| Year |
Citation |
Score |
| 2024 |
Ganegamage SK, Ademoye TA, Patel H, Alnakhala H, Tripathi A, Nguyen CCD, Pham K, Plascencia-Villa G, Zhu X, Perry G, Tian S, Dettmer U, Lasagna-Reeves C, Fortin JS. Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics. Acs Chemical Neuroscience. PMID 39436010 DOI: 10.1021/acschemneuro.4c00282 |
0.638 |
|
| 2024 |
Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, et al. A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features. Medrxiv : the Preprint Server For Health Sciences. PMID 39399048 DOI: 10.1101/2024.09.23.24313864 |
0.754 |
|
| 2024 |
Eubanks E, VanderSleen K, Mody J, Patel N, Sacks B, Farahani MD, Wang J, Elliott J, Jaber N, Akçimen F, Bandres-Ciga S, Helweh F, Liu J, Archakam S, Kimelman R, ... ... Dettmer U, et al. Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease. Biorxiv : the Preprint Server For Biology. PMID 39257816 DOI: 10.1101/2024.08.30.610195 |
0.33 |
|
| 2024 |
Li B, Dettmer U. Interactions of alpha-synuclein with membranes in Parkinson's disease: Mechanisms and therapeutic strategies. Neurobiology of Disease. 106646. PMID 39181187 DOI: 10.1016/j.nbd.2024.106646 |
0.425 |
|
| 2024 |
Tripathi A, Alnakhala H, Brontesi L, Selkoe D, Dettmer U. RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy. Cellular and Molecular Life Sciences : Cmls. 81: 362. PMID 39162859 DOI: 10.1007/s00018-024-05373-2 |
0.605 |
|
| 2024 |
Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, ... ... Dettmer U, et al. Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions. Neuron. PMID 39079530 DOI: 10.1016/j.neuron.2024.06.002 |
0.804 |
|
| 2024 |
Barbuti PA, Guardia-Laguarta C, Yun T, Chatila ZK, Flowers X, Santos BF, Larsen SB, Hattori N, Bradshaw E, Dettmer U, Fanning S, Vilas M, Reddy H, Teich AF, Krüger R, et al. The Role of Alpha-Synuclein in Synucleinopathy: Impact on Lipid Regulation at Mitochondria-ER Membranes. Biorxiv : the Preprint Server For Biology. PMID 38948777 DOI: 10.1101/2024.06.17.599406 |
0.35 |
|
| 2024 |
Ramalingam N, Haass C, Dettmer U. Physiological roles of α-synuclein serine-129 phosphorylation - not an oxymoron. Trends in Neurosciences. 47: 480-490. PMID 38862330 DOI: 10.1016/j.tins.2024.05.005 |
0.83 |
|
| 2024 |
White AJ, Clark KA, Alexander KD, Ramalingam N, Young-Pearse TL, Dettmer U, Selkoe DJ, Ho GPH. A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons. Npj Parkinson's Disease. 10: 107. PMID 38773105 DOI: 10.1038/s41531-024-00725-y |
0.795 |
|
| 2024 |
Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. Npj Parkinson's Disease. 10: 57. PMID 38472218 DOI: 10.1038/s41531-024-00675-5 |
0.707 |
|
| 2024 |
Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. Npj Parkinson's Disease. 10: 47. PMID 38424059 DOI: 10.1038/s41531-024-00662-w |
0.723 |
|
| 2024 |
Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Zami A, Ostafe R, Dettmer U, Fortin JS. Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils. Bioorganic & Medicinal Chemistry. 100: 117613. PMID 38330847 DOI: 10.1016/j.bmc.2024.117613 |
0.795 |
|
| 2023 |
Ganegamage SK, Ramirez E, Alnakhala H, Tripathi A, Nguyen CCD, Zami A, Ostafe R, Tian S, Dettmer U, Fortin JS. 1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α-Synuclein Oligomer Formation . Acs Omega. 9: 1216-1229. PMID 38222653 DOI: 10.1021/acsomega.3c07453 |
