Keary Mark Engle, Ph.D., D.Phil. - Publications

Affiliations: 
Chemistry Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
organic synthesis, organometallics, catalysis
Website:
www.englelab.com

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Nimmagadda SK, Liu M, Karunananda MK, Gao DW, Apolinar O, Chen JS, Liu P, Engle KM. Catalytic, Enantioselective α-Alkylation of Azlactones with Non-Conjugated Alkenes via Directed Nucleopalladation. Angewandte Chemie (International Ed. in English). PMID 30729619 DOI: 10.1002/anie.201814272  0.76
2018 O'Duill ML, Engle KM. Protodepalladation as a Strategic Elementary Step in Catalysis. Synthesis. 50: 4699-4714. PMID 31105348 DOI: 10.1055/s-0037-1611064  1
2018 Gao DW, Xiao Y, Liu M, Liu Z, Karunananda MK, Chen JS, Engle KM. Catalytic, Enantioselective Synthesis of Allenyl Boronates. Acs Catalysis. 8: 3650-3654. PMID 30740261 DOI: 10.1021/acscatal.8b00626  0.84
2018 Matsuura R, Jankins TC, Hill DE, Yang KS, Gallego GM, Yang S, He M, Wang F, Marsters RP, McAlpine I, Engle KM. Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids. Chemical Science. 9: 8363-8368. PMID 30542583 DOI: 10.1039/c8sc03081b  0.92
2018 Derosa J, Kleinmans R, Tran VT, Karunananda MK, Wisniewski SR, Eastgate MD, Engle KM. Nickel-Catalyzed 1,2-Diarylation of Simple Alkenyl Amides. Journal of the American Chemical Society. PMID 30525575 DOI: 10.1021/jacs.8b11942  0.84
2018 Gurak JA, Engle KM. Practical Intermolecular Hydroarylation of Terminal Alkenes via Reductive Heck Coupling. Acs Catalysis. 8: 8987-8992. PMID 30393575 DOI: 10.1021/acscatal.8b02717  0.56
2018 Tran VT, Gurak JA, Yang KS, Engle KM. Activation of diverse carbon-heteroatom and carbon-carbon bonds via palladium(II)-catalysed β-X elimination. Nature Chemistry. PMID 30127512 DOI: 10.1038/s41557-018-0110-z  0.92
2018 Derosa J, van der Puyl VA, Tran VT, Liu M, Engle KM. Directed nickel-catalyzed 1,2-dialkylation of alkenyl carbonyl compounds. Chemical Science. 9: 5278-5283. PMID 29997883 DOI: 10.1039/c8sc01735b  0.84
2018 Gao DW, Vinogradova EV, Nimmagadda SK, Medina JM, Xiao Y, Suciu RM, Cravatt BF, Engle KM. Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes. Journal of the American Chemical Society. PMID 29894184 DOI: 10.1021/jacs.8b03704  0.76
2018 Zeng T, Liu Z, Schmidt MA, Eastgate MD, Engle KM. Directed, Palladium(II)-Catalyzed Intermolecular Aminohydroxylation of Alkenes Using a Mild Oxidation System. Organic Letters. PMID 29888604 DOI: 10.1021/acs.orglett.8b01440  0.84
2018 Liu M, Yang P, Karunananda MK, Wang Y, Liu P, Engle KM. C(alkenyl)-H Activation via Six-Membered Palladacycles: Catalytic 1,3-Diene Synthesis. Journal of the American Chemical Society. PMID 29630359 DOI: 10.1021/jacs.8b02124  0.76
2018 Derosa J, O'Duill ML, Holcomb M, Boulous MN, Patman RL, Wang F, Tran-Dubé M, McAlpine I, Engle KM. Copper-Catalyzed Chan-Lam Cyclopropylation of Phenols and Azaheterocycles. The Journal of Organic Chemistry. PMID 29498847 DOI: 10.1021/acs.joc.7b03100  1
2018 Liu Z, Ni HQ, Zeng T, Engle KM. Catalytic Carbo- and Aminoboration of Alkenyl Carbonyl Compounds via 5- and 6-Membered Palladacycles. Journal of the American Chemical Society. PMID 29384373 DOI: 10.1021/jacs.8b00881  0.84
2017 O'Duill ML, Matsuura R, Wang Y, Turnbull JL, Gurak JA, Gao DW, Lu G, Liu P, Engle KM. Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization. Journal of the American Chemical Society. PMID 28972751 DOI: 10.1021/jacs.7b08383  1
