Hong C. Shen, Ph.D. - Publications

Affiliations: 
Med. Chem. Roche, Indianapolis, IN, United States 
Area:
Drug discovery

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Year Citation  Score
2018 Zheng X, Liang C, Wang L, Wang B, Liu Y, Feng S, Wu JZ, Gao L, Feng L, Chen L, Guo T, Shen HC, Yun H. Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors. Journal of Medicinal Chemistry. PMID 30339388 DOI: 10.1021/acs.jmedchem.8b01394  0.44
2018 Han X, Zhou C, Jiang M, Wang Y, Wang J, Cheng Z, Wang M, Liu Y, Liang C, Wang J, Wang Z, Weikert R, Lv W, Xie J, Yu X, ... ... Shen HC, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. Journal of Medicinal Chemistry. PMID 30286292 DOI: 10.1021/acs.jmedchem.8b01245  0.92
2018 Wu J, Zhang H, Ding X, Tan X, Chen J, He W, Deng H, Song L, Shen HC, Cao W. Potassium iodide promoted one-pot synthesis of fluoroalkylated quinoxalines via a tandem Michael addition / azidation / cycloamination approach. The Journal of Organic Chemistry. PMID 30025451 DOI: 10.1021/acs.joc.8b01030  0.36
2018 Zhou M, Tan X, Hu Y, Shen HC, Qian X. Highly Chemo- and Regioselective Vinylation of N-Heteroarenes with Vinylsulfonium Salts. The Journal of Organic Chemistry. PMID 29799743 DOI: 10.1021/acs.joc.8b00682  0.44
2018 Feng S, Gao L, Han X, Hu T, Hu Y, Liu H, Thomas AW, Yan Z, Yang S, Young JAT, Yun H, Zhu W, Shen HC. Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection. Acs Infectious Diseases. PMID 29369612 DOI: 10.1021/acsinfecdis.7b00144  0.44
2017 Lu C, Lu H, Wu J, Shen HC, Hu T, Gu Y, Shen Q. Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules. The Journal of Organic Chemistry. PMID 29271195 DOI: 10.1021/acs.joc.7b02989  0.32
2017 Feng S, Li C, Chen D, Zheng X, Yun H, Gao L, Shen HC. Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors. European Journal of Medicinal Chemistry. 138: 1147-1157. PMID 28772235 DOI: 10.1016/j.ejmech.2017.07.032  0.32
2017 Qiu Z, Lin X, Zhang W, Zhou M, Guo L, Kocer B, Wu G, Zhang Z, Liu H, Shi H, Kou B, Hu T, Hu Y, Huang M, Yan SF, ... ... Shen HC, et al. Discovery and Pre-Clinical Characterization of a 3(rd) Generation 4-H HeteroAryldihydroPyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors. Journal of Medicinal Chemistry. PMID 28339215 DOI: 10.1021/acs.jmedchem.7b00083  0.44
2017 Zhou Z, Hu T, Zhou X, Wildum S, Garcia-Alcalde F, Xu Z, Wu D, Mao Y, Tian X, Zhou Y, Shen F, Zhang Z, Tang G, Najera I, Yang G, ... Shen HC, et al. Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Scientific Reports. 7: 42374. PMID 28205569 DOI: 10.1038/srep42374  0.44
2016 Qiu Z, Kuhn B, Aebi J, Lin X, Ding H, Zhou Z, Xu Z, Xu D, Han L, Liu C, Qiu H, Zhang Y, Haap W, Riemer C, Stahl M, ... ... Shen HC, et al. Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors. Acs Medicinal Chemistry Letters. 7: 802-6. PMID 27563406 DOI: 10.1021/acsmedchemlett.6b00208  0.44
2016 Qiu Z, Lin X, Zhou M, Liu Y, Zhu W, Chen W, Zhang W, Guo L, Liu H, Wu G, Huang M, Jiang M, Xu Z, Zhou ZJ, Qin N, ... ... Shen HC, et al. Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors. Journal of Medicinal Chemistry. PMID 27458651 DOI: 10.1021/acs.jmedchem.6b00879  0.44
2016 Zheng X, Wang L, Wang B, Miao K, Xiang K, Feng S, Gao L, Shen HC, Yun H. Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors. Acs Medicinal Chemistry Letters. 7: 558-62. PMID 27326326 DOI: 10.1021/acsmedchemlett.5b00234  0.32
