Barrie Wilkinson - Publications

John Innes Centre, UK 
Biosynthesis, natural products, chemical biology

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Gomez-Escribano JP, Algora Gallardo L, Bozhüyük KAJ, Kendrew SG, Huckle BD, Crowhurst NA, Bibb MJ, Collis AJ, Micklefield J, Herron PR, Wilkinson B. Genome editing reveals that pSCL4 is required for chromosome linearity in . Microbial Genomics. 7. PMID 34747689 DOI: 10.1099/mgen.0.000669  0.668
2019 Bozhüyük KA, Micklefield J, Wilkinson B. Engineering enzymatic assembly lines to produce new antibiotics. Current Opinion in Microbiology. 51: 88-96. PMID 31743841 DOI: 10.1016/J.Mib.2019.10.007  0.692
2019 Vikeli E, Widdick DA, Batey SF, Heine D, Holmes NA, Bibb MJ, Martins DJ, Pierce NE, Hutchings MI, Wilkinson B. activation and heterologous production of a cryptic lantibiotic from a plant-ant derived species. Applied and Environmental Microbiology. PMID 31732571 DOI: 10.1128/AEM.01876-19  0.311
2018 Heine D, Holmes NA, Worsley SF, Santos ACA, Innocent TM, Scherlach K, Patrick EH, Yu DW, Murrell JC, Vieria PC, Boomsma JJ, Hertweck C, Hutchings MI, Wilkinson B. Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen. Nature Communications. 9: 2208. PMID 29880868 DOI: 10.1038/S41467-018-04520-1  0.425
2017 Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, ... ... Wilkinson B, et al. Diversity oriented biosynthesis via accelerated evolution of modular gene clusters. Nature Communications. 8: 1206. PMID 29089518 DOI: 10.1038/S41467-017-01344-3  0.575
2015 Law BJC, Struck AW, Bennett MR, Wilkinson B, Micklefield J. Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase. Chemical Science. 6: 2885-2892. PMID 29403635 DOI: 10.1039/C5Sc00164A  0.69
2015 Alt S, Wilkinson B. Biosynthesis of the Novel Macrolide Antibiotic Anthracimycin. Acs Chemical Biology. 10: 2468-79. PMID 26349074 DOI: 10.1021/acschembio.5b00525  0.326
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Wilkinson B, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890  0.708
2015 Schäfer M, Le TB, Hearnshaw SJ, Maxwell A, Challis GL, Wilkinson B, Buttner MJ. SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone. Journal of Molecular Biology. 427: 2192-204. PMID 25861759 DOI: 10.1016/J.Jmb.2015.03.019  0.303
2012 Wu MC, Law B, Wilkinson B, Micklefield J. Bioengineering natural product biosynthetic pathways for therapeutic applications. Current Opinion in Biotechnology. 23: 931-40. PMID 22487048 DOI: 10.1016/J.Copbio.2012.03.008  0.715
2011 Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, ... ... Wilkinson B, et al. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chemical Science (Royal Society of Chemistry : 2010). 2011: 273-278. PMID 22822423 DOI: 10.1039/C0Sc00297F  0.706
2011 Qu X, Jiang N, Xu F, Shao L, Tang G, Wilkinson B, Liu W. Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor. Molecular Biosystems. 7: 852-61. PMID 21416665 DOI: 10.1039/C0Mb00234H  0.336
2011 Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, ... ... Wilkinson B, et al. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. Proceedings of the National Academy of Sciences of the United States of America. 108: 4776-81. PMID 21383123 DOI: 10.1073/Pnas.1015773108  0.559
