Jacob Matthew Hooker, Ph.D. - Publications

Affiliations: 
1998-2002 Chemistry  North Carolina State University, Raleigh, NC 
 1998-2002 Textile Chemistry North Carolina State University, Raleigh, NC 
 2002-2007 Chemistry University of California, Berkeley, Berkeley, CA 
 2007-2012 Medical Brookhaven National Laboratory, USA 
 2009- Radiology Harvard Medical School, Boston, MA, United States 
 2009- Martinos Center for Biomedical Imaging Massachusetts General Hospital, Boston, MA 
Area:
positron emission tomography, radiotracer chemistry, epigenetics, neuroscience, neurotransmitters
Website:
http://hookerlab.martinos.org/

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Weiwer M, Xu Q, Gale JP, Lewis M, Campbell AJ, Schroeder FA, Van de Bittner GC, Walk M, Amaya A, Su P, Đorđević L, Sacher JR, Skepner A, Fei D, Dennehy K, ... ... Hooker JM, et al. Functionally biased D2R antagonists: Targeting the β-arrestin pathway to improve antipsychotic treatment. Acs Chemical Biology. PMID 29485852 DOI: 10.1021/acschembio.8b00168  0.56
2017 Van de Bittner GC, Van de Bittner KC, Wey HY, Rowe W, Dharanipragada R, Ying X, Hurst W, Giovanni A, Alving K, Gupta A, Hoekman J, Hooker JM. Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A. Acs Chemical Neuroscience. PMID 29035509 DOI: 10.1021/acschemneuro.7b00357  0.56
2017 Van de Bittner GC, Riley MM, Cao L, Ehses J, Herrick SP, Ricq EL, Wey HY, O'Neill MJ, Ahmed Z, Murray TK, Smith JE, Wang C, Schroeder FA, Albers MW, Hooker JM. Nasal neuron PET imaging quantifies neuron generation and degeneration. The Journal of Clinical Investigation. PMID 28112682 DOI: 10.1172/JCI89162  0.56
2016 Ricq EL, Hooker JM, Haggarty SJ. Activity-Dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch. The Journal of Biological Chemistry. PMID 27634040 DOI: 10.1074/jbc.M116.734426  0.56
2016 Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Insights into neuroepigenetics through human histone deacetylase PET imaging. Science Translational Medicine. 8: 351ra106. PMID 27510902 DOI: 10.1126/scitranslmed.aaf7551  0.96
2016 Ricq EL, Hooker JM, Haggarty SJ. Toward Development of Epigenetic Drugs for CNS Disorders: Modulating Neuroplasticity via H3K4 Methylation. Psychiatry and Clinical Neurosciences. PMID 27485392 DOI: 10.1111/pcn.12426  0.56
2016 Rotstein BH, Liang SH, Placzek MS, Hooker JM, Gee AD, Dollé F, Wilson AA, Vasdev N. (11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals. Chemical Society Reviews. PMID 27276357 DOI: 10.1039/c6cs00310a  0.96
2016 Hooker JM. Neuroinflammation: Brain on Fire? Acs Chemical Neuroscience. 7: 415. PMID 27094163 DOI: 10.1021/acschemneuro.6b00104  0.96
2016 Hoover AJ, Lazari M, Ren H, Narayanam MK, Murphy JM, van Dam RM, Hooker JM, Ritter T. A Transmetalation Reaction Enables the Synthesis of [(18)F]5-Fluorouracil from [(18)F]Fluoride for Human PET Imaging. Organometallics. 35: 1008-1014. PMID 27087736 DOI: 10.1021/acs.organomet.6b00059  0.96
2016 Albrecht DS, Granziera C, Hooker JM, Loggia ML. In vivo imaging of human neuroinflammation. Acs Chemical Neuroscience. PMID 26985861 DOI: 10.1021/acschemneuro.6b00056  0.96
