Jacob Matthew Hooker, Ph.D. - Publications

Affiliations: 
1998-2002 Chemistry  North Carolina State University, Raleigh, NC 
 1998-2002 Textile Chemistry North Carolina State University, Raleigh, NC 
 2002-2007 Chemistry University of California, Berkeley, Berkeley, CA 
 2007-2012 Medical Brookhaven National Laboratory, Upton, NY, United States 
 2009- Radiology Harvard Medical School, Boston, MA, United States 
 2009- Martinos Center for Biomedical Imaging Massachusetts General Hospital, Boston, MA 
Area:
positron emission tomography, radiotracer chemistry, epigenetics, neuroscience, neurotransmitters
Website:
http://hookerlab.martinos.org/

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, ... ... Hooker JM, et al. Author Correction: [C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease. Nature Communications. 13: 5833. PMID 36192402 DOI: 10.1038/s41467-022-33668-0  0.64
2022 Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, ... ... Hooker JM, et al. [C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease. Nature Communications. 13: 4171. PMID 35853847 DOI: 10.1038/s41467-022-30653-5  0.651
2022 Edlow BL, Bodien YG, Baxter T, Belanger H, Cali R, Deary K, Fischl B, Foulkes AS, Gilmore N, Greve DN, Hooker JM, Huang SY, Kelemen JN, Kimberly WT, Maffei C, et al. Long-Term Effects of Repeated Blast Exposure in United States Special Operations Forces Personnel: A Pilot Study Protocol. Journal of Neurotrauma. PMID 35620901 DOI: 10.1089/neu.2022.0030  0.639
2022 Brusaferri L, Alshelh Z, Martins D, Kim M, Weerasekera A, Housman H, Morrissey EJ, Knight PC, Castro-Blanco KA, Albrecht DS, Tseng CE, Zürcher NR, Ratai EM, Akeju O, Makary MM, ... ... Hooker JM, et al. The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic. Brain, Behavior, and Immunity. 102: 89-97. PMID 35181440 DOI: 10.1016/j.bbi.2022.02.018  0.733
2021 Tseng CJ, McDougle CJ, Hooker JM, Zürcher NR. Epigenetics of Autism Spectrum Disorder: Histone Deacetylases. Biological Psychiatry. PMID 35120709 DOI: 10.1016/j.biopsych.2021.11.021  0.619
2021 Agaronyan A, Syed R, Kim R, Hsu CH, Love SA, Hooker JM, Reid AE, Wang PC, Ishibashi N, Kang Y, Tu TW. A Baboon Brain Atlas for Magnetic Resonance Imaging and Positron Emission Tomography Image Analysis. Frontiers in Neuroanatomy. 15: 778769. PMID 35095430 DOI: 10.3389/fnana.2021.778769  0.305
2021 Guo M, Bakhoda A, Gao ZG, Ramsey JM, Li Y, O'Conor KA, Kelleher AC, Eisenberg SM, Kang Y, Yan X, Javdan C, Fowler JS, Rice KC, Hooker JM, Jacobson KA, et al. Discovery of Highly Potent Adenosine A Receptor Agonists: Targeting Positron Emission Tomography Probes. Acs Chemical Neuroscience. PMID 34469110 DOI: 10.1021/acschemneuro.1c00397  0.483
2021 Babu S, Hightower BG, Chan J, Zürcher NR, Kivisäkk P, Tseng CJ, Sanders DL, Robichaud A, Banno H, Evora A, Ashokkumar A, Pothier L, Paganoni S, Chew S, Dojillo J, ... ... Hooker JM, et al. Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial. Neuroimage. Clinical. 30: 102672. PMID 34016561 DOI: 10.1016/j.nicl.2021.102672  0.621
2021 Zürcher NR, Roberts VHJ, Schabel MC, Edlow AG, Hooker JM, Lo JO. Imaging Epigenetics of Prenatal THC. Acs Chemical Neuroscience. PMID 33852273 DOI: 10.1021/acschemneuro.1c00176  0.637
2021 Makary MM, Weerasekara A, Rodham H, Hightower BG, Tseng CJ, Chan J, Chew S, Paganoni S, Ratai EM, Zürcher NR, Hooker JM, Atassi N, Babu S. Comparison of Two Clinical Upper Motor Neuron Burden Rating Scales in ALS Using Quantitative Brain Imaging. Acs Chemical Neuroscience. PMID 33576234 DOI: 10.1021/acschemneuro.0c00772  0.647
2021 Zürcher NR, Walsh EC, Phillips RD, Cernasov PM, Tseng CJ, Dharanikota A, Smith E, Li Z, Kinard JL, Bizzell JC, Greene RK, Dillon D, Pizzagalli DA, Izquierdo-Garcia D, Truong K, ... ... Hooker JM, et al. A simultaneous [C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism. Translational Psychiatry. 11: 33. PMID 33431841 DOI: 10.1038/s41398-020-01170-0  0.633
2020 Dalton RM, Krishnan HS, Parker VS, Catanese M, Hooker JM. The coevolution of atomic resolution and whole-brain imaging for tau neurofibrillary tangles. Acs Chemical Neuroscience. PMID 32786315 DOI: 10.1021/Acschemneuro.0C00426  0.356
2020 Downer OM, Marcus REG, Zürcher NR, Hooker JM. Tracing the History of the Human Translocator Protein to Recent Neurodegenerative and Psychiatric Imaging. Acs Chemical Neuroscience. PMID 32662626 DOI: 10.1021/Acschemneuro.0C00362  0.679
2020 Tseng CJ, Gilbert TM, Catanese MC, Hightower BG, Peters AT, Parmar AJ, Kim M, Wang C, Roffman JL, Brown HE, Perlis RH, Zürcher NR, Hooker JM. In vivo human brain expression of histone deacetylases in bipolar disorder. Translational Psychiatry. 10: 224. PMID 32641695 DOI: 10.1038/S41398-020-00911-5  0.689
