Dena B. Dubal - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 
Area:
Aging, Alzheimers, stroke, neurodegenerative disease, klotho, longevity, sex chromosomes, X chromosome, estrogen
Website:
http://www.duballab.org

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lopez-Lee C, Kodama L, Fan L, Wong MY, Foxe NR, Jiaz L, Yu F, Ye P, Zhu J, Norman K, Torres ER, Kim RD, Mousa GA, Dubal D, Liddelow S, et al. Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging. Biorxiv : the Preprint Server For Biology. PMID 37781600 DOI: 10.1101/2023.09.19.558439  0.493
2023 Saloner R, VandeVrede L, Asken BM, Paolillo EW, Gontrum EQ, Wolf A, Lario-Lago A, Milà-Alomà M, Triana-Baltzer G, Kolb HC, Dubal DB, Rabinovici GD, Miller BL, Boxer AL, Casaletto KB, et al. Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37639492 DOI: 10.1002/alz.13454  0.527
2023 Park C, Hahn O, Gupta S, Moreno AJ, Marino F, Kedir B, Wang D, Villeda SA, Wyss-Coray T, Dubal DB. Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice. Nature Aging. PMID 37587231 DOI: 10.1038/s43587-023-00468-0  0.49
2022 Rabinovici GD, Dubal DB. Rare APOE Missense Variants-Can We Overcome APOE ε4 and Alzheimer Disease Risk? Jama Neurology. PMID 35639398 DOI: 10.1001/jamaneurol.2022.0854  0.41
2022 Gupta S, Moreno AJ, Wang D, Leon J, Chen C, Hahn O, Poon Y, Greenberg K, David N, Wyss-Coray T, Raftery D, Promislow DEL, Dubal DB. KL1 domain of longevity factor klotho mimics the metabolome of cognitive stimulation and enhances cognition in young and aging mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35428698 DOI: 10.1523/JNEUROSCI.2458-21.2022  0.489
2020 Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, ... ... Dubal DB, et al. A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease. Science Translational Medicine. 12. PMID 32848093 DOI: 10.1126/Scitranslmed.Aaz5677  0.746
2020 Casaletto KB, Lindbergh C, Memel M, Staffaroni A, Elahi F, Weiner-Light S, You M, Fonseca C, Karydas A, Jacobs E, Dubal DB, Yaffe K, Kramer JH. Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning. Brain, Behavior, and Immunity. PMID 32387511 DOI: 10.1016/J.Bbi.2020.05.014  0.307
2019 Dubal DB. Pathways to brain resilience. Nature Medicine. 25: 1027. PMID 31270494 DOI: 10.1038/s41591-019-0502-7  0.318
2019 Casaletto KB, Elahi FM, Staffaroni AM, Walters S, Contreras WR, Wolf A, Dubal D, Miller B, Yaffe K, Kramer JH. Cognitive aging is not created equally: differentiating unique cognitive phenotypes in "normal" adults. Neurobiology of Aging. 77: 13-19. PMID 30772736 DOI: 10.1016/J.Neurobiolaging.2019.01.007  0.411
2018 Broestl L, Worden K, Moreno AJ, Davis EJ, Wang D, Garay B, Singh T, Verret L, Palop JJ, Dubal DB. Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Network Alterations in Female Mice. Eneuro. 5. PMID 30627643 DOI: 10.1523/ENEURO.0132-17.2018  0.638
2018 Davis EJ, Lobach I, Dubal DB. Female XX sex chromosomes increase survival and extend lifespan in aging mice. Aging Cell. e12871. PMID 30560587 DOI: 10.1111/Acel.12871  0.329
2018 Dubal DB. The Way of Tau: Secretion and Synaptic Dysfunction. Trends in Molecular Medicine. PMID 29807705 DOI: 10.1016/j.molmed.2018.05.006  0.305
2017 Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal DB. Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice. Cell Reports. 20: 1360-1371. PMID 28793260 DOI: 10.1016/J.Celrep.2017.07.024  0.375
2017 Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, Carlsson CM, Gallagher CL, Hogan KJ, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Dubal DB, et al. BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention. Neurology. PMID 28468845 DOI: 10.1212/Wnl.0000000000003980  0.337
2016 Yokoyama JS, Marx G, Brown JA, Bonham LW, Wang D, Coppola G, Seeley WW, Rosen HJ, Miller BL, Kramer JH, Dubal DB. Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging. Brain Imaging and Behavior. PMID 27714549 DOI: 10.1007/S11682-016-9598-2  0.602
