Ulf Dettmer - Publications

Affiliations: 
Neurology Harvard Medical School/Brigham and Women's Hospital 

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ganegamage SK, Ademoye TA, Patel H, Alnakhala H, Tripathi A, Nguyen CCD, Pham K, Plascencia-Villa G, Zhu X, Perry G, Tian S, Dettmer U, Lasagna-Reeves C, Fortin JS. Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics. Acs Chemical Neuroscience. PMID 39436010 DOI: 10.1021/acschemneuro.4c00282  0.638
2024 Brücke C, Al-Azzani M, Ramalingam N, Ramón M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernández CO, Dettmer U, et al. A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features. Medrxiv : the Preprint Server For Health Sciences. PMID 39399048 DOI: 10.1101/2024.09.23.24313864  0.754
2024 Eubanks E, VanderSleen K, Mody J, Patel N, Sacks B, Farahani MD, Wang J, Elliott J, Jaber N, Akçimen F, Bandres-Ciga S, Helweh F, Liu J, Archakam S, Kimelman R, ... ... Dettmer U, et al. Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease. Biorxiv : the Preprint Server For Biology. PMID 39257816 DOI: 10.1101/2024.08.30.610195  0.33
2024 Li B, Dettmer U. Interactions of alpha-synuclein with membranes in Parkinson's disease: Mechanisms and therapeutic strategies. Neurobiology of Disease. 106646. PMID 39181187 DOI: 10.1016/j.nbd.2024.106646  0.425
2024 Tripathi A, Alnakhala H, Brontesi L, Selkoe D, Dettmer U. RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy. Cellular and Molecular Life Sciences : Cmls. 81: 362. PMID 39162859 DOI: 10.1007/s00018-024-05373-2  0.605
2024 Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, ... ... Dettmer U, et al. Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions. Neuron. PMID 39079530 DOI: 10.1016/j.neuron.2024.06.002  0.804
2024 Barbuti PA, Guardia-Laguarta C, Yun T, Chatila ZK, Flowers X, Santos BF, Larsen SB, Hattori N, Bradshaw E, Dettmer U, Fanning S, Vilas M, Reddy H, Teich AF, Krüger R, et al. The Role of Alpha-Synuclein in Synucleinopathy: Impact on Lipid Regulation at Mitochondria-ER Membranes. Biorxiv : the Preprint Server For Biology. PMID 38948777 DOI: 10.1101/2024.06.17.599406  0.35
2024 Ramalingam N, Haass C, Dettmer U. Physiological roles of α-synuclein serine-129 phosphorylation - not an oxymoron. Trends in Neurosciences. 47: 480-490. PMID 38862330 DOI: 10.1016/j.tins.2024.05.005  0.83
2024 White AJ, Clark KA, Alexander KD, Ramalingam N, Young-Pearse TL, Dettmer U, Selkoe DJ, Ho GPH. A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons. Npj Parkinson's Disease. 10: 107. PMID 38773105 DOI: 10.1038/s41531-024-00725-y  0.795
2024 Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. Npj Parkinson's Disease. 10: 57. PMID 38472218 DOI: 10.1038/s41531-024-00675-5  0.707
2024 Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. Npj Parkinson's Disease. 10: 47. PMID 38424059 DOI: 10.1038/s41531-024-00662-w  0.723
2024 Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Zami A, Ostafe R, Dettmer U, Fortin JS. Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils. Bioorganic & Medicinal Chemistry. 100: 117613. PMID 38330847 DOI: 10.1016/j.bmc.2024.117613  0.795
2023 Ganegamage SK, Ramirez E, Alnakhala H, Tripathi A, Nguyen CCD, Zami A, Ostafe R, Tian S, Dettmer U, Fortin JS. 1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α-Synuclein Oligomer Formation . Acs Omega. 9: 1216-1229. PMID 38222653 DOI: 10.1021/acsomega.3c07453  0.792
2023 Shimanaka K, Shi B, Brontesi L, Alnakhala H, Jayanthi V, Subramanian K, Ramalingam N, Tripathi A, Dettmer U. Adding hydrophobicity or positive charges to the cytosolic half of the α-synuclein 3-11 helix increases membrane association and S129 phosphorylation. Febs Letters. PMID 37989349 DOI: 10.1002/1873-3468.14773  0.795
2023 Ramalingam N, Dettmer U. α-Synuclein serine129 phosphorylation - the physiology of pathology. Molecular Neurodegeneration. 18: 84. PMID 37953316 DOI: 10.1186/s13024-023-00680-x  0.752
2023 Ramalingam N, Brontesi L, Jin SX, Selkoe DJ, Dettmer U. Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models. Embo Reports. e57145. PMID 37870370 DOI: 10.15252/embr.202357145  0.821
2023 Wang T, Sun Y, Dettmer U. Astrocytes in Parkinson's Disease: From Role to Possible Intervention. Cells. 12. PMID 37830550 DOI: 10.3390/cells12192336  0.309
