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David E. Clapham - Publications

Affiliations: 
Neurobiology Harvard Medical School/HHMI, Boston, MA, United States 
Area:
Ion channels and calcium signaling
Website:
http://www.fas.harvard.edu/~biophys/David_E_Clapham.htm
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Year Citation  Score
2023 Sheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, ... ... Clapham DE, et al. A Serotonergic Axon-Cilium Synapse Drives Nuclear Signaling to Maintain Chromatin Accessibility. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 29: 1091. PMID 37613506 DOI: 10.1093/micmic/ozad067.561  0.563
2023 Miller AN, Houlihan PR, Matamala E, Cabezas-Bratesco D, Lee GY, Cristofori-Armstrong B, Dilan TL, Sanchez-Martinez S, Matthies D, Yan R, Yu Z, Ren D, Brauchi SE, Clapham DE. The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins. Elife. 12. PMID 36695574 DOI: 10.7554/eLife.84477  0.77
2022 Miller AN, Houlihan PR, Matamala E, Cabezas-Bratesco D, Lee GY, Cristofori-Armstrong B, Dilan TL, Sanchez-Martinez S, Matthies D, Yan R, Yu Z, Ren D, Brauchi SE, Clapham DE. The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins. Biorxiv : the Preprint Server For Biology. PMID 36263072 DOI: 10.1101/2022.09.02.506428  0.77
2022 Sheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, ... ... Clapham DE, et al. A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell. 185: 3390-3407.e18. PMID 36055200 DOI: 10.1016/j.cell.2022.07.026  0.597
2021 Clapham DE, Hulse RE. Sperm CatSper ion channel swims into sharper focus. Nature. PMID 34290412 DOI: 10.1038/d41586-021-01945-5  0.356
2021 Bernal L, Sotelo-Hitschfeld P, König C, Sinica V, Wyatt A, Winter Z, Hein A, Touska F, Reinhardt S, Tragl A, Kusuda R, Wartenberg P, Sclaroff A, Pfeifer JD, Ectors F, ... ... Clapham DE, et al. Odontoblast TRPC5 channels signal cold pain in teeth. Science Advances. 7. PMID 33771873 DOI: 10.1126/sciadv.abf5567  0.631
2021 Liu B, Mundt N, Miller M, Clapham DE, Kirichok Y, Lishko PV. Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells. Journal of Visualized Experiments : Jove. PMID 33645583 DOI: 10.3791/62049  0.697
2020 Gao S, Valinsky WC, On NC, Houlihan PR, Qu Q, Liu L, Pan X, Clapham DE, Yan N. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proceedings of the National Academy of Sciences of the United States of America. PMID 32513729 DOI: 10.1073/pnas.1922903117  0.452
2019 Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, ... ... Clapham DE, et al. Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function. Science Advances. 5: eaaw7935. PMID 31355338 DOI: 10.1126/Sciadv.Aaw7935  0.45
2019 Islas LD, Rohacs T, Clapham DE. Decision letter: Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates Elife. DOI: 10.7554/Elife.44556.028  0.351
2019 Blair NT, Carvacho I, Chaudhuri D, Clapham DE, DeCaen P, Delling M, Doerner JF, Fan L, Ha K, Jordt SE, Julius D, Kahle KT, Liu B, McKemy D, Nilius B, et al. Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f78/2019.4  0.849
2019 Adelman JP, Clapham DE, Hibino H, Inanobe A, Jan LY, Karschin A, Kubo Y, Kurachi Y, Lazdunski M, Miki T, Nichols CG, Palmer LG, Pearson WL, Sackin H, Seino S, et al. Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f74/2019.4  0.354
2019 Chung J, Clapham DE, Garbers DL, Ren D. CatSper and Two-Pore channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f70/2019.4  0.445
2018 Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE. Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. PMID 30108148 DOI: 10.1073/Pnas.1810719115  0.499
2018 Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J. Structure of the mouse TRPC4 ion channel. Nature Communications. 9: 3102. PMID 30082700 DOI: 10.1038/s41467-018-05247-9  0.457
2018 Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE. Cryo-EM structure of the polycystin 2-l1 ion channel. Elife. 7. PMID 30004384 DOI: 10.7554/Elife.36931  0.424
2018 Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE. Structure of full-length human TRPM4. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463718 DOI: 10.1073/pnas.1722038115  0.406
2018 Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE. Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. Elife. 7. PMID 29443690 DOI: 10.7554/Elife.33183  0.491
2018 Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE. Author response: Cryo-EM structure of the polycystin 2-l1 ion channel Elife. DOI: 10.7554/Elife.36931.026  0.402
2017 Krapivinsky G, Krapivinsky L, Renthal NE, Santa-Cruz A, Manasian Y, Clapham DE. Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proceedings of the National Academy of Sciences of the United States of America. PMID 28784805 DOI: 10.1073/pnas.1708427114  0.369
2017 Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE. TRPM7 senses oxidative stress to release Zn(2+) from unique intracellular vesicles. Proceedings of the National Academy of Sciences of the United States of America. PMID 28696294 DOI: 10.1073/Pnas.1707380114  0.347
2017 Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Elife. 6. PMID 28226241 DOI: 10.7554/Elife.23082  0.607
2017 Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SY, Clapham DE, Benavides F, Geha RS. LRRC8A-dependent volume regulated anion channel activity is dispensable for T cell development and function. The Journal of Allergy and Clinical Immunology. PMID 28192143 DOI: 10.1016/J.Jaci.2016.12.974  0.368
2017 Chung J, Miki K, Kim D, Shim S, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. Author response: CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility Elife. DOI: 10.7554/Elife.23082.032  0.664
2016 Pablo JL, DeCaen PG, Clapham DE. Progress in ciliary ion channel physiology. The Journal of General Physiology. PMID 27999145 DOI: 10.1085/Jgp.201611696  0.46
2016 Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 167: 763-773.e11. PMID 27768895 DOI: 10.1016/J.Cell.2016.09.048  0.461
2016 DeCaen PG, Liu X, Abiria S, Clapham DE. Atypical calcium regulation of the PKD2-L1 polycystin ion channel. Elife. 5. PMID 27348301 DOI: 10.7554/Elife.13413  0.481
2016 Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. Primary cilia are not calcium-responsive mechanosensors. Nature. PMID 27007841 DOI: 10.1038/Nature17426  0.351
2016 Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976564 DOI: 10.1073/Pnas.1602264113  0.336
2016 Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA. Molecular basis of ion permeability in a voltage-gated sodium channel. The Embo Journal. PMID 26873592 DOI: 10.15252/Embj.201593285  0.478
2016 Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE. Naturally Produced Defensive Alkenal Compounds Activate TRPA1. Chemical Senses. PMID 26843529 DOI: 10.1093/Chemse/Bjv071  0.781
2016 DeCaen PG, Liu X, Abiria S, Clapham DE. Author response: Atypical calcium regulation of the PKD2-L1 polycystin ion channel Elife. DOI: 10.7554/Elife.13413.021  0.415
2016 Sula A, DeCaen P, Naylor C, Zanatta G, Bagneris C, Clapham DE, Pryde D, Wallace B. Sodium Channel/Ligand Complex Structures as a Guide for Rational Drug Design Biophysical Journal. 110: 33a. DOI: 10.1016/J.Bpj.2015.11.248  0.462
2015 Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. Acs Chemical Biology. PMID 26674547 DOI: 10.1021/Acschembio.5B00748  0.45
2015 Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia. Elife. 4. PMID 26650848 DOI: 10.7554/eLife.11066  0.473
2015 Clapham DE. Structural biology: Pain-sensing TRPA1 channel resolved. Nature. 520: 439-41. PMID 25855290 DOI: 10.1038/nature14383  0.397
2015 Cai X, Wang X, Patel S, Clapham DE. Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium. 57: 166-73. PMID 25498309 DOI: 10.1016/j.ceca.2014.11.007  0.372
2015 Doerner JF, Delling M, Clapham DE. Author response: Ion channels and calcium signaling in motile cilia Elife. DOI: 10.7554/Elife.11066.015  0.428
2015 Naylor CE, Bagneris C, DeCaen PG, Clapham DE, Wallace B. Sodium Ion Coordination in the Selectivity Filter of a Voltage-Gated Sodium Channel Biophysical Journal. 108: 490a. DOI: 10.1016/J.Bpj.2014.11.2681  0.481
2014 DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus. Elife. 3. PMID 25385530 DOI: 10.7554/Elife.04387  0.497
2014 Cai X, Wang X, Clapham DE. Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex. Molecular Biology and Evolution. 31: 2735-40. PMID 25063443 DOI: 10.1093/molbev/msu218  0.36
2014 Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE. The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell. 157: 1061-72. PMID 24855944 DOI: 10.1016/j.cell.2014.03.046  0.417
2014 Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proceedings of the National Academy of Sciences of the United States of America. 111: 8428-33. PMID 24850863 DOI: 10.1073/Pnas.1406855111  0.482
2014 Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 157: 808-22. PMID 24813608 DOI: 10.1016/J.Cell.2014.02.056  0.421
2014 Chaudhuri D, Clapham DE. Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter. Biochemical and Biophysical Research Communications. 449: 367-9. PMID 24792175 DOI: 10.1016/J.Bbrc.2014.04.141  0.374
2014 Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1β release through degradation of TRPC1. Cell Reports. 6: 1122-8. PMID 24630989 DOI: 10.1016/J.Celrep.2014.02.015  0.315
2014 Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. Jama Neurology. 71: 640-5. PMID 24615367 DOI: 10.1001/Jamaneurol.2014.21  0.5
