Ben Shen, Ph.D. - Publications

Affiliations: 
Chemistry Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Natural Product Biosynthesis

216 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liang H, Jiang L, Jiang Q, Shi J, Xiang J, Yan X, Zhu X, Zhao L, Shen B, Duan Y, Huang Y. A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the discovery of the acyltransferase-less type I polyketide synthases. Environmental Microbiology. PMID 31435987 DOI: 10.1111/1462-2920.14787  0.96
2019 Dong LB, Liu YC, Cepeda AJ, Kalkreuter E, Deng MR, Rudolf JD, Chang C, Joachimiak A, Phillips GN, Shen B. Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. PMID 31291107 DOI: 10.1021/jacs.9b06183  0.96
2019 Deng Y, Weng X, Li Y, Su M, Wen Z, Ji X, Ren N, Shen B, Duan Y, Huang Y. Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo. Journal of Medicinal Chemistry. PMID 31265289 DOI: 10.1021/acs.jmedchem.9b00616  0.96
2019 Su M, Qiu L, Deng Y, Ruiz CH, Rudolf JD, Dong LB, Feng X, Cameron MD, Shen B, Duan Y, Huang Y. Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models. Molecular Pharmaceutics. PMID 31244223 DOI: 10.1021/acs.molpharmaceut.9b00293  0.96
2019 Xu Z, Fang SM, Bakowski MA, Rateb ME, Yang D, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Hull MV, McNamara CW, Shen B. Discovery of Kirromycins with Anti- Wolbachia Activity from Streptomyces sp. CB00686. Acs Chemical Biology. PMID 31074963 DOI: 10.1021/acschembio.9b00086  0.96
2019 Qiu L, Wen Z, Li Y, Tian K, Deng Y, Shen B, Duan Y, Huang Y. Stereoselective functionalization of platensimycin and platencin by sulfa-Michael/aldol reactions. Organic & Biomolecular Chemistry. PMID 30816397 DOI: 10.1039/c9ob00324j  0.96
2019 Dong LB, Zhang X, Shen B, Rudolf JD, Deng MR, Kalkreuter E, Cepeda AJ, Renata H. Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. PMID 30735041 DOI: 10.1021/jacs.8b13452  0.96
2018 Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Shen B, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/acscentsci.8b00747  0.48
2018 Xu Z, Pan G, Zhou H, Shen B. Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin. Journal of the American Chemical Society. PMID 30472830 DOI: 10.1021/jacs.8b11463  0.52
2018 McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, ... ... Shen B, et al. Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports. PMID 30468235 DOI: 10.1039/c8np90041h  0.52
2018 Deng Y, Su M, Kang D, Liu X, Wen Z, Li Y, Qiu L, Shen B, Duan Y, Huang Y. Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. Journal of Medicinal Chemistry. PMID 30461269 DOI: 10.1021/acs.jmedchem.8b01580  0.96
2018 Rudolf JD, Dong LB, Zhang X, Renata H, Shen B. Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis. Journal of the American Chemical Society. PMID 30216060 DOI: 10.1021/jacs.8b08012  0.96
2018 Yan X, Chen JJ, Adhikari A, Teijaro CN, Ge H, Crnovcic I, Chang CY, Annaval T, Yang D, Rader C, Shen B. Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis. Organic Letters. PMID 30212211 DOI: 10.1021/acs.orglett.8b02584  0.68
2018 Annaval T, Han L, Rudolf JD, Xie G, Yang D, Chang CY, Ma M, Crnovcic I, Miller MD, Soman J, Xu W, Phillips GN, Shen B. Biochemical and structural characterization of TtnD, a prenylated FMN-dependent decarboxylase from the tautomycetin biosynthetic pathway. Acs Chemical Biology. PMID 30152678 DOI: 10.1021/acschembio.8b00673  0.96
2018 Deng Y, Kang D, Shi J, Zhou W, Sun A, Ju J, Zhu X, Shen B, Duan Y, Huang Y. The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. Medchemcomm. 9: 789-794. PMID 30108968 DOI: 10.1039/c8md00081f  0.96
2018 Kwong T, Ma M, Pan G, Hindra, Yang D, Yang C, Lohman JR, Rudolf JD, Cleveland JL, Shen B. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. Biochemistry. PMID 30070831 DOI: 10.1021/acs.biochem.8b00623  0.96
2018 Jiang L, Pu H, Xiang J, Su M, Yan X, Yang D, Zhu X, Shen B, Duan Y, Huang Y. Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From sp. CB09001. Frontiers in Chemistry. 6: 254. PMID 30013965 DOI: 10.3389/fchem.2018.00254  0.96
2018 Murray V, Chen JK, Yang D, Shen B. The genome-wide sequence specificity of DNA cleavage by bleomycin analogues in human cells. Bioorganic & Medicinal Chemistry. PMID 30006142 DOI: 10.1016/j.bmc.2018.07.006  0.6
2018 McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, ... ... Shen B, et al. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports. PMID 30003207 DOI: 10.1039/c7np00064b  0.52
2018 Chang CY, Yan X, Crnovcic I, Annaval T, Chang C, Nocek B, Rudolf JD, Yang D, Hindra, Babnigg G, Joachimiak A, Phillips GN, Shen B. Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chemical Biology. PMID 29937405 DOI: 10.1016/j.chembiol.2018.05.012  0.96
2018 Dong LB, Rudolf JD, Kang D, Wang N, He CQ, Deng Y, Huang Y, Houk KN, Duan Y, Shen B. Biosynthesis of thiocarboxylic acid-containing natural products. Nature Communications. 9: 2362. PMID 29915173 DOI: 10.1038/s41467-018-04747-y  0.96
2018 Kong J, Yi L, Xiong Y, Huang Y, Yang D, Yan X, Shen B, Duan Y, Zhu X. The discovery and development of microbial bleomycin analogues. Applied Microbiology and Biotechnology. PMID 29876605 DOI: 10.1007/s00253-018-9129-8  0.96
2018 Wang N, Rudolf JD, Dong LB, Osipiuk J, Hatzos-Skintges C, Endres M, Chang CY, Babnigg G, Joachimiak A, Phillips GN, Shen B. Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nature Chemical Biology. PMID 29867143 DOI: 10.1038/s41589-018-0061-0  0.96
2018 Shen B, Dong LB, Rudolf JD, Deng MR, Yan X. Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases. Chembiochem : a European Journal of Chemical Biology. PMID 29806086 DOI: 10.1002/cbic.201800285  0.96
2018 Crnovcic I, Gan F, Yang D, Dong LB, Schultz PG, Shen B. Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity. Bioorganic & Medicinal Chemistry Letters. PMID 29730026 DOI: 10.1016/j.bmcl.2018.04.065  0.96
