| Year |
Citation |
Score |
| 2025 |
Danková D, Nielsen AL, Zarda A, Hansen TN, Hesse M, Benová M, Tsiris A, Bartling CRO, Will EJ, Strømgaard K, Moreno-Yruela C, Heinis C, Olsen CA. Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11. Jacs Au. 5: 1299-1307. PMID 40151233 DOI: 10.1021/jacsau.4c01148 |
0.303 |
|
| 2025 |
Nielsen AL, Bartling CRO, Zarda A, De Sadeleer N, Neeser RM, Schwaller P, Strømgaard K, Heinis C. Bulk measurement of membrane permeability for random cyclic peptides in living cells to guide drug development. Angewandte Chemie (International Ed. in English). e202500493. PMID 40052878 DOI: 10.1002/anie.202500493 |
0.433 |
|
| 2024 |
Nielsen AL, Bognar Z, Mothukuri GK, Zarda A, Schuttel M, Merz ML, Ji X, Will E, Chinellato M, Bartling CRO, Stromgaard K, Cendron L, Angelini A, Heinis C. Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation. Angewandte Chemie (International Ed. in English). e202400350. PMID 38602024 DOI: 10.1002/anie.202400350 |
0.442 |
|
| 2024 |
Schüttel M, Will E, Sangouard G, Zarda A, Habeshian S, Nielsen AL, Heinis C. Solid-phase peptide synthesis in 384-well plates. Journal of Peptide Science : An Official Publication of the European Peptide Society. e3555. PMID 38220145 DOI: 10.1002/psc.3555 |
0.517 |
|
| 2023 |
Merz ML, Habeshian S, Li B, David JGL, Nielsen AL, Ji X, Il Khwildy K, Duany Benitez MM, Phothirath P, Heinis C. De novo development of small cyclic peptides that are orally bioavailable. Nature Chemical Biology. PMID 38155304 DOI: 10.1038/s41589-023-01496-y |
0.529 |
|
| 2023 |
Schüttel M, Heinis C. High-Density Immobilization of TCEP on Silica Beads for Efficient Disulfide Reduction and Thiol Alkylation in Peptides. Chembiochem : a European Journal of Chemical Biology. e202300592. PMID 38047532 DOI: 10.1002/cbic.202300592 |
0.436 |
|
| 2023 |
Ji X, Nielsen AL, Heinis C. Cyclic Peptides for Drug Development. Angewandte Chemie (International Ed. in English). e202308251. PMID 37870189 DOI: 10.1002/anie.202308251 |
0.479 |
|
| 2023 |
Liu XY, Ji X, Heinis C, Waser J. Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization. Angewandte Chemie (International Ed. in English). e202306036. PMID 37311172 DOI: 10.1002/anie.202306036 |
0.516 |
|
| 2023 |
Díaz-Perlas C, Ricken B, Farrera-Soler L, Guschin D, Pojer F, Lau K, Gerhold CB, Heinis C. High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays. Nature Communications. 14: 2774. PMID 37198182 DOI: 10.1038/s41467-023-38075-7 |
0.419 |
|
| 2022 |
Bognar Z, Mothukuri GK, Nielsen AL, Merz ML, Pânzar PMF, Heinis C. Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides. Organic & Biomolecular Chemistry. 20: 5699-5703. PMID 35838013 DOI: 10.1039/d2ob00910b |
0.513 |
|
| 2022 |
Gonschorek P, Zorzi A, Maric T, Le Jeune M, Schüttel M, Montagnon M, Gómez-Ojea R, Vollmar DP, Whitfield C, Reymond L, Carle V, Verma H, Schilling O, Hovnanian A, Heinis C. Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their Delivery to the Skin. Journal of Medicinal Chemistry. PMID 35653695 DOI: 10.1021/acs.jmedchem.2c00306 |