2020 Koole M, Van Weehaeghe D, Serdons K, Herbots M, Cawthorne C, Celen S, Schroeder FA, Hooker JM, Bormans G, de Hoon J, Kranz JE, Van Laere K, Gilbert TM. Clinical validation of the novel HDAC6 radiotracer [F]EKZ-001 in the human brain. European Journal of Nuclear Medicine and Molecular Imaging. PMID 32638097 DOI: 10.1007/S00259-020-04891-Y  0.38
2020 Parmar A, Zürcher NR, Hooker JM. Time Will Tell the Utility of Biomarkers. Acs Chemical Neuroscience. PMID 32463674 DOI: 10.1021/Acschemneuro.0C00238  0.629
2020 Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA. Extra-axial inflammatory signal in parameninges in migraine with visual aura. Annals of Neurology. PMID 32239542 DOI: 10.1002/Ana.25731  0.711
2020 Van Weehaeghe D, Babu S, De Vocht J, Zurcher NR, Chew S, Tseng CJ, Loggia M, Koole M, Rezaei A, Schramm G, Van Damme P, Hooker JM, Van Laere K, Atassi N. Moving towards multicenter therapeutic trials in ALS: feasibility of data pooling using different TSPO positron emission tomography (PET) radioligands. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 32169920 DOI: 10.2967/Jnumed.119.241059  0.672
2020 Celen S, Rokka J, Gilbert TM, Koole M, Vermeulen I, Serdons K, Schroeder FA, Wagner FF, Bleeser T, Hightower BG, Hu J, Rahal D, Beyzavi MH, Vanduffel W, Van Laere K, ... ... Hooker JM, et al. Translation of HDAC6 PET imaging using [18F]EKZ-001 - cGMP production and measurement of HDAC6 target occupancy in NHPs. Acs Chemical Neuroscience. PMID 32159328 DOI: 10.1021/Acschemneuro.0C00074  0.393
2020 Zürcher NR, Loggia ML, Mullett JE, Tseng C, Bhanot A, Richey L, Hightower BG, Wu C, Parmar AJ, Butterfield RI, Dubois JM, Chonde DB, Izquierdo-Garcia D, Wey HY, Catana C, ... ... Hooker JM, et al. [C]PBR28 MR-PET imaging reveals lower regional brain expression of translocator protein (TSPO) in young adult males with autism spectrum disorder. Molecular Psychiatry. PMID 32076115 DOI: 10.1038/S41380-020-0682-Z  0.751
2020 Donovan LL, Magnussen JH, Dyssegaard A, Lehel S, Hooker JM, Knudsen GM, Hansen HD. Imaging HDACs In Vivo: Cross-Validation of the [C]Martinostat Radioligand in the Pig Brain. Molecular Imaging and Biology. 22: 569-577. PMID 31290052 DOI: 10.1007/S11307-019-01403-9  0.404
2019 L 'Estrade ET, Shalgunov V, Edgar FG, Strebl-Bantillo MG, Xiong M, Crestey F, Neelamegam R, Dyssegaard A, Lehel S, Erlandsson M, Ohlsson T, Hooker JM, Knudsen GM, Herth MM, Hansen HD. Radiosynthesis and preclinical evaluation of [ C]Cimbi-701 - Towards the imaging of cerebral 5-HT receptors. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 31674045 DOI: 10.1002/Jlcr.3808  0.322
2019 Gilbert TM, Zürcher NR, Catanese MC, Tseng CJ, Di Biase MA, Lyall AE, Hightower BG, Parmar AJ, Bhanot A, Wu CJ, Hibert ML, Kim M, Mahmood U, Stufflebeam SM, Schroeder FA, ... ... Hooker JM, et al. Neuroepigenetic signatures of age and sex in the living human brain. Nature Communications. 10: 2945. PMID 31270332 DOI: 10.1038/S41467-019-11031-0  0.664
2019 Dios AM, Babu S, Granucci EJ, Mueller KA, Mills AN, Alshikho MJ, Zürcher NR, Cernasov P, Gilbert TM, Glass JD, Berry JD, Atassi N, Hooker JM, Sadri-Vakili G. Class I and II HDAC expression is not altered in human amyotrophic lateral sclerosis: Neuropathological and PET molecular neuroimaging evidence. Muscle & Nerve. PMID 31241177 DOI: 10.1002/Mus.26620  0.667
2019 Hooker JM, Carson RE. Human Positron Emission Tomography Neuroimaging. Annual Review of Biomedical Engineering. 21: 551-581. PMID 31167104 DOI: 10.1146/Annurev-Bioeng-062117-121056  0.396
2019 Albrecht DS, Kim M, Akeju O, Torrado-Carvajal A, Edwards RR, Zhang Y, Bergan C, Protsenko E, Kucyi A, Wasan AD, Hooker JM, Napadow V, Loggia ML. The neuroinflammatory component of negative affect in patients with chronic pain. Molecular Psychiatry. PMID 31138890 DOI: 10.1038/S41380-019-0433-1  0.315
2019 Smith CJ, Bhanot A, Norman E, Mullett JE, Bilbo SD, McDougle CJ, Zürcher NR, Hooker JM. A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. PMID 31004246 DOI: 10.1007/S10803-019-04010-3  0.676
2019 Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Loggia ML, Hadjikhani N. Imaging of neuroinflammation in migraine with aura: A [C]PBR28 PET/MRI study. Neurology. PMID 30918090 DOI: 10.1212/Wnl.0000000000007371  0.744
2018 Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, ... ... Hooker JM, et al. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. The Journal of Clinical Investigation. PMID 30530989 DOI: 10.1172/Jci123743  0.762