2014 Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3653-67. PMID 24599464 DOI: 10.1523/Jneurosci.2274-13.2014  0.417
2014 Tsai MF, Jiang D, Zhao L, Clapham D, Miller C. Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1. The Journal of General Physiology. 143: 67-73. PMID 24344246 DOI: 10.1085/jgp.201311096  0.323
2014 DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE. Author response: Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus Elife. DOI: 10.7554/Elife.04387.019  0.412
2014 Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity Neurosurgery. 61: 214. DOI: 10.1227/01.Neu.0000452440.75411.82  0.681
2014 DeCaen PG, Delling M, Vien TN, Clapham DE. Corrigendum: Direct recording and molecular identification of the calcium channel of primary cilia Nature. 513: 266. DOI: 10.1038/Nature13631  0.421
2014 Bagnéris C, Naylor CE, DeCaen PG, Clapham DE, Pryde D, Wallace B. Structure/Function Insights into Eukaryotic Channel Blocker Binding Sites in a Prokaryotic Sodium Channel Biophysical Journal. 106: 36a. DOI: 10.1016/J.Bpj.2013.11.273  0.48
2014 Shim S, Chung J, Zhuang X, Clapham DE. Structurally Distinct Ca2+ Domains of Sperm Flagella Modulate Hyperactivated Motility Biophysical Journal. 106: 436a. DOI: 10.1016/J.Bpj.2013.11.2454  0.719
2013 DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 504: 315-8. PMID 24336289 DOI: 10.1038/Nature12832  0.503
2013 Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 504: 311-4. PMID 24336288 DOI: 10.1038/Nature12833  0.411
2013 Carvacho I, Lee HC, Fissore RA, Clapham DE. TRPV3 channels mediate strontium-induced mouse-egg activation. Cell Reports. 5: 1375-86. PMID 24316078 DOI: 10.1016/J.Celrep.2013.11.007  0.463
2013 Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science (New York, N.Y.). 342: 1379-82. PMID 24231807 DOI: 10.1126/Science.1242993  0.368
2013 Clapham DE. Sperm BerserKers. Elife. 2: e01469. PMID 24137547 DOI: 10.7554/eLife.01469  0.449
2013 Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nature Communications. 4: 2465. PMID 24051986 DOI: 10.1038/Ncomms3465  0.427
2013 Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. The Journal of General Physiology. 142: 305-13. PMID 23980198 DOI: 10.1085/jgp.201311011  0.408
2013 Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proceedings of the National Academy of Sciences of the United States of America. 110: E3037-46. PMID 23878236 DOI: 10.1073/Pnas.1311865110  0.399
2013 Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME. The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. The Journal of General Physiology. 142: 113-26. PMID 23858001 DOI: 10.1085/Jgp.201310996  0.617
2013 Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. MCU encodes the pore conducting mitochondrial calcium currents. Elife. 2: e00704. PMID 23755363 DOI: 10.7554/Elife.00704  0.44
2013 Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation. 128: 101-14. PMID 23734001 DOI: 10.1161/Circulationaha.112.000768  0.597
2013 Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 6364-9. PMID 23542377 DOI: 10.1073/Pnas.1214667110  0.501
2013 Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. Methods in Enzymology. 525: 59-83. PMID 23522465 DOI: 10.1016/B978-0-12-397944-5.00004-3  0.749
2013 Miki K, Clapham DE. Rheotaxis guides mammalian sperm. Current Biology : Cb. 23: 443-52. PMID 23453951 DOI: 10.1016/j.cub.2013.02.007  0.327
2013 Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 152: 778-90. PMID 23394946 DOI: 10.1016/J.Cell.2013.01.023  0.749
2013 Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, DeCaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Research. 23: 409-22. PMID 23247626 DOI: 10.1038/Cr.2012.173  0.475
2013 Chung J, Shim S, Zhuang X, Clapham DE. Catsper Channel Organizes and Regulates Calcium Signaling Molecules in Spermatozoa Biophysical Journal. 104: 633a. DOI: 10.1016/J.Bpj.2012.11.3501  0.47
2013 Sah R, Mesirca P, Mason X, Van den Boogert M, Bates-Withers C, Rosen J, Mably J, Mangoni M, Clapham DE. The Ion Channel-Kinase, TRPM7, is Required for Cardiac Automaticity Biophysical Journal. 104: 379a. DOI: 10.1016/J.Bpj.2012.11.2109  0.416
2012 Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 151: 372-83. PMID 23063126 DOI: 10.1016/J.Cell.2012.08.036  0.812
2012 Stotz SC, Clapham DE. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. Plos One. 7: e46865. PMID 23056495 DOI: 10.1371/Journal.Pone.0046865  0.491
2012 Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, ... ... Clapham DE, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 151: 96-110. PMID 23021218 DOI: 10.1016/J.Cell.2012.08.034  0.309
2012 Doerner JF, Febvay S, Clapham DE. Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. Nature Communications. 3: 990. PMID 22871809 DOI: 10.1038/ncomms1999  0.422
2012 Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Developmental Cell. 22: 1149-62. PMID 22698280 DOI: 10.1016/J.Devcel.2012.04.006  0.705
2012 Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 486: 130-4. PMID 22678295 DOI: 10.1038/Nature11054  0.471
2012 Kaczmarek JS, Riccio A, Clapham DE. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proceedings of the National Academy of Sciences of the United States of America. 109: 7888-92. PMID 22547824 DOI: 10.1073/pnas.1205869109  0.8
2012 Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nature Neuroscience. 15: 565-73. PMID 22388960 DOI: 10.1038/Nn.3059  0.518
2012 Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. The channel kinase, TRPM7, is required for early embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 109: E225-33. PMID 22203997 DOI: 10.1073/Pnas.1120033109  0.551
2012 Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annual Review of Physiology. 74: 453-75. PMID 22017176 DOI: 10.1146/Annurev-Physiol-020911-153258  0.831
2012 Cai X, Clapham DE. Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Molecular Biology and Evolution. 29: 91-100. PMID 21680871 DOI: 10.1093/molbev/msr149  0.33
2012 Wang X, Zhang X, Dong X, Samie M, Li X, Shen D, Cheng X, Goschka A, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. Novel Na+-Selective Channels in the Lysosome Biophysical Journal. 102: 105a. DOI: 10.1016/J.Bpj.2011.11.590  0.774
2012 Chung J, Shim S, Zhuang X, Clapham DE. Super-Resolution Imaging Reveals a Multi-Array Arrangement of Catsper Channel on the Sperm Tail Biophysical Journal. 102: 681a. DOI: 10.1016/J.Bpj.2011.11.3702  0.745
2012 Stotz SC, Keating MB, Clapham DE. Drosophila Bestrophin 1 is a Swell Activated Chloride Channel Biophysical Journal. 102: 550a. DOI: 10.1016/J.Bpj.2011.11.2999  0.522
2012 Sah R, Bates-Withers C, Mason X, Van den Boogert M, Gibson W, Jin J, Pu W, Clapham DE. Cardiac-Targeted TRPM7 Deletion Induces Heart Block and Cardiomyopathy via Disrupted Embryonic Ventricular Development Biophysical Journal. 102: 344a. DOI: 10.1016/J.Bpj.2011.11.1884  0.304
2012 Miller C, Clapham DE. A Thermodynamic Framework for Understanding Temperature-Sensitivity in TRP Channels Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.152  0.37
2011 Clapham DE, Miller C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. Proceedings of the National Academy of Sciences of the United States of America. 108: 19492-7. PMID 22109551 DOI: 10.1073/Pnas.1117485108  0.442
2011 Krapivinsky G, Krapivinsky L, Stotz SC, Manasian Y, Clapham DE. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proceedings of the National Academy of Sciences of the United States of America. 108: 19234-9. PMID 22084111 DOI: 10.1073/Pnas.1117231108  0.358
2011 Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, et al. Melanopsin signalling in mammalian iris and retina. Nature. 479: 67-73. PMID 22051675 DOI: 10.1038/Nature10567  0.305
2011 Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proceedings of the National Academy of Sciences of the United States of America. 108: 18114-9. PMID 22025699 DOI: 10.1073/Pnas.1115387108  0.821
2011 Navarro B, Miki K, Clapham DE. ATP-activated P2X2 current in mouse spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. 108: 14342-7. PMID 21831833 DOI: 10.1073/pnas.1111695108  0.491
2011 Bates-Withers C, Sah R, Clapham DE. TRPM7, the Mg(2+) inhibited channel and kinase. Advances in Experimental Medicine and Biology. 704: 173-83. PMID 21290295 DOI: 10.1007/978-94-007-0265-3_9  0.402
2011 Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nature Communications. 2: 153. PMID 21224844 DOI: 10.1038/Ncomms1153  0.533
2011 Wickman K, Hedin KE, Perez‐Terzic CM, Krapivinsky GB, Stehno‐Bittel L, Velimirovic B, Clapham DE. Mechanisms of Transmembrane Signaling Comprehensive Physiology. 689-742. DOI: 10.1002/Cphy.Cp140118  0.569
2010 Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacological Reviews. 62: 381-404. PMID 20716668 DOI: 10.1124/pr.110.002725  0.679
2010 Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MS, Clapham DE. An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. Nature Structural & Molecular Biology. 17: 869-75. PMID 20543828 DOI: 10.1038/Nsmb.1826  0.664
2010 Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, ... Clapham DE, et al. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 141: 331-43. PMID 20403327 DOI: 10.1016/J.Cell.2010.03.013  0.576
2010 Carvacho I, Ramsey IS, Clapham DE. A Single S4 Arginine is Sufficient for Voltage Sensitivity in the Hv1 Proton Channel Biophysical Journal. 98: 622a. DOI: 10.1016/J.BPJ.2009.12.3403  0.659
