Doug E. Frantz, Ph.D. - Publications

Chemistry The University of Texas at San Antonio, San Antonio, TX, United States 
Practical Synthetic Methodology

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Schneider JW, Oommen S, Qureshi MY, Goetsch SC, Pease DR, Sundsbak RS, Guo W, Sun M, Sun H, Kuroyanagi H, Webster DA, Coutts AW, Holst KA, Edwards BS, Newville N, ... ... Frantz DE, et al. Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs. Nature Medicine. PMID 33188278 DOI: 10.1038/s41591-020-1087-x  0.52
2018 Neff RK, Frantz DE. The Cationic Alkynyl Heck Reaction Towards Substituted Allenes Using BobCat: A New Hybrid Pd(0)-Catalyst Incorporating a Water-Soluble dba Ligand. Journal of the American Chemical Society. PMID 30521312 DOI: 10.1021/jacs.8b11759  0.68
2018 El Arba M, Dibrell SE, Meece F, Frantz DE. Ru(II)-Catalyzed Synthesis of Substituted Furans and Their Conversion to Butenolides. Organic Letters. 20: 5886-5888. PMID 30204453 DOI: 10.1021/acs.orglett.8b02554  0.8
2017 El Arba M, Dibrell SE, Crouch IT, Frantz DE. Unified Approach to Substituted Allenoates via Pd-Catalyzed β-Hydride Elimination of (E)-Enol Triflates. Organic Letters. PMID 28953409 DOI: 10.1021/acs.orglett.7b02736  0.8
2016 Rivera AC, Still R, Frantz DE. Iron-Catalyzed Stereoselective Cross-Coupling Reactions of Stereodefined Enol Carbamates with Grignard Reagents. Angewandte Chemie (International Ed. in English). PMID 27088754 DOI: 10.1002/anie.201601899  0.96
2015 Neff RK, Frantz DE. Recent applications of chiral allenes in axial-to-central chirality transfer reactions Tetrahedron. 71: 7-18. DOI: 10.1016/j.tet.2014.08.030  0.96
2014 Peniche AG, Osorio Y, Renslo AR, Frantz DE, Melby PC, Travi BL. Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major. Antimicrobial Agents and Chemotherapy. 58: 78-87. PMID 24126577 DOI: 10.1128/AAC.00887-13  0.96
2014 Neff RK, Frantz DE. Recent advances in the catalytic syntheses of allenes: A critical assessment Acs Catalysis. 4: 519-528. DOI: 10.1021/cs401007m  0.96
2013 Valentim CL, Cioli D, Chevalier FD, Cao X, Taylor AB, Holloway SP, Pica-Mattoccia L, Guidi A, Basso A, Tsai IJ, Berriman M, Carvalho-Queiroz C, Almeida M, Aguilar H, Frantz DE, et al. Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites. Science (New York, N.Y.). 342: 1385-9. PMID 24263136 DOI: 10.1126/science.1243106  0.96
2013 Risinger AL, Peng J, Rohena CC, Aguilar HR, Frantz DE, Mooberry SL. The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions. Journal of Natural Products. 76: 1923-9. PMID 24087857 DOI: 10.1021/np4005079  0.96
2013 Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, Peña-Llopis S, Xu J, Babinski DJ, Frantz DE, Brekken RA, Quinn AM, Simeonov A, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nature Communications. 4: 2035. PMID 23792809 DOI: 10.1038/ncomms3035  0.96
2013 Crouch IT, Neff RK, Frantz DE. Pd-catalyzed asymmetric β-hydride elimination en route to chiral allenes. Journal of the American Chemical Society. 135: 4970-3. PMID 23488914 DOI: 10.1021/ja401606e  0.96
2013 Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nature Chemical Biology. 9: 271-6. PMID 23434853 DOI: 10.1038/nchembio.1185  0.96
