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Wojciech Niedzwiedz, Ph.D. - Publications

Affiliations: 
Institute of Cancer Research, London, UK 
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bland P, Saville H, Wai PT, Curnow L, Muirhead G, Nieminuszczy J, Ravindran N, John MB, Hedayat S, Barker HE, Wright J, Yu L, Mavrommati I, Read A, Peck B, ... ... Niedzwiedz W, et al. SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response. Nature Genetics. PMID 37524790 DOI: 10.1038/s41588-023-01460-5  0.325
2023 Nieminuszczy J, Martin PR, Broderick R, Krwawicz J, Kanellou A, Mocanu C, Bousgouni V, Smith C, Wen KK, Woodward BL, Bakal C, Shackley F, Aguilera A, Stewart GS, Vyas YM, ... Niedzwiedz W, et al. Actin nucleators safeguard replication forks by limiting nascent strand degradation. Nucleic Acids Research. PMID 37224534 DOI: 10.1093/nar/gkad369  0.404
2023 Broderick R, Cherdyntseva V, Nieminuszczy J, Dragona E, Kyriakaki M, Evmorfopoulou T, Gagos S, Niedzwiedz W. Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity. Nature Communications. 14: 2428. PMID 37105990 DOI: 10.1038/s41467-023-38029-z  0.408
2023 Nieminuszczy J, Martin PR, Broderick R, Krwawicz J, Kanellou A, Mocanu C, Bousgouni V, Smith C, Wen KK, Woodward BL, Bakal C, Shackley F, Aguilera A, Stewart GS, Vyas YM, ... Niedzwiedz W, et al. Actin nucleators safeguard replication forks by limiting nascent strand degradation. Biorxiv : the Preprint Server For Biology. PMID 36711944 DOI: 10.1101/2023.01.12.523639  0.403
2023 Sandoz J, Cigrang M, Zachayus A, Catez P, Donnio LM, Elly C, Nieminuszczy J, Berico P, Braun C, Alekseev S, Egly JM, Niedzwiedz W, Giglia-Mari G, Compe E, Coin F. Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress. Nature Communications. 14: 341. PMID 36670096 DOI: 10.1038/s41467-023-35922-5  0.327
2022 Han SS, Wen KK, García-Rubio ML, Wold MS, Aguilera A, Niedzwiedz W, Vyas YM. WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage. Nature Communications. 13: 3743. PMID 35768435 DOI: 10.1038/s41467-022-31415-z  0.473
2020 Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, et al. [SAMHD1 acts at stalled replication forks to prevent interferon induction]. Comptes Rendus Biologies. 343: 9-21. PMID 32720483 DOI: 10.5802/Crbiol.10  0.428
2019 Nieminuszczy J, Broderick R, Bellani MA, Smethurst E, Schwab RA, Cherdyntseva V, Evmorfopoulou T, Lin YL, Minczuk M, Pasero P, Gagos S, Seidman MM, Niedzwiedz W. EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2. Molecular Cell. PMID 31255466 DOI: 10.1016/J.Molcel.2019.05.026  0.456
2018 Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, et al. SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature. PMID 29670289 DOI: 10.1038/S41586-018-0050-1  0.363
2017 Sun L, Huang Y, Edwards RA, Yang S, Blackford AN, Niedzwiedz W, Glover JNM. Structural Insight into BLM Recognition by TopBP1. Structure (London, England : 1993). PMID 28919440 DOI: 10.1016/J.Str.2017.08.005  0.662
2017 Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, Hoffmann JS, Tarsounas M. MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells. Nature Communications. 8: 15983. PMID 28714477 DOI: 10.1038/ncomms15983  0.483
2016 Niedzwiedz W. Activating ATR, the devil's in the dETAA1l. Nature Cell Biology. 18: 1120-1122. PMID 27784903 DOI: 10.1038/ncb3431  0.389
2016 Fenwick AL, Kliszczak M, Cooper F, Murray J, Sanchez-Pulido L, Twigg SR, Goriely A, McGowan SJ, Miller KA, Taylor IB, Logan C, Bozdogan S, Danda S, Dixon J, ... ... Niedzwiedz W, et al. Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis. American Journal of Human Genetics. PMID 27374770 DOI: 10.1016/J.Ajhg.2016.05.019  0.322
2016 Nieminuszczy J, Schwab RA, Niedzwiedz W. The DNA fibre technique - tracking helicases at work. Methods (San Diego, Calif.). 108: 92-8. PMID 27102626 DOI: 10.1016/j.ymeth.2016.04.019  0.453