2010 Clapham DE. Transient receptor potential (TRP) channels Encyclopedia of Neuroscience. 1109-1133. DOI: 10.1016/B978-008045046-9.01634-X  0.355
2009 Jiang D, Zhao L, Clapham DE. Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science (New York, N.Y.). 326: 144-7. PMID 19797662 DOI: 10.1126/science.1175145  0.341
2009 Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 137: 761-72. PMID 19450521 DOI: 10.1016/J.Cell.2009.03.039  0.404
2009 Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. Science Signaling. 2: ra21. PMID 19436059 DOI: 10.1126/Scisignal.2000146  0.821
2009 Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. The Journal of General Physiology. 133: 525-46. PMID 19398778 DOI: 10.1085/jgp.200810153  0.817
2009 Ramsey IS, Ruchti E, Kaczmarek JS, Clapham DE. Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proceedings of the National Academy of Sciences of the United States of America. 106: 7642-7. PMID 19372380 DOI: 10.1073/pnas.0902761106  0.798
2009 Clapham DE. A STIMulus Package puts orai calcium channels to work. Cell. 136: 814-6. PMID 19269360 DOI: 10.1016/j.cell.2009.02.022  0.43
2009 Zimmermann K, Hein A, Hager U, Kaczmarek JS, Turnquist BP, Clapham DE, Reeh PW. Phenotyping sensory nerve endings in vitro in the mouse. Nature Protocols. 4: 174-96. PMID 19180088 DOI: 10.1038/Nprot.2008.223  0.758
2009 Ramsey IS, Carvacho I, Mokrab Y, Sansom MS, Clapham DE. H+ Permeation in Hv1 Voltage-gated Proton Channels Biophysical Journal. 96: 661a. DOI: 10.1016/J.Bpj.2008.12.3495  0.692
2009 Carvacho I, Ramsey IS, Clapham DE. Voltage and proton gradient sensing in Hv1 proton channels Biophysical Journal. 96: 484a. DOI: 10.1016/J.BPJ.2008.12.2495  0.708
2008 Cai X, Clapham DE. Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. Plos One. 3: e3569. PMID 18974790 DOI: 10.1371/journal.pone.0003569  0.494
2008 Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (New York, N.Y.). 322: 756-60. PMID 18974357 DOI: 10.1126/Science.1163493  0.383
2008 Navarro B, Kirichok Y, Chung JJ, Clapham DE. Ion channels that control fertility in mammalian spermatozoa. The International Journal of Developmental Biology. 52: 607-13. PMID 18649274 DOI: 10.1387/Ijdb.072554Bn  0.766
2008 Brauchi S, Krapivinsky G, Krapivinsky L, Clapham DE. TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America. 105: 8304-8. PMID 18539771 DOI: 10.1073/pnas.0800881105  0.692
2008 Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. Plos One. 3: e2082. PMID 18461159 DOI: 10.1371/Journal.Pone.0002082  0.491
2008 Rama S, Krapivinsky G, Clapham DE, Medina I. The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. Molecular and Cellular Neurosciences. 38: 183-8. PMID 18417361 DOI: 10.1016/j.mcn.2008.02.007  0.3
2008 Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE. Detailed comparison of expressed and native voltage-gated proton channel currents. The Journal of Physiology. 586: 2477-86. PMID 18356202 DOI: 10.1113/jphysiol.2007.149427  0.706
2008 Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Correction: Citral Sensing by Transient Receptor Potential Channels in Dorsal Root Ganglion Neurons Plos One. 3. DOI: 10.1371/Annotation/6Ba8E9D9-0035-405E-A7C7-45Ee22B2E381  0.401
2007 Fujinami S, Sato T, Trimmer JS, Spiller BW, Clapham DE, Krulwich TA, Kawagishi I, Ito M. The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. Microbiology (Reading, England). 153: 4027-38. PMID 18048917 DOI: 10.1099/Mic.0.2007/012070-0  0.383
2007 Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 18321-6. PMID 17989217 DOI: 10.1073/Pnas.0709096104  0.61
2007 Liu J, Xia J, Cho KH, Clapham DE, Ren D. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. The Journal of Biological Chemistry. 282: 18945-52. PMID 17478420 DOI: 10.1074/Jbc.M701083200  0.76
2007 Navarro B, Kirichok Y, Clapham DE. KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proceedings of the National Academy of Sciences of the United States of America. 104: 7688-92. PMID 17460039 DOI: 10.1073/Pnas.0702018104  0.694
2007 Clapham DE. SnapShot: mammalian TRP channels. Cell. 129: 220. PMID 17418797 DOI: 10.1016/j.cell.2007.03.034  0.487
2007 Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proceedings of the National Academy of Sciences of the United States of America. 104: 1219-23. PMID 17227845 DOI: 10.1073/Pnas.0610286104  0.821
2006 Krapivinsky G, Mochida S, Krapivinsky L, Cibulsky SM, Clapham DE. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron. 52: 485-96. PMID 17088214 DOI: 10.1016/j.neuron.2006.09.033  0.396
2006 Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. The Journal of Biological Chemistry. 281: 29897-904. PMID 16899456 DOI: 10.1074/Jbc.M605394200  0.469
2006 Lambers TT, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ. Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. The Embo Journal. 25: 2978-88. PMID 16763551 DOI: 10.1038/Sj.Emboj.7601186  0.691
2006 Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. The Journal of Biological Chemistry. 281: 22085-91. PMID 16754686 DOI: 10.1074/Jbc.M603316200  0.334
2006 Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nature Neuroscience. 9: 628-35. PMID 16617338 DOI: 10.1038/Nn1692  0.45
2006 Ramsey IS, Moran MM, Chong JA, Clapham DE. A voltage-gated proton-selective channel lacking the pore domain. Nature. 440: 1213-6. PMID 16554753 DOI: 10.1038/Nature04700  0.807
2006 Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 439: 737-40. PMID 16467839 DOI: 10.1038/Nature04417  0.772
2006 Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annual Review of Physiology. 68: 619-47. PMID 16460286 DOI: 10.1146/annurev.physiol.68.040204.100431  0.742
2006 Oancea E, Wolfe JT, Clapham DE. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circulation Research. 98: 245-53. PMID 16357306 DOI: 10.1161/01.Res.0000200179.29375.Cc  0.688
2005 Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacological Reviews. 57: 509-26. PMID 16382105 DOI: 10.1124/Pr.57.4.11  0.467
2005 Clapham DE, Garbers DL. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. Pharmacological Reviews. 57: 451-4. PMID 16382101 DOI: 10.1124/pr.57.4.7  0.463
2005 Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacological Reviews. 57: 427-50. PMID 16382100 DOI: 10.1124/Pr.57.4.6  0.486
2005 Xu H, Blair NT, Clapham DE. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8924-37. PMID 16192383 DOI: 10.1523/Jneurosci.2574-05.2005  0.811
2005 Desai BN, Clapham DE. TRP channels and mice deficient in TRP channels. Pflã¼Gers Archiv : European Journal of Physiology. 451: 11-8. PMID 16078044 DOI: 10.1007/S00424-005-1429-Z  0.511
2005 Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, ... ... Clapham DE, et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nature Genetics. 37: 739-44. PMID 15924139 DOI: 10.1038/Ng1592  0.413
2005 Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Molecular and Cellular Biology. 25: 2632-43. PMID 15767669 DOI: 10.1128/Mcb.25.7.2632-2643.2005  0.763
2005 Moore JE, Runnels LW, Greka A, Navarro B, Clapham DE. 225 THE CALCIUM-PERMEABLE ION CHANNEL TRPM7 MAY PLAY A ROLE IN CELL MOTILITY AND WOUND REPAIR IN RAT CARDIAC FIBROBASTS Journal of Investigative Medicine. 53: S292.4-S292. DOI: 10.2310/6650.2005.00006.224  0.664
2004 Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron. 43: 563-74. PMID 15312654 DOI: 10.1016/j.neuron.2004.08.003  0.312
2004 Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nature Cell Biology. 6: 709-20. PMID 15258588 DOI: 10.1038/Ncb1150  0.843
2004 Ito M, Xu H, Guffanti AA, Wei Y, Zvi L, Clapham DE, Krulwich TA. The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proceedings of the National Academy of Sciences of the United States of America. 101: 10566-71. PMID 15243157 DOI: 10.1073/Pnas.0402692101  0.436
2004 Moran MM, Xu H, Clapham DE. TRP ion channels in the nervous system. Current Opinion in Neurobiology. 14: 362-9. PMID 15194117 DOI: 10.1016/J.Conb.2004.05.003  0.732
2004 Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. Plos Biology. 2: E50. PMID 15024413 DOI: 10.1371/Journal.Pbio.0020050  0.576
2004 Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 427: 360-4. PMID 14737170 DOI: 10.1038/Nature02246  0.73
2004 Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE. A superfamily of voltage-gated sodium channels in bacteria. The Journal of Biological Chemistry. 279: 9532-8. PMID 14665618 DOI: 10.1074/Jbc.M313100200  0.718
2004 Bezzerides VJ, Clapham DE. Near membrane protein dynamics revealed by evanescent field microscopy Proceedings of Spie - the International Society For Optical Engineering. 5467: 326-337. DOI: 10.1117/12.548399  0.62
2004 Khositseth A, Clapham DE, Ackerman MJ. Intracellular Signaling and Regulation of Cardiac Ion Channels Cardiac Electrophysiology: Fourth Edition. 33-41. DOI: 10.1016/B0-7216-0323-8/50007-5  0.333
2003 Clapham DE, Montell C, Schultz G, Julius D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacological Reviews. 55: 591-6. PMID 14657417 DOI: 10.1124/Pr.55.4.6  0.522
2003 Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Reviews. 55: 583-6. PMID 14657415 DOI: 10.1124/Pr.55.4.9  0.494
2003 Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proceedings of the National Academy of Sciences of the United States of America. 100: 14864-8. PMID 14657352 DOI: 10.1073/Pnas.2536658100  0.753
2003 Clapham DE. TRP channels as cellular sensors. Nature. 426: 517-24. PMID 14654832 DOI: 10.1038/nature02196  0.394
2003 Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron. 40: 775-84. PMID 14622581 DOI: 10.1016/S0896-6273(03)00645-7  0.314
