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Kellie D. Nance - Publications

Affiliations: 
Chemistry Vanderbilt University, Nashville, TN 
Area:
Organic Synthesis, Medicinal Chemistry
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Perez M, Nance KD, Bak DW, Thalalla Gamage S, Najera SS, Conte AN, Linehan WM, Weerapana E, Meier JL. Conditional Covalent Lethality Driven by Oncometabolite Accumulation. Acs Chemical Biology. PMID 36190452 DOI: 10.1021/acschembio.2c00384  0.536
2022 Bartee D, Nance KD, Meier JL. Site-Specific Synthesis of -Acetylcytidine in RNA Reveals Physiological Duplex Stabilization. Journal of the American Chemical Society. PMID 35172571 DOI: 10.1021/jacs.1c11985  0.548
2021 Nance KD, Gamage ST, Alam MM, Yang A, Levy MJ, Link CN, Florens L, Washburn MP, Gu S, Oppenheim JJ, Meier JL. Cytidine acetylation yields a hypoinflammatory synthetic messenger RNA. Cell Chemical Biology. 29: 312-320.e7. PMID 35180432 DOI: 10.1016/j.chembiol.2021.07.003  0.537
2021 Shrimp JH, Jing Y, Gamage ST, Nelson KM, Han J, Bryson KM, Montgomery DC, Thomas JM, Nance KD, Sharma S, Fox SD, Andressen T, Sinclair WR, Wu H, Allali-Hassani A, et al. Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation. Acs Medicinal Chemistry Letters. 12: 887-892. PMID 34141066 DOI: 10.1021/acsmedchemlett.0c00193  0.709
2021 Nance KD, Meier JL. Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines. Acs Central Science. 7: 748-756. PMID 34075344 DOI: 10.1021/acscentsci.1c00197  0.478
2020 Sas-Chen A, Thomas JM, Matzov D, Taoka M, Nance KD, Nir R, Bryson KM, Shachar R, Liman GLS, Burkhart BW, Gamage ST, Nobe Y, Briney CA, Levy MJ, Fuchs RT, et al. Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature. PMID 32555463 DOI: 10.1038/S41586-020-2418-2  0.684
2020 Shrimp JH, Jing Y, Gamage ST, Nelson KM, Han J, Bryson KM, Montgomery DC, Thomas JM, Nance KD, Sharma S, Fox SD, Andressen T, Sinclair WR, Wu H, Allali-Hassani A, et al. Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation Acs Medicinal Chemistry Letters. DOI: 10.1021/Acsmedchemlett.0C00193  0.584
2019 Levy MJ, Montgomery DC, Sardiu ME, Montano JL, Bergholtz SE, Nance KD, Thorpe AL, Fox SD, Lin Q, Andresson T, Florens L, Washburn MP, Meier JL. A Systems Chemoproteomic Analysis of Acyl-CoA/Protein Interaction Networks. Cell Chemical Biology. PMID 31836350 DOI: 10.1016/J.Chembiol.2019.11.011  0.542
2019 Reed CW, Fulton MG, Nance KD, Lindsley CW. Total synthesis of natural (−)- and unnatural (+)-Melearoride A Tetrahedron Letters. 60: 743-745. DOI: 10.1016/J.Tetlet.2019.02.006  0.412
2018 Thomas JM, Briney CA, Nance KD, Lopez JE, Thorpe AL, Fox SD, Bortolin-Cavaille ML, Sas-Chen A, Arango D, Oberdoerffer S, Cavaille J, Andresson T, Meier JL. A Chemical Signature for Cytidine Acetylation in RNA. Journal of the American Chemical Society. PMID 30252461 DOI: 10.1021/Jacs.8B06636  0.72
2018 Bertron JL, Cho HP, Garcia-Barrantes PM, Panarese JD, Salovich JM, Nance KD, Engers DW, Rook JM, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW. The discovery of VU0486846: steep SAR from a series of M PAMs based on a novel benzomorpholine core. Bioorganic & Medicinal Chemistry Letters. PMID 29754948 DOI: 10.1016/J.Bmcl.2018.05.009  0.693
2018 Rook JM, Bertron JL, Cho HP, Garcia-Barrantes PM, Moran SP, Maksymetz JT, Nance KD, Dickerson JW, Remke DH, Chang S, Harp J, Blobaum AL, Niswender CM, Jones CK, Stauffer SR, et al. A novel M1 PAM VU0486846 exerts efficacy in cognition models without displaying agonist activity or cholinergic toxicity. Acs Chemical Neuroscience. PMID 29701957 DOI: 10.1021/Acschemneuro.8B00131  0.691
