Jacob Matthew Hooker, Ph.D. - Publications

Affiliations: 
1998-2002 Chemistry  North Carolina State University, Raleigh, NC 
 1998-2002 Textile Chemistry North Carolina State University, Raleigh, NC 
 2002-2007 Chemistry University of California, Berkeley, Berkeley, CA 
 2007-2012 Medical Brookhaven National Laboratory, Upton, NY, United States 
 2009- Radiology Harvard Medical School, Boston, MA, United States 
 2009- Martinos Center for Biomedical Imaging Massachusetts General Hospital, Boston, MA 
Area:
positron emission tomography, radiotracer chemistry, epigenetics, neuroscience, neurotransmitters
Website:
http://hookerlab.martinos.org/

200 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Alshelh Z, Brusaferri L, Saha A, Morrissey E, Knight P, Kim M, Zhang Y, Hooker JM, Albrecht D, Torrado-Carvajal A, Placzek MS, Akeju O, Price J, Edwards RR, Lee J, et al. Neuro-immune signatures in chronic low back pain subtypes. Brain : a Journal of Neurology. PMID 34528069 DOI: 10.1093/brain/awab336  1
2021 Guo M, Bakhoda A, Gao ZG, Ramsey JM, Li Y, O'Conor KA, Kelleher AC, Eisenberg SM, Kang Y, Yan X, Javdan C, Fowler JS, Rice KC, Hooker JM, Jacobson KA, et al. Discovery of Highly Potent Adenosine A Receptor Agonists: Targeting Positron Emission Tomography Probes. Acs Chemical Neuroscience. PMID 34469110 DOI: 10.1021/acschemneuro.1c00397  1
2021 Hooker JM. FDA Approval of Aducanumab Divided the Community but Also Connected and United It. Acs Chemical Neuroscience. PMID 34228436 DOI: 10.1021/acschemneuro.1c00393  0.01
2021 Sander CY, Bovo S, Torrado-Carvajal A, Albrecht D, Deng H, Napadow V, Price JC, Hooker JM, Loggia ML. [C]PBR28 radiotracer kinetics are not driven by alterations in cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X211023387. PMID 34159823 DOI: 10.1177/0271678X211023387  1
2021 de Laat B, Kling YE, Schroyen G, Ooms M, Hooker JM, Bormans G, Van Laere K, Ceccarini J. Effects of chronic voluntary alcohol consumption on PDE10A availability: a longitudinal behavioral and [F]JNJ42259152 PET study in rats. European Journal of Nuclear Medicine and Molecular Imaging. PMID 34142214 DOI: 10.1007/s00259-021-05448-3  1
2021 de Laat B, Kling YE, Schroyen G, Ooms M, Hooker JM, Bormans G, Van Laere K, Ceccarini J. Effects of chronic voluntary alcohol consumption on PDE10A availability: a longitudinal behavioral and [F]JNJ42259152 PET study in rats. European Journal of Nuclear Medicine and Molecular Imaging. PMID 34142214 DOI: 10.1007/s00259-021-05448-3  1
2021 Hooker JM. A Reflection on Juneteenth and the Diversity of Our Chemical Neuroscience Community. Acs Chemical Neuroscience. PMID 34115487 DOI: 10.1021/acschemneuro.1c00378  0.01
2021 Lindsley CW, Hooker JM, Liotta DC. Giving Credit Where Credit Is Due: Properly Citing Relevant Prior Art. Acs Medicinal Chemistry Letters. 12: 669. PMID 34055203 DOI: 10.1021/acsmedchemlett.1c00194  1
2021 Babu S, Hightower BG, Chan J, Zürcher NR, Kivisäkk P, Tseng CJ, Sanders DL, Robichaud A, Banno H, Evora A, Ashokkumar A, Pothier L, Paganoni S, Chew S, Dojillo J, ... ... Hooker JM, et al. Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial. Neuroimage. Clinical. 30: 102672. PMID 34016561 DOI: 10.1016/j.nicl.2021.102672  1
2021 Lindsley CW, Hooker JM, Liotta DC. Giving Credit Where Credit Is Due: Properly Citing Relevant Prior Art. Journal of Medicinal Chemistry. PMID 33899467 DOI: 10.1021/acs.jmedchem.1c00634  1
2021 Lindsley CW, Hooker JM, Liotta DC. Giving Credit Where Credit Is Due: Properly Citing Relevant Prior Art. Acs Chemical Neuroscience. PMID 33899459 DOI: 10.1021/acschemneuro.1c00208  1
2021 Zürcher NR, Roberts VHJ, Schabel MC, Edlow AG, Hooker JM, Lo JO. Imaging Epigenetics of Prenatal THC. Acs Chemical Neuroscience. PMID 33852273 DOI: 10.1021/acschemneuro.1c00176  1
2021 Makary MM, Weerasekara A, Rodham H, Hightower BG, Tseng CJ, Chan J, Chew S, Paganoni S, Ratai EM, Zürcher NR, Hooker JM, Atassi N, Babu S. Comparison of Two Clinical Upper Motor Neuron Burden Rating Scales in ALS Using Quantitative Brain Imaging. Acs Chemical Neuroscience. PMID 33576234 DOI: 10.1021/acschemneuro.0c00772  1
2021 Zürcher NR, Walsh EC, Phillips RD, Cernasov PM, Tseng CJ, Dharanikota A, Smith E, Li Z, Kinard JL, Bizzell JC, Greene RK, Dillon D, Pizzagalli DA, Izquierdo-Garcia D, Truong K, ... ... Hooker JM, et al. A simultaneous [C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism. Translational Psychiatry. 11: 33. PMID 33431841 DOI: 10.1038/s41398-020-01170-0  1
2021 Hooker JM. Chemical Neuroscience and the Paths to Impact. Acs Chemical Neuroscience. 12: 1. PMID 33401914 DOI: 10.1021/acschemneuro.0c00799  0.01
2020 Gerstner ER, Emblem KE, Yen YF, Dietrich J, Jordan JT, Catana C, Wenchin KL, Hooker JM, Duda DG, Rosen BR, Kalpathy-Cramer J, Jain RK, Batchelor TT. Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients. Neuro-Oncology Advances. 2: vdaa157. PMID 33392506 DOI: 10.1093/noajnl/vdaa157  1
2020 Torrado-Carvajal A, Toschi N, Albrecht DS, Chang K, Akeju O, Kim M, Edwards RR, Zhang Y, Hooker JM, Duggento A, Kalpathy-Cramer J, Napadow V, Loggia ML. Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain. Pain. PMID 33065737 DOI: 10.1097/j.pain.0000000000002108  1
2020 Dalton RM, Krishnan HS, Parker VS, Catanese M, Hooker JM. The coevolution of atomic resolution and whole-brain imaging for tau neurofibrillary tangles. Acs Chemical Neuroscience. PMID 32786315 DOI: 10.1021/Acschemneuro.0C00426  1
2020 Katsumi Y, Racine AM, Torrado-Carvajal A, Loggia ML, Hooker JM, Greve DN, Hightower BG, Catana C, Cavallari M, Arnold SE, Fong TG, Vasunilashorn SM, Marcantonio ER, Schmitt EM, Xu G, et al. The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [C]PBR28 binding and exploration of its link to post-operative delirium. Neuroimage. Clinical. 27: 102346. PMID 32712451 DOI: 10.1016/J.Nicl.2020.102346  1
2020 Antonelli R, Jiménez C, Riley M, Servidei T, Riccardi R, Soriano A, Roma J, Martínez-Saez E, Martini M, Ruggiero A, Moreno L, Sánchez de Toledo J, Gallego S, Bové J, Hooker JM, et al. CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models. Cancers. 12. PMID 32708733 DOI: 10.3390/Cancers12071922  0.01
2020 Downer OM, Marcus REG, Zürcher NR, Hooker JM. Tracing the History of the Human Translocator Protein to Recent Neurodegenerative and Psychiatric Imaging. Acs Chemical Neuroscience. PMID 32662626 DOI: 10.1021/Acschemneuro.0C00362  1