2013 Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. Journal of Medicinal Chemistry. 56: 1739-47. PMID 23363003 DOI: 10.1021/jm301847z  0.96
2012 Babinski DJ, Bao X, El Arba M, Chen B, Hrovat DA, Borden WT, Frantz DE. Synchronized aromaticity as an enthalpic driving force for the aromatic Cope rearrangement. Journal of the American Chemical Society. 134: 16139-42. PMID 22963196 DOI: 10.1021/ja307213m  0.96
2012 Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, et al. Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell. 149: 753-67. PMID 22579281 DOI: 10.1016/j.cell.2012.04.017  0.96
2012 Russell JL, Goetsch SC, Aguilar HR, Coe H, Luo X, Liu N, van Rooij E, Frantz DE, Schneider JW. Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease. Acs Chemical Biology. 7: 1077-83. PMID 22462679 DOI: 10.1021/cb300001m  0.96
2012 Russell JL, Goetsch SC, Aguilar HR, Frantz DE, Schneider JW. Targeting native adult heart progenitors with cardiogenic small molecules. Acs Chemical Biology. 7: 1067-76. PMID 22413910 DOI: 10.1021/cb200525q  0.96
2012 Zang QS, Sadek H, Maass DL, Martinez B, Ma L, Kilgore JA, Williams NS, Frantz DE, Wigginton JG, Nwariaku FE, Wolf SE, Minei JP. Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model. American Journal of Physiology. Heart and Circulatory Physiology. 302: H1847-59. PMID 22408027 DOI: 10.1152/ajpheart.00203.2011  0.96
2012 Hartley RM, Peng J, Fest GA, Dakshanamurthy S, Frantz DE, Brown ML, Mooberry SL. Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site. Molecular Pharmacology. 81: 431-9. PMID 22169850 DOI: 10.1124/mol.111.075838  0.96
2011 Mata MA, Satterly N, Versteeg GA, Frantz D, Wei S, Williams N, Schmolke M, Peña-Llopis S, Brugarolas J, Forst CV, White MA, García-Sastre A, Roth MG, Fontoura BM. Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Nature Chemical Biology. 7: 712-9. PMID 21909097 DOI: 10.1038/nchembio.645  0.96
2011 Babinski DJ, Aguilar HR, Still R, Frantz DE. Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates. The Journal of Organic Chemistry. 76: 5915-23. PMID 21682322 DOI: 10.1021/jo201042c  0.96
2011 Wang Y, Zang QS, Liu Z, Wu Q, Maass D, Dulan G, Shaul PW, Melito L, Frantz DE, Kilgore JA, Williams NS, Terada LS, Nwariaku FE. Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species. American Journal of Physiology. Cell Physiology. 301: C695-704. PMID 21653897 DOI: 10.1152/ajpcell.00322.2010  0.96
2011 Crouch IT, Dreier T, Frantz DE. Palladium-catalyzed elimination/isomerization of enol triflates into 1,3-dienes. Angewandte Chemie (International Ed. in English). 50: 6128-32. PMID 21574234 DOI: 10.1002/anie.201101820  0.96
2011 Zhang L, Li P, Hsu T, Aguilar HR, Frantz DE, Schneider JW, Bachoo RM, Hsieh J. Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation; Research in Biological Diversity. 81: 233-42. PMID 21419563 DOI: 10.1016/j.diff.2011.02.005  0.96
2010 Peng J, Jackson EM, Babinski DJ, Risinger AL, Helms G, Frantz DE, Mooberry SL. Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri. Journal of Natural Products. 73: 1590-2. PMID 20715765 DOI: 10.1021/np100350s  0.96
2009 Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ. An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. The Journal of Biological Chemistry. 284: 9899-907. PMID 19196710 DOI: 10.1074/jbc.M900110200  0.96
