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Katherine Henzler-Wildman, Ph.D. - Publications

Affiliations: 
Biochemistry University of Wisconsin, Madison, Madison, WI 
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wegrzynowicz AK, Heelan WJ, Demas SP, McLean MS, Peters JM, Henzler-Wildman KA. Substrate dependence of transport coupling and phenotype of a small multidrug resistance transporter in . Journal of Bacteriology. e0015124. PMID 39258918 DOI: 10.1128/jb.00151-24  0.411
2024 Spreacker PJ, Wegrzynowicz AK, Porter CJ, Beeninga WF, Demas S, Powers EN, Henzler-Wildman KA. Functional promiscuity of small multidrug resistance transporters from Staphylococcus aureus, Pseudomonas aeruginosa, and Francisella tularensis. Molecular Microbiology. PMID 38284496 DOI: 10.1111/mmi.15231  0.409
2023 Wegrzynowicz AK, Heelan WJ, Demas SP, McLean MS, Peters JM, Henzler-Wildman KA. A Small Multidrug Resistance Transporter in Confers Substrate-Specific Resistance or Susceptibility. Biorxiv : the Preprint Server For Biology. PMID 37808795 DOI: 10.1101/2023.09.28.560013  0.329
2023 Shcherbakov AA, Brousseau M, Henzler-Wildman KA, Hong M. Microsecond Motion of the Bacterial Transporter EmrE in Lipid Bilayers. Journal of the American Chemical Society. 145: 10104-10115. PMID 37097985 DOI: 10.1021/jacs.3c00340  0.439
2022 Spreacker PJ, Brousseau M, Hisao GS, Soltani M, Davis JH, Henzler-Wildman KA. Charge neutralization of the active site glutamates does not limit substrate binding and transport by small multidrug resistance transporter EmrE. The Journal of Biological Chemistry. 299: 102805. PMID 36529287 DOI: 10.1016/j.jbc.2022.102805  0.8
2022 Spreacker PJ, Thomas NE, Beeninga WF, Brousseau M, Porter CJ, Hibbs KM, Henzler-Wildman KA. Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility. Nature Communications. 13: 7655. PMID 36496486 DOI: 10.1038/s41467-022-35410-2  0.753
2022 Shcherbakov AA, Spreacker PJ, Dregni AJ, Henzler-Wildman KA, Hong M. High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport. Nature Communications. 13: 991. PMID 35181664 DOI: 10.1038/s41467-022-28556-6  0.782
2021 Thomas NE, Feng W, Henzler-Wildman KA. A Solid Supported Membrane Electrophysiology Assay for Efficient Characterization of Ion-Coupled Transport. The Journal of Biological Chemistry. 101220. PMID 34562455 DOI: 10.1016/j.jbc.2021.101220  0.746
2021 Chen H, Deng J, Cui Q, Chanda B, Henzler-Wildman K. Mapping temperature-dependent conformational change in the voltage-sensing domain of an engineered heat-activated K channel. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33782120 DOI: 10.1073/pnas.2017280118  0.553
2021 Shcherbakov AA, Hisao G, Mandala VS, Thomas NE, Soltani M, Salter EA, Davis JH, Henzler-Wildman KA, Hong M. Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers. Nature Communications. 12: 172. PMID 33420032 DOI: 10.1038/s41467-020-20468-7  0.768
2020 Hussey GA, Thomas NE, Henzler-Wildman KA. Highly coupled transport can be achieved in free-exchange transport models. The Journal of General Physiology. 152. PMID 31816638 DOI: 10.1085/jgp.201912437  0.761
2020 Thomas N, Wu C, Spreacker P, Hussey G, Wynne S, Uhlemann E, Tate C, DeKoster GT, Henzler-Wildman K. Controlling the Rate and Efficiency of Proton-Coupled Transport by EmrE Biophysical Journal. 118: 2a. DOI: 10.1016/J.Bpj.2019.11.205  0.435
2019 Chen H, Pan J, Gandhi DM, Dockendorff C, Cui Q, Chanda B, Henzler-Wildman KA. NMR Structural Analysis of Isolated Shaker Voltage-Sensing Domain in LPPG Micelles. Biophysical Journal. PMID 31301804 DOI: 10.1016/J.Bpj.2019.06.020  0.59
2019 Wu C, Wynne SA, Thomas NE, Uhlemann EM, Tate CG, Henzler-Wildman KA. Identification of an Alternating-Access Dynamics Mutant of EmrE with Impaired Transport. Journal of Molecular Biology. PMID 31158365 DOI: 10.1016/j.jmb.2019.05.035  0.769
2018 Thomas NE, Wu C, Morrison EA, Robinson AE, Werner JP, Henzler-Wildman K. The C terminus of the bacterial multidrug transporter EmrE couples drug binding to proton release. The Journal of Biological Chemistry. PMID 30287687 DOI: 10.1074/jbc.RA118.005430  0.796
2018 Robinson AE, Henderson JP, Henzler-Wildman KA. A mass spectrometry based transport assay for studying EmrE transport of unlabeled substrates. Analytical Biochemistry. PMID 29559333 DOI: 10.1016/J.Ab.2018.03.017  0.664