0.735 |
|
| 2022 |
Habeshian S, Sable GA, Schüttel M, Merz ML, Heinis C. Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase. Acs Chemical Biology. 17: 181-186. PMID 35015522 DOI: 10.1021/acschembio.1c00843 |
0.473 |
|
| 2021 |
Carle V, Kong XD, Comberlato A, Edwards C, Díaz-Perlas C, Heinis C. Generation of a 100-billion cyclic peptide phage display library having a high skeletal diversity. Protein Engineering, Design & Selection : Peds. 34. PMID 34341825 DOI: 10.1093/protein/gzab018 |
0.781 |
|
| 2021 |
Kong XD, Heinis C. Towards the Development of Orally Available Peptide Therapeutics. Chimia. 75: 514-517. PMID 34233815 DOI: 10.2533/chimia.2021.514 |
0.755 |
|
| 2021 |
Carle V, Wu Y, Mukherjee R, Kong XD, Rogg C, Laurent Q, Cecere E, Villequey C, Konakalla MS, Maric T, Lamers C, Díaz-Perlas C, Butler K, Goto J, Stegmayr B, ... Heinis C, et al. Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation. Journal of Medicinal Chemistry. PMID 33974422 DOI: 10.1021/acs.jmedchem.1c00056 |
0.756 |
|
| 2021 |
Gübeli RJ, Bertoldo D, Shimada K, Gerhold CB, Hurst V, Takahashi Y, Harada K, Mothukuri GK, Wilbs J, Harata M, Gasser SM, Heinis C. -Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4. Acs Chemical Biology. PMID 33843189 DOI: 10.1021/acschembio.0c00825 |
0.315 |
|
| 2021 |
Ceballos J, Grinhagena E, Sangouard G, Heinis C, Waser J. Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents. Angewandte Chemie (International Ed. in English). PMID 33450121 DOI: 10.1002/anie.202014511 |
0.48 |
|
| 2020 |
Kong XD, Carle V, Díaz-Perlas C, Butler K, Heinis C. Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product. Acs Chemical Biology. PMID 33125222 DOI: 10.1021/acschembio.0c00497 |
0.753 |
|
| 2020 |
Wilbs J, Kong XD, Middendorp SJ, Prince R, Cooke A, Demarest CT, Abdelhafez MM, Roberts K, Umei N, Gonschorek P, Lamers C, Deyle K, Rieben R, Cook KE, Angelillo-Scherrer A, ... Heinis C, et al. Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs. Nature Communications. 11: 3890. PMID 32753636 DOI: 10.1038/S41467-020-17648-W |
0.704 |
|
| 2020 |
Kong X, Moriya J, Carle V, Pojer F, Abriata LA, Deyle K, Heinis C. De novo development of proteolytically resistant therapeutic peptides for oral administration Nature Biomedical Engineering. 4: 560-571. PMID 32393891 DOI: 10.1038/S41551-020-0556-3 |
0.763 |
|
| 2020 |
Wu Y, Zorzi A, Williams J, Heinis C. A releasable disulfide-linked peptide tag facilitates the synthesis and purification of short peptides. Chemical Communications (Cambridge, England). PMID 32037436 DOI: 10.1039/c9cc09247a |
0.52 |
|
| 2019 |
Pham MV, Bergeron-Brlek M, Heinis C. Synthesis of DNA-Encoded Disulfide- and Thioether-Cyclized Peptides. Chembiochem : a European Journal of Chemical Biology. 21: 543-549. PMID 31381227 DOI: 10.1002/cbic.201900390 |
0.499 |
|
| 2019 |
Maola K, Wilbs J, Touati J, Sabisz M, Kong X, Baumann A, Deyle K, Heinis C. Engineered Peptide Macrocycles Can Inhibit Matrix Metalloproteinases with High Selectivity Angewandte Chemie. 58: 11801-11805. PMID 31251434 DOI: 10.1002/Anie.201906791 |
