Gilberto Spadoni - Publications

Affiliations: 
Biomolecular Sciences University of Urbino 
Area:
Organic and Medicinal Chemistry

109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ferlenghi F, Mari M, Gobbi G, Elisi GM, Mor M, Rivara S, Vacondio F, Bartolucci S, Bedini A, Fanini F, Spadoni G. N-(anilinoethyl)amide melatonergic ligands with improved water solubility and metabolic stability. Chemmedchem. PMID 34213063 DOI: 10.1002/cmdc.202100405  1
2021 Castelli R, Taranto S, Furiassi L, Bozza N, Marseglia G, Ferlenghi F, Rivara S, Retini M, Bedini A, Spadoni G, Matarazzo S, Ronca R, Presta M, Mor M, Giacomini A. Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma. European Journal of Medicinal Chemistry. 221: 113529. PMID 34004471 DOI: 10.1016/j.ejmech.2021.113529  0.76
2020 Pala D, Scalvini L, Elisi GM, Lodola A, Mor M, Spadoni G, Ferrara FF, Pavoni E, Roscilli G, Milazzo FM, Battistuzzi G, Rivara S, Giannini G. New classes of potent heparanase inhibitors from ligand-based virtual screening. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1685-1696. PMID 32907434 DOI: 10.1080/14756366.2020.1811701  0.72
2020 Elisi GM, Bedini A, Scalvini L, Carmi C, Bartolucci S, Lucini V, Scaglione F, Mor M, Rivara S, Spadoni G. Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria. Molecules (Basel, Switzerland). 25. PMID 32899888 DOI: 10.3390/Molecules25184057  0.76
2020 Piomelli D, Scalvini L, Fotio Y, Lodola A, Spadoni G, Tarzia G, Mor M. N-acylethanolamine Acid Amidase (NAAA): Structure, Functions and Inhibition. Journal of Medicinal Chemistry. PMID 32191459 DOI: 10.1021/Acs.Jmedchem.0C00191  0.76
2020 Carnevali L, Statello R, Vacondio F, Ferlenghi F, Spadoni G, Rivara S, Mor M, Sgoifo A. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 31948828 DOI: 10.1016/J.Euroneuro.2019.12.119  0.72
2019 Sartini S, Levati E, Maccesi M, Guerra M, Spadoni G, Bach S, Benincasa M, Scocchi M, Ottonello S, Rivara S, Montanini B. New antimicrobials targeting bacterial RNA polymerase holoenzyme assembly identified with an BRET-based discovery platform. Acs Chemical Biology. PMID 31310497 DOI: 10.1021/Acschembio.9B00178  0.72
2019 López-Canul M, Min SH, Posa L, De Gregorio D, Bedini A, Spadoni G, Gobbi G, Comai S. Melatonin MT and MT Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle. International Journal of Molecular Sciences. 20. PMID 31108968 DOI: 10.3390/Ijms20102452  0.76
2018 Bedini A, Fraternale A, Crinelli R, Mari M, Bartolucci S, Chiarantini L, Spadoni G. Design, synthesis and biological activity of hydrogen peroxide responsive arylboronate melatonin hybrids. Chemical Research in Toxicology. PMID 30560658 DOI: 10.1021/Acs.Chemrestox.8B00216  1
2018 Spadoni G, Bedini A, Furiassi L, Mari M, Mor M, Scalvini L, Lodola A, Ghidini A, Lucini V, Dugnani S, Scaglione F, Piomelli D, Jung KM, Supuran CT, Lucarini L, et al. Identification of bivalent ligands with melatonin receptor agonist and fatty acid amide hydrolase (FAAH) inhibitory activity that exhibit ocular hypotensive effect in the rabbit. Journal of Medicinal Chemistry. PMID 30126274 DOI: 10.1021/Acs.Jmedchem.8B00893  1
2018 Rivara S, Scalvini L, Lodola A, Mor M, Caignard DH, Delagrange P, Collina S, Lucini V, Scaglione F, Furiassi L, Mari M, Lucarini S, Bedini A, Spadoni G. Tetrahydroquinoline ring as a versatile bioisostere of tetralin for melatonin receptor ligands. Journal of Medicinal Chemistry. PMID 29595267 DOI: 10.1021/Acs.Jmedchem.8B00359  1
2017 Gatti G, Lucini V, Dugnani S, Calastretti A, Spadoni G, Bedini A, Rivara S, Mor M, Canti G, Scaglione F, Bevilacqua A. Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells. Oncotarget. 8: 68338-68353. PMID 28978121 DOI: 10.18632/Oncotarget.20124  0.76