2003 Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nature Neuroscience. 6: 837-45. PMID 12858178 DOI: 10.1038/Nn1092  0.817
2003 Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. The Journal of Biological Chemistry. 278: 39014-9. PMID 12857742 DOI: 10.1074/jbc.M306705200  0.48
2003 Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. Developmental Cell. 4: 561-74. PMID 12689594 DOI: 10.1016/S1534-5807(03)00087-X  0.785
2003 Catterall WA, Chandy KG, Clapham DE, Gutman GA, Hofmann F, Harmar AJ, Abernethy DR, Spedding M. International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels Pharmacological Reviews. 55: 573-574. DOI: 10.1124/Pr.55.4.5  0.449
2002 Yue L, Navarro B, Ren D, Ramos A, Clapham DE. The cation selectivity filter of the bacterial sodium channel, NaChBac. The Journal of General Physiology. 120: 845-53. PMID 12451053 DOI: 10.1085/Jgp.20028699  0.773
2002 Clapham DE. Sorting out MIC, TRP, and CRAC ion channels. The Journal of General Physiology. 120: 217-20. PMID 12149282 DOI: 10.1085/jgp.20028618  0.509
2002 Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 418: 181-6. PMID 12077604 DOI: 10.1038/Nature00882  0.806
2002 Runnels LW, Yue L, Clapham DE. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nature Cell Biology. 4: 329-36. PMID 11941371 DOI: 10.1038/Ncb781  0.628
2002 Clapham DE. Signal transduction. Hot and cold TRP ion channels. Science (New York, N.Y.). 295: 2228-9. PMID 11910099 DOI: 10.1126/science.1070766  0.473
2002 Wickman K, Pu WT, Clapham DE. Structural characterization of the mouse Girk genes. Gene. 284: 241-50. PMID 11891065 DOI: 10.1016/S0378-1119(01)00884-8  0.746
2002 Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, et al. A unified nomenclature for the superfamily of TRP cation channels. Molecular Cell. 9: 229-31. PMID 11864597 DOI: 10.1016/S1097-2765(02)00448-3  0.671
2001 Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE. A prokaryotic voltage-gated sodium channel. Science (New York, N.Y.). 294: 2372-5. PMID 11743207 DOI: 10.1126/Science.1065635  0.794
2001 Quill TA, Ren D, Clapham DE, Garbers DL. A voltage-gated ion channel expressed specifically in spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. 98: 12527-31. PMID 11675491 DOI: 10.1073/Pnas.221454998  0.769
2001 Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature. 413: 603-9. PMID 11595941 DOI: 10.1038/35098027  0.722
2001 Kovoor P, Wickman K, Maguire CT, Pu W, Gehrmann J, Berul CI, Clapham DE. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. Journal of the American College of Cardiology. 37: 2136-43. PMID 11419900 DOI: 10.1016/S0735-1097(01)01304-3  0.545
2001 Clapham DE, Runnels LW, Strübing C. The TRP ion channel family. Nature Reviews. Neuroscience. 2: 387-96. PMID 11389472 DOI: 10.1038/35077544  0.525
2001 Hsu Sf, O'Connell PJ, Klyachko VA, Badminton MN, Thomson AW, Jackson MB, Clapham DE, Ahern GP. Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. Journal of Immunology (Baltimore, Md. : 1950). 166: 6126-33. PMID 11342632 DOI: 10.4049/Jimmunol.166.10.6126  0.358
2001 Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron. 29: 645-55. PMID 11301024 DOI: 10.1016/S0896-6273(01)00240-9  0.526
2001 Yue L, Peng JB, Hediger MA, Clapham DE. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature. 410: 705-9. PMID 11287959 DOI: 10.1038/35070596  0.632
2001 Clapham D. How to lose your hippocampus by working on chloride channels. Neuron. 29: 1-3. PMID 11182073 DOI: 10.1016/S0896-6273(01)00172-6  0.452
2001 Runnels LW, Yue L, Clapham DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science (New York, N.Y.). 291: 1043-7. PMID 11161216 DOI: 10.1126/Science.1058519  0.633
2001 Corey S, Clapham DE. The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs). The Journal of Biological Chemistry. 276: 11409-13. PMID 11148218 DOI: 10.1074/jbc.M100058200  0.495
2000 Jelacic TM, Kennedy ME, Wickman K, Clapham DE. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. The Journal of Biological Chemistry. 275: 36211-6. PMID 10956667 DOI: 10.1074/Jbc.M007087200  0.7
2000 Wickman K, Karschin C, Karschin A, Picciotto MR, Clapham DE. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5608-15. PMID 10908597 DOI: 10.1523/Jneurosci.20-15-05608.2000  0.64
2000 Medina I, Krapivinsky G, Arnold S, Kovoor P, Krapivinsky L, Clapham DE. A switch mechanism for G beta gamma activation of I(KACh). The Journal of Biological Chemistry. 275: 29709-16. PMID 10900209 DOI: 10.1074/jbc.M004989200  0.471
2000 Franco-Obregón A, Wang HW, Clapham DE. Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines. Biophysical Journal. 79: 202-14. PMID 10866948 DOI: 10.1016/S0006-3495(00)76284-9  0.485
2000 Pu WT, Wickman K, Clapham DE. ICln is essential for cellular and early embryonic viability. The Journal of Biological Chemistry. 275: 12363-6. PMID 10777517 DOI: 10.1074/jbc.275.17.12363  0.582
2000 Clapham DE. Remembering Eva Neer Cell. 101: 247-248. DOI: 10.1016/S0092-8674(02)71135-5  0.381
1999 Clapham DE. More pieces of the K+ ion channel puzzle. Nature Structural Biology. 6: 807-10. PMID 10467088 DOI: 10.1038/12261  0.462
1999 Wickman K, Krapivinsky G, Corey S, Kennedy M, Nemec J, Medina I, Clapham DE. Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. Annals of the New York Academy of Sciences. 868: 386-98. PMID 10414308 DOI: 10.1111/j.1749-6632.1999.tb11300.x  0.66
1999 Arnold DB, Clapham DE. Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. Neuron. 23: 149-57. PMID 10402201 DOI: 10.1016/S0896-6273(00)80761-8  0.395
1999 Wang H, Clapham DE. Conformational changes of the in situ nuclear pore complex. Biophysical Journal. 77: 241-7. PMID 10388753 DOI: 10.1016/S0006-3495(99)76885-2  0.327
1999 Clapham DE. Unlocking family secrets: K+ channel transmembrane domains. Cell. 97: 547-50. PMID 10367883 DOI: 10.1016/S0092-8674(00)80765-5  0.439
1999 Jelacic TM, Sims SM, Clapham DE. Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. The Journal of Membrane Biology. 169: 123-9. PMID 10341034 DOI: 10.1007/s002329900524  0.514
1999 Strübing C, Clapham DE. Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells. The Journal of General Physiology. 113: 239-48. PMID 9925822 DOI: 10.1085/jgp.113.2.239  0.352
1999 Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE. GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. The Journal of Biological Chemistry. 274: 2571-82. PMID 9891030 DOI: 10.1074/Jbc.274.4.2571  0.661
1999 Nemec J, Wickman K, Clapham DE. Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. Biophysical Journal. 76: 246-52. PMID 9876138 DOI: 10.1016/S0006-3495(99)77193-6  0.691
1999 Navarro B, Corey S, Kennedy M, Clapham DE. Chapter 16 G-Protein-Gated Potassium Channels: Implication for the weaver Mouse Current Topics in Membranes and Transport. 46: 295-320. DOI: 10.1016/S0070-2161(08)60932-6  0.403
1998 Schiller J, Schiller Y, Clapham DE. NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. Nature Neuroscience. 1: 114-8. PMID 10195125 DOI: 10.1038/363  0.347
1998 Franco-Obregón A, Clapham DE. Touch channels sense blood pressure. Neuron. 21: 1224-6. PMID 9883713 DOI: 10.1016/S0896-6273(00)80639-X  0.371
1998 Corey S, Clapham DE. Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. The Journal of Biological Chemistry. 273: 27499-504. PMID 9765280 DOI: 10.1074/jbc.273.42.27499  0.486
1998 Clapham DE. Not so funny anymore: pacing channels are cloned. Neuron. 21: 5-7. PMID 9697846 DOI: 10.1016/S0896-6273(00)80508-5  0.476
1998 Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE. Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. The Journal of Biological Chemistry. 273: 16946-52. PMID 9642257 DOI: 10.1074/jbc.273.27.16946  0.406
1998 Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE. A novel inward rectifier K+ channel with unique pore properties. Neuron. 20: 995-1005. PMID 9620703 DOI: 10.1016/S0896-6273(00)80480-8  0.498
1998 Lee MA, Dunn RC, Clapham DE, Stehno-Bittel L. Calcium regulation of nuclear pore permeability. Cell Calcium. 23: 91-101. PMID 9601604 DOI: 10.1016/S0143-4160(98)90107-5  0.327
1998 Clapham DE. At last, the structure of an ion-selective channel. Nature Structural Biology. 5: 342-4. PMID 9586991 DOI: 10.1038/nsb0598-342  0.41
1998 Clapham DE. The list of potential volume-sensitive chloride currents continues to swell (and shrink). The Journal of General Physiology. 111: 623-4. PMID 9565400 DOI: 10.1085/jgp.111.5.623  0.496
1998 Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. The Journal of Biological Chemistry. 273: 10811-4. PMID 9556550 DOI: 10.1074/Jbc.273.18.10811  0.598
1998 Lorenz E, Alekseev AE, Krapivinsky GB, Carrasco AJ, Clapham DE, Terzic A. Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel. Molecular and Cellular Biology. 18: 1652-9. PMID 9488482 DOI: 10.1128/Mcb.18.3.1652  0.5
1998 Corey S, Krapivinsky G, Krapivinsky L, Clapham DE. Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. The Journal of Biological Chemistry. 273: 5271-8. PMID 9478984 DOI: 10.1074/jbc.273.9.5271  0.461
1998 Wickman K, Nemec J, Gendler SJ, Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron. 20: 103-14. PMID 9459446 DOI: 10.1016/S0896-6273(00)80438-9  0.599
1997 Clapham DE. The molecular control of cardiac ion channels. Heart and Vessels. 168-9. PMID 9476572  0.332
1997 Clapham DE. Some like it hot: spicing up ion channels. Nature. 389: 783-4. PMID 9349801 DOI: 10.1038/39724  0.369