2017 Derosa J, Tran V, Boulous MN, Chen JS, Engle KM. Nickel-Catalyzed β,γ-Dicarbofunctionalization of Alkenyl Carbonyl Compounds via Conjunctive Cross-Coupling. Journal of the American Chemical Society. PMID 28738150 DOI: 10.1021/jacs.7b06567  0.84
2017 Liu Z, Wang Y, Wang Z, Zeng T, Liu P, Engle KM. Catalytic Intermolecular Carboamination of Unactivated Alkenes via Directed Aminopalladation. Journal of the American Chemical Society. PMID 28727452 DOI: 10.1021/jacs.7b06520  0.84
2017 Derosa J, Cantu AL, Boulous MN, O'Duill ML, Turnbull JL, Liu Z, De La Torre DM, Engle KM. Palladium(II)-Catalyzed Directed anti-Hydrochlorination of Unactivated Alkynes with HCl. Journal of the American Chemical Society. PMID 28266849 DOI: 10.1021/jacs.7b00892  1
2016 Liu Z, Zeng T, Yang KS, Engle KM. β,γ-Vicinal Dicarbofunctionalization of Alkenyl Carbonyl Compounds via Directed Nucleopalladation. Journal of the American Chemical Society. PMID 27779861 DOI: 10.1021/jacs.6b09170  0.92
2016 Yang KS, Gurak JA, Liu Z, Engle KM. Catalytic, Regioselective Hydrocarbofunctionalization of Unactivated Alkenes with Diverse C-H Nucleophiles. Journal of the American Chemical Society. PMID 27709911 DOI: 10.1021/jacs.6b08850  0.92
2016 Luo SX, Cannon JS, Taylor BL, Engle KM, Houk KN, Grubbs RH. Z-Selective Cross-Metathesis and Homodimerization of 3E-1,3-Dienes: Reaction Optimization, Computational Analysis, and Synthetic Applications. Journal of the American Chemical Society. PMID 27689541 DOI: 10.1021/jacs.6b08387  0.72
2016 Pfeifer L, Engle KM, Pidgeon GW, Sparkes HA, Thompson AL, Brown JM, Gouverneur VE. Hydrogen-Bonded Homoleptic Fluoride-Diarylurea Complexes: Structure, Reactivity and Coordinating Power. Journal of the American Chemical Society. PMID 27608274 DOI: 10.1021/jacs.6b07501  1
2016 Liu Z, Derosa J, Engle KM. Palladium(II)-Catalyzed Regioselective syn-Hydroarylation of Disubstituted Alkynes Using a Removable Directing Group. Journal of the American Chemical Society. PMID 27602748 DOI: 10.1021/jacs.6b08818  0.84
2016 Lee J, Grandner JM, Engle KM, Houk KN, Grubbs RH. In Situ Catalyst Modification in Atom Transfer Radical Reactions with Ruthenium Benzylidene Complexes. Journal of the American Chemical Society. 138: 7171-7. PMID 27186790 DOI: 10.1021/jacs.6b03767  0.72
2016 Yang KS, Engle KM. Organic chemistry: Precision pruning of molecules. Nature. 533: 183-184. PMID 27172040 DOI: 10.1038/533183a  1
2016 Gurak JA, Yang KS, Liu Z, Engle KM. Directed, Regiocontrolled Hydroamination of Unactivated Alkenes via Protodepalladation. Journal of the American Chemical Society. PMID 27093112 DOI: 10.1021/jacs.6b02718  0.92
2016 Engle KM. The mechanism of palladium(II)-mediated C-H cleavage with mono-N-protected amino acid (MPAA) ligands: Origins of rate acceleration Pure and Applied Chemistry. 88: 119-138. DOI: 10.1515/pac-2015-0902  1
2015 Engle KM, Pfeifer L, Pidgeon GW, Giuffredi GT, Thompson AL, Paton RS, Brown JM, Gouverneur V. Coordination diversity in hydrogen-bonded homoleptic fluoride-alcohol complexes modulates reactivity. Chemical Science. 6: 5293-5302. PMID 29449931 DOI: 10.1039/c5sc01812a  0.64
2015 Engle KM, Dastbaravardeh N, Thuy-Boun PS, Wang DH, Sather AC, Yu JQ. Ligand-Accelerated ortho-C-H Olefination of Phenylacetic Acids. Organic Syntheses; An Annual Publication of Satisfactory Methods For the Preparation of Organic Chemicals. 92: 58-75. PMID 27397943 DOI: 10.15227/orgsyn.092.0058  1
2015 Engle KM, Lu G, Luo SX, Henling LM, Takase MK, Liu P, Houk KN, Grubbs RH. Origins of initiation rate differences in ruthenium olefin metathesis catalysts containing chelating benzylidenes. Journal of the American Chemical Society. 137: 5782-92. PMID 25897653 DOI: 10.1021/jacs.5b01144  0.76
