Christopher J. Schofield, D.Phil. - Publications

Affiliations: 
1982- Chemistry University of Oxford, Oxford, United Kingdom 
Area:
Enzymes
Website:
http://research.chem.ox.ac.uk/christopher-schofield.aspx

401 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Parkova A, Lucic A, Krajnc A, Brem J, Calvopina K, Langley G, McDonough MA, Trapencieris P, Schofield CJ. Broad Spectrum β-lactamase Inhibition by a Thioether Substituted Bicyclic Boronate. Acs Infectious Diseases. PMID 31841636 DOI: 10.1021/acsinfecdis.9b00330  1
2019 Reinbold R, John T, Spingardi P, Kawamura A, Thompson AL, Schofield CJ, Hopkinson RJ. Formaldehyde quantification using ampicillin is not selective. Scientific Reports. 9: 18289. PMID 31797955 DOI: 10.1038/s41598-019-54610-3  1
2019 Smart TJ, Hamed RB, Claridge TDW, Schofield CJ. Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles. Bioorganic Chemistry. 103386. PMID 31706681 DOI: 10.1016/j.bioorg.2019.103386  0.96
2019 Pfeffer I, Brewitz L, Krojer T, Jensen SA, Kochan GT, Kershaw NJ, Hewitson KS, McNeill LA, Kramer H, Münzel M, Hopkinson RJ, Oppermann U, Handford PA, McDonough MA, Schofield CJ. Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nature Communications. 10: 4910. PMID 31659163 DOI: 10.1038/s41467-019-12711-7  1
2019 Lohans CT, Freeman EI, Groesen EV, Tooke CL, Hinchliffe P, Spencer J, Brem J, Schofield CJ. Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation. Scientific Reports. 9: 13608. PMID 31541180 DOI: 10.1038/s41598-019-49264-0  0.68
2019 Li G, Su Y, Yan YH, Peng JY, Dai QQ, Ning XL, Zhu CL, Fu C, McDonough MA, Schofield CJ, Huang C, Li GB. MeLAD: an integrated resource for metalloenzyme-ligand associations. Bioinformatics (Oxford, England). PMID 31504189 DOI: 10.1093/bioinformatics/btz648  1
2019 de Munnik M, Lohans CT, Lang PA, Langley GW, Malla TR, Tumber A, Schofield CJ, Brem J. Targeting the Mycobacterium tuberculosis transpeptidase Ldt with cysteine-reactive inhibitors including ebselen. Chemical Communications (Cambridge, England). PMID 31380528 DOI: 10.1039/c9cc04145a  0.68
2019 de Munnik M, Lohans CT, Langley GW, Bon C, Brem J, Schofield C. A Fluorescence-based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2. Chembiochem : a European Journal of Chemical Biology. PMID 31322798 DOI: 10.1002/cbic.201900379  0.68
2019 Admiraal SJ, Eyler DE, Baldwin MR, Brines EM, Lohans CT, Schofield CJ, O'Brien PJ. Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast. The Journal of Biological Chemistry. PMID 31320474 DOI: 10.1074/jbc.RA119.009813  0.68
2019 van Groesen E, Lohans CT, Brem J, Aertker KM, Claridge TD, Schofield C. 19F-NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31310409 DOI: 10.1002/chem.201902529  0.68
2019 Roatsch M, Hoffmann I, Abboud MI, Hancock RL, Tarhonskaya H, Hsu KF, Wilkins SE, Yeh TL, Lippl K, Serrer K, Moneke I, Ahrens TD, Robaa D, Wenzler S, Barthes NPF, ... ... Schofield CJ, et al. The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases. Acs Chemical Biology. PMID 31287655 DOI: 10.1021/acschembio.9b00289  1
2019 Hamed RB, Gomez-Castellanos JR, Henry L, Warhaut S, Claridge TDW, Schofield CJ. Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases. Communications Chemistry. 2. PMID 31157308 DOI: 10.1038/s42004-018-0106-z  0.96
2019 Islam MS, McDonough MA, Chowdhury R, Gault J, Khan A, Pires E, Schofield CJ. Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6. The Journal of Biological Chemistry. PMID 31147442 DOI: 10.1074/jbc.RA119.008693  1
