Justin Legleiter, PhD - Publications

Affiliations: 
2000-2005 Chemistry Carnegie Mellon University, Pittsburgh, PA 
 2005-2008 Gladstone Institute of Neurological Disease University of California, San Francisco, San Francisco, CA 
 2008- Chemistry West Virginia University, Morgantown, WV, United States 
Area:
Amyloid, macromolecular self-assembly, atomic force microscopy, neurodegeneration
Website:
http://legleiterlab.wvu.edu/

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pilkington AW, Donohoe GC, Akhmedov NG, Ferrebee T, Valentine SJ, Legleiter J. Hydrogen peroxide modifies Aβ-membrane interactions with implications for Aβ40 aggregation. Biochemistry. PMID 31187978 DOI: 10.1021/acs.biochem.9b00233  1
2018 Chaibva M, Gao X, Jain P, Campbell WA, Frey SL, Legleiter J. Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes. Acs Omega. 3: 273-285. PMID 29399649 DOI: 10.1021/acsomega.7b01472  1
2017 Kumar B, Miller K, Charon NW, Legleiter J. Periplasmic flagella in Borrelia burgdoferi function to maintain cellular integrity upon external stress. Plos One. 12: e0184648. PMID 28898274 DOI: 10.1371/journal.pone.0184648  1
2017 Adegbuyiro A, Sedighi F, Pilkington AW, Groover S, Legleiter J. Proteins containing expanded polyglutamine tracts and neurodegenerative disease. Biochemistry. PMID 28170216 DOI: 10.1021/acs.biochem.6b00936  0.52
2016 Chaibva M, Jawahery S, Pilkington AW, Arndt JR, Sarver O, Valentine S, Matysiak S, Legleiter J. Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding. Biophysical Journal. 111: 349-62. PMID 27463137 DOI: 10.1016/j.bpj.2016.06.018  1
2015 Gao X, Campbell WA, Chaibva M, Jain P, Leslie AE, Frey SL, Legleiter J. Cholesterol modifies huntingtin binding to, disruption of, and aggregation on lipid membranes. Biochemistry. PMID 26652744 DOI: 10.1021/acs.biochem.5b00900  1
2015 Berger TR, Montie HL, Jain P, Legleiter J, Merry DE. Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy. Brain Research. PMID 26453288 DOI: 10.1016/j.brainres.2015.09.033  1
2015 Arndt JR, Kondalaji SG, Maurer MM, Parker A, Legleiter J, Valentine SJ. Huntingtin N-Terminal Monomeric and Multimeric Structures Destabilized by Covalent Modification of Heteroatomic Residues. Biochemistry. 54: 4285-96. PMID 26098795 DOI: 10.1021/acs.biochem.5b00478  1
2015 Arndt JR, Chaibva M, Legleiter J. The emerging role of the first 17 amino acids of huntingtin in Huntington's disease. Biomolecular Concepts. 6: 33-46. PMID 25741791 DOI: 10.1515/bmc-2015-0001  1
2015 Arndt JR, Brown RJ, Burke KA, Legleiter J, Valentine SJ. Lysine residues in the N-terminal huntingtin amphipathic α-helix play a key role in peptide aggregation. Journal of Mass Spectrometry : Jms. 50: 117-26. PMID 25601683 DOI: 10.1002/jms.3504  1
2015 Shamitko-Klingensmith N, Legleiter J. Investigation of temperature induced mechanical changes in supported bilayers by variants of tapping mode atomic force microscopy. Scanning. 37: 23-35. PMID 25369473 DOI: 10.1002/sca.21175  1
2015 Arndt JR, Chaibva M, Legleiter J. The emerging role of the first 17 amino acids of huntingtin in Huntington's disease Biomolecular Concepts. 6: 33-46. DOI: 10.1515/bmc-2015-0001  1
2015 Arndt JR, Kondalaji SG, Maurer MM, Parker A, Legleiter J, Valentine SJ. Huntingtin N-Terminal Monomeric and Multimeric Structures Destabilized by Covalent Modification of Heteroatomic Residues Biochemistry. 54: 4285-4296. DOI: 10.1021/acs.biochem.5b00478  1