0.714 |
|
| 2018 |
Deyle K, Heinis C. Drugs Based on de novo-developed Peptides are Coming of Age mune is a. Chimia. 72: 426-427. PMID 29941082 DOI: 10.2533/Chimia.2018.426 |
0.508 |
|
| 2018 |
Kale SS, Villequey C, Kong XD, Zorzi A, Deyle K, Heinis C. Cyclization of peptides with two chemical bridges affords large scaffold diversities. Nature Chemistry. PMID 29713035 DOI: 10.1038/S41557-018-0042-7 |
0.74 |
|
| 2017 |
Villequey C, Kong XD, Heinis C. Bypassing bacterial infection in phage display by sequencing DNA released from phage particles. Protein Engineering, Design & Selection : Peds. 30: 761-768. PMID 29194551 DOI: 10.1093/protein/gzx057 |
0.644 |
|
| 2017 |
Deyle K, Kong XD, Heinis C. Phage Selection of Cyclic Peptides for Application in Research and Drug Development. Accounts of Chemical Research. PMID 28719188 DOI: 10.1021/Acs.Accounts.7B00184 |
0.788 |
|
| 2017 |
Zorzi A, Middendorp SJ, Wilbs J, Deyle K, Heinis C. Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides. Nature Communications. 8: 16092. PMID 28714475 DOI: 10.1038/Ncomms16092 |
0.453 |
|
| 2017 |
Zorzi A, Deyle K, Heinis C. Cyclic peptide therapeutics: past, present and future. Current Opinion in Chemical Biology. 38: 24-29. PMID 28249193 DOI: 10.1016/J.Cbpa.2017.02.006 |
0.506 |
|
| 2017 |
Liu W, Zheng Y, Kong X, Heinis C, Zhao Y, Wu C. Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction. Angewandte Chemie (International Ed. in English). PMID 28240444 DOI: 10.1002/anie.201610942 |
0.771 |
|
| 2017 |
Middendorp SJ, Wilbs J, Quarroz C, Calzavarini S, Angelillo-Scherrer A, Heinis C. Peptide Macrocycle Inhibitor of Coagulation Factor XII with Subnanomolar Affinity and High Target Selectivity. Journal of Medicinal Chemistry. 60: 1151-1158. PMID 28045547 DOI: 10.1021/acs.jmedchem.6b01548 |
0.359 |
|
| 2016 |
Liskamp RM, Korotkovs V, Bijl J, Wilson C, van de Langemheen H, Kale S, Heinis C. Polar Hinges as Functionalized Conformational Constraints in (Bi)cyclic Peptides. Chembiochem : a European Journal of Chemical Biology. PMID 27982494 DOI: 10.1002/Cbic.201600612 |
0.524 |
|
| 2016 |
Wilbs J, Middendorp SJ, Heinis C. Improving the Binding Affinity of in-Vitro-Evolved Cyclic Peptides by Inserting Atoms into the Macrocycle Backbone. Chembiochem : a European Journal of Chemical Biology. 17: 2299-2303. PMID 27862752 DOI: 10.1002/cbic.201600336 |
0.491 |
|
| 2016 |
Rentero Rebollo I, McCallin S, Bertoldo D, Entenza JM, Moreillon P, Heinis C. Development of Potent and Selective S. aureus Sortase A Inhibitors Based on Peptide Macrocycles. Acs Medicinal Chemistry Letters. 7: 606-11. PMID 27326335 DOI: 10.1021/acsmedchemlett.6b00045 |
0.469 |
|
| 2016 |
Diderich P, Bertoldo D, Dessen P, Khan MM, Pizzitola I, Held W, Huelsken J, Heinis C. Phage selection of chemically stabilized α-helical peptide ligands. Acs Chemical Biology. PMID 26929989 DOI: 10.1021/Acschembio.5B00963 |
0.427 |
|
| 2015 |
Urech-Varenne C, Radtke F, Heinis C. Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor. Chemmedchem. 10: 1754-61. PMID 26381087 DOI: 10.1002/cmdc.201500261 |
