| Year |
Citation |
Score |
| 2024 |
Monte E, Furihata T, Wang G, Perea-Gil I, Wei E, Chaib H, Nair R, Guevara JV, Mares R, Cheng X, Zhuge Y, Black K, Serrano R, Dagan-Rosenfeld O, Maguire P, ... ... Karakikes I, et al. Personalized transcriptome signatures in a cardiomyopathy stem cell biobank. Biorxiv : the Preprint Server For Biology. PMID 38798547 DOI: 10.1101/2024.05.10.593618 |
0.513 |
|
| 2024 |
Arthur Ataam J, Belbachir N, Perea-Gil I, Termglincan V, Vadgama N, Garg P, Ramchandani R, Gavidia AA, Roura S, Gálvez-Montón C, Wu JC, Bayés-Genis A, Karakikes I. Empagliflozin Attenuates Arrhythmias in an iPSC-Based Model of Hypertrophy Cardiomyopathy. Circulation. Genomic and Precision Medicine. e004526. PMID 38752368 DOI: 10.1161/CIRCGEN.123.004526 |
0.404 |
|
| 2024 |
Cheawsamoot C, Ramchandani R, Ameen M, Arthur JA, Khongphatthanayothin A, Karakikes I, Shotelersuk V. Corrigendum to "Generation of human induced pluripotent stem cell lines derived from four patients with a pathogenic ALPK3 variant associated with adult-onset hypertrophic cardiomyopathy (HCM)" [Stem Cell Res. 73 (2023) 103233]. Stem Cell Research. 74: 103300. PMID 38176369 DOI: 10.1016/j.scr.2023.103300 |
0.362 |
|
| 2023 |
Cheawsamoot C, Ramchandani R, Ameen M, Arthur Ataam J, Khongphatthanayothin A, Shotelersuk V, Karakikes I. Generation of human induced pluripotent stem cell lines derived from four patients with a pathogenic ALPK3 variant associated with adult-onset hypertrophic cardiomyopathy (HCM). Stem Cell Research. 73: 103233. PMID 37944352 DOI: 10.1016/j.scr.2023.103233 |
0.337 |
|
| 2022 |
Serrano R, Feyen DAM, Bruyneel AAN, Hnatiuk AP, Vu MM, Amatya PL, Perea-Gil I, Prado M, Seeger T, Wu JC, Karakikes I, Mercola M. A deep learning platform to assess drug proarrhythmia risk. Cell Stem Cell. 30: 86-95.e4. PMID 36563695 DOI: 10.1016/j.stem.2022.12.002 |
0.721 |
|
| 2022 |
Ameen M, Sundaram L, Shen M, Banerjee A, Kundu S, Nair S, Shcherbina A, Gu M, Wilson KD, Varadarajan A, Vadgama N, Balsubramani A, Wu JC, Engreitz JM, Farh K, ... Karakikes I, et al. Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease. Cell. 185: 4937-4953.e23. PMID 36563664 DOI: 10.1016/j.cell.2022.11.028 |
0.736 |
|
| 2022 |
Rogalska ME, Vafiadaki E, Erpapazoglou Z, Haghighi K, Green L, Mantzoros CS, Hajjar RJ, Tranter M, Karakikes I, Kranias EG, Stillitano F, Kafasla P, Sanoudou D. Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts. Metabolism: Clinical and Experimental. 155344. PMID 36375644 DOI: 10.1016/j.metabol.2022.155344 |
0.405 |
|
| 2022 |
Perea-Gil I, Seeger T, Bruyneel AAN, Termglinchan V, Monte E, Lim EW, Vadgama N, Furihata T, Gavidia AA, Arthur Ataam J, Bharucha N, Martinez-Amador N, Ameen M, Nair P, Serrano R, ... ... Karakikes I, et al. Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy. European Heart Journal. PMID 35728000 DOI: 10.1093/eurheartj/ehac305 |
0.751 |
|
| 2022 |
Metzl-Raz E, Bharucha N, Arthur Ataam J, Gavidia AA, Greenleaf WJ, Karakikes I. Generation of a dual edited human induced pluripotent stem cell Myl7-GFP reporter line with inducible CRISPRi/dCas9. Stem Cell Research. 61: 102754. PMID 35325819 DOI: 10.1016/j.scr.2022.102754 |
0.395 |
