Frank Sicheri - Publications

Biochemistry University of Toronto, Toronto, ON, Canada 
protein kinase regulation

106 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu S. Yeast Two-Hybrid Analysis for Ubiquitin-Variant Inhibitors of Human Deubiquitinases. Journal of Molecular Biology. PMID 30763569 DOI: 10.1016/j.jmb.2019.02.007  0.4
2016 Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D. The structural basis of modified nucleosome recognition by 53BP1. Nature. PMID 27462807 DOI: 10.1038/nature18951  1
2016 Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F. Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Nucleic Acids Research. PMID 27302132 DOI: 10.1093/nar/gkw542  1
2015 Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA, Sicheri F. Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Molecular Cell. 59: 970-83. PMID 26344097 DOI: 10.1016/j.molcel.2015.07.028  1
2015 Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F. Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe. Proceedings of the National Academy of Sciences of the United States of America. 112: E4364-73. PMID 26216977 DOI: 10.1073/pnas.1505481112  0.44
2015 Hunter RW, Zeqiraj E, Morrice N, Sicheri F, Sakamoto K. Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells. Protein Expression and Purification. 108: 23-9. PMID 25527037 DOI: 10.1016/j.pep.2014.12.007  1
2015 Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M. Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation. Nature Structural & Molecular Biology. 22: 37-43. PMID 25437913 DOI: 10.1038/nsmb.2924  1
2015 Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F, Shokat KM. Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe Proceedings of the National Academy of Sciences of the United States of America. 112: E4364-E4373. DOI: 10.1073/pnas.1505481112  1
2015 Zeqiraj E, Sicheri F. Getting a handle on glycogen synthase - Its interaction with glycogenin Molecular Aspects of Medicine. DOI: 10.1016/j.mam.2015.08.004  1
2014 Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri F. Dimerization-induced allostery in protein kinase regulation. Trends in Biochemical Sciences. 39: 475-86. PMID 25220378 DOI: 10.1016/j.tibs.2014.08.004  1
2014 Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, ... ... Sicheri F, et al. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nature Communications. 5: 4202. PMID 25164867 DOI: 10.1038/ncomms5202  1
2014 Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri F. Structural basis for the recruitment of glycogen synthase by glycogenin. Proceedings of the National Academy of Sciences of the United States of America. 111: E2831-40. PMID 24982189 DOI: 10.1073/pnas.1402926111  1
2014 Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, McGlade CJ, Durocher D, Sicheri F. Structural basis of Rad53 kinase activation by dimerization and activation segment exchange Cellular Signalling. 26: 1825-1836. PMID 24815189 DOI: 10.1016/j.cellsig.2014.05.004  1
2014 Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, ... ... Sicheri F, et al. Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Molecular Cell. 53: 221-34. PMID 24462203 DOI: 10.1016/j.molcel.2013.12.025  1
2014 Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F. E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nature Chemical Biology. 10: 156-163. PMID 24316736 DOI: 10.1038/nchembio.1412  1
2014 Keszei AF, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F. Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase. Molecular and Cellular Biology. 34: 362-73. PMID 24248594 DOI: 10.1128/MCB.01360-13  1
2013 Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H, Gingras AC. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Science Signaling. 6: rs15. PMID 24255178 DOI: 10.1126/scisignal.2004712  1