2009 Menzel K, Machrouhi F, Bodenstein M, Alorati A, Cowden C, Gibson AW, Bishop B, Ikemoto N, Nelson TD, Kress MH, Frantz DE. Process development of a potent bradykinin 1 antagonist Organic Process Research and Development. 13: 519-524. DOI: 10.1021/op8003184  0.96
2008 Schneider JW, Gao Z, Li S, Farooqi M, Tang TS, Bezprozvanny I, Frantz DE, Hsieh J. Small-molecule activation of neuronal cell fate. Nature Chemical Biology. 4: 408-10. PMID 18552832 DOI: 10.1038/nchembio.95  0.96
2008 Babinski D, Soltani O, Frantz DE. Stereoselective synthesis of acetoacetate-derived enol triflates. Organic Letters. 10: 2901-4. PMID 18540630 DOI: 10.1021/ol8010002  0.96
2008 Sadek H, Hannack B, Choe E, Wang J, Latif S, Garry MG, Garry DJ, Longgood J, Frantz DE, Olson EN, Hsieh J, Schneider JW. Cardiogenic small molecules that enhance myocardial repair by stem cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 6063-8. PMID 18420817 DOI: 10.1073/pnas.0711507105  0.96
2008 Menzel K, Mills PM, Frantz DE, Nelson TD, Kress MH. Substitution effect on the regioselective halogen/metal exchange of 3-substituted 1,2,5-tribromobenzenes Tetrahedron Letters. 49: 415-418. DOI: 10.1016/j.tetlet.2007.11.124  0.96
2007 Chen X, Longgood JC, Michnoff C, Wei S, Frantz DE, Bezprozvanny L. High-throughput screen for small molecule inhibitors of Mint1-PDZ domains. Assay and Drug Development Technologies. 5: 769-83. PMID 18078379 DOI: 10.1089/adt.2007.092  0.96
2006 DiMichele L, Menzel K, Mills P, Frantz D, Nelson T. Halogen-metal exchange of 3-substituted 1,2-dibromoarenes: The use of long-range JCH coupling constants to determine regiochemistry Magnetic Resonance in Chemistry. 44: 1041-1043. PMID 16941579 DOI: 10.1002/mrc.1891  0.96
2006 Menzel K, Fisher EL, Dimichele L, Frantz DE, Nelson TD, Kress MH. An improved method for the bromination of metalated haloarenes via lithium, zinc transmetalation: a convenient synthesis of 1,2-dibromoarenes. The Journal of Organic Chemistry. 71: 2188-91. PMID 16497017 DOI: 10.1021/jo052515k  0.96
2006 Menzel K, Dimichele L, Mills P, Frantz DE, Nelson TD, Kress MH. Regioselective halogen-metal exchange reaction of 3-substituted 1,2-dibromo arenes: The synthesis of 2-substituted 5-bromobenzoic acids Synlett. 1948-1952. DOI: 10.1055/s-2006-947362  0.96
2004 Nelson TD, LeBlond CR, Frantz DE, Matty L, Mitten JV, Weaver DG, Moore JC, Kim JM, Boyd R, Kim PY, Gbewonyo K, Brower M, Sturr M, McLaughlin K, McMasters DR, et al. Stereoselective synthesis of a potent thrombin inhibitor by a novel P2-P3 lactone ring opening. The Journal of Organic Chemistry. 69: 3620-7. PMID 15152989 DOI: 10.1021/jo035794p  0.96
2004 Fässler R, Tomooka CS, Frantz DE, Carreira EM. Infrared spectroscopic investigations on the metallation of terminal alkynes by Zn(OTf)2. Proceedings of the National Academy of Sciences of the United States of America. 101: 5843-5. PMID 15067111 DOI: 10.1073/pnas.0308326101  0.96
2004 Frantz DE, Morency L, Soheili A, Murry JA, Grabowski EJ, Tillyer RD. Synthesis of substituted imidazoles via organocatalysis. Organic Letters. 6: 843-6. PMID 14986989 DOI: 10.1021/ol0498803  0.96