2018 Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structural Insights into the Free-standing Condensation Enzyme SgcC5 Catalyzing Ester Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027. Biochemistry. PMID 29533601 DOI: 10.1021/acs.biochem.8b00174  0.96
2018 Chen JJ, Rateb ME, Love MS, Xu Z, Yang D, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, McNamara CW, Shen B. Herbicidins from Streptomyces sp. CB01388 Showing Anti-Cryptosporidium Activity. Journal of Natural Products. PMID 29469575 DOI: 10.1021/acs.jnatprod.7b00850  0.96
2018 Liu L, Pan J, Wang Z, Yan X, Yang D, Zhu X, Shen B, Duan Y, Huang Y. Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234. Journal of Industrial Microbiology & Biotechnology. PMID 29396746 DOI: 10.1007/s10295-018-2014-8  0.96
2018 Qiu L, Tian K, Wen Z, Deng Y, Kang D, Liang H, Zhu X, Shen B, Duan Y, Huang Y. Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. Journal of Natural Products. PMID 29389125 DOI: 10.1021/acs.jnatprod.7b00745  0.96
2018 Yan X, Hindra, Ge H, Yang D, Huang T, Crnovcic I, Chang CY, Fang SM, Annaval T, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers. Journal of Natural Products. PMID 29345939 DOI: 10.1021/acs.jnatprod.7b01013  0.96
2018 Guo X, Crnovcic I, Chang CY, Luo J, Lohman JR, Papinski M, Bechthold A, Horsman GP, Shen B. PokMT1 from the polyketomycin biosynthetic machinery of Streptomyces diastatochromogenes Tü6028 belongs to the emerging family of C-methyltransferases that act on CoA-activated aromatic substrates. Biochemistry. PMID 29341603 DOI: 10.1021/acs.biochem.7b01219  0.96
2017 Zhu X, Kong J, Yang H, Huang R, Huang Y, Yang D, Shen B, Duan Y. Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6'-deoxy-bleomycin Z production. Applied Microbiology and Biotechnology. PMID 29279956 DOI: 10.1007/s00253-017-8705-7  0.96
2017 Imani Nejad M, Yang D, Shen B, Gates KS. Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA. Chemical Communications (Cambridge, England). PMID 29231931 DOI: 10.1039/c7cc08482j  0.6
2017 Pan G, Xu Z, Guo Z, Hindra, Ma M, Yang D, Zhou H, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, Cheng J, Van Nieuwerburgh F, Suh JW, ... ... Shen B, et al. Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proceedings of the National Academy of Sciences of the United States of America. PMID 29229819 DOI: 10.1073/pnas.1716245115  0.96
2017 Yan X, Chen JJ, Adhikari A, Yang D, Crnovcic I, Wang N, Chang CY, Rader C, Shen B. Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne. Organic Letters. PMID 29086572 DOI: 10.1021/acs.orglett.7b03120  0.68
2017 Annaval T, Rudolf JD, Chang CY, Lohman JR, Kim Y, Bigelow L, Jedrzejczak R, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis. Acs Omega. 2: 5159-5169. PMID 28884166 DOI: 10.1021/acsomega.7b00933  0.96
2017 Yang D, Hindra, Dong LB, Crnovcic I, Shen B. Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin. The Journal of Antibiotics. PMID 28831149 DOI: 10.1038/ja.2017.93  0.96
2017 Rudolf JD, Chang CY, Ma M, Shen B. Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Natural Product Reports. PMID 28758170 DOI: 10.1039/c7np00034k  0.96
2017 Qiu L, Tian K, Pan J, Jiang L, Yang H, Zhu X, Shen B, Duan Y, Huang Y. A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin. Tetrahedron. 73: 771-775. PMID 28626267 DOI: 10.1016/j.tet.2016.12.059  0.96
2017 Falzone M, Crespo E, Jones K, Khan G, Korn VL, Patel A, Patel M, Patel K, Perkins C, Siddiqui S, Stenger D, Yu E, Gelber M, Scheffler R, Nayda V, ... ... Shen B, et al. Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid. The Journal of Antibiotics. PMID 28465627 DOI: 10.1038/ja.2017.49  0.96
2017 Shen B, Zhang B, Xu Z, Teng Q, Pan G, Ma M. A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis. Angewandte Chemie (International Ed. in English). PMID 28464455 DOI: 10.1002/anie.201703588  0.64
2017 Hindra, Yang D, Teng Q, Dong LB, Crnovčić I, Huang T, Ge H, Shen B. Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues. Organic Letters. PMID 28256838 DOI: 10.1021/acs.orglett.7b00283  0.96
2017 Dong LB, Rudolf JD, Lin L, Ruiz C, Cameron MD, Shen B. In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin. Bioorganic & Medicinal Chemistry. PMID 28237556 DOI: 10.1016/j.bmc.2017.02.028  0.96
2017 Yang D, Rateb ME, Wang N, Shen B. Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D. The Journal of Antibiotics. PMID 28196980 DOI: 10.1038/ja.2017.13  0.6
2017 Chen JK, Yang D, Shen B, Murray V. Bleomycin analogues preferentially cleave at the transcription start sites of actively transcribed genes in human cells. The International Journal of Biochemistry & Cell Biology. PMID 28167289 DOI: 10.1016/j.biocel.2017.02.001  0.6
2016 Yan X, Ge H, Huang T, Hindra, Yang D, Teng Q, Crnovčić I, Li X, Rudolf JD, Lohman JR, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, ... ... Shen B, et al. Strain Prioritization and Genome Mining for Enediyne Natural Products. Mbio. 7. PMID 27999165 DOI: 10.1128/mBio.02104-16  0.96
2016 Rudolf JD, Dong LB, Manoogian K, Shen B. Biosynthetic Origin of the Ether Ring in Platensimycin. Journal of the American Chemical Society. PMID 27966343 DOI: 10.1021/jacs.6b09818  0.96
2016 Rudolf JD, Dong LB, Shen B. Platensimycin and Platencin: Inspirations for Chemistry, Biology, Enzymology, and Medicine. Biochemical Pharmacology. PMID 27865713 DOI: 10.1016/j.bcp.2016.11.013  0.96
2016 Chen JK, Yang D, Shen B, Neilan BA, Murray V. Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues. Bioorganic & Medicinal Chemistry. PMID 27745992 DOI: 10.1016/j.bmc.2016.09.072  0.6
2016 Guo Z, Pan G, Xu Z, Yang D, Hindra, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883. The Journal of Antibiotics. PMID 27731333 DOI: 10.1038/ja.2016.122  0.96
