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Matthew David Disney, PhD - Publications

Affiliations: 
2010- Chemistry Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Chemical Biology, Nucleic Acids, Chemistry
Website:
http://www.scripps.edu/disney/lab_members.html

118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chen JL, Moss WN, Spencer A, Zhang P, Childs-Disney JL, Disney MD. The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology. Plos One. 14: e0219210. PMID 31291322 DOI: 10.1371/journal.pone.0219210  1
2019 Disney MD, Velagapudi SP, Li Y, Costales MG, Childs-Disney JL. Identifying and validating small molecules interacting with RNA (SMIRNAs). Methods in Enzymology. 623: 45-66. PMID 31239057 DOI: 10.1016/bs.mie.2019.04.027  1
2019 O'Leary CA, Andrews RJ, Tompkins VS, Chen JL, Childs-Disney JL, Disney MD, Moss WN. RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression. Plos One. 14: e0213758. PMID 31206539 DOI: 10.1371/journal.pone.0213758  1
2019 Costales MG, Suresh B, Vishnu K, Disney MD. Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA. Cell Chemical Biology. PMID 31130520 DOI: 10.1016/j.chembiol.2019.04.008  0.48
2019 Costales MG, Disney MD. Adding Broccoli to the Biosensor Menu. Cell Chemical Biology. 26: 463-465. PMID 31002799 DOI: 10.1016/j.chembiol.2019.04.004  0.48
2019 Velagapudi SP, Li Y, Disney MD. A cross-linking approach to map small molecule-RNA binding sites in cells. Bioorganic & Medicinal Chemistry Letters. PMID 30987892 DOI: 10.1016/j.bmcl.2019.04.001  0.52
2019 Angelbello AJ, Chen JL, Disney MD. Small molecule targeting of RNA structures in neurological disorders. Annals of the New York Academy of Sciences. PMID 30964958 DOI: 10.1111/nyas.14051  0.52
2019 Angelbello AJ, Rzuczek SG, Mckee KK, Chen JL, Olafson H, Cameron MD, Moss WN, Wang ET, Disney MD. Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model. Proceedings of the National Academy of Sciences of the United States of America. PMID 30926669 DOI: 10.1073/pnas.1901484116  0.52
2019 Costales MG, Hoch DG, Abegg D, Childs-Disney JL, Velagapudi SP, Adibekian A, Disney MD. A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin. Journal of the American Chemical Society. PMID 30726072 DOI: 10.1021/jacs.8b10558  1
2018 Childs-Disney JL, Tran T, Vummidi BR, Velagapudi SP, Haniff HS, Matsumoto Y, Crynen G, Southern MR, Biswas A, Wang ZF, Tellinghuisen TL, Disney MD. A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence. Chem. 4: 2384-2404. PMID 30719503 DOI: 10.1016/j.chempr.2018.08.003  1
2018 Wales DJ, Disney MD, Yildirim I. Computational Investigation of RNA A-Bulges Related to Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism. The Journal of Physical Chemistry. B. PMID 30517788 DOI: 10.1021/acs.jpcb.8b09139  0.4
2018 Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD. The Hairpin Form of r(GC) in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules. Cell Chemical Biology. PMID 30503283 DOI: 10.1016/j.chembiol.2018.10.018  1
2018 Disney MD, Dwyer BG, Childs-Disney JL. Drugging the RNA World. Cold Spring Harbor Perspectives in Biology. 10. PMID 30385607 DOI: 10.1101/cshperspect.a034769  1
2018 Li Y, Disney MD. Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype. Acs Chemical Biology. PMID 30375843 DOI: 10.1021/acschembio.8b00827  0.48
2018 Velagapudi SP, Costales MG, Vummidi BR, Nakai Y, Angelbello AJ, Tran T, Haniff HS, Matsumoto Y, Wang ZF, Chatterjee AK, Childs-Disney JL, Disney MD. Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs. Cell Chemical Biology. 25: 1086-1094.e7. PMID 30251629 DOI: 10.1016/j.chembiol.2018.05.015  1