2016 Wang M, Hu Y, Jiang Z, Shen HC, Sun X. Divergent copper-mediated dimerization and hydroxylation of benzamides involving C-H bond functionalization. Organic & Biomolecular Chemistry. PMID 27073988 DOI: 10.1039/c6ob00392c  0.44
2016 Chang JJ, Li YH, Lin GM, Wu CC, Shen HC, Pan RY. Comparison of the recurrence risk of parameniscal cysts between patients treated with arthroscopic excision and arthroscopic decompression techniques. Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the Esska. PMID 26860100 DOI: 10.1007/s00167-016-3998-0  0.52
2016 Hung CC, Wang CC, Lin LC, Pan RY, Shen HC, Lee CH, Huang GS. Profunda femoris artery injury following internal fixation with cannulated hip screws for a femoral neck fracture Journal of Medical Sciences (Taiwan). 36: 31-34. DOI: 10.4103/1011-4564.177176  0.52
2016 Wu G, Kou B, Tang G, Zhu W, Shen HC, Liu H, Hu T. Synthesis of novel and conformationally constrained bridged amino acids as compact modules for drug discovery Tetrahedron Letters. 57: 599-602. DOI: 10.1016/j.tetlet.2015.12.097  0.44
2015 Wang SH, Yang JJ, Shen HC, Lin LC, Lee MS, Pan RY. Using a modified Pauwels method to predict the outcome of femoral neck fracture in relatively young patients. Injury. PMID 26113033 DOI: 10.1016/j.injury.2015.06.016  0.52
2015 Yang C, Balsells J, Chu HD, Cox JM, Crespo A, Ma X, Contino L, Brown P, Gao S, Zamlynny B, Wiltsie J, Clemas J, Lisnock J, Gibson J, Zhou G, ... ... Shen HC, et al. Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists. Acs Medicinal Chemistry Letters. 6: 461-5. PMID 25941555 DOI: 10.1021/acsmedchemlett.5b00010  1
2015 Feng S, Hong D, Wang B, Zheng X, Miao K, Wang L, Yun H, Gao L, Zhao S, Shen HC. Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors. Acs Medicinal Chemistry Letters. 6: 359-62. PMID 25941547 DOI: 10.1021/acsmedchemlett.5b00008  0.32
2015 Chou CH, Lee MT, Song IW, Lu LS, Shen HC, Lee CH, Wu JY, Chen YT, Kraus VB, Wu CC. Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 23: 571-80. PMID 25575966 DOI: 10.1016/j.joca.2014.12.020  0.52
2015 Shen HC, Hu CJ, Li CY, Ko MC, Chen CC. Factors associated with emergency medical care utilization among children in Taiwan Taiwan Journal of Public Health. 34: 50-60. DOI: 10.6288/TJPH201534103108  0.56
2015 Wang SJ, Wang CC, Lee CH, Li YT, Shih JT, Lin LC, Shen HC. Prophylactic fixation of an incomplete subtrochanteric femur fracture due to a low-velocity gunshot injury: A unique case Journal of Medical Sciences (Taiwan). 35: 258-260. DOI: 10.4103/1011-4564.173010  0.52
2015 Shen HC, Liu C, Wang JN, Zheng L, Tian YS, Wan ZL. Study on anti-drilling performance of rock under simulated formation conditions Xi'An Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of Xi'An Shiyou University, Natural Sciences Edition. 30: 22-25 and 32.  0.44
2014 Zhang Z, Lin Z, Zhou Z, Shen HC, Yan SF, Mayweg AV, Xu Z, Qin N, Wong JC, Zhang Z, Rong Y, Fry DC, Hu T. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction. Acs Medicinal Chemistry Letters. 5: 993-8. PMID 25221655 DOI: 10.1021/ml500160m  1
2014 Lee CH, Wu CC, Pan RY, Lu HT, Shen HC. Medial retinacular flap advancement and arthroscopic lateral release for symptomatic chronic patellar lateral subluxation with tilting. Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the Esska. 22: 2499-504. PMID 25082463 DOI: 10.1007/s00167-014-3201-4  0.4
