG, Jefcoate CR, Knutson JC, Orme-Johnson WH, DeLuca HF. Mitochondrial cytochrome p450. A component of chick kidney 25-hydrocholecalciferol-1alpha-hydroxylase. The Journal of Biological Chemistry. 249: 3026-33. PMID 4151488  1
1973 Simpson ER, Jefcoate CR, Collett RA, Land RB. Cytochrome P 450 activity in sheep corpora lutea during the oestrous cycle Journal of Endocrinology. 58: 493-501. PMID 4795506  1
1973 Brownie AC, Alfano J, Jefcoate CR. Effect of ACTH on adrenal mitochondrial cytochrome P 450 in the rat Annals of the New York Academy of Sciences. 344-360. PMID 4375423 DOI: 10.1111/J.1749-6632.1973.Tb47606.X  1
1973 Jefcoate CR, Simpson ER, Boyd GS, Brownie AC, Orme-Johnson WH. The detection of different states of the P-450 cytochromes in adrenal mitochondria: changes induced by ACTH. Annals of the New York Academy of Sciences. 212: 243-61. PMID 4375421  1
1972 Boyd GS, Brownie AC, Jefcoate CR, Simpson ER. Cholesterol hydroxylation in the adrenal cortex and liver Biochemical Society Symposia. 34: 207-226. PMID 4348065  1
1972 Simpson ER, Trzeciak WH, McCarthy JL, Jefcoate CR, Boyd GS. Factors affecting cholesterol esterase and cholesterol side-chain-cleavage activities in rat adrenal Biochemical Journal. 129: 10P-11P. PMID 4345268  1
1972 Simpson ER, Jefcoate CR, Brownie AC, Boyd GS. The effect of ether anaesthesia stress on cholesterol-side-chain cleavage and cytochrome P450 in rat-adrenal mitochondria European Journal of Biochemistry. 28: 442-450. PMID 4342911 DOI: 10.1111/J.1432-1033.1972.Tb01931.X  1
1972 Brownie AC, Simpson ER, Jefcoate CR, Boyd GS, Orme-Johnson WH, Beinert H. Effect of ACTH on cholesterol side-chain cleavage in rat adrenal mitochondria. Biochemical and Biophysical Research Communications. 46: 483-90. PMID 4333417 DOI: 10.1016/S0006-291X(72)80164-5  1
1971 Jefcoate CR, Boyd GS. pH-Dependent changes in the spin state of cytochrome P450 from adrenal mitochondria Febs Letters. 12: 279-284. DOI: 10.1016/0014-5793(71)80199-0  1
1971 Simpson ER, Jefcoate CR, Boyd GS. Spin state changes in cytochrome P-450 associated with cholesterol side chain cleavage in bovine adrenal cortex mitochondria Febs Letters. 15: 53-58. DOI: 10.1016/0014-5793(71)80078-9  1
1970 Jefcoate CR, Gaylor JL. Ligand interactions with hemoprotein P-450. Equilibria between high- and low-spin forms of P-450 in bovine adrenal mitochondria. Biochemistry. 9: 3816-23. PMID 5507519 DOI: 10.1021/Bi00821A022  1
1970 Gaylor JL, Moir NJ, Seifried HE, Jefcoate CR. Assay and isolation of a cyanide-binding protein of rat liver microsomes. The Journal of Biological Chemistry. 245: 5511-3. PMID 5469178  1
1970 Jefcoate CR, Calabrese RL, Gaylor JL. Ligand interaction with hemoprotein P-450. 3. The use of n-octylamine and ethyl isocyanide difference spectroscopy in the quantitative determination of high- and low-spin P-450. Molecular Pharmacology. 6: 391-401. PMID 5429282  1
1970 Jefcoate CR, Hume R, Boyd GS. Separation of two forms of cytochrome P450 adrenal cortex mitochondria Febs Letters. 9: 41-44. DOI: 10.1016/0014-5793(70)80306-4  1
1969 Jefcoate CR, Gaylor JL, Calabrese RL. Ligand interactions with cytochrome P-450. I. Binding of primary amines. Biochemistry. 8: 3455-63. PMID 5809236 DOI: 10.1021/Bi00836A049  1
1969 Jefcoate CR, Gaylor JL. A model for the interaction of cytochrome P-450 with carbon monoxide. Journal of the American Chemical Society. 91: 4610-1. PMID 5796288  1
1969 Jefcoate CR, Gaylor JL. Ligand interactions with hemoprotein P-450. II. Influence of phenobarbital and methylcholanthrene induction processes on P-450 spectra. Biochemistry. 8: 3464-72. PMID 4309210 DOI: 10.1021/Bi00836A050  1
1968 Jefcoate CR, Smith L, Norman RO. Aromatic hydroxylation induced by the decomposition of hydrogen peroxide using either metal ions or U.V. irradiation. Hoppe-Seyler's Zeitschrift FüR Physiologische Chemie. 349: 1613-5. PMID 5745912  1
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