2016 Placzek MS, Zhao W, Wey HY, Morin TM, Hooker JM. PET Neurochemical Imaging Modes. Seminars in Nuclear Medicine. 46: 20-7. PMID 26687854 DOI: 10.1053/j.semnuclmed.2015.09.001  0.96
2015 Wang C, Placzek MS, Van de Bittner GC, Schroeder FA, Hooker JM. A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography. Acs Chemical Neuroscience. PMID 26694017 DOI: 10.1021/acschemneuro.5b00293  0.56
2015 Strebl MG, Wang C, Schroeder FA, Placzek MS, Wey HY, Van de Bittner GC, Neelamegam R, Hooker JM. Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. Acs Chemical Neuroscience. PMID 26675505 DOI: 10.1021/acschemneuro.5b00297  0.56
2015 Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, ... Hooker JM, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. Acs Chemical Biology. PMID 26640968 DOI: 10.1021/acschembio.5b00640  0.96
2015 Borra RJ, Cho HS, Bowen SL, Attenberger U, Arabasz G, Catana C, Josephson L, Rosen BR, Guimaraes AR, Hooker JM. Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model. Ejnmmi Physics. 2: 6. PMID 26501808 DOI: 10.1186/s40658-015-0109-0  0.96
2015 Lee SJ, Fowler JS, Alexoff D, Schueller M, Kim D, Nauth A, Weber C, Kim SW, Hooker JM, Ma L, Qu W. An efficient and practical synthesis of [2-(11)C]indole via superfast nucleophilic [(11)C]cyanation and RANEY® Nickel catalyzed reductive cyclization. Organic & Biomolecular Chemistry. PMID 26411301 DOI: 10.1039/c5ob01654a  0.96
2015 Sander CY, Hooker JM, Catana C, Rosen BR, Mandeville JB. Imaging Agonist-Induced D2/D3 Receptor Desensitization and Internalization In Vivo with PET/fMRI. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26388148 DOI: 10.1038/npp.2015.296  0.96
2015 Wang H, Liu L, Lu Y, Pan P, Hooker JM, Fowler JS, Tonge PJ. Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. PMID 26227776 DOI: 10.1016/j.bmcl.2015.07.019  0.96
2015 Placzek MS, Van de Bittner GC, Wey HY, Lukas SE, Hooker JM. Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26058662 DOI: 10.1038/npp.2015.159  0.56
2015 Liang SH, Holland JP, Stephenson NA, Kassenbrock A, Rotstein BH, Daignault CP, Lewis R, Collier L, Hooker JM, Vasdev N. PET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primates. Acs Chemical Neuroscience. 6: 535-41. PMID 25776827 DOI: 10.1021/acschemneuro.5b00055  0.96
2015 Wey HY, Wang C, Schroeder FA, Logan J, Price JC, Hooker JM. Kinetic Analysis and Quantification of [¹¹C]Martinostat for in Vivo HDAC Imaging of the Brain. Acs Chemical Neuroscience. 6: 708-15. PMID 25768025 DOI: 10.1021/acschemneuro.5b00066  0.96
2015 Huang X, Liu W, Hooker JM, Groves JT. Targeted fluorination with the fluoride ion by manganese-catalyzed decarboxylation. Angewandte Chemie (International Ed. in English). 54: 5241-5. PMID 25736895 DOI: 10.1002/anie.201500399  0.96
2015 Zürcher NR, Loggia ML, Lawson R, Chonde DB, Izquierdo-Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28. Neuroimage. Clinical. 7: 409-14. PMID 25685708 DOI: 10.1016/j.nicl.2015.01.009  0.96
2015 Zürcher NR, Bhanot A, McDougle CJ, Hooker JM. A systematic review of molecular imaging (PET and SPECT) in autism spectrum disorder: current state and future research opportunities. Neuroscience and Biobehavioral Reviews. 52: 56-73. PMID 25684726 DOI: 10.1016/j.neubiorev.2015.02.002  0.96