2014 Cox JM, Chu HD, Yang C, Shen HC, Wu Z, Balsells J, Crespo A, Brown P, Zamlynny B, Wiltsie J, Clemas J, Gibson J, Contino L, Lisnock J, Zhou G, et al. Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series. Bioorganic & Medicinal Chemistry Letters. 24: 1681-4. PMID 24630411 DOI: 10.1016/j.bmcl.2014.02.057  1
2014 Shen HC, Tian K, Hu YH. Study on the creep properties of resin concrete Applied Mechanics and Materials. 472: 649-653. DOI: 10.4028/www.scientific.net/AMM.472.649  0.48
2014 Shen Hc, Shi Yf, Feng Bh, Wang Hm, Xu X, Huang Qn, Lü Xg, Wu Jl. Identification and genetic analysis of a novel rice spotted-leaf mutant with broad-spectrum resistance to xanthomonas oryzae pv. oryzae Journal of Integrative Agriculture. 13: 713-721. DOI: 10.1016/S2095-3119(13)60393-7  0.48
2014 Chang FS, Wu JS, Lee CN, Shen HC. Greedy-search-based multi-objective genetic algorithm for emergency logistics scheduling Expert Systems With Applications. 41: 2947-2956. DOI: 10.1016/j.eswa.2013.10.026  0.48
2014 Shu C, Li L, Chen CB, Shen HC, Ye LW. Gold-catalyzed 6-exo-dig cycloisomerization: A versatile approach to functionalized phenanthrenes Chemistry - An Asian Journal. 9: 1525-1529. DOI: 10.1002/asia.201400034  1
2014 Batsanov AS, Georgiou I, Girling PR, Pommier L, Shen HC, Whiting A. Asymmetric synthesis and application of homologous pyrroline-2-alkylboronic acids: Identification of the B-N distance for eliciting bifunctional catalysis of an asymmetric aldol reaction. Asian Journal of Organic Chemistry. 3: 470-479. DOI: 10.1002/ajoc.201300127  1
2013 Shen HC, Graham TH. Gold-catalyzed formation of heterocycles - an enabling new technology for medicinal chemistry. Drug Discovery Today. Technologies. 10: e3-14. PMID 24050224 DOI: 10.1016/j.ddtec.2012.10.014  1
2013 Vandavasi JK, Kuo KK, Hu WP, Shen HC, Lo WS, Wang JJ. A convenient method to construct (Z)-oxazines via 6-exo-dig iodocyclization and synthesis of indolin-3-one. Organic & Biomolecular Chemistry. 11: 6520-5. PMID 23963094 DOI: 10.1039/c3ob41272e  0.4
2013 Yang C, Shen HC, Wu Z, Chu HD, Cox JM, Balsells J, Crespo A, Brown P, Zamlynny B, Wiltsie J, Clemas J, Gibson J, Contino L, Lisnock J, Zhou G, et al. Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 23: 4388-92. PMID 23777778 DOI: 10.1016/j.bmcl.2013.05.077  1
2013 Wu CC, Hsu YC, Chiu YC, Chang YC, Lee CH, Shen HC, Huang GS. Parameniscal cyst formation in the knee is associated with meniscal tear size: an MRI study. The Knee. 20: 556-61. PMID 23587634 DOI: 10.1016/j.knee.2013.03.008  0.52
2013 Cheng CC, Li CY, Hu YJ, Shen HC, Huang SM. Effects of tooth scaling reminders for dental outpatients. Journal of Telemedicine and Telecare. 19: 184-9. PMID 23512651 DOI: 10.1177/1357633X13479700  0.56
2013 Feng BH, Yang Y, Shi YF, Shen HC, Wang HM, Huang QN, Xu X, Lü XG, Wu JL. Characterization and genetic analysis of a novel rice spotted-leaf mutant HM47 with broad-spectrum resistance to Xanthomonas oryzae pv. oryzae. Journal of Integrative Plant Biology. 55: 473-83. PMID 23210861 DOI: 10.1111/jipb.12021  0.52
2013 Hu Y, Zhu W, Tang G, Mayweg AV, Yang G, Wu JZ, Shen HC. Novel therapeutics in discovery and development for treatment of chronic HBV infection Annual Reports in Medicinal Chemistry. 48: 264-281. DOI: 10.1016/B978-0-12-417150-3.00017-X  1