2013 Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature. 499: 50-4. PMID 23760478 DOI: 10.1038/nature12318  1
2013 Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, MacLean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F, Cordes SP. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature. 498: 318-24. PMID 23708998 DOI: 10.1038/nature12296  1
2013 Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien M. Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nature Chemical Biology. 9: 428-36. PMID 23685672 DOI: 10.1038/nchembio.1257  1
2013 Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F. Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Research. 41: 6332-46. PMID 23620299 DOI: 10.1093/nar/gkt322  1
2013 Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, ... ... Sicheri F, et al. A strategy for modulation of enzymes in the ubiquitin system. Science (New York, N.Y.). 339: 590-5. PMID 23287719 DOI: 10.1126/science.1230161  1
2012 Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase Cellular Signalling. 24: 2085-2094. PMID 22796189 DOI: 10.1016/j.cellsig.2012.06.018  1
2012 Tang X, Orlicky S, Mittag T, Csizmok V, Pawson T, Forman-Kay JD, Sicheri F, Tyers M. Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCF Cdc4 ubiquitin ligase Proceedings of the National Academy of Sciences of the United States of America. 109: 3287-3292. PMID 22328159 DOI: 10.1073/pnas.1116455109  1
2012 Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, et al. OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Molecular Cell. 45: 384-97. PMID 22325355 DOI: 10.1016/j.molcel.2012.01.011  1
2012 Liu J, Fairn GD, Ceccarelli DF, Sicheri F, Wilde A. Cleavage furrow organization requires PIP 2-mediated recruitment of anillin Current Biology. 22: 64-69. PMID 22197245 DOI: 10.1016/j.cub.2011.11.040  1
2012 Chou YC, Keszei AFA, Rohde JR, Tyers M, Sicheri F. Conserved structural mechanisms for autoinhibition in IpaH ubiquitin ligases Journal of Biological Chemistry. 287: 268-275. PMID 22065585 DOI: 10.1074/jbc.M111.316265  1
2012 Ogunjimi AA, Zeqiraj E, Ceccarelli DF, Sicheri F, Wrana JL, David L. Structural basis for specificity of TGFβ family receptor small molecule inhibitors Cellular Signalling. 24: 476-483. PMID 21983015 DOI: 10.1016/j.cellsig.2011.09.027  1
2012 Juang YC, Landry MC, Sanches M, Vittal V, Leung C, Ceccarelli DF, Mateo ARF, Pruneda JN, Mao D, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, et al. OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function Molecular Cell. 46: 549. DOI: 10.1016/j.molcel.2012.05.013  1
2011 Guettler S, LaRose J, Petsalaki E, Gish G, Scotter A, Pawson T, Rottapel R, Sicheri F. Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell. 147: 1340-54. PMID 22153077 DOI: 10.1016/j.cell.2011.10.046  1
2011 Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, Dirks P, Ciruna B, Rotin D. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. The Embo Journal. 30: 3259-73. PMID 21765395 DOI: 10.1038/emboj.2011.234  1
2011 Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, ... ... Sicheri F, et al. An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell. 145: 1075-87. PMID 21683433 DOI: 10.1016/j.cell.2011.05.039  1
2011 Ceccarelli DF, Laister RC, Mulligan VK, Kean MJ, Goudreault M, Scott IC, Derry WB, Chakrabartty A, Gingras AC, Sicheri F. CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. The Journal of Biological Chemistry. 286: 25056-64. PMID 21561863 DOI: 10.1074/jbc.M110.213777  1
2011 Kean MJ, Ceccarelli DF, Goudreault M, Sanches M, Tate S, Larsen B, Gibson LC, Derry WB, Scott IC, Pelletier L, Baillie GS, Sicheri F, Gingras AC. Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. The Journal of Biological Chemistry. 286: 25065-75. PMID 21561862 DOI: 10.1074/jbc.M110.214486  1