0.792 |
|
| 2023 |
Shimanaka K, Shi B, Brontesi L, Alnakhala H, Jayanthi V, Subramanian K, Ramalingam N, Tripathi A, Dettmer U. Adding hydrophobicity or positive charges to the cytosolic half of the α-synuclein 3-11 helix increases membrane association and S129 phosphorylation. Febs Letters. PMID 37989349 DOI: 10.1002/1873-3468.14773 |
0.795 |
|
| 2023 |
Ramalingam N, Dettmer U. α-Synuclein serine129 phosphorylation - the physiology of pathology. Molecular Neurodegeneration. 18: 84. PMID 37953316 DOI: 10.1186/s13024-023-00680-x |
0.752 |
|
| 2023 |
Ramalingam N, Brontesi L, Jin SX, Selkoe DJ, Dettmer U. Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models. Embo Reports. e57145. PMID 37870370 DOI: 10.15252/embr.202357145 |
0.821 |
|
| 2023 |
Wang T, Sun Y, Dettmer U. Astrocytes in Parkinson's Disease: From Role to Possible Intervention. Cells. 12. PMID 37830550 DOI: 10.3390/cells12192336 |
0.309 |
|
| 2023 |
Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, ... Dettmer U, et al. Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation. Acs Chemical Neuroscience. PMID 37818657 DOI: 10.1021/acschemneuro.3c00464 |
0.761 |
|
| 2023 |
Ramirez E, Min S, Ganegamage SK, Shimanaka K, Sosa MG, Dettmer U, Rochet JC, Fortin JS. Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation. Results in Chemistry. 5. PMID 37346091 DOI: 10.1016/j.rechem.2023.100938 |
0.732 |
|
| 2023 |
Ramirez E, Ganegamage SK, Elbatrawy AA, Alnakhala H, Shimanaka K, Tripathi A, Min S, Rochet JC, Dettmer U, Fortin JS. 5-Nitro-1,2-benzothiazol-3-amine and -Ethyl-1-[(ethylcarbamoyl)(5-nitro-1,2-benzothiazol-3-yl)amino]formamide Modulate α-Synuclein and Tau Aggregation. Acs Omega. 8: 20102-20115. PMID 37305264 DOI: 10.1021/acsomega.3c02668 |
0.782 |
|
| 2023 |
Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, ... ... Dettmer U, et al. Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. Npj Parkinson's Disease. 9: 4. PMID 36646701 DOI: 10.1038/s41531-023-00444-w |
0.805 |
|
| 2023 |
Brontesi L, Imberdis T, Ramalingam N, Dettmer U. The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly. Journal of Neurochemistry. PMID 36625497 DOI: 10.1111/jnc.15763 |
0.75 |
|
| 2022 |
Fortin JS, Shimanaka K, Saraswati AP, Liu M, Wang KW, Hagar HT, Maity S, Ganegamage SK, Ellsworth E, Counts SE, Borhan B, Dettmer U, Kuo MH. Anti-fibrillization effects of sulfonamide derivatives on -synuclein and hyperphosphorylated tau isoform 1N4R. Journal of Molecular Structure. 1267. PMID 36310922 DOI: 10.1016/j.molstruc.2022.133574 |
0.675 |
|
| 2022 |
Fonseca-Ornelas L, Stricker JMS, Soriano-Cruz S, Weykopf B, Dettmer U, Muratore CR, Scherzer CR, Selkoe DJ. Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons. Npj Parkinson's Disease. 8: 118. PMID 36114228 DOI: 10.1038/s41531-022-00380-1 |
0.684 |
|
| 2022 |
Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, et al. Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 35792968 DOI: 10.1007/s13311-022-01268-x |
0.596 |
|
| 2022 |
Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, et al. Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. Npj Parkinson's Disease. 8: 74. PMID 35680956 DOI: 10.1038/s41531-022-00335-6 |
0.494 |
|
| 2022 |
Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neve E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, et al. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 35445353 DOI: 10.1007/s13311-022-01199-7 |
0.684 |
|
| 2022 |
de Boni L, Watson AH, Zaccagnini L, Wallis A, Zhelcheska K, Kim N, Sanderson J, Jiang H, Martin E, Cantlon A, Rovere M, Liu L, Sylvester M, Lashley T, Dettmer U, et al. Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations. Acta Neuropathologica. PMID 35141810 DOI: 10.1007/s00401-022-02406-7 |
0.812 |
|
| 2022 |
Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Pathogenic mechanisms of cytosolic and membrane-enriched α-synuclein converge on fatty acid homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35086904 DOI: 10.1523/JNEUROSCI.1881-21.2022 |
0.779 |
|
| 2021 |
Tripathi A, Fanning S, Dettmer U. Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies? Biomolecules. 12. PMID 35053188 DOI: 10.3390/biom12010040 |
0.606 |
|
| 2021 |
Glajch KE, Moors TE, Chen Y, Bechade PA, Nam AY, Rajsombath MM, McCaffery TD, Dettmer U, Weihofen A, Hirst WD, Selkoe DJ, Nuber S. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34326260 DOI: 10.1073/pnas.2103425118 |
0.675 |
|
| 2021 |
Kim TE, Newman AJ, Imberdis T, Brontesi L, Tripathi A, Ramalingam N, Fanning S, Selkoe D, Dettmer U. Excess membrane binding of monomeric alpha-, beta-, and gamma-synuclein is invariably associated with inclusion formation and toxicity. Human Molecular Genetics. PMID 34254125 DOI: 10.1093/hmg/ddab188 |
0.823 |
|
| 2021 |
Ericsson M, von Saucken V, Newman A, Doehr L, Hoesch C, Kim TE, Dettmer U. Crowded Organelles, Lipid Accumulation, and Abnormal Membrane Tubulation in Cellular Models of Enhanced α-Synuclein Membrane Interaction. Brain Research. 147349. PMID 33571519 DOI: 10.1016/j.brainres.2021.147349 |
0.391 |
|
| 2021 |
Ramalingam N, Dettmer U. Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons. The Journal of Biological Chemistry. 296: 100271. PMID 33428933 DOI: 10.1016/j.jbc.2021.100271 |
0.76 |
|
| 2020 |
Ho GPH, Ramalingam N, Imberdis T, Wilkie EC, Dettmer U, Selkoe DJ. Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33103814 DOI: 10.1002/mds.28346 |
0.828 |
|
| 2020 |
Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, et al. A stearoyl-CoA desaturase inhibitor prevents multiple Parkinson's disease-phenotypes in α-synuclein mice. Annals of Neurology. PMID 32996158 DOI: 10.1002/ana.25920 |
0.696 |
|
| 2020 |
Terry-Kantor E, Tripathi A, Imberdis T, LaVoie ZM, Ho GPH, Selkoe D, Fanning S, Ramalingam N, Dettmer U. Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor. International Journal of Molecular Sciences. 21. PMID 32707907 DOI: 10.3390/ijms21155193 |
0.821 |
|
| 2020 |
Fanning S, Selkoe D, Dettmer U. Vesicle trafficking and lipid metabolism in synucleinopathy. Acta Neuropathologica. PMID 32607605 DOI: 10.1007/s00401-020-02177-z |
0.673 |
|
| 2020 |
Kayed R, Dettmer U, Lesné SE. Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk. Journal of Parkinson's Disease. PMID 32508330 DOI: 10.3233/Jpd-201965 |
0.351 |
|
| 2020 |
Fanning S, Selkoe D, Dettmer U. Parkinson's disease: proteinopathy or lipidopathy? Npj Parkinson's Disease. 6: 3. PMID 31909184 DOI: 10.1038/s41531-019-0103-7 |
0.644 |
|
| 2019 |
Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase. Proceedings of the National Academy of Sciences of the United States of America. PMID 31548371 DOI: 10.1073/Pnas.1903216116 |