1997 Perez-Terzic C, Jaconi M, Clapham DE. Nuclear calcium and the regulation of the nuclear pore complex. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 19: 787-92. PMID 9297969 DOI: 10.1002/bies.950190908  0.315
1997 Jaconi M, Pyle J, Bortolon R, Ou J, Clapham D. Calcium release and influx colocalize to the endoplasmic reticulum. Current Biology : Cb. 7: 599-602. PMID 9259550 DOI: 10.1016/S0960-9822(06)00259-4  0.386
1997 Ackerman MJ, Clapham DE. Ion channels--basic science and clinical disease. The New England Journal of Medicine. 336: 1575-86. PMID 9164815 DOI: 10.1056/NEJM199705293362207  0.442
1997 Wickman K, Seldin MF, James MR, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Icln gene. Genomics. 40: 402-8. PMID 9073507 DOI: 10.1006/geno.1996.4600  0.609
1997 Wickman K, Seldin MF, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Girk4 gene. Genomics. 40: 395-401. PMID 9073506 DOI: 10.1006/Geno.1997.4599  0.629
1996 Kennedy ME, Nemec J, Clapham DE. Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. Neuropharmacology. 35: 831-9. PMID 8938714 DOI: 10.1016/0028-3908(96)00132-3  0.423
1996 Clapham DE. Intracellular signalling: more jobs for G beta gamma. Current Biology : Cb. 6: 814-6. PMID 8835861 DOI: 10.1016/S0960-9822(02)00602-4  0.351
1996 Stehno-Bittel L, Perez-Terzic C, Luckhoff A, Clapham DE. Nuclear ion channels and regulation of the nuclear pore. Society of General Physiologists Series. 51: 195-207. PMID 8809944  0.32
1996 Perez-Terzic C, Pyle J, Jaconi M, Stehno-Bittel L, Clapham DE. Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. Science (New York, N.Y.). 273: 1875-7. PMID 8791595 DOI: 10.1126/Science.273.5283.1875  0.324
1996 Hedin KE, Lim NF, Clapham DE. Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes. Neuron. 16: 423-9. PMID 8789957 DOI: 10.1016/S0896-6273(00)80060-4  0.463
1996 Aleksandrov A, Velimirovic B, Clapham DE. Inward rectification of the IRK1 K+ channel reconstituted in lipid bilayers. Biophysical Journal. 70: 2680-7. PMID 8744305 DOI: 10.1016/S0006-3495(96)79837-5  0.486
1996 Navarro B, Kennedy ME, Velimirovíc B, Bhat D, Peterson AS, Clapham DE. Nonselective and G betagamma-insensitive weaver K+ channels. Science (New York, N.Y.). 272: 1950-3. PMID 8658170 DOI: 10.1126/science.272.5270.1950  0.45
1996 Velimirovic BM, Gordon EA, Lim NF, Navarro B, Clapham DE. The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel. Febs Letters. 379: 31-7. PMID 8566224 DOI: 10.1016/0014-5793(95)01465-9  0.477
1995 Krapivinsky G, Gordon EA, Wickman K, Velimirović B, Krapivinsky L, Clapham DE. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 374: 135-41. PMID 7877685 DOI: 10.1038/374135A0  0.677
1995 Wickman KD, Clapham DE. G-protein regulation of ion channels. Current Opinion in Neurobiology. 5: 278-85. PMID 7580149 DOI: 10.1016/0959-4388(95)80039-5  0.714
1995 Stehno-Bittel L, Lückhoff A, Clapham DE. Calcium release from the nucleus by InsP3 receptor channels. Neuron. 14: 163-7. PMID 7530018 DOI: 10.1016/0896-6273(95)90250-3  0.436
1995 Krapivinsky G, Krapivinsky L, Velimirovic B, Wickman K, Navarro B, Clapham DE. The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. The Journal of Biological Chemistry. 270: 28777-9. PMID 7499400 DOI: 10.1074/Jbc.270.48.28777  0.659
1995 Krapivinsky G, Krapivinsky L, Wickman K, Clapham DE. G beta gamma binds directly to the G protein-gated K+ channel, IKACh. The Journal of Biological Chemistry. 270: 29059-62. PMID 7493925 DOI: 10.1074/Jbc.270.49.29059  0.607
1995 Wickman K, Clapham DE. Ion channel regulation by G proteins. Physiological Reviews. 75: 865-85. PMID 7480165 DOI: 10.1152/Physrev.1995.75.4.865  0.71
1994 Krapivinsky GB, Ackerman MJ, Gordon EA, Krapivinsky LD, Clapham DE. Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln. Cell. 76: 439-48. PMID 8313467 DOI: 10.1016/0092-8674(94)90109-0  0.392
1994 Clapham DE. Direct G protein activation of ion channels? Annual Review of Neuroscience. 17: 441-64. PMID 8210183 DOI: 10.1146/annurev.ne.17.030194.002301  0.46
1994 Ackerman MJ, Wickman KD, Clapham DE. Hypotonicity activates a native chloride current in Xenopus oocytes. The Journal of General Physiology. 103: 153-79. PMID 8189203 DOI: 10.1085/Jgp.103.2.153  0.697
1994 Wickman KD, Iñiguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE. Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature. 368: 255-7. PMID 8145826 DOI: 10.1038/368255A0  0.596
1994 Lückhoff A, Clapham DE. Calcium channels activated by depletion of internal calcium stores in A431 cells. Biophysical Journal. 67: 177-82. PMID 7918985 DOI: 10.1016/S0006-3495(94)80467-9  0.476
1993 Ackerman MJ, Clapham DE. Cardiac chloride channels. Trends in Cardiovascular Medicine. 3: 23-8. PMID 21244967 DOI: 10.1016/1050-1738(93)90024-Z  0.466
1993 Clapham DE, Neer EJ. New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature. 365: 403-6. PMID 8413584 DOI: 10.1038/365403a0  0.385
1993 Girard S, Clapham D. Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx Science. 260: 229-232. PMID 8385801 DOI: 10.1126/Science.8385801  0.322
1993 Atri A, Amundson J, Clapham D, Sneyd J. A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte Biophysical Journal. 65: 1727-1739. PMID 8274661 DOI: 10.1016/S0006-3495(93)81191-3  0.343
1993 Clapham DE. Mutations in G protein-linked receptors: novel insights on disease. Cell. 75: 1237-9. PMID 8269505 DOI: 10.1016/0092-8674(93)90609-T  0.344
1992 Neer EJ, Clapham DE. Signal transduction through G proteins in the cardiac myocyte. Trends in Cardiovascular Medicine. 2: 6-11. PMID 21239281 DOI: 10.1016/1050-1738(92)90037-S  0.392
1992 Lechleiter JD, Clapham DE. Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes. Cell. 69: 283-94. PMID 1568248 DOI: 10.1016/0092-8674(92)90409-6  0.309
1992 Lechleiter JD, Clapham DE. Spiral waves and intracellular calcium signalling. Journal of Physiology, Paris. 86: 123-8. PMID 1343590 DOI: 10.1016/S0928-4257(05)80016-6  0.304
1992 Paulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D. New mammalian chloride channel identified by expression cloning. Nature. 356: 238-41. PMID 1313151 DOI: 10.1038/356238A0  0.694
1992 Lückhoff A, Clapham DE. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca(2+)-permeable channel. Nature. 355: 356-8. PMID 1309941 DOI: 10.1038/355356a0  0.414
1991 Lechleiter J, Girard S, Clapham D, Peralta E. Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors Nature. 350: 505-508. PMID 1849616 DOI: 10.1038/350505A0  0.315
1991 Wallert MA, Ackerman MJ, Kim D, Clapham DE. Two novel cardiac atrial K+ channels, IK.AA and IK.PC. The Journal of General Physiology. 98: 921-39. PMID 1765763 DOI: 10.1085/Jgp.98.5.921  0.482
1991 Tabares L, Mazzanti M, Clapham DE. Chloride channels in the nuclear membrane. The Journal of Membrane Biology. 123: 49-54. PMID 1723103 DOI: 10.1007/BF01993962  0.668
1991 Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE. Cloning and expression of a rat cardiac delayed rectifier potassium channel. Proceedings of the National Academy of Sciences of the United States of America. 88: 7892-5. PMID 1715584 DOI: 10.1073/Pnas.88.17.7892  0.336
1990 Nanavati C, Clapham DE, Ito H, Kurachi Y. A comparison of the roles of purified G protein subunits in the activation of the cardiac muscarinic K+ channel. Society of General Physiologists Series. 45: 29-41. PMID 2116040  0.317
1990 Clapham DE. Arachidonic acid and its metabolites in the regulation of G-protein gated K+ channels in atrial myocytes. Biochemical Pharmacology. 39: 813-5. PMID 2106888 DOI: 10.1016/0006-2952(90)90194-P  0.425
1990 Lewis DL, Lechleiter JD, Kim D, Nanavati C, Clapham DE. Intracellular regulation of ion channels in cell membranes. Mayo Clinic Proceedings. 65: 1127-43. PMID 1697015 DOI: 10.1016/S0025-6196(12)62726-8  0.479
1990 Lechleiter JD, Hellmiss R, Duerson K, Ennulat D, David N, Clapham D, Peralta E. Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. The Embo Journal. 9: 4381-4390. DOI: 10.1002/J.1460-2075.1990.Tb07888.X  0.308
1989 Kim D, Clapham DE. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. Science (New York, N.Y.). 244: 1174-6. PMID 2727703 DOI: 10.1126/Science.2727703  0.468
1989 Clapham DE, Kim D. G protein activation mechanisms of the cardiac K+ channel, iK.ACh. Society of General Physiologists Series. 44: 55-68. PMID 2675324  0.305
1989 Lewis DL, Clapham DE. Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells. Pflã¼Gers Archiv : European Journal of Physiology. 414: 492-4. PMID 2571974 DOI: 10.1007/BF00585062  0.458
1989 Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, Clapham DE. G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. Nature. 337: 557-60. PMID 2492640 DOI: 10.1038/337557A0  0.399
1988 Neer EJ, Clapham DE. Roles of G protein subunits in transmembrane signalling. Nature. 333: 129-34. PMID 3130578 DOI: 10.1038/333129a0  0.389
1988 Clapham DE, Logothetis DE. Delayed rectifier K+ current in embryonic chick heart ventricle. The American Journal of Physiology. 254: H192-7. PMID 2827524 DOI: 10.1152/Ajpheart.1988.254.1.H192  0.653
1988 Logothetis DE, Kim DH, Northup JK, Neer EJ, Clapham DE. Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 85: 5814-8. PMID 2457901 DOI: 10.1073/Pnas.85.16.5814  0.582
1988 Olesen SP, Davies PF, Clapham DE. Muscarinic-activated K+ current in bovine aortic endothelial cells. Circulation Research. 62: 1059-64. PMID 2454760 DOI: 10.1161/01.Res.62.6.1059  0.345