2016 Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC. Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27692800 DOI: 10.1016/J.Jalz.2016.08.004  0.322
2015 Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Ho K, Yu GQ, Vossel KA, Mucke L. Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Annals of Clinical and Translational Neurology. 2: 1012-28. PMID 26732627 DOI: 10.1002/Acn3.257  0.707
2015 Yokoyama JS, Sturm VE, Bonham LW, Klein E, Arfanakis K, Yu L, Coppola G, Kramer JH, Bennett DA, Miller BL, Dubal DB. Variation in longevity gene KLOTHO is associated with greater cortical volumes. Annals of Clinical and Translational Neurology. 2: 215-30. PMID 25815349 DOI: 10.1002/Acn3.161  0.473
2015 Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2358-71. PMID 25673831 DOI: 10.1523/Jneurosci.5791-12.2015  0.577
2015 Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nature Neuroscience. 18: 423-34. PMID 25622143 DOI: 10.1038/Nn.3930  0.566
2014 Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, et al. Life extension factor klotho enhances cognition. Cell Reports. 7: 1065-76. PMID 24813892 DOI: 10.1016/J.Celrep.2014.03.076  0.614
2012 Dubal DB, Broestl L, Worden K. Sex and gonadal hormones in mouse models of Alzheimer's disease: what is relevant to the human condition? Biology of Sex Differences. 3: 24. PMID 23126652 DOI: 10.1186/2042-6410-3-24  0.355
2012 Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. Plos One. 7: e45881. PMID 23029293 DOI: 10.1371/Journal.Pone.0045881  0.654
2011 Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature. 469: 47-52. PMID 21113149 DOI: 10.1038/Nature09635  0.66
2009 Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L. Collagen VI protects neurons against Abeta toxicity. Nature Neuroscience. 12: 119-21. PMID 19122666 DOI: 10.1038/Nn.2240  0.71
2008 Dubal DB, Cheng J, Legleiter J, Wilkins S, Bonaldo P, Yu G, Mucke L. P1-465: Role of collagen VI in Alzheimer's disease: Potential mechanisms of protection Alzheimer's & Dementia. 4: T356-T356. DOI: 10.1016/J.Jalz.2008.05.1048  0.541
2006 Dubal DB, Rau SW, Shughrue PJ, Zhu H, Yu J, Cashion AB, Suzuki S, Gerhold LM, Bottner MB, Dubal SB, Merchanthaler I, Kindy MS, Wise PM. Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death. Endocrinology. 147: 3076-84. PMID 16527848 DOI: 10.1210/En.2005-1177  0.758
2006 Böttner M, Dubal DB, Rau SW, Suzuki S, Wise PM. Stroke injury in rats causes an increase in activin A gene expression which is unaffected by oestradiol treatment. Journal of Neuroendocrinology. 18: 97-103. PMID 16420278 DOI: 10.1111/j.1365-2826.2005.01384.x  0.738
2005 Wise PM, Dubal DB, Rau SW, Brown CM, Suzuki S. Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative. Endocrine Reviews. 26: 308-12. PMID 15851820 DOI: 10.1210/er.2004-0014  0.779
2004 Böttner M, Dubal D, Rau S, Wise P. Activin gene expression increases after stroke injury: Modulation by estradiol Experimental and Clinical Endocrinology & Diabetes. 112. DOI: 10.1055/S-2004-819199  0.709
2004 Wise PM, Dubal DB, Rau SW, Cashion AB. Mechanisms of sex-based neuropathologies Advances in Molecular and Cell Biology. 34: 281-294. DOI: 10.1016/S1569-2558(03)34019-6  0.76
2003 Rau SW, Dubal DB, Böttner M, Gerhold LM, Wise PM. Estradiol attenuates programmed cell death after stroke-like injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 11420-6. PMID 14673006 DOI: 10.1523/Jneurosci.23-36-11420.2003  0.783
2003 Rau SW, Dubal DB, Böttner M, Wise PM. Estradiol differentially regulates c-Fos after focal cerebral ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10487-94. PMID 14627632 DOI: 10.1523/Jneurosci.23-33-10487.2003  0.751