2018 Paganoni S, Alshikho MJ, Luppino S, Chan J, Pothier L, Schoenfeld D, Andres PL, Babu S, Zürcher NR, Loggia ML, Barry RL, Luotti S, Nardo G, Trolese MC, Pantalone S, ... ... Hooker J, et al. A Pilot Trial of RNS60 in Amyotrophic Lateral Sclerosis. Muscle & Nerve. PMID 30458059 DOI: 10.1002/Mus.26385  0.624
2018 Strebl MG, Yang J, Isaacs L, Hooker JM. Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET. Molecular Imaging. 17: 1536012118799838. PMID 30354934 DOI: 10.1177/1536012118799838  0.387
2018 Albrecht DS, Forsberg A, Sandstrom A, Bergan C, Kadetoff D, Protsenko E, Lampa J, Lee YC, Höglund CO, Catana C, Cervenka S, Akeju O, Lekander M, Cohen G, Halldin C, ... ... Hooker JM, et al. Brain glial activation in fibromyalgia - a multi-site positron emission tomography investigation. Brain, Behavior, and Immunity. PMID 30223011 DOI: 10.1016/J.Bbi.2018.09.018  0.358
2018 Placzek MS, Schroeder FA, Che T, Wey HY, Neelamegam R, Wang C, Roth BL, Hooker JM. Discrepancies in kappa opioid agonist binding revealed through PET imaging. Acs Chemical Neuroscience. PMID 30212182 DOI: 10.1021/Acschemneuro.8B00293  0.346
2018 Ratai EM, Alshikho MJ, Zürcher NR, Loggia ML, Cebulla CL, Cernasov P, Reynolds B, Fish J, Seth R, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated imaging of [C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy H-MRS in amyotrophic lateral sclerosis. Neuroimage. Clinical. 20: 357-364. PMID 30112276 DOI: 10.1016/J.Nicl.2018.08.007  0.667
2018 Larimer BM, Dubois F, Bloch E, Nesti S, Placzek M, Zadra G, Hooker JM, Loda M, Mahmood U. Specific F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models is Facilitated by Pre-Binding to Sex Hormone Binding Globulin. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 29853654 DOI: 10.2967/Jnumed.118.208785  0.32
2018 Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Reynolds B, Pijanowski O, Chonde DB, Izquierdo Garcia D, Mainero C, Catana C, Chan J, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated MRI and [ C]-PBR28 PET Imaging in Amyotrophic Lateral sclerosis. Annals of Neurology. PMID 29740862 DOI: 10.1002/Ana.25251  0.691
2018 Lois C, Gonzalez I, Izquierdo-Garcia D, Zurcher NR, Wilkens P, Loggia ML, Hooker JM, Rosas HD. Neuroinflammation in Huntington's disease: new insights with C-PBR28 PET/MRI. Acs Chemical Neuroscience. PMID 29719953 DOI: 10.1021/Acschemneuro.8B00072  0.69
2018 Weiwer M, Xu Q, Gale JP, Lewis M, Campbell AJ, Schroeder FA, Van de Bittner GC, Walk M, Amaya A, Su P, Đorđević L, Sacher JR, Skepner A, Fei D, Dennehy K, ... ... Hooker JM, et al. Functionally biased D2R antagonists: Targeting the β-arrestin pathway to improve antipsychotic treatment. Acs Chemical Biology. PMID 29485852 DOI: 10.1021/Acschembio.8B00168  0.76
2018 Krishnan HS, Bernard-Gauthier V, Placzek MS, Dahl K, Narayanaswami V, Livni E, Chen Z, Yang J, Collier TL, Ran C, Hooker JM, Liang SH, Vasdev N. A metal protein-attenuating compound for PET neuroimaging: Synthesis and preclinical evaluation of [11C]PBT2. Molecular Pharmaceutics. PMID 29298483 DOI: 10.1021/Acs.Molpharmaceut.7B00936  0.385
2018 Paganoni S, Alshikho MJ, Zürcher NR, Cernasov P, Babu S, Loggia ML, Chan J, Chonde DB, Garcia DI, Catana C, Mainero C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Imaging of glia activation in people with primary lateral sclerosis. Neuroimage. Clinical. 17: 347-353. PMID 29159046 DOI: 10.1016/J.Nicl.2017.10.024  0.651
2017 Schoenberger M, Schroeder FA, Placzek MS, Carter RL, Rosen BR, Hooker JM, Sander CY. In vivo [(18)F]GE-179 brain signal does not show NMDA-specific modulation with drug challenges in rodents and non-human primates. Acs Chemical Neuroscience. PMID 29050469 DOI: 10.1021/Acschemneuro.7B00327  0.37
2017 Van de Bittner GC, Van de Bittner KC, Wey HY, Rowe W, Dharanipragada R, Ying X, Hurst W, Giovanni A, Alving K, Gupta A, Hoekman J, Hooker JM. Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A. Acs Chemical Neuroscience. PMID 29035509 DOI: 10.1021/Acschemneuro.7B00357  0.787
2017 Strebl MG, Campbell AJ, Zhao WN, Schroeder FA, Riley MM, Chindavong PS, Morin TM, Haggarty SJ, Wagner FF, Ritter T, Hooker JM. HDAC6 Brain Mapping with [(18)F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination. Acs Central Science. 3: 1006-1014. PMID 28979942 DOI: 10.1021/Acscentsci.7B00274  0.792
2017 Beyzavi MH, Mandal D, Strebl MG, Neumann CN, D'Amato EM, Chen J, Hooker JM, Ritter T. (18)F-Deoxyfluorination of Phenols via Ru π-Complexes. Acs Central Science. 3: 944-948. PMID 28979935 DOI: 10.1021/Acscentsci.7B00195  0.324
2017 Hansen HD, Mandeville JB, Sander CY, Hooker JM, Catana C, Rosen BR, Knudsen GM. Functional characterization of 5-HT1B receptor drugs in non-human primates using simultaneous PET-MR. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28972127 DOI: 10.1523/Jneurosci.1971-17.2017  0.354
