John F. Hunt, Ph.D. - Publications

Affiliations: 
1993 Molecular Biophysics Yale University, New Haven, CT 
 1992-1997 Medical Center U. Texas - Southwestern 
 1997- Biological Sciences Columbia University, New York, NY 
Area:
Biophysics
Website:
https://www.biology.columbia.edu/people/hunt

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Li Y, Zhang R, Wang C, Forouhar F, Clarke OB, Vorobiev S, Singh S, Montelione GT, Szyperski T, Xu Y, Hunt JF. Oligomeric interactions maintain active-site structure in a noncooperative enzyme family. The Embo Journal. e108368. PMID 35801308 DOI: 10.15252/embj.2021108368  0.447
2021 Bahia MS, Khazanov N, Zhou Q, Yang Z, Wang C, Hong JS, Rab A, Sorscher EJ, Brouillette CG, Hunt JF, Senderowitz H. Stability Prediction for Mutations in the Cytosolic Domains of Cystic Fibrosis Transmembrane Conductance Regulator. Journal of Chemical Information and Modeling. PMID 33720715 DOI: 10.1021/acs.jcim.0c01207  0.435
2018 Wang C, Aleksandrov AA, Yang Z, Forouhar F, Proctor EA, Kota P, An J, Kaplan A, Khazanov N, Boël G, Stockwell BR, Senderowitz H, Dokholyan NV, Riordan JR, Brouillette CG, ... Hunt JF, et al. Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. PMID 29903914 DOI: 10.1074/Jbc.Ra117.000819  0.453
2014 Yang Z, Wang C, Zhou Q, An J, Hildebrandt E, Aleksandrov LA, Kappes JC, DeLucas LJ, Riordan JR, Urbatsch IL, Hunt JF, Brouillette CG. Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains. Protein Science : a Publication of the Protein Society. 23: 769-89. PMID 24652590 DOI: 10.1002/Pro.2460  0.491
2014 Chen B, Boël G, Hashem Y, Ning W, Fei J, Wang C, Gonzalez RL, Hunt JF, Frank J. EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics. Nature Structural & Molecular Biology. 21: 152-9. PMID 24389465 DOI: 10.1038/Nsmb.2741  0.43
2013 Uemura Y, Nakagawa N, Wakamatsu T, Kim K, Montelione GT, Hunt JF, Kuramitsu S, Masui R. Crystal structure of the ligand-binding form of nanoRNase from Bacteroides fragilis, a member of the DHH/DHHA1 phosphoesterase family of proteins. Febs Letters. 587: 2669-74. PMID 23851074 DOI: 10.1016/J.Febslet.2013.06.053  0.316
2013 Hunt JF, Wang C, Ford RC. Cystic fibrosis transmembrane conductance regulator (ABCC7) structure. Cold Spring Harbor Perspectives in Medicine. 3: a009514. PMID 23378596 DOI: 10.1101/cshperspect.a009514  0.488
2013 Kim DM, Zheng H, Huang YJ, Montelione GT, Hunt JF. ATPase active-site electrostatic interactions control the global conformation of the 100 kDa SecA translocase. Journal of the American Chemical Society. 135: 2999-3010. PMID 23167435 DOI: 10.1021/Ja306361Q  0.302
2012 Pastore C, Topalidou I, Forouhar F, Yan AC, Levy M, Hunt JF. Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. The Journal of Biological Chemistry. 287: 2130-43. PMID 22065580 DOI: 10.1074/Jbc.M111.286187  0.313
2011 Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, et al. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins. 79: 6-20. PMID 22020785 DOI: 10.1002/Prot.23196  0.318
2010 Arbing MA, Handelman SK, Kuzin AP, Verdon G, Wang C, Su M, Rothenbacher FP, Abashidze M, Liu M, Hurley JM, Xiao R, Acton T, Inouye M, Montelione GT, Woychik NA, ... Hunt JF, et al. Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems. Structure (London, England : 1993). 18: 996-1010. PMID 20696400 DOI: 10.1016/J.Str.2010.04.018  0.42
