Rene Maehr - Publications

UMASS Medical School, Worcester, MA, United States 

36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Reis M, Willis GR, Fernandez-Gonzalez A, Yeung V, Taglauer E, Magaletta M, Parsons T, Derr A, Liu X, Maehr R, Kourembanas S, Mitsialis SA. Mesenchymal Stromal Cell-Derived Extracellular Vesicles Restore Thymic Architecture and T Cell Function Disrupted by Neonatal Hyperoxia. Frontiers in Immunology. 12: 640595. PMID 33936055 DOI: 10.3389/fimmu.2021.640595  0.301
2020 Magaletta ME, Siller R, Maehr R. Differentiation of human pluripotent stem cells toward pharyngeal endoderm derivatives: Current status and potential. Current Topics in Developmental Biology. 138: 175-208. PMID 32220297 DOI: 10.1016/bs.ctdb.2020.01.004  0.393
2019 Min SY, Desai A, Yang Z, Sharma A, DeSouza T, Genga RMJ, Kucukural A, Lifshitz LM, Nielsen S, Scheele C, Maehr R, Garber M, Corvera S. Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31420514 DOI: 10.1073/Pnas.1906512116  0.306
2019 Genga RMJ, Kernfeld EM, Parsi KM, Parsons TJ, Ziller MJ, Maehr R. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. Cell Reports. 27: 708-718.e10. PMID 30995470 DOI: 10.1016/j.celrep.2019.03.076  0.372
2018 Kernfeld EM, Genga RMJ, Neherin K, Magaletta ME, Xu P, Maehr R. A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation. Immunity. PMID 29884461 DOI: 10.1016/j.immuni.2018.04.015  0.377
2017 Parsi KM, Hennessy E, Kearns N, Maehr R. Using an Inducible CRISPR-dCas9-KRAB Effector System to Dissect Transcriptional Regulation in Human Embryonic Stem Cells. Methods in Molecular Biology (Clifton, N.J.). 1507: 221-233. PMID 27832543 DOI: 10.1007/978-1-4939-6518-2_16  0.429
2016 Genga RM, Kearns NA, Maehr R. Controlling transcription in human pluripotent stem cells using CRISPR-effectors. Methods (San Diego, Calif.). 101: 36-42. PMID 26525193 DOI: 10.1016/j.ymeth.2015.10.014  0.361
2015 Kearns NA, Pham H, Tabak B, Genga RM, Silverstein NJ, Garber M, Maehr R. Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nature Methods. 12: 401-3. PMID 25775043 DOI: 10.1038/nmeth.3325  0.304
2014 Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA. Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway. Elife. 3: e02809. PMID 25233132 DOI: 10.7554/Elife.02809  0.747
2014 Chen YJ, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R, Dor Y, Li C, Spence JR, Stanger BZ. De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts. Cell Reports. 6: 1046-58. PMID 24613355 DOI: 10.1016/J.Celrep.2014.02.013  0.708
2014 Kearns NA, Genga RM, Enuameh MS, Garber M, Wolfe SA, Maehr R. Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells. Development (Cambridge, England). 141: 219-23. PMID 24346702 DOI: 10.1242/dev.103341  0.415
2014 Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA. Author response: Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway Elife. DOI: 10.7554/Elife.02809.018  0.739
2013 Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells (Dayton, Ohio). 31: 2833-41. PMID 23765749 DOI: 10.1002/Stem.1445  0.683
2011 Sherwood RI, Maehr R, Mazzoni EO, Melton DA. Wnt signaling specifies and patterns intestinal endoderm. Mechanisms of Development. 128: 387-400. PMID 21854845 DOI: 10.1016/J.Mod.2011.07.005  0.724
2010 Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 140: 704-16. PMID 20211139 DOI: 10.1016/J.Cell.2010.01.026  0.341
2010 Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes & Development. 24: 312-26. PMID 20123909 DOI: 10.1101/Gad.1833510  0.756
2009 Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 106: 15768-73. PMID 19720998 DOI: 10.1073/Pnas.0906894106  0.607
2009 Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 4: 348-58. PMID 19341624 DOI: 10.1016/J.Stem.2009.01.014  0.631
2009 Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nature Chemical Biology. 5: 258-65. PMID 19287398 DOI: 10.1038/Nchembio.154  0.631