2018 Costales MG, Matsumoto Y, Velagapudi SP, Disney MD. Small Molecule Targeted Recruitment of a Nuclease to RNA. Journal of the American Chemical Society. PMID 29792692 DOI: 10.1021/jacs.8b01233  0.52
2018 Angelbello AJ, Chen JL, Childs-Disney JL, Zhang P, Wang ZF, Disney MD. Using Genome Sequence to Enable the Design of Medicines and Chemical Probes. Chemical Reviews. PMID 29322778 DOI: 10.1021/acs.chemrev.7b00504  1
2017 Guan L, Luo Y, Ja WW, Disney MD. Small molecule alteration of RNA sequence in cells and animals. Bioorganic & Medicinal Chemistry Letters. PMID 29079470 DOI: 10.1016/j.bmcl.2017.10.034  0.44
2017 Chen JL, VanEtten DM, Fountain MA, Yildirim I, Disney MD. Structure and dynamics of RNA repeat expansions that cause Huntington's Disease and myotonic dystrophy type 1. Biochemistry. PMID 28617590 DOI: 10.1021/acs.biochem.7b00252  0.52
2017 Velagapudi SP, Luo Y, Tran T, Haniff HS, Nakai Y, Fallahi M, Martinez GJ, Childs-Disney JL, Disney MD. Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA. Acs Central Science. 3: 205-216. PMID 28386598 DOI: 10.1021/acscentsci.7b00009  1
2017 Costales MG, Haga CL, Velagapudi SP, Childs-Disney JL, Phinney DG, Disney MD. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. Journal of the American Chemical Society. PMID 28240549 DOI: 10.1021/jacs.6b11273  1
2017 Haga CL, Velagapudi SP, Childs-Disney JL, Strivelli J, Disney MD, Phinney DG. Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods. Methods in Molecular Biology (Clifton, N.J.). 1517: 179-198. PMID 27924483 DOI: 10.1007/978-1-4939-6563-2_13  1
2016 Park H, Tran T, Lee JH, Park H, Disney MD. Controlled dehydration improves the diffraction quality of two RNA crystals. Bmc Structural Biology. 16: 19. PMID 27809904 DOI: 10.1186/s12900-016-0069-1  0.44
2016 Yang WY, He F, Strack RL, Oh SY, Frazer M, Jaffrey SR, Todd PK, Disney MD. Small Molecule Recognition and Tools to Study Modulation of r(CGG)exp in Fragile X-Associated Tremor Ataxia Syndrome. Acs Chemical Biology. PMID 27276216 DOI: 10.1021/acschembio.6b00147  1
2016 Yang WY, Gao R, Southern M, Sarkar PS, Disney MD. Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10. Nature Communications. 7: 11647. PMID 27248057 DOI: 10.1038/ncomms11647  0.44
2016 Velagapudi SP, Cameron MD, Haga CL, Rosenberg LH, Lafitte M, Duckett DR, Phinney DG, Disney MD. Design of a small molecule against an oncogenic noncoding RNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 27170187 DOI: 10.1073/pnas.1523975113  1
2016 Costales MG, Rzuczek SG, Disney MD. Comparison of small molecules and oligonucleotides that target a toxic, non-coding RNA. Bioorganic & Medicinal Chemistry Letters. PMID 27117425 DOI: 10.1016/j.bmcl.2016.04.025  0.48
2016 Disney MD, Winkelsas AM, Velagapudi SP, Southern M, Fallahi M, Childs-Disney JL. Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs. Acs Chemical Biology. PMID 27097021 DOI: 10.1021/acschembio.6b00001  1
2016 Liu B, Childs-Disney JL, Znosko BM, Wang D, Fallahi M, Gallo SM, Disney MD. Analysis of secondary structural elements in human microRNA hairpin precursors. Bmc Bioinformatics. 17: 112. PMID 26928172 DOI: 10.1186/s12859-016-0960-6  1
2015 Childs-Disney JL, Disney MD. Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma in Cellulo. Acs Chemical Biology. PMID 26551630 DOI: 10.1021/acschembio.5b00615  1
2015 Childs-Disney JL, Disney MD. Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells. Annual Review of Pharmacology and Toxicology. PMID 26514201 DOI: 10.1146/annurev-pharmtox-010715-103910  1
2015 Yildirim I, Chakraborty D, Disney MD, Wales DJ, Schatz GC. Computational Investigation of RNA CUG Repeats Responsible for Myotonic Dystrophy 1. Journal of Chemical Theory and Computation. 11: 4943-4958. PMID 26500461 DOI: 10.1021/acs.jctc.5b00728  1