2010 Love J, Mancia F, Shapiro L, Punta M, Rost B, Girvin M, Wang DN, Zhou M, Hunt JF, Szyperski T, Gouaux E, MacKinnon R, McDermott A, Honig B, Inouye M, et al. The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. Journal of Structural and Functional Genomics. 11: 191-9. PMID 20690043 DOI: 10.1007/S10969-010-9094-7  0.468
2010 Wang C, Protasevich I, Yang Z, Seehausen D, Skalak T, Zhao X, Atwell S, Emtage JS, Wetmore DR, Brouillette CG, Hunt JF. Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis Protein Science. 19: 1932-1947. PMID 20687163 DOI: 10.1002/pro.480  0.483
2010 Protasevich I, Yang Z, Wang C, Atwell S, Zhao X, Emtage S, Wetmore D, Hunt JF, Brouillette CG. Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1 Protein Science. 19: 1917-1931. PMID 20687133 DOI: 10.1002/pro.479  0.406
2010 Atwell S, Brouillette CG, Conners K, Emtage S, Gheyi T, Guggino WB, Hendle J, Hunt JF, Lewis HA, Lu F, Protasevich II, Rodgers LA, Romero R, Wasserman SR, Weber PC, et al. Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant. Protein Engineering, Design & Selection : Peds. 23: 375-84. PMID 20150177 DOI: 10.1093/Protein/Gzq004  0.41
2009 Punta M, Love J, Handelman S, Hunt JF, Shapiro L, Hendrickson WA, Rost B. Structural genomics target selection for the New York consortium on membrane protein structure. Journal of Structural and Functional Genomics. 10: 255-68. PMID 19859826 DOI: 10.1007/S10969-009-9071-1  0.452
2005 Lewis HA, Zhao X, Wang C, Sauder JM, Rooney I, Noland BW, Lorimer D, Kearins MC, Conners K, Condon B, Maloney PC, Guggino WB, Hunt JF, Emtage S. Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure. The Journal of Biological Chemistry. 280: 1346-53. PMID 15528182 DOI: 10.1074/Jbc.M410968200  0.52
2004 Lewis HA, Buchanan SG, Burley SK, Conners K, Dickey M, Dorwart M, Fowler R, Gao X, Guggino WB, Hendrickson WA, Hunt JF, Kearins MC, Lorimer D, Maloney PC, Post KW, et al. Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. The Embo Journal. 23: 282-93. PMID 14685259 DOI: 10.1038/Sj.Emboj.7600040  0.52
2003 Ding H, Hunt JF, Mukerji I, Oliver D. Bacillus subtilis SecA ATPase exists as an antiparallel dimer in solution. Biochemistry. 42: 8729-38. PMID 12873133 DOI: 10.1021/Bi0342057  0.307
2003 Hunt JF, Deisenhofer J. Ping-pong cross-validation in real space: a method for increasing the phasing power of a partial model without risk of model bias. Acta Crystallographica. Section D, Biological Crystallography. 59: 214-24. PMID 12554932 DOI: 10.1107/S0907444902018930  0.441
2002 Karpowich NK, Huang HH, Smith PC, Hunt JF. Crystal structures of the BtuF periplasmic-binding protein for vitamin B12 suggest a functionally important reduction in protein mobility upon ligand binding. The Journal of Biological Chemistry. 278: 8429-34. PMID 12468528 DOI: 10.1074/JBC.M212239200  0.301
2002 Hunt JF, Weinkauf S, Henry L, Fak JJ, McNicholas P, Oliver DB, Deisenhofer J. Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA. Science (New York, N.Y.). 297: 2018-26. PMID 12242434 DOI: 10.1126/Science.1074424  0.522
2002 Smith PC, Firestein S, Hunt JF. The crystal structure of the olfactory marker protein at 2.3 A resolution. Journal of Molecular Biology. 319: 807-21. PMID 12054872 DOI: 10.1016/S0022-2836(02)00242-5  0.309
2002 Berger AL, Ikuma M, Hunt JF, Thomas PJ, Welsh MJ. Mutations that change the position of the putative gamma-phosphate linker in the nucleotide binding domains of CFTR alter channel gating. The Journal of Biological Chemistry. 277: 2125-31. PMID 11788611 DOI: 10.1074/Jbc.M109539200  0.302
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