2015 Loggia ML, Chonde DB, Akeju O, Arabasz G, Catana C, Edwards RR, Hill E, Hsu S, Izquierdo-Garcia D, Ji RR, Riley M, Wasan AD, Zürcher NR, Albrecht DS, Vangel MG, ... ... Hooker JM, et al. Evidence for brain glial activation in chronic pain patients. Brain : a Journal of Neurology. 138: 604-15. PMID 25582579 DOI: 10.1093/brain/awu377  0.96
2014 Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, et al. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 3: e04499. PMID 25432022 DOI: 10.7554/eLife.04499  0.96
2014 Van de Bittner GC, Ricq EL, Hooker JM. A philosophy for CNS radiotracer design. Accounts of Chemical Research. 47: 3127-34. PMID 25272291 DOI: 10.1021/ar500233s  0.96
2014 Wang H, Lu Y, Liu L, Kim SW, Hooker JM, Fowler JS, Tonge PJ. Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus. European Journal of Medicinal Chemistry. 88: 66-73. PMID 25217335 DOI: 10.1016/j.ejmech.2014.09.008  0.96
2014 Wang C, Schroeder FA, Wey HY, Borra R, Wagner FF, Reis S, Kim SW, Holson EB, Haggarty SJ, Hooker JM. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. Journal of Medicinal Chemistry. 57: 7999-8009. PMID 25203558 DOI: 10.1021/jm500872p  0.96
2014 Schroeder FA, Wang C, Van de Bittner GC, Neelamegam R, Takakura WR, Karunakaran A, Wey HY, Reis SA, Gale J, Zhang YL, Holson EB, Haggarty SJ, Hooker JM. PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. Acs Chemical Neuroscience. 5: 1055-62. PMID 25188794 DOI: 10.1021/cn500162j  0.96
2014 Wey HY, Catana C, Hooker JM, Dougherty DD, Knudsen GM, Wang DJ, Chonde DB, Rosen BR, Gollub RL, Kong J. Simultaneous fMRI-PET of the opioidergic pain system in human brain. Neuroimage. 102: 275-82. PMID 25107855 DOI: 10.1016/j.neuroimage.2014.07.058  0.96
2014 Diyabalanage HV, Van de Bittner GC, Ricq EL, Hooker JM. A chemical strategy for the cell-based detection of HDAC activity. Acs Chemical Biology. 9: 1257-62. PMID 25056147 DOI: 10.1021/cb500248r  0.96
2014 Rotstein BH, Hooker JM, Woo J, Collier TL, Brady TJ, Liang SH, Vasdev N. Synthesis of [(11)C]Bexarotene by Cu-Mediated [(11)C]Carbon Dioxide Fixation and Preliminary PET Imaging. Acs Medicinal Chemistry Letters. 5: 668-72. PMID 24944741 DOI: 10.1021/ml500065q  0.96
2014 Villien M, Wey HY, Mandeville JB, Catana C, Polimeni JR, Sander CY, Zürcher NR, Chonde DB, Fowler JS, Rosen BR, Hooker JM. Dynamic functional imaging of brain glucose utilization using fPET-FDG. Neuroimage. 100: 192-9. PMID 24936683 DOI: 10.1016/j.neuroimage.2014.06.025  0.96
2014 Ren H, Wey HY, Strebl M, Neelamegam R, Ritter T, Hooker JM. Synthesis and imaging validation of [¹⁸F]MDL100907 enabled by Ni-mediated fluorination. Acs Chemical Neuroscience. 5: 611-5. PMID 24845956 DOI: 10.1021/cn500078e  0.96
2014 Granda ML, Schroeder FA, Borra RH, Schauer N, Aisaborhale E, Guimaraes AR, Hooker JM. First D1-like receptor PET imaging of the rat and primate kidney: implications for human disease monitoring. American Journal of Physiology. Renal Physiology. 307: F116-21. PMID 24808534 DOI: 10.1152/ajprenal.00111.2014  0.96