2015 Rzuczek SG, Southern MR, Disney MD. Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy. Acs Chemical Biology. PMID 26414664 DOI: 10.1021/acschembio.5b00430  1
2015 Garbaccio RM, Johnson DS, Hong J, Disney MD. Preface. Bioorganic & Medicinal Chemistry Letters. PMID 26358161 DOI: 10.1016/j.bmcl.2015.08.083  1
2015 Haga CL, Velagapudi SP, Strivelli JR, Yang WY, Disney MD, Phinney DG. Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. Acs Chemical Biology. PMID 26181590 DOI: 10.1021/acschembio.5b00265  1
2015 Bernat V, Disney MD. RNA Structures as Mediators of Neurological Diseases and as Drug Targets. Neuron. 87: 28-46. PMID 26139368 DOI: 10.1016/j.neuron.2015.06.012  1
2015 Park H, González ÀL, Yildirim I, Tran T, Lohman JR, Fang P, Guo M, Disney MD. Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10). Biochemistry. 54: 3851-9. PMID 26039897 DOI: 10.1021/acs.biochem.5b00551  1
2015 Yang WY, Wilson HD, Velagapudi SP, Disney MD. Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA. Journal of the American Chemical Society. 137: 5336-45. PMID 25825793 DOI: 10.1021/ja507448y  1
2015 Velagapudi SP, Vummidi BR, Disney MD. Small molecule chemical probes of microRNA function. Current Opinion in Chemical Biology. 24: 97-103. PMID 25500006 DOI: 10.1016/j.cbpa.2014.10.024  1
2014 Rzuczek SG, Park H, Disney MD. A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor. Angewandte Chemie (International Ed. in English). 53: 10956-9. PMID 25164984 DOI: 10.1002/anie.201406465  1
2014 Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, ... ... Disney MD, et al. Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS. Neuron. 83: 1043-50. PMID 25132468 DOI: 10.1016/j.neuron.2014.07.041  1
2014 Luo Y, Disney MD. Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA. Chembiochem : a European Journal of Chemical Biology. 15: 2041-4. PMID 25115866 DOI: 10.1002/cbic.201402069  1
2014 Hoskins JW, Ofori LO, Chen CZ, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan JJ, Zheng W, Austin CP, Disney MD, Miller BL, Thornton CA. Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects. Nucleic Acids Research. 42: 6591-602. PMID 24799433 DOI: 10.1093/nar/gku275  1
2014 Colak D, Zaninovic N, Cohen MS, Rosenwaks Z, Yang WY, Gerhardt J, Disney MD, Jaffrey SR. Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome. Science (New York, N.Y.). 343: 1002-5. PMID 24578575 DOI: 10.1126/science.1245831  1
2014 Velagapudi SP, Gallo SM, Disney MD. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nature Chemical Biology. 10: 291-7. PMID 24509821 DOI: 10.1038/nchembio.1452  1
2014 Tran T, Childs-Disney JL, Liu B, Guan L, Rzuczek S, Disney MD. Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides. Acs Chemical Biology. 9: 904-12. PMID 24506227 DOI: 10.1021/cb400875u  1
2014 Velagapudi SP, Disney MD. Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. Chemical Communications (Cambridge, England). 50: 3027-9. PMID 24503738 DOI: 10.1039/c3cc00173c  1
2014 Disney MD, Yildirim I, Childs-Disney JL. Methods to enable the design of bioactive small molecules targeting RNA. Organic & Biomolecular Chemistry. 12: 1029-39. PMID 24357181 DOI: 10.1039/c3ob42023j  1
2014 Childs-Disney JL, Yildirim I, Park H, Lohman JR, Guan L, Tran T, Sarkar P, Schatz GC, Disney MD. Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity. Acs Chemical Biology. 9: 538-50. PMID 24341895 DOI: 10.1021/cb4007387  1
2014 Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, ... ... Disney MD, et al. Errata to Discovery of a biomarker and lead small molecules to target r(GGGGCC)-Associated Defects in c9FTD/ALS [Neuron, 83, (2014) 1043-1050] Neuron. 84: 239. DOI: 10.1016/j.neuron.2014.09.019  1