2020 Tseng CJ, Gilbert TM, Catanese MC, Hightower BG, Peters AT, Parmar AJ, Kim M, Wang C, Roffman JL, Brown HE, Perlis RH, Zürcher NR, Hooker JM. In vivo human brain expression of histone deacetylases in bipolar disorder. Translational Psychiatry. 10: 224. PMID 32641695 DOI: 10.1038/S41398-020-00911-5  1
2020 Koole M, Van Weehaeghe D, Serdons K, Herbots M, Cawthorne C, Celen S, Schroeder FA, Hooker JM, Bormans G, de Hoon J, Kranz JE, Van Laere K, Gilbert TM. Clinical validation of the novel HDAC6 radiotracer [F]EKZ-001 in the human brain. European Journal of Nuclear Medicine and Molecular Imaging. PMID 32638097 DOI: 10.1007/S00259-020-04891-Y  1
2020 Parmar A, Zürcher NR, Hooker JM. Time Will Tell the Utility of Biomarkers. Acs Chemical Neuroscience. PMID 32463674 DOI: 10.1021/Acschemneuro.0C00238  1
2020 Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA. Extra-axial inflammatory signal in parameninges in migraine with visual aura. Annals of Neurology. PMID 32239542 DOI: 10.1002/Ana.25731  1
2020 Van Weehaeghe D, Babu S, De Vocht J, Zurcher NR, Chew S, Tseng CJ, Loggia M, Koole M, Rezaei A, Schramm G, Van Damme P, Hooker JM, Van Laere K, Atassi N. Moving towards multicenter therapeutic trials in ALS: feasibility of data pooling using different TSPO positron emission tomography (PET) radioligands. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 32169920 DOI: 10.2967/Jnumed.119.241059  1
2020 Celen S, Rokka J, Gilbert TM, Koole M, Vermeulen I, Serdons K, Schroeder FA, Wagner FF, Bleeser T, Hightower BG, Hu J, Rahal D, Beyzavi MH, Vanduffel W, Van Laere K, ... ... Hooker JM, et al. Translation of HDAC6 PET imaging using [18F]EKZ-001 - cGMP production and measurement of HDAC6 target occupancy in NHPs. Acs Chemical Neuroscience. PMID 32159328 DOI: 10.1021/Acschemneuro.0C00074  1
2020 Zürcher NR, Loggia ML, Mullett JE, Tseng C, Bhanot A, Richey L, Hightower BG, Wu C, Parmar AJ, Butterfield RI, Dubois JM, Chonde DB, Izquierdo-Garcia D, Wey HY, Catana C, ... ... Hooker JM, et al. [C]PBR28 MR-PET imaging reveals lower regional brain expression of translocator protein (TSPO) in young adult males with autism spectrum disorder. Molecular Psychiatry. PMID 32076115 DOI: 10.1038/S41380-020-0682-Z  1
2019 Osko JD, Porter NJ, Reddy PAN, Xiao YC, Rokka J, Jung M, Hooker JM, Salvino JM, Christianson DW. Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. Journal of Medicinal Chemistry. PMID 31793776 DOI: 10.1021/Acs.Jmedchem.9B01540  1
2019 L 'Estrade ET, Shalgunov V, Edgar FG, Strebl-Bantillo MG, Xiong M, Crestey F, Neelamegam R, Dyssegaard A, Lehel S, Erlandsson M, Ohlsson T, Hooker JM, Knudsen GM, Herth MM, Hansen HD. Radiosynthesis and preclinical evaluation of [ C]Cimbi-701 - Towards the imaging of cerebral 5-HT receptors. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 31674045 DOI: 10.1002/Jlcr.3808  1
2019 Gerstner E, Emblem KE, Chang K, Vakulenko-Lagun B, Yen YF, Beers AL, Dietrich J, Plotkin SR, Catana C, Hooker JM, Duda DG, Rosen B, Kalpathy-Cramer J, Jain RK, Batchelor T. Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31558474 DOI: 10.1158/1078-0432.Ccr-19-1739  1
2019 Gilbert TM, Zürcher NR, Catanese MC, Tseng CJ, Di Biase MA, Lyall AE, Hightower BG, Parmar AJ, Bhanot A, Wu CJ, Hibert ML, Kim M, Mahmood U, Stufflebeam SM, Schroeder FA, ... ... Hooker JM, et al. Neuroepigenetic signatures of age and sex in the living human brain. Nature Communications. 10: 2945. PMID 31270332 DOI: 10.1038/S41467-019-11031-0  1
2019 Dios AM, Babu S, Granucci EJ, Mueller KA, Mills AN, Alshikho MJ, Zürcher NR, Cernasov P, Gilbert TM, Glass JD, Berry JD, Atassi N, Hooker JM, Sadri-Vakili G. Class I and II HDAC expression is not altered in human amyotrophic lateral sclerosis: Neuropathological and PET molecular neuroimaging evidence. Muscle & Nerve. PMID 31241177 DOI: 10.1002/Mus.26620  1
2019 Hooker JM, Carson RE. Human Positron Emission Tomography Neuroimaging. Annual Review of Biomedical Engineering. 21: 551-581. PMID 31167104 DOI: 10.1146/Annurev-Bioeng-062117-121056  0.01
2019 Albrecht DS, Kim M, Akeju O, Torrado-Carvajal A, Edwards RR, Zhang Y, Bergan C, Protsenko E, Kucyi A, Wasan AD, Hooker JM, Napadow V, Loggia ML. The neuroinflammatory component of negative affect in patients with chronic pain. Molecular Psychiatry. PMID 31138890 DOI: 10.1038/S41380-019-0433-1  1
2019 Smith CJ, Bhanot A, Norman E, Mullett JE, Bilbo SD, McDougle CJ, Zürcher NR, Hooker JM. A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. PMID 31004246 DOI: 10.1007/S10803-019-04010-3  1
2019 Lindsley CW, Abbott C, Andrews AM, Hooker JM, Zhou J. Editors' Favorites: Best of 2018. Acs Chemical Neuroscience. 10: 1-4. PMID 30990663 DOI: 10.1021/Acschemneuro.8B00717  1
2019 Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Loggia ML, Hadjikhani N. Imaging of neuroinflammation in migraine with aura: A [C]PBR28 PET/MRI study. Neurology. PMID 30918090 DOI: 10.1212/Wnl.0000000000007371  1
2018 Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, ... ... Hooker JM, et al. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. The Journal of Clinical Investigation. PMID 30530989 DOI: 10.1172/Jci123743  1
2018 Paganoni S, Alshikho MJ, Luppino S, Chan J, Pothier L, Schoenfeld D, Andres PL, Babu S, Zürcher NR, Loggia ML, Barry RL, Luotti S, Nardo G, Trolese MC, Pantalone S, ... ... Hooker J, et al. A Pilot Trial of RNS60 in Amyotrophic Lateral Sclerosis. Muscle & Nerve. PMID 30458059 DOI: 10.1002/Mus.26385  1
2018 Strebl MG, Yang J, Isaacs L, Hooker JM. Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET. Molecular Imaging. 17: 1536012118799838. PMID 30354934 DOI: 10.1177/1536012118799838  1
2018 Sander CY, Schoenberger M, Hooker JM. Response to Comment on "In Vivo [F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates". Acs Chemical Neuroscience. PMID 30346705 DOI: 10.1021/Acschemneuro.8B00423  1
2018 Albrecht DS, Forsberg A, Sandstrom A, Bergan C, Kadetoff D, Protsenko E, Lampa J, Lee YC, Höglund CO, Catana C, Cervenka S, Akeju O, Lekander M, Cohen G, Halldin C, ... ... Hooker JM, et al. Brain glial activation in fibromyalgia - a multi-site positron emission tomography investigation. Brain, Behavior, and Immunity. PMID 30223011 DOI: 10.1016/J.Bbi.2018.09.018  1
