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Ben Shen - Publications

Affiliations: 
Chemistry The Scripps Research Institute, Scripps Florida 
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kalkreuter E, Kautsar SA, Yang D, Teijaro CN, Bader CD, Fluegel LL, Davis CM, Simpson JR, Steele AD, Gui C, Meng S, Li G, Viehrig K, Ye F, Su P, ... ... Shen B, et al. The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. Biorxiv : the Preprint Server For Biology. PMID 38168313 DOI: 10.1101/2023.12.14.571759  0.459
2023 Bhardwaj M, Cui Z, Daniel Hankore E, Moonschi FH, Saghaeiannejad Esfahani H, Kalkreuter E, Gui C, Yang D, Phillips GN, Thorson JS, Shen B, Van Lanen SG. A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220468120. PMID 36802426 DOI: 10.1073/pnas.2220468120  0.334
2023 Cao M, Yang D, Adhikari A, Ye F, Zheng C, Yan W, Meng S, Su P, Shen B. Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in J1074. Organic Letters. PMID 36735280 DOI: 10.1021/acs.orglett.2c04303  0.456
2023 Vega VF, Yang D, Jordán LO, Ye F, Conway L, Chen LY, Shumate J, Baillargeon P, Scampavia L, Souza G, Parker C, Shen B, Spicer TP. Protocol for 3D Screening of Lung Cancer Spheroids using Natural Products. Slas Discovery : Advancing Life Sciences R & D. PMID 36681384 DOI: 10.1016/j.slasd.2023.01.005  0.393
2022 Yang D, Ye F, Teijaro CN, Hwang D, Annaval T, Adhikari A, Li G, Yan X, Gui C, Rader C, Shen B. Functional Characterization of Cytochrome P450 Hydroxylase YpmL in Yangpumicin A Biosynthesis and Its Application for Anthraquinone-Fused Enediyne Structural Diversification. Organic Letters. PMID 35084871 DOI: 10.1021/acs.orglett.2c00009  0.494
2022 Ye F, Haniff HS, Suresh BM, Yang D, Zhang P, Crynen G, Teijaro CN, Yan W, Abegg D, Adibekian A, Shen B, Disney MD. Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA. Acs Chemical Biology. PMID 35044149 DOI: 10.1021/acschembio.1c00952  0.38
2021 Luo J, Yang D, Hindra, Adhikari A, Dong LB, Ye F, Yan X, Rader C, Shen B. Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis. Journal of Industrial Microbiology & Biotechnology. PMID 33982054 DOI: 10.1093/jimb/kuab027  0.504
2021 Hindra H, Yang D, Luo J, Huang T, Yan X, Adhikari A, Teijaro CN, Ge H, Shen B. Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production. Journal of Industrial Microbiology & Biotechnology. PMID 33739406 DOI: 10.1093/jimb/kuab025  0.32
2021 Cao M, Zheng C, Yang D, Kalkreuter E, Adhikari A, Liu YC, Rateb ME, Shen B. Cryptic sulfur incorporation in thioangucycline biosynthesis. Angewandte Chemie (International Ed. in English). PMID 33465268 DOI: 10.1002/anie.202015570  0.313
2020 Zheng CJ, Kalkreuter E, Fan BY, Liu YC, Dong LB, Shen B. PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine -Acetyltransferases. Acs Chemical Biology. PMID 33314918 DOI: 10.1021/acschembio.0c00773  0.32
2020 Zhou W, Liang H, Qin X, Cao D, Zhu X, Ju J, Shen B, Duan Y, Huang Y. The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. Journal of Natural Products. PMID 32049520 DOI: 10.1021/Acs.Jnatprod.9B00321  0.366
2019 Kalkreuter E, Pan G, Cepeda AJ, Shen B. Targeting Bacterial Genomes for Natural Product Discovery. Trends in Pharmacological Sciences. PMID 31822352 DOI: 10.1016/J.Tips.2019.11.002  0.312
2019 Steele AD, Teijaro CN, Yang D, Shen B. Leveraging a Large Microbial Strain Collection for Natural Product Discovery. The Journal of Biological Chemistry. PMID 31570525 DOI: 10.1074/Jbc.Rev119.006514  0.319
2018 Teijaro CN, Adhikari A, Shen B. Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts. Journal of Industrial Microbiology & Biotechnology. PMID 30426283 DOI: 10.1007/S10295-018-2094-5  0.346
2018 Kwong T, Ma M, Pan G, Hindra, Yang D, Yang C, Lohman JR, Rudolf JD, Cleveland JL, Shen B. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. Biochemistry. PMID 30070831 DOI: 10.1021/Acs.Biochem.8B00623  0.322
2018 Shen B, Dong LB, Rudolf JD, Deng MR, Yan X. Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases. Chembiochem : a European Journal of Chemical Biology. PMID 29806086 DOI: 10.1002/Cbic.201800285  0.309