2012 Lin KY, Shen PH, Lee CH, Pan RY, Lin LC, Shen HC. Functional outcomes of surgical reconstruction for posterolateral rotatory instability of the elbow. Injury. 43: 1657-61. PMID 22633695 DOI: 10.1016/j.injury.2012.04.023  0.52
2012 Girling PR, Batsanov AS, Shen HC, Whiting A. A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines. Chemical Communications (Cambridge, England). 48: 4893-5. PMID 22499258 DOI: 10.1039/c2cc31495a  1
2012 Pan RY, Yang JJ, Chang JH, Shen HC, Lin LC, Lian YT. Clinical outcome of arthroscopic fixation of anterior tibial eminence avulsion fractures in skeletally mature patients: a comparison of suture and screw fixation technique. The Journal of Trauma and Acute Care Surgery. 72: E88-93. PMID 22328000 DOI: 10.1097/TA.0b013e3182319d5a  0.52
2012 Shen HC, Ding FX, Jiang J, Verras A, Chabin RM, Xu S, Tong X, Chen Q, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Murphy BA, et al. Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1550-6. PMID 22264488 DOI: 10.1016/j.bmcl.2012.01.002  1
2012 Shen HC, Hammock BD. Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications. Journal of Medicinal Chemistry. 55: 1789-808. PMID 22168898 DOI: 10.1021/jm201468j  1
2012 Graham TH, Shen HC, Liu W, Xiong Y, Verras A, Bleasby K, Bhatt UR, Chabin RM, Chen D, Chen Q, Garcia-Calvo M, Geissler WM, He H, Lassman ME, Shen Z, et al. The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 658-65. PMID 22079761 DOI: 10.1016/j.bmcl.2011.10.060  1
2012 Tsai TY, Yang YS, Tseng FJ, Lin KY, Liu CW, Shen HC, Lee CH, Lin LC, Pan RY. Arthroscopic excision of ganglion cysts of the posterior cruciate ligaments using posterior trans-septal portal. Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 28: 95-9. PMID 22019231 DOI: 10.1016/j.arthro.2011.07.013  0.52
2012 Wu G, Yin W, Shen HC, Huang Y. One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy Green Chemistry. 14: 580-585. DOI: 10.1039/c2gc16457d  1
2011 Lee TS, Shen HC, Wu WH, Huang CW, Yen MY, Wang BE, Chuang P, Shih CY, Chou YC, Liu YL. Clinical characteristics and risk behavior as a function of HIV status among heroin users enrolled in methadone treatment in northern Taiwan. Substance Abuse Treatment, Prevention, and Policy. 6: 6. PMID 21473789 DOI: 10.1186/1747-597X-6-6  0.32
2011 Chang CW, Huang CW, Wu WH, Wang BE, Liu YL, Shen HC, Lee TS. Psychometric properties of the Chinese craving beliefs questionnaire for heroin abusers in methadone treatment. Bmc Psychiatry. 11: 39. PMID 21388523 DOI: 10.1186/1471-244X-11-39  0.32
2011 Shen HC, Ding FX, Zhou C, Xiong Y, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Chen D, et al. Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 1299-305. PMID 21315588 DOI: 10.1016/j.bmcl.2011.01.090  1
2011 Kuo CL, Chang JH, Wu CC, Shen PH, Wang CC, Lin LC, Shen HC, Lee CH. Treatment of septic knee arthritis: comparison of arthroscopic debridement alone or combined with continuous closed irrigation-suction system. The Journal of Trauma. 71: 454-9. PMID 21045749 DOI: 10.1097/TA.0b013e3181ec4734  0.52
2010 Hu WP, Chen YK, Liao CC, Yu HS, Tsai YM, Huang SM, Tsai FY, Shen HC, Chang LS, Wang JJ. Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents. Bioorganic & Medicinal Chemistry. 18: 6197-207. PMID 20637639 DOI: 10.1016/j.bmc.2010.04.082  0.56