2014 Seo YJ, Kang Y, Muench L, Reid A, Caesar S, Jean L, Wagner F, Holson E, Haggarty SJ, Weiss P, King P, Carter P, Volkow ND, Fowler JS, Hooker JM, et al. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. Acs Chemical Neuroscience. 5: 588-96. PMID 24780082 DOI: 10.1021/cn500021p  0.96
2014 Huang X, Liu W, Ren H, Neelamegam R, Hooker JM, Groves JT. Late stage benzylic C-H fluorination with [¹⁸F]fluoride for PET imaging. Journal of the American Chemical Society. 136: 6842-5. PMID 24766544 DOI: 10.1021/ja5039819  0.96
2014 Pan P, Knudson SE, Bommineni GR, Li HJ, Lai CT, Liu N, Garcia-Diaz M, Simmerling C, Patil SS, Slayden RA, Tonge PJ. Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy. Chemmedchem. 9: 776-91. PMID 24616444 DOI: 10.1002/cmdc.201300429  0.96
2014 Neelamegam R, Hellenbrand T, Schroeder FA, Wang C, Hooker JM. Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization. Journal of Medicinal Chemistry. 57: 1488-94. PMID 24491146 DOI: 10.1021/jm401802f  0.96
2014 Wang C, Schroeder FA, Hooker JM. Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniques. Neuroscience. 264: 186-97. PMID 24051365 DOI: 10.1016/j.neuroscience.2013.09.018  0.96
2013 Seo YJ, Muench L, Reid A, Chen J, Kang Y, Hooker JM, Volkow ND, Fowler JS, Kim SW. Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain. Bioorganic & Medicinal Chemistry Letters. 23: 6700-5. PMID 24210501 DOI: 10.1016/j.bmcl.2013.10.038  0.96
2013 Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. Plos One. 8: e71323. PMID 23967191 DOI: 10.1371/journal.pone.0071323  0.96
2013 Wang C, Wilson CM, Moseley CK, Carlin SM, Hsu S, Arabasz G, Schroeder FA, Sander CY, Hooker JM. Evaluation of potential PET imaging probes for the orexin 2 receptors. Nuclear Medicine and Biology. 40: 1000-5. PMID 23953751 DOI: 10.1016/j.nucmedbio.2013.07.001  0.96
2013 Kim SW, Hooker JM, Otto N, Win K, Muench L, Shea C, Carter P, King P, Reid AE, Volkow ND, Fowler JS. Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET. Nuclear Medicine and Biology. 40: 912-8. PMID 23906667 DOI: 10.1016/j.nucmedbio.2013.06.007  0.96
2013 Schroeder FA, Chonde DB, Riley MM, Moseley CK, Granda ML, Wilson CM, Wagner FF, Zhang YL, Gale J, Holson EB, Haggarty SJ, Hooker JM. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neuroscience Letters. 550: 119-24. PMID 23810801 DOI: 10.1016/j.neulet.2013.06.016  0.96
2013 Wang Y, Zhang YL, Hennig K, Gale JP, Hong Y, Cha A, Riley M, Wagner F, Haggarty SJ, Holson E, Hooker J. Class I HDAC imaging using [ (3)H]CI-994 autoradiography. Epigenetics : Official Journal of the Dna Methylation Society. 8: 756-64. PMID 23803584 DOI: 10.4161/epi.25202  0.96
2013 Sander CY, Hooker JM, Catana C, Normandin MD, Alpert NM, Knudsen GM, Vanduffel W, Rosen BR, Mandeville JB. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Proceedings of the National Academy of Sciences of the United States of America. 110: 11169-74. PMID 23723346 DOI: 10.1073/pnas.1220512110  0.96
2013 Rotstein BH, Liang SH, Holland JP, Collier TL, Hooker JM, Wilson AA, Vasdev N. 11CO2 fixation: a renaissance in PET radiochemistry. Chemical Communications (Cambridge, England). 49: 5621-9. PMID 23673726 DOI: 10.1039/c3cc42236d  0.96
2013 Wang C, Moseley CK, Carlin SM, Wilson CM, Neelamegam R, Hooker JM. Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 23: 3389-92. PMID 23601709 DOI: 10.1016/j.bmcl.2013.03.079  0.96