2013 Strack RL, Disney MD, Jaffrey SR. A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA. Nature Methods. 10: 1219-24. PMID 24162923 DOI: 10.1038/nmeth.2701  1
2013 Rzuczek SG, Gao Y, Tang ZZ, Thornton CA, Kodadek T, Disney MD. Features of modularly assembled compounds that impart bioactivity against an RNA target. Acs Chemical Biology. 8: 2312-21. PMID 24032410 DOI: 10.1021/cb400265y  1
2013 Disney MD. Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts. Drug Discovery Today. 18: 1228-36. PMID 23939337 DOI: 10.1016/j.drudis.2013.07.024  1
2013 Guan L, Disney MD. Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions. Angewandte Chemie (International Ed. in English). 52: 10010-3. PMID 23913698 DOI: 10.1002/anie.201301639  1
2013 Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, ... Disney MD, et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nature Communications. 4: 2044. PMID 23806903 DOI: 10.1038/ncomms3044  1
2013 Velagapudi SP, Disney MD. Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing. Bioorganic & Medicinal Chemistry. 21: 6132-8. PMID 23719281 DOI: 10.1016/j.bmc.2013.04.072  1
2013 Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault C, Page A, Tassone F, Willemsen R, Disney MD, Hagerman PJ, Todd PK, et al. Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome. Cell Reports. 3: 869-80. PMID 23478018 DOI: 10.1016/j.celrep.2013.02.004  1
2013 Yildirim I, Park H, Disney MD, Schatz GC. A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations. Journal of the American Chemical Society. 135: 3528-38. PMID 23441937 DOI: 10.1021/ja3108627  1
2013 Guan L, Disney MD. Small-molecule-mediated cleavage of RNA in living cells. Angewandte Chemie (International Ed. in English). 52: 1462-5. PMID 23280953 DOI: 10.1002/anie.201206888  1
2012 Childs-Disney JL, Parkesh R, Nakamori M, Thornton CA, Disney MD. Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1. Acs Chemical Biology. 7: 1984-93. PMID 23130637 DOI: 10.1021/cb3001606  1
2012 Tran T, Disney MD. Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations. Nature Communications. 3: 1125. PMID 23047683 DOI: 10.1038/ncomms2119  1
2012 Velagapudi SP, Pushechnikov A, Labuda LP, French JM, Disney MD. Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening. Acs Chemical Biology. 7: 1902-9. PMID 22958065 DOI: 10.1021/cb300213g  1
2012 Disney MD, Liu B, Yang WY, Sellier C, Tran T, Charlet-Berguerand N, Childs-Disney JL. A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome. Acs Chemical Biology. 7: 1711-8. PMID 22948243 DOI: 10.1021/cb300135h  1
2012 Childs-Disney JL, Hoskins J, Rzuczek SG, Thornton CA, Disney MD. Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. Acs Chemical Biology. 7: 856-62. PMID 22332923 DOI: 10.1021/cb200408a  1
2012 Parkesh R, Childs-Disney JL, Nakamori M, Kumar A, Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, Disney MD. Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching. Journal of the American Chemical Society. 134: 4731-42. PMID 22300544 DOI: 10.1021/ja210088v  1
2012 Kumar A, Parkesh R, Sznajder LJ, Childs-Disney JL, Sobczak K, Disney MD. Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts. Acs Chemical Biology. 7: 496-505. PMID 22252896 DOI: 10.1021/cb200413a  1
2012 Guan L, Disney MD. Recent advances in developing small molecules targeting RNA. Acs Chemical Biology. 7: 73-86. PMID 22185671 DOI: 10.1021/cb200447r  1
2012 Disney MD. Studying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray. Methods in Molecular Biology (Clifton, N.J.). 808: 303-20. PMID 22057534 DOI: 10.1007/978-1-61779-373-8_21  1