1988 Clapham D, Neer E. Activation of atrial muscarinic-gated K+ channels by beta gamma-subunits of G proteins. The American Journal of Physiology. 254: H1224. PMID 2454588 DOI: 10.1152/AJPHEART.1988.254.6.H1224  0.413
1988 Fish RD, Sperti G, Colucci WS, Clapham DE. Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. Circulation Research. 62: 1049-54. PMID 2452033 DOI: 10.1161/01.RES.62.5.1049  0.361
1987 Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature. 325: 321-6. PMID 2433589 DOI: 10.1038/325321A0  0.647
1987 Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. G protein opening of K+ channels Nature. 327: 22. DOI: 10.1038/327022A0  0.63
1987 Kurachi Y, Nakajima T, Sugimoto T, Clapham DE, Logothetis DE, Neer EJ, Galper J. On the molecular regulation of muscarinic K+ channel by GTP-binding proteins in cardiac atrial myocytes Biomedical Research. 8: 135-142.  0.571
1985 Bormann J, Clapham DE. gamma-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study. Proceedings of the National Academy of Sciences of the United States of America. 82: 2168-72. PMID 2580307 DOI: 10.1073/Pnas.82.7.2168  0.424
1984 Clapham DE, Defelice LJ. Voltage-activated k channels in embryonic chick heart. Biophysical Journal. 45: 40-2. PMID 19431556 DOI: 10.1016/S0006-3495(84)84099-0  0.67
1984 Ypey DL, Clapham DE. Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages. Proceedings of the National Academy of Sciences of the United States of America. 81: 3083-7. PMID 6328495 DOI: 10.1073/Pnas.81.10.3083  0.379
1984 Clapham DE, Neher E. Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. The Journal of Physiology. 347: 255-77. PMID 6200595 DOI: 10.1113/jphysiol.1984.sp015065  0.559
1984 Clapham DE, Neher E. Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells. The Journal of Physiology. 353: 541-64. PMID 6090644 DOI: 10.1113/jphysiol.1984.sp015350  0.604
1982 Clapham DE, DeFelice LJ. Small signal impedance of heart cell membranes. The Journal of Membrane Biology. 67: 63-71. PMID 7097756 DOI: 10.1007/BF01868648  0.599
1980 Clapham DE, Shrier A, DeHaan RL. Junctional resistance and action potential delay between embryonic heart cell aggregates. The Journal of General Physiology. 75: 633-54. PMID 7391810 DOI: 10.1085/jgp.75.6.633  0.553
1979 Ypey DL, Clapham DE, DeHaan RL. Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells. The Journal of Membrane Biology. 51: 75-96. PMID 522130 DOI: 10.1007/BF01869344  0.558
Low-probability matches (unlikely to be authored by this person)
2003 Wei X, Henke VG, Strübing C, Brown EB, Clapham DE. Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophysical Journal. 84: 1317-27. PMID 12547812 DOI: 10.1016/S0006-3495(03)74947-9  0.3
1991 Lechleiter J, Girard S, Peralta E, Clapham D. Spiral calcium wave propagation and annihilation in Xenapus laevis oocytes Science. 252: 123-126. PMID 2011747 DOI: 10.1126/Science.2011747  0.3
1988 Davies PF, Olesen SP, Clapham DE, Morrel EM, Schoen FJ. Endothelial communication. State of the art lecture. Hypertension. 11: 563-72. PMID 2455686 DOI: 10.1161/01.Hyp.11.6.563.A  0.299
2009 Zhou H, Clapham DE. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 106: 15750-5. PMID 19717468 DOI: 10.1073/pnas.0908332106  0.295
1995 Perez-Terzic CM, Chini EN, Shen SS, Dousa TP, Clapham DE. Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. The Biochemical Journal. 312: 955-9. PMID 8554544 DOI: 10.1042/Bj3120955  0.293
2013 Clapham DE. The mother of all endocytosis. Elife. 2: e01738. PMID 24282238 DOI: 10.7554/eLife.01738  0.293
1997 Perez-Terzic C, Stehno-Bittel L, Clapham DE. Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium indicator Fluo-3. Cell Calcium. 21: 275-82. PMID 9160163 DOI: 10.1016/S0143-4160(97)90115-9  0.289
1992 Girard S, Luckhoff A, Lechleiter JD, Sneyd J, Clapham D. Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes. Biophysical Journal. 61: 509-517. PMID 1547335 DOI: 10.1016/S0006-3495(92)81855-6  0.289
2004 Zhuang ZY, Xu H, Clapham DE, Ji RR. Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8300-9. PMID 15385613 DOI: 10.1523/Jneurosci.2893-04.2004  0.288
1997 Clapham DE, Neer EJ. G protein beta gamma subunits. Annual Review of Pharmacology and Toxicology. 37: 167-203. PMID 9131251 DOI: 10.1146/annurev.pharmtox.37.1.167  0.286
2019 Deo C, Sheu SH, Seo J, Clapham DE, Lavis LD. Isomeric tuning yields bright and targetable red Ca indicators. Journal of the American Chemical Society. PMID 31430138 DOI: 10.1021/Jacs.9B06092  0.283
1995 Stehno-Bittel L, Perez-Terzic C, Clapham DE. Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store. Science (New York, N.Y.). 270: 1835-8. PMID 8525380 DOI: 10.1126/Science.270.5243.1835  0.283
1996 Clapham DE. The G-protein nanomachine. Nature. 379: 297-9. PMID 8552180 DOI: 10.1038/379297a0  0.283
2003 Footitt S, Ingouff M, Clapham D, von Arnold S. Expression of the viviparous 1 (Pavp1) and p34cdc2 protein kinase (cdc2Pa) genes during somatic embryogenesis in Norway spruce (Picea abies [L.] Karst). Journal of Experimental Botany. 54: 1711-9. PMID 12754264 DOI: 10.1093/jxb/erg178  0.283
2013 Chaudhuri D, Artiga D, Clapham DE. Properties of the Mitochondrial Permeability Transition in Drosophila S2R+ Cells Biophysical Journal. 104: 658a. DOI: 10.1016/J.Bpj.2012.11.3633  0.282
2013 Jiang D, Zhao L, Clish CB, Clapham DE. Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proceedings of the National Academy of Sciences of the United States of America. 110: E2249-54. PMID 23716663 DOI: 10.1073/pnas.1308558110  0.281
1993 Duerson K, Carroll R, Clapham D. Alpha-helical distorting substitution disrupt coupling between m3 muscarinic receptor and G proteins. Febs Letters. 324: 103-8. PMID 7684986 DOI: 10.1016/0014-5793(93)81541-7  0.281
1999 Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE. pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Molecular and Cellular Biology. 19: 4113-20. PMID 10330151 DOI: 10.1128/Mcb.19.6.4113  0.28
2000 Sabala I, Elfstrand M, Farbos I, Clapham D, Arnold Sv. Tissue-specific expression of Pa18, a putative lipid transfer protein gene, during embryo development in Norway spruce (Picea abies). Plant Molecular Biology. 42: 461-478. PMID 10798616 DOI: 10.1023/A:1006303702086  0.28
2011 Clapham D. Feeling the heat - Temperature sensing by ion channels - How do they do it? Biochemist. 33: 22-25.  0.278
2001 Lindroth AM, Saarikoski P, Flygh G, Clapham D, Grönroos R, Thelander M, Ronne H, von Arnold S. Two S-adenosylmethionine synthetase-encoding genes differentially expressed during adventitious root development in Pinus contorta. Plant Molecular Biology. 46: 335-46. PMID 11488480 DOI: 10.1023/A:1010637012528  0.276
1995 Stehno-Bittel L, Krapivinsky G, Krapivinsky L, Perez-Terzic C, Clapham DE. The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes. The Journal of Biological Chemistry. 270: 30068-74. PMID 8530411 DOI: 10.1074/JBC.270.50.30068  0.276
2013 Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. Author response: MCU encodes the pore conducting mitochondrial calcium currents Elife. DOI: 10.7554/Elife.00704.006  0.273
1994 Stehno-Bittel L, Amundson J, Clapham D. G-protein-mediated pathways assayed by electrophysiology and confocal microscopy Methods in Enzymology. 238: 321-335. PMID 7799799 DOI: 10.1016/0076-6879(94)38029-5  0.273
2008 Dhuna M, Beezer AE, Connor JA, Clapham D, Courtice C, Frost J, Gaisford S. LED-array photocalorimetry: Instrument design and application to photostability of nifedipine Journal of Pharmaceutical and Biomedical Analysis. 48: 1316-1320. PMID 18929456 DOI: 10.1016/j.jpba.2008.09.007  0.267
2009 CLAPHAM D. Properties of plant nuclease 1 purified from Tradescantia leaves by binding to Concanavalin A-Sepharose Hereditas. 93: 137-146. DOI: 10.1111/J.1601-5223.1980.TB01054.X  0.267
2013 Uddenberg D, Reimegård J, Clapham D, Almqvist C, von Arnold S, Emanuelsson O, Sundström JF. Early cone setting in Picea abies acrocona is associated with increased transcriptional activity of a MADS box transcription factor. Plant Physiology. 161: 813-23. PMID 23221834 DOI: 10.1104/pp.112.207746  0.266
1993 Hedin KE, Duerson K, Clapham DE. Specificity of receptor-G protein interactions: searching for the structure behind the signal. Cellular Signalling. 5: 505-18. PMID 8312128 DOI: 10.1016/0898-6568(93)90046-O  0.265
2012 Quang TH, Hallingbäck H, Gyllenstrand N, Arnold Sv, Clapham D. Expression of genes of cellulose and lignin synthesis in Eucalyptus urophylla and its relation to some economic traits Trees-Structure and Function. 26: 893-901. DOI: 10.1007/S00468-011-0664-5  0.265
1994 Girard S, Clapham DE. Simultaneous near ultraviolet and visible excitation confocal microscopy of calcium transients in Xenopus oocytes. Methods in Cell Biology. 40: 263-84. PMID 8201979 DOI: 10.1016/S0091-679X(08)61118-8  0.265
2006 Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 127: 1137-50. PMID 17123591 DOI: 10.1016/J.Cell.2006.10.028  0.26
1976 Clapham DE, De Felice LJ. The theoretical small signal impedance of the frog node, Rana pipiens. Pflã¼Gers Archiv : European Journal of Physiology. 366: 273-6. PMID 1087004 DOI: 10.1007/Bf00585890  0.259
1996 Saarikoski P, Clapham D, Arnold Sv. A wound-inducible gene from Salix viminalis coding for a trypsin inhibitor. Plant Molecular Biology. 31: 465-478. PMID 8790281 DOI: 10.1007/Bf00042221  0.259
1995 Clapham DE. Intracellular calcium. Replenishing the stores. Nature. 375: 634-5. PMID 7791893 DOI: 10.1038/375634a0  0.257