2013 Kamlet AS, Neumann CN, Lee E, Carlin SM, Moseley CK, Stephenson N, Hooker JM, Ritter T. Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation. Plos One. 8: e59187. PMID 23554994 DOI: 10.1371/journal.pone.0059187  0.96
2013 Mandeville JB, Sander CY, Jenkins BG, Hooker JM, Catana C, Vanduffel W, Alpert NM, Rosen BR, Normandin MD. A receptor-based model for dopamine-induced fMRI signal. Neuroimage. 75: 46-57. PMID 23466936 DOI: 10.1016/j.neuroimage.2013.02.036  0.96
2013 Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Molecular Psychiatry. 18: 404-16. PMID 23439487 DOI: 10.1038/mp.2013.8  0.96
2013 Granda ML, Carlin SM, Moseley CK, Neelamegam R, Mandeville JB, Hooker JM. Synthesis and evaluation of methylated arylazepine compounds for PET imaging of 5-HT(2c) receptors. Acs Chemical Neuroscience. 4: 261-5. PMID 23421677 DOI: 10.1021/cn300223d  0.96
2013 Diyabalanage HV, Granda ML, Hooker JM. Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer. Cancer Letters. 329: 1-8. PMID 23032720 DOI: 10.1016/j.canlet.2012.09.018  0.96
2013 Weinstein EA, Liu L, Ordonez AA, Wang H, Hooker JM, Tonge PJ, Jain SK. Noninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice Antimicrobial Agents and Chemotherapy. 57: 678. DOI: 10.1128/AAC.02274-12  0.96
2012 Moseley CK, Carlin SM, Neelamegam R, Hooker JM. An efficient and practical radiosynthesis of [11C]temozolomide. Organic Letters. 14: 5872-5. PMID 23151019 DOI: 10.1021/ol302791x  0.96
2012 Lee E, Hooker JM, Ritter T. Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride. Journal of the American Chemical Society. 134: 17456-8. PMID 23061667 DOI: 10.1021/ja3084797  0.96
2012 Weinstein EA, Liu L, Ordonez AA, Wang H, Hooker JM, Tonge PJ, Jain SK. Noninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice. Antimicrobial Agents and Chemotherapy. 56: 6284-90. PMID 23006755 DOI: 10.1128/AAC.01644-12  0.96
2012 Neelamegam R, Ricq EL, Malvaez M, Patnaik D, Norton S, Carlin SM, Hill IT, Wood MA, Haggarty SJ, Hooker JM. Brain-penetrant LSD1 inhibitors can block memory consolidation. Acs Chemical Neuroscience. 3: 120-128. PMID 22754608 DOI: 10.1021/cn200104y  0.96
2012 Riss PJ, Hooker JM, Shea C, Xu Y, Carter P, Warner D, Ferrari V, Kim SW, Aigbirhio FI, Fowler JS, Roesch F. Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 22: 679-82. PMID 22082561 DOI: 10.1016/j.bmcl.2011.10.053  0.96
2012 Ran C, Zhang Z, Hooker J, Moore A. In vivo photoactivation without "light": use of Cherenkov radiation to overcome the penetration limit of light. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 14: 156-62. PMID 21538154 DOI: 10.1007/s11307-011-0489-z  0.96
2011 Lee E, Kamlet AS, Powers DC, Neumann CN, Boursalian GB, Furuya T, Choi DC, Hooker JM, Ritter T. A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging. Science (New York, N.Y.). 334: 639-42. PMID 22053044 DOI: 10.1126/science.1212625  0.96
2011 Behrens CR, Hooker JM, Obermeyer AC, Romanini DW, Katz EM, Francis MB. Rapid chemoselective bioconjugation through oxidative coupling of anilines and aminophenols. Journal of the American Chemical Society. 133: 16398-401. PMID 21919497 DOI: 10.1021/ja2033298  0.96