2018 Placzek MS, Schroeder FA, Che T, Wey HY, Neelamegam R, Wang C, Roth BL, Hooker JM. Discrepancies in kappa opioid agonist binding revealed through PET imaging. Acs Chemical Neuroscience. PMID 30212182 DOI: 10.1021/Acschemneuro.8B00293  1
2018 Porter NJ, Osko JD, Diedrich D, Kurz T, Hooker JM, Hansen FK, Christianson DW. Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. Journal of Medicinal Chemistry. PMID 30118224 DOI: 10.1021/Acs.Jmedchem.8B01013  1
2018 Larimer BM, Dubois F, Bloch E, Nesti S, Placzek M, Zadra G, Hooker JM, Loda M, Mahmood U. Specific F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models is Facilitated by Pre-Binding to Sex Hormone Binding Globulin. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 29853654 DOI: 10.2967/Jnumed.118.208785  0.01
2018 Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Reynolds B, Pijanowski O, Chonde DB, Izquierdo Garcia D, Mainero C, Catana C, Chan J, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated MRI and [ C]-PBR28 PET Imaging in Amyotrophic Lateral sclerosis. Annals of Neurology. PMID 29740862 DOI: 10.1002/Ana.25251  1
2018 Lois C, Gonzalez I, Izquierdo-Garcia D, Zurcher NR, Wilkens P, Loggia ML, Hooker JM, Rosas HD. Neuroinflammation in Huntington's disease: new insights with C-PBR28 PET/MRI. Acs Chemical Neuroscience. PMID 29719953 DOI: 10.1021/Acschemneuro.8B00072  1
2018 Albrecht DS, Granziera C, Hooker JM, Loggia ML. Correction to In Vivo Imaging of Human Neuroinflammation. Acs Chemical Neuroscience. PMID 29708334 DOI: 10.1021/Acschemneuro.8B00188  1
2018 Liu W, Huang X, Placzek MS, Krska SW, McQuade P, Hooker JM, Groves JT. Site-selective F fluorination of unactivated C-H bonds mediated by a manganese porphyrin. Chemical Science. 9: 1168-1172. PMID 29675161 DOI: 10.1039/C7Sc04545J  1
2018 Weiwer M, Xu Q, Gale JP, Lewis M, Campbell AJ, Schroeder FA, Van de Bittner GC, Walk M, Amaya A, Su P, Đorđević L, Sacher JR, Skepner A, Fei D, Dennehy K, ... ... Hooker JM, et al. Functionally biased D2R antagonists: Targeting the β-arrestin pathway to improve antipsychotic treatment. Acs Chemical Biology. PMID 29485852 DOI: 10.1021/Acschembio.8B00168  1
2018 Albrecht D, Ahmed S, Kettner N, Borra R, Cohen-Adad J, Deng H, Houle T, Opalacz A, Roth S, Melo MV, Chen L, Mao J, Hooker J, Loggia ML, Zhang Y. Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients. Pain. PMID 29419657 DOI: 10.1097/J.Pain.0000000000001171  1
2018 Lindsley CW, Cunningham KA, Hooker JM, Andrews AM. Editors' Favorites of 2017. Acs Chemical Neuroscience. 9: 1-4. PMID 29338186 DOI: 10.1021/Acschemneuro.8B00001  1
2018 Krishnan HS, Bernard-Gauthier V, Placzek MS, Dahl K, Narayanaswami V, Livni E, Chen Z, Yang J, Collier TL, Ran C, Hooker JM, Liang SH, Vasdev N. A metal protein-attenuating compound for PET neuroimaging: Synthesis and preclinical evaluation of [11C]PBT2. Molecular Pharmaceutics. PMID 29298483 DOI: 10.1021/Acs.Molpharmaceut.7B00936  1
2018 Linnman C, Catana C, Petkov MP, Chonde DB, Becerra L, Hooker J, Borsook D. Molecular and functional PET-fMRI measures of placebo analgesia in episodic migraine: Preliminary findings. Neuroimage. Clinical. 17: 680-690. PMID 29255671 DOI: 10.1016/J.Nicl.2017.11.011  1
2018 Paganoni S, Alshikho MJ, Zürcher NR, Cernasov P, Babu S, Loggia ML, Chan J, Chonde DB, Garcia DI, Catana C, Mainero C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Imaging of glia activation in people with primary lateral sclerosis. Neuroimage. Clinical. 17: 347-353. PMID 29159046 DOI: 10.1016/J.Nicl.2017.10.024  1
2017 Schoenberger M, Schroeder FA, Placzek MS, Carter RL, Rosen BR, Hooker JM, Sander CY. In vivo [(18)F]GE-179 brain signal does not show NMDA-specific modulation with drug challenges in rodents and non-human primates. Acs Chemical Neuroscience. PMID 29050469 DOI: 10.1021/Acschemneuro.7B00327  1
2017 Van de Bittner GC, Van de Bittner KC, Wey HY, Rowe W, Dharanipragada R, Ying X, Hurst W, Giovanni A, Alving K, Gupta A, Hoekman J, Hooker JM. Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A. Acs Chemical Neuroscience. PMID 29035509 DOI: 10.1021/Acschemneuro.7B00357  1
2017 Strebl MG, Campbell AJ, Zhao WN, Schroeder FA, Riley MM, Chindavong PS, Morin TM, Haggarty SJ, Wagner FF, Ritter T, Hooker JM. HDAC6 Brain Mapping with [(18)F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination. Acs Central Science. 3: 1006-1014. PMID 28979942 DOI: 10.1021/Acscentsci.7B00274  1
2017 Beyzavi MH, Mandal D, Strebl MG, Neumann CN, D'Amato EM, Chen J, Hooker JM, Ritter T. (18)F-Deoxyfluorination of Phenols via Ru π-Complexes. Acs Central Science. 3: 944-948. PMID 28979935 DOI: 10.1021/Acscentsci.7B00195  1
2017 Hansen HD, Mandeville JB, Sander CY, Hooker JM, Catana C, Rosen BR, Knudsen GM. Functional characterization of 5-HT1B receptor drugs in non-human primates using simultaneous PET-MR. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28972127 DOI: 10.1523/Jneurosci.1971-17.2017  1
2017 Albrecht DS, Normandin MD, Shcherbinin S, Wooten DW, Schwarz AJ, Zurcher NR, Barth VN, Guehl NJ, Johnson-Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker JM, Loggia ML. Pseudo-reference regions for glial imaging with (11)C-PBR28: investigation in two clinical cohorts. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28818984 DOI: 10.2967/Jnumed.116.178335  1
2017 Sander CY, Mandeville JB, Wey HY, Catana C, Hooker JM, Rosen BR. Effects of flow changes on radiotracer binding: Simultaneous measurement of neuroreceptor binding and cerebral blood flow modulation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17725418. PMID 28816571 DOI: 10.1177/0271678X17725418  1
2017 Kanthan M, Cumming P, Hooker JM, Vasdev N. Classics in Neuroimaging: Imaging the Dopaminergic Pathway with PET. Acs Chemical Neuroscience. PMID 28719177 DOI: 10.1021/Acschemneuro.7B00252  1
2017 Ma L, Placzek MS, Hooker JM, Vasdev N, Liang SH. [(11)C]Cyanation of arylboronic acids in aqueous solutions. Chemical Communications (Cambridge, England). PMID 28580477 DOI: 10.1039/C7Cc02886E  1
2017 Zhao W, Lee HG, Buchwald SL, Hooker JM. Direct (11)CN-Labeling of Unprotected Peptides via Palladium-Mediated Sequential Cross-Coupling Reactions. Journal of the American Chemical Society. 139: 7152-7155. PMID 28502164 DOI: 10.1021/Jacs.7B02761  1