0.83 |
|
| 2019 |
Yeboah F, Kim TE, Bill A, Dettmer U. Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. Neurobiology of Disease. 104543. PMID 31351173 DOI: 10.1016/j.nbd.2019.104543 |
0.383 |
|
| 2019 |
Imberdis T, Fanning S, Newman A, Ramalingam N, Dettmer U. Studying α-Synuclein Conformation by Intact-Cell Cross-Linking. Methods in Molecular Biology (Clifton, N.J.). 1948: 77-91. PMID 30771172 DOI: 10.1007/978-1-4939-9124-2_8 |
0.756 |
|
| 2018 |
Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, ... ... Dettmer U, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Molecular Cell. PMID 30527540 DOI: 10.1016/J.Molcel.2018.11.028 |
0.819 |
|
| 2018 |
Dettmer U. Rationally Designed Variants of α-Synuclein Illuminate Its Structural Properties in Health and Disease. Frontiers in Neuroscience. 12: 623. PMID 30319334 DOI: 10.3389/fnins.2018.00623 |
0.403 |
|
| 2018 |
Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 100: 75-90.e5. PMID 30308173 DOI: 10.1016/j.neuron.2018.09.014 |
0.684 |
|
| 2017 |
Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Human Molecular Genetics. 26: 3466-3481. PMID 28911198 DOI: 10.1093/hmg/ddx227 |
0.813 |
|
| 2017 |
Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, et al. Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiology of Disease. PMID 28711409 DOI: 10.1016/J.Nbd.2017.07.007 |
0.432 |
|
| 2015 |
Dettmer U, Selkoe D, Bartels T. New insights into cellular α-synuclein homeostasis in health and disease. Current Opinion in Neurobiology. 36: 15-22. PMID 26282834 DOI: 10.1016/j.conb.2015.07.007 |
0.814 |
|
| 2015 |
Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nature Communications. 6: 8008. PMID 26224447 DOI: 10.1038/ncomms9008 |
0.801 |
|
| 2015 |
Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: 9596-601. PMID 26153422 DOI: 10.1073/pnas.1505953112 |
0.83 |
|
| 2015 |
Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nature Communications. 6: 7314. PMID 26076669 DOI: 10.1038/Ncomms8314 |
0.815 |
|
| 2015 |
Dettmer U, Bartels T. ExPLAining early synucleinopathies. Brain : a Journal of Neurology. 138: 1449-51. PMID 26013805 DOI: 10.1093/brain/awv099 |
0.652 |
|
| 2015 |
Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity. Biochemistry. 54: 279-92. PMID 25490121 DOI: 10.1021/bi501188a |
0.749 |
|
| 2014 |
Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Defining the native state of α-synuclein Neurodegenerative Diseases. 13: 114-117. PMID 24192542 DOI: 10.1159/000355516 |
0.809 |
|
| 2013 |
Newman AJ, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous α-synuclein. Plos One. 8: e81314. PMID 24278419 DOI: 10.1371/journal.pone.0081314 |
0.623 |
|
| 2013 |
Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells. The Journal of Biological Chemistry. 288: 6371-85. PMID 23319586 DOI: 10.1074/jbc.M112.403311 |
0.789 |
|
| 2010 |
Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. The Journal of Biological Chemistry. 285: 26174-81. PMID 20538592 DOI: 10.1074/Jbc.M110.132548 |
0.553 |
|
| 2007 |
Haffner C, Dettmer U, Weiler T, Haass C. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. The Journal of Biological Chemistry. 282: 10632-8. PMID 17261586 DOI: 10.1074/Jbc.M611033200 |
0.563 |
|
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