0.419 |
|
| 2015 |
Baeriswyl V, Calzavarini S, Chen S, Zorzi A, Bologna L, Angelillo-Scherrer A, Heinis C. A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation. Acs Chemical Biology. 10: 1861-70. PMID 25989088 DOI: 10.1021/acschembio.5b00103 |
0.622 |
|
| 2015 |
Heinis C, Winter G. Encoded libraries of chemically modified peptides. Current Opinion in Chemical Biology. 26: 89-98. PMID 25768886 DOI: 10.1016/j.cbpa.2015.02.008 |
0.722 |
|
| 2015 |
Chen S, Heinis C. Phage selection of bicyclic peptides based on two disulfide bridges. Methods in Molecular Biology (Clifton, N.J.). 1248: 119-37. PMID 25616330 DOI: 10.1007/978-1-4939-2020-4_9 |
0.703 |
|
| 2015 |
Pollaro L, Raghunathan S, Morales-Sanfrutos J, Angelini A, Kontos S, Heinis C. Bicyclic peptides conjugated to an albumin-binding tag diffuse efficiently into solid tumors. Molecular Cancer Therapeutics. 14: 151-61. PMID 25381263 DOI: 10.1158/1535-7163.MCT-14-0534 |
0.338 |
|
| 2014 |
Rentero Rebollo I, Sabisz M, Baeriswyl V, Heinis C. Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides. Nucleic Acids Research. 42: e169. PMID 25348396 DOI: 10.1093/nar/gku940 |
0.495 |
|
| 2014 |
Chen S, Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, Pojer F, Heinis C. Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides. Nature Chemistry. 6: 1009-16. PMID 25343607 DOI: 10.1038/Nchem.2043 |
0.618 |
|
| 2014 |
Bellotto S, Chen S, Rentero Rebollo I, Wegner HA, Heinis C. Phage selection of photoswitchable peptide ligands. Journal of the American Chemical Society. 136: 5880-3. PMID 24702159 DOI: 10.1021/ja501861m |
0.644 |
|
| 2014 |
Diderich P, Heinis C. Directed evolution of bicyclic peptides for therapeutic application. Chimia. 67: 910-5. PMID 24594337 DOI: 10.2533/chimia.2013.910 |
0.536 |
|
| 2014 |
Chen S, Bertoldo D, Angelini A, Pojer F, Heinis C. Peptide ligands stabilized by small molecules. Angewandte Chemie (International Ed. in English). 53: 1602-6. PMID 24453110 DOI: 10.1002/anie.201309459 |
0.68 |
|
| 2014 |
Chen S, Touati J, Heinis C. Tracking chemical reactions on the surface of filamentous phage using mass spectrometry. Chemical Communications (Cambridge, England). 50: 5267-9. PMID 24291807 DOI: 10.1039/c3cc47496h |
0.59 |
|
| 2013 |
Chen S, Gfeller D, Buth SA, Michielin O, Leiman PG, Heinis C. Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids. Chembiochem : a European Journal of Chemical Biology. 14: 1316-22. PMID 23828687 DOI: 10.1002/Cbic.201300228 |
0.64 |
|
| 2013 |
Lee B, Chen S, Heinis C, Scopelliti R, Severin K. Pattern-based sensing of peptides and aminoglycosides with a single molecular probe. Organic Letters. 15: 3456-9. PMID 23796050 DOI: 10.1021/Ol401495C |
0.58 |
|
| 2013 |
Baeriswyl V, Calzavarini S, Gerschheimer C, Diderich P, Angelillo-Scherrer A, Heinis C. Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy. Journal of Medicinal Chemistry. 56: 3742-6. PMID 23586812 DOI: 10.1021/jm400236j |
0.388 |
|
| 2013 |
