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Marion Schuller - Publications

Affiliations: 
2018- Oxford University UK 
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Đukić N, Strømland Ø, Elsborg JD, Munnur D, Zhu K, Schuller M, Chatrin C, Kar P, Duma L, Suyari O, Rack JGM, Baretić D, Crudgington DRK, Groslambert J, Fowler G, et al. PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities. Science Advances. 9: eadi2687. PMID 37703374 DOI: 10.1126/sciadv.adi2687  0.642
2023 Schuller M, Raggiaschi R, Mikolcevic P, Rack JGM, Ariza A, Zhang Y, Ledermann R, Tang C, Mikoc A, Ahel I. Molecular basis for the reversible ADP-ribosylation of guanosine bases. Molecular Cell. 83: 2303-2315.e6. PMID 37390817 DOI: 10.1016/j.molcel.2023.06.013  0.669
2023 Suskiewicz MJ, Munnur D, Strømland Ø, Yang JC, Easton LE, Chatrin C, Zhu K, Baretić D, Goffinont S, Schuller M, Wu WF, Elkins JM, Ahel D, Sanyal S, Neuhaus D, et al. Updated protein domain annotation of the PARP protein family sheds new light on biological function. Nucleic Acids Research. PMID 37326024 DOI: 10.1093/nar/gkad514  0.728
2023 Longarini EJ, Dauben H, Locatelli C, Wondisford AR, Smith R, Muench C, Kolvenbach A, Lynskey ML, Pope A, Bonfiglio JJ, Jurado EP, Fajka-Boja R, Colby T, Schuller M, Ahel I, et al. Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Molecular Cell. PMID 37116497 DOI: 10.1016/j.molcel.2023.03.027  0.63
2023 Schuller M, Zarganes-Tzitzikas T, Bennett J, De Cesco S, Fearon D, von Delft F, Fedorov O, Brennan PE, Ahel I. Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors. Pathogens (Basel, Switzerland). 12. PMID 36839595 DOI: 10.3390/pathogens12020324  0.643
2023 Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko DS, Moroz YS, Irwin JJ, Renslo AR, et al. Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America. 120: e2212931120. PMID 36598939 DOI: 10.1073/pnas.2212931120  0.68
2022 Hloušek-Kasun A, Mikolčević P, Rack JGM, Tromans-Coia C, Schuller M, Jankevicius G, Matković M, Bertoša B, Ahel I, Mikoč A. macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA. Computational and Structural Biotechnology Journal. 20: 4337-4350. PMID 36051881 DOI: 10.1016/j.csbj.2022.08.002  0.759
2022 Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko D, Moroz Y, Irwin JJ, Renslo AR, et al. Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 35794891 DOI: 10.1101/2022.06.27.497816  0.646
2022 Schuller M, Ahel I. Beyond protein modification: the rise of non-canonical ADP-ribosylation. The Biochemical Journal. 479: 463-477. PMID 35175282 DOI: 10.1042/BCJ20210280  0.639
2021 Schuller M, Butler RE, Ariza A, Tromans-Coia C, Jankevicius G, Claridge TDW, Kendall SL, Goh S, Stewart GR, Ahel I. Molecular basis for DarT ADP-ribosylation of a DNA base. Nature. PMID 34408320 DOI: 10.1038/s41586-021-03825-4  0.753
2021 Bajusz D, Wade WS, Satała G, Bojarski AJ, Ilaš J, Ebner J, Grebien F, Papp H, Jakab F, Douangamath A, Fearon D, von Delft F, Schuller M, Ahel I, Wakefield A, et al. Exploring protein hotspots by optimized fragment pharmacophores. Nature Communications. 12: 3201. PMID 34045440 DOI: 10.1038/s41467-021-23443-y  0.612
2021 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, et al. Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Science Advances. 7. PMID 33853786 DOI: 10.1126/sciadv.abf8711  0.66
2020 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Martins LC, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, et al. Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking. Biorxiv : the Preprint Server For Biology. PMID 33269349 DOI: 10.1101/2020.11.24.393405  0.663
2020 Rack JGM, Zorzini V, Zhu Z, Schuller M, Ahel D, Ahel I. Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential. Open Biology. 10: 200237. PMID 33202171 DOI: 10.1098/rsob.200237  0.614
2018 Moustakim M, Riedel K, Schuller M, Gehring AP, Monteiro OP, Martin SP, Fedorov O, Heer J, Dixon DJ, Elkins JM, Knapp S, Bracher F, Brennan PE. Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorganic & Medicinal Chemistry. PMID 29567296 DOI: 10.1016/J.Bmc.2018.03.020  0.6
2017 Schuller M, Riedel K, Gibbs-Seymour I, Uth K, Sieg C, Gehring AP, Ahel I, Bracher F, Kessler BM, Elkins JM, Knapp S. Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14. Acs Chemical Biology. PMID 28991428 DOI: 10.1021/Acschembio.7B00445  0.696
2015 Froese DS, Kopec J, Fitzpatrick F, Schuller M, McCorvie TJ, Chalk R, Plessl T, Fettelschoss V, Fowler B, Baumgartner MR, Yue WW. Structural insights into the MMACHC-MMADHC protein complex involved in vitamin B12 trafficking. The Journal of Biological Chemistry. PMID 26483544 DOI: 10.1074/jbc.M115.683268  0.339
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