2023 Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, ... Dettmer U, et al. Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation. Acs Chemical Neuroscience. PMID 37818657 DOI: 10.1021/acschemneuro.3c00464  0.761
2023 Ramirez E, Min S, Ganegamage SK, Shimanaka K, Sosa MG, Dettmer U, Rochet JC, Fortin JS. Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation. Results in Chemistry. 5. PMID 37346091 DOI: 10.1016/j.rechem.2023.100938  0.732
2023 Ramirez E, Ganegamage SK, Elbatrawy AA, Alnakhala H, Shimanaka K, Tripathi A, Min S, Rochet JC, Dettmer U, Fortin JS. 5-Nitro-1,2-benzothiazol-3-amine and -Ethyl-1-[(ethylcarbamoyl)(5-nitro-1,2-benzothiazol-3-yl)amino]formamide Modulate α-Synuclein and Tau Aggregation. Acs Omega. 8: 20102-20115. PMID 37305264 DOI: 10.1021/acsomega.3c02668  0.782
2023 Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, ... ... Dettmer U, et al. Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. Npj Parkinson's Disease. 9: 4. PMID 36646701 DOI: 10.1038/s41531-023-00444-w  0.805
2023 Brontesi L, Imberdis T, Ramalingam N, Dettmer U. The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly. Journal of Neurochemistry. PMID 36625497 DOI: 10.1111/jnc.15763  0.75
2022 Fortin JS, Shimanaka K, Saraswati AP, Liu M, Wang KW, Hagar HT, Maity S, Ganegamage SK, Ellsworth E, Counts SE, Borhan B, Dettmer U, Kuo MH. Anti-fibrillization effects of sulfonamide derivatives on -synuclein and hyperphosphorylated tau isoform 1N4R. Journal of Molecular Structure. 1267. PMID 36310922 DOI: 10.1016/j.molstruc.2022.133574  0.675
2022 Fonseca-Ornelas L, Stricker JMS, Soriano-Cruz S, Weykopf B, Dettmer U, Muratore CR, Scherzer CR, Selkoe DJ. Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons. Npj Parkinson's Disease. 8: 118. PMID 36114228 DOI: 10.1038/s41531-022-00380-1  0.684
2022 Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, et al. Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 35792968 DOI: 10.1007/s13311-022-01268-x  0.596
2022 Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, et al. Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. Npj Parkinson's Disease. 8: 74. PMID 35680956 DOI: 10.1038/s41531-022-00335-6  0.494
2022 Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neve E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, et al. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 35445353 DOI: 10.1007/s13311-022-01199-7  0.684
2022 de Boni L, Watson AH, Zaccagnini L, Wallis A, Zhelcheska K, Kim N, Sanderson J, Jiang H, Martin E, Cantlon A, Rovere M, Liu L, Sylvester M, Lashley T, Dettmer U, et al. Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations. Acta Neuropathologica. PMID 35141810 DOI: 10.1007/s00401-022-02406-7  0.812
2022 Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Pathogenic mechanisms of cytosolic and membrane-enriched α-synuclein converge on fatty acid homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35086904 DOI: 10.1523/JNEUROSCI.1881-21.2022  0.779
2021 Tripathi A, Fanning S, Dettmer U. Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies? Biomolecules. 12. PMID 35053188 DOI: 10.3390/biom12010040  0.606
2021 Glajch KE, Moors TE, Chen Y, Bechade PA, Nam AY, Rajsombath MM, McCaffery TD, Dettmer U, Weihofen A, Hirst WD, Selkoe DJ, Nuber S. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34326260 DOI: 10.1073/pnas.2103425118  0.675
2021 Kim TE, Newman AJ, Imberdis T, Brontesi L, Tripathi A, Ramalingam N, Fanning S, Selkoe D, Dettmer U. Excess membrane binding of monomeric alpha-, beta-, and gamma-synuclein is invariably associated with inclusion formation and toxicity. Human Molecular Genetics. PMID 34254125 DOI: 10.1093/hmg/ddab188  0.823
2021 Ericsson M, von Saucken V, Newman A, Doehr L, Hoesch C, Kim TE, Dettmer U. Crowded Organelles, Lipid Accumulation, and Abnormal Membrane Tubulation in Cellular Models of Enhanced α-Synuclein Membrane Interaction. Brain Research. 147349. PMID 33571519 DOI: 10.1016/j.brainres.2021.147349  0.391
2021 Ramalingam N, Dettmer U. Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons. The Journal of Biological Chemistry. 296: 100271. PMID 33428933 DOI: 10.1016/j.jbc.2021.100271  0.76
2020 Ho GPH, Ramalingam N, Imberdis T, Wilkie EC, Dettmer U, Selkoe DJ. Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33103814 DOI: 10.1002/mds.28346  0.828