2016 Gobbi G, Lopez-Canul M, Palazzo E, Dominguez-Lopez S, Luongo L, Lacoste B, Comai S, Angeloni D, Fraschini F, Spadoni G, Bedini A, Tarzia G, Maione S, Granados-Soto V. PT628. First in class melatonin MT2 receptors agonists for neuropathic pain The International Journal of Neuropsychopharmacology. 19: 30-30. DOI: 10.1093/Ijnp/Pyw044.628  0.76
2015 Carnevali L, Vacondio F, Rossi S, Macchi E, Spadoni G, Bedini A, Neumann ID, Rivara S, Mor M, Sgoifo A. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Scientific Reports. 5: 18218. PMID 26656183 DOI: 10.1038/Srep18218  1
2015 Carnevali L, Vacondio F, Rossi S, Callegari S, Macchi E, Spadoni G, Bedini A, Rivara S, Mor M, Sgoifo A. Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 26391492 DOI: 10.1016/J.Autneu.2015.07.057  1
2015 Spadoni G, Bedini A, Lucarini S, Mari M, Caignard DH, Boutin JA, Delagrange P, Lucini V, Scaglione F, Lodola A, Zanardi F, Pala D, Mor M, Rivara S. Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines. Journal of Medicinal Chemistry. 58: 7512-25. PMID 26334942 DOI: 10.1021/Acs.Jmedchem.5B01066  1
2015 Spadoni G, Bedini A, Lucarini S, Mor M, Rivara S. Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy. Expert Opinion On Drug Metabolism & Toxicology. 11: 1145-56. PMID 25956235 DOI: 10.1517/17425255.2015.1045487  1
2015 Bartolucci S, Mari M, Bedini A, Piersanti G, Spadoni G. Iridium-catalyzed direct synthesis of tryptamine derivatives from indoles: exploiting n-protected β-amino alcohols as alkylating agents. The Journal of Organic Chemistry. 80: 3217-22. PMID 25699684 DOI: 10.1021/Acs.Joc.5B00195  1
2015 Lopez-Canul M, Palazzo E, Dominguez-Lopez S, Luongo L, Lacoste B, Comai S, Angeloni D, Fraschini F, Boccella S, Spadoni G, Bedini A, Tarzia G, Maione S, Granados-Soto V, Gobbi G. Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain. 156: 305-17. PMID 25599452 DOI: 10.1097/01.J.Pain.0000460311.71572.5F  1
2015 Rivara S, Pala D, Bedini A, Spadoni G. Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012 - 2014). Expert Opinion On Therapeutic Patents. 25: 425-41. PMID 25579320 DOI: 10.1517/13543776.2014.1001739  0.76
2015 Spadoni G, Bedini A, Lucarini S, Mor M, Rivara S. Pharmacokinetic and pharmacodynamic evaluation of ramelteon: An insomnia therapy Expert Opinion On Drug Metabolism and Toxicology. 11: 1145-1156. DOI: 10.1517/17425255.2015.1045487  1
2015 Rivara S, Pala D, Bedini A, Spadoni G. Therapeutic uses of melatonin and melatonin derivatives: A patent review (2012 - 2014) Expert Opinion On Therapeutic Patents. 25: 425-441. DOI: 10.1517/13543776.2014.1001739  1
2014 Mari M, Lucarini S, Bartoccini F, Piersanti G, Spadoni G. Synthesis of 2-substituted tryptophans via a C3- to C2-alkyl migration. Beilstein Journal of Organic Chemistry. 10: 1991-8. PMID 25246958 DOI: 10.3762/Bjoc.10.207  1
2014 Pala D, Scalvini L, Lodola A, Mor M, Flammini L, Barocelli E, Lucini V, Scaglione F, Bartolucci S, Bedini A, Rivara S, Spadoni G. Synthesis and characterization of new bivalent agents as melatonin- and Histamine H3-ligands International Journal of Molecular Sciences. 15: 16114-16133. PMID 25222552 DOI: 10.3390/Ijms150916114  1
2014 Spadoni G, Bedini A, Bartolucci S, Pala D, Mor M, Riccioni T, Borsini F, Cabri W, Celona D, Marzi M, Tarzia G, Rivara S, Minetti P. Towards the development of 5-HT₇ ligands combining serotonin-like and arylpiperazine moieties. European Journal of Medicinal Chemistry. 80: 8-35. PMID 24763360 DOI: 10.1016/J.Ejmech.2014.04.034  1