2010 Ding FX, Shen HC, Wilsie LC, Krsmanovic ML, Taggart AK, Ren N, Cai TQ, Wang J, Tong X, Holt TG, Chen Q, Waters MG, Hammond ML, Tata JR, Colletti SL. Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A. Bioorganic & Medicinal Chemistry Letters. 20: 3372-5. PMID 20452209 DOI: 10.1016/j.bmcl.2010.04.013  1
2010 Shen HC. Soluble epoxide hydrolase inhibitors: a patent review. Expert Opinion On Therapeutic Patents. 20: 941-56. PMID 20429668 DOI: 10.1517/13543776.2010.484804  1
2010 Shen HC, Ding FX, Raghavan S, Deng Q, Luell S, Forrest MJ, Carballo-Jane E, Wilsie LC, Krsmanovic ML, Taggart AK, Wu KK, Wu TJ, Cheng K, Ren N, Cai TQ, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. Journal of Medicinal Chemistry. 53: 2666-70. PMID 20184326 DOI: 10.1021/jm100022r  1
2010 Chang JH, Wang SH, Kuo CL, Shen HC, Hong YW, Lin LC. Prevalence of flexible flatfoot in Taiwanese school-aged children in relation to obesity, gender, and age. European Journal of Pediatrics. 169: 447-52. PMID 19756732 DOI: 10.1007/s00431-009-1050-9  0.52
2010 Shen HC, Chang JH, Lee CH, Shen PH, Yeh TT, Wu CC, Kuo CL. Biomechanical comparison of Cross-pin and Endobutton-CL femoral fixation of a flexor tendon graft for anterior cruciate ligament reconstruction--a porcine femur-graft-tibia complex study. The Journal of Surgical Research. 161: 282-7. PMID 19524939 DOI: 10.1016/j.jss.2009.01.015  0.52
2010 Shen HC, Colletti SL. High-Affinity Niacin Receptor GPR109A Agonists Annual Reports in Medicinal Chemistry. 45: 72-94. DOI: 10.1016/S0065-7743(10)45005-8  1
2009 Shen PH, Lien SB, Shen HC, Wang CC, Huang GS, Chao KH, Lee CH, Lin LC. Comparison of different sizes of bioabsorbable interference screws for anterior cruciate ligament reconstruction using bioabsorbable bead augmentation in a porcine model. Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 25: 1101-7. PMID 19801288 DOI: 10.1016/j.arthro.2009.05.011  0.52
2009 Shen HC, Ding FX, Deng Q, Xu S, Tong X, Zhang X, Chen Y, Zhou G, Pai LY, Alonso-Galicia M, Roy S, Zhang B, Tata JR, Berger JP, Colletti SL. A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 5716-21. PMID 19700315 DOI: 10.1016/j.bmcl.2009.08.006  1
2009 Shen HC, Ding FX, Deng Q, Xu S, Chen HS, Tong X, Tong V, Zhang X, Chen Y, Zhou G, Pai LY, Alonso-Galicia M, Zhang B, Roy S, Tata JR, et al. Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 5314-20. PMID 19682899 DOI: 10.1016/j.bmcl.2009.07.138  1
2009 Shen HC, Ding FX, Wang S, Deng Q, Zhang X, Chen Y, Zhou G, Xu S, Chen HS, Tong X, Tong V, Mitra K, Kumar S, Tsai C, Stevenson AS, et al. Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement. Journal of Medicinal Chemistry. 52: 5009-12. PMID 19645482 DOI: 10.1021/jm900725r  1
2009 Wang J, Wang F, Zhang C, Shen HC, Quan L. Linear neighborhood propagation and its applications. Ieee Transactions On Pattern Analysis and Machine Intelligence. 31: 1600-15. PMID 19574621 DOI: 10.1109/TPAMI.2008.216  0.92
2009 Shen HC. Acyl hydroxypyrazoles as novel agonists for high-affinity nicotinic acid receptor GPR109A: WO2008051403. Expert Opinion On Therapeutic Patents. 19: 1149-55. PMID 19566484 DOI: 10.1517/13543770902798061  1