|
| 2022 |
Martinez EC, Li J, Ataam JA, Tokarski K, Thakur H, Karakikes I, Dodge-Kafka K, Kapiloff MS. Targeting mAKAPβ expression as a therapeutic approach for ischemic cardiomyopathy. Gene Therapy. PMID 35102273 DOI: 10.1038/s41434-022-00321-w |
0.306 |
|
| 2021 |
Bharucha N, Ataam JA, Gavidia AA, Karakikes I. Generation of AAVS1 integrated doxycycline-inducible CRISPR-Prime Editor human induced pluripotent stem cell line. Stem Cell Research. 57: 102610. PMID 34875545 DOI: 10.1016/j.scr.2021.102610 |
0.33 |
|
| 2021 |
Feyen DAM, Perea-Gil I, Maas RGC, Harakalova M, Gavidia AA, Arthur Ataam J, Wu TH, Vink A, Pei J, Vadgama N, Suurmeijer AJ, Te Rijdt WP, Vu M, Amatya PL, Prado M, ... ... Karakikes I, et al. The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy. Circulation. PMID 33928785 DOI: 10.1161/CIRCULATIONAHA.120.049844 |
0.723 |
|
| 2021 |
Cheng J, Tsuda M, Okolotowicz K, Dwyer M, Bushway PJ, Colas AR, Lancman JJ, Schade D, Perea-Gil I, Bruyneel AAN, Lee J, Vadgama N, Quach J, McKeithan WL, Biechele TL, ... ... Karakikes I, et al. Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness. Cell Chemical Biology. PMID 33503403 DOI: 10.1016/j.chembiol.2021.01.001 |
0.392 |
|
| 2020 |
Levitas A, Muhammad E, Zhang Y, Perea Gil I, Serrano R, Diaz N, Arafat M, Gavidia AA, Kapiloff MS, Mercola M, Etzion Y, Parvari R, Karakikes I. A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy. Plos Genetics. 16: e1009000. PMID 32925938 DOI: 10.1371/Journal.Pgen.1009000 |
0.402 |
|
| 2020 |
Briganti F, Sun H, Wei W, Wu J, Zhu C, Liss M, Karakikes I, Rego S, Cipriano A, Snyder M, Meder B, Xu Z, Millat G, Gotthardt M, Mercola M, et al. iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy. Cell Reports. 32: 108117. PMID 32905764 DOI: 10.1016/J.Celrep.2020.108117 |
0.45 |
|
| 2020 |
Wilson KD, Ameen M, Guo H, Abilez OJ, Tian L, Mumbach MR, Diecke S, Qin X, Liu Y, Yang H, Ma N, Gaddam S, Cunningham NJ, Gu M, Neofytou E, ... ... Karakikes I, et al. Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates. Developmental Cell. PMID 32763147 DOI: 10.1016/J.Devcel.2020.07.006 |
0.806 |
|
| 2020 |
Tian L, Oikonomopoulos A, Liu C, Kitani T, Shrestha R, Chen CL, Ong SG, Smeets M, Karakikes I, Sayed N, Wu JC. Molecular Signatures of Beneficial Class Effects of Statins on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. 141: 1208-1210. PMID 32250699 DOI: 10.1161/Circulationaha.118.035906 |
0.788 |
|
| 2020 |
LaRocca TJ, Seeger T, Prado M, Perea-Gil I, Neofytou E, Mecham BH, Ameen M, Chang ACY, Pandey G, Wu JC, Karakikes I. Pharmacological Silencing of MicroRNA-152 Prevents Pressure Overload-Induced Heart Failure. Circulation. Heart Failure. 13: e006298. PMID 32160771 DOI: 10.1161/Circheartfailure.119.006298 |
0.718 |
|
| 2020 |
Zhang Y, Ameen M, Perea Gil I, Arthur J, Gavidia AA, Bharucha N, Wang KC, Karakikes I. Abstract MP175: Disruption of the Genome Architecture at the
PRRX1
Locus is Associated With the Pathogenesis of
LMNA
-related Dilated Cardiomyopathy Circulation Research. 127. DOI: 10.1161/res.127.suppl_1.mp175 |
0.393 |
|
| 2020 |