2014 Ochoa-Sanchez R, Comai S, Spadoni G, Bedini A, Tarzia G, Gobbi G. Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states. Neuroscience Letters. 561: 156-61. PMID 24406151 DOI: 10.1016/J.Neulet.2013.12.069  1
2014 Mari M, Tassoni A, Lucarini S, Fanelli M, Piersanti G, Spadoni G. Brønsted acid catalyzed bisindolization of α-amido acetals: Synthesis and anticancer activity of bis(indolyl)ethanamino derivatives European Journal of Organic Chemistry. 2014: 3822-3830. DOI: 10.1002/Ejoc.201402055  1
2013 Pala D, Lodola A, Bedini A, Spadoni G, Rivara S. Homology models of melatonin receptors: challenges and recent advances. International Journal of Molecular Sciences. 14: 8093-121. PMID 23584026 DOI: 10.3390/Ijms14048093  0.76
2013 Pala D, Lodola A, Bedini A, Spadoni G, Rivara S. Homology models of melatonin receptors: Challenges and recent advances International Journal of Molecular Sciences. 14: 8093-8121. DOI: 10.3390/ijms14048093  1
2013 Lucarini S, Mari M, Piersanti G, Spadoni G. Organocatalyzed coupling of indoles with dehydroalanine esters: Synthesis of bis(indolyl)propanoates and indolacrylates Rsc Advances. 3: 19135-19143. DOI: 10.1039/C3Ra42922A  1
2012 Rivara S, Pala D, Lodola A, Mor M, Lucini V, Dugnani S, Scaglione F, Bedini A, Lucarini S, Tarzia G, Spadoni G. MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides. Chemmedchem. 7: 1954-64. PMID 22927210 DOI: 10.1002/Cmdc.201200303  1
2012 Ochoa-Sanchez R, Rainer Q, Comai S, Spadoni G, Bedini A, Rivara S, Fraschini F, Mor M, Tarzia G, Gobbi G. Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 39: 318-25. PMID 22789661 DOI: 10.1016/J.Pnpbp.2012.07.003  1
2012 Righi M, Topi F, Bartolucci S, Bedini A, Piersanti G, Spadoni G. Synthesis of tryptamine derivatives via a direct, one-pot reductive alkylation of indoles. The Journal of Organic Chemistry. 77: 6351-7. PMID 22724919 DOI: 10.1021/Jo3010028  1
2012 Lucarini S, Bartolucci S, Bedini A, Gatti G, Orlando P, Piersanti G, Spadoni G. Synthesis and configuration determination of all enantiopure stereoisomers of the melatonin receptor ligand 4-phenyl-2-propionamidotetralin using an expedient optical resolution of 4-phenyl-2-tetralone. Organic & Biomolecular Chemistry. 10: 305-13. PMID 22095411 DOI: 10.1039/C1Ob06369C  1
2012 Devavry S, Legros C, Brasseur C, Delagrange P, Spadoni G, Cohen W, Malpaux B, Boutin JA, Nosjean O. Description of the constitutive activity of cloned human melatonin receptors hMT(1) and hMT(2) and discovery of inverse agonists. Journal of Pineal Research. 53: 29-37. PMID 22017484 DOI: 10.1111/J.1600-079X.2011.00968.X  1
2011 Ochoa-Sanchez R, Comai S, Lacoste B, Bambico FR, Dominguez-Lopez S, Spadoni G, Rivara S, Bedini A, Angeloni D, Fraschini F, Mor M, Tarzia G, Descarries L, Gobbi G. Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 18439-52. PMID 22171046 DOI: 10.1523/Jneurosci.2676-11.2011  1
2011 Bedini A, Lucarini S, Spadoni G, Tarzia G, Scaglione F, Dugnani S, Pannacci M, Lucini V, Carmi C, Pala D, Rivara S, Mor M. Toward the definition of stereochemical requirements for MT2-selective antagonists and partial agonists by studying 4-phenyl-2-propionamidotetralin derivatives. Journal of Medicinal Chemistry. 54: 8362-72. PMID 22047556 DOI: 10.1021/Jm200790V  1
2011 Spadoni G, Bedini A, Orlando P, Lucarini S, Tarzia G, Mor M, Rivara S, Lucini V, Pannacci M, Scaglione F. Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors. Bioorganic & Medicinal Chemistry. 19: 4910-6. PMID 21775151 DOI: 10.1016/J.Bmc.2011.06.063  1
2011 Spadoni G, Bedini A, Rivara S, Mor M. Melatonin receptor agonists: New options for insomnia and depression treatment Cns Neuroscience and Therapeutics. 17: 733-741. PMID 21554566 DOI: 10.1111/J.1755-5949.2010.00197.X  1