Chen S, Rentero Rebollo I, Buth SA, Morales-Sanfrutos J, Touati J, Leiman PG, Heinis C. Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries. Journal of the American Chemical Society. 135: 6562-9. PMID 23560397 DOI: 10.1021/Ja400461H |
0.664 |
|
| 2013 |
Baeriswyl V, Heinis C. Polycyclic peptide therapeutics. Chemmedchem. 8: 377-84. PMID 23355488 DOI: 10.1002/cmdc.201200513 |
0.523 |
|
| 2013 |
Rentero Rebollo I, Heinis C. Phage selection of bicyclic peptides. Methods (San Diego, Calif.). 60: 46-54. PMID 23313750 DOI: 10.1016/j.ymeth.2012.12.008 |
0.499 |
|
| 2012 |
Baeriswyl V, Heinis C. Phage selection of cyclic peptide antagonists with increased stability toward intestinal proteases. Protein Engineering, Design & Selection : Peds. 26: 81-9. PMID 23100545 DOI: 10.1093/protein/gzs085 |
0.512 |
|
| 2012 |
Angelini A, Morales-Sanfrutos J, Diderich P, Chen S, Heinis C. Bicyclization and tethering to albumin yields long-acting peptide antagonists. Journal of Medicinal Chemistry. 55: 10187-97. PMID 23088498 DOI: 10.1021/jm301276e |
0.679 |
|
| 2012 |
Angelini A, Diderich P, Morales-Sanfrutos J, Thurnheer S, Hacker D, Menin L, Heinis C. Chemical macrocyclization of peptides fused to antibody Fc fragments. Bioconjugate Chemistry. 23: 1856-63. PMID 22812498 DOI: 10.1021/bc300184m |
0.525 |
|
| 2012 |
Pollaro L, Diderich P, Angelini A, Bellotto S, Wegner H, Heinis C. Measuring net protease activities in biological samples using selective peptidic inhibitors. Analytical Biochemistry. 427: 18-20. PMID 22549049 DOI: 10.1016/J.Ab.2012.04.025 |
0.412 |
|
| 2012 |
Chen S, Morales-Sanfrutos J, Angelini A, Cutting B, Heinis C. Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides. Chembiochem : a European Journal of Chemical Biology. 13: 1032-8. PMID 22492661 DOI: 10.1002/cbic.201200049 |
0.691 |
|
| 2012 |
Baeriswyl V, Rapley H, Pollaro L, Stace C, Teufel D, Walker E, Chen S, Winter G, Tite J, Heinis C. Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases. Chemmedchem. 7: 1173-6. PMID 22492508 DOI: 10.1002/cmdc.201200071 |
0.718 |
|
| 2012 |
Angelini A, Cendron L, Chen S, Touati J, Winter G, Zanotti G, Heinis C. Bicyclic peptide inhibitor reveals large contact interface with a protease target. Acs Chemical Biology. 7: 817-21. PMID 22304751 DOI: 10.1021/cb200478t |
0.777 |
|
| 2012 |
Rentero I, Heinis C. Screening of large molecule diversities by phage display. Chimia. 65: 843-5. PMID 22289368 DOI: 10.2533/chimia.2011.843 |
0.39 |
|
| 2011 |
Takahashi-Umebayashi M, Pineau L, Hannich T, Zumbuehl A, Doval DA, Matile S, Heinis C, Turcatti G, Loewith R, Roux A, Reymond L, Johnsson K, Riezman H. Chemical biology approaches to membrane homeostasis and function. Chimia. 65: 849-52. PMID 22289370 DOI: 10.2533/Chimia.2011.849 |
0.661 |
|
| 2011 |
Heinis C. Bicyclic peptide antagonists derived from genetically encoded combinatorial libraries. Chimia. 65: 677-9. PMID 22026178 DOI: 10.2533/chimia.2011.677 |
0.488 |
|
| 2011 |
Bojkowska K, Santoni de Sio F, Barde I, Offner S, Verp S, Heinis C, Johnsson K, Trono D. Measuring in vivo protein half-life. Chemistry & Biology. 18: 805-15. PMID 21700215 DOI: 10.1016/J.Chembiol.2011.03.014 |