2016 Huang Y, Yang D, Pan G, Tang GL, Shen B. Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement. Applied Microbiology and Biotechnology. PMID 27704182 DOI: 10.1007/s00253-016-7864-2  0.96
2016 Dong LB, Rudolf JD, Shen B. A Mutasynthetic Library of Platensimycin and Platencin Analogues. Organic Letters. PMID 27599271 DOI: 10.1021/acs.orglett.6b02248  1
2016 Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN, Shen B. Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase that Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate in Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry. PMID 27560143 DOI: 10.1021/acs.biochem.6b00713  1
2016 Huang Y, Tang GL, Pan G, Chang CY, Shen B. Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis. Organic Letters. PMID 27541042 DOI: 10.1021/acs.orglett.6b02033  1
2016 Ma M, Rateb ME, Yang D, Rudolf JD, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Germicidins H-J from Streptomyces sp. CB00361. The Journal of Antibiotics. PMID 27507632 DOI: 10.1038/ja.2016.100  0.96
2016 Rudolf JD, Dong LB, Cao H, Hatzos-Skintges C, Osipiuk J, Endres M, Chang CY, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase. Journal of the American Chemical Society. PMID 27490479 DOI: 10.1021/jacs.6b04317  1
2016 Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, ... ... Shen B, et al. Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. The Journal of Antibiotics. PMID 27406907 DOI: 10.1038/ja.2016.88  0.96
2016 Dong LB, Rudolf JD, Shen B. Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029. Bioorganic & Medicinal Chemistry. PMID 27134119 DOI: 10.1016/j.bmc.2016.04.026  1
2016 Shi J, Pan J, Liu L, Yang D, Lu S, Zhu X, Shen B, Duan Y, Huang Y. Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026. Journal of Industrial Microbiology & Biotechnology. PMID 27126098 DOI: 10.1007/s10295-016-1769-z  1
2016 Li W, Li X, Huang T, Teng Q, Crnovcic I, Rader C, Shen B. Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluation. Bioorganic & Medicinal Chemistry. PMID 27094150 DOI: 10.1016/j.bmc.2016.04.017  0.68
2016 Smanski MJ, Zhou H, Claesen J, Shen B, Fischbach MA, Voigt CA. Synthetic biology to access and expand nature's chemical diversity. Nature Reviews. Microbiology. 14: 135-49. PMID 26876034 DOI: 10.1038/nrmicro.2015.24  0.64
2015 Shen B. A New Golden Age of Natural Products Drug Discovery. Cell. 163: 1297-300. PMID 26638061 DOI: 10.1016/j.cell.2015.11.031  1
2015 Zhang B, Yang D, Yan Y, Pan G, Xiang W, Shen B. Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins. Applied Microbiology and Biotechnology. PMID 26552797 DOI: 10.1007/s00253-015-7119-7  1
2015 Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. Biochemistry. PMID 26512730 DOI: 10.1021/acs.biochem.5b01008  1
2015 Lohman JR, Ma M, Osipiuk J, Nocek B, Kim Y, Chang C, Cuff M, Mack J, Bigelow L, Li H, Endres M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26420866 DOI: 10.1073/pnas.1515460112  1
2015 Ma M, Rateb ME, Teng Q, Yang D, Rudolf JD, Zhu X, Huang Y, Zhao LX, Jiang Y, Li X, Rader C, Duan Y, Shen B. Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion. Journal of Natural Products. PMID 26335269 DOI: 10.1021/acs.jnatprod.5b00601  1
2015 Rudolf JD, Yan X, Shen B. Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery. Journal of Industrial Microbiology & Biotechnology. PMID 26318027 DOI: 10.1007/s10295-015-1671-0  1
2015 Ma M, Lohman JR, Liu T, Shen B. C-S bond cleavage by a polyketide synthase domain. Proceedings of the National Academy of Sciences of the United States of America. 112: 10359-64. PMID 26240335 DOI: 10.1073/pnas.1508437112  1
2015 Liu T, Ma M, Ge HM, Yang C, Cleveland J, Shen B. Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin. Bioorganic & Medicinal Chemistry Letters. PMID 26071634 DOI: 10.1016/j.bmcl.2015.05.078  1
2015 Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, Lohman JR, Tang GL, Ju J, Liu T, Wilding G, Shen B. Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America. 112: 8278-83. PMID 26056295 DOI: 10.1073/pnas.1506761112  1
2015 Rudolf JD, Dong LB, Huang T, Shen B. A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase. Molecular Biosystems. PMID 26055255 DOI: 10.1039/c5mb00303b  1
2015 Yang Z, Cao S, Martens CA, Porcella SF, Xie Z, Ma M, Shen B, Moss B. Deciphering poxvirus gene expression by RNA sequencing and ribosome profiling. Journal of Virology. 89: 6874-86. PMID 25903347 DOI: 10.1128/JVI.00528-15  0.64
2015 Rateb ME, Yang D, Vodanovic-Jankovic S, Yu Z, Kron MA, Shen B. Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites. The Journal of Antibiotics. PMID 25735843 DOI: 10.1038/ja.2015.22  1
2015 Gao X, Wan J, Liu B, Ma M, Shen B, Qian SB. Quantitative profiling of initiating ribosomes in vivo. Nature Methods. 12: 147-53. PMID 25486063 DOI: 10.1038/nmeth.3208  1
2015 Shen B, Hindra, Yan X, Huang T, Ge H, Yang D, Teng Q, Rudolf JD, Lohman JR. Enediynes: Exploration of microbial genomics to discover new anticancer drug leads. Bioorganic & Medicinal Chemistry Letters. 25: 9-15. PMID 25434000 DOI: 10.1016/j.bmcl.2014.11.019  1
2014 Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry. 53: 7854-65. PMID 25405956 DOI: 10.1021/bi501396v  1
2014 Coughlin JM, Rudolf JD, Wendt-Pienkowski E, Wang L, Unsin C, Galm U, Yang D, Tao M, Shen B. BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin. Biochemistry. 53: 6901-9. PMID 25299801 DOI: 10.1021/bi501121e  1
2014 Hindra, Huang T, Yang D, Rudolf JD, Xie P, Xie G, Teng Q, Lohman JR, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Strain prioritization for natural product discovery by a high-throughput real-time PCR method. Journal of Natural Products. 77: 2296-303. PMID 25238028 DOI: 10.1021/np5006168  1
