Hugues Bedouelle, Ph.D. - Publications

Institut Pasteur, Paris, Paris, France 
Protein engineering

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Bedouelle H. Principles and equations for measuring and interpreting protein stability: from monomer to tetramer. Biochimie. PMID 26607240 DOI: 10.1016/j.biochi.2015.11.013  1
2014 Lisova O, Belkadi L, Bedouelle H. Direct and indirect interactions in the recognition between a cross-neutralizing antibody and the four serotypes of dengue virus Journal of Molecular Recognition. 27: 205-214. PMID 24591178 DOI: 10.1002/jmr.2352  1
2013 Zidane N, Dussart P, Bremand L, Bedouelle H. Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins Bmc Infectious Diseases. 13. PMID 23815496 DOI: 10.1186/1471-2334-13-302  1
2013 Zidane N, Dussart P, Bremand L, Villani ME, Bedouelle H. Thermodynamic stability of domain III from the envelope protein of flaviviruses and its improvement by molecular design Protein Engineering, Design and Selection. 26: 389-399. PMID 23479674 DOI: 10.1093/protein/gzt010  1
2013 Hegerle N, Rayat L, Dore G, Zidane N, Bedouelle H, Guiso N. In-vitro and in-vivo analysis of the production of the Bordetella type three secretion system effector A in Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica Microbes and Infection. 15: 399-408. PMID 23470234 DOI: 10.1016/j.micinf.2013.02.006  1
2013 Zidane N, Ould-Abeih MB, Petit-Topin I, Bedouelle H. The folded and disordered domains of human ribosomal protein SA have both idiosyncratic and shared functions as membrane receptors Bioscience Reports. 33: 113-124. PMID 23137297 DOI: 10.1042/BSR20120103  1
2012 Ould-Abeih MB, Petit-Topin I, Zidane N, Baron B, Bedouelle H. Multiple folding states and disorder of ribosomal protein SA, a membrane receptor for laminin, anticarcinogens, and pathogens Biochemistry. 51: 4807-4821. PMID 22640394 DOI: 10.1021/bi300335r  1
2012 Cockburn JJB, Navarro Sanchez ME, Fretes N, Urvoas A, Staropoli I, Kikuti CM, Coffey LL, Arenzana Seisdedos F, Bedouelle H, Rey FA. Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody Structure. 20: 303-314. PMID 22285214 DOI: 10.1016/j.str.2012.01.001  1
2011 Miranda FF, Brient-Litzler E, Zidane N, Pecorari F, Bedouelle H. Reagentless fluorescent biosensors from artificial families of antigen binding proteins Biosensors and Bioelectronics. 26: 4184-4190. PMID 21565483 DOI: 10.1016/j.bios.2011.04.030  1
2010 Brandler S, Ruffie C, Najburg V, Frenkiel MP, Bedouelle H, Desprès P, Tangy F. Pediatric measles vaccine expressing a dengue tetravalent antigen elicits neutralizing antibodies against all four dengue viruses Vaccine. 28: 6730-6739. PMID 20688034 DOI: 10.1016/j.vaccine.2010.07.073  1
2010 Ravaoarisoa E, Zamanka H, Fusai T, Bellalou J, Bedouelle H, Mercereau-Puijalon O, Fandeur T. Recombinant antibodies specific for the Plasmodium falciparum histidine-rich protein 2 Mabs. 2: 416-427. PMID 20581462  1
2010 Brient-Litzler E, Plückthun A, Bedouelle H. Knowledge-based design of reagentless fluorescent biosensors from a designed ankyrin repeat protein. Protein Engineering, Design & Selection : Peds. 23: 229-41. PMID 19945965 DOI: 10.1093/protein/gzp074  1
2009 Tawar RG, Duquerroy S, Vonrhein C, Varela PF, Damier-Piolle L, Castagné N, MacLellan K, Bedouelle H, Bricogne G, Bhella D, Eléouët JF, Rey FA. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science (New York, N.Y.). 326: 1279-83. PMID 19965480 DOI: 10.1126/science.1177634  1
2009 Hershkovitz O, Rosental B, Rosenberg LA, Navarro-Sanchez ME, Jivov S, Zilka A, Gershoni-Yahalom O, Brient-Litzler E, Bedouelle H, Ho JW, Campbell KS, Rager-Zisman B, Despres P, Porgador A. NKp44 receptor mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells Journal of Immunology. 183: 2610-2621. PMID 19635919 DOI: 10.4049/jimmunol.0802806  1