2009 Wilkinson B, Micklefield J. Chapter 14. Biosynthesis of nonribosomal peptide precursors. Methods in Enzymology. 458: 353-78. PMID 19374990 DOI: 10.1016/S0076-6879(09)04814-9  0.691
2008 Schell U, Haydock SF, Kaja AL, Carletti I, Lill RE, Read E, Sheehan LS, Low L, Fernandez MJ, Grolle F, McArthur HA, Sheridan RM, Leadlay PF, Wilkinson B, Gaisser S. Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties. Organic & Biomolecular Chemistry. 6: 3315-27. PMID 18802638 DOI: 10.1039/B807914E  0.506
2008 Petkovi? H, Sandmann A, Challis IR, Hecht HJ, Silakowski B, Low L, Beeston N, Kuscer E, Garcia-Bernardo J, Leadlay PF, Kendrew SG, Wilkinson B, Müller R. Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase. Organic & Biomolecular Chemistry. 6: 500-6. PMID 18219420 DOI: 10.1039/B714804F  0.598
2007 Powell A, Borg M, Amir-Heidari B, Neary JM, Thirlway J, Wilkinson B, Smith CP, Micklefield J. Engineered biosynthesis of nonribosomal lipopeptides with modified fatty acid side chains. Journal of the American Chemical Society. 129: 15182-91. PMID 18020333 DOI: 10.1021/Ja074331O  0.713
2007 Powell A, Al Nakeeb M, Wilkinson B, Micklefield J. Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues. Chemical Communications (Cambridge, England). 2683-5. PMID 17594019 DOI: 10.1039/B706224A  0.668
2007 Wilkinson B, Micklefield J. Mining and engineering natural-product biosynthetic pathways. Nature Chemical Biology. 3: 379-86. PMID 17576425 DOI: 10.1038/Nchembio.2007.7  0.72
2007 Kuscer E, Coates N, Challis I, Gregory M, Wilkinson B, Sheridan R, Petković H. Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus. Journal of Bacteriology. 189: 4756-63. PMID 17468238 DOI: 10.1128/JB.00129-07  0.315
2007 Neary JM, Powell A, Gordon L, Milne C, Flett F, Wilkinson B, Smith CP, Micklefield J. An asparagine oxygenase (AsnO) and a 3-hydroxyasparaginyl phosphotransferase (HasP) are involved in the biosynthesis of calcium-dependent lipopeptide antibiotics. Microbiology (Reading, England). 153: 768-76. PMID 17322197 DOI: 10.1099/Mic.0.2006/002725-0  0.718
2006 Sheehan LS, Lill RE, Wilkinson B, Sheridan RM, Vousden WA, Kaja AL, Crouse GD, Gifford J, Graupner PR, Karr L, Lewer P, Sparks TC, Leadlay PF, Waldron C, Martin CJ. Engineering of the spinosyn PKS: directing starter unit incorporation. Journal of Natural Products. 69: 1702-10. PMID 17190446 DOI: 10.1021/Np0602517  0.524
2006 Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, ... Wilkinson B, et al. Rapamycin biosynthesis: Elucidation of gene product function. Organic & Biomolecular Chemistry. 4: 3565-8. PMID 16990929 DOI: 10.1039/B608813A  0.511
2006 Wilkinson B, Gregory MA, Moss SJ, Carletti I, Sheridan RM, Kaja A, Ward M, Olano C, Mendez C, Salas JA, Leadlay PF, vanGinckel R, Zhang MQ. Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain. Bioorganic & Medicinal Chemistry Letters. 16: 5814-7. PMID 16962775 DOI: 10.1016/J.Bmcl.2006.08.073  0.478
2006 Moss SJ, Carletti I, Olano C, Sheridan RM, Ward M, Math V, Nur-E-Alam M, Braña AF, Zhang MQ, Leadlay PF, Méndez C, Salas JA, Wilkinson B. Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues. Chemical Communications (Cambridge, England). 2341-3. PMID 16733573 DOI: 10.1039/B602931K  0.471
2005 Gregory MA, Petkovic H, Lill RE, Moss SJ, Wilkinson B, Gaisser S, Leadlay PF, Sheridan RM. Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis. Angewandte Chemie (International Ed. in English). 44: 4757-60. PMID 15977283 DOI: 10.1002/Anie.200462784  0.482