2011 Riccioni T, Bordi F, Minetti P, Spadoni G, Yun HM, Im BH, Tarzia G, Rhim H, Borsini F. ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors. European Journal of Pharmacology. 661: 8-14. PMID 21549693 DOI: 10.1016/J.Ejphar.2011.04.028  1
2011 Righi M, Bedini A, Piersanti G, Romagnoli F, Spadoni G. Direct, one-pot reductive alkylation of anilines with functionalized acetals mediated by triethylsilane and TFA. Straightforward route for unsymmetrically substituted ethylenediamine. The Journal of Organic Chemistry. 76: 704-7. PMID 21175194 DOI: 10.1021/Jo102109F  1
2010 Lucarini S, Bartoccini F, Battistoni F, Diamantini G, Piersanti G, Righi M, Spadoni G. A novel one-pot approach of hexahydropyrrolo[2,3-b]indole nucleus by a cascade addition/cyclization strategy: synthesis of (+/-)-esermethole. Organic Letters. 12: 3844-7. PMID 20795744 DOI: 10.1021/Ol101527J  1
2010 Mor M, Rivara S, Pala D, Bedini A, Spadoni G, Tarzia G. Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists. Expert Opinion On Therapeutic Patents. 20: 1059-77. PMID 20533893 DOI: 10.1517/13543776.2010.496455  1
2010 Lucarini S, Alessi M, Bedini A, Giorgini G, Piersanti G, Spadoni G. Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives. Chemistry, An Asian Journal. 5: 550-4. PMID 20108301 DOI: 10.1002/Asia.200900441  1
2009 Rivara S, Vacondio F, Fioni A, Silva C, Carmi C, Mor M, Lucini V, Pannacci M, Caronno A, Scaglione F, Gobbi G, Spadoni G, Bedini A, Orlando P, Lucarini S, et al. N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. Chemmedchem. 4: 1746-55. PMID 19728346 DOI: 10.1002/Cmdc.200900240  1
2009 LoVerme J, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Stella N, Xu C, Tarzia G, Piomelli D. Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorganic & Medicinal Chemistry Letters. 19: 639-43. PMID 19128970 DOI: 10.1016/J.Bmcl.2008.12.059  1
2009 Antonioni G, Bonvicini S, Spadoni G, Cozzani V. Development of a framework for the risk assessment of Na-Tech accidental events Reliability Engineering and System Safety. 94: 1442-1450. DOI: 10.1016/j.ress.2009.02.026  0.01
2008 Rivara S, Mor M, Bedini A, Spadoni G, Tarzia G. Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Current Topics in Medicinal Chemistry. 8: 954-68. PMID 18673165 DOI: 10.2174/156802608784936719  1
2008 Lucarini S, Bedini A, Spadoni G, Piersanti G. An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT(2) melatonin receptor antagonist. Organic & Biomolecular Chemistry. 6: 147-50. PMID 18075659 DOI: 10.1039/B713904G  1
2007 Rivara S, Lodola A, Mor M, Bedini A, Spadoni G, Lucini V, Pannacci M, Fraschini F, Scaglione F, Sanchez RO, Gobbi G, Tarzia G. N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands. Journal of Medicinal Chemistry. 50: 6618-26. PMID 18052314 DOI: 10.1021/Jm700957J  1
2007 Spadoni G, Bedini A, Diamantini G, Tarzia G, Rivara S, Lorenzi S, Lodola A, Mor M, Lucini V, Pannacci M, Caronno A, Fraschini F. Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists. Chemmedchem. 2: 1741-9. PMID 17907131 DOI: 10.1002/Cmdc.200700141  1
2007 Radogna F, Paternoster L, Albertini MC, Cerella C, Accorsi A, Bucchini A, Spadoni G, Diamantini G, Tarzia G, De Nicola M, D'Alessio M, Ghibelli L. Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cells. Journal of Pineal Research. 43: 154-62. PMID 17645693 DOI: 10.1111/J.1600-079X.2007.00455.X  1
2007 Di Giacomo B, Bedini A, Spadoni G, Tarzia G, Fraschini F, Pannacci M, Lucini V. Synthesis and biological activity of new melatonin dimeric derivatives. Bioorganic & Medicinal Chemistry. 15: 4643-50. PMID 17481904 DOI: 10.1016/J.Bmc.2007.03.080  1