2017 Albrecht DS, Normandin MD, Shcherbinin S, Wooten DW, Schwarz AJ, Zurcher NR, Barth VN, Guehl NJ, Johnson-Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker JM, Loggia ML. Pseudo-reference regions for glial imaging with (11)C-PBR28: investigation in two clinical cohorts. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28818984 DOI: 10.2967/Jnumed.116.178335  0.685
2017 Sander CY, Mandeville JB, Wey HY, Catana C, Hooker JM, Rosen BR. Effects of flow changes on radiotracer binding: Simultaneous measurement of neuroreceptor binding and cerebral blood flow modulation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17725418. PMID 28816571 DOI: 10.1177/0271678X17725418  0.312
2017 Kanthan M, Cumming P, Hooker JM, Vasdev N. Classics in Neuroimaging: Imaging the Dopaminergic Pathway with PET. Acs Chemical Neuroscience. PMID 28719177 DOI: 10.1021/Acschemneuro.7B00252  0.387
2017 Hu K, Patnaik D, Collier TL, Lee KN, Gao H, Swoyer MR, Rotstein BH, Krishnan HS, Liang SH, Wang J, Yan Z, Hooker JM, Vasdev N, Haggarty SJ, Ngai MY. Development of [(18)F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging. Acs Medicinal Chemistry Letters. 8: 287-292. PMID 28337318 DOI: 10.1021/Acsmedchemlett.6B00405  0.36
2017 Hooker JM, Strebl MG, Schroeder FA, Wey HY, Ambardekar AV, McKinsey TA, Schoenberger M. Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine. Scientific Reports. 7: 42136. PMID 28205593 DOI: 10.1038/Srep42136  0.331
2017 Fuin N, Pedemonte S, Catalano OA, Izquierdo-Garcia D, Soricelli A, Salvatore M, Heberlein K, Hooker JM, Van Leemput K, Catana C. PET/MR Imaging in the Presence of Metal Implants: Completion of the Attenuation Map from PET Emission Data. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28126884 DOI: 10.2967/Jnumed.116.183343  0.303
2017 Van de Bittner GC, Riley MM, Cao L, Ehses J, Herrick SP, Ricq EL, Wey HY, O'Neill MJ, Ahmed Z, Murray TK, Smith JE, Wang C, Schroeder FA, Albers MW, Hooker JM. Nasal neuron PET imaging quantifies neuron generation and degeneration. The Journal of Clinical Investigation. PMID 28112682 DOI: 10.1172/Jci89162  0.764
2017 Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, ... ... Hooker J, et al. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nature Communications. 8: 14064. PMID 28091604 DOI: 10.1038/Ncomms14064  0.334
2016 Campbell MG, Mercier J, Genicot C, Gouverneur V, Hooker JM, Ritter T. Bridging the gaps in (18)F PET tracer development. Nature Chemistry. 9: 1-3. PMID 27995923 DOI: 10.1038/Nchem.2693  0.329
2016 Schroeder FA, Gilbert TM, Feng N, Taillon BD, Volkow ND, Innis RB, Hooker JM, Lipska BK. Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia. Acs Chemical Neuroscience. PMID 27959513 DOI: 10.1021/Acschemneuro.6B00372  0.312
2016 Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Chonde DB, Izquierdo Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis. Neurology. PMID 27837005 DOI: 10.1212/Wnl.0000000000003427  0.639
2016 Wang C, Schroeder FA, Hooker JM. Development of New Positron Emission Tomography Radiotracer for BET Imaging. Acs Chemical Neuroscience. PMID 27806195 DOI: 10.1021/Acschemneuro.6B00288  0.41
2016 Herranz E, Giannì C, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Loggia ML, Sloane JA, Madigan N, Izquierdo-Garcia D, Ward N, Mangeat G, Granberg T, Klawiter EC, Catana C, ... Hooker JM, et al. The neuroinflammatory component of gray matter pathology in multiple sclerosis. Annals of Neurology. PMID 27686563 DOI: 10.1002/Ana.24791  0.311
2016 Rotstein BH, Placzek MS, Krishnan HS, Pekošak A, Collier TL, Wang C, Liang SH, Burstein ES, Hooker JM, Vasdev N. Preclinical PET Neuroimaging of [11C]Bexarotene. Molecular Imaging. 15. PMID 27553293 DOI: 10.1177/1536012116663054  0.409
2016 Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Insights into neuroepigenetics through human histone deacetylase PET imaging. Science Translational Medicine. 8: 351ra106. PMID 27510902 DOI: 10.1126/Scitranslmed.Aaf7551  0.696
2016 Ricq EL, Hooker JM, Haggarty SJ. Toward Development of Epigenetic Drugs for CNS Disorders: Modulating Neuroplasticity via H3K4 Methylation. Psychiatry and Clinical Neurosciences. PMID 27485392 DOI: 10.1111/Pcn.12426  0.315
2016 Neumann CN, Hooker JM, Ritter T. Concerted nucleophilic aromatic substitution with (19)F(-) and (18)F(.) Nature. PMID 27281221 DOI: 10.1038/Nature17667  0.311
2016 Rotstein BH, Liang SH, Placzek MS, Hooker JM, Gee AD, Dollé F, Wilson AA, Vasdev N. (11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals. Chemical Society Reviews. PMID 27276357 DOI: 10.1039/C6Cs00310A  0.336