2020 Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, et al. A stearoyl-CoA desaturase inhibitor prevents multiple Parkinson's disease-phenotypes in α-synuclein mice. Annals of Neurology. PMID 32996158 DOI: 10.1002/ana.25920  0.696
2020 Terry-Kantor E, Tripathi A, Imberdis T, LaVoie ZM, Ho GPH, Selkoe D, Fanning S, Ramalingam N, Dettmer U. Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor. International Journal of Molecular Sciences. 21. PMID 32707907 DOI: 10.3390/ijms21155193  0.821
2020 Fanning S, Selkoe D, Dettmer U. Vesicle trafficking and lipid metabolism in synucleinopathy. Acta Neuropathologica. PMID 32607605 DOI: 10.1007/s00401-020-02177-z  0.673
2020 Kayed R, Dettmer U, Lesné SE. Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk. Journal of Parkinson's Disease. PMID 32508330 DOI: 10.3233/Jpd-201965  0.351
2020 Fanning S, Selkoe D, Dettmer U. Parkinson's disease: proteinopathy or lipidopathy? Npj Parkinson's Disease. 6: 3. PMID 31909184 DOI: 10.1038/s41531-019-0103-7  0.644
2019 Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase. Proceedings of the National Academy of Sciences of the United States of America. PMID 31548371 DOI: 10.1073/Pnas.1903216116  0.83
2019 Yeboah F, Kim TE, Bill A, Dettmer U. Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. Neurobiology of Disease. 104543. PMID 31351173 DOI: 10.1016/j.nbd.2019.104543  0.383
2019 Imberdis T, Fanning S, Newman A, Ramalingam N, Dettmer U. Studying α-Synuclein Conformation by Intact-Cell Cross-Linking. Methods in Molecular Biology (Clifton, N.J.). 1948: 77-91. PMID 30771172 DOI: 10.1007/978-1-4939-9124-2_8  0.756
2018 Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, ... ... Dettmer U, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Molecular Cell. PMID 30527540 DOI: 10.1016/J.Molcel.2018.11.028  0.819
2018 Dettmer U. Rationally Designed Variants of α-Synuclein Illuminate Its Structural Properties in Health and Disease. Frontiers in Neuroscience. 12: 623. PMID 30319334 DOI: 10.3389/fnins.2018.00623  0.403
2018 Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 100: 75-90.e5. PMID 30308173 DOI: 10.1016/j.neuron.2018.09.014  0.684
2017 Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Human Molecular Genetics. 26: 3466-3481. PMID 28911198 DOI: 10.1093/hmg/ddx227  0.813
2017 Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, et al. Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiology of Disease. PMID 28711409 DOI: 10.1016/J.Nbd.2017.07.007  0.432
2015 Dettmer U, Selkoe D, Bartels T. New insights into cellular α-synuclein homeostasis in health and disease. Current Opinion in Neurobiology. 36: 15-22. PMID 26282834 DOI: 10.1016/j.conb.2015.07.007  0.814
2015 Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nature Communications. 6: 8008. PMID 26224447 DOI: 10.1038/ncomms9008  0.801
2015 Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: 9596-601. PMID 26153422 DOI: 10.1073/pnas.1505953112  0.83
2015 Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nature Communications. 6: 7314. PMID 26076669 DOI: 10.1038/Ncomms8314  0.815
2015 Dettmer U, Bartels T. ExPLAining early synucleinopathies. Brain : a Journal of Neurology. 138: 1449-51. PMID 26013805 DOI: 10.1093/brain/awv099  0.652
2015 Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity. Biochemistry. 54: 279-92. PMID 25490121 DOI: 10.1021/bi501188a  0.749
2014 Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Defining the native state of α-synuclein Neurodegenerative Diseases. 13: 114-117. PMID 24192542 DOI: 10.1159/000355516  0.809
2013 Newman AJ, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous α-synuclein. Plos One. 8: e81314. PMID 24278419 DOI: 10.1371/journal.pone.0081314  0.623
2013 Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells. The Journal of Biological Chemistry. 288: 6371-85. PMID 23319586 DOI: 10.1074/jbc.M112.403311  0.789
2010 Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. The Journal of Biological Chemistry. 285: 26174-81. PMID 20538592 DOI: 10.1074/Jbc.M110.132548  0.553
2007 Haffner C, Dettmer U, Weiler T, Haass C. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. The Journal of Biological Chemistry. 282: 10632-8. PMID 17261586 DOI: 10.1074/Jbc.M611033200  0.563
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