2017 Zhu H, Xue X, Wang E, Wallack M, Na H, Hooker JM, Kowall N, Tao Q, Stein TD, Wolozin B, Qiu WQ. Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease. Neuropharmacology. PMID 28363773 DOI: 10.1016/J.Neuropharm.2017.03.030  0.01
2017 Hu K, Patnaik D, Collier TL, Lee KN, Gao H, Swoyer MR, Rotstein BH, Krishnan HS, Liang SH, Wang J, Yan Z, Hooker JM, Vasdev N, Haggarty SJ, Ngai MY. Development of [(18)F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging. Acs Medicinal Chemistry Letters. 8: 287-292. PMID 28337318 DOI: 10.1021/Acsmedchemlett.6B00405  1
2017 Hooker JM, Strebl MG, Schroeder FA, Wey HY, Ambardekar AV, McKinsey TA, Schoenberger M. Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine. Scientific Reports. 7: 42136. PMID 28205593 DOI: 10.1038/Srep42136  1
2017 Atzil S, Touroutoglou A, Rudy T, Salcedo S, Feldman R, Hooker JM, Dickerson BC, Catana C, Barrett LF. Dopamine in the medial amygdala network mediates human bonding. Proceedings of the National Academy of Sciences of the United States of America. PMID 28193868 DOI: 10.1073/Pnas.1612233114  1
2017 Schuetze KB, Stratton MS, Blakeslee WW, Wempe MF, Wagner FF, Holson EB, Kuo YM, Andrews AJ, Gilbert TM, Hooker JM, McKinsey TA. Overlapping and Divergent Actions of Structurally Distinct HDAC Inhibitors in Cardiac Fibroblasts. The Journal of Pharmacology and Experimental Therapeutics. PMID 28174211 DOI: 10.1124/Jpet.116.237701  1
2017 Fuin N, Pedemonte S, Catalano OA, Izquierdo-Garcia D, Soricelli A, Salvatore M, Heberlein K, Hooker JM, Van Leemput K, Catana C. PET/MR Imaging in the Presence of Metal Implants: Completion of the Attenuation Map from PET Emission Data. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28126884 DOI: 10.2967/Jnumed.116.183343  1
2017 Van de Bittner GC, Riley MM, Cao L, Ehses J, Herrick SP, Ricq EL, Wey HY, O'Neill MJ, Ahmed Z, Murray TK, Smith JE, Wang C, Schroeder FA, Albers MW, Hooker JM. Nasal neuron PET imaging quantifies neuron generation and degeneration. The Journal of Clinical Investigation. PMID 28112682 DOI: 10.1172/Jci89162  1
2017 Lindsley CW, Hooker JM, Cunningham KA, Andrews AM. Editors' Favorites of 2016. Acs Chemical Neuroscience. 8: 1-3. PMID 28095678 DOI: 10.1021/Acschemneuro.6B00461  1
2017 Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, ... ... Hooker J, et al. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nature Communications. 8: 14064. PMID 28091604 DOI: 10.1038/Ncomms14064  1
2016 Herranz E, Hooker JM, Izquierdo-Garcia D, Loggia ML, Mainero C. (11) C-PBR28 increase in multiple sclerosis reflects neuroinflammation. Annals of Neurology. PMID 28032651 DOI: 10.1002/Ana.24865  1
2016 Campbell MG, Mercier J, Genicot C, Gouverneur V, Hooker JM, Ritter T. Bridging the gaps in (18)F PET tracer development. Nature Chemistry. 9: 1-3. PMID 27995923 DOI: 10.1038/Nchem.2693  1
2016 Schroeder FA, Gilbert TM, Feng N, Taillon BD, Volkow ND, Innis RB, Hooker JM, Lipska BK. Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia. Acs Chemical Neuroscience. PMID 27959513 DOI: 10.1021/Acschemneuro.6B00372  1
2016 Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Chonde DB, Izquierdo Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis. Neurology. PMID 27837005 DOI: 10.1212/Wnl.0000000000003427  1
2016 Wang C, Schroeder FA, Hooker JM. Development of New Positron Emission Tomography Radiotracer for BET Imaging. Acs Chemical Neuroscience. PMID 27806195 DOI: 10.1021/Acschemneuro.6B00288  1
2016 Kumar V, Boucher Y, Liu H, Ferreira D, Hooker J, Catana C, Hoover AJ, Ritter T, Jain RK, Guimaraes AR. Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma. Translational Oncology. 9: 431-437. PMID 27751347 DOI: 10.1016/J.Tranon.2016.07.004  1
2016 Herranz E, Giannì C, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Loggia ML, Sloane JA, Madigan N, Izquierdo-Garcia D, Ward N, Mangeat G, Granberg T, Klawiter EC, Catana C, ... Hooker JM, et al. The neuroinflammatory component of gray matter pathology in multiple sclerosis. Annals of Neurology. PMID 27686563 DOI: 10.1002/Ana.24791  1
2016 Ricq EL, Hooker JM, Haggarty SJ. Activity-Dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch. The Journal of Biological Chemistry. PMID 27634040 DOI: 10.1074/Jbc.M116.734426  1
2016 Rotstein BH, Placzek MS, Krishnan HS, Pekošak A, Collier TL, Wang C, Liang SH, Burstein ES, Hooker JM, Vasdev N. Preclinical PET Neuroimaging of [11C]Bexarotene. Molecular Imaging. 15. PMID 27553293 DOI: 10.1177/1536012116663054  1
2016 Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Insights into neuroepigenetics through human histone deacetylase PET imaging. Science Translational Medicine. 8: 351ra106. PMID 27510902 DOI: 10.1126/Scitranslmed.Aaf7551  1
2016 Neumann CN, Hooker JM, Ritter T. Corrigendum: Concerted nucleophilic aromatic substitution with (19)F(-) and (18)F(.) Nature. PMID 27487221 DOI: 10.1038/Nature19311  1
2016 Ricq EL, Hooker JM, Haggarty SJ. Toward Development of Epigenetic Drugs for CNS Disorders: Modulating Neuroplasticity via H3K4 Methylation. Psychiatry and Clinical Neurosciences. PMID 27485392 DOI: 10.1111/Pcn.12426  1
2016 Roffman JL, Tanner AS, Eryilmaz H, Rodriguez-Thompson A, Silverstein NJ, Ho NF, Nitenson AZ, Chonde DB, Greve DN, Abi-Dargham A, Buckner RL, Manoach DS, Rosen BR, Hooker JM, Catana C. Dopamine D1 signaling organizes network dynamics underlying working memory. Science Advances. 2: e1501672. PMID 27386561 DOI: 10.1126/Sciadv.1501672  1
2016 Mandeville JB, Sander CY, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR. A regularized full reference tissue model for PET neuroreceptor mapping. Neuroimage. PMID 27364474 DOI: 10.1016/J.Neuroimage.2016.06.044  1
2016 Neumann CN, Hooker JM, Ritter T. Concerted nucleophilic aromatic substitution with (19)F(-) and (18)F(.) Nature. PMID 27281221 DOI: 10.1038/Nature17667  1
2016 Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J, Minocha J, Valasek MA, Aryafar H, Brenner DA, Sirlin CB, Loomba R. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Alimentary Pharmacology & Therapeutics. PMID 27279429 DOI: 10.1111/Apt.13691  1
2016 Rotstein BH, Liang SH, Placzek MS, Hooker JM, Gee AD, Dollé F, Wilson AA, Vasdev N. (11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals. Chemical Society Reviews. PMID 27276357 DOI: 10.1039/C6Cs00310A  1