2009 Shen HC, Colletti SL. Novel patent publications on high-affinity nicotinic acid receptor agonists. Expert Opinion On Therapeutic Patents. 19: 957-67. PMID 19552512 DOI: 10.1517/13543770902991526  1
2009 Weng PW, Shen HC, Lee HH, Wu SS, Lee CH. Open reconstruction of large bony glenoid erosion with allogeneic bone graft for recurrent anterior shoulder dislocation. The American Journal of Sports Medicine. 37: 1792-7. PMID 19483076 DOI: 10.1177/0363546509334590  0.52
2009 Shen HC, Ding FX, Wang S, Xu S, Chen HS, Tong X, Tong V, Mitra K, Kumar S, Zhang X, Chen Y, Zhou G, Pai LY, Alonso-Galicia M, Chen X, et al. Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 3398-404. PMID 19481932 DOI: 10.1016/j.bmcl.2009.05.036  1
2009 Chang JH, Shen HC, Huang GS, Pan RY, Wu CF, Lee CH, Chen Q. A biomechanical comparison of all-inside meniscus repair techniques. The Journal of Surgical Research. 155: 82-8. PMID 19328497 DOI: 10.1016/j.jss.2008.10.002  0.52
2009 Shen HC, Ding FX, Deng Q, Wilsie LC, Krsmanovic ML, Taggart AK, Carballo-Jane E, Ren N, Cai TQ, Wu TJ, Wu KK, Cheng K, Chen Q, Wolff MS, Tong X, et al. Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats. Journal of Medicinal Chemistry. 52: 2587-602. PMID 19309152 DOI: 10.1021/jm900151e  1
2009 Wu JL, Yeh TT, Shen HC, Cheng CK, Lee CH. Mechanical comparison of biodegradable femoral fixation devices for hamstring tendon graft--a biomechanical study in a porcine model. Clinical Biomechanics (Bristol, Avon). 24: 435-40. PMID 19303181 DOI: 10.1016/j.clinbiomech.2009.02.003  0.52
2009 Shen HC, Ding FX, Singh SB, Parthasarathy G, Soisson SM, Ha SN, Chen X, Kodali S, Wang J, Dorso K, Tata JR, Hammond ML, Maccoss M, Colletti SL. Synthesis and biological evaluation of platensimycin analogs. Bioorganic & Medicinal Chemistry Letters. 19: 1623-7. PMID 19233644 DOI: 10.1016/j.bmcl.2009.02.006  1
2009 Wang CC, Lien SB, Huang GS, Pan RY, Shen HC, Kuo CL, Shen PH, Lee CH. Arthroscopic elimination of monosodium urate deposition of the first metatarsophalangeal joint reduces the recurrence of gout. Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 25: 153-8. PMID 19171274 DOI: 10.1016/j.arthro.2008.09.002  0.52
2009 Yang DX, Colletti SL, Wu K, Song M, Li GY, Shen HC. Palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters with aryl halides using highly active and air-stable phosphine chloride and oxide ligands. Organic Letters. 11: 381-4. PMID 19072215 DOI: 10.1021/ol802642g  1
2009 Lee HH, Chao KH, Hsieh DS, Shen HC, Chang LW, Wu SS. Blunt lower back injury causes the fracture of sacral zone II and consequently neurogenic bladder. The Journal of Trauma. 67: E5-7. PMID 18349723 DOI: 10.1097/01.ta.0000242785.45944.35  0.52
2009 Shen HC. Asymmetric synthesis of chiral chromans Tetrahedron. 65: 3931-3952. DOI: 10.1016/j.tet.2009.02.002  1
2008 Shen HC, Taggart AK, Wilsie LC, Waters MG, Hammond ML, Tata JR, Colletti SL. Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A. Bioorganic & Medicinal Chemistry Letters. 18: 4948-51. PMID 18752940 DOI: 10.1016/j.bmcl.2008.08.039  1
2008 Raghavan S, Tria GS, Shen HC, Ding FX, Taggart AK, Ren N, Wilsie LC, Krsmanovic ML, Holt TG, Wolff MS, Waters MG, Hammond ML, Tata JR, Colletti SL. Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists. Bioorganic & Medicinal Chemistry Letters. 18: 3163-7. PMID 18477506 DOI: 10.1016/j.bmcl.2008.04.071  1