2014 Koch A, Gawron D, Steyaert S, Ndah E, Crappé J, De Keulenaer S, De Meester E, Ma M, Shen B, Gevaert K, Van Criekinge W, Van Damme P, Menschaert G. A proteogenomics approach integrating proteomics and ribosome profiling increases the efficiency of protein identification and enables the discovery of alternative translation start sites. Proteomics. 14: 2688-98. PMID 25156699 DOI: 10.1002/pmic.201400180  1
2014 Lohman JR, Ma M, Cuff ME, Bigelow L, Bearden J, Babnigg G, Joachimiak A, Phillips GN, Shen B. The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins. Proteins. 82: 1210-8. PMID 25050442 DOI: 10.1002/prot.24485  1
2014 Ge HM, Huang T, Rudolf JD, Lohman JR, Huang SX, Guo X, Shen B. Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis. Organic Letters. 16: 3958-61. PMID 25019332 DOI: 10.1021/ol501767v  1
2014 Beerman TA, Gawron LS, Shen B, Kennedy DR. The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance. Dna Repair. 21: 165-70. PMID 24986640 DOI: 10.1016/j.dnarep.2014.06.001  1
2014 Yin M, Yan Y, Lohman JR, Huang SX, Ma M, Zhao GR, Xu LH, Xiang W, Shen B. Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Organic Letters. 16: 3072-5. PMID 24815182 DOI: 10.1021/ol501179w  1
2014 Peterson RM, Huang T, Rudolf JD, Smanski MJ, Shen B. Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains. Chemistry & Biology. 21: 389-97. PMID 24560608 DOI: 10.1016/j.chembiol.2014.01.005  1
2014 Xie P, Ma M, Rateb ME, Shaaban KA, Yu Z, Huang SX, Zhao LX, Zhu X, Yan Y, Peterson RM, Lohman JR, Yang D, Yin M, Rudolf JD, Jiang Y, ... ... Shen B, et al. Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. Journal of Natural Products. 77: 377-87. PMID 24484381 DOI: 10.1021/np401063s  1
2014 Rateb ME, Yu Z, Yan Y, Yang D, Huang T, Vodanovic-Jankovic S, Kron MA, Shen B. Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J. The Journal of Antibiotics. 67: 127-32. PMID 23715040 DOI: 10.1038/ja.2013.50  1
2013 Horsman GP, Lechner A, Ohnishi Y, Moore BS, Shen B. Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. Biochemistry. 52: 5217-24. PMID 23844627 DOI: 10.1021/bi400572a  1
2013 Huang SX, Lohman JR, Huang T, Shen B. A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America. 110: 8069-74. PMID 23633564 DOI: 10.1073/pnas.1304733110  1
2013 Ma M, Kwong T, Lim SK, Ju J, Lohman JR, Shen B. Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity. Journal of the American Chemical Society. 135: 2489-92. PMID 23394593 DOI: 10.1021/ja4002635  1
2013 Yu Z, Rateb ME, Smanski MJ, Peterson RM, Shen B. Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600. The Journal of Antibiotics. 66: 291-4. PMID 23361357 DOI: 10.1038/ja.2013.1  1
2013 Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B. Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. Molecular Biosystems. 9: 478-91. PMID 23360970 DOI: 10.1039/c3mb25523a  1
2013 Lohman JR, Bingman CA, Phillips GN, Shen B. Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold. Biochemistry. 52: 902-11. PMID 23320975 DOI: 10.1021/bi301652y  1
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Shen B, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/c2np20085f  1
2013 Kurata S, Shen B, Liu JO, Takeuchi N, Kaji A, Kaji H. Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors. Nucleic Acids Research. 41: 264-76. PMID 23087377 DOI: 10.1093/nar/gks958  1
2013 Tebbets B, Yu Z, Stewart D, Zhao LX, Jiang Y, Xu LH, Andes D, Shen B, Klein B. Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. Medical Mycology. 51: 280-9. PMID 22928922 DOI: 10.3109/13693786.2012.710917  1
2012 Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman JS. Decoding human cytomegalovirus. Science (New York, N.Y.). 338: 1088-93. PMID 23180859 DOI: 10.1126/science.1227919  1
2012 Smanski MJ, Casper J, Peterson RM, Yu Z, Rajski SR, Shen B. Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners. Journal of Natural Products. 75: 2158-67. PMID 23157615 DOI: 10.1021/np3005985  1
2012 Lin S, Huang T, Shen B. Tailoring enzymes acting on carrier protein-tethered substrates in natural product biosynthesis. Methods in Enzymology. 516: 321-43. PMID 23034236 DOI: 10.1016/B978-0-12-394291-3.00008-3  1
2012 Lohman JR, Shen B. 4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis. Methods in Enzymology. 516: 299-319. PMID 23034235 DOI: 10.1016/B978-0-12-394291-3.00007-1  1
2012 Smanski MJ, Peterson RM, Shen B. Platensimycin and platencin biosynthesis in Streptomyces platensis, showcasing discovery and characterization of novel bacterial diterpene synthases. Methods in Enzymology. 515: 163-86. PMID 22999174 DOI: 10.1016/B978-0-12-394290-6.00008-2  1
2012 Yu Z, Vodanovic-Jankovic S, Kron M, Shen B. New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase Organic Letters. 14: 4946-4949. PMID 22967068 DOI: 10.1021/ol302298k  1
2012 Lee S, Liu B, Lee S, Huang SX, Shen B, Qian SB. Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Proceedings of the National Academy of Sciences of the United States of America. 109: E2424-32. PMID 22927429 DOI: 10.1073/pnas.1207846109  1
2012 Huang SX, Feng Z, Wang L, Galm U, Wendt-Pienkowski E, Yang D, Tao M, Coughlin JM, Duan Y, Shen B. A designer bleomycin with significantly improved DNA cleavage activity. Journal of the American Chemical Society. 134: 13501-9. PMID 22831455 DOI: 10.1021/ja3056535  1
2012 Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B. Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Organic Letters. 14: 2300-3. PMID 22519717 DOI: 10.1021/ol300720s  1
2012 Shen B, Thorson JS. Expanding nature's chemical repertoire through metabolic engineering and biocatalysis. Current Opinion in Chemical Biology. 16: 99-100. PMID 22464247 DOI: 10.1016/j.cbpa.2012.03.006  1
2012 Smanski MJ, Peterson RM, Huang SX, Shen B. Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis. Current Opinion in Chemical Biology. 16: 132-41. PMID 22445175 DOI: 10.1016/j.cbpa.2012.03.002  1