2011 Sicheri F, Silverman RH. Putting the brakes on the unfolded protein response Journal of Cell Biology. 193: 17-19. PMID 21444688 DOI: 10.1083/jcb.201101105  1
2011 Dey M, Velyvis A, Li JJ, Chiu E, Chiovitti D, Kay LE, Sicheri F, Dever TE. Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51. Proceedings of the National Academy of Sciences of the United States of America. 108: 4316-21. PMID 21368187 DOI: 10.1073/pnas.1014872108  1
2011 Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, ... Sicheri F, et al. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease Journal of Biological Chemistry. 286: 12743-12755. PMID 21303903 DOI: 10.1074/jbc.M110.199737  1
2011 Lee KPK, Sicheri F. Principles of IRE1 modulation using chemical tools Methods in Enzymology. 490: 271-294. PMID 21266256 DOI: 10.1016/B978-0-12-385114-7.00016-7  1
2011 Liu Q, Larsen B, Ricicova M, Orlicky S, Tekotte H, Tang X, Craig K, Quiring A, Le Bihan T, Hansen C, Sicheri F, Tyers M. SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor Molecular and Cellular Biology. 31: 584-598. PMID 21098119 DOI: 10.1128/MCB.00845-10  1
2011 Udell CM, Rajakulendran T, Sicheri F, Therrien M. Mechanistic principles of RAF kinase signaling. Cellular and Molecular Life Sciences : Cmls. 68: 553-65. PMID 20820846 DOI: 10.1007/s00018-010-0520-6  1
2010 Nakada S, Tai I, Panier S, Al-Hakim A, Iemura SI, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 Nature. 466: 941-946. PMID 20725033 DOI: 10.1038/nature09297  1
2010 Youn JY, Friesen H, Kishimoto T, Henne WM, Kurat CF, Ye W, Ceccarelli DF, Sicheri F, Kohlwein SD, McMahon HT, Andrews BJ. Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis. Molecular Biology of the Cell. 21: 3054-69. PMID 20610658 DOI: 10.1091/mbc.E10-03-0181  1
2010 Orlicky S, Tang X, Neduva V, Elowe N, Brown ED, Sicheri F, Tyers M. An allosteric inhibitor of substrate recognition by the SCF Cdc4 ubiquitin ligase Nature Biotechnology. 28: 733-737. PMID 20581844 DOI: 10.1038/nbt.1646  1
2010 Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. 38: 291-304. PMID 20417606 DOI: 10.1016/j.molcel.2010.04.001  1
2010 Mittag T, Marsh J, Grishaev A, Orlicky S, Lin H, Sicheri F, Tyers M, Forman-Kay JD. Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase Structure. 18: 494-506. PMID 20399186 DOI: 10.1016/j.str.2010.01.020  1
2010 Rajakulendran T, Sicheri F. Allosteric Protein kinase regulation by pseudokinases: Insights from STRAD Science Signaling. 3: pe8. PMID 20197543 DOI: 10.1126/scisignal.3111pe8  1
2010 Ogunjimi AA, Wiesner S, Briant DJ, Varelas X, Sicheri F, Forman-Kay J, Wrana JL. The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. The Journal of Biological Chemistry. 285: 6308-15. PMID 20026602 DOI: 10.1074/jbc.M109.044537  1
2009 Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M. A dimerization-dependent mechanism drives RAF catalytic activation. Nature. 461: 542-5. PMID 19727074 DOI: 10.1038/nature08314  1
2009 Murphy JM, Hansen DF, Wiesner S, Muhandiram DR, Borg M, Smith MJ, Sicheri F, Kay LE, Forman-Kay JD, Pawson T. Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays. Journal of Molecular Biology. 393: 409-24. PMID 19715701 DOI: 10.1016/j.jmb.2009.08.049  1
2009 Ceccarelli DFJ, Sicheri F. Grb-ing hold of insulin signaling Nature Structural and Molecular Biology. 16: 803-804. PMID 19654617 DOI: 10.1038/nsmb0809-803  1
2009 Leung GC, Murphy JM, Briant D, Sicheri F. Characterization of kinase target phosphorylation consensus motifs using peptide SPOT arrays. Methods in Molecular Biology (Clifton, N.J.). 570: 187-95. PMID 19649593 DOI: 10.1007/978-1-60327-394-7_7  1