2016 Hooker JM. Neuroinflammation: Brain on Fire? Acs Chemical Neuroscience. 7: 415. PMID 27094163 DOI: 10.1021/Acschemneuro.6B00104  1
2016 Hoover AJ, Lazari M, Ren H, Narayanam MK, Murphy JM, van Dam RM, Hooker JM, Ritter T. A Transmetalation Reaction Enables the Synthesis of [(18)F]5-Fluorouracil from [(18)F]Fluoride for Human PET Imaging. Organometallics. 35: 1008-1014. PMID 27087736 DOI: 10.1021/Acs.Organomet.6B00059  1
2016 Albrecht DS, Granziera C, Hooker JM, Loggia ML. In vivo imaging of human neuroinflammation. Acs Chemical Neuroscience. PMID 26985861 DOI: 10.1021/Acschemneuro.6B00056  1
2016 Placzek MS, Zhao W, Wey HY, Morin TM, Hooker JM. PET Neurochemical Imaging Modes. Seminars in Nuclear Medicine. 46: 20-7. PMID 26687854 DOI: 10.1053/J.Semnuclmed.2015.09.001  1
2016 Bittner GCVd, Riley MM, Cao L, Ehses J, Wey H, Neelamegam R, Albers M, Hooker JM. Olfactory Sensory Neuron Monitoring In Alzheimer’S Disease: Toward Human Translation Of A Pet Imaging Agent Alzheimers & Dementia. 12: 122. DOI: 10.1016/J.Jalz.2016.06.197  1
2015 Huang X, Liu W, Hooker JM, Groves JT. Corrigendum: Targeted Fluorination with the Fluoride Ion by Manganese-Catalyzed Decarboxylation. Angewandte Chemie (International Ed. in English). 54: 14215. PMID 26768105 DOI: 10.1002/Anie.201509229  1
2015 Wang C, Placzek MS, Van de Bittner GC, Schroeder FA, Hooker JM. A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography. Acs Chemical Neuroscience. PMID 26694017 DOI: 10.1021/Acschemneuro.5B00293  1
2015 Strebl MG, Wang C, Schroeder FA, Placzek MS, Wey HY, Van de Bittner GC, Neelamegam R, Hooker JM. Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. Acs Chemical Neuroscience. PMID 26675505 DOI: 10.1021/Acschemneuro.5B00297  1
2015 Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, ... Hooker JM, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. Acs Chemical Biology. PMID 26640968 DOI: 10.1021/Acschembio.5B00640  1
2015 Borra RJ, Cho HS, Bowen SL, Attenberger U, Arabasz G, Catana C, Josephson L, Rosen BR, Guimaraes AR, Hooker JM. Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model. Ejnmmi Physics. 2: 6. PMID 26501808 DOI: 10.1186/S40658-015-0109-0  1
2015 Lee SJ, Fowler JS, Alexoff D, Schueller M, Kim D, Nauth A, Weber C, Kim SW, Hooker JM, Ma L, Qu W. An efficient and practical synthesis of [2-(11)C]indole via superfast nucleophilic [(11)C]cyanation and RANEY® Nickel catalyzed reductive cyclization. Organic & Biomolecular Chemistry. PMID 26411301 DOI: 10.1039/C5Ob01654A  1
2015 Sander CY, Hooker JM, Catana C, Rosen BR, Mandeville JB. Imaging Agonist-Induced D2/D3 Receptor Desensitization and Internalization In Vivo with PET/fMRI. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26388148 DOI: 10.1038/Npp.2015.296  1
2015 Wang H, Liu L, Lu Y, Pan P, Hooker JM, Fowler JS, Tonge PJ. Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. PMID 26227776 DOI: 10.1016/J.Bmcl.2015.07.019  1
2015 Placzek MS, Van de Bittner GC, Wey HY, Lukas SE, Hooker JM. Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26058662 DOI: 10.1038/npp.2015.159  1
2015 Giancardo L, Sánchez-Ferro A, Butterworth I, Mendoza CS, Hooker JM. Psychomotor impairment detection via finger interactions with a computer keyboard during natural typing. Scientific Reports. 5: 9678. PMID 25882641 DOI: 10.1038/Srep09678  1
2015 Liang SH, Holland JP, Stephenson NA, Kassenbrock A, Rotstein BH, Daignault CP, Lewis R, Collier L, Hooker JM, Vasdev N. PET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primates. Acs Chemical Neuroscience. 6: 535-41. PMID 25776827 DOI: 10.1021/Acschemneuro.5B00055  1
2015 Wey HY, Wang C, Schroeder FA, Logan J, Price JC, Hooker JM. Kinetic Analysis and Quantification of [¹¹C]Martinostat for in Vivo HDAC Imaging of the Brain. Acs Chemical Neuroscience. 6: 708-15. PMID 25768025 DOI: 10.1021/Acschemneuro.5B00066  1
2015 Huang X, Liu W, Hooker JM, Groves JT. Targeted fluorination with the fluoride ion by manganese-catalyzed decarboxylation. Angewandte Chemie (International Ed. in English). 54: 5241-5. PMID 25736895 DOI: 10.1002/Anie.201500399  1
2015 Zürcher NR, Loggia ML, Lawson R, Chonde DB, Izquierdo-Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28. Neuroimage. Clinical. 7: 409-14. PMID 25685708 DOI: 10.1016/J.Nicl.2015.01.009  1
2015 Zürcher NR, Bhanot A, McDougle CJ, Hooker JM. A systematic review of molecular imaging (PET and SPECT) in autism spectrum disorder: current state and future research opportunities. Neuroscience and Biobehavioral Reviews. 52: 56-73. PMID 25684726 DOI: 10.1016/J.Neubiorev.2015.02.002  1
2015 Loggia ML, Chonde DB, Akeju O, Arabasz G, Catana C, Edwards RR, Hill E, Hsu S, Izquierdo-Garcia D, Ji RR, Riley M, Wasan AD, Zürcher NR, Albrecht DS, Vangel MG, ... Hooker JM, et al. Evidence for brain glial activation in chronic pain patients. Brain : a Journal of Neurology. 138: 604-15. PMID 25582579 DOI: 10.1093/Brain/Awu377  1
2015 Lee HG, Milner PJ, Placzek MS, Buchwald SL, Hooker JM. Virtually instantaneous, room-temperature [(11)C]-cyanation using biaryl phosphine Pd(0) complexes. Journal of the American Chemical Society. 137: 648-51. PMID 25565277 DOI: 10.1021/Ja512115S  1
2015 McDougle CJ, Landino SM, Vahabzadeh A, O'Rourke J, Zurcher NR, Finger BC, Palumbo ML, Helt J, Mullett JE, Hooker JM, Carlezon WA. Toward an immune-mediated subtype of autism spectrum disorder. Brain Research. 1617: 72-92. PMID 25445995 DOI: 10.1016/J.Brainres.2014.09.048  1
2014 Catana C, Chonde DB, Chen KT, Izquierdo-Garcia D, Bowen S, Hooker J, Roffman J. Combined MR-assisted motion and partial volume effects corrections - impact on PET data quantification. Ejnmmi Physics. 1: A38. PMID 26501625 DOI: 10.1186/2197-7364-1-S1-A38  1
2014 Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, et al. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 3: e04499. PMID 25432022 DOI: 10.7554/Elife.04499  1
2014 Van de Bittner GC, Ricq EL, Hooker JM. A philosophy for CNS radiotracer design. Accounts of Chemical Research. 47: 3127-34. PMID 25272291 DOI: 10.1021/Ar500233S  1
2014 Wang H, Lu Y, Liu L, Kim SW, Hooker JM, Fowler JS, Tonge PJ. Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus. European Journal of Medicinal Chemistry. 88: 66-73. PMID 25217335 DOI: 10.1016/J.Ejmech.2014.09.008  1