2012 Yang D, Li W, Huang SX, Shen B. Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. Organic Letters. 14: 1302-5. PMID 22339318 DOI: 10.1021/ol300187p  1
2012 Huang SX, Wang XJ, Yan Y, Wang JD, Zhang J, Liu CX, Xiang WS, Shen B. Neaumycin: a new macrolide from Streptomyces sp. NEAU-x211. Organic Letters. 14: 1254-7. PMID 22332843 DOI: 10.1021/ol300074d  1
2011 Zhao LX, Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, McMahon JB, Schmid T, Blees JS, Colburn NH, Rajski SR, Shen B. Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. Journal of Natural Products. 74: 1990-5. PMID 21870828 DOI: 10.1021/np200603g  1
2011 Smanski MJ, Yu Z, Casper J, Lin S, Peterson RM, Chen Y, Wendt-Pienkowski E, Rajski SR, Shen B. Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 13498-503. PMID 21825154 DOI: 10.1073/pnas.1106919108  1
2011 Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B. The missing C-17 O-methyltransferase in geldanamycin biosynthesis. Organic Letters. 13: 3726-9. PMID 21682254 DOI: 10.1021/ol201383w  1
2011 Yu Z, Vodanovic-Jankovic S, Ledeboer N, Huang SX, Rajski SR, Kron M, Shen B. Tirandamycins from streptomyces sp. 17944 inhibiting the parasite brugia malayi asparagine tRNA synthetase Organic Letters. 13: 2034-2037. PMID 21405052 DOI: 10.1021/ol200420u  1
2011 Liu S, Yu Z, Yu X, Huang SX, Luo Y, Wu L, Shen W, Yang Z, Wang L, Gunawan AM, Chan RJ, Shen B, Zhang ZY. SHP2 is a target of the immunosuppressant tautomycetin. Chemistry & Biology. 18: 101-10. PMID 21276943 DOI: 10.1016/j.chembiol.2010.10.015  1
2011 Shen B, Ikeda H. Special issue of The Journal of Antibiotics dedicated to the late Professor C Richard Hutchinson. The Journal of Antibiotics. 64: 3-5. PMID 21270810 DOI: 10.1038/ja.2010.158  1
2011 Chen Y, Yin M, Horsman GP, Shen B. Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus. Journal of Natural Products. 74: 420-4. PMID 21250756 DOI: 10.1021/np100825y  1
2011 Zhang Q, Li Y, Chen D, Yu Y, Duan L, Shen B, Liu W. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology. 7: 154-60. PMID 21240261 DOI: 10.1038/nchembio.512  1
2011 Xu K, Liu L, Saad OM, Baudys J, Williams L, Leipold D, Shen B, Raab H, Junutula JR, Kim A, Kaur S. Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry. Analytical Biochemistry. 412: 56-66. PMID 21216214 DOI: 10.1016/j.ab.2011.01.004  0.32
2011 Galm U, Wendt-Pienkowski E, Wang L, Huang SX, Unsin C, Tao M, Coughlin JM, Shen B. Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin. Journal of Natural Products. 74: 526-36. PMID 21210656 DOI: 10.1021/np1008152  1
2011 Huang Y, Huang SX, Ju J, Tang G, Liu T, Shen B. Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis. Organic Letters. 13: 498-501. PMID 21192727 DOI: 10.1021/ol102838y  1
2011 Huang SX, Yu Z, Robert F, Zhao LX, Jiang Y, Duan Y, Pelletier J, Shen B. Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141. The Journal of Antibiotics. 64: 163-6. PMID 21139626 DOI: 10.1038/ja.2010.150  1
2011 Yang D, Zhu X, Wu X, Feng Z, Huang L, Shen B, Xu Z. Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR. Applied Microbiology and Biotechnology. 89: 1709-19. PMID 21132287 DOI: 10.1007/s00253-010-3025-1  1
2011 Yu Z, Zhao LX, Jiang CL, Duan Y, Wong L, Carver KC, Schuler LA, Shen B. Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209. The Journal of Antibiotics. 64: 159-62. PMID 21102599 DOI: 10.1038/ja.2010.147  1
2010 Wu X, Yang D, Zhu X, Feng Z, Lv Z, Zhang Y, Shen B, Xu Z. Iso-migrastatin Titer Improvement in the Engineered Streptomyces lividans SB11002 Strain by Optimization of Fermentation Conditions. Biotechnology and Bioprocess Engineering : Bbe. 15: 664-669. PMID 21625393 DOI: 10.1007/s12257-009-3129-6  1
2010 Yu Y, Guo H, Zhang Q, Duan L, Ding Y, Liao R, Lei C, Shen B, Liu W. NosA catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptide. Journal of the American Chemical Society. 132: 16324-6. PMID 21047073 DOI: 10.1021/ja106571g  1
2010 Chen Y, Wendt-Pienkowski E, Ju J, Lin S, Rajski SR, Shen B. Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. The Journal of Biological Chemistry. 285: 38853-60. PMID 20926388 DOI: 10.1074/jbc.M110.147744  1
2010 Rajski SR, Shen B. Multifaceted modes of action for the glutarimide-containing polyketides revealed. Chembiochem : a European Journal of Chemical Biology. 11: 1951-4. PMID 20806307 DOI: 10.1002/cbic.201000370  1
2010 Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B. Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate. Journal of the American Chemical Society. 132: 12534-6. PMID 20718468 DOI: 10.1021/ja1050814  1
2010 Lin S, Horsman GP, Shen B. Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster. Organic Letters. 12: 3816-9. PMID 20704329 DOI: 10.1021/ol101473t  1
2010 Powell E, Huang SX, Xu Y, Rajski SR, Wang Y, Peters N, Guo S, Xu HE, Hoffmann FM, Shen B, Xu W. Identification and characterization of a novel estrogenic ligand actinopolymorphol A. Biochemical Pharmacology. 80: 1221-9. PMID 20599778 DOI: 10.1016/j.bcp.2010.06.030  1
2010 Huang SX, Powell E, Rajski SR, Zhao LX, Jiang CL, Duan Y, Xu W, Shen B. Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from Actinopolymorpha rutilus. Organic Letters. 12: 3525-7. PMID 20593804 DOI: 10.1021/ol1013526  1
2010 Chen Y, Yin M, Horsman GP, Huang S, Shen B. Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027. The Journal of Antibiotics. 63: 482-5. PMID 20551990 DOI: 10.1038/ja.2010.55  1
2010 Horsman GP, Chen Y, Thorson JS, Shen B. Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes. Proceedings of the National Academy of Sciences of the United States of America. 107: 11331-5. PMID 20534556 DOI: 10.1073/pnas.1003442107  1