2016 Hoover AJ, Lazari M, Ren H, Narayanam MK, Murphy JM, van Dam RM, Hooker JM, Ritter T. A Transmetalation Reaction Enables the Synthesis of [(18)F]5-Fluorouracil from [(18)F]Fluoride for Human PET Imaging. Organometallics. 35: 1008-1014. PMID 27087736 DOI: 10.1021/Acs.Organomet.6B00059  0.324
2016 Albrecht DS, Granziera C, Hooker JM, Loggia ML. In vivo imaging of human neuroinflammation. Acs Chemical Neuroscience. PMID 26985861 DOI: 10.1021/Acschemneuro.6B00056  0.377
2016 Placzek MS, Zhao W, Wey HY, Morin TM, Hooker JM. PET Neurochemical Imaging Modes. Seminars in Nuclear Medicine. 46: 20-7. PMID 26687854 DOI: 10.1053/J.Semnuclmed.2015.09.001  0.791
2016 Bittner GCVd, Riley MM, Cao L, Ehses J, Wey H, Neelamegam R, Albers M, Hooker JM. Olfactory Sensory Neuron Monitoring In Alzheimer’S Disease: Toward Human Translation Of A Pet Imaging Agent Alzheimers & Dementia. 12: 122. DOI: 10.1016/J.Jalz.2016.06.197  0.309
2015 Wang C, Placzek MS, Van de Bittner GC, Schroeder FA, Hooker JM. A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography. Acs Chemical Neuroscience. PMID 26694017 DOI: 10.1021/Acschemneuro.5B00293  0.791
2015 Strebl MG, Wang C, Schroeder FA, Placzek MS, Wey HY, Van de Bittner GC, Neelamegam R, Hooker JM. Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. Acs Chemical Neuroscience. PMID 26675505 DOI: 10.1021/Acschemneuro.5B00297  0.792
2015 Borra RJ, Cho HS, Bowen SL, Attenberger U, Arabasz G, Catana C, Josephson L, Rosen BR, Guimaraes AR, Hooker JM. Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model. Ejnmmi Physics. 2: 6. PMID 26501808 DOI: 10.1186/S40658-015-0109-0  0.334
2015 Lee SJ, Fowler JS, Alexoff D, Schueller M, Kim D, Nauth A, Weber C, Kim SW, Hooker JM, Ma L, Qu W. An efficient and practical synthesis of [2-(11)C]indole via superfast nucleophilic [(11)C]cyanation and RANEY® Nickel catalyzed reductive cyclization. Organic & Biomolecular Chemistry. PMID 26411301 DOI: 10.1039/C5Ob01654A  0.468
2015 Sander CY, Hooker JM, Catana C, Rosen BR, Mandeville JB. Imaging Agonist-Induced D2/D3 Receptor Desensitization and Internalization In Vivo with PET/fMRI. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26388148 DOI: 10.1038/Npp.2015.296  0.322
2015 Wang H, Liu L, Lu Y, Pan P, Hooker JM, Fowler JS, Tonge PJ. Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. PMID 26227776 DOI: 10.1016/J.Bmcl.2015.07.019  0.455
2015 Placzek MS, Van de Bittner GC, Wey HY, Lukas SE, Hooker JM. Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26058662 DOI: 10.1038/npp.2015.159  0.763
2015 Liang SH, Holland JP, Stephenson NA, Kassenbrock A, Rotstein BH, Daignault CP, Lewis R, Collier L, Hooker JM, Vasdev N. PET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primates. Acs Chemical Neuroscience. 6: 535-41. PMID 25776827 DOI: 10.1021/Acschemneuro.5B00055  0.341
2015 Wey HY, Wang C, Schroeder FA, Logan J, Price JC, Hooker JM. Kinetic Analysis and Quantification of [¹¹C]Martinostat for in Vivo HDAC Imaging of the Brain. Acs Chemical Neuroscience. 6: 708-15. PMID 25768025 DOI: 10.1021/Acschemneuro.5B00066  0.347
2015 Huang X, Liu W, Hooker JM, Groves JT. Targeted fluorination with the fluoride ion by manganese-catalyzed decarboxylation. Angewandte Chemie (International Ed. in English). 54: 5241-5. PMID 25736895 DOI: 10.1002/Anie.201500399  0.307
2015 Zürcher NR, Loggia ML, Lawson R, Chonde DB, Izquierdo-Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28. Neuroimage. Clinical. 7: 409-14. PMID 25685708 DOI: 10.1016/J.Nicl.2015.01.009  0.673
2015 Zürcher NR, Bhanot A, McDougle CJ, Hooker JM. A systematic review of molecular imaging (PET and SPECT) in autism spectrum disorder: current state and future research opportunities. Neuroscience and Biobehavioral Reviews. 52: 56-73. PMID 25684726 DOI: 10.1016/J.Neubiorev.2015.02.002  0.685
2015 Loggia ML, Chonde DB, Akeju O, Arabasz G, Catana C, Edwards RR, Hill E, Hsu S, Izquierdo-Garcia D, Ji RR, Riley M, Wasan AD, Zürcher NR, Albrecht DS, Vangel MG, ... ... Hooker JM, et al. Evidence for brain glial activation in chronic pain patients. Brain : a Journal of Neurology. 138: 604-15. PMID 25582579 DOI: 10.1093/Brain/Awu377  0.66
2015 McDougle CJ, Landino SM, Vahabzadeh A, O'Rourke J, Zurcher NR, Finger BC, Palumbo ML, Helt J, Mullett JE, Hooker JM, Carlezon WA. Toward an immune-mediated subtype of autism spectrum disorder. Brain Research. 1617: 72-92. PMID 25445995 DOI: 10.1016/J.Brainres.2014.09.048  0.632
2015 Gerstner E, Izquierdo D, Ou Y, Emblem K, Cai X, Da X, Chonde D, Martin N, Hooker J, Catana C, Kalpathy-Cramer J, Rosen B, Batchelor T. NIMG-29RADIOLABELED TEMOZOLOMIDE CAN MEASURE BEVACIZUMAB INDUCED VASCULAR MODULATION IN PATIENTS WITH RECURRENT GBM Neuro-Oncology. 17: v160.1-v160. DOI: 10.1093/Neuonc/Nov225.29  0.323