2008 Wang SH, Lee CH, Shen HC, Chao KH, Pan RY. Nonconcentric reduction by an inverted anterosuperior labrum with avulsed osteocartilaginous fragment in an anterior hip dislocation. Journal of Orthopaedic Trauma. 22: 206-8. PMID 18317056 DOI: 10.1097/BOT.0b013e318160ae08  0.52
2008 Shen HC. Recent advances in syntheses of carbocycles and heterocycles via homogeneous gold catalysis. Part 2: Cyclizations and cycloadditions Tetrahedron. 64: 7847-7870. DOI: 10.1016/j.tet.2008.05.082  1
2008 Shen HC. Recent advances in syntheses of heterocycles and carbocycles via homogeneous gold catalysis. Part 1: Heteroatom addition and hydroarylation reactions of alkynes, allenes, and alkenes Tetrahedron. 64: 3885-3903. DOI: 10.1016/j.tet.2008.01.081  1
2007 Shen HC, Szymonifka MJ, Kharbanda D, Deng Q, Carballo-Jane E, Wu KK, Wu TJ, Cheng K, Ren N, Cai TQ, Taggart AK, Wang J, Tong X, Waters MG, Hammond ML, et al. Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A. Bioorganic & Medicinal Chemistry Letters. 17: 6723-8. PMID 18029181 DOI: 10.1016/j.bmcl.2007.10.055  1
2007 Shen HC, Ding FX, Luell S, Forrest MJ, Carballo-Jane E, Wu KK, Wu TJ, Cheng K, Wilsie LC, Krsmanovic ML, Taggart AK, Ren N, Cai TQ, Deng Q, Chen Q, et al. Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor. Journal of Medicinal Chemistry. 50: 6303-6. PMID 17994679 DOI: 10.1021/jm700942d  1
2007 Minnihan EC, Colletti SL, Toste FD, Shen HC. Gold(I)-catalyzed regioselective cyclizations of silyl ketene amides and carbamates with alkynes. The Journal of Organic Chemistry. 72: 6287-9. PMID 17625890 DOI: 10.1021/jo071014r  1
2006 Shen HC, Ding FX, Colletti SL. Alpha-heteroarylation of esters, lactones, amides, and lactams by nucleophilic aromatic substitution. Organic Letters. 8: 1447-50. PMID 16562913 DOI: 10.1021/ol060246u  1
2005 Trost BM, Shen HC, Horne DB, Toste FD, Steinmetz BG, Koradin C. Syntheses of seven-membered rings: ruthenium-catalyzed intramolecular [5+2] cycloadditions. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 2577-90. PMID 15736147 DOI: 10.1002/chem.200401065  1
2004 Trost BM, Shen HC, Surivet JP. Biomimetic enantioselective total synthesis of (-)-siccanin via the Pd-catalyzed asymmetric allylic alkylation (AAA) and sequential radical cyclizations. Journal of the American Chemical Society. 126: 12565-79. PMID 15453789 DOI: 10.1021/ja048084p  1
2004 Trost BM, Shen HC, Dong L, Surivet JP, Sylvain C. Synthesis of chiral chromans by the Pd-catalyzed asymmetric allylic alkylation (AAA): scope, mechanism, and applications. Journal of the American Chemical Society. 126: 11966-83. PMID 15382932 DOI: 10.1021/ja048078t  1
2003 Trost BM, Shen HC, Schulz T, Koradin C, Schirok H. On the diastereoselectivity of ru-catalyzed [5 + 2] cycloadditions. Organic Letters. 5: 4149-51. PMID 14572271 DOI: 10.1021/ol0355884  1
2003 Trost BM, Shen HC, Surivet JP. An enantioselective biomimetic total synthesis of (-)-siccanin. Angewandte Chemie (International Ed. in English). 42: 3943-7. PMID 12949876 DOI: 10.1002/anie.200351868  1
2003 Trost BM, Shen HC, Dong L, Surivet JP. Unusual effects in the pd-catalyzed asymmetric allylic alkylations: synthesis of chiral chromans. Journal of the American Chemical Society. 125: 9276-7. PMID 12889940 DOI: 10.1021/ja036052g  1