2010 Luo Y, Li W, Ju J, Yuan Q, Peters NR, Hoffmann FM, Huang SX, Bugni TS, Rajski S, Osada H, Shen B. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. Journal of the American Chemical Society. 132: 6663-71. PMID 20426415 DOI: 10.1021/ja9082446  1
2010 Zhao C, Coughlin JM, Ju J, Zhu D, Wendt-Pienkowski E, Zhou X, Wang Z, Shen B, Deng Z. Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units. The Journal of Biological Chemistry. 285: 20097-108. PMID 20406823 DOI: 10.1074/jbc.M109.090092  1
2010 Yu Z, Smanski MJ, Peterson RM, Marchillo K, Andes D, Rajski SR, Shen B. Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners. Organic Letters. 12: 1744-7. PMID 20232845 DOI: 10.1021/ol100342m  1
2010 Schneider-Poetsch T, Ju J, Eyler DE, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nature Chemical Biology. 6: 209-217. PMID 20118940 DOI: 10.1038/nchembio.304  0.64
2010 Tao M, Wang L, Wendt-Pienkowski E, Zhang N, Yang D, Galm U, Coughlin JM, Xu Z, Shen B. Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog. Molecular Biosystems. 6: 349-56. PMID 20094654 DOI: 10.1039/b918106g  1
2010 Chen Y, Smanski MJ, Shen B. Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Applied Microbiology and Biotechnology. 86: 19-25. PMID 20091304 DOI: 10.1007/s00253-009-2428-3  1
2010 Zhang N, Zhu X, Yang D, Cai J, Tao M, Wang L, Duan Y, Shen B, Xu Z. Improved production of the tallysomycin H-1 in Streptoalloteichus hindustanus SB8005 strain by fermentation optimization. Applied Microbiology and Biotechnology. 86: 1345-53. PMID 20049429 DOI: 10.1007/s00253-009-2406-9  1
2009 Lin S, Horsman GP, Chen Y, Li W, Shen B. Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis. Journal of the American Chemical Society. 131: 16410-7. PMID 19856960 DOI: 10.1021/ja901242s  1
2009 Van Lanen SG, Lin S, Horsman GP, Shen B. Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027. Fems Microbiology Letters. 300: 237-41. PMID 19817865 DOI: 10.1111/j.1574-6968.2009.01802.x  1
2009 Lim SK, Ju J, Zazopoulos E, Jiang H, Seo JW, Chen Y, Feng Z, Rajski SR, Farnet CM, Shen B. iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. The Journal of Biological Chemistry. 284: 29746-56. PMID 19726666 DOI: 10.1074/jbc.M109.046805  1
2009 Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry. 48: 9590-8. PMID 19702337 DOI: 10.1021/bi901257q  1
2009 Yu Y, Duan L, Zhang Q, Liao R, Ding Y, Pan H, Wendt-Pienkowski E, Tang G, Shen B, Liu W. Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. Acs Chemical Biology. 4: 855-64. PMID 19678698 DOI: 10.1021/cb900133x  1
2009 Chen Y, Wendt-Pienkoski E, Rajski SR, Shen B. In vivo investigation of the roles of FdmM and FdmM1 in fredericamycin biosynthesis unveiling a new family of oxygenases. The Journal of Biological Chemistry. 284: 24735-43. PMID 19620242 DOI: 10.1074/jbc.M109.014191  1
2009 Liu T, Huang Y, Shen B. Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis. Journal of the American Chemical Society. 131: 6900-1. PMID 19405532 DOI: 10.1021/ja9012134  1
2009 Adler JT, Cook M, Luo Y, Pitt SC, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Molecular Cancer Therapeutics. 8: 914-20. PMID 19372564 DOI: 10.1158/1535-7163.MCT-08-0712  1
2009 Cheng YQ, Coughlin JM, Lim SK, Shen B. Type I polyketide synthases that require discrete acyltransferases. Methods in Enzymology. 459: 165-86. PMID 19362640 DOI: 10.1016/S0076-6879(09)04608-4  1
2009 Horsman GP, Van Lanen SG, Shen B. Iterative type I polyketide synthases for enediyne core biosynthesis. Methods in Enzymology. 459: 97-112. PMID 19362637 DOI: 10.1016/S0076-6879(09)04605-9  1
2009 Jiang H, Rajski SR, Shen B. Tandem acyl carrier protein domains in polyunsaturated fatty acid synthases. Methods in Enzymology. 459: 79-96. PMID 19362636 DOI: 10.1016/S0076-6879(09)04604-7  1
2009 Ju J, Li W, Yuan Q, Peters NR, Hoffmann FM, Rajski SR, Osada H, Shen B. Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. Organic Letters. 11: 1639-42. PMID 19281218 DOI: 10.1021/ol900293j  1
2009 Lin S, Van Lanen SG, Shen B. A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 4183-8. PMID 19246381 DOI: 10.1073/pnas.0808880106  1
2009 Liao R, Duan L, Lei C, Pan H, Ding Y, Zhang Q, Chen D, Shen B, Yu Y, Liu W. Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chemistry & Biology. 16: 141-7. PMID 19246004 DOI: 10.1016/j.chembiol.2009.01.007  1
2009 Pinchot SN, Adler JT, Luo Y, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H. Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. American Journal of Surgery. 197: 313-9. PMID 19245907 DOI: 10.1016/j.amjsurg.2008.10.007  1
2009 Huang SX, Zhao LX, Tang SK, Jiang CL, Duan Y, Shen B. Erythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600. Organic Letters. 11: 1353-6. PMID 19228040 DOI: 10.1021/ol900143j  1
2009 Li W, Luo Y, Ju J, Rajski SR, Osada H, Shen B. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. Journal of Natural Products. 72: 450-9. PMID 19191560 DOI: 10.1021/np8007478  1
2009 Wang L, Tao M, Wendt-Pienkoski E, Galm U, Coughlin JM, Shen B. Functional characterization of tlmK unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway. The Journal of Biological Chemistry. 284: 8256-64. PMID 19189972 DOI: 10.1074/jbc.M900640200  1
2009 Smanski MJ, Peterson RM, Rajski SR, Shen B. Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin. Antimicrobial Agents and Chemotherapy. 53: 1299-304. PMID 19164156 DOI: 10.1128/AAC.01358-08  1
2009 Beerman TA, Gawron LS, Shin S, Shen B, McHugh MM. C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells. Cancer Research. 69: 593-8. PMID 19147573 DOI: 10.1158/0008-5472.CAN-08-2753  1
2009 Ju J, Rajski SR, Lim SK, Seo JW, Peters NR, Hoffmann FM, Shen B. Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration. Journal of the American Chemical Society. 131: 1370-1. PMID 19132897 DOI: 10.1021/ja808462p  1