2008 Pelat T, Bedouelle H, Rees AR, Crennell SJ, Lefranc MP, Thullier P. Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering Journal of Molecular Biology. 384: 1400-1407. PMID 18976662 DOI: 10.1016/j.jmb.2008.10.033  1
2008 Laffly E, Pelat T, Cédrone F, Blésa S, Bedouelle H, Thullier P. Improvement of an Antibody Neutralizing the Anthrax Toxin by Simultaneous Mutagenesis of Its Six Hypervariable Loops Journal of Molecular Biology. 378: 1094-1103. PMID 18423488 DOI: 10.1016/j.jmb.2008.03.045  1
2007 Brandler S, Lucas-Hourani M, Moris A, Frenkiel MP, Combredet C, Février M, Bedouelle H, Schwartz O, Desprès P, Tangy F. Pediatric measles vaccine expressing a dengue antigen induces durable serotype-specific neutralizing antibodies to dengue virus. Plos Neglected Tropical Diseases. 1: e96. PMID 18160988 DOI: 10.1371/journal.pntd.0000096  1
2007 Lisova O, Hardy F, Petit V, Bedouelle H. Mapping to completeness and trasplantation of a group-specific, discontinuous, neutralizing epitope in the envelope protein of dengue virus Journal of General Virology. 88: 2387-2397. PMID 17698647 DOI: 10.1099/vir.0.83028-0  1
2006 Monsellier E, Bedouelle H. Improving the stability of an antibody variable fragment by a combination of knowledge-based approaches: validation and mechanisms. Journal of Molecular Biology. 362: 580-93. PMID 16926023 DOI: 10.1016/j.jmb.2006.07.044  1
2006 Bedouelle H, Belkadi L, England P, Guijarro JI, Lisova O, Urvoas A, Delepierre M, Thullier P. Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus. The Febs Journal. 273: 34-46. PMID 16367746 DOI: 10.1111/j.1742-4658.2005.05045.x  1
2005 Monsellier E, Bedouelle H. Quantitative measurement of protein stability from unfolding equilibria monitored with the fluorescence maximum wavelength. Protein Engineering, Design & Selection : Peds. 18: 445-56. PMID 16087653 DOI: 10.1093/protein/gzi046  1
2005 Malandain C, Fayolle F, Bedouelle H. Biosensors for the environment Oil and Gas Science and Technology. 60: 887-897. DOI: 10.2516/ogst:2005062  1
2004 Renard M, Bedouelle H. Improving the sensitivity and dynamic range of reagentless fluorescent immunosensors by knowledge-based design Biochemistry. 43: 15453-15462. PMID 15581357 DOI: 10.1021/bi048922s  1
2003 Renard M, Belkadi L, Bedouelle H. Deriving topological constraints from functional data for the design of reagentless fluorescent immunosensors Journal of Molecular Biology. 326: 167-175. PMID 12547199 DOI: 10.1016/S0022-2836(02)01334-7  1
2002 Bedouelle H, Renard M, Belkadi L, England P. Harnessing malE for the study of antigen/antibody recognitions. Research in Microbiology. 153: 395-8. PMID 12405344 DOI: 10.1016/S0923-2508(02)01337-2  1
2002 Renard M, Belkadi L, Hugo N, England P, Altschuh D, Bedouelle H. Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies. Journal of Molecular Biology. 318: 429-42. PMID 12051849 DOI: 10.1016/S0022-2836(02)00023-2  1
2002 Guijarro JI, Pintar A, Prochnicka-Chalufour A, Guez V, Gilquin B, Bedouelle H, Delepierre M. Structure and dynamics of the anticodon arm binding domain of Bacillus stearothermophilus tyrosyl-tRNA synthetase Structure. 10: 311-317. PMID 12005430 DOI: 10.1016/S0969-2126(02)00699-8  1
2001 Thullier P, Demangel C, Bedouelle H, Mégret F, Jouan A, Deubel V, Mazié JC, Lafaye P. Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: Insight into the neutralization mechanism Journal of General Virology. 82: 1885-1892. PMID 11457994  1
2001 Gaillard C, Bedouelle H. An essential residue in the flexible peptide linking the two idiosynchratic domains of bacterial tyrosyl-tRNA synthetases Biochemistry. 40: 7192-7199. PMID 11401566  1