2014 Van de Bittner GC, Ricq EL, Hooker JM. A philosophy for CNS radiotracer design. Accounts of Chemical Research. 47: 3127-34. PMID 25272291 DOI: 10.1021/Ar500233S  0.8
2014 Wang H, Lu Y, Liu L, Kim SW, Hooker JM, Fowler JS, Tonge PJ. Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus. European Journal of Medicinal Chemistry. 88: 66-73. PMID 25217335 DOI: 10.1016/J.Ejmech.2014.09.008  0.455
2014 Wang C, Schroeder FA, Wey HY, Borra R, Wagner FF, Reis S, Kim SW, Holson EB, Haggarty SJ, Hooker JM. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. Journal of Medicinal Chemistry. 57: 7999-8009. PMID 25203558 DOI: 10.1021/Jm500872P  0.372
2014 Schroeder FA, Wang C, Van de Bittner GC, Neelamegam R, Takakura WR, Karunakaran A, Wey HY, Reis SA, Gale J, Zhang YL, Holson EB, Haggarty SJ, Hooker JM. PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. Acs Chemical Neuroscience. 5: 1055-62. PMID 25188794 DOI: 10.1021/Cn500162J  0.783
2014 Wey HY, Catana C, Hooker JM, Dougherty DD, Knudsen GM, Wang DJ, Chonde DB, Rosen BR, Gollub RL, Kong J. Simultaneous fMRI-PET of the opioidergic pain system in human brain. Neuroimage. 102: 275-82. PMID 25107855 DOI: 10.1016/J.Neuroimage.2014.07.058  0.368
2014 Diyabalanage HV, Van de Bittner GC, Ricq EL, Hooker JM. A chemical strategy for the cell-based detection of HDAC activity. Acs Chemical Biology. 9: 1257-62. PMID 25056147 DOI: 10.1021/Cb500248R  0.747
2014 Rotstein BH, Wey HY, Shoup TM, Wilson AA, Liang SH, Hooker JM, Vasdev N. PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates. Molecular Pharmaceutics. 11: 3832-8. PMID 25004399 DOI: 10.1021/Mp500316H  0.351
2014 Rotstein BH, Hooker JM, Woo J, Collier TL, Brady TJ, Liang SH, Vasdev N. Synthesis of [(11)C]Bexarotene by Cu-Mediated [(11)C]Carbon Dioxide Fixation and Preliminary PET Imaging. Acs Medicinal Chemistry Letters. 5: 668-72. PMID 24944741 DOI: 10.1021/Ml500065Q  0.349
2014 Villien M, Wey HY, Mandeville JB, Catana C, Polimeni JR, Sander CY, Zürcher NR, Chonde DB, Fowler JS, Rosen BR, Hooker JM. Dynamic functional imaging of brain glucose utilization using fPET-FDG. Neuroimage. 100: 192-9. PMID 24936683 DOI: 10.1016/J.Neuroimage.2014.06.025  0.727
2014 Ren H, Wey HY, Strebl M, Neelamegam R, Ritter T, Hooker JM. Synthesis and imaging validation of [¹⁸F]MDL100907 enabled by Ni-mediated fluorination. Acs Chemical Neuroscience. 5: 611-5. PMID 24845956 DOI: 10.1021/Cn500078E  0.37
2014 Seo YJ, Kang Y, Muench L, Reid A, Caesar S, Jean L, Wagner F, Holson E, Haggarty SJ, Weiss P, King P, Carter P, Volkow ND, Fowler JS, Hooker JM, et al. Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors. Acs Chemical Neuroscience. 5: 588-96. PMID 24780082 DOI: 10.1021/Cn500021P  0.545
2014 Huang X, Liu W, Ren H, Neelamegam R, Hooker JM, Groves JT. Late stage benzylic C-H fluorination with [¹⁸F]fluoride for PET imaging. Journal of the American Chemical Society. 136: 6842-5. PMID 24766544 DOI: 10.1021/Ja5039819  0.324
2014 Neelamegam R, Hellenbrand T, Schroeder FA, Wang C, Hooker JM. Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization. Journal of Medicinal Chemistry. 57: 1488-94. PMID 24491146 DOI: 10.1021/Jm401802F  0.396
2014 Wang C, Schroeder FA, Hooker JM. Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniques. Neuroscience. 264: 186-97. PMID 24051365 DOI: 10.1016/J.Neuroscience.2013.09.018  0.41
2013 Wang C, Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y, Neelamegam R, Schroeder FA, Holson EB, Haggarty SJ, Hooker JM. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. American Journal of Nuclear Medicine and Molecular Imaging. 4: 29-38. PMID 24380043  0.3
2013 Seo YJ, Muench L, Reid A, Chen J, Kang Y, Hooker JM, Volkow ND, Fowler JS, Kim SW. Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain. Bioorganic & Medicinal Chemistry Letters. 23: 6700-5. PMID 24210501 DOI: 10.1016/J.Bmcl.2013.10.038  0.56
2013 Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. Plos One. 8: e71323. PMID 23967191 DOI: 10.1371/Journal.Pone.0071323  0.35
2013 Wang C, Wilson CM, Moseley CK, Carlin SM, Hsu S, Arabasz G, Schroeder FA, Sander CY, Hooker JM. Evaluation of potential PET imaging probes for the orexin 2 receptors. Nuclear Medicine and Biology. 40: 1000-5. PMID 23953751 DOI: 10.1016/J.Nucmedbio.2013.07.001  0.389
2013 Kim SW, Hooker JM, Otto N, Win K, Muench L, Shea C, Carter P, King P, Reid AE, Volkow ND, Fowler JS. Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET. Nuclear Medicine and Biology. 40: 912-8. PMID 23906667 DOI: 10.1016/J.Nucmedbio.2013.06.007  0.495