2017 Pan G, Xu Z, Guo Z, Hindra, Ma M, Yang D, Zhou H, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, Cheng J, Van Nieuwerburgh F, Suh JW, ... ... Shen B, et al. Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proceedings of the National Academy of Sciences of the United States of America. PMID 29229819 DOI: 10.1073/Pnas.1716245115  0.344
2017 Yang D, Hindra, Dong LB, Crnovcic I, Shen B. Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin. The Journal of Antibiotics. PMID 28831149 DOI: 10.1038/Ja.2017.93  0.315
2016 Yan X, Ge H, Huang T, Hindra, Yang D, Teng Q, Crnovčić I, Li X, Rudolf JD, Lohman JR, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, ... ... Shen B, et al. Strain Prioritization and Genome Mining for Enediyne Natural Products. Mbio. 7. PMID 27999165 DOI: 10.1128/Mbio.02104-16  0.355
2016 Guo Z, Pan G, Xu Z, Yang D, Hindra, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883. The Journal of Antibiotics. PMID 27731333 DOI: 10.1038/Ja.2016.122  0.328
2015 Zhang B, Yang D, Yan Y, Pan G, Xiang W, Shen B. Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins. Applied Microbiology and Biotechnology. PMID 26552797 DOI: 10.1007/S00253-015-7119-7  0.306
2015 Rudolf JD, Yan X, Shen B. Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery. Journal of Industrial Microbiology & Biotechnology. PMID 26318027 DOI: 10.1007/S10295-015-1671-0  0.303
2015 Liu T, Ma M, Ge HM, Yang C, Cleveland J, Shen B. Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin. Bioorganic & Medicinal Chemistry Letters. PMID 26071634 DOI: 10.1016/J.Bmcl.2015.05.078  0.306
2014 Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry. 53: 7854-65. PMID 25405956 DOI: 10.1021/Bi501396V  0.318
2013 Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B. Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. Molecular Biosystems. 9: 478-91. PMID 23360970 DOI: 10.1039/C3Mb25523A  0.301
2012 Smanski MJ, Casper J, Peterson RM, Yu Z, Rajski SR, Shen B. Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners. Journal of Natural Products. 75: 2158-67. PMID 23157615 DOI: 10.1021/Np3005985  0.34
2010 Luo Y, Li W, Ju J, Yuan Q, Peters NR, Hoffmann FM, Huang SX, Bugni TS, Rajski S, Osada H, Shen B. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. Journal of the American Chemical Society. 132: 6663-71. PMID 20426415 DOI: 10.1021/Ja9082446  0.32
2009 Lim SK, Ju J, Zazopoulos E, Jiang H, Seo JW, Chen Y, Feng Z, Rajski SR, Farnet CM, Shen B. iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. The Journal of Biological Chemistry. 284: 29746-56. PMID 19726666 DOI: 10.1074/Jbc.M109.046805  0.316
2009 Chen Y, Wendt-Pienkoski E, Rajski SR, Shen B. In vivo investigation of the roles of FdmM and FdmM1 in fredericamycin biosynthesis unveiling a new family of oxygenases. The Journal of Biological Chemistry. 284: 24735-43. PMID 19620242 DOI: 10.1074/Jbc.M109.014191  0.339
2009 Liao R, Duan L, Lei C, Pan H, Ding Y, Zhang Q, Chen D, Shen B, Yu Y, Liu W. Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chemistry & Biology. 16: 141-7. PMID 19246004 DOI: 10.1016/J.Chembiol.2009.01.007  0.317
2009 Li W, Luo Y, Ju J, Rajski SR, Osada H, Shen B. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. Journal of Natural Products. 72: 450-9. PMID 19191560 DOI: 10.1021/Np8007478  0.33
2008 Li W, Ju J, Rajski SR, Osada H, Shen B. Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis. The Journal of Biological Chemistry. 283: 28607-17. PMID 18708355 DOI: 10.1074/Jbc.M804279200  0.311
2008 Galm U, Wang L, Wendt-Pienkowski E, Yang R, Liu W, Tao M, Coughlin JM, Shen B. In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway. The Journal of Biological Chemistry. 283: 28236-45. PMID 18697737 DOI: 10.1074/Jbc.M804971200  0.321
2008 Chen Y, Luo Y, Ju J, Wendt-Pienkowski E, Rajski SR, Shen B. Identification of fredericamycin E from Streptomyces griseus: Insights into fredericamycin A biosynthesis highlighting carbaspirocycle formation. Journal of Natural Products. 71: 431-7. PMID 18232659 DOI: 10.1021/Np070664N  0.304
2006 Van Lanen SG, Shen B. Microbial genomics for the improvement of natural product discovery. Current Opinion in Microbiology. 9: 252-60. PMID 16651020 DOI: 10.1016/J.Mib.2006.04.002  0.341
2003 Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotechnology. 21: 187-90. PMID 12536216 DOI: 10.1038/Nbt784  0.335
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