2006 Bedini A, Spadoni G, Gatti G, Lucarini S, Tarzia G, Rivara S, Lorenzi S, Lodola A, Mor M, Lucini V, Pannacci M, Scaglione F. Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands. Journal of Medicinal Chemistry. 49: 7393-403. PMID 17149869 DOI: 10.1021/Jm060850A  1
2006 Spadoni G, Bedini A, Guidi T, Tarzia G, Lucini V, Pannacci M, Fraschini F. Towards the development of mixed MT(1)-agonist/MT(2)-antagonist melatonin receptor ligands. Chemmedchem. 1: 1099-105. PMID 16955531 DOI: 10.1002/Cmdc.200600133  1
2006 Spadoni G, Diamantini G, Bedini A, Tarzia G, Vacondio F, Silva C, Rivara M, Mor M, Plazzi PV, Zusso M, Franceschini D, Giusti P. Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity. Journal of Pineal Research. 40: 259-69. PMID 16499563 DOI: 10.1111/J.1600-079X.2005.00309.X  1
2006 Rivara S, Diamantini G, Di Giacomo B, Lamba D, Gatti G, Lucini V, Pannacci M, Mor M, Spadoni G, Tarzia G. Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue. Bioorganic & Medicinal Chemistry. 14: 3383-91. PMID 16431121 DOI: 10.1016/J.Bmc.2005.12.053  1
2006 Rivara S, Mor M, Lorenzi S, Lodola A, Plazzi PV, Spadoni G, Bedini A, Tarzia G. MT2 selective melatonin receptor antagonists: Design and structure-activity relationships Arkivoc. 2006: 8-16. DOI: 10.3998/Ark.5550190.0007.802  1
2005 Mor M, Rivara S, Lodola A, Lorenzi S, Bordi F, Plazzi PV, Spadoni G, Bedini A, Duranti A, Tontini A, Tarzia G. Application of 3D-QSAR in the rational design of receptor ligands and enzyme inhibitors. Chemistry & Biodiversity. 2: 1438-51. PMID 17191945 DOI: 10.1002/Cbdv.200590117  1
2005 Cozzani V, Gubinelli G, Antonioni G, Spadoni G, Zanelli S. The assessment of risk caused by domino effect in quantitative area risk analysis Journal of Hazardous Materials. 127: 14-30. PMID 16102897 DOI: 10.1016/j.jhazmat.2005.07.003  0.01
2005 Rivara S, Lorenzi S, Mor M, Plazzi PV, Spadoni G, Bedini A, Tarzia G. Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models. Journal of Medicinal Chemistry. 48: 4049-60. PMID 15943478 DOI: 10.1021/Jm048956Y  1
2005 Bedini A, Di Giacomo B, Gatti G, Spadoni G. Synthesis and conformational study of 3,4-carbocyclic bridged indole melatonin and serotonin analogues Bioorganic and Medicinal Chemistry. 13: 4651-4657. PMID 15916895 DOI: 10.1016/J.Bmc.2005.04.064  1
2004 Lucini V, Pannacci M, Scaglione F, Fraschini F, Rivara S, Mor M, Bordi F, Plazzi PV, Spadoni G, Bedini A, Piersanti G, Diamantini G, Tarzia G. Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity. Journal of Medicinal Chemistry. 47: 4202-12. PMID 15293992 DOI: 10.1021/Jm040768K  1
2004 Mor M, Silva C, Vacondio F, Plazzi PV, Bertoni S, Spadoni G, Diamantini G, Bedini A, Tarzia G, Zusso M, Franceschini D, Giusti P. Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities. Journal of Pineal Research. 36: 95-102. PMID 14962060 DOI: 10.1046/J.1600-079X.2003.00102.X  1
2003 Spadoni G, Bedini A, Piersanti G, Mor M, Rivara S, Tarzia G. Strategies leading to MT2 selective melatonin receptor antagonists. Advances in Experimental Medicine and Biology. 527: 577-85. PMID 15206776 DOI: 10.1007/978-1-4615-0135-0_66  1
2003 Mor M, Spadoni G, Diamantini G, Bedini A, Tarzia G, Silva C, Vacondio F, Rivara M, Plazzi PV, Franceschini D, Zusso M, Giusti P. Antioxidant and cytoprotective activity of indole derivatives related to melatonin. Advances in Experimental Medicine and Biology. 527: 567-75. PMID 15206775 DOI: 10.1007/978-1-4615-0135-0_65  1