2011 Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney MD. Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 × 1 nucleotide UU internal loop conformations. Biochemistry. 50: 9928-35. PMID 21988728 DOI: 10.1021/bi2013068  1
2011 Childs-Disney JL, Tsitovich PB, Disney MD. Using modularly assembled ligands to bind RNA internal loops separated by different distances. Chembiochem : a European Journal of Chemical Biology. 12: 2143-6. PMID 21830289 DOI: 10.1002/cbic.201100298  1
2011 Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. Chembiochem : a European Journal of Chemical Biology. 12: 2140-2. PMID 21766409 DOI: 10.1002/cbic.201100337  1
2011 Lee MM, French JM, Disney MD. Influencing uptake and localization of aminoglycoside-functionalized peptoids. Molecular Biosystems. 7: 2441-51. PMID 21611644 DOI: 10.1039/c1mb05074e  1
2011 Velagapudi SP, Seedhouse SJ, French J, Disney MD. Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis. Journal of the American Chemical Society. 133: 10111-8. PMID 21604752 DOI: 10.1021/ja200212b  1
2011 Tran T, Disney MD. Molecular recognition of 6'-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches. Biochemistry. 50: 962-9. PMID 21207945 DOI: 10.1021/bi101724h  1
2011 Parkesh R, Fountain M, Disney MD. NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)₂ reveal a dynamic UU internal loop found in myotonic dystrophy type 1. Biochemistry. 50: 599-601. PMID 21204525 DOI: 10.1021/bi101896j  1
2010 Aminova O, Disney MD. A microarray-based method to perform nucleic acid selections. Methods in Molecular Biology (Clifton, N.J.). 669: 209-24. PMID 20857369 DOI: 10.1007/978-1-60761-845-4_17  1
2010 Tsitovich PB, Pushechnikov A, French JM, Disney MD. A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity. Chembiochem : a European Journal of Chemical Biology. 11: 1656-60. PMID 20629012 DOI: 10.1002/cbic.201000300  1
2010 Velagapudi SP, Seedhouse SJ, Disney MD. Structure-activity relationships through sequencing (StARTS) defines optimal and suboptimal RNA motif targets for small molecules. Angewandte Chemie (International Ed. in English). 49: 3816-8. PMID 20397174 DOI: 10.1002/anie.200907257  1
2010 Tran T, Disney MD. Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides. Biochemistry. 49: 1833-42. PMID 20108982 DOI: 10.1021/bi901998m  1
2010 Seedhouse SJ, Labuda LP, Disney MD. The Privileged Chemical Space Predictor (PCSP): a computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries. Bioorganic & Medicinal Chemistry Letters. 20: 1338-43. PMID 20097562 DOI: 10.1016/j.bmcl.2010.01.017  1
2010 Disney MD, Lee MM, Pushechnikov A, Childs-Disney JL. The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies. Chembiochem : a European Journal of Chemical Biology. 11: 375-82. PMID 20058255 DOI: 10.1002/cbic.200900716  1
2009 Lee MM, Childs-Disney JL, Pushechnikov A, French JM, Sobczak K, Thornton CA, Disney MD. Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy. Journal of the American Chemical Society. 131: 17464-72. PMID 19904940 DOI: 10.1021/ja906877y  1
2009 Paul DJ, Seedhouse SJ, Disney MD. Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions. Nucleic Acids Research. 37: 5894-907. PMID 19726586 DOI: 10.1093/nar/gkp594  1
2009 Pushechnikov A, Lee MM, Childs-Disney JL, Sobczak K, French JM, Thornton CA, Disney MD. Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. Journal of the American Chemical Society. 131: 9767-79. PMID 19552411 DOI: 10.1021/ja9020149  1
2009 Lee MM, Pushechnikov A, Disney MD. Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2. Acs Chemical Biology. 4: 345-55. PMID 19348464 DOI: 10.1021/cb900025w  1