2001 Bedouelle H, England P, Martineau P, Minard P, Sodoyer R. Directed evolution of molecules: A close examination of molecular diversity | La diversité moléculaire passée au crible Biofutur. 46-51.  1
2000 Rondard P, Bedouelle H. Mutational scanning of a hairpin loop in the tryptophan synthase beta-subunit implicated in allostery and substrate channeling. Biological Chemistry. 381: 1185-93. PMID 11209753 DOI: 10.1515/BC.2000.146  1
2000 Guez V, Nair S, Chaffotte A, Bedouelle H. The anticodon-binding domain of tyrosyl-tRNA synthetase: State of folding and origin of the crystallographic disorder Biochemistry. 39: 1739-1747. PMID 10677223 DOI: 10.1021/bi992382v  1
1999 Jermutus L, Guez V, Bedouelle H. Disordered C-terminal domain of tyrosyl-tRNA synthetase: Secondary structure prediction Biochimie. 81: 235-244. PMID 10385005 DOI: 10.1016/S0300-9084(99)80057-1  1
1999 Pintar A, Guez V, Castagné C, Bedouelle H, Delepierre M. Secondary structure of the C-terminal domain of the tyrosyl-transfer RNA synthetase from Bacillus stearothermophilus: A novel type of anticodon binding domain? Febs Letters. 446: 81-85. PMID 10100619 DOI: 10.1016/S0014-5793(99)00191-X  1
1999 Park YC, Guez V, Bedouelle H. Experimental evolution of a dense cluster of residues in Tyrosyl-tRNA synthetase: Quantitative effects on activity, stability and dimerization Journal of Molecular Biology. 286: 563-577. PMID 9973571 DOI: 10.1006/jmbi.1998.2501  1
1999 England P, Nageotte R, Renard M, Page AL, Bedouelle H. Functional characterization of the somatic hypermutation process leading to antibody D1.3, a high affinity antibody directed against lysozyme. Journal of Immunology (Baltimore, Md. : 1950). 162: 2129-36. PMID 9973487  1
1998 Rondard P, Bedouelle H. A mutational approach shows similar mechanisms of recognition for the isolated and integrated versions of a protein epitope. The Journal of Biological Chemistry. 273: 34753-9. PMID 9856999 DOI: 10.1074/jbc.273.52.34753  1
1998 Guermonprez P, England P, Bedouelle H, Leclerc C. The rate of dissociation between antibody and antigen determines the efficiency of antibody-mediated antigen presentation to T cells. Journal of Immunology (Baltimore, Md. : 1950). 161: 4542-8. PMID 9794380  1
1998 Park YC, Bedouelle H. Dimeric tyrosyl-tRNA synthetase from Bacillus stearothermophilus unfolds through a monomeric intermediate. A quantitative analysis under equilibrium conditions Journal of Biological Chemistry. 273: 18052-18059. PMID 9660761 DOI: 10.1074/jbc.273.29.18052  1
1997 Brégégère F, England P, Djavadi-Ohaniance L, Bedouelle H. Recognition of E. coli tryptophan synthase by single-chain Fv fragments: comparison of PCR-cloning variants with the parental antibodies. Journal of Molecular Recognition : Jmr. 10: 169-81. PMID 9476520 DOI: 10.1002/(SICI)1099-1352(199707/08)10:4<169::AID-JMR362>3.0.CO;2-U  1
1997 Rondard P, Goldberg ME, Bedouelle H. Mutational analysis of an antigenic peptide shows recognition in a loop conformation. Biochemistry. 36: 8962-8. PMID 9220984 DOI: 10.1021/bi9625096  1
1997 Rondard P, Brégégère F, Lecroisey A, Delepierre M, Bedouelle H. Conformational and functional properties of an undecapeptide epitope fused with the C-terminal end of the maltose binding protein. Biochemistry. 36: 8954-61. PMID 9220983 DOI: 10.1021/bi962508d  1
1997 England P, Brégégère F, Bedouelle H. Energetic and kinetic contributions of contact residues of antibody D1.3 in the interaction with lysozyme. Biochemistry. 36: 164-72. PMID 8993330 DOI: 10.1021/bi961419y  1
1996 Blondel A, Nageotte R, Bedouelle H. Destabilizing interactions between the partners of a bifunctional fusion protein Protein Engineering. 9: 231-238. PMID 9005445  1
1996 Guez-Ivanier V, Bedouelle H. Disordered C-terminal domain of tyrosyl transfer-RNA synthetase: Evidence for a folded state Journal of Molecular Biology. 255: 110-120. PMID 8568859 DOI: 10.1006/jmbi.1996.0010  1