2003 Naguib M, Baker MT, Spadoni G, Gregerson M. The hypnotic and analgesic effects of 2-bromomelatonin. Anesthesia and Analgesia. 97: 763-8. PMID 12933398 DOI: 10.1213/01.Ane.0000074796.10856.1F  1
2003 Tarzia G, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Vincenzo Plazzi P, Kathuria S, Piomelli D. Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists. Bioorganic & Medicinal Chemistry. 11: 3965-73. PMID 12927857 DOI: 10.1016/S0968-0896(03)00413-9  1
2003 Gatti G, Piersanti G, Spadoni G. Conformation by NMR of two tetralin-based receptor ligands. Farmaco (Società Chimica Italiana : 1989). 58: 469-76. PMID 12818685 DOI: 10.1016/S0014-827X(03)00064-8  1
2003 Rivara S, Mor M, Silva C, Zuliani V, Vacondio F, Spadoni G, Bedini A, Tarzia G, Lucini V, Pannacci M, Fraschini F, Plazzi PV. Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation. Journal of Medicinal Chemistry. 46: 1429-39. PMID 12672242 DOI: 10.1021/Jm020982D  1
2002 Winczyk K, Pawlikowski M, Lawnicka H, Kunert-Radek J, Spadoni G, Tarzia G, Karasek M. Effects of melatonin and melatonin receptors ligand N-[(4-methoxy-1H-indol-2-yl)methyl]propanamide on murine Colon 38 cancer growth in vitro and in vivo. Neuro Endocrinology Letters. 23: 50-4. PMID 12019352  1
2001 Spadoni G, Balsamini C, Diamantini G, Tontini A, Tarzia G, Mor M, Rivara S, Plazzi PV, Nonno R, Lucini V, Pannacci M, Fraschini F, Stankov BM. 2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists. Journal of Medicinal Chemistry. 44: 2900-12. PMID 11520198 DOI: 10.1021/Jm001125H  1
2001 Mor M, Spadoni G, Di Giacomo B, Diamantini G, Bedini A, Tarzia G, Plazzi PV, Rivara S, Nonno R, Lucini V, Pannacci M, Fraschini F, Stankov BM. Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands. Bioorganic & Medicinal Chemistry. 9: 1045-57. PMID 11354661 DOI: 10.1016/S0968-0896(00)00322-9  1
2000 Nonno R, Lucini V, Spadoni G, Pannacci M, Croce A, Esposti D, Balsamini C, Tarzia G, Fraschini F, Stankov BM. A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties. Journal of Pineal Research. 29: 234-40. PMID 11068946 DOI: 10.1034/J.1600-0633.2002.290406.X  1
2000 Tarzia G, Diamantini G, Mor M, Spadoni G. Design and synthesis of melatonin receptors agonists and antagonists. Farmaco (Società Chimica Italiana : 1989). 55: 184-7. PMID 10919077 DOI: 10.1016/S0014-827X(00)00017-3  1
1999 Balsamini C, Bedini A, Diamantini G, Spadoni G, Tarzia G, Tontini A, Di Fabio R, Donati D. 3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification. Farmaco (Società Chimica Italiana : 1989). 54: 101-11. PMID 10321036 DOI: 10.1016/S0014-827X(98)00110-4  1
1999 Mor M, Plazzi PV, Spadoni G, Tarzia G. Melatonin. Current Medicinal Chemistry. 6: 501-18. PMID 10213796  1
1999 Tarzia G, Diamantini G, Spadoni G. Indole melatonin agonists and antagonists derived by shifting the melatonin side chain from the C-3 to the N-1 or to the C-2 indole position. Biological Signals and Receptors. 8: 24-31. PMID 10085459 DOI: 10.1159/000014565  1
1999 Spadoni G, Mor M, Tarzia G. Structure-affinity relationships of indole-based melatonin analogs. Biological Signals and Receptors. 8: 15-23. PMID 10085458 DOI: 10.1159/000014564  1
1998 Mor M, Rivara S, Silva C, Bordi F, Plazzi PV, Spadoni G, Diamantini G, Balsamini C, Tarzia G, Fraschini F, Lucini V, Nonno R, Stankov BM. Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. Journal of Medicinal Chemistry. 41: 3831-44. PMID 9748358 DOI: 10.1021/Jm9810093  1
1998 Spadoni G, Balsamini C, Bedini A, Diamantini G, Di Giacomo B, Tontini A, Tarzia G, Mor M, Plazzi PV, Rivara S, Nonno R, Pannacci M, Lucini V, Fraschini F, Stankov BM. 2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists. Journal of Medicinal Chemistry. 41: 3624-34. PMID 9733487 DOI: 10.1021/Jm970721H  1