2009 Briant DJ, Murphy JM, Leung GC, Sicheri F. Rapid identification of linear protein domain binding motifs using peptide SPOT arrays. Methods in Molecular Biology (Clifton, N.J.). 570: 175-85. PMID 19649592 DOI: 10.1007/978-1-60327-394-7_6  1
2009 Meyer-Schaller N, Chou YC, Sumara I, Martin DDO, Kurz T, Katheder N, Hofmann K, Berthiaume LG, Sicheri F, Peter M. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes Proceedings of the National Academy of Sciences of the United States of America. 106: 12365-12370. PMID 19617556 DOI: 10.1073/pnas.0812528106  1
2009 Dev K, Santangelo TJ, Rothenburg S, Neculai D, Dey M, Sicheri F, Dever TE, Reeve JN, Hinnebusch AG. Archaeal aIF2B Interacts with Eukaryotic Translation Initiation Factors eIF2α and eIF2Bα: Implications for aIF2B Function and eIF2B Regulation Journal of Molecular Biology. 392: 701-722. PMID 19616556 DOI: 10.1016/j.jmb.2009.07.030  1
2009 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Molecular & Cellular Proteomics : McP. 8: 157-71. PMID 18782753 DOI: 10.1074/mcp.M800266-MCP200  1
2008 Mittag T, Orlicky S, Choy WY, Tang X, Lin H, Sicheri F, Kay LE, Tyers M, Forman-Kay JD. Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor. Proceedings of the National Academy of Sciences of the United States of America. 105: 17772-7. PMID 19008353 DOI: 10.1073/pnas.0809222105  1
2008 Seo EJ, Liu F, Kawagishi-Kobayashi M, Ung TL, Cao C, Dar AC, Sicheri F, Dever TE. Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proceedings of the National Academy of Sciences of the United States of America. 105: 16894-9. PMID 18971339 DOI: 10.1073/pnas.0805524105  1
2008 Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, ... ... Sicheri F, et al. Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Molecular Cell. 32: 259-75. PMID 18951093 DOI: 10.1016/j.molcel.2008.10.002  1
2008 Mao DY, Ceccarelli DF, Sicheri F. "Unraveling the tail" of how SRPK1 phosphorylates ASF/SF2. Molecular Cell. 29: 535-7. PMID 18342599 DOI: 10.1016/j.molcel.2008.02.009  1
2008 Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F. CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 105: 2836-41. PMID 18287031 DOI: 10.1073/pnas.0709705105  1
2008 Kurz T, Chou YC, Willems AR, Meyer-Schaller N, Hecht ML, Tyers M, Peter M, Sicheri F. Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation Molecular Cell. 29: 23-35. PMID 18206966 DOI: 10.1016/j.molcel.2007.12.012  1
2008 Lee KPK, Dey M, Neculai D, Cao C, Dever TE, Sicheri F. Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing Cell. 132: 89-100. PMID 18191223 DOI: 10.1016/j.cell.2007.10.057  1
2007 Murphy JM, Korzhnev DM, Ceccarelli DF, Briant DJ, Zarrine-Afsar A, Sicheri F, Kay LE, Pawson T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. Proceedings of the National Academy of Sciences of the United States of America. 104: 14336-41. PMID 17726107 DOI: 10.1073/pnas.0703012104  1
2007 Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell. 130: 651-62. PMID 17719543 DOI: 10.1016/j.cell.2007.06.050  1
2007 Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M. Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination Cell. 129: 1165-1176. PMID 17574027 DOI: 10.1016/j.cell.2007.04.042  1
2007 Ceccarelli DFJ, Blasutig IM, Goudreault M, Li Z, Ruston J, Pawson T, Sicheri F. Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9 Journal of Biological Chemistry. 282: 13864-13874. PMID 17339315 DOI: 10.1074/jbc.M700505200  1
2007 Dey M, Cao C, Sicheri F, Dever TE. Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK Journal of Biological Chemistry. 282: 6653-6660. PMID 17202131 DOI: 10.1074/jbc.M607897200  1
2007 Leung GC, Ho CS, Blasutig IM, Murphy JM, Sicheri F. Determination of the Plk4/Sak consensus phosphorylation motif using peptide spots arrays. Febs Letters. 581: 77-83. PMID 17174311 DOI: 10.1016/j.febslet.2006.11.080  1