2009 Labuda LP, Pushechnikov A, Disney MD. Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron. Acs Chemical Biology. 4: 299-307. PMID 19278238 DOI: 10.1021/cb800313m  1
2008 Disney MD. Short-circuiting RNA splicing. Nature Chemical Biology. 4: 723-4. PMID 19008883 DOI: 10.1038/nchembio1208-723  1
2008 Aminova O, Paul DJ, Childs-Disney JL, Disney MD. Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions. Biochemistry. 47: 12670-9. PMID 18991404 DOI: 10.1021/bi8012615  1
2008 Barrett OJ, Pushechnikov A, Wu M, Disney MD. Studying aminoglycoside modification by the acetyltransferase class of resistance-causing enzymes via microarray. Carbohydrate Research. 343: 2924-31. PMID 18774127 DOI: 10.1016/j.carres.2008.08.018  1
2008 Disney MD, Labuda LP, Paul DJ, Poplawski SG, Pushechnikov A, Tran T, Velagapudi SP, Wu M, Childs-Disney JL. Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. Journal of the American Chemical Society. 130: 11185-94. PMID 18652457 DOI: 10.1021/ja803234t  1
2008 Childs-Disney JL, Disney MD. A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections. Rna (New York, N.Y.). 14: 390-4. PMID 18065718 DOI: 10.1261/rna.576908  1
2007 Childs-Disney JL, Wu M, Pushechnikov A, Aminova O, Disney MD. A small molecule microarray platform to select RNA internal loop-ligand interactions. Acs Chemical Biology. 2: 745-54. PMID 17975888 DOI: 10.1021/cb700174r  1
2007 Disney MD, Childs-Disney JL. "Supra"molecular recognition of Galectin 1. Chemistry & Biology. 14: 1095-7. PMID 17961821 DOI: 10.1016/j.chembiol.2007.10.002  1
2007 Disney MD, Barrett OJ. An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance. Biochemistry. 46: 11223-30. PMID 17867707 DOI: 10.1021/bi701071h  1
2007 Disney MD, Childs-Disney JL. Using selection to identify and chemical microarray to study the RNA internal loops recognized by 6'-N-acylated kanamycin A. Chembiochem : a European Journal of Chemical Biology. 8: 649-56. PMID 17394189 DOI: 10.1002/cbic.200600569  1
2006 Barrett OJ, Childs JL, Disney MD. Chemical microarrays to identify ligands that bind pathogenic cells. Chembiochem : a European Journal of Chemical Biology. 7: 1882-5. PMID 17009274 DOI: 10.1002/cbic.200600260  1
2006 Brun MA, Disney MD, Seeberger PH. Miniaturization of microwave-assisted carbohydrate functionalization to create oligosaccharide microarrays. Chembiochem : a European Journal of Chemical Biology. 7: 421-4. PMID 16444768 DOI: 10.1002/cbic.200500361  1
2006 Kehr JC, Zilliges Y, Springer A, Disney MD, Ratner DD, Bouchier C, Seeberger PH, de Marsac NT, Dittmann E. A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Molecular Microbiology. 59: 893-906. PMID 16420359 DOI: 10.1111/j.1365-2958.2005.05001.x  1
2005 Disney MD, Hook DF, Namoto K, Seeberger PH, Seebach D. N-linked glycosylated beta-peptides are resistant to degradation by glycoamidase A. Chemistry & Biodiversity. 2: 1624-34. PMID 17191959 DOI: 10.1002/cbdv.200590132  1
2005 Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, Gigliotti F. Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis. Antimicrobial Agents and Chemotherapy. 49: 1326-30. PMID 15793106 DOI: 10.1128/AAC.49.4.1326-1330.2005  1
2004 Disney MD, Seeberger PH. The use of carbohydrate microarrays to study carbohydrate-cell interactions and to detect pathogens. Chemistry & Biology. 11: 1701-7. PMID 15610854 DOI: 10.1016/j.chembiol.2004.10.011  1
2004 Disney MD, Childs JL, Turner DH. Hoechst 33258 selectively inhibits group I intron self-splicing by affecting RNA folding. Chembiochem : a European Journal of Chemical Biology. 5: 1647-52. PMID 15532034 DOI: 10.1002/cbic.200400159  1