1998 Balsamini C, Bedini A, Spadoni G, Tarzia G, Tontini A, Balduini W, Cimino M. 1-Aminocylopropane-1-carboxylic acid derivatives as ligands at the glycine-binding site of the N-methyl-D-aspartate receptor. Farmaco (Società Chimica Italiana : 1989). 53: 181-8. PMID 9639866 DOI: 10.1016/S0014-827X(98)00005-6  1
1998 Balsamini C, Bedini A, Diamantini G, Spadoni G, Tontini A, Tarzia G, Di Fabio R, Feriani A, Reggiani A, Tedesco G, Valigi R. (E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists. Journal of Medicinal Chemistry. 41: 808-20. PMID 9526557 DOI: 10.1021/Jm970416W  0.8
1998 Diamantini G, Tarzia G, Spadoni G, D'Alpaos M, Traldi P. Metastable ion studies in the characterization of melatonin isomers Rapid Communications in Mass Spectrometry. 12: 1538-1542. DOI: 10.1002/(Sici)1097-0231(19981030)12:20<1538::Aid-Rcm342>3.0.Co;2-I  1
1998 Spadoni G, Balsamini C, Bedini A, Carey A, Diamantini G, Di Giacomo B, Tontini A, Tarzia G, Nonno R, Lucini V, Pannacci M, Michaylov Stankov B, Fraschini F. N-acyl-5- and -2,5-substituted tryptamines: Synthesis, activity and affinity for human mt1 and mt2 melatonin receptors Medicinal Chemistry Research. 8: 487-498.  1
1997 Tarzia G, Diamantini G, Di Giacomo B, Spadoni G, Esposti D, Nonno R, Lucini V, Pannacci M, Fraschini F, Stankov BM. 1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: a new class of potent indole melatonin analogues. Journal of Medicinal Chemistry. 40: 2003-10. PMID 9207941 DOI: 10.1021/Jm960653J  1
1997 Spadoni G, Balsamini C, Diamantini G, Di Giacomo B, Tarzia G, Mor M, Plazzi PV, Rivara S, Lucini V, Nonno R, Pannacci M, Fraschini F, Stankov BM. Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study. Journal of Medicinal Chemistry. 40: 1990-2002. PMID 9207940 DOI: 10.1021/Jm960651Z  1
1996 Gaviraghi G, Perboni A, Tamburini B, Xerri L, Salvatori A, Spadoni G, Tarzia G. Synthesis and antimicrobial evaluation of 2 beta-chloromethyl-6 beta-carbamoylmethyl-penam-1,1-dioxide-3-carboxylic acid. Farmaco (Società Chimica Italiana : 1989). 51: 535-8. PMID 8765676  1
1995 Balsamini C, Diamantini G, Duranti A, Spadoni G, Tontini A. A new synthesis of 2-substituted DL-tryptophan derivatives Synthesis. 370-372. DOI: 10.1055/S-1995-3915  1
1994 Balsamini C, Bedini A, Spadoni G, Burdisso M, Maria Capelli A. Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives Tetrahedron. 50: 3773-3784. DOI: 10.1016/S0040-4020(01)90397-7  1
1994 Balsamini C, Bedini A, Galarini R, Spadoni G, Tarzia G, Hamdan M. Reactions of 3-carbomethoxy-2-aza-1,3-butadiene derivatives with dienophiles Tetrahedron. 50: 12375-12394. DOI: 10.1016/S0040-4020(01)89546-6  1
1993 Spadoni G, Stankov B, Duranti A, Biella G, Lucini V, Salvatori A, Fraschini F. 2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. Journal of Medicinal Chemistry. 36: 4069-74. PMID 8258829 DOI: 10.1021/Jm00077A010  1
1993 Spadoni G, Balsamini C, Bedini A, Mugnaini M. 1-Aminocyclopropane-1-carboxylic acid derivatives: a new, general synthesis and NMDA receptor complex binding affinity study. Farmaco (Società Chimica Italiana : 1989). 48: 1663-74. PMID 8135990  1
1993 Hamdan M, Curcuruto O, Tarzia G, Balsamini C, Bedini A, Spadoni G. Differentiation between isomeric 1-aminocyclo-propane- 1 - carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation International Journal of Mass Spectrometry and Ion Processes. 124: 205-213. DOI: 10.1016/0168-1176(93)80091-R  1
1992 Duranti E, Stankov B, Spadoni G, Duranti A, Lucini V, Capsoni S, Biella G, Fraschini F. 2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist Life Sciences. 51: 479-485. PMID 1322481 DOI: 10.1016/0024-3205(92)90024-J  1