2019 Holt-Martyn JP, Tumber A, Rahman MZ, Lippl K, Figg W, McDonough MA, Chowdhury R, Schofield CJ. Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors. Medchemcomm. 10: 500-504. PMID 31057728 DOI: 10.1039/c8md00548f  1
2019 Shaikh F, Zhao Y, Alvarez L, Iliopoulou M, Lohans CT, Schofield CJ, Padilla-Parra S, Siu SWI, Fry E, Ren J, Stuart DI. Structure-based In Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library. Journal of Medicinal Chemistry. PMID 30785281 DOI: 10.1021/acs.jmedchem.8b01328  0.68
2019 Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J. Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates. Biochimica Et Biophysica Acta. General Subjects. PMID 30738906 DOI: 10.1016/j.bbagen.2019.02.004  1
2019 Langley GW, Abboud MI, Lohans CT, Schofield CJ. Inhibition of a viral prolyl hydroxylase. Bioorganic & Medicinal Chemistry. PMID 30737136 DOI: 10.1016/j.bmc.2019.01.018  0.8
2018 Lohans CT, Chan HTH, Malla TR, Kumar K, Kamps JJAG, McArdle DJB, van Groesen E, de Munnik M, Tooke CL, Spencer J, Paton RS, Brem J, Schofield C. Non-Hydrolytic β-Lactam Antibiotic Fragmentation by L,D-Transpeptidases and Serine β-Lactamase Cysteine Variants. Angewandte Chemie (International Ed. in English). PMID 30569575 DOI: 10.1002/anie.201809424  0.68
2018 Lippl K, Boleininger A, McDonough MA, Abboud MI, Tarhonskaya H, Chowdhury R, Loenarz C, Schofield CJ. Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal . Hypoxia (Auckland, N.Z.). 6: 57-71. PMID 30519597 DOI: 10.2147/HP.S174655  1
2018 Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ. Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease. Elife. 7. PMID 30507380 DOI: 10.7554/eLife.39865  1
2018 Bush JT, Leśniak RK, Yeh TL, Belle R, Kramer H, Tumber A, Chowdhury R, Flashman E, Mecinović J, Schofield CJ. Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture. Chemical Communications (Cambridge, England). PMID 30452037 DOI: 10.1039/c8cc07706a  1
2018 Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J. Crystal Structures of VIM-1 Complexes Explain Active Site Heterogeneity in VIM-Class Metallo-β-Lactamases. The Febs Journal. PMID 30430727 DOI: 10.1111/febs.14695  1
2018 Thinnes CC, Lohans CT, Abboud MI, Yeh TL, Tumber A, Nowak RP, Attwood M, Cockman ME, Oppermann U, Loenarz C, Schofield C. Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30427558 DOI: 10.1002/chem.201804790  1
2018 Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh TL, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N. A Fluorescent Benzo[g]isoquinoline-based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging. Chemmedchem. PMID 30380199 DOI: 10.1002/cmdc.201800483  0.8
2018 Kulkarni A, Taylor GP, Klose RJ, Schofield CJ, Bangham CR. Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1. Jci Insight. 3. PMID 30333309 DOI: 10.1172/jci.insight.123196  0.4
2018 Wang Y, Zhong S, Schofield CJ, Ratcliffe PJ, Lu X. Nuclear entry and export of FIH are mediated by HIF1α and exportin1 respectively. Journal of Cell Science. PMID 30333145 DOI: 10.1242/jcs.219782  0.72
2018 Walport LJ, Hopkinson RJ, Chowdhury R, Zhang Y, Bonnici J, Schiller R, Kawamura A, Schofield CJ. Mechanistic and Structural Studies of KDM-Catalysed Demethylation of Histone 1 Isotype 4 at Lysine 26. Febs Letters. PMID 30156264 DOI: 10.1002/1873-3468.13231  1