2018 Bender AM, Cho HP, Nance KD, Lingenfelter KS, Luscombe VB, Gentry PR, Voigtritter K, Berizzi AE, Sexton PM, Langmead C, Christopoulos A, Locuson CW, Bridges TM, Chang S, O'Neil JC, et al. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring PAMs Derived From a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold. Acs Chemical Neuroscience. PMID 29678111 DOI: 10.1021/Acschemneuro.8B00126  0.591
2017 Melancon BJ, Wood MR, Noetzel MJ, Nance KD, Engelberg EM, Han C, Lamsal A, Chang S, Cho HP, Byers FW, Bubser M, Jones CK, Niswender CM, Wood MW, Engers DW, et al. Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology. Bioorganic & Medicinal Chemistry Letters. PMID 28442253 DOI: 10.1016/J.Bmcl.2017.04.043  0.582
2017 McGowan KM, Nance KD, Cho HP, Bridges TM, Jeffrey Conn P, Jones CK, Lindsley CW. Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorganic & Medicinal Chemistry Letters. PMID 28237763 DOI: 10.1016/J.Bmcl.2017.02.020  0.535
2017 Wood MR, Noetzel MJ, Melancon BJ, Poslusney MS, Nance KD, Hurtado MA, Luscombe VB, Weiner RL, Rodriguez AL, Lamsal A, Chang S, Bubser M, Blobaum AL, Engers DW, Niswender CM, et al. Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia. Acs Medicinal Chemistry Letters. 8: 233-238. PMID 28197318 DOI: 10.1021/Acsmedchemlett.6B00461  0.571
2017 Nance KD, Days EL, Weaver CD, Coldren A, Farmer TD, Cho HP, Niswender CM, Blobaum AL, Niswender KD, Lindsley CW. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. Journal of Medicinal Chemistry. PMID 28103022 DOI: 10.1021/Acs.Jmedchem.6B01706  0.449
2016 Rook JM, Abe M, Cho HP, Nance KD, Luscombe VB, Adams JJ, Dickerson JW, Remke DH, Garcia-Barrantes PM, Engers DW, Engers JL, Chang S, Foster JJ, Blobaum AL, Niswender CM, et al. Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs. Acs Chemical Neuroscience. PMID 28001356 DOI: 10.1021/Acschemneuro.6B00429  0.781
2016 Grannan MD, Mielnik CA, Moran S, Gould RW, Ball JR, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, et al. Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction are Reversed by the Novel M1 PAM VU6004256. Acs Chemical Neuroscience. PMID 27617634 DOI: 10.1021/Acschemneuro.6B00230  0.535
2016 Geanes AR, Cho HP, Nance KD, McGowan KM, Conn PJ, Jones CK, Meiler J, Lindsley CW. Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes. Bioorganic & Medicinal Chemistry Letters. PMID 27503678 DOI: 10.1016/J.Bmcl.2016.07.071  0.586
2016 Panarese JD, Cho HP, Adams JJ, Nance KD, Garcia-Barrantes PM, Chang S, Morrison RD, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW. Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. Bioorganic & Medicinal Chemistry Letters. PMID 27173801 DOI: 10.1016/J.Bmcl.2016.04.083  0.762
2014 Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). Journal of Medicinal Chemistry. 57: 10192-7. PMID 25423411 DOI: 10.1021/Jm501375C  0.451
2014 Uddin MJ, Elleman AV, Ghebreselasie K, Daniel CK, Crews BC, Nance KD, Huda T, Marnett LJ. Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors. Acs Medicinal Chemistry Letters. 5: 1254-8. PMID 25408841 DOI: 10.1021/Ml500344J  0.356
2014 Wen W, Young SE, Duvernay MT, Schulte ML, Nance KD, Melancon BJ, Engers J, Locuson CW, Wood MR, Daniels JS, Wu W, Lindsley CW, Hamm HE, Stauffer SR. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorganic & Medicinal Chemistry Letters. 24: 4708-13. PMID 25176330 DOI: 10.1016/J.Bmcl.2014.08.021  0.665
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