1995 Bedouelle H, Nageotte R. Macromolecular recognition through electrostatic repulsion Embo Journal. 14: 2945-2950. PMID 7796819  1
1994 Bregegere F, Schwartz J, Bedouelle H. Bifunctional hybrids between the variable domains of an immunoglobulin and the maltose-binding protein of Escherichia coli: Production, purification and antigen binding Protein Engineering. 7: 271-280. PMID 8170930  1
1993 Guez-Ivanier V, Hermann M, Baldwin D, Bedouelle H. Mapping the stability determinants of bacterial tyrosyl transfer RNA synthetase by an experimental evolutionary approach Journal of Molecular Biology. 234: 209-221. PMID 8230200 DOI: 10.1006/jmbi.1993.1575  1
1993 Bedouelle H, Guez-Ivanier V, Nageotte R. Discrimination between transfer-RNAs by tyrosyl-tRNA synthetase Biochimie. 75: 1099-1108. PMID 8199245 DOI: 10.1016/0300-9084(93)90009-H  1
1993 Bedouelle H. Symmetrical interactions between the translational operator of the thrS gene and dimeric threonyl transfer RNA synthetase Journal of Molecular Biology. 230: 704-708. PMID 7683056 DOI: 10.1006/jmbi.1993.1190  1
1992 Vidal-Cros A, Bedouelle H. Role of residue Glu152 in the discrimination between transfer RNAs by Tyrosyl-tRNA synthetase from Bacillus stearothermophilus Journal of Molecular Biology. 223: 801-810. PMID 1542120 DOI: 10.1016/0022-2836(92)90991-R  1
1992 Bregegere F, Bedouelle H. Expression, export and purification of antibody fragments fused to the maltose-binding protein of Escherichia coli | EXPRESSION, EXPORTATION ET PURIFICATION DE FRAGMENTS D'ANTICORPS FUSIONNES A LA PROTEINE AFFINE DU MALTOSE D'ESCHERICHIA COLI Comptes Rendus De L'Academie Des Sciences - Serie Iii. 314: 527-532. PMID 1521173  1
1991 Blondel A, Bedouelle H. Engineering the quaternary structure of an exported protein with a leucine zipper. Protein Engineering. 4: 457-61. PMID 1881871 DOI: 10.1093/protein/4.4.457  1
1990 Blondel A, Bedouelle H. Export and purification of a cytoplasmic dimeric protein by fusion to the maltose-binding protein of Escherichia coli European Journal of Biochemistry. 193: 325-330. PMID 2226455  1
1990 Hermann M, Bedouelle H. A method for monitoring double restriction cuts within a polylinker Research in Microbiology. 141: 187-189. PMID 2161117 DOI: 10.1016/0923-2508(90)90028-O  1
1990 Bedouelle H. Recognition of tRNATyr by tyrosyl-tRNA synthetase Biochimie. 72: 589-598. PMID 2126463 DOI: 10.1016/0300-9084(90)90122-W  1
1990 Bedouelle H, Guez V, Vidal-Cros A, Hermann M. Overproduction of tyrosyl-tRNA synthetase is toxic to Escherichia coli: A genetic analysis Journal of Bacteriology. 172: 3940-3945. PMID 2113914  1
1989 Labouze E, Bedouelle H. Structural and kinetic bases for the recognition of tRNAtyr by tyrosyl-tRNA synthetase Journal of Molecular Biology. 205: 729-735. PMID 2467006 DOI: 10.1016/0022-2836(89)90317-3  1
1988 Fersht AR, Knill-Jones JW, Bedouelle H, Winter G. Reconstruction by site-directed mutagenesis of the transition state for the activation of tyrosine by the tyrosyl-tRNA synthetase: A mobile loop envelopes the transition state in an induced-fit mechanism Biochemistry. 27: 1581-1587. PMID 3284584  1
1988 Bedouelle H, Duplay P. Production in Escherichia coli and one-step purification of bifunctional hybrid proteins which bind maltose. Export of the Klenow polymerase into the periplasmic space. European Journal of Biochemistry. 171: 541-549. PMID 3278900  1
1988 Hofnung M, Bedouelle H, Boulain JC, Clement JM, Charbit A, Duplay P, Gehring K, Martineau P, Saurin W, Szmelcman S. Genetic approaches to the study and use of proteins: Random point mutations and random linker insertions Bulletin De L'Institut Pasteur. 86: 95-101.  1
