| Year |
Citation |
Score |
| 2021 |
Cinelli MA, Jones AD. Alkaloids of the Genus : Review of a Rich Resource for Natural Product Discovery. Molecules (Basel, Switzerland). 26. PMID 33946338 DOI: 10.3390/molecules26092629 |
0.333 |
|
| 2020 |
Cinelli MA, Reidl CT, Li H, Chreifi G, Poulos TL, Silverman RB. First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. Journal of Medicinal Chemistry. PMID 32302123 DOI: 10.1021/Acs.Jmedchem.9B01573 |
0.383 |
|
| 2018 |
Nenortas NP, Cinelli MA, Morrell AE, Cushman M, Shapiro TA. Activity of aromathecins against African trypanosomes. Antimicrobial Agents and Chemotherapy. PMID 30104277 DOI: 10.1128/Aac.00786-18 |
0.557 |
|
| 2017 |
Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB. Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Journal of Medicinal Chemistry. PMID 28422508 DOI: 10.1021/Acs.Jmedchem.7B00259 |
0.416 |
|
| 2015 |
Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. Journal of Medicinal Chemistry. PMID 26469213 DOI: 10.1021/Acs.Jmedchem.5B01330 |
0.345 |
|
| 2014 |
Cinelli MA, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition Journal of Medicinal Chemistry. 57: 1513-1530. PMID 24472039 DOI: 10.1021/Jm401838X |
0.388 |
|
| 2012 |
Cinelli MA, Reddy PV, Lv PC, Liang JH, Chen L, Agama K, Pommier Y, van Breemen RB, Cushman M. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. Journal of Medicinal Chemistry. 55: 10844-62. PMID 23215354 DOI: 10.1021/Jm300519W |
0.582 |
|
| 2011 |
Peterson KE, Cinelli MA, Morrell AE, Mehta A, Dexheimer TS, Agama K, Antony S, Pommier Y, Cushman M. Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity. Journal of Medicinal Chemistry. 54: 4937-53. PMID 21710981 DOI: 10.1021/Jm101338Z |
0.576 |
|
| 2010 |
Marler L, Conda-Sheridan M, Cinelli MA, Morrell AE, Cushman M, Chen L, Huang K, Van Breemen R, Pezzuto JM. Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives. Anticancer Research. 30: 4873-82. PMID 21187465 |
0.525 |
|
| 2010 |
Cinelli MA, Morrell AE, Dexheimer TS, Agama K, Agrawal S, Pommier Y, Cushman M. The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode. Bioorganic & Medicinal Chemistry. 18: 5535-52. PMID 20630766 DOI: 10.1016/J.Bmc.2010.06.040 |
0.574 |
|
| 2009 |
Cinelli MA, Cordero B, Dexheimer TS, Pommier Y, Cushman M. Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships. Bioorganic & Medicinal Chemistry. 17: 7145-55. PMID 19783447 DOI: 10.1016/J.Bmc.2009.08.066 |
0.575 |
|
| 2008 |
Cinelli MA, Morrell A, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors. Journal of Medicinal Chemistry. 51: 4609-19. PMID 18630891 DOI: 10.1021/Jm800259E |
0.605 |
|
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