2006 Wiesner S, Wybenga-Groot LE, Warner N, Lin H, Pawson T, Forman-Kay JD, Sicheri F. A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. The Embo Journal. 25: 4686-96. PMID 16977320 DOI: 10.1038/sj.emboj.7601315  1
2006 Mrkobrada S, Boucher L, Ceccarelli DF, Tyers M, Sicheri F. Structural and functional analysis of Saccharomyces cerevisiae Mob1. Journal of Molecular Biology. 362: 430-40. PMID 16934835 DOI: 10.1016/j.jmb.2006.07.007  1
2006 Briant DJ, Ceccarelli DF, Sicheri F. I Siah Substrate! Structure. 14: 627-628. PMID 16615900 DOI: 10.1016/j.str.2006.03.003  1
2006 Aviv T, Lin Z, Ben-Ari G, Smibert CA, Sicheri F. Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p Nature Structural and Molecular Biology. 13: 168-176. PMID 16429151 DOI: 10.1038/nsmb1053  1
2006 Aviv T, Amborski AN, Zhao XS, Kwan JJ, Johnson PE, Sicheri F, Donaldson LW. The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpins. Journal of Molecular Biology. 356: 274-9. PMID 16375924 DOI: 10.1016/j.jmb.2005.11.066  1
2005 Tang X, Orlicky S, Liu Q, Willems A, Sicheri F, Tyers M. Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases Methods in Enzymology. 399: 433-458. PMID 16338374 DOI: 10.1016/S0076-6879(05)99030-7  1
2005 Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE. Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell. 122: 901-13. PMID 16179259 DOI: 10.1016/j.cell.2005.06.041  1
2005 Dar AC, Dever TE, Sicheri F. Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell. 122: 887-900. PMID 16179258 DOI: 10.1016/j.cell.2005.06.044  1
2005 Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain Molecular Cell. 19: 297-308. PMID 16061177 DOI: 10.1016/j.molcel.2005.06.028  1
2005 Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, ... ... Sicheri F, et al. Problems with co-funding in Canada. Science (New York, N.Y.). 308: 1867. PMID 15976286 DOI: 10.1126/science.308.5730.1867b  1
2005 Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F, Dever TE. PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Molecular and Cellular Biology. 25: 3063-75. PMID 15798194 DOI: 10.1128/MCB.25.8.3063-3075.2005  1
2003 Hoang QQ, Sicheri F, Howard AJ, Yang DSC. Bone recognition mechanism of porcine osteocalcin from crystal structure Nature. 425: 977-980. PMID 14586470 DOI: 10.1038/nature02079  1
2003 Zigmond SH, Evangelista M, Boone C, Yang C, Dar AC, Sicheri F, Forkey J, Pring M. Formin leaky cap allows elongation in the presence of tight capping proteins. Current Biology : Cb. 13: 1820-3. PMID 14561409  1
2003 Leung GC, Sicheri F. A polo match for Plk1 Cell. 115: 3-4. PMID 14531994 DOI: 10.1016/S0092-8674(03)00761-X  1
2003 Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F, Smibert CA. The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators Nature Structural Biology. 10: 614-621. PMID 12858164 DOI: 10.1038/nsb956  1
2003 Orlicky S, Tang X, Willems A, Tyers M, Sicheri F. Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase Cell. 112: 243-256. PMID 12553912 DOI: 10.1016/S0092-8674(03)00034-5  1
2002 Leung GC, Hudson JW, Kozarova A, Davidson A, Dennis JW, Sicheri F. The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization Nature Structural Biology. 9: 719-724. PMID 12352953 DOI: 10.1038/nsb848  1
2002 Dar AC, Sicheri F. X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition. Molecular Cell. 10: 295-305. PMID 12191475  1
2001 Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature. 414: 514-21. PMID 11734846 DOI: 10.1038/35107009  1
2001 Luo Y, Bertero MG, Frey EA, Pfuetzner RA, Wenk MR, Creagh L, Marcus SL, Lim D, Sicheri F, Kay C, Haynes C, Finlay BB, Strynadka NC. Structural and biochemical characterization of the type III secretion chaperones CesT and SigE. Nature Structural Biology. 8: 1031-6. PMID 11685226 DOI: 10.1038/nsb717  1