2002 Dubal DB, Wise PM. Estrogen and neuroprotection: from clinical observations to molecular mechanisms. Dialogues in Clinical Neuroscience. 4: 149-61. PMID 22034440  0.607
2002 Wise PM, Smith MJ, Dubal DB, Wilson ME, Rau SW, Cashion AB, Böttner M, Rosewell KL. Neuroendocrine modulation and repercussions of female reproductive aging. Recent Progress in Hormone Research. 57: 235-56. PMID 12017546 DOI: 10.1210/Rp.57.1.235  0.781
2001 Dubal DB, Wise PM. Neuroprotective Effects of Estradiol in Middle-Aged Female Rats** Supported in part by NIH Grant AG-02224 (to P.M.W.), NIH Predoctoral fellowship T32-AG-00242 (to D.B.D.), Merck/American Federation for Aging Research Scholarship (to D.B.D.), and Glenn Foundation/American Federation for Aging Research Scholarship (to D.B.D.). Some of these data were presented in a minireview that summarized a symposium contribution by PMW (1 ). Endocrinology. 142: 43-48. PMID 28201350 DOI: 10.1210/endo.142.1.7911  0.449
2001 Wise PM, Dubal DB, Wilson ME, Rau SW, Bo Ttner M. Minireview: Neuroprotective Effects of Estrogen-New Insights into Mechanisms of Action. Endocrinology. 142: 969-973. PMID 28201240 DOI: 10.1210/endo.142.3.8033  0.682
2001 Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M, Rosewell KL. Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies. Brain Research. Brain Research Reviews. 37: 313-9. PMID 11744096 DOI: 10.1016/S0165-0173(01)00136-9  0.776
2001 Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M. Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action. Endocrinology. 142: 969-73. PMID 11181507 DOI: 10.1210/Endo.142.3.8033  0.772
2001 Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proceedings of the National Academy of Sciences of the United States of America. 98: 1952-7. PMID 11172057 DOI: 10.1073/Pnas.041483198  0.745
2001 Dubal DB, Wise PM. Neuroprotective effects of estradiol in middle-aged female rats. Endocrinology. 142: 43-8. PMID 11145565 DOI: 10.1210/endo.142.1.7911  0.663
2001 Wise PM, Dubal DB, Wilson ME, Rau SW, Liu Y. Estrogens: trophic and protective factors in the adult brain. Frontiers in Neuroendocrinology. 22: 33-66. PMID 11141318 DOI: 10.1006/Frne.2000.0207  0.738
2000 Wise PM, Dubal DB, Wilson ME, Rau SW. Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury. Journal of Neurocytology. 29: 401-10. PMID 11424956 DOI: 10.1023/A:1007169408561  0.763
2000 Wise PM, Dubal DB. Estradiol protects against ischemic brain injury in middle-aged rats. Biology of Reproduction. 63: 982-5. PMID 10993817 DOI: 10.1095/Biolreprod63.4.982  0.694
2000 Wilson ME, Dubal DB, Wise PM. Estradiol protects against injury-induced cell death in cortical explant cultures: a role for estrogen receptors. Brain Research. 873: 235-42. PMID 10930549 DOI: 10.1016/S0006-8993(00)02479-3  0.657
2000 Wise PM, Dubal D, Wilson ME, Rau SW. Neuroprotective actions of estradiol in the adult and aging brain: Potential mechanisms of action Neurobiology of Aging. 21: 212-213. DOI: 10.1016/S0197-4580(00)83285-6  0.598
1999 Dubal DB, Wilson ME, Wise PM. Estradiol: a protective and trophic factor in the brain. Journal of Alzheimer's Disease : Jad. 1: 265-74. PMID 12214124 DOI: 10.3233/Jad-1999-14-507  0.647
1999 Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM. Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6385-93. PMID 10414967 DOI: 10.1523/Jneurosci.19-15-06385.1999  0.677
1999 Wise PM, Smith MJ, Dubal DB, Wilson ME, Krajnak KM, Rosewell KL. Neuroendocrine influences and repercussions of the menopause. Endocrine Reviews. 20: 243-8. PMID 10368769 DOI: 10.1210/Edrv.20.3.0364  0.645
1998 Dubal DB, Kashon ML, Pettigrew LC, Ren JM, Finklestein SP, Rau SW, Wise PM. Estradiol protects against ischemic injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 18: 1253-8. PMID 9809515 DOI: 10.1097/00004647-199811000-00012  0.784
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