2002 Ciavatta VT, Egertsdotter U, Clapham D, Arnold Sv, Cairney J. A promoter from the loblolly pine PtNIP1;1 gene directs expression in an early-embryogenesis and suspensor-specific fashion. Planta. 215: 694-698. PMID 12172854 DOI: 10.1007/S00425-002-0822-5  0.255
2005 Goodacre CJ, Bromidge SM, Clapham D, King FD, Lovell PJ, Allen M, Campbell LP, Holland V, Riley GJ, Starr KR, Trail BK, Wood MD. A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 4989-93. PMID 16168649 DOI: 10.1016/j.bmcl.2005.08.004  0.254
2013 Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, ... ... Clapham DE, et al. The Concise Guide to PHARMACOLOGY 2013/14: overview. British Journal of Pharmacology. 170: 1449-58. PMID 24528237 DOI: 10.1111/Bph.12444  0.249
1995 Clapham D, Manders G, Yibrah HS, von Arnold S. Enhancement of short- and medium-term expression of transgenes in embryogenic suspensions ofPicea abies(L.) Karst Journal of Experimental Botany. 46: 655-662. DOI: 10.1093/JXB/46.6.655  0.248
1993 Clapham DE. Cellular calcium. A mysterious new influx factor? Nature. 364: 763-4. PMID 8395023 DOI: 10.1038/364763a0  0.247
2020 von Arnold S, Zhu T, Larsson E, Uddenberg D, Clapham D. Regulation of Somatic Embryo Development in Norway Spruce. Methods in Molecular Biology (Clifton, N.J.). 2122: 241-255. PMID 31975307 DOI: 10.1007/978-1-0716-0342-0_17  0.247
1999 Lindroth AM, Grönroos R, Clapham D, Svensson J, von Arnold S. Ubiquitous and tissue-specific gus expression in transgenic roots conferred by six different promoters in one coniferous and three angiosperm species Plant Cell Reports. 18: 820-828. DOI: 10.1007/s002990050668  0.247
2000 Clapham D, Elfstrand M, Sabala I, Von Arnold S, Demel P, Koop H. Gene Transfer by Particle Bombardment to Embryogenic Cultures of Picea abies and the Production of Transgenic Plantlets Scandinavian Journal of Forest Research. 15: 151-160. DOI: 10.1080/028275800750014957  0.247
2002 Sandler VM, Wang S, Angelo K, Lo HG, Breakefield XO, Clapham DE. Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. Journal of Neuroscience Methods. 121: 211-9. PMID 12468010 DOI: 10.1016/S0165-0270(02)00262-5  0.246
2013 Minina EA, Filonova LH, Fukada K, Savenkov EI, Gogvadze V, Clapham D, Sanchez-Vera V, Suarez MF, Zhivotovsky B, Daniel G, Smertenko A, Bozhkov PV. Autophagy and metacaspase determine the mode of cell death in plants. The Journal of Cell Biology. 203: 917-27. PMID 24344187 DOI: 10.1083/jcb.201307082  0.246
2012 Abrahamsson M, Valladares S, Larsson E, Clapham D, Arnold Sv. Patterning during somatic embryogenesis in Scots pine in relation to polar auxin transport and programmed cell death Plant Cell Tissue and Organ Culture. 109: 391-400. DOI: 10.1007/S11240-011-0103-8  0.246
1997 Clapham DE. In Memoriam: Fredric S. Fay Neuron. 18: 697. DOI: 10.1016/S0896-6273(97)00002-0  0.245
2013 Karlgren A, Gyllenstrand N, Clapham D, Lagercrantz U. FLOWERING LOCUS T/TERMINAL FLOWER1-like genes affect growth rhythm and bud set in Norway spruce. Plant Physiology. 163: 792-803. PMID 23958861 DOI: 10.1104/pp.113.224139  0.244
1993 Sneyd J, Girard S, Clapham D. Calcium wave propagation by calcium-induced calcium release : an unusual excitable system Bulletin of Mathematical Biology. 55: 315-344. DOI: 10.1016/S0092-8240(05)80268-X  0.244
1996 Yibrah HS, Grönroos R, Lindroth A, Franzén H, Clapham D, Arnold Sv. Agrobacterium rhizogenes-mediated induction of adventitious rooting from Pinus contorta hypocotyls and the effect of 5-azacytidine on transgene activity Transgenic Research. 5: 75-85. DOI: 10.1007/Bf01969425  0.242
2004 Legin A, Rudnitskaya A, Clapham D, Seleznev B, Lord K, Vlasov Y. Electronic tongue for pharmaceutical analytics: quantification of tastes and masking effects. Analytical and Bioanalytical Chemistry. 380: 36-45. PMID 15365669 DOI: 10.1007/S00216-004-2738-3  0.239
2008 Wadenbäck J, von Arnold S, Egertsdotter U, Walter MH, Grima-Pettenati J, Goffner D, Gellerstedt G, Gullion T, Clapham D. Lignin biosynthesis in transgenic Norway spruce plants harboring an antisense construct for cinnamoyl CoA reductase (CCR). Transgenic Research. 17: 379-92. PMID 17610137 DOI: 10.1007/S11248-007-9113-Z  0.235
2015 Cocorocchio M, Ives R, Clapham D, Andrews PL, Williams RS. Bitter tastant responses in the amoeba Dictyostelium correlate with rat and human taste assays. Altex. PMID 26708104 DOI: 10.14573/altex.1509011  0.233
2013 Procopiou PA, Barrett JW, Barton NP, Begg M, Clapham D, Copley RC, Ford AJ, Graves RH, Hall DA, Hancock AP, Hill AP, Hobbs H, Hodgson ST, Jumeaux C, Lacroix YM, et al. Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists. Journal of Medicinal Chemistry. 56: 1946-60. PMID 23409871 DOI: 10.1021/jm301572h  0.233
2008 Smyth CJ, Clapham D. Use of immunoprecipitates to obtain monospecific immunoglobulins to nuclease 1 of Tradescantia Hereditas. 96: 69-75. DOI: 10.1111/J.1601-5223.1982.Tb00035.X  0.232
2008 Clapham D. Immunocytochemistry of nuclease 1 of Tradescantia Hereditas. 96: 77-84. DOI: 10.1111/J.1601-5223.1982.Tb00036.X  0.23
2014 Gyllenstrand N, Karlgren A, Clapham D, Holm K, Hall A, Gould PD, Källman T, Lagercrantz U. No time for spruce: rapid dampening of circadian rhythms in Picea abies (L. Karst). Plant & Cell Physiology. 55: 535-50. PMID 24363286 DOI: 10.1093/Pcp/Pct199  0.23
2013 Rudnitskaya A, Kirsanov D, Blinova Y, Legin E, Seleznev B, Clapham D, Ives RS, Saunders KA, Legin A. Assessment of bitter taste of pharmaceuticals with multisensor system employing 3 way PLS regression. Analytica Chimica Acta. 770: 45-52. PMID 23498685 DOI: 10.1016/j.aca.2013.02.006  0.228
1981 Clapham D. Contamination of commercial acid phosphatases with nuclease Protoplasma. 107: 109-113. DOI: 10.1007/Bf01275611  0.227
2010 Febvay S, Marini DM, Belcher AM, Clapham DE. Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. Nano Letters. 10: 2211-9. PMID 20446663 DOI: 10.1021/Nl101157Z  0.223
2017 Walker AL, Ancellin N, Beaufils B, Bergeal M, Binnie M, Clapham D, Haslam CP, Holmes DS, Hutchinson JP, Liddle J, McBride A, Mirguet O, Mowat CG, Rowland P, Tiberghien N, et al. Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. Journal of Medicinal Chemistry. PMID 28398044 DOI: 10.1021/acs.jmedchem.7b00055  0.223
2017 Dobrowolska I, Andrade GM, Clapham D, Egertsdotter U. Histological analysis reveals the formation of shoots rather than embryos in regenerating cultures of Eucalyptus globulus Plant Cell Tissue and Organ Culture. 128: 319-326. DOI: 10.1007/S11240-016-1111-5  0.221
2005 Ji R, Zhuang Z, Xu H, Clapham D. Phosphatidylinositol 3-kinase (PI3K) cascade is a novel signaling pathway to mediate inflammatory pain The Journal of Pain. 6: S11. DOI: 10.1016/J.JPAIN.2005.01.040  0.215
2010 Quang TH, Kien ND, Arnold Sv, Jansson G, Thinh HH, Clapham D. Relationship of wood composition to growth traits of selected open-pollinated families of Eucalyptus urophylla from a progeny trial in Vietnam New Forests. 39: 301-312. DOI: 10.1007/S11056-009-9172-5  0.211
2007 Dhuna M, Beezer AE, Morris AC, Gaisford S, O'Neill MA, Hadgraft J, Connor JA, Clapham D, Frost J. Development of an isothermal heat-conduction photocalorimeter. The Review of Scientific Instruments. 78: 025105. PMID 17578146 DOI: 10.1063/1.2670220  0.211
1994 Clapham DE. Signal transduction. Why testicles are cool. Nature. 371: 109-10. PMID 8072540 DOI: 10.1038/371109a0  0.211
1993 BLITON C, LECHLEITER J, CLAPHAM DE. Optical modifications enabling simultaneous confocal imaging with dyes excited by ultraviolet- and visible-wavelength light Journal of Microscopy. 169: 15-26. DOI: 10.1111/j.1365-2818.1993.tb03274.x  0.21
2000 Brukhin V, Clapham D, Elfstrand M, Arnold Sv. Basta tolerance as a selectable and screening marker for transgenic plants of Norway spruce. Plant Cell Reports. 19: 899-903. PMID 30754927 DOI: 10.1007/S002990000217  0.206
2019 Egertsdotter U, Ahmad I, Clapham D. Automation and Scale Up of Somatic Embryogenesis for Commercial Plant Production, With Emphasis on Conifers. Frontiers in Plant Science. 10: 109. PMID 30833951 DOI: 10.3389/fpls.2019.00109  0.206
2006 Shirgurkar MV, Naik VB, von Arnold S, Nadgauda RS, Clapham D. An efficient protocol for genetic transformation and shoot regeneration of turmeric (Curcuma longa L.) via particle bombardment. Plant Cell Reports. 25: 112-6. PMID 16397786 DOI: 10.1007/s00299-005-0033-1  0.203
2018 Dahrendorf J, Clapham D, Egertsdotter U. Analysis of Nitrogen Utilization Capability during the Proliferation and Maturation Phases of Norway Spruce (Picea abies (L.) H.Karst.) Somatic Embryogenesis Forests. 9: 288. DOI: 10.3390/F9060288  0.203
2010 Bowles A, Keane J, Ernest T, Clapham D, Tuleu C. Specific aspects of gastro-intestinal transit in children for drug delivery design. International Journal of Pharmaceutics. 395: 37-43. PMID 20478372 DOI: 10.1016/j.ijpharm.2010.04.048  0.201
1990 Clapham D, Ekberg I, Eriksson G, Hood EE, Norell L. Within-population variation in susceptibility to Agrobacterium tumefaciens A281 in Picea abies (L.) Karst. Theoretical and Applied Genetics. 79: 654-656. PMID 24226580 DOI: 10.1007/Bf00226879  0.2
2007 Clapham DE. Calcium signaling. Cell. 131: 1047-58. PMID 18083096 DOI: 10.1016/j.cell.2007.11.028  0.2
1996 Clapham DE. TRP is cracked but is CRAC TRP? Neuron. 16: 1069-72. PMID 8663982 DOI: 10.1016/S0896-6273(00)80132-4  0.2
2004 Vora KL, Buckton G, Clapham D. The use of dynamic vapour sorption and near infra-red spectroscopy (DVS-NIR) to study the crystal transitions of theophylline and the report of a new solid-state transition. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 22: 97-105. PMID 15158895 DOI: 10.1016/j.ejps.2004.01.009  0.198