2001 Ashman K, Moran MF, Sicheri F, Pawson T, Tyers M. Cell signalling - the proteomics of it all. Science's Stke : Signal Transduction Knowledge Environment. 2001: PE33. PMID 11593049  1
2001 Wybenga-Groot LE, Baskin B, Ong SH, Tong J, Pawson T, Sicheri F. Structural basis for autoinhibition of the EphB2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region Cell. 106: 745-757. PMID 11572780 DOI: 10.1016/S0092-8674(01)00496-2  1
2001 Ezelle HJ, Balachandran S, Sicheri F, Polyak SJ, Barber GN. Analyzing the mechanisms of interferon-induced apoptosis using CrmA and hepatitis C virus NS5A Virology. 281: 124-137. PMID 11222103 DOI: 10.1006/viro.2001.0815  1
2000 Binns KL, Taylor PP, Sicheri F, Pawson T, Holland SJ. Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors Molecular and Cellular Biology. 20: 4791-4805. PMID 10848605 DOI: 10.1128/MCB.20.13.4791-4805.2000  1
1999 Schindler T, Sicheri F, Pico A, Gazit A, Levitzki A, Kuriyan J. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor Molecular Cell. 3: 639-648. PMID 10360180 DOI: 10.1016/S1097-2765(00)80357-3  1
1999 Stapleton D, Balan I, Pawson T, Sicheri F. The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization Nature Structural Biology. 6: 44-49. PMID 9886291 DOI: 10.1038/4917  1
1999 Lafevre-Bernt M, Sicheri F, Pico A, Porter M, Kuriyan J, Todd Miller W. Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue Journal of Biological Chemistry. 273: 32129-32134. PMID 9822689 DOI: 10.1074/jbc.273.48.32129  1
1998 Yang DSC, Hon WC, Bubanko S, Xue Y, Seetharaman J, Hew CL, Sicheri F. Identification of the ice-binding surface on a type III antifreeze protein with a 'flatness function' algorithm Biophysical Journal. 74: 2142-2151. PMID 9591641  1
1997 Sicheri F, Kuriyan J. Structures of Src-family tyrosine kinases Current Opinion in Structural Biology. 7: 777-785. PMID 9434895 DOI: 10.1016/S0959-440X(97)80146-7  1
1997 Asante-Appiah E, Seetharaman J, Sicheri F, Yang DSC, Chan WWC. gem-Dialkyl succinic acids: A novel class of inhibitors for carboxypeptidases Biochemistry. 36: 8710-8715. PMID 9220957 DOI: 10.1021/bi970354b  1
1997 Moarefi I, LaFevre-Bernt M, Sicheri F, Huse M, Lee CH, Kuriyan J, Miller WT. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement Nature. 385: 650-653. PMID 9024665 DOI: 10.1038/385650a0  1
1997 Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck Nature. 385: 602-609. PMID 9024658 DOI: 10.1038/385602a0  1
1997 Kuriyan J, Moarefi L, Sicheri F, Lee CH, Huse M. Structure and regulation of sre-family tyrosine kinases Faseb Journal. 11: A875.  1
1996 Sicheri F, Yang DS. Structure determination of a lone alpha-helical antifreeze protein from winter flounder. Acta Crystallographica. Section D, Biological Crystallography. 52: 486-98. PMID 15299670 DOI: 10.1107/S0907444995015253  0.96
1996 Sicheri F, Yang DSC. Structure determination of a lone α-helical antifreeze protein from winter flounder Acta Crystallographica Section D: Biological Crystallography. 52: 486-498.  1
1995 Sicheri F, Yang DSC. Ice-binding structure and mechanism of an antifreeze protein from winter flounder Nature. 375: 427-431. PMID 7760940  1
1994 Xue YQ, Sicheri F, Ala P, Hew CL, Yang DSC. Single crystals of a type III antifreeze polypeptide from ocean pout Journal of Molecular Biology. 237: 351-352. PMID 8145247 DOI: 10.1006/jmbi.1994.1236  1
1991 Sicheri FV, Derry WB, Gupta RS, Yang DSC. Structure of 4'‐demethyl‐9‐(3''‐thymidyl)‐epipodophyllotoxin Acta Crystallographica Section C. 47: 2479-2482. DOI: 10.1107/S0108270191005140  1
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