Perea Gil I, Bellbachir N, Gavidia AA, Arthur J, Zhang Y, Vadgama N, Oikonomopoulos A, Roura S, Wu JC, Bayes-Genis A, Karakikes I. Abstract 274: Activation of CaMKII Signaling Pathway Contributes to the Pathogenesis of Genetic Hypertrophic Cardiomyopathy Circulation Research. 127. DOI: 10.1161/res.127.suppl_1.274 |
0.44 |
|
| 2019 |
Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, ... ... Karakikes I, et al. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. PMID 31316208 DOI: 10.1038/S41586-019-1406-X |
0.753 |
|
| 2019 |
Nair P, Prado M, Perea-Gil I, Karakikes I. Concise Review: Precision Matchmaking: Induced Pluripotent Stem Cells Meet Cardio-Oncology. Stem Cells Translational Medicine. 8: 758-767. PMID 31020786 DOI: 10.1002/sctm.18-0279 |
0.329 |
|
| 2018 |
Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, ... ... Karakikes I, et al. A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Circulation. PMID 30586709 DOI: 10.1161/Circulationaha.118.034624 |
0.759 |
|
| 2018 |
Chang ACY, Chang ACH, Kirillova A, Sasagawa K, Su W, Weber G, Lin J, Termglinchan V, Karakikes I, Seeger T, Dainis AM, Hinson JT, Seidman J, Seidman CE, Day JW, et al. Telomere shortening is a hallmark of genetic cardiomyopathies. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150400 DOI: 10.1073/Pnas.1714538115 |
0.764 |
|
| 2018 |
Lee J, Shao NY, Paik DT, Wu H, Guo H, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC. SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation. Cell Stem Cell. 22: 428-444.e5. PMID 29499155 DOI: 10.1016/J.Stem.2018.02.005 |
0.745 |
|
| 2017 |
Zhao MT, Chen H, Liu Q, Shao NY, Sayed N, Wo HT, Zhang JZ, Ong SG, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez NM, Karakikes I, et al. Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proceedings of the National Academy of Sciences of the United States of America. PMID 29203658 DOI: 10.1073/Pnas.1708991114 |
0.794 |
|
| 2017 |
Abilez OJ, Tzatzalos E, Yang H, Zhao MT, Jung G, Zöllner AM, Tiburcy M, Riegler J, Matsa E, Shukla P, Zhuge Y, Chour T, Chen VC, Burridge PW, Karakikes I, et al. Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling. Stem Cells (Dayton, Ohio). PMID 29086457 DOI: 10.1002/Stem.2732 |
0.791 |
|
| 2017 |
Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo NA, Wilson KD, et al. A Comprehensive TALEN-Based Knockout Library for Generating Human Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Circulation Research. PMID 28246128 DOI: 10.1161/Circresaha.116.309948 |
0.802 |
|
| 2017 |
Stillitano F, Hansen J, Kong CW, Karakikes I, Funck-Brentano C, Geng L, Scott S, Reynier S, Wu M, Valogne Y, Desseaux C, Salem JE, Jeziorowska D, Zahr N, Li R, et al. Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells. Elife. 6. PMID 28134617 DOI: 10.7554/Elife.19406 |
0.377 |
|
| 2017 |
Stillitano F, Karakikes I, Hajjar RJ. Gene Transfer in Cardiomyocytes Derived from ES and iPS Cells. Methods in Molecular Biology (Clifton, N.J.). 1521: 183-193. PMID 27910049 DOI: 10.1007/978-1-4939-6588-5_12 |
0.443 |
|
| 2017 |
Termglinchan V, Seeger T, Chen C, Wu JC, Karakikes I. Efficient Genome Editing in Induced Pluripotent Stem Cells with Engineered Nucleases In Vitro. Methods in Molecular Biology (Clifton, N.J.). 1521: 55-68. PMID 27910041 DOI: 10.1007/978-1-4939-6588-5_4 |