1992 Balsamini C, Spadoni G, Bedini A, Tarzia G, Lanfranchi M, Pellinghelli MA. 4,5‐Dihydroisoxazole and 4,5‐dihydro‐1,2,4‐oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N‐(diphenylmethylene)‐α,β‐dehydroamino acids Journal of Heterocyclic Chemistry. 29: 1593-1598. DOI: 10.1002/Jhet.5570290637  0.8
1992 Spadoni G, Balsamini C, Bedini A, Duranti E, Tontini A. Short synthesis of tryptophane and β-carboline derivatives by reaction of indoles with N-(diphenylmethylene)-α,β-didehydroamino acid esters Journal of Heterocyclic Chemistry. 29: 305-309. DOI: 10.1002/Jhet.5570290205  1
1992 Balsamini C, Spadoni G, Redini A, Tarzia G, Lanfranchi M, Pellinghelli MA. 4,5-dihydroisoxazole and 4,5-dihydro-1,2,4-oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N-(diphenylmethylene)-α,β-dehydroamino acids Mathematical Problems in Engineering. 29: 1593-1598.  1
1991 Balsamini C, Tarzia G, Spadoni G, Salvatori A, Staccioli L. N-(Diphenylmethylene)-α,β-didehydroamino acid esters. Thermal and lewis acid induced dimerizations Organic Preparations and Procedures International. 23: 122-125. DOI: 10.1080/00304949109458294  1
1990 Diamantini G, Spadoni G, Salvatori G, Duranti E. 7-Substituted theophyllines. Part VI - N-[2-(4-chlorophenoxyl)-1-phenyl-alkyl]-alkylamido derivatives Farmaco. 45: 665-672. PMID 2271074  1
1990 Sestili P, Spadoni G, Balsamini C, Scovassi I, Cattabeni F, Duranti E, Cantoni O, Higgins D, Thomson C. Structural requirements for inhibitors of poly(ADP-ribose) Polymerase Journal of Cancer Research and Clinical Oncology. 116: 615-622. PMID 2123880 DOI: 10.1007/Bf01637083  1
1990 Balsamini C, Duranti E, Salvatori A, Spadoni G, Barone D. Methyl N-(diphenylmethyl)-D,L-tryptophanates: Synthesis and benzodiazepine receptor affinity Farmaco. 45: 1111-1117. PMID 1965622  1
1990 Balsamini C, Duranti E, Mariani L, Salvatori A, Spadoni G. Stereospecific synthesis of N-(Diphenylmethylene) -α,β-didehydroamino acid methyl esters from β-hydroxy- α-amino acids Synthesis. 779-781. DOI: 10.1055/S-1990-27012  1
1989 Balsamini C, Spadoni G, Duranti E, Cerrini S, Lamba D, Fedeli W. N-benzhydryl-tryptamines and 1,1-diphenyl-tetrahydro-β-carbolines: Synthesis, x-ray crystal structure and benzodiazepine receptor affinity Farmaco. 44: 399-413. PMID 2550017  1
1989 Sestili P, Balsamini C, Spadoni G, Duranti E, Cattabeni F, Higgins D, Thomson C, Cantoni O. Substituted benzamides as poly (ADP-ribose) transferase inhibitors: Development of new derivatives by using computer graphics techniques Pharmacological Research. 21: 123-124. PMID 2517338 DOI: 10.1016/S1043-6618(89)80082-9  1
1988 Sestili P, Balsmini C, Spadoni G, Cattabeni F, Cantoni O. Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: A study on structure activity relationships Pharmacological Research Communications. 20: 613-614. PMID 3140253 DOI: 10.1016/S0031-6989(88)80091-2  1
1988 Duranti E, Balsamini C, Spadoni G, Staccioli L. Reaction of secondary acetylenic bromides with sodium nitrite: Synthesis of 3,5-alkyl(aryl)-4-nitroisoxazoles Journal of Organic Chemistry. 53: 2870-2872. DOI: 10.1021/Jo00247A048  1
1987 Diamantini G, Spadoni G, Duranti E, Niada R. 7-substituted theophyllines Part V - Azabenzhydrylaminoalkyl derivatives Farmaco, Edizione Scientifica. 42: 561-566. PMID 3666126  1
1987 Cantoni O, Sestili P, Spadoni G, Balsamini C, Cucchiarini L, Cattabeni F. Analogues of benzamide containing a sulfur atom as poly(ADP-ribose)transferase inhibitors Biochemistry International. 15: 329-337. PMID 3124848  1
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