2016 Broderick R, Nieminuszczy J, Baddock HT, Deshpande RA, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W. EXD2 promotes homologous recombination by facilitating DNA end resection. Nature Cell Biology. PMID 26807646 DOI: 10.1038/Ncb3303  0.44
2015 Schwab RA, Nieminuszczy J, Shah F, Langton J, Lopez Martinez D, Liang CC, Cohn MA, Gibbons RJ, Deans AJ, Niedzwiedz W. The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription. Molecular Cell. 60: 351-61. PMID 26593718 DOI: 10.1016/j.molcel.2015.09.012  0.451
2015 Broderick R, Niedzwiedz W. Sister chromatid decatenation: bridging the gaps in our knowledge. Cell Cycle (Georgetown, Tex.). 14: 3040-4. PMID 26266709 DOI: 10.1080/15384101.2015.1078039  0.334
2015 Higgs MR, Reynolds JJ, Winczura A, Blackford AN, Borel V, Miller ES, Zlatanou A, Nieminuszczy J, Ryan EL, Davies NJ, Stankovic T, Boulton SJ, Niedzwiedz W, Stewart GS. BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks. Molecular Cell. 59: 462-77. PMID 26166705 DOI: 10.1016/j.molcel.2015.06.007  0.695
2015 Blackford AN, Nieminuszczy J, Schwab RA, Galanty Y, Jackson SP, Niedzwiedz W. TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation. Molecular Cell. 57: 1133-41. PMID 25794620 DOI: 10.1016/j.molcel.2015.02.012  0.682
2015 Broderick R, Nieminuszczy J, Blackford AN, Winczura A, Niedzwiedz W. TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution. Nature Communications. 6: 6572. PMID 25762097 DOI: 10.1038/ncomms7572  0.676
2014 Yata K, Bleuyard JY, Nakato R, Ralf C, Katou Y, Schwab RA, Niedzwiedz W, Shirahige K, Esashi F. BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability. Cell Reports. 7: 1547-59. PMID 24835992 DOI: 10.1016/j.celrep.2014.04.023  0.381
2013 Schwab RA, Nieminuszczy J, Shin-ya K, Niedzwiedz W. FANCJ couples replication past natural fork barriers with maintenance of chromatin structure. The Journal of Cell Biology. 201: 33-48. PMID 23530069 DOI: 10.1083/jcb.201208009  0.422
2012 Blackford AN, Schwab RA, Nieminuszczy J, Deans AJ, West SC, Niedzwiedz W. The DNA translocase activity of FANCM protects stalled replication forks. Human Molecular Genetics. 21: 2005-16. PMID 22279085 DOI: 10.1093/Hmg/Dds013  0.706
2011 Schwab RA, Niedzwiedz W. Visualization of DNA replication in the vertebrate model system DT40 using the DNA fiber technique. Journal of Visualized Experiments : Jove. e3255. PMID 22064662 DOI: 10.3791/3255  0.389
2010 Blackford AN, Schwab RA, Niedzwiedz W. A novel ATRibute of FANCM. Cell Cycle (Georgetown, Tex.). 9: 1453-5. PMID 20372056  0.568
2010 Schwab RA, Blackford AN, Niedzwiedz W. ATR activation and replication fork restart are defective in FANCM-deficient cells. The Embo Journal. 29: 806-18. PMID 20057355 DOI: 10.1038/emboj.2009.385  0.709
2009 Rosado IV, Niedzwiedz W, Alpi AF, Patel KJ. The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair. Nucleic Acids Research. 37: 4360-70. PMID 19465393 DOI: 10.1093/nar/gkp365  0.567
2007 Oestergaard VH, Langevin F, Kuiken HJ, Pace P, Niedzwiedz W, Simpson LJ, Ohzeki M, Takata M, Sale JE, Patel KJ. Deubiquitination of FANCD2 is required for DNA crosslink repair. Molecular Cell. 28: 798-809. PMID 18082605 DOI: 10.1016/J.Molcel.2007.09.020  0.555
2005 Mosedale G, Niedzwiedz W, Alpi A, Perrina F, Pereira-Leal JB, Johnson M, Langevin F, Pace P, Patel KJ. The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nature Structural & Molecular Biology. 12: 763-71. PMID 16116434 DOI: 10.1038/Nsmb981  0.601
2005 Niedzwiedz W, Patel KJ. "Dub"bing a tumor suppressor pathway. Cancer Cell. 7: 114-5. PMID 15710323 DOI: 10.1016/j.ccr.2005.01.018  0.58
2004 Niedzwiedz W, Mosedale G, Johnson M, Ong CY, Pace P, Patel KJ. The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Molecular Cell. 15: 607-20. PMID 15327776 DOI: 10.1016/j.molcel.2004.08.009  0.592
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