2003 Murry JA, Frantz D, Soheili A, Tillyer R, Grabowski EJJ, Reider PJ. Thiazolium-Catalyzed Cross-Coupling of Aldehydes with Acylimines: A New Method for the Synthesis of α-Amidoketones Chemtracts. 16: 579-586.  0.96
2002 Fässler R, Frantz DE, Oetiker J, Carreira EM. First synthesis of optically pure propargylic N-hydroxylamines by direct, highly diastereoselective addition of terminal alkynes to nitrones. Angewandte Chemie (International Ed. in English). 41: 3054-6. PMID 12203456 DOI: 10.1002/1521-3773(20020816)41:16<3054::AID-ANIE3054>3.0.CO;2-B  0.96
2002 Boyall D, Frantz DE, Carreira EM. Efficient enantioselective additions of terminal alkynes and aldehydes under operationally convenient conditions. Organic Letters. 4: 2605-6. PMID 12123387 DOI: 10.1021/ol026282k  0.96
2001 Murry JA, Frantz DE, Soheili A, Tillyer R, Grabowski EJ, Reider PJ. Synthesis of alpha-amido ketones via organic catalysis: thiazolium-catalyzed cross-coupling of aldehydes with acylimines. Journal of the American Chemical Society. 123: 9696-7. PMID 11572700 DOI: 10.1021/ja0165943  0.96
2001 Frey LF, Marcantonio K, Frantz DE, Murry JA, Tillyer RD, Grabowski EJJ, Reider PJ. Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes Tetrahedron Letters. 42: 6815-6818. DOI: 10.1016/S0040-4039(01)01428-9  0.96
2000 Aschwanden P, Frantz DE, Carreira EM. Synthesis of 2,3-dihydroisoxazoles from propargylic N-hydroxylamines via Zn(II)-catalyzed ring-closure reaction Organic Letters. 2: 2331-3. PMID 10930276  0.96
2000 Frantz DE, Fassler R, Tomooka CS, Carreira EM. The discovery of novel reactivity in the development of C-C bond-forming reactions: in situ generation of zinc acetylides with Zn(II)/R(3)N. Accounts of Chemical Research. 33: 373-81. PMID 10891055 DOI: 10.1021/ar990078o  0.96
2000 Frantz DE, Fässler R, Carreira EM. Facile enantioselective synthesis of propargylic alcohols by direct addition of terminal alkynes to aldehydes [3] Journal of the American Chemical Society. 122: 1806-1807. DOI: 10.1021/ja993838z  0.96
2000 Frantz DE, Singleton DA. Isotope effects and the mechanism of chlorotrimethylsilane-mediated addition of cuprates to enones Journal of the American Chemical Society. 122: 3288-3295. DOI: 10.1021/ja993373c  0.96
2000 Boyall D, López F, Sasaki H, Frantz D, Carreira EM. Enantioselective addition of 2-methyl-3-butyn-2-ol to aldehydes: Preparation of 3-hydroxy-1-butynes Organic Letters. 2: 4233-4236.  0.96
1999 Frantz DE, Singleton DA. Carbometalations of simple alkenes with allyldibromoborane Organic Letters. 1: 485-486. PMID 10822588  0.96
1999 Frantz DE, Fässler R, Carreira EM. Catalytic in situ generation of Zn(II)-alkynilides under mild conditions: A novel C=N addition process utilizing terminal acetylenes [12] Journal of the American Chemical Society. 121: 11245-11246. DOI: 10.1021/ja993074n  0.96
1997 Frantz DE, Singleton DA, Snyder JP. 13C kinetic isotope effects for the addition of lithium dibutylcuprate to cyclohexenone. Reductive elimination is rate-determining Journal of the American Chemical Society. 119: 3383-3384. DOI: 10.1021/ja9636348  0.96
1996 Singleton DA, Waller SC, Zhang Z, Frantz DE, Leung SW. Allylboration of alkenes with allyldihaloboranes Journal of the American Chemical Society. 118: 9986-9987. DOI: 10.1021/ja961616k  0.96
Show low-probability matches.