2013 Schroeder FA, Chonde DB, Riley MM, Moseley CK, Granda ML, Wilson CM, Wagner FF, Zhang YL, Gale J, Holson EB, Haggarty SJ, Hooker JM. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neuroscience Letters. 550: 119-24. PMID 23810801 DOI: 10.1016/J.Neulet.2013.06.016  0.388
2013 Wang Y, Zhang YL, Hennig K, Gale JP, Hong Y, Cha A, Riley M, Wagner F, Haggarty SJ, Holson E, Hooker J. Class I HDAC imaging using [ (3)H]CI-994 autoradiography. Epigenetics : Official Journal of the Dna Methylation Society. 8: 756-64. PMID 23803584 DOI: 10.4161/Epi.25202  0.321
2013 Sander CY, Hooker JM, Catana C, Normandin MD, Alpert NM, Knudsen GM, Vanduffel W, Rosen BR, Mandeville JB. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Proceedings of the National Academy of Sciences of the United States of America. 110: 11169-74. PMID 23723346 DOI: 10.1073/Pnas.1220512110  0.315
2013 Wang C, Moseley CK, Carlin SM, Wilson CM, Neelamegam R, Hooker JM. Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 23: 3389-92. PMID 23601709 DOI: 10.1016/J.Bmcl.2013.03.079  0.372
2013 Kamlet AS, Neumann CN, Lee E, Carlin SM, Moseley CK, Stephenson N, Hooker JM, Ritter T. Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation. Plos One. 8: e59187. PMID 23554994 DOI: 10.1371/Journal.Pone.0059187  0.377
2013 Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Molecular Psychiatry. 18: 404-16. PMID 23439487 DOI: 10.1038/Mp.2013.8  0.32
2013 Granda ML, Carlin SM, Moseley CK, Neelamegam R, Mandeville JB, Hooker JM. Synthesis and evaluation of methylated arylazepine compounds for PET imaging of 5-HT(2c) receptors. Acs Chemical Neuroscience. 4: 261-5. PMID 23421677 DOI: 10.1021/Cn300223D  0.318
2013 Hansen HD, Mandeville J, Feng L, Sander CY, Hooker JM, Catana C, Rosen B, Knudsen GM. P.1.i.024 Simultaneous PET-MR imaging of the effects of microdose challenges using [11C]AZ-10419369 in non-human primates European Neuropsychopharmacology. 23. DOI: 10.1016/S0924-977X(13)70432-2  0.349
2012 Moseley CK, Carlin SM, Neelamegam R, Hooker JM. An efficient and practical radiosynthesis of [11C]temozolomide. Organic Letters. 14: 5872-5. PMID 23151019 DOI: 10.1021/Ol302791X  0.312
2012 Weinstein EA, Liu L, Ordonez AA, Wang H, Hooker JM, Tonge PJ, Jain SK. Noninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice. Antimicrobial Agents and Chemotherapy. 56: 6284-90. PMID 23006755 DOI: 10.1128/Aac.01644-12  0.326
2012 Neelamegam R, Ricq EL, Malvaez M, Patnaik D, Norton S, Carlin SM, Hill IT, Wood MA, Haggarty SJ, Hooker JM. Brain-penetrant LSD1 inhibitors can block memory consolidation. Acs Chemical Neuroscience. 3: 120-128. PMID 22754608 DOI: 10.1021/Cn200104Y  0.324
2012 Riss PJ, Hooker JM, Shea C, Xu Y, Carter P, Warner D, Ferrari V, Kim SW, Aigbirhio FI, Fowler JS, Roesch F. Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 22: 679-82. PMID 22082561 DOI: 10.1016/J.Bmcl.2011.10.053  0.508
2011 Lee E, Kamlet AS, Powers DC, Neumann CN, Boursalian GB, Furuya T, Choi DC, Hooker JM, Ritter T. A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging. Science (New York, N.Y.). 334: 639-42. PMID 22053044 DOI: 10.1126/Science.1212625  0.346
2011 Behrens CR, Hooker JM, Obermeyer AC, Romanini DW, Katz EM, Francis MB. Rapid chemoselective bioconjugation through oxidative coupling of anilines and aminophenols. Journal of the American Chemical Society. 133: 16398-401. PMID 21919497 DOI: 10.1021/Ja2033298  0.748
2011 Reid AE, Kim SW, Seiner B, Fowler FW, Hooker J, Ferrieri R, Babst B, Fowler JS. Radiosynthesis of C-11 labeled auxin (3-indolyl[1- 11C]acetic acid) and its derivatives from gramine Journal of Labelled Compounds and Radiopharmaceuticals. 54: 433-437. DOI: 10.1002/Jlcr.1894  0.472
2010 Hooker JM, Kim SW, Alexoff D, Xu Y, Shea C, Reid A, Volkow N, Fowler JS. Histone deacetylase inhibitor, MS-275, exhibits poor brain penetration: PK studies of [C]MS-275 using Positron Emission Tomography. Acs Chemical Neuroscience. 1: 65-73. PMID 20657706 DOI: 10.1021/Cn9000268  0.535
2010 Hooker JM, Kim SW, Reibel AT, Alexoff D, Xu Y, Shea C. Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates. Bioorganic & Medicinal Chemistry. 18: 7739-45. PMID 20451398 DOI: 10.1016/J.Bmc.2010.04.039  0.385
2010 Schönberger M, Leggett C, Kim SW, Hooker JM. Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography. Bioorganic & Medicinal Chemistry Letters. 20: 3103-6. PMID 20400305 DOI: 10.1016/J.Bmcl.2010.03.108  0.302
2010 Liu L, Xu Y, Shea C, Fowler JS, Hooker JM, Tonge PJ. Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons. Journal of Medicinal Chemistry. 53: 2882-91. PMID 20205479 DOI: 10.1021/Jm901858N  0.489