2017 Robinson AE, Thomas NE, Morrison EA, Balthazor BM, Henzler-Wildman KA. New free-exchange model of EmrE transport. Proceedings of the National Academy of Sciences of the United States of America. PMID 29114048 DOI: 10.1073/pnas.1708671114  0.801
2015 Morrison EA, Robinson AE, Liu Y, Henzler-Wildman KA. Asymmetric protonation of EmrE. The Journal of General Physiology. PMID 26573622 DOI: 10.1085/jgp.201511404  0.781
2014 Dutta S, Morrison EA, Henzler-Wildman KA. Blocking dynamics of the SMR transporter EmrE impairs efflux activity. Biophysical Journal. 107: 613-20. PMID 25099800 DOI: 10.1016/J.Bpj.2014.06.030  0.748
2014 Dutta S, Morrison EA, Henzler-Wildman KA. EmrE dimerization depends on membrane environment. Biochimica Et Biophysica Acta. 1838: 1817-22. PMID 24680655 DOI: 10.1016/J.Bbamem.2014.03.013  0.706
2014 Morrison EA, Henzler-Wildman KA. Transported substrate determines exchange rate in the multidrug resistance transporter EmrE. The Journal of Biological Chemistry. 289: 6825-36. PMID 24448799 DOI: 10.1074/jbc.M113.535328  0.765
2013 Hulse RE, Henzler-Wildman K, Perozo E. Dynamics of Conformational Transitions during KcsA Gating from EPR and Solution NMR Experiments Biophysical Journal. 104: 128a. DOI: 10.1016/J.Bpj.2012.11.734  0.356
2012 Morrison EA, Henzler-Wildman KA. Reconstitution of integral membrane proteins into isotropic bicelles with improved sample stability and expanded lipid composition profile. Biochimica Et Biophysica Acta. 1818: 814-20. PMID 22226849 DOI: 10.1016/j.bbamem.2011.12.020  0.665
2012 Morrison EA, DeKoster GT, Dutta S, Vafabakhsh R, Clarkson MW, Bahl A, Kern D, Ha T, Henzler-Wildman KA. Antiparallel EmrE exports drugs by exchanging between asymmetric structures. Nature. 481: 45-50. PMID 22178925 DOI: 10.1038/Nature10703  0.8
2012 Henzler-Wildman K. Analyzing conformational changes in the transport cycle of EmrE Current Opinion in Structural Biology. 22: 38-43. PMID 22100111 DOI: 10.1016/J.Sbi.2011.10.004  0.515
2012 Morrison E, Dekoster G, Dutta S, Clarkson M, Vafabakhsh R, Kern D, Ha T, Henzler-Wildman K. Direct Observation of Conformational Exchange in the Small Multidrug Resistance Transporter EmrE Biophysical Journal. 102: 215a. DOI: 10.1016/J.Bpj.2011.11.1179  0.698
2010 Henzler-Wildman K, Morrison E, Dekoster G, Bansal S. Protein Dynamics in the Transport Cycle: NMR Study of the Multidrug Resistance Transporter, EmrE Biophysical Journal. 98: 6-8. DOI: 10.1016/J.Bpj.2009.12.3438  0.554
2008 Ramamoorthy A, Lee DK, Santos JS, Henzler-Wildman KA. Nitrogen-14 solid-state NMR spectroscopy of aligned phospholipid bilayers to probe peptide-lipid interaction and oligomerization of membrane associated peptides. Journal of the American Chemical Society. 130: 11023-9. PMID 18646853 DOI: 10.1021/Ja802210U  0.715
2008 Porcelli F, Verardi R, Shi L, Henzler-Wildman KA, Ramamoorthy A, Veglia G. NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry. 47: 5565-72. PMID 18439024 DOI: 10.1021/Bi702036S  0.443
2007 Henzler-Wildman K, Kern D. Dynamic personalities of proteins Nature. 450: 964-972. PMID 18075575 DOI: 10.1038/Nature06522  0.514
2007 Henzler-Wildman KA, Lei M, Thai V, Kerns SJ, Karplus M, Kern D. A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature. 450: 913-6. PMID 18026087 DOI: 10.1038/Nature06407  0.735
2007 Henzler-Wildman KA, Thai V, Lei M, Ott M, Wolf-Watz M, Fenn T, Pozharski E, Wilson MA, Petsko GA, Karplus M, Hübner CG, Kern D. Intrinsic motions along an enzymatic reaction trajectory. Nature. 450: 838-44. PMID 18026086 DOI: 10.1038/Nature06410  0.775
2006 Moon JY, Henzler-Wildman KA, Ramamoorthy A. Expression and purification of a recombinant LL-37 from Escherichia coli. Biochimica Et Biophysica Acta. 1758: 1351-8. PMID 16542635 DOI: 10.1016/J.Bbamem.2006.02.003  0.41
2004 Wolf-Watz M, Thai V, Henzler-Wildman K, Hadjipavlou G, Eisenmesser EZ, Kern D. Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair Nature Structural and Molecular Biology. 11: 945-949. PMID 15334070 DOI: 10.1038/Nsmb821  0.759
2004 Henzler-Wildman KA, Martinez GV, Brown MF, Ramamoorthy A. Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37. Biochemistry. 43: 8459-69. PMID 15222757 DOI: 10.1021/Bi036284S  0.4
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