2014 Wang C, Schroeder FA, Wey HY, Borra R, Wagner FF, Reis S, Kim SW, Holson EB, Haggarty SJ, Hooker JM. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. Journal of Medicinal Chemistry. 57: 7999-8009. PMID 25203558 DOI: 10.1021/Jm500872P  1
2014 Schroeder FA, Wang C, Van de Bittner GC, Neelamegam R, Takakura WR, Karunakaran A, Wey HY, Reis SA, Gale J, Zhang YL, Holson EB, Haggarty SJ, Hooker JM. PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. Acs Chemical Neuroscience. 5: 1055-62. PMID 25188794 DOI: 10.1021/Cn500162J  1
2014 Wey HY, Catana C, Hooker JM, Dougherty DD, Knudsen GM, Wang DJ, Chonde DB, Rosen BR, Gollub RL, Kong J. Simultaneous fMRI-PET of the opioidergic pain system in human brain. Neuroimage. 102: 275-82. PMID 25107855 DOI: 10.1016/J.Neuroimage.2014.07.058  1
2014 Diyabalanage HV, Van de Bittner GC, Ricq EL, Hooker JM. A chemical strategy for the cell-based detection of HDAC activity. Acs Chemical Biology. 9: 1257-62. PMID 25056147 DOI: 10.1021/Cb500248R  1
2014 Rotstein BH, Wey HY, Shoup TM, Wilson AA, Liang SH, Hooker JM, Vasdev N. PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates. Molecular Pharmaceutics. 11: 3832-8. PMID 25004399 DOI: 10.1021/Mp500316H  1
2014 Rotstein BH, Hooker JM, Woo J, Collier TL, Brady TJ, Liang SH, Vasdev N. Synthesis of [(11)C]Bexarotene by Cu-Mediated [(11)C]Carbon Dioxide Fixation and Preliminary PET Imaging. Acs Medicinal Chemistry Letters. 5: 668-72. PMID 24944741 DOI: 10.1021/Ml500065Q  1
2014 Villien M, Wey HY, Mandeville JB, Catana C, Polimeni JR, Sander CY, Zürcher NR, Chonde DB, Fowler JS, Rosen BR, Hooker JM. Dynamic functional imaging of brain glucose utilization using fPET-FDG. Neuroimage. 100: 192-9. PMID 24936683 DOI: 10.1016/J.Neuroimage.2014.06.025  1
2014 Ren H, Wey HY, Strebl M, Neelamegam R, Ritter T, Hooker JM. Synthesis and imaging validation of [¹⁸F]MDL100907 enabled by Ni-mediated fluorination. Acs Chemical Neuroscience. 5: 611-5. PMID 24845956 DOI: 10.1021/Cn500078E  1
2014 Granda ML, Schroeder FA, Borra RH, Schauer N, Aisaborhale E, Guimaraes AR, Hooker JM. First D1-like receptor PET imaging of the rat and primate kidney: implications for human disease monitoring. American Journal of Physiology. Renal Physiology. 307: F116-21. PMID 24808534 DOI: 10.1152/Ajprenal.00111.2014  1
2014 Seo YJ, Kang Y, Muench L, Reid A, Caesar S, Jean L, Wagner F, Holson E, Haggarty SJ, Weiss P, King P, Carter P, Volkow ND, Fowler JS, Hooker JM, et al. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. Acs Chemical Neuroscience. 5: 588-96. PMID 24780082 DOI: 10.1021/Cn500021P  1
2014 Huang X, Liu W, Ren H, Neelamegam R, Hooker JM, Groves JT. Late stage benzylic C-H fluorination with [¹⁸F]fluoride for PET imaging. Journal of the American Chemical Society. 136: 6842-5. PMID 24766544 DOI: 10.1021/Ja5039819  1
2014 Pan P, Knudson SE, Bommineni GR, Li HJ, Lai CT, Liu N, Garcia-Diaz M, Simmerling C, Patil SS, Slayden RA, Tonge PJ. Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy. Chemmedchem. 9: 776-91. PMID 24616444 DOI: 10.1002/Cmdc.201300429  1
2014 Neelamegam R, Hellenbrand T, Schroeder FA, Wang C, Hooker JM. Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization. Journal of Medicinal Chemistry. 57: 1488-94. PMID 24491146 DOI: 10.1021/Jm401802F  1
2014 Wang C, Schroeder FA, Hooker JM. Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniques. Neuroscience. 264: 186-97. PMID 24051365 DOI: 10.1016/J.Neuroscience.2013.09.018  1
2014 Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Ramirez VC, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, et al. Author response: Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness Elife. DOI: 10.7554/Elife.04499.020  1
2013 Wang C, Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y, Neelamegam R, Schroeder FA, Holson EB, Haggarty SJ, Hooker JM. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. American Journal of Nuclear Medicine and Molecular Imaging. 4: 29-38. PMID 24380043  1
2013 Seo YJ, Muench L, Reid A, Chen J, Kang Y, Hooker JM, Volkow ND, Fowler JS, Kim SW. Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain. Bioorganic & Medicinal Chemistry Letters. 23: 6700-5. PMID 24210501 DOI: 10.1016/J.Bmcl.2013.10.038  1
2013 Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. Plos One. 8: e71323. PMID 23967191 DOI: 10.1371/Journal.Pone.0071323  1
2013 Wang C, Wilson CM, Moseley CK, Carlin SM, Hsu S, Arabasz G, Schroeder FA, Sander CY, Hooker JM. Evaluation of potential PET imaging probes for the orexin 2 receptors. Nuclear Medicine and Biology. 40: 1000-5. PMID 23953751 DOI: 10.1016/J.Nucmedbio.2013.07.001  1
2013 Kim SW, Hooker JM, Otto N, Win K, Muench L, Shea C, Carter P, King P, Reid AE, Volkow ND, Fowler JS. Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET. Nuclear Medicine and Biology. 40: 912-8. PMID 23906667 DOI: 10.1016/J.Nucmedbio.2013.06.007  1
2013 Schroeder FA, Chonde DB, Riley MM, Moseley CK, Granda ML, Wilson CM, Wagner FF, Zhang YL, Gale J, Holson EB, Haggarty SJ, Hooker JM. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neuroscience Letters. 550: 119-24. PMID 23810801 DOI: 10.1016/J.Neulet.2013.06.016  1
2013 Wang Y, Zhang YL, Hennig K, Gale JP, Hong Y, Cha A, Riley M, Wagner F, Haggarty SJ, Holson E, Hooker J. Class I HDAC imaging using [ (3)H]CI-994 autoradiography. Epigenetics : Official Journal of the Dna Methylation Society. 8: 756-64. PMID 23803584 DOI: 10.4161/Epi.25202  1
2013 Sander CY, Hooker JM, Catana C, Normandin MD, Alpert NM, Knudsen GM, Vanduffel W, Rosen BR, Mandeville JB. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Proceedings of the National Academy of Sciences of the United States of America. 110: 11169-74. PMID 23723346 DOI: 10.1073/Pnas.1220512110  1
2013 Rotstein BH, Liang SH, Holland JP, Collier TL, Hooker JM, Wilson AA, Vasdev N. 11CO2 fixation: a renaissance in PET radiochemistry. Chemical Communications (Cambridge, England). 49: 5621-9. PMID 23673726 DOI: 10.1039/C3Cc42236D  1
2013 Wang C, Moseley CK, Carlin SM, Wilson CM, Neelamegam R, Hooker JM. Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 23: 3389-92. PMID 23601709 DOI: 10.1016/J.Bmcl.2013.03.079  1