2003 Shen HC, Wang J, Cole KP, McLaughlin MJ, Morgan CD, Douglas CJ, Hsung RP, Coverdale HA, Gerasyuto AI, Hahn JM, Liu J, Sklenicka HM, Wei LL, Zehnder LR, Zificsak CA. A formal [3 + 3] cycloaddition reaction. Improved reactivity using alpha,beta-unsaturated iminium salts and evidence for reversibility of 6pi-electron electrocyclic ring closure of 1-oxatrienes. The Journal of Organic Chemistry. 68: 1729-35. PMID 12608785 DOI: 10.1021/jo020688t  1
2002 Trost BM, Shen HC, Pinkerton AB. A synthesis of trisubstituted alkenes by a Ru-catalyzed addition. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 2341-9. PMID 12012418 DOI: 10.1002/1521-3765(20020517)8:10<2341::AID-CHEM2341>3.0.CO;2-A  1
2001 Trost BM, Shen HC. Constructing Tricyclic Compounds Containing a Seven-Membered Ring by Ruthenium-Catalyzed Intramolecular [5+2] Cycloaddition. Angewandte Chemie (International Ed. in English). 40: 2313-2316. PMID 29711821 DOI: 10.1002/1521-3773(20010618)40:12<2313::AID-ANIE2313>3.0.CO;2-H  1
2001 Zehnder LR, Wei LL, Hsung RP, Cole KP, McLaughlin MJ, Shen HC, Sklenicka HM, Wang J, Zificsak CA. Stereoselective trans- and cis-dihydroxylations of 2H-pyranyl and dihydropyridinyl heterocycles synthesized from formal [3 + 3]-cycloaddition reactions of alpha,beta-unsaturated iminium ions with 1,3-dicarbonyl equivalents. Organic Letters. 3: 2141-4. PMID 11440564 DOI: 10.1021/ol010034r  1
2001 Trost BM, Shen HC. Constructing Tricyclic Compounds Containing a Seven-Membered Ring by Ruthenium-Catalyzed Intramolecular Angewandte Chemie (International Ed. in English). 40: 2313-2316. PMID 11433506 DOI: 10.1002/1521-3773(20010618)40:12<2313::AID-ANIE2313>3.0.CO;2-H  1
2001 McLaughlin MJ, Shen HC, Hsung RP. Chiral cycloalkylidene α,β-unsaturated iminium approach to stereoselective formal [3+3] cycloaddition reaction in spiroheterocycle synthesis Tetrahedron Letters. 42: 609-613. DOI: 10.1016/S0040-4039(00)02018-9  1
2000 Trost BM, Shen HC. On the regioselectivity of the Ru-catalyzed intramolecular [5 + 2] cycloaddition. Organic Letters. 2: 2523-5. PMID 10956537  1
1999 Hsung RP, Shen HC, Douglas CJ, Morgan CD, Degen SJ, Yao LJ. Sequential 1,2-Addition-Electrocyclic Ring Closures Involving Acyclic alpha,beta-Unsaturated Iminiums: A Formal [3 + 3] Cycloaddition Strategy to Unique Pyranyl Spirocycles. The Journal of Organic Chemistry. 64: 690-691. PMID 11674130  0.92
1999 Degen SJ, Mueller KL, Shen HC, Mulder JA, Golding GM, Wei LL, Zificsak CA, Neeno-Eckwall A, Hsung RP. Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin. Bioorganic & Medicinal Chemistry Letters. 9: 973-8. PMID 10230623 DOI: 10.1016/S0960-894X(99)00115-8  1
1999 Hsung RP, Shen HC, Douglas CJ, Morgan CD, Degen SJ, Yao LJ. Sequential 1,2-addition-electrocyclic ring closures involving acyclic α,β-unsaturated iminiums: A formal [3 + 3] cycloaddition strategy to unique pyranyl spirocycles Journal of Organic Chemistry. 64: 690-691. DOI: 10.1021/jo982165k  1
1999 Douglas CJ, Sklenicka HM, Shen HC, Mathias DS, Degen SJ, Golding GM, Morgan CD, Shih RA, Mueller KL, Seurer LM, Johnson EW, Hsung RP. Synthesis and UV studies of a small library of 6-aryl-4-hydroxy-2- pyrones. A relevant structural feature for the inhibitory property of arisugacin against acetylcholinesterase Tetrahedron. 55: 13683-13696. DOI: 10.1016/S0040-4020(99)00847-9  1
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