0.742 |
|
| 2017 |
Chen C, Seeger T, Termglinchan V, Karakikes I. Recent advances in cardiac gene therapy strategies targeting advanced heart failure Continuing Cardiology Education. 3: 163-169. DOI: 10.1002/cce2.68 |
0.688 |
|
| 2016 |
Gu M, Shao NY, Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, et al. Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers. Cell Stem Cell. PMID 28017794 DOI: 10.1016/J.Stem.2016.08.019 |
0.797 |
|
| 2016 |
Kodo K, Ong SG, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, et al. iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy. Nature Cell Biology. PMID 27642787 DOI: 10.1038/Ncb3411 |
0.774 |
|
| 2016 |
Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, et al. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell. PMID 27545504 DOI: 10.1016/J.Stem.2016.07.006 |
0.765 |
|
| 2016 |
Stillitano F, Turnbull IC, Karakikes I, Nonnenmacher M, Backeris P, Hulot JS, Kranias EG, Hajjar RJ, Costa KD. Genomic correction of familial cardiomyopathy in human engineered cardiac tissues. European Heart Journal. PMID 27450564 DOI: 10.1093/Eurheartj/Ehw307 |
0.301 |
|
| 2015 |
Kuznetsova T, Haddad F, Knez J, Rosenberg-Hasson Y, Sung J, Cauwenberghs N, Thijs L, Karakikes I, Maecker H, Mahaffey KW, Wu JC, Staessen JA. Cytokines profile in hypertensive patients with left ventricular remodeling and dysfunction. Journal of the American Society of Hypertension : Jash. PMID 26565110 DOI: 10.1016/J.Jash.2015.10.003 |
0.385 |
|
| 2015 |
Wilson KD, Shen P, Fung E, Karakikes I, Zhang A, InanlooRahatloo K, Odegaard J, Sallam K, Davis RW, Lui GK, Ashley EA, Scharfe C, Wu JC. A Rapid, High-Quality, Cost-Effective, Comprehensive and Expandable Targeted Next-Generation Sequencing Assay for Inherited Heart Diseases. Circulation Research. 117: 603-11. PMID 26265630 DOI: 10.1161/Circresaha.115.306723 |
0.687 |
|
| 2015 |
Karakikes I, Ameen M, Termglinchan V, Wu JC. Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes. Circulation Research. 117: 80-8. PMID 26089365 DOI: 10.1161/Circresaha.117.305365 |
0.534 |
|
| 2015 |
Rapti K, Stillitano F, Karakikes I, Nonnenmacher M, Weber T, Hulot JS, Hajjar RJ. Effectiveness of gene delivery systems for pluripotent and differentiated cells. Molecular Therapy. Methods & Clinical Development. 2: 14067. PMID 26052535 DOI: 10.1038/mtm.2014.67 |
0.322 |
|
| 2015 |
Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, et al. Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. Nature Communications. 6: 6955. PMID 25923014 DOI: 10.1038/Ncomms7955 |
0.58 |
|
| 2015 |
Chen G, Li S, Karakikes I, Ren L, Chow MZ, Chopra A, Keung W, Yan B, Chan CW, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA. Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs. Circulation. Arrhythmia and Electrophysiology. 8: 193-202. PMID 25504561 DOI: 10.1161/Circep.114.002049 |
0.421 |
|
| 2015 |
Wilson KD, Shen P, Fung E, Karakikes I, Zhang A, InanlooRahatloo K, Odegaard J, Sallam K, Davis RW, Lui GK, Ashley EA, Scharfe C, Wu JC. A Rapid, High-Quality, Cost-Effective, Comprehensive and Expandable Targeted Next-Generation Sequencing Assay for Inherited Heart Diseases Circulation Research. 117: 603-611. DOI: 10.1161/CIRCRESAHA.115.306723 |