2015 Chaibva M, Shamitko-Klingensmith N, Legleiter J. Recovering time-resolved imaging forces in solution by scanning probe acceleration microscopy: Theory and application Surface Science Tools For Nanomaterials Characterization. 69-89. DOI: 10.1007/978-3-662-44551-8_2  1
2015 Shamitko-Klingensmith N, Legleiter J. Investigation of temperature induced mechanical changes in supported bilayers by variants of tapping mode atomic force microscopy Scanning. 37: 23-35. DOI: 10.1002/sca.21175  1
2014 Yates EA, Legleiter J. Preparation protocols of Aβ(1-40) promote the formation of polymorphic aggregates and altered interactions with lipid bilayers Biochemistry. 53: 7038-7050. PMID 25349919 DOI: 10.1021/bi500792f  1
2014 Chaibva M, Burke KA, Legleiter J. Curvature enhances binding and aggregation of huntingtin at lipid membranes. Biochemistry. 53: 2355-65. PMID 24670006 DOI: 10.1021/bi401619q  1
2013 Burke KA, Legleiter J. Atomic force microscopy assays for evaluating polyglutamine aggregation in solution and on surfaces. Methods in Molecular Biology (Clifton, N.J.). 1017: 21-40. PMID 23719905 DOI: 10.1007/978-1-62703-438-8_2  1
2013 Burke KA, Hensal KM, Umbaugh CS, Chaibva M, Legleiter J. Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner. Biochimica Et Biophysica Acta. 1828: 1953-61. PMID 23643759 DOI: 10.1016/j.bbamem.2013.04.025  1
2013 Burke KA, Kauffman KJ, Umbaugh CS, Frey SL, Legleiter J. The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin. The Journal of Biological Chemistry. 288: 14993-5005. PMID 23572526 DOI: 10.1074/jbc.M112.446237  1
2013 Lotz GP, Legleiter J. The role of amyloidogenic protein oligomerization in neurodegenerative disease Journal of Molecular Medicine. 91: 653-664. PMID 23529761 DOI: 10.1007/s00109-013-1025-1  1
2013 Yates EA, Owens SL, Lynch MF, Cucco EM, Umbaugh CS, Legleiter J. Specific domains of Aβ facilitate aggregation on and association with lipid bilayers. Journal of Molecular Biology. 425: 1915-33. PMID 23524134 DOI: 10.1016/j.jmb.2013.03.022  1
2013 Burke KA, Yates EA, Legleiter J. Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration. Frontiers in Neurology. 4: 17. PMID 23459674 DOI: 10.3389/fneur.2013.00017  1
2013 Burke KA, Yates EA, Legleiter J. Amyloid-forming proteins alter the local mechanical properties of lipid membranes. Biochemistry. 52: 808-17. PMID 23331195 DOI: 10.1021/bi301070v  1
2012 Shamitko-Klingensmith N, Molchanoff KM, Burke KA, Magnone GJ, Legleiter J. Mapping the mechanical properties of cholesterol-containing supported lipid bilayers with nanoscale spatial resolution. Langmuir : the Acs Journal of Surfaces and Colloids. 28: 13411-22. PMID 22924735 DOI: 10.1021/la302705f  1
2012 Nucifora LG, Burke KA, Feng X, Arbez N, Zhu S, Miller J, Yang G, Ratovitski T, Delannoy M, Muchowski PJ, Finkbeiner S, Legleiter J, Ross CA, Poirier MA. Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein. The Journal of Biological Chemistry. 287: 16017-28. PMID 22433867 DOI: 10.1074/jbc.M111.252577  1
2012 Shamitko-Klingensmith N, Wambaugh KM, Burke KA, Magnone GJ, Legleiter J. Correlation of atomic force microscopy tapping forces to mechanical properties of lipid membranes Proceedings of the Asme Design Engineering Technical Conference. 5: 303-310. DOI: 10.1115/DETC2012-70233  1