2009 Galm U, Wendt-Pienkowski E, Wang L, George NP, Oh TJ, Yi F, Tao M, Coughlin JM, Shen B. The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892. Molecular Biosystems. 5: 77-90. PMID 19081934 DOI: 10.1039/b814075h  1
2009 Feng Z, Wang L, Rajski SR, Xu Z, Coeffet-LeGal MF, Shen B. Engineered production of iso-migrastatin in heterologous Streptomyces hosts. Bioorganic & Medicinal Chemistry. 17: 2147-53. PMID 19010685 DOI: 10.1016/j.bmc.2008.10.074  1
2008 Li W, Ju J, Rajski SR, Osada H, Shen B. Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis. The Journal of Biological Chemistry. 283: 28607-17. PMID 18708355 DOI: 10.1074/jbc.M804279200  0.64
2008 Galm U, Wang L, Wendt-Pienkowski E, Yang R, Liu W, Tao M, Coughlin JM, Shen B. In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway. The Journal of Biological Chemistry. 283: 28236-45. PMID 18697737 DOI: 10.1074/jbc.M804971200  1
2008 Ju J, Rajski SR, Lim SK, Seo JW, Peters NR, Hoffmann FM, Shen B. Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency. Bioorganic & Medicinal Chemistry Letters. 18: 5951-4. PMID 18684620 DOI: 10.1016/j.bmcl.2008.07.072  1
2008 Chen Y, Wendt-Pienkowski E, Shen B. Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts. Journal of Bacteriology. 190: 5587-96. PMID 18556785 DOI: 10.1128/JB.00592-08  0.96
2008 Jiang H, Zirkle R, Metz JG, Braun L, Richter L, Van Lanen SG, Shen B. The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis. Journal of the American Chemical Society. 130: 6336-7. PMID 18444614 DOI: 10.1021/ja801911t  1
2008 Lin S, Van Lanen SG, Shen B. Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027. Journal of the American Chemical Society. 130: 6616-23. PMID 18426211 DOI: 10.1021/ja710601d  0.64
2008 Song D, Coughlin J, Ju J, Zhou X, Shen B, Zhao C, Deng Z. Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453. Acta Biochimica Et Biophysica Sinica. 40: 319-26. PMID 18401530 DOI: 10.1111/j.1745-7270.2008.00408.x  1
2008 Van Lanen SG, Shen B. Biosynthesis of enediyne antitumor antibiotics. Current Topics in Medicinal Chemistry. 8: 448-59. PMID 18397168  0.64
2008 Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B. Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. The Journal of Biological Chemistry. 283: 14694-702. PMID 18387946 DOI: 10.1074/jbc.M802206200  1
2008 Van Lanen SG, Shen B. Advances in polyketide synthase structure and function. Current Opinion in Drug Discovery & Development. 11: 186-95. PMID 18283606  0.64
2008 Chen Y, Luo Y, Ju J, Wendt-Pienkowski E, Rajski SR, Shen B. Identification of fredericamycin E from Streptomyces griseus: Insights into fredericamycin A biosynthesis highlighting carbaspirocycle formation. Journal of Natural Products. 71: 431-7. PMID 18232659 DOI: 10.1021/np070664n  0.96
2008 Zhang J, Van Lanen SG, Ju J, Liu W, Dorrestein PC, Li W, Kelleher NL, Shen B. A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 1460-5. PMID 18223152 DOI: 10.1073/pnas.0711625105  1
2008 Van Lanen SG, Lin S, Shen B. Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism. Proceedings of the National Academy of Sciences of the United States of America. 105: 494-9. PMID 18182490 DOI: 10.1073/pnas.0708750105  0.64
2008 Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD. Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM. Bioorganic & Medicinal Chemistry Letters. 18: 3099-102. PMID 18078753 DOI: 10.1016/j.bmcl.2007.11.046  1
2007 Christianson CV, Montavon TJ, Festin GM, Cooke HA, Shen B, Bruner SD. The mechanism of MIO-based aminomutases in beta-amino acid biosynthesis. Journal of the American Chemical Society. 129: 15744-5. PMID 18052279 DOI: 10.1021/ja0762689  1
2007 Ju J, Seo JW, Her Y, Lim SK, Shen B. New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus. Organic Letters. 9: 5183-6. PMID 17997563 DOI: 10.1021/ol702249g  0.64
2007 Kennedy DR, Ju J, Shen B, Beerman TA. Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proceedings of the National Academy of Sciences of the United States of America. 104: 17632-7. PMID 17978180 DOI: 10.1073/pnas.0708274104  1
2007 Galm U, Shen B. Natural product drug discovery: the times have never been better. Chemistry & Biology. 14: 1098-104. PMID 17961822 DOI: 10.1016/j.chembiol.2007.10.004  0.64
2007 Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B. Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. Journal of the American Chemical Society. 129: 13082-94. PMID 17918933 DOI: 10.1021/ja073275o  1
2007 Lin S, Van Lanen SG, Shen B. Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027. Journal of the American Chemical Society. 129: 12432-8. PMID 17887753 DOI: 10.1021/ja072311g  0.64
2007 Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD. Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Journal of the American Chemical Society. 129: 7728-9. PMID 17539640 DOI: 10.1021/ja071886a  1
2007 Christianson CV, Montavon TJ, Van Lanen SG, Shen B, Bruner SD. The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry. 46: 7205-14. PMID 17516659 DOI: 10.1021/bi7003685  1
2007 Tang GL, Cheng YQ, Shen B. Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine. The Journal of Biological Chemistry. 282: 20273-82. PMID 17502372 DOI: 10.1074/jbc.M702814200  0.52
2007 Guan C, Ju J, Borlee BR, Williamson LL, Shen B, Raffa KF, Handelsman J. Signal mimics derived from a metagenomic analysis of the gypsy moth gut microbiota. Applied and Environmental Microbiology. 73: 3669-76. PMID 17435000 DOI: 10.1128/AEM.02617-06  1
2007 Wang L, Yun BS, George NP, Wendt-Pienkowski E, Galm U, Oh TJ, Coughlin JM, Zhang G, Tao M, Shen B. Glycopeptide antitumor antibiotic zorbamycin from Streptomyces flavoviridis ATCC 21892: strain improvement and structure elucidation. Journal of Natural Products. 70: 402-6. PMID 17311457 DOI: 10.1021/np060592k  1