2010 Biegon A, Kim SW, Logan J, Hooker JM, Muench L, Fowler JS. Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons. Biological Psychiatry. 67: 774-7. PMID 20188349 DOI: 10.1016/J.Biopsych.2010.01.004  0.478
2010 Hooker JM. Modular strategies for PET imaging agents. Current Opinion in Chemical Biology. 14: 105-11. PMID 19880343 DOI: 10.1016/J.Cbpa.2009.10.005  0.373
2010 Riss PJ, Hooker JM, Alexoff D, Kim S, Hummerich R, Ferrari VA, Schloss P, Fowler JS, Roesch F, Aigbirhio FI. Automated GMP production of [11C]PR04.MZ via the captive solvent method and PET studies in non-human primates: A promising tracer for extrastriatal DAT imaging Neuroimage. 52: S117. DOI: 10.1016/J.Neuroimage.2010.04.096  0.519
2009 Hooker JM, Munro TA, Béguin C, Alexoff D, Shea C, Xu Y, Cohen BM. Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence. Neuropharmacology. 57: 386-91. PMID 19591852 DOI: 10.1016/J.Neuropharm.2009.06.044  0.332
2009 Riss PJ, Hooker JM, Alexoff D, Kim SW, Fowler JS, Rösch F. [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies. Bioorganic & Medicinal Chemistry Letters. 19: 4343-5. PMID 19525112 DOI: 10.1016/J.Bmcl.2009.05.090  0.519
2009 Hooker JM, Reibel AT, Hill SM, Schueller MJ, Fowler JS. One-pot, direct incorporation of [11C]CO2 into carbamates. Angewandte Chemie (International Ed. in English). 48: 3482-5. PMID 19350593 DOI: 10.1002/Anie.200900112  0.493
2009 Kim SW, Biegon A, Katsamanis ZE, Ehrlich CW, Hooker JM, Shea C, Muench L, Xu Y, King P, Carter P, Alexoff DL, Fowler JS. Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase. Nuclear Medicine and Biology. 36: 323-34. PMID 19324278 DOI: 10.1016/J.Nucmedbio.2008.12.013  0.5
2009 Reid AE, Hooker J, Shumay E, Logan J, Shea C, Kim SW, Collins S, Xu Y, Volkow N, Fowler JS. Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain. Nuclear Medicine and Biology. 36: 247-58. PMID 19324270 DOI: 10.1016/J.Nucmedbio.2008.12.005  0.508
2009 Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, Wang GJ, Jayne M, Hooker JM, Wong C, Hubbard B, Carter P, Warner D, King P, Shea C, et al. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. Jama. 301: 1148-54. PMID 19293415 DOI: 10.1001/Jama.2009.351  0.448
2008 Hooker JM, Schönberger M, Schieferstein H, Fowler JS. A simple, rapid method for the preparation of [11C]formaldehyde. Angewandte Chemie (International Ed. in English). 47: 5989-92. PMID 18604787 DOI: 10.1002/Anie.200800991  0.445
2008 Hooker JM, O'Neil JP, Romanini DW, Taylor SE, Francis MB. Genome-free viral capsids as carriers for positron emission tomography radiolabels. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 10: 182-91. PMID 18437498 DOI: 10.1007/S11307-008-0136-5  0.79
2008 Hooker JM, Xu Y, Schiffer W, Shea C, Carter P, Fowler JS. Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans. Neuroimage. 41: 1044-50. PMID 18434204 DOI: 10.1016/J.Neuroimage.2008.03.003  0.522
2008 Datta A, Hooker JM, Botta M, Francis MB, Aime S, Raymond KN. High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: nanosized MRI contrast agents. Journal of the American Chemical Society. 130: 2546-52. PMID 18247608 DOI: 10.1021/Ja0765363  0.538
2008 Hooker J, Schönberger M, Schieferstein H, Fowler J. Eine einfache und schnelle Methode zur Herstellung von [11C]Formaldehyd Angewandte Chemie. 120: 6078-6081. DOI: 10.1002/Ange.200800991  0.438
2007 Hooker JM, Datta A, Botta M, Raymond KN, Francis MB. Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies. Nano Letters. 7: 2207-10. PMID 17630809 DOI: 10.1021/Nl070512C  0.555
2007 Kovacs EW, Hooker JM, Romanini DW, Holder PG, Berry KE, Francis MB. Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system. Bioconjugate Chemistry. 18: 1140-7. PMID 17602681 DOI: 10.1021/Bc070006E  0.747
2007 Johnson HR, Hooker JM, Francis MB, Clark DS. Solubilization and stabilization of bacteriophage MS2 in organic solvents Biotechnology and Bioengineering. 97: 224-234. PMID 17099911 DOI: 10.1002/Bit.21245  0.702
2006 Hooker JM, Esser-Kahn AP, Francis MB. Modification of aniline containing proteins using an oxidative coupling strategy. Journal of the American Chemical Society. 128: 15558-9. PMID 17147343 DOI: 10.1021/Ja064088D  0.71
2006 Francis MB, Antos JM, Bains S, Crochet AP, Gilmore JM, Hooker JM, Joshi NS, McFarland JM, Nguyen T, Patel AA, et al. ea. New Chemical Tools for Protein Modification Cheminform. 37. DOI: 10.1002/chin.200604251  0.713
2004 Hooker JM, Kovacs EW, Francis MB. Interior Surface Modification of Bacteriophage MS2 Journal of the American Chemical Society. 126: 3718-3719. PMID 15038717 DOI: 10.1021/Ja031790Q  0.741
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