0.494 |
|
| 2011 |
Angelini A, Heinis C. Post-translational modification of genetically encoded polypeptide libraries. Current Opinion in Chemical Biology. 15: 355-61. PMID 21489857 DOI: 10.1016/j.cbpa.2011.03.009 |
0.477 |
|
| 2011 |
Touati J, Angelini A, Hinner MJ, Heinis C. Enzymatic cyclisation of peptides with a transglutaminase. Chembiochem : a European Journal of Chemical Biology. 12: 38-42. PMID 21154802 DOI: 10.1002/cbic.201000451 |
0.501 |
|
| 2010 |
Heinis C, Johnsson K. Using peptide loop insertion mutagenesis for the evolution of proteins. Methods in Molecular Biology (Clifton, N.J.). 634: 217-32. PMID 20676987 DOI: 10.1007/978-1-60761-652-8_16 |
0.666 |
|
| 2009 |
Heinis C, Rutherford T, Freund S, Winter G. Phage-encoded combinatorial chemical libraries based on bicyclic peptides. Nature Chemical Biology. 5: 502-7. PMID 19483697 DOI: 10.1038/nchembio.184 |
0.746 |
|
| 2008 |
Gautier A, Juillerat A, Heinis C, Corrêa IR, Kindermann M, Beaufils F, Johnsson K. An engineered protein tag for multiprotein labeling in living cells. Chemistry & Biology. 15: 128-36. PMID 18291317 DOI: 10.1016/J.Chembiol.2008.01.007 |
0.505 |
|
| 2006 |
Heinis C, Schmitt S, Kindermann M, Godin G, Johnsson K. Evolving the substrate specificity of O6-alkylguanine-DNA alkyltransferase through loop insertion for applications in molecular imaging. Acs Chemical Biology. 1: 575-84. PMID 17168553 DOI: 10.1021/Cb6003146 |
0.532 |
|
| 2006 |
Gronemeyer T, Chidley C, Juillerat A, Heinis C, Johnsson K. Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling. Protein Engineering, Design & Selection : Peds. 19: 309-16. PMID 16638797 DOI: 10.1093/Protein/Gzl014 |
0.522 |
|
| 2005 |
Juillerat A, Heinis C, Sielaff I, Barnikow J, Jaccard H, Kunz B, Terskikh A, Johnsson K. Engineering substrate specificity of O6-alkylguanine-DNA alkyltransferase for specific protein labeling in living cells. Chembiochem : a European Journal of Chemical Biology. 6: 1263-9. PMID 15934048 DOI: 10.1002/Cbic.200400431 |
0.524 |
|
| 2005 |
Heinis C, Johnsson K. Fast directed evolution of non-immunoglobulin proteins by somatic hypermutation in immune cells. Chembiochem : a European Journal of Chemical Biology. 6: 804-6. PMID 15770622 DOI: 10.1002/Cbic.200500011 |
0.468 |
|
| 2004 |
Heinis C, Alessi P, Neri D. Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy. Biochemistry. 43: 6293-303. PMID 15147213 DOI: 10.1021/bi0361160 |
0.599 |
|
| 2003 |
Heinis C, Bertschinger J, Neri D. Calmodulin-tagged phage and two-filter sandwich assays for the identification of enzymatic activities. Methods in Molecular Biology (Clifton, N.J.). 230: 313-28. PMID 12824592 DOI: 10.1385/1-59259-396-8:313 |
0.538 |
|
| 2002 |
Heinis C, Melkko S, Demartis S, Neri D. Two general methods for the isolation of enzyme activities by colony filter screening. Chemistry & Biology. 9: 383-90. PMID 11927264 DOI: 10.1016/s1074-5521(02)00113-8 |
0.565 |
|
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