2015 Koy M, Engle KM, Henling LM, Takase MK, Grubbs RH. Synthesis of substituted dihydrobenzofurans via tandem S(N)Ar/5-exo-trig cyclization. Organic Letters. 17: 1986-9. PMID 25853213 DOI: 10.1021/acs.orglett.5b00743  0.72
2015 Engle KM, Luo SX, Grubbs RH. An S(N)Ar approach to sterically hindered ortho-alkoxybenzaldehydes for the synthesis of olefin metathesis catalysts. The Journal of Organic Chemistry. 80: 4213-20. PMID 25826714 DOI: 10.1021/acs.joc.5b00563  0.72
2015 Wang XC, Gong W, Fang LZ, Zhu RY, Li S, Engle KM, Yu JQ. Ligand-enabled meta-C-H activation using a transient mediator. Nature. 519: 334-8. PMID 25754328 DOI: 10.1038/nature14214  1
2015 Engle KM, Pfeifer L, Pidgeon GW, Giuffredi GT, Thompson AL, Paton RS, Brown JM, Gouverneur V. Coordination diversity in hydrogen-bonded homoleptic fluoride-alcohol complexes modulates reactivity Chemical Science. 6: 5293-5302. DOI: 10.1039/c5sc01812a  1
2013 Wolstenhulme JR, Rosenqvist J, Lozano O, Ilupeju J, Wurz N, Engle KM, Pidgeon GW, Moore PR, Sandford G, Gouverneur V. Asymmetric electrophilic fluorocyclization with carbon nucleophiles. Angewandte Chemie (International Ed. in English). 52: 9796-800. PMID 23873744 DOI: 10.1002/anie.201304845  1
2013 Wang H, Li G, Engle KM, Yu JQ, Davies HM. Sequential C-H functionalization reactions for the enantioselective synthesis of highly functionalized 2,3-dihydrobenzofurans. Journal of the American Chemical Society. 135: 6774-7. PMID 23600441 DOI: 10.1021/ja401731d  1
2013 Engle KM, Yu JQ. Developing ligands for palladium(II)-catalyzed C-H functionalization: intimate dialogue between ligand and substrate. The Journal of Organic Chemistry. 78: 8927-55. PMID 23565982 DOI: 10.1021/jo400159y  1
2013 Mizuta S, Engle KM, Verhoog S, Galicia-López O, O'Duill M, Médebielle M, Wheelhouse K, Rassias G, Thompson AL, Gouverneur V. Trifluoromethylation of allylsilanes under photoredox catalysis. Organic Letters. 15: 1250-3. PMID 23465076 DOI: 10.1021/ol400184t  1
2013 Mizuta S, Verhoog S, Engle KM, Khotavivattana T, O'Duill M, Wheelhouse K, Rassias G, Médebielle M, Gouverneur V. Catalytic hydrotrifluoromethylation of unactivated alkenes. Journal of the American Chemical Society. 135: 2505-8. PMID 23373772 DOI: 10.1021/ja401022x  1
2012 Mei TS, Kou L, Ma S, Engle KM, Yu JQ. Heterocycle Formation via Palladium-Catalyzed C-H Functionalization. Synthesis. 44: 1778-1791. PMID 27397938 DOI: 10.1055/s-0031-1289766  1
2012 Mizuta S, Galicia-López O, Engle KM, Verhoog S, Wheelhouse K, Rassias G, Gouverneur V. Trifluoromethylation of allylsilanes under copper catalysis. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 8583-7. PMID 22692972 DOI: 10.1002/chem.201201707  1
2012 Baxter RD, Sale D, Engle KM, Yu JQ, Blackmond DG. Mechanistic rationalization of unusual kinetics in Pd-catalyzed C-H olefination. Journal of the American Chemical Society. 134: 4600-6. PMID 22324814 DOI: 10.1021/ja207634t  1
2012 Engle KM, Mei TS, Wasa M, Yu JQ. Weak coordination as a powerful means for developing broadly useful C-H functionalization reactions. Accounts of Chemical Research. 45: 788-802. PMID 22166158 DOI: 10.1021/ar200185g  1
2012 Mei TS, Kou L, Ma S, Engle K, Yu JQ. Heterocycle formation via palladium-catalyzed C-H functionalization Synthesis (Germany). 44: 1778-1791. DOI: 10.1055/s-0031-1289766  1