2011 Reid AE, Kim SW, Seiner B, Fowler FW, Hooker J, Ferrieri R, Babst B, Fowler JS. Radiosynthesis of C-11 labeled auxin (3-indolyl[1- 11C]acetic acid) and its derivatives from gramine Journal of Labelled Compounds and Radiopharmaceuticals. 54: 433-437. DOI: 10.1002/jlcr.1894  0.96
2010 Hooker JM, Kim SW, Alexoff D, Xu Y, Shea C, Reid A, Volkow N, Fowler JS. Histone deacetylase inhibitor, MS-275, exhibits poor brain penetration: PK studies of [C]MS-275 using Positron Emission Tomography. Acs Chemical Neuroscience. 1: 65-73. PMID 20657706 DOI: 10.1021/cn9000268  0.96
2010 Hooker JM, Kim SW, Reibel AT, Alexoff D, Xu Y, Shea C. Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates. Bioorganic & Medicinal Chemistry. 18: 7739-45. PMID 20451398 DOI: 10.1016/j.bmc.2010.04.039  0.96
2010 Schönberger M, Leggett C, Kim SW, Hooker JM. Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography. Bioorganic & Medicinal Chemistry Letters. 20: 3103-6. PMID 20400305 DOI: 10.1016/j.bmcl.2010.03.108  0.96
2010 Liu L, Xu Y, Shea C, Fowler JS, Hooker JM, Tonge PJ. Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons. Journal of Medicinal Chemistry. 53: 2882-91. PMID 20205479 DOI: 10.1021/jm901858n  0.96
2010 Biegon A, Kim SW, Logan J, Hooker JM, Muench L, Fowler JS. Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons. Biological Psychiatry. 67: 774-7. PMID 20188349 DOI: 10.1016/j.biopsych.2010.01.004  0.96
2010 Hooker JM. Modular strategies for PET imaging agents. Current Opinion in Chemical Biology. 14: 105-11. PMID 19880343 DOI: 10.1016/j.cbpa.2009.10.005  0.96
2009 Hooker JM, Munro TA, Béguin C, Alexoff D, Shea C, Xu Y, Cohen BM. Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence. Neuropharmacology. 57: 386-91. PMID 19591852 DOI: 10.1016/j.neuropharm.2009.06.044  0.96
2009 Riss PJ, Hooker JM, Alexoff D, Kim SW, Fowler JS, Rösch F. [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies. Bioorganic & Medicinal Chemistry Letters. 19: 4343-5. PMID 19525112 DOI: 10.1016/j.bmcl.2009.05.090  0.96
2009 Schiffer WK, Liebling CN, Reiszel C, Hooker JM, Brodie JD, Dewey SL. Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6176-85. PMID 19439595 DOI: 10.1523/JNEUROSCI.5221-08.2009  0.96
2009 Hooker JM, Reibel AT, Hill SM, Schueller MJ, Fowler JS. One-pot, direct incorporation of [11C]CO2 into carbamates. Angewandte Chemie (International Ed. in English). 48: 3482-5. PMID 19350593 DOI: 10.1002/anie.200900112  0.96
2009 Kim SW, Biegon A, Katsamanis ZE, Ehrlich CW, Hooker JM, Shea C, Muench L, Xu Y, King P, Carter P, Alexoff DL, Fowler JS. Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase. Nuclear Medicine and Biology. 36: 323-34. PMID 19324278 DOI: 10.1016/j.nucmedbio.2008.12.013  0.96
2009 Reid AE, Hooker J, Shumay E, Logan J, Shea C, Kim SW, Collins S, Xu Y, Volkow N, Fowler JS. Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain. Nuclear Medicine and Biology. 36: 247-58. PMID 19324270 DOI: 10.1016/j.nucmedbio.2008.12.005  0.96
2009 Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, Wang GJ, Jayne M, Hooker JM, Wong C, Hubbard B, Carter P, Warner D, King P, Shea C, et al. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. Jama. 301: 1148-54. PMID 19293415 DOI: 10.1001/jama.2009.351  0.96