2008 Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature Biotechnology. 26: 1269-75. PMID 18849973 DOI: 10.1038/Nbt.1502  0.748
2008 Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Plough HL, Barrett TA, Weissleder R, Khazaie K. Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. Plos One. 3: e2916. PMID 18698347 DOI: 10.1371/Journal.Pone.0002916  0.392
2008 Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nature Biotechnology. 26: 795-7. PMID 18568017 DOI: 10.1038/Nbt1418  0.724
2008 Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Barrett TA, Weissleder R, Khazaie K. Correction: Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth Plos One. 3. DOI: 10.1371/annotation/499b225f-e661-4124-aa2f-60bef89bd14a  0.323
2007 Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, Kopito RR. The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. The Embo Journal. 26: 2693-706. PMID 17491588 DOI: 10.1038/Sj.Emboj.7601722  0.474
2007 Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, Ploegh HL. AID-/-μs-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells Journal of Immunology. 178: 2192-2203. PMID 17277124 DOI: 10.4049/Jimmunol.178.4.2192  0.465
2006 Hang HC, Loureiro J, Spooner E, van der Velden AW, Kim YM, Pollington AM, Maehr R, Starnbach MN, Ploegh HL. Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells. Acs Chemical Biology. 1: 713-23. PMID 17184136 DOI: 10.1021/Cb600431A  0.614
2006 Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: Major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines Immunology. 119: 98-115. PMID 16836618 DOI: 10.1111/J.1365-2567.2006.02412.X  0.476
2005 Maehr R, Mintern JD, Herman AE, Lennon-Duménil AM, Mathis D, Benoist C, Ploegh HL. Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. The Journal of Clinical Investigation. 115: 2934-43. PMID 16184198 DOI: 10.1172/Jci25485  0.419
2005 Maehr R, Hang HC, Mintern JD, Kim YM, Cuvillier A, Nishimura M, Yamada K, Shirahama-Noda K, Hara-Nishimura I, Ploegh HL. Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. Journal of Immunology (Baltimore, Md. : 1950). 174: 7066-74. PMID 15905550 DOI: 10.4049/Jimmunol.174.11.7066  0.606
2004 Maehr R, Kraus M, Ploegh HL. Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment. European Journal of Immunology. 34: 2230-6. PMID 15259020 DOI: 10.1002/Eji.200425246  0.417
2004 van Swieten PF, Maehr R, van den Nieuwendijk AM, Kessler BM, Reich M, Wong CS, Kalbacher H, Leeuwenburgh MA, Driessen C, van der Marel GA, Ploegh HL, Overkleeft HS. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 14: 3131-4. PMID 15149659 DOI: 10.1016/J.Bmcl.2004.04.046  0.527
2004 Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation Proceedings of the National Academy of Sciences of the United States of America. 101: 4566-4571. PMID 15070758 DOI: 10.1073/Pnas.0400885101  0.462
2003 Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Molecular & Cellular Proteomics : McP. 2: 1188-97. PMID 13130081 DOI: 10.1074/Mcp.M300067-Mcp200  0.575
2003 Fiebiger E, Maehr R, Villadangos J, Weber E, Erickson A, Bikoff E, Ploegh HL, Lennon-Duménil AM. Invariant chain controls the activity of extracellular cathepsin L. The Journal of Experimental Medicine. 196: 1263-9. PMID 12417635 DOI: 10.1084/jem.20020762  0.392
2002 Vugmeyster Y, Borodovsky A, Maurice MM, Maehr R, Furman MH, Ploegh HL. The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). Molecular Immunology. 39: 431-41. PMID 12413694 DOI: 10.1016/S0161-5890(02)00123-2  0.416
2002 Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C. Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. The Journal of Experimental Medicine. 196: 529-40. PMID 12186844 DOI: 10.1084/jem.20020327  0.597
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