2012 Legleiter J, Burke KA, Yates EA. Investigation of protein/lipid interactions via scanning probe acceleration microscopy: Theory and experiment Proceedings of the Asme Design Engineering Technical Conference. 5: 297-302. DOI: 10.1115/DETC2012-70228  1
2011 Yates EA, Cucco EM, Legleiter J. Point mutations in Aβ induce polymorphic aggregates at liquid/solid interfaces Acs Chemical Neuroscience. 2: 294-307. PMID 22778873 DOI: 10.1021/cn200001k  1
2011 Legleiter J, Fryer JD, Holtzman DM, Kowalewski A. The modulating effect of mechanical changes in lipid bilayers caused by apoE-containing lipoproteins on Aβ induced membrane disruption. Acs Chemical Neuroscience. 2: 588-599. PMID 22125665 DOI: 10.1021/cn2000475  1
2011 Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, et al. Identifying polyglutamine protein species in situ that best predict neurodegeneration. Nature Chemical Biology. 7: 925-34. PMID 22037470 DOI: 10.1038/nchembio.694  1
2011 Pifer PM, Yates EA, Legleiter J. Point mutations in Aβ result in the formation of distinct polymorphic aggregates in the presence of lipid bilayers Plos One. 6. PMID 21267410 DOI: 10.1371/journal.pone.0016248  1
2011 Burke KA, Godbey J, Legleiter J. Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy. Methods (San Diego, Calif.). 53: 275-84. PMID 21187152 DOI: 10.1016/j.ymeth.2010.12.028  1
2011 Legleiter J. Assessing Aβ aggregation state by atomic force microscopy. Methods in Molecular Biology (Clifton, N.J.). 670: 57-70. PMID 20967583 DOI: 10.1007/978-1-60761-744-0_5  1
2010 Lotz GP, Legleiter J, Aron R, Mitchell EJ, Huang SY, Ng C, Glabe C, Thompson LM, Muchowski PJ. Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle. The Journal of Biological Chemistry. 285: 38183-93. PMID 20864533 DOI: 10.1074/jbc.M110.160218  1
2010 Legleiter J, Mitchell E, Lotz GP, Sapp E, Ng C, DiFiglia M, Thompson LM, Muchowski PJ. Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo. The Journal of Biological Chemistry. 285: 14777-90. PMID 20220138 DOI: 10.1074/jbc.M109.093708  1
2010 Sathasivam K, Lane A, Legleiter J, Warley A, Woodman B, Finkbeiner S, Paganetti P, Muchowski PJ, Wilson S, Bates GP. Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease. Human Molecular Genetics. 19: 65-78. PMID 19825844 DOI: 10.1093/hmg/ddp467  1
2010 Kumar B, Pfifer PM, Giovengo A, Legleiter J. Publisher's note: "The effect of set point ratio and surface Young's modulus on maximum tapping forces in fluid tapping mode atomic force microscopy" (Journal of Applied Physics (2010) 107 (044508)) Journal of Applied Physics. 107. DOI: 10.1063/1.3374478  1
2010 Kumar B, Pifer PM, Giovengo A, Legleiter J. The effect of set point ratio and surface Young's modulus on maximum tapping forces in fluid tapping mode atomic force microscopy Journal of Applied Physics. 107. DOI: 10.1063/1.3309330  1
2010 Abraham A, Mihaliuk E, Kumar B, Legleiter J, Gullion T. Solid-state NMR study of cysteine on gold nanoparticles Journal of Physical Chemistry C. 114: 18109-18114. DOI: 10.1021/jp107112b  1
2009 Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, Finkbeiner S, Patterson PH, Muchowski PJ. Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment. The Journal of Biological Chemistry. 284: 21647-58. PMID 19491400 DOI: 10.1074/jbc.M109.016923  1
2009 Legleiter J. The effect of drive frequency and set point amplitude on tapping forces in atomic force microscopy: Simulation and experiment Nanotechnology. 20. PMID 19471079 DOI: 10.1088/0957-4484/20/24/245703  1