2012 Engle KM, Yu JQ, Davies HML, Xi Z, You SL, Shi ZJ. Transition Metal-Catalyzed C-H Functionalization: Synthetically Enabling Reactions for Building Molecular Complexity Organic Chemistry - Breakthroughs and Perspectives. 279-333. DOI: 10.1002/9783527664801.ch8  1
2011 Wasa M, Engle KM, Lin DW, Yoo EJ, Yu JQ. Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. Journal of the American Chemical Society. 133: 19598-601. PMID 22059375 DOI: 10.1021/ja207607s  1
2011 Engle KM, Thuy-Boun PS, Dang M, Yu JQ. Ligand-accelerated cross-coupling of C(sp2)-H bonds with arylboron reagents. Journal of the American Chemical Society. 133: 18183-93. PMID 21913636 DOI: 10.1021/ja203978r  1
2011 Engle KM, Mei TS, Wang X, Yu JQ. Bystanding F+ oxidants enable selective reductive elimination from high-valent metal centers in catalysis. Angewandte Chemie (International Ed. in English). 50: 1478-91. PMID 21264991 DOI: 10.1002/anie.201005142  1
2011 Lu Y, Leow D, Wang X, Engle KM, Yu JQ. Hydroxyl-directed C-H carbonylation enabled by mono-N-protected amino acid ligands: An expedient route to 1-isochromanones Chemical Science. 2: 967-971. DOI: 10.1039/c0sc00633e  1
2010 Wasa M, Engle KM, Yu JQ. Cross-coupling of C(sp)-H Bonds with Organometallic Reagents via Pd(II)/Pd(0) Catalysis** Israel Journal of Chemistry. 50: 605-616. PMID 21552359  1
2010 Engle KM, Wang DH, Yu JQ. Ligand-accelerated C-H activation reactions: evidence for a switch of mechanism. Journal of the American Chemical Society. 132: 14137-51. PMID 20853838 DOI: 10.1021/ja105044s  1
2010 Engle KM, Wang DH, Yu JQ. Constructing multiply substituted arenes using sequential palladium(II)-catalyzed C-H olefination. Angewandte Chemie (International Ed. in English). 49: 6169-73. PMID 20632344 DOI: 10.1002/anie.201002077  1
2010 Lu Y, Wang DH, Engle KM, Yu JQ. Pd(II)-catalyzed hydroxyl-directed C-H olefination enabled by monoprotected amino acid ligands. Journal of the American Chemical Society. 132: 5916-21. PMID 20359184 DOI: 10.1021/ja101909t  1
2010 Wasa M, Engle KM, Yu JQ. Pd(II)-catalyzed olefination of sp3 C-H bonds. Journal of the American Chemical Society. 132: 3680-1. PMID 20187642 DOI: 10.1021/ja1010866  1
2010 Wang DH, Engle KM, Shi BF, Yu JQ. Ligand-enabled reactivity and selectivity in a synthetically versatile aryl C-H olefination. Science (New York, N.Y.). 327: 315-9. PMID 19965380 DOI: 10.1126/science.1182512  1
2010 Wasa M, Engle KM, Yu JQ. Cross-coupling of C(sp3)-H bonds with organometallic reagents via Pd(II)/Pd(0) catalysis Israel Journal of Chemistry. 50: 605-616. DOI: 10.1002/ijch.201000038  1
2009 Giri R, Shi BF, Engle KM, Maugel N, Yu JQ. Transition metal-catalyzed C-H activation reactions: diastereoselectivity and enantioselectivity. Chemical Society Reviews. 38: 3242-72. PMID 19847354 DOI: 10.1039/b816707a  1
2009 Wasa M, Engle KM, Yu JQ. Pd(0)/PR3-catalyzed intermolecular arylation of sp3 C-H bonds. Journal of the American Chemical Society. 131: 9886-7. PMID 19580277 DOI: 10.1021/ja903573p  1
2009 Chen X, Engle KM, Wang DH, Yu JQ. Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality. Angewandte Chemie (International Ed. in English). 48: 5094-115. PMID 19557755 DOI: 10.1002/anie.200806273  1
2007 Plass KE, Engle KM, Matzger AJ. Contrasting two- and three-dimensional crystal properties of isomeric dialkyl phthalates. Journal of the American Chemical Society. 129: 15211-7. PMID 18001022 DOI: 10.1021/ja0744798  1
2006 Plass KE, Engle KM, Cychosz KA, Matzger AJ. Large-periodicity two-dimensional crystals by cocrystallization. Nano Letters. 6: 1178-83. PMID 16771576 DOI: 10.1021/nl0605061  1
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