1996 Arnold Sv, Clapham D, Egertsdotter U, Mo LH. Somatic embryogenesis in conifers—A case study of induction and development of somatic embryos in Picea abies Plant Growth Regulation. 20: 3-9. DOI: 10.1007/Bf00024050  0.198
2012 Almeida e Sousa L, Beezer AE, Hansen LD, Clapham D, Connor JA, Gaisford S. Calorimetric determination of rate constants and enthalpy changes for zero-order reactions. The Journal of Physical Chemistry. B. 116: 6356-60. PMID 22607190 DOI: 10.1021/Jp302933F  0.198
2019 O'Brien F, Clapham D, Krysiak K, Batchelor H, Field P, Caivano G, Pertile M, Nunn A, Tuleu C. Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine. International Journal of Molecular Sciences. 20. PMID 31159216 DOI: 10.3390/ijms20112688  0.197
1994 Magnussen D, Clapham D, Grönroos R, Arnold Sv. Induction of hairy and normal roots on Picea abies, Pinus sylvestris and Pinus contorta by Agrobacterium rhizogenes Scandinavian Journal of Forest Research. 9: 46-51. DOI: 10.1080/02827589409382811  0.196
2012 Clapham D, Kirsanov D, Legin A, Rudnitskaya A, Saunders K. Corrigendum to: “Assessing taste without using humans: Rat brief access aversion model and electronic tongue” [Int. J. Pharm. 435 (2012) 137–139] International Journal of Pharmaceutics. 439: 359. DOI: 10.1016/J.Ijpharm.2012.09.029  0.196
2013 Baertschi SW, Clapham D, Foti C, Jansen PJ, Kristensen S, Reed RA, Templeton AC, Tønnesen HH. Implications of in-use photostability: proposed guidance for photostability testing and labeling to support the administration of photosensitive pharmaceutical products, part 1: drug products administered by injection. Journal of Pharmaceutical Sciences. 102: 3888-99. PMID 24009146 DOI: 10.1002/jps.23717  0.196
2012 Clapham D, Kirsanov D, Legin A, Rudnitskaya A, Saunders K. Assessing taste without using humans: rat brief access aversion model and electronic tongue. International Journal of Pharmaceutics. 435: 137-9. PMID 22883698 DOI: 10.1016/j.ijpharm.2012.05.056  0.194
2009 Kien ND, Quang TH, Jansson G, Harwood C, Clapham D, Arnold Sv. Cellulose content as a selection trait in breeding for kraft pulp yield in Eucalyptus urophylla Annals of Forest Science. 66: 711-711. DOI: 10.1051/Forest/2009064  0.192
2010 Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, ... ... Clapham DE, et al. Climate change and the integrity of science. Science (New York, N.Y.). 328: 689-90. PMID 20448167 DOI: 10.1126/Science.328.5979.689  0.191
2003 Clapham DE. Symmetry, selectivity, and the 2003 Nobel Prize. Cell. 115: 641-6. PMID 14675526 DOI: 10.1016/S0092-8674(03)00980-2  0.191
2015 Baertschi SW, Clapham D, Foti C, Kleinman MH, Kristensen S, Reed RA, Templeton AC, Tønnesen HH. Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 2: Topical Drug Product. Journal of Pharmaceutical Sciences. PMID 25711373 DOI: 10.1002/jps.24396  0.191
2016 Lopez FL, Bowles A, Gul MO, Clapham D, Ernest TB, Tuleu C. Effect of formulation variables on oral grittiness and preferences of multiparticulate formulations in adult volunteers. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 27402099 DOI: 10.1016/j.ejps.2016.07.006  0.19
2018 Clapham DE. Influences: Short circuits. The Journal of General Physiology. PMID 29559507 DOI: 10.1085/jgp.201812034  0.187
1996 Clapham D, Nicholson R, Taskis C. Some novel methods of dessicating the content of pharmaceutical injection vials European Journal of Pharmaceutical Sciences. 4. DOI: 10.1016/S0928-0987(97)86551-7  0.187
1993 Ghanbari RA, Clapham DE. Fantastic voyagers? Review of B. C. Crandall and James Lewis, Nanotechnology: Research and Perspectives Biophysical Journal. 65: 976-977. DOI: 10.1016/S0006-3495(93)81132-9  0.186
1996 Clapham D, Rogers P. Evaluation of electronic sensory detection technology for pharmaceutical samples European Journal of Pharmaceutical Sciences. 4. DOI: 10.1016/S0928-0987(97)86492-5  0.184
1996 Campbell K, Clapham D, Thomas K. Use of qunatitative colour measurement as a tool to measure crystallisation processes during formulation development European Journal of Pharmaceutical Sciences. 4: S163. DOI: 10.1016/S0928-0987(97)86490-1  0.183
2004 Wadenback J, Clapham D, Gellerstedt G, Arnold Sv. Variation in content and composition of lignin in young wood of Norway spruce Holzforschung. 58: 107-115. DOI: 10.1515/Hf.2004.015  0.179
2018 Cocorocchio M, Ives R, Clapham D, Andrews PL, Williams RS. Introducing a new model for bitter taste assessment – The social amoeba dictyostelium International Journal of Pharmaceutics. 536: 491. DOI: 10.1016/j.ijpharm.2017.08.012  0.179
1988 Olesen SP, Clapham DE, Davies PF. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature. 331: 168-70. PMID 2448637 DOI: 10.1038/331168A0  0.173
1988 Olesen SP, Clapham DE, Davies PF. Heamodynamic shear stress activates a K+ current in vascular endothelial cells Gynecologic Oncology. 29: 168-170.  0.172
2011 Squillace RM, Miller D, Cookson M, Wardwell SD, Moran L, Clapham D, Wang F, Clackson T, Rivera VM. Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models. Molecular Cancer Therapeutics. 10: 1959-68. PMID 21825008 DOI: 10.1158/1535-7163.MCT-11-0273  0.141
1995 Hedin KE, Appleby MW, Clapham DE. Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes. Immunology. 84: 183-92. PMID 7750993  0.129
2009 Clapham D. Sparklebunnies are go! Perspectives in Public Health. 129: 160-1. PMID 19650548 DOI: 10.1177/1757913908105950  0.12
2007 Gyllenstrand N, Clapham D, Källman T, Lagercrantz U. A Norway spruce FLOWERING LOCUS T homolog is implicated in control of growth rhythm in conifers. Plant Physiology. 144: 248-57. PMID 17369429 DOI: 10.1104/pp.107.095802  0.104
1995 Clapham DE. Calcium signaling. Cell. 80: 259-68. PMID 7834745 DOI: 10.1016/0092-8674(95)90408-5  0.092
2008 von Arnold S, Clapham D. Spruce embryogenesis. Methods in Molecular Biology (Clifton, N.J.). 427: 31-47. PMID 18369995 DOI: 10.1007/978-1-59745-273-1_3  0.087
1991 Clapham D. Cell Signalling.Noel G. Morgan The Quarterly Review of Biology. 66: 74-74. DOI: 10.1086/417061  0.084
1995 Clapham DE, Sneyd J. Intracellular calcium waves. Advances in Second Messenger and Phosphoprotein Research. 30: 1-24. PMID 7695987  0.077
2023 Clapham D, Belissa E, Inghelbrecht S, Pensé-Lhéritier AM, Ruiz F, Sheehan L, Shine M, Vallet T, Walsh J, Tuleu C. A Guide to Best Practice in Sensory Analysis of Pharmaceutical Formulations. Pharmaceutics. 15. PMID 37765288 DOI: 10.3390/pharmaceutics15092319  0.076
2021 Salunke S, Clapham D, Agrawal A, Hughes K, Nunn T. Best Practices for Selection of Excipients for Paediatrics - Workshop Reflection. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 33400989 DOI: 10.1016/j.ejpb.2020.12.021  0.066
1993 Clapham DE, Lechleiter JD, Girard S. Intracellular waves observed by confocal microscopy from Xenopus oocytes. Advances in Second Messenger and Phosphoprotein Research. 28: 161-5. PMID 8398398  0.065
2021 Clapham D, Bennett J, Cram A, Discihnger A, Inghelbrecht S, Pense-Lheriter AM, Ruiz F, Salunke S, Schiele J, Soto J, Walsh J, Tuleu C. Proposed Tool to Compare and Assess the Applicability of Taste Assessment Techniques for Pharmaceuticals. Journal of Pharmaceutical Sciences. PMID 34499899 DOI: 10.1016/j.xphs.2021.09.002  0.063
2020 Tuleu C, Hughes DA, Clapham D, Vallet T, Ruiz F. Acceptability of generic versus innovator oral medicines: not only a matter of taste. Drug Discovery Today. PMID 33217597 DOI: 10.1016/j.drudis.2020.11.008  0.061
2022 Bulumulla C, Krasley AT, Cristofori-Armstrong B, Valinsky WC, Walpita D, Ackerman D, Clapham DE, Beyene AG. Visualizing synaptic dopamine efflux with a 2D composite nanofilm. Elife. 11. PMID 35786443 DOI: 10.7554/eLife.78773  0.058
2004 Ackerman MJ, Clapham DE. Excitability and Conduction Molecular Basis of Cardiovascular Disease: a Companion to Braunwald's Heart Disease. 311-335. DOI: 10.1016/B978-0-7216-9428-3.50023-8  0.056
2023 Ruiz F, Nunn A, Gill A, Clapham D, Fotaki N, Salunke S, Cram A, O'Brien F. A review of paediatric injectable drug delivery to inform the study of product acceptability - an introduction. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 37100092 DOI: 10.1016/j.ejpb.2023.04.010  0.049
2016 Allain L, Baertschi SW, Clapham D, Foti C, Lantaff WM, Reed RA, Templeton AC, Tønnesen HH. Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products Part 3. Oral Drug Products. Journal of Pharmaceutical Sciences. PMID 27056630 DOI: 10.1016/j.xphs.2016.02.035  0.031
2019 Clapham DE. Primary cilia and other mysteries Proceedings For Annual Meeting of the Japanese Pharmacological Society. 92: 3-SL10. DOI: 10.1254/JPSSUPPL.92.0_3-SL10  0.019
2014 Penezina O, Krueger NX, Rodriguez-Chavez IR, Busch MP, Hural J, Kim JH, O'Connell RJ, Hunter E, Aboud S, Higgins K, Kovalenko V, Clapham D, Crane D, Levin AE. Performance of a redesigned HIV Selectest enzyme-linked immunosorbent assay optimized to minimize vaccine-induced seropositivity in HIV vaccine trial participants. Clinical and Vaccine Immunology : Cvi. 21: 391-8. PMID 24403525 DOI: 10.1128/Cvi.00748-13  0.014
2010 Clapham D. If you have health you have hope, if you have hope you have everything. Perspectives in Public Health. 130: 207-8. PMID 21086813 DOI: 10.1177/1757913910379186  0.01
1993 Clapham DE. Reply. Trends in Cardiovascular Medicine. 3: 114. PMID 21244935 DOI: 10.1016/1050-1738(93)90009-U  0.01
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