2013 Kamlet AS, Neumann CN, Lee E, Carlin SM, Moseley CK, Stephenson N, Hooker JM, Ritter T. Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation. Plos One. 8: e59187. PMID 23554994 DOI: 10.1371/Journal.Pone.0059187  1
2013 Mandeville JB, Sander CY, Jenkins BG, Hooker JM, Catana C, Vanduffel W, Alpert NM, Rosen BR, Normandin MD. A receptor-based model for dopamine-induced fMRI signal. Neuroimage. 75: 46-57. PMID 23466936 DOI: 10.1016/J.Neuroimage.2013.02.036  1
2013 Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Molecular Psychiatry. 18: 404-16. PMID 23439487 DOI: 10.1038/Mp.2013.8  1
2013 Granda ML, Carlin SM, Moseley CK, Neelamegam R, Mandeville JB, Hooker JM. Synthesis and evaluation of methylated arylazepine compounds for PET imaging of 5-HT(2c) receptors. Acs Chemical Neuroscience. 4: 261-5. PMID 23421677 DOI: 10.1021/Cn300223D  1
2013 Diyabalanage HV, Granda ML, Hooker JM. Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer. Cancer Letters. 329: 1-8. PMID 23032720 DOI: 10.1016/J.Canlet.2012.09.018  1
2013 Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang Y, Hennig KM, Gale J, Zhao W, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, et al. Chromatin immunoprecipitation (ChIP) of nucleus accumbens from Cpd-60 treated mice. Plos One. DOI: 10.1371/Journal.Pone.0071323.G005  1
2013 Weinstein EA, Liu L, Ordonez AA, Wang H, Hooker JM, Tonge PJ, Jain SK. Noninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice Antimicrobial Agents and Chemotherapy. 57: 678. DOI: 10.1128/AAC.02274-12  1
2013 Moseley CK, Carlin SM, Neelamegam R, Hooker JM. Erratum: An efficient and practical radiosynthesis of [11C] temozolomide (Organic Letters (2012) 14 (S5)) Organic Letters. 15. DOI: 10.1021/Ol400195D  1
2013 Hansen HD, Mandeville J, Feng L, Sander CY, Hooker JM, Catana C, Rosen B, Knudsen GM. P.1.i.024 Simultaneous PET-MR imaging of the effects of microdose challenges using [11C]AZ-10419369 in non-human primates European Neuropsychopharmacology. 23. DOI: 10.1016/S0924-977X(13)70432-2  1
2012 Moseley CK, Carlin SM, Neelamegam R, Hooker JM. An efficient and practical radiosynthesis of [11C]temozolomide. Organic Letters. 14: 5872-5. PMID 23151019 DOI: 10.1021/Ol302791X  1
2012 Lee E, Hooker JM, Ritter T. Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride. Journal of the American Chemical Society. 134: 17456-8. PMID 23061667 DOI: 10.1021/Ja3084797  1
2012 Weinstein EA, Liu L, Ordonez AA, Wang H, Hooker JM, Tonge PJ, Jain SK. Noninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice. Antimicrobial Agents and Chemotherapy. 56: 6284-90. PMID 23006755 DOI: 10.1128/Aac.01644-12  1
2012 Neelamegam R, Ricq EL, Malvaez M, Patnaik D, Norton S, Carlin SM, Hill IT, Wood MA, Haggarty SJ, Hooker JM. Brain-penetrant LSD1 inhibitors can block memory consolidation. Acs Chemical Neuroscience. 3: 120-128. PMID 22754608 DOI: 10.1021/Cn200104Y  1
2012 Riss PJ, Hooker JM, Shea C, Xu Y, Carter P, Warner D, Ferrari V, Kim SW, Aigbirhio FI, Fowler JS, Roesch F. Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 22: 679-82. PMID 22082561 DOI: 10.1016/J.Bmcl.2011.10.053  1
2012 Ran C, Zhang Z, Hooker J, Moore A. In vivo photoactivation without "light": use of Cherenkov radiation to overcome the penetration limit of light. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 14: 156-62. PMID 21538154 DOI: 10.1007/S11307-011-0489-Z  1
2011 Lee E, Kamlet AS, Powers DC, Neumann CN, Boursalian GB, Furuya T, Choi DC, Hooker JM, Ritter T. A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging. Science (New York, N.Y.). 334: 639-42. PMID 22053044 DOI: 10.1126/Science.1212625  1
2011 Behrens CR, Hooker JM, Obermeyer AC, Romanini DW, Katz EM, Francis MB. Rapid chemoselective bioconjugation through oxidative coupling of anilines and aminophenols. Journal of the American Chemical Society. 133: 16398-401. PMID 21919497 DOI: 10.1021/Ja2033298  1
2011 Reid AE, Kim SW, Seiner B, Fowler FW, Hooker J, Ferrieri R, Babst B, Fowler JS. Radiosynthesis of C-11 labeled auxin (3-indolyl[1- 11C]acetic acid) and its derivatives from gramine Journal of Labelled Compounds and Radiopharmaceuticals. 54: 433-437. DOI: 10.1002/Jlcr.1894  1
2010 Hooker JM, Kim SW, Alexoff D, Xu Y, Shea C, Reid A, Volkow N, Fowler JS. Histone deacetylase inhibitor, MS-275, exhibits poor brain penetration: PK studies of [C]MS-275 using Positron Emission Tomography. Acs Chemical Neuroscience. 1: 65-73. PMID 20657706 DOI: 10.1021/Cn9000268  1
2010 Hooker JM, Kim SW, Reibel AT, Alexoff D, Xu Y, Shea C. Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates. Bioorganic & Medicinal Chemistry. 18: 7739-45. PMID 20451398 DOI: 10.1016/J.Bmc.2010.04.039  1
2010 Schönberger M, Leggett C, Kim SW, Hooker JM. Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography. Bioorganic & Medicinal Chemistry Letters. 20: 3103-6. PMID 20400305 DOI: 10.1016/J.Bmcl.2010.03.108  1
2010 Liu L, Xu Y, Shea C, Fowler JS, Hooker JM, Tonge PJ. Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons. Journal of Medicinal Chemistry. 53: 2882-91. PMID 20205479 DOI: 10.1021/Jm901858N  1
2010 Biegon A, Kim SW, Logan J, Hooker JM, Muench L, Fowler JS. Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons. Biological Psychiatry. 67: 774-7. PMID 20188349 DOI: 10.1016/J.Biopsych.2010.01.004  1
2010 Hooker JM. Modular strategies for PET imaging agents. Current Opinion in Chemical Biology. 14: 105-11. PMID 19880343 DOI: 10.1016/J.Cbpa.2009.10.005  1
2009 Hooker JM, Munro TA, Béguin C, Alexoff D, Shea C, Xu Y, Cohen BM. Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence. Neuropharmacology. 57: 386-91. PMID 19591852 DOI: 10.1016/J.Neuropharm.2009.06.044  1
2009 Riss PJ, Hooker JM, Alexoff D, Kim SW, Fowler JS, Rösch F. [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies. Bioorganic & Medicinal Chemistry Letters. 19: 4343-5. PMID 19525112 DOI: 10.1016/J.Bmcl.2009.05.090  1
2009 Schiffer WK, Liebling CN, Reiszel C, Hooker JM, Brodie JD, Dewey SL. Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6176-85. PMID 19439595 DOI: 10.1523/Jneurosci.5221-08.2009  1
2009 Hooker JM, Reibel AT, Hill SM, Schueller MJ, Fowler JS. One-pot, direct incorporation of [11C]CO2 into carbamates. Angewandte Chemie (International Ed. in English). 48: 3482-5. PMID 19350593 DOI: 10.1002/Anie.200900112  1