0.672 |
|
| 2014 |
Durruthy-Durruthy J, Briggs SF, Awe J, Ramathal CY, Karumbayaram S, Lee PC, Heidmann JD, Clark A, Karakikes I, Loh KM, Wu JC, Hoffman AR, Byrne J, Reijo Pera RA, Sebastiano V. Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions. Plos One. 9: e94231. PMID 24718618 DOI: 10.1371/Journal.Pone.0094231 |
0.462 |
|
| 2014 |
Karakikes I, Termglinchan V, Wu JC. Human-induced pluripotent stem cell models of inherited cardiomyopathies. Current Opinion in Cardiology. 29: 214-9. PMID 24576884 DOI: 10.1097/Hco.0000000000000049 |
0.516 |
|
| 2014 |
Weng Z, Kong CW, Ren L, Karakikes I, Geng L, He J, Chow MZ, Mok CF, Keung W, Chow H, Leung AY, Hajjar RJ, Li RA, Chan CW. A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells. Stem Cells and Development. 23: 1704-16. PMID 24564569 DOI: 10.1089/scd.2013.0509 |
0.365 |
|
| 2014 |
Karakikes I, Senyei GD, Hansen J, Kong CW, Azeloglu EU, Stillitano F, Lieu DK, Wang J, Ren L, Hulot JS, Iyengar R, Li RA, Hajjar RJ. Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes. Stem Cells Translational Medicine. 3: 18-31. PMID 24324277 DOI: 10.5966/Sctm.2013-0110 |
0.428 |
|
| 2014 |
Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee JJ, Xie C, Senyei G, Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot JS, Costa KD. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 644-54. PMID 24174427 DOI: 10.1096/Fj.13-228007 |
0.324 |
|
| 2013 |
Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 34: 8878-86. PMID 23942210 DOI: 10.1016/J.Biomaterials.2013.07.039 |
0.395 |
|
| 2012 |
Stillitano F, Karakikes I, Costa KD, Fish K, Hajjar RJ, Hulot JS. Preclinical animal models for testing iPSC/ESC-based heart therapy Drug Discovery Today: Disease Models. 9. DOI: 10.1016/J.Ddmod.2012.04.004 |
0.315 |
|
| 2011 |
Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD. Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. Journal of Molecular and Cellular Cardiology. 51: 4-15. PMID 21440552 DOI: 10.1016/J.Yjmcc.2011.03.001 |
0.336 |
|
| 2010 |
Galende E, Karakikes I, Edelmann L, Desnick RJ, Kerenyi T, Khoueiry G, Lafferty J, McGinn JT, Brodman M, Fuster V, Hajjar RJ, Polgar K. Amniotic fluid cells are more efficiently reprogrammed to pluripotency than adult cells Cellular Reprogramming. 12: 117-125. PMID 20677926 DOI: 10.1089/Cell.2009.0077 |
0.345 |
|
| 2007 |
Torella D, Ellison GM, Karakikes I, Nadal-Ginard B. Resident cardiac stem cells. Cellular and Molecular Life Sciences : Cmls. 64: 661-73. PMID 17380307 DOI: 10.1007/S00018-007-6519-Y |
0.352 |
|
| 2007 |
Ellison GM, Torella D, Karakikes I, Nadal-Ginard B. Myocyte death and renewal: modern concepts of cardiac cellular homeostasis. Nature Clinical Practice. Cardiovascular Medicine. 4: S52-9. PMID 17230216 DOI: 10.1038/ncpcardio0773 |
0.347 |
|
| 2007 |
Torella D, Ellison GM, Karakikes I, Nadal-Ginard B. Growth-factor-mediated cardiac stem cell activation in myocardial regeneration. Nature Clinical Practice. Cardiovascular Medicine. 4: S46-51. PMID 17230215 DOI: 10.1038/ncpcardio0772 |
0.346 |
|
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