2004 Olano C, Moss SJ, Braña AF, Sheridan RM, Math V, Weston AJ, Méndez C, Leadlay PF, Wilkinson B, Salas JA. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation. Molecular Microbiology. 52: 1745-56. PMID 15186422 DOI: 10.1111/J.1365-2958.2004.04090.X  0.556
2004 Gregory MA, Gaisser S, Lill RE, Hong H, Sheridan RM, Wilkinson B, Petkovic H, Weston AJ, Carletti I, Lee HL, Staunton J, Leadlay PF. Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus. Angewandte Chemie (International Ed. in English). 43: 2551-3. PMID 15127450 DOI: 10.1002/Anie.200453764  0.58
2004 Olano C, Wilkinson B, Sánchez C, Moss SJ, Sheridan R, Math V, Weston AJ, Braña AF, Martin CJ, Oliynyk M, Méndez C, Leadlay PF, Salas JA. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chemistry & Biology. 11: 87-97. PMID 15112998 DOI: 10.1016/J.Chembiol.2003.12.018  0.549
2003 Martin CJ, Timoney MC, Sheridan RM, Kendrew SG, Wilkinson B, Staunton JC, Leadlay PF. Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase. Organic & Biomolecular Chemistry. 1: 4144-7. PMID 14685317 DOI: 10.1039/B310740J  0.635
2003 Olano C, Wilkinson B, Moss SJ, Braña AF, Méndez C, Leadlay PF, Salas JA. Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. Chemical Communications (Cambridge, England). 2780-2. PMID 14651102 DOI: 10.1039/B310648A  0.476
2003 Gaisser S, Kellenberger L, Kaja AL, Weston AJ, Lill RE, Wirtz G, Kendrew SG, Low L, Sheridan RM, Wilkinson B, Galloway IS, Stutzman-Engwall K, McArthur HA, Staunton J, Leadlay PF. Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. Organic & Biomolecular Chemistry. 1: 2840-7. PMID 12968333 DOI: 10.1039/B304022D  0.607
2003 Petkovic H, Lill RE, Sheridan RM, Wilkinson B, McCormick EL, McArthur HA, Staunton J, Leadlay PF, Kendrew SG. A novel erythromycin, 6-desmethyl erythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase. The Journal of Antibiotics. 56: 543-51. PMID 12931864 DOI: 10.7164/Antibiotics.56.543  0.613
2003 Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortés J, Rudd BA, Staunton J, Leadlay PF. Active-site residue, domain and module swaps in modular polyketide synthases. Journal of Industrial Microbiology & Biotechnology. 30: 489-94. PMID 12811585 DOI: 10.1007/S10295-003-0062-0  0.61
2002 Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J. Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor. Chemistry & Biology. 9: 1175-87. PMID 12445768 DOI: 10.1016/S1074-5521(02)00252-1  0.723
2002 Gaisser S, Martin CJ, Wilkinson B, Sheridan RM, Lill RE, Weston AJ, Ready SJ, Waldron C, Crouse GD, Leadlay PF, Staunton J. Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents. Chemical Communications (Cambridge, England). 618-9. PMID 12120151 DOI: 10.1039/B200536K  0.586
2001 Lowden PA, Wilkinson B, Böhm GA, Handa S, Floss HG, Leadlay PF, Staunton J. Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.). Angewandte Chemie (International Ed. in English). 40: 777-779. PMID 11241621 DOI: 10.1002/1521-3773(20010216)40:4<777::Aid-Anie7770>3.0.Co;2-9  0.625
1997 Staunton J, Wilkinson B. Biosynthesis of Erythromycin and Rapamycin. Chemical Reviews. 97: 2611-2630. PMID 11851474 DOI: 10.1021/Cr9600316  0.467
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