2009 Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L. Collagen VI protects neurons against Abeta toxicity. Nature Neuroscience. 12: 119-21. PMID 19122666 DOI: 10.1038/nn.2240  1
2007 Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. The Journal of Biological Chemistry. 282: 23818-28. PMID 17548355 DOI: 10.1074/jbc.M701078200  1
2006 Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE. Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Human Molecular Genetics. 15: 2743-51. PMID 16893904 DOI: 10.1093/hmg/ddl210  1
2006 Legleiter J, Park M, Cusick B, Kowalewski T. Scanning probe acceleration microscopy (SPAM) in fluids: mapping mechanical properties of surfaces at the nanoscale. Proceedings of the National Academy of Sciences of the United States of America. 103: 4813-8. PMID 16551751 DOI: 10.1073/pnas.0505628103  1
2006 Legleiter J, Park M, Cusick B, Kowalewski T. Scanning probe acceleration microscopy (SPAM) in fluids: Mapping mechanical properties of surfaces at the nanoscale Proceedings of the National Academy of Sciences of the United States of America. 103: 4813-4818. DOI: 10.1073/pnas.0505628103  1
2006 Kowalewski T, Legleiter J. Imaging stability and average tip-sample force in tapping mode atomic force microscopy Journal of Applied Physics. 99. DOI: 10.1063/1.2175473  1
2005 Legleiter J, Kowalewski T. Insights into fluid tapping-mode atomic force microscopy provided by numerical simulations Applied Physics Letters. 87: 1-3. DOI: 10.1063/1.2105991  1
2004 Legleiter J, Kowalewski T. Tapping, pulling, probing: atomic force microscopy in drug discovery. Drug Discovery Today. Technologies. 1: 163-9. PMID 24981387 DOI: 10.1016/j.ddtec.2004.09.008  1
2004 Legleiter J, DeMattos RB, Holtzman DM, Kowalewski T. In situ AFM studies of astrocyte-secreted apolipoprotein E- and J-containing lipoproteins. Journal of Colloid and Interface Science. 278: 96-106. PMID 15313642 DOI: 10.1016/j.jcis.2004.05.009  1
2004 Wahrle SE, Jiang H, Parsadanian M, Legleiter J, Han X, Fryer JD, Kowalewski T, Holtzman DM. ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. The Journal of Biological Chemistry. 279: 40987-93. PMID 15269217 DOI: 10.1074/jbc.M407963200  1
2004 Legleiter J, Czilli DL, Gitter B, DeMattos RB, Holtzman DM, Kowalewski T. Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy. Journal of Molecular Biology. 335: 997-1006. PMID 14698294 DOI: 10.1016/j.jmb.2003.11.019  1
2004 Legleiter J, Kowalewski T. Atomic force microscopy of beta-amyloid: static and dynamic studies of nanostructure and its formation. Methods in Molecular Biology (Clifton, N.J.). 242: 349-364. PMID 14578534  1
2004 Legleiter J, Kowalewski T. Tapping, pulling, probing: Atomic force microscopy in drug discovery Drug Discovery Today: Technologies. 1: 163-169. DOI: 10.1016/j.ddtec.2004.09.008  1
2003 Kowalewski T, Legleiter J. Improvement of Tapping Mode AFM Imaging Stability by Operation Far Below Resonance Frequency of a Cantilever American Society of Mechanical Engineers, Design Engineering Division (Publication) De. 116: 595-597. DOI: 10.1115/IMECE2003-55551  1
2002 Tristram-Nagle S, Liu Y, Legleiter J, Nagle JF. Structure of gel phase DMPC determined by X-ray diffraction. Biophysical Journal. 83: 3324-35. PMID 12496100 DOI: 10.1016/S0006-3495(02)75333-2  1
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