2004 Disney MD, Zheng J, Swager TM, Seeberger PH. Detection of bacteria with carbohydrate-functionalized fluorescent polymers. Journal of the American Chemical Society. 126: 13343-6. PMID 15479090 DOI: 10.1021/ja047936i  1
2004 Ratner DM, Adams EW, Disney MD, Seeberger PH. Tools for glycomics: mapping interactions of carbohydrates in biological systems. Chembiochem : a European Journal of Chemical Biology. 5: 1375-83. PMID 15457538 DOI: 10.1002/cbic.200400106  1
2004 Disney MD, Seeberger PH. Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 3308-14. PMID 15224340 DOI: 10.1002/chem.200306017  1
2004 Mathews DH, Disney MD, Childs JL, Schroeder SJ, Zuker M, Turner DH. Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure. Proceedings of the National Academy of Sciences of the United States of America. 101: 7287-92. PMID 15123812 DOI: 10.1073/pnas.0401799101  1
2004 Disney MD, Magnet S, Blanchard JS, Seeberger PH. Aminoglycoside microarrays to study antibiotic resistance. Angewandte Chemie (International Ed. in English). 43: 1591-4. PMID 15022242 DOI: 10.1002/anie.200353236  1
2004 Disney MD, Childs JL, Turner DH. New approaches to targeting RNA with oligonucleotides: inhibition of group I intron self-splicing. Biopolymers. 73: 151-61. PMID 14691946 DOI: 10.1002/bip.10520  1
2004 Disney MD, Seeberger PH. Carbohydrate arrays as tools for the glycomics revolution Drug Discovery Today: Targets. 3: 151-158. DOI: 10.1016/S1741-8372(04)02443-0  1
2003 Du H, Disney MD, Miller BL, Krauss TD. Hybridization-based unquenching of DNA hairpins on au surfaces: prototypical "molecular beacon" biosensors. Journal of the American Chemical Society. 125: 4012-3. PMID 12670198 DOI: 10.1021/ja0290781  1
2003 Disney MD, Haidaris CG, Turner DH. Uptake and antifungal activity of oligonucleotides in Candida albicans. Proceedings of the National Academy of Sciences of the United States of America. 100: 1530-4. PMID 12552085 DOI: 10.1073/pnas.0337462100  1
2002 Childs JL, Disney MD, Turner DH. Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing. Proceedings of the National Academy of Sciences of the United States of America. 99: 11091-6. PMID 12169671 DOI: 10.1073/pnas.172391199  1
2002 Disney MD, Turner DH. Molecular recognition by the Candida albicans group I intron: tertiary interactions with an imino G.A pair facilitate binding of the 5' exon and lower the KM for guanosine. Biochemistry. 41: 8113-9. PMID 12069604 DOI: 10.1021/bi020102x  1
2001 Disney MD, Matray T, Gryaznov SM, Turner DH. Binding enhancement by tertiary interactions and suicide inhibition of a Candida albicans group I intron by phosphoramidate and 2'-O-methyl hexanucleotides. Biochemistry. 40: 6520-6. PMID 11371215 DOI: 10.1021/bi002009j  1
2001 Disney MD, Haidaris CG, Turner DH. Recognition elements for 5' exon substrate binding to the Candida albicans group I intron. Biochemistry. 40: 6507-19. PMID 11371214 DOI: 10.1021/bi002008r  1
2000 Disney MD, Gryaznov SM, Turner DH. Contributions of individual nucleotides to tertiary binding of substrate by a Pneumocystis carinii group I intron. Biochemistry. 39: 14269-78. PMID 11087376 DOI: 10.1021/bi001345x  1
2000 Disney MD, Testa SM, Turner DH. Targeting a Pneumocystis carinii group I intron with methylphosphonate oligonucleotides: backbone charge is not required for binding or reactivity. Biochemistry. 39: 6991-7000. PMID 10841781 DOI: 10.1021/bi992937m  1
1999 Testa SM, Disney MD, Turner DH, Kierzek R. Thermodynamics of RNA-RNA duplexes with 2- or 4-thiouridines: implications for antisense design and targeting a group I intron. Biochemistry. 38: 16655-62. PMID 10600128 DOI: 10.1021/bi991187d  1
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