Robert M. Rzasa, Ph.D. - Publications

1993-1998 Texas A & M University, College Station, TX, United States 
Organic Chemistry

19 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Cushing TD, Hao X, Shin Y, Andrews K, Brown M, Cardozo M, Chen Y, Duquette J, Fisher B, Gonzalez-Lopez de Turiso F, He X, Henne KR, Hu YL, Hungate R, Johnson MG, ... ... Rzasa RM, et al. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. Journal of Medicinal Chemistry. 58: 480-511. PMID 25469863 DOI: 10.1021/jm501624r  1
2014 Rzasa RM, Frohn MJ, Andrews KL, Chmait S, Chen N, Clarine JG, Davis C, Eastwood HA, Horne DB, Hu E, Jones AD, Kaller MR, Kunz RK, Miller S, Monenschein H, et al. Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. Bioorganic & Medicinal Chemistry. 22: 6570-85. PMID 25456383 DOI: 10.1016/j.bmc.2014.10.013  1
2013 Chen JJ, Qian W, Biswas K, Yuan C, Amegadzie A, Liu Q, Nixey T, Zhu J, Ncube M, Rzasa RM, Chavez F, Chen N, DeMorin F, Rumfelt S, Tegley CM, et al. Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 23: 6447-54. PMID 24139583 DOI: 10.1016/j.bmcl.2013.09.041  1
2012 Rzasa RM, Hu E, Rumfelt S, Chen N, Andrews KL, Chmait S, Falsey JR, Zhong W, Jones AD, Porter A, Louie SW, Zhao X, Treanor JJ, Allen JR. Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux. Bioorganic & Medicinal Chemistry Letters. 22: 7371-5. PMID 23149228 DOI: 10.1016/j.bmcl.2012.10.078  1
2012 Bryan MC, Biswas K, Peterkin TA, Rzasa RM, Arik L, Lehto SG, Sun H, Hsieh FY, Xu C, Fremeau RT, Allen JR. Chromenones as potent bradykinin B1 antagonists. Bioorganic & Medicinal Chemistry Letters. 22: 619-22. PMID 22088753 DOI: 10.1016/j.bmcl.2011.10.068  1
2010 Reichelt A, Falsey JR, Rzasa RM, Thiel OR, Achmatowicz MM, Larsen RD, Zhang D. Palladium-catalyzed chemoselective monoarylation of hydrazides for the synthesis of [1,2,4]triazolo[4,3-a]pyridines. Organic Letters. 12: 792-5. PMID 20099864 DOI: 10.1021/ol902868q  1
2009 Kaller MR, Zhong W, Henley C, Magal E, Nguyen T, Powers D, Rzasa RM, Wang W, Xiong X, Norman MH. Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 6591-4. PMID 19864130 DOI: 10.1016/j.bmcl.2009.10.027  1
2008 Herberich B, Cao GQ, Chakrabarti PP, Falsey JR, Pettus L, Rzasa RM, Reed AB, Reichelt A, Sham K, Thaman M, Wurz RP, Xu S, Zhang D, Hsieh F, Lee MR, et al. Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. Journal of Medicinal Chemistry. 51: 6271-9. PMID 18817365 DOI: 10.1021/jm8005417  1
2008 Pettus LH, Xu S, Cao GQ, Chakrabarti PP, Rzasa RM, Sham K, Wurz RP, Zhang D, Middleton S, Henkle B, Plant MH, Saris CJ, Sherman L, Wong LM, Powers DA, et al. 3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase. Journal of Medicinal Chemistry. 51: 6280-92. PMID 18817364 DOI: 10.1021/jm8005405  1
2007 Low WK, Dang Y, Schneider-Poetsch T, Shi Z, Choi NS, Rzasa RM, Shea HA, Li S, Park K, Ma G, Romo D, Liu JO. Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A. Methods in Enzymology. 431: 303-24. PMID 17923240 DOI: 10.1016/S0076-6879(07)31014-8  1
2007 Zhong W, Liu H, Kaller MR, Henley C, Magal E, Nguyen T, Osslund TD, Powers D, Rzasa RM, Wang HL, Wang W, Xiong X, Zhang J, Norman MH. Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 5384-9. PMID 17709247 DOI: 10.1016/j.bmcl.2007.07.045  1
2007 Rzasa RM, Kaller MR, Liu G, Magal E, Nguyen TT, Osslund TD, Powers D, Santora VJ, Viswanadhan VN, Wang HL, Xiong X, Zhong W, Norman MH. Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors. Bioorganic & Medicinal Chemistry. 15: 6574-95. PMID 17697781 DOI: 10.1016/j.bmc.2007.07.005  1
2007 Doherty EM, Fotsch C, Bannon AW, Bo Y, Chen N, Dominguez C, Falsey J, Gavva NR, Katon J, Nixey T, Ognyanov VI, Pettus L, Rzasa RM, Stec M, Surapaneni S, et al. Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. Journal of Medicinal Chemistry. 50: 3515-27. PMID 17585750 DOI: 10.1021/jm070190p  1
2007 Norman MH, Zhu J, Fotsch C, Bo Y, Chen N, Chakrabarti P, Doherty EM, Gavva NR, Nishimura N, Nixey T, Ognyanov VI, Rzasa RM, Stec M, Surapaneni S, Tamir R, et al. Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides. Journal of Medicinal Chemistry. 50: 3497-514. PMID 17585749 DOI: 10.1021/jm070189q  1
2000 Romo D, Rzasa RM, Schmitz WD, Yang J, Cohn ST, Buchler IP, Shea HA, Park K, Langenhan JM, Messerschmidt NB, Cox MM. Total synthesis of marine natural products driven by novel structure, potent biological activity, and/or synthetic methodology. Ernst Schering Research Foundation Workshop. 103-48. PMID 11077607  1
2000 Molander GA, Rzasa RM. Hetero diels-alder reactions catalyzed by the metallocenium complex [Cp(2)Ce][BPh(4)]. The Journal of Organic Chemistry. 65: 1215-7. PMID 10814075 DOI: 10.1021/jo9909195  1
1998 Romo D, Rzasa RM, Shea HA, Park K, Langenhan JM, Sun L, Akhiezer A, Liu JO. Total synthesis and immunosuppressive activity of (-)-pateamine A and related compounds: Implementation of a β-lactam-based macrocyclization Journal of the American Chemical Society. 120: 12237-12254. DOI: 10.1021/ja981846u  1
1998 Rzasa RM, Shea HA, Romo D. Total synthesis of the novel, immunosuppressive agent (-)-pateamine A from Mycale sp. employing a β-lactam-based macrocyclization Journal of the American Chemical Society. 120: 591-592. DOI: 10.1021/ja973549f  1
1995 Rzasa RM, Romo D, Stirling DJ, Blunt JW, Munro MHG. Structural and synthetic studies of the pateamines: Synthesis and absolute configuration of the hydroxydienoate fragment Tetrahedron Letters. 36: 5307-5310. DOI: 10.1016/0040-4039(95)01021-9  1
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