2009 Hooker JM, Patel V, Kothari S, Schiffer WK. Metabolic changes in the rodent brain after acute administration of salvinorin A. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 11: 137-43. PMID 19132449 DOI: 10.1007/s11307-008-0192-x  0.96
2008 Hooker JM, Schönberger M, Schieferstein H, Fowler JS. A simple, rapid method for the preparation of [11C]formaldehyde. Angewandte Chemie (International Ed. in English). 47: 5989-92. PMID 18604787 DOI: 10.1002/anie.200800991  0.96
2008 Hooker JM, O'Neil JP, Romanini DW, Taylor SE, Francis MB. Genome-free viral capsids as carriers for positron emission tomography radiolabels. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 10: 182-91. PMID 18437498 DOI: 10.1007/s11307-008-0136-5  0.96
2008 Hooker JM, Xu Y, Schiffer W, Shea C, Carter P, Fowler JS. Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans. Neuroimage. 41: 1044-50. PMID 18434204 DOI: 10.1016/j.neuroimage.2008.03.003  0.96
2008 Datta A, Hooker JM, Botta M, Francis MB, Aime S, Raymond KN. High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: nanosized MRI contrast agents. Journal of the American Chemical Society. 130: 2546-52. PMID 18247608 DOI: 10.1021/ja0765363  0.96
2007 Hooker JM, Datta A, Botta M, Raymond KN, Francis MB. Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Nano Letters. 7: 2207-10. PMID 17630809 DOI: 10.1021/nl070512c  0.96
2007 Kovacs EW, Hooker JM, Romanini DW, Holder PG, Berry KE, Francis MB. Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system. Bioconjugate Chemistry. 18: 1140-7. PMID 17602681 DOI: 10.1021/bc070006e  0.96
2007 Johnson HR, Hooker JM, Francis MB, Clark DS. Solubilization and stabilization of bacteriophage MS2 in organic solvents Biotechnology and Bioengineering. 97: 224-234. PMID 17099911 DOI: 10.1002/bit.21245  0.96
2006 Hooker JM, Esser-Kahn AP, Francis MB. Modification of aniline containing proteins using an oxidative coupling strategy. Journal of the American Chemical Society. 128: 15558-9. PMID 17147343 DOI: 10.1021/ja064088d  0.96
2004 Hooker JM, Kovacs EW, Francis MB. Interior Surface Modification of Bacteriophage MS2 Journal of the American Chemical Society. 126: 3718-3719. PMID 15038717 DOI: 10.1021/ja031790q  0.96
2003 Montero G, Hinks D, Hooker J. Reducing problems of cyclic trimer deposits in supercritical carbon dioxide polyester dyeing machinery Journal of Supercritical Fluids. 26: 47-54. DOI: 10.1016/S0896-8446(02)00187-0  0.96
2003 Hooker J, Hinks D, Montero G, Icherenska M. Enzyme-catalyzed hydrolysis of poly(ethylene terephthalate) cyclic trimer Journal of Applied Polymer Science. 89: 2545-2552. DOI: 10.1002/app.11963  0.96
2003 Hooker J, Hinks D, Freeman H. Synthesis, properties and application of four new 1:2 aluminium-complexed azo dyes Coloration Technology. 119: 41-47.  0.96
2002 Hooker J, Hinks D, Montero G, Conlee C. Synthesis of N,N-diethyl-N-4-[(E)-(4-nitrophenyl)diazenyl]phenyl amine via in situ diazotisation and coupling in supercritical carbon dioxide Coloration Technology. 118: 273-276.  0.96
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