2018 Walport LJ, Schofield CJ. Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis. Chemical Record (New York, N.Y.). PMID 30151867 DOI: 10.1002/tcr.201800056  0.8
2018 Abboud M, Chowdhury R, Leung I, Lippl K, Loenarz C, Claridge TDW, Schofield C. Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain. Chembiochem : a European Journal of Chemical Biology. PMID 30144273 DOI: 10.1002/cbic.201800246  1
2018 Tarhonskaya H, Tumber A, Kawamura A, Schofield CJ. In Vitro Enzyme Assays for JmjC-Domain-Containing Lysine Histone Demethylases (JmjC-KDMs). Current Protocols in Pharmacology. 80: 3.15.1-3.15.12. PMID 30040204 DOI: 10.1002/cpph.34  1
2018 Hopkinson RJ, Langley GW, Belle R, Walport LJ, Dunne K, Münzel M, Salah E, Kawamura A, Claridge TDW, Schofield CJ. Human histone demethylase KDM6B can catalyse sequential oxidations. Chemical Communications (Cambridge, England). PMID 29961803 DOI: 10.1039/c8cc04057e  1
2018 Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, ... ... Schofield CJ, et al. Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nature Chemical Biology. PMID 29950663 DOI: 10.1038/s41589-018-0104-6  1
2018 Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, ... ... Schofield CJ, et al. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nature Chemical Biology. 14: 688-695. PMID 29915238 DOI: 10.1038/s41589-018-0071-y  1
2018 Rabe P, Kamps JJAG, Schofield CJ, Lohans CT. Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis. Natural Product Reports. PMID 29808887 DOI: 10.1039/c8np00002f  0.68
2018 Bhushan B, Erdmann A, Zhang Y, Belle R, Johannson C, Oppermann U, Hopkinson RJ, Schofield CJ, Kawamura A. Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases. Bioorganic & Medicinal Chemistry. PMID 29764755 DOI: 10.1016/j.bmc.2018.03.030  1
2018 Wilkins SE, Islam MS, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R. Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase. Nature Communications. 9: 1675. PMID 29686330 DOI: 10.1038/s41467-018-04196-7  1
2018 Bonnici J, Tumber A, Kawamura A, Schofield CJ. Inhibitors of both the -methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29685975 DOI: 10.1098/rstb.2017.0071  1
2018 Zhang D, Markoulides MS, Stepanovs D, Rydzik AM, El-Hussein A, Bon C, Kamps JJAG, Umland KD, Collins PM, Cahill ST, Wang DY, von Delft F, Brem J, McDonough MA, Schofield CJ. Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases. Bioorganic & Medicinal Chemistry. PMID 29655609 DOI: 10.1016/j.bmc.2018.02.043  1
2018 Johnson TC, Elbert BL, Farley AJM, Gorman TW, Genicot C, Lallemand B, Pasau P, Flasz J, Castro JL, MacCoss M, Dixon DJ, Paton RS, Schofield CJ, Smith MD, Willis MC. Direct sulfonylation of anilines mediated by visible light. Chemical Science. 9: 629-633. PMID 29629128 DOI: 10.1039/c7sc03891g  0.48
2018 Wilkins SE, Islam S, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R. JMJD5 is a human arginyl C-3 hydroxylase. Nature Communications. 9: 1180. PMID 29563586 DOI: 10.1038/s41467-018-03410-w  1
2018 Sekirnik R, Wilkins SE, Bush J, Tarhonskaya H, Münzel M, Hussein A, Flashman E, Mohammed S, McDonough MA, Loenarz C, Schofield CJ. YcfDis a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase. Extremophiles : Life Under Extreme Conditions. PMID 29523972 DOI: 10.1007/s00792-018-1016-9  1
2018 Abboud MI, McAllister TE, Leung IKH, Chowdhury R, Jorgensen C, Domene C, Mecinović J, Lippl K, Hancock RL, Hopkinson RJ, Kawamura A, Claridge TDW, Schofield CJ. 2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2. Chemical Communications (Cambridge, England). PMID 29522057 DOI: 10.1039/c8cc00387d  1
2018 Islam MS, Leissing TM, Chowdhury R, Hopkinson RJ, Schofield CJ. 2-Oxoglutarate-Dependent Oxygenases. Annual Review of Biochemistry. PMID 29494239 DOI: 10.1146/annurev-biochem-061516-044724  1
2018 Hancock RL, Abboud MI, Smart TJ, Flashman E, Kawamura A, Schofield CJ, Hopkinson R. Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation. Chembiochem : a European Journal of Chemical Biology. PMID 29443450 DOI: 10.1002/cbic.201800002  1
2018 Hopkinson RJ, Schofield CJ. Deciphering Functions of Intracellular Formaldehyde: Linking Cancer and Aldehyde Metabolism. Biochemistry. PMID 29368521 DOI: 10.1021/acs.biochem.7b01304  0.8
2017 Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, ... ... Schofield CJ, et al. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chemical Science. 8: 7651-7668. PMID 29435217 DOI: 10.1039/c7sc02103h  1
2017 Dickinson RS, Murphy F, Doherty C, Williams S, Mirchandani A, Willson J, Scotti JS, Preston G, Schofield CJ, Whyte MKB, Walmsley SR. Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo. Wellcome Open Research. 2: 104. PMID 29387803 DOI: 10.12688/wellcomeopenres.12871.1  0.64
2017 Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh P, Schofield CJ, Fishwick CWG. In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors. Journal of Medicinal Chemistry. PMID 29271657 DOI: 10.1021/acs.jmedchem.7b01728  1
2017 Abboud MI, Kosmopoulou M, Krismanich A, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield C, Dmitrienko GI. Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29250863 DOI: 10.1002/chem.201705886  0.84
2017 Lohans CT, van Groesen E, Kumar K, Tooke CL, Spencer J, Paton RS, Brem J, Schofield C. A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems via Lactone Formation. Angewandte Chemie (International Ed. in English). PMID 29236332 DOI: 10.1002/anie.201711308  0.68
2017 Belle R, Al Temimi AHK, Kumar K, Pieters BJGE, Tumber A, Dunford JE, Johansson C, Oppermann U, Brown T, Schofield CJ, Hopkinson RJ, Paton RS, Kawamura A, Mecinović J. Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition. Chemical Communications (Cambridge, England). 53: 13264-13267. PMID 29186216 DOI: 10.1039/c7cc08028j  1
2017 Lohans CT, Brem J, Schofield CJ. New Delhi metallo-β-lactamase-1 catalyses avibactam and aztreonam hydrolysis. Antimicrobial Agents and Chemotherapy. PMID 28971873 DOI: 10.1128/AAC.01224-17  0.68
2017 Kulkarni A, Mateus M, Thinnes CC, McCullagh JS, Schofield CJ, Taylor GP, Bangham CRM. Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1. Cell Chemical Biology. PMID 28965728 DOI: 10.1016/j.chembiol.2017.08.016  0.76
2017 Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB. Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Molecular Microbiology. PMID 28876489 DOI: 10.1111/mmi.13831  0.68
2017 Tarhonskaya H, Nowak RP, Johansson C, Szykowska A, Tumber A, Hancock RL, Lang P, Flashman E, Oppermann U, Schofield CJ, Kawamura A. Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates. Journal of Molecular Biology. PMID 28827149 DOI: 10.1016/j.jmb.2017.08.007  1
2017 Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, ... ... Schofield CJ, et al. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. The Journal of Clinical Investigation. PMID 28805660 DOI: 10.1172/JCI90848  