1987 Bedouelle H, Duplay P, Hofnung M. Expression, export and one-step purification of proteins by fusion to the MalE protein of E. coli | Expression, exportation et purification en une étape de protéines par fusion à la protéine MalE d'E. coli. Comptes Rendus De L"Academie Des Sciences. Serie Iii, Sciences De La Vie. 305: 623-626. PMID 3123019  1
1987 Duplay P, Szmelcman S, Bedouelle H, Hofnung M. Silent and functional changes in the periplasmic maltose-binding protein of Escherichia coli K12. I. Transport of maltose Journal of Molecular Biology. 194: 663-673. PMID 2821264 DOI: 10.1016/0022-2836(87)90243-9  1
1986 Bedouelle H, Winter G. A model of synthetase/transfer RNA interaction as deduced by protein engineering Nature. 320: 371-373. PMID 3960121 DOI: 10.1038/320371a0  1
1986 Carter P, Bedouelle H, Winter G. Construction of heterodimer tyrosyl-tRNA synthetase shows tRNA(Tyr) interacts with both subunits Proceedings of the National Academy of Sciences of the United States of America. 83: 1189-1192. PMID 3006039  1
1985 Bedouelle H, Carter P, Waye MM, Winter G, Lowe DM, Wilkinson AJ, Fersht AR. Engineering of tyrosyl tRNA synthetase. Biochimie. 67: 737-43. PMID 3910110  1
1985 Duplay P, Bedouelle H, Szmelcman S, Hofnung M. Linker mutagenesis in the gene encoding the periplasmic maltose-binding protein of E. coli. Biochimie. 67: 849-851. PMID 3002495 DOI: 10.1016/S0300-9084(85)80178-4  1
1985 Carter P, Bedouelle H, Winter G. Improved oligonudeotide site-directed rautagenesis using M13 vectors Nucleic Acids Research. 13: 4431-4443. PMID 2989795 DOI: 10.1093/nar/13.12.4431  1
1984 Duplay P, Bedouelle H, Fowler A, Zabin I, Saurin W, Hofnung M. Sequences of the malE gene and of its product, the maltose-binding protein of Escherichia coli K12 Journal of Biological Chemistry. 259: 10606-10613. PMID 6088507  1
1983 Bedouelle H. Mutations in the promoter regions of the malEFG and malK-lamB operons of Escherichia coli K12 Journal of Molecular Biology. 170: 861-882. PMID 6417341 DOI: 10.1016/S0022-2836(83)80192-2  1
1982 Bedouelle H. Structure of the malB regulatory interval Annales De Microbiologie. 133: 65-70. PMID 7041747  1
1982 Bedouelle H, Hofnung M. A DNA sequence containing the control regions of the malEFG and malK-lamB operons in Escherichia coli K12 Mgg Molecular & General Genetics. 185: 82-87. PMID 6283312 DOI: 10.1007/BF00333794  1
1982 Bedouelle H, Schmeissner U, Hofnung M, Rosenberg M. Promoters of the malEFG and malK-lamB operons in Escherichia coli K12 Journal of Molecular Biology. 161: 519-531. PMID 6185687 DOI: 10.1016/0022-2836(82)90405-3  1
1981 Bedouelle H, Hofnung M. Functional implications of secondary structure analysis of wild type and mutant bacterial signal peptides. Progress in Clinical and Biological Research. 63: 399-403. PMID 7312870  1
1980 Bedouelle H, Bassford PJ, Fowler AV, Zabin I, Beckwith J, Hofnung M. Mutations which alter the function of the signal sequence of the maltose binding protein of Escherichia coli Nature. 285: 78-81. PMID 6990274 DOI: 10.1038/285078a0  1
1980 Hermann M, Chaudé O, Weill N, Bedouelle H, Hofnung M. Adaptation of the salmonella/mammalian microsome test to the determination of the mutagenic properties of mineral oils. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 77: 327-339. PMID 6990250 DOI: 10.1016/0165-1218(80)90004-X  1
1978 Bedouelle H, Hofnung M. Short term tests of carcinogenesis. Evaluation, predictive values, and diverse strategies | Tests à court terme du pouvoir cancérogène. Evaluation, valeurs prédictives, stratégies diverses. Comptes Rendus Hebdomadaires Des Seances De L"Academie Des Sciences. Serie D: Sciences Naturelles. 287: 891-894. PMID 104799  1
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