2009 Kim SW, Biegon A, Katsamanis ZE, Ehrlich CW, Hooker JM, Shea C, Muench L, Xu Y, King P, Carter P, Alexoff DL, Fowler JS. Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase. Nuclear Medicine and Biology. 36: 323-34. PMID 19324278 DOI: 10.1016/J.Nucmedbio.2008.12.013  1
2009 Reid AE, Hooker J, Shumay E, Logan J, Shea C, Kim SW, Collins S, Xu Y, Volkow N, Fowler JS. Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain. Nuclear Medicine and Biology. 36: 247-58. PMID 19324270 DOI: 10.1016/J.Nucmedbio.2008.12.005  1
2009 Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, Wang GJ, Jayne M, Hooker JM, Wong C, Hubbard B, Carter P, Warner D, King P, Shea C, et al. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. Jama. 301: 1148-54. PMID 19293415 DOI: 10.1001/Jama.2009.351  1
2009 Hooker JM, Patel V, Kothari S, Schiffer WK. Metabolic changes in the rodent brain after acute administration of salvinorin A. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 11: 137-43. PMID 19132449 DOI: 10.1007/S11307-008-0192-X  1
2008 Hooker JM, Schönberger M, Schieferstein H, Fowler JS. A simple, rapid method for the preparation of [11C]formaldehyde. Angewandte Chemie (International Ed. in English). 47: 5989-92. PMID 18604787 DOI: 10.1002/Anie.200800991  1
2008 Hooker JM, O'Neil JP, Romanini DW, Taylor SE, Francis MB. Genome-free viral capsids as carriers for positron emission tomography radiolabels. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 10: 182-91. PMID 18437498 DOI: 10.1007/S11307-008-0136-5  1
2008 Hooker JM, Xu Y, Schiffer W, Shea C, Carter P, Fowler JS. Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans. Neuroimage. 41: 1044-50. PMID 18434204 DOI: 10.1016/J.Neuroimage.2008.03.003  1
2008 Datta A, Hooker JM, Botta M, Francis MB, Aime S, Raymond KN. High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: nanosized MRI contrast agents. Journal of the American Chemical Society. 130: 2546-52. PMID 18247608 DOI: 10.1021/Ja0765363  1
2008 Li Z, Schram T, Witters T, Cho HJ, O'Sullivan B, Yamada N, Takaaki T, Hooker J, De Gendt S, De Meyer K. Investigation on molybdenum and its conductive oxides as p-type metal gate candidates Journal of the Electrochemical Society. 155: H481-H484. DOI: 10.1149/1.2908818  1
2007 Hooker JM, Datta A, Botta M, Raymond KN, Francis MB. Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Nano Letters. 7: 2207-10. PMID 17630809 DOI: 10.1021/Nl070512C  1
2007 Kovacs EW, Hooker JM, Romanini DW, Holder PG, Berry KE, Francis MB. Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system. Bioconjugate Chemistry. 18: 1140-7. PMID 17602681 DOI: 10.1021/Bc070006E  1
2007 Johnson HR, Hooker JM, Francis MB, Clark DS. Solubilization and stabilization of bacteriophage MS2 in organic solvents Biotechnology and Bioengineering. 97: 224-234. PMID 17099911 DOI: 10.1002/Bit.21245  1
2006 Hooker JM, Esser-Kahn AP, Francis MB. Modification of aniline containing proteins using an oxidative coupling strategy. Journal of the American Chemical Society. 128: 15558-9. PMID 17147343 DOI: 10.1021/Ja064088D  1
2004 Hooker JM, Kovacs EW, Francis MB. Interior Surface Modification of Bacteriophage MS2 Journal of the American Chemical Society. 126: 3718-3719. PMID 15038717 DOI: 10.1021/Ja031790Q  1
2003 Hooker J, Hinks D, Freeman H. Synthesis, properties and application of four new 1:2 aluminium-complexed azo dyes Coloration Technology. 119: 41-47. DOI: 10.1111/J.1478-4408.2003.Tb00150.X  1
2003 Montero G, Hinks D, Hooker J. Reducing problems of cyclic trimer deposits in supercritical carbon dioxide polyester dyeing machinery Journal of Supercritical Fluids. 26: 47-54. DOI: 10.1016/S0896-8446(02)00187-0  1
2003 Hooker J, Hinks D, Montero G, Icherenska M. Enzyme-catalyzed hydrolysis of poly(ethylene terephthalate) cyclic trimer Journal of Applied Polymer Science. 89: 2545-2552. DOI: 10.1002/App.11963  1
2002 Hooker J, Hinks D, Montero G, Conlee C. Synthesis of N,N‐diethyl‐N‐{4‐[(E)‐(4‐nitrophenyl)diazenyl]phenyl}amine via in situ diazotisation and coupling in supercritical carbon dioxide Coloration Technology. 118: 273-276. DOI: 10.1111/J.1478-4408.2002.Tb00110.X  1
2002 Hooker J, Hinks D, Montero G, Conlee C. Synthesis of N,N-diethyl-N-4-[(E)-(4-nitrophenyl)diazenyl]phenyl amine via in situ diazotisation and coupling in supercritical carbon dioxide Coloration Technology. 118: 273-276.  1
1985 Hooker JM. Widow dido Notes and Queries. 32: 56-58. DOI: 10.1093/nq/32.1.56-b  1
1981 Hooker JM. A laboratory study of the toxicity of some diphtheria-tetanus-pertussis vaccines Journal of Biological Standardization. 9: 493-506. PMID 6172427 DOI: 10.1016/S0092-1157(81)80042-X  1
1980 Hooker JM, Smith GR, Milligan RA. Immune response of mice, rabbits and cattle to inactivated Mycoplasma mycoides subspecies mycoides vaccines containing adjuvants Journal of Comparative Pathology. 90: 363-372. PMID 7026620 DOI: 10.1016/0021-9975(80)90004-3  1
1980 Hooker JM, Smith GR, Milligan RA. Immunogenic stability of heat-killed Mycoplasma mycoides subsp. Mycoides at 4 degrees C. British Veterinary Journal. 136: 614-616. PMID 7016253 DOI: 10.1016/S0007-1935(17)32144-9  1
1980 Smith GR, Hooker JM, Milligan RA. Further studies on caprine and ovine mycoplasmas related to Mycoplasma mycoides subsp. mycoides Journal of Hygiene. 85: 247-256. PMID 7005327 DOI: 10.1017/S0022172400063282  1
1979 Hooker JM, Smith GR, Milligan RA. Differentiation of Mycoplasma mycoides subsp. mycoides from certain closely related caprine mycoplasmas by mycoplasmaemia and cross-protection tests in mice Journal of Hygiene. 82: 407-418. PMID 376695 DOI: 10.1017/S0022172400053936  1
1977 Hooker JM, Butler M, Burrows R. The development of complement-fixing antibody in horses after infection with Mycoplasma equirhinis Journal of Comparative Pathology. 87: 281-286. PMID 858812 DOI: 10.1016/0021-9975(77)90015-9  1
1976 Hooker JM, Butler M. Natural incidence and persistence of complement-fixing antibody to two equine mycoplasmas Journal of Comparative Pathology. 86: 87-92. PMID 1254749 DOI: 10.1016/0021-9975(76)90032-3  1
1976 Kim JC, Hooker JM, Howard PE. IVB-1 Noise Measurements in InSb CID Linear Arrays and Operation of Two-Dimensional InSb CID Arrays Ieee Transactions On Electron Devices. 23: 1257. DOI: 10.1109/T-ED.1976.18624  1
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