2007 Kennedy DR, Gawron LS, Ju J, Liu W, Shen B, Beerman TA. Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks. Cancer Research. 67: 773-81. PMID 17234789 DOI: 10.1158/0008-5472.CAN-06-2893  1
2007 Tao M, Wang L, Wendt-Pienkowski E, George NP, Galm U, Zhang G, Coughlin JM, Shen B. The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics. Molecular Biosystems. 3: 60-74. PMID 17216057 DOI: 10.1039/b615284h  1
2006 Van Lanen SG, Shen B. Progress in combinatorial biosynthesis for drug discovery. Drug Discovery Today. Technologies. 3: 285-92. PMID 24980530 DOI: 10.1016/j.ddtec.2006.09.014  0.64
2006 Galm U, Shen B. Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. Expert Opinion On Drug Discovery. 1: 409-37. PMID 23495943 DOI: 10.1517/17460441.1.5.409  0.64
2006 Ju J, Lim SK, Jiang H, Seo JW, Her Y, Shen B. Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues. Organic Letters. 8: 5865-8. PMID 17134292 DOI: 10.1021/ol062470p  0.64
2006 Huang Y, Wendt-Pienkowski E, Shen B. A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus. The Journal of Biological Chemistry. 281: 29660-8. PMID 16895912 DOI: 10.1074/jbc.M604895200  0.96
2006 Dorrestein PC, Van Lanen SG, Li W, Zhao C, Deng Z, Shen B, Kelleher NL. The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. Journal of the American Chemical Society. 128: 10386-7. PMID 16895402 DOI: 10.1021/ja0639362  1
2006 Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B. Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. The Journal of Biological Chemistry. 281: 29633-40. PMID 16887797 DOI: 10.1074/jbc.M605887200  1
2006 Li W, Ju J, Osada H, Shen B. Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus. Journal of Bacteriology. 188: 4148-52. PMID 16707708 DOI: 10.1128/JB.00172-06  0.64
2006 Zhao C, Ju J, Christenson SD, Smith WC, Song D, Zhou X, Shen B, Deng Z. Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453. Journal of Bacteriology. 188: 4142-7. PMID 16707707 DOI: 10.1128/JB.00173-06  1
2006 Van Lanen SG, Shen B. Microbial genomics for the improvement of natural product discovery. Current Opinion in Microbiology. 9: 252-60. PMID 16651020 DOI: 10.1016/j.mib.2006.04.002  0.64
2006 Tang GL, Cheng YQ, Shen B. Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. Journal of Natural Products. 69: 387-93. PMID 16562841 DOI: 10.1021/np050467t  0.52
2005 Wendt-Pienkowski E, Huang Y, Zhang J, Li B, Jiang H, Kwon H, Hutchinson CR, Shen B. Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. Journal of the American Chemical Society. 127: 16442-52. PMID 16305230 DOI: 10.1021/ja054376u  1
2005 Ju J, Lim SK, Jiang H, Seo JW, Shen B. Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds. Journal of the American Chemical Society. 127: 11930-1. PMID 16117518 DOI: 10.1021/ja053118u  0.64
2005 Van Lanen SG, Dorrestein PC, Christenson SD, Liu W, Ju J, Kelleher NL, Shen B. Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. Journal of the American Chemical Society. 127: 11594-5. PMID 16104723 DOI: 10.1021/ja052871k  1
2005 Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B. The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases. Chemistry & Biology. 12: 293-302. PMID 15797213 DOI: 10.1016/j.chembiol.2004.12.013  1
2005 Ju J, Lim SK, Jiang H, Shen B. Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. Journal of the American Chemical Society. 127: 1622-3. PMID 15700980 DOI: 10.1021/ja043808i  0.64
2005 Galm U, Hager MH, Van Lanen SG, Ju J, Thorson JS, Shen B. Antitumor antibiotics: bleomycin, enediynes, and mitomycin. Chemical Reviews. 105: 739-58. PMID 15700963 DOI: 10.1021/cr030117g  1
2004 Ju J, Ozanick SG, Shen B, Thomas MG. Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861. Chembiochem : a European Journal of Chemical Biology. 5: 1281-5. PMID 15368582 DOI: 10.1002/cbic.200400136  0.64
2004 Murrell JM, Liu W, Shen B. Biochemical characterization of the SgcA1 alpha-D-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production. Journal of Natural Products. 67: 206-13. PMID 14987060 DOI: 10.1021/np0340403  1
2003 Du L, Cheng YQ, Ingenhorst G, Tang GL, Huang Y, Shen B. Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules. Genetic Engineering. 25: 227-67. PMID 15260241  0.96
2003 Christenson SD, Wu W, Spies MA, Shen B, Toney MD. Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. Biochemistry. 42: 12708-18. PMID 14580219 DOI: 10.1021/bi035223r  1
2003 Shen B, Liu W, Nonaka K. Enediyne natural products: biosynthesis and prospect towards engineering novel antitumor agents. Current Medicinal Chemistry. 10: 2317-25. PMID 14529344  1
2003 Liu W, Ahlert J, Gao Q, Wendt-Pienkowski E, Shen B, Thorson JS. Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model. Proceedings of the National Academy of Sciences of the United States of America. 100: 11959-63. PMID 14528002 DOI: 10.1073/pnas.2034291100  1
2003 Christenson SD, Liu W, Toney MD, Shen B. A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. Journal of the American Chemical Society. 125: 6062-3. PMID 12785829 DOI: 10.1021/ja034609m  1
2003 Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotechnology. 21: 187-90. PMID 12536216 DOI: 10.1038/nbt784  1
2002 Kwon HJ, Smith WC, Scharon AJ, Hwang SH, Kurth MJ, Shen B. C-O bond formation by polyketide synthases. Science (New York, N.Y.). 297: 1327-30. PMID 12193782 DOI: 10.1126/science.1073175  1
2002 Liu W, Christenson SD, Standage S, Shen B. Biosynthesis of the enediyne antitumor antibiotic C-1027. Science (New York, N.Y.). 297: 1170-3. PMID 12183628 DOI: 10.1126/science.1072110  1
2002 Shen B, Du L, Sanchez C, Edwards DJ, Chen M, Murrell JM. Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003. Journal of Natural Products. 65: 422-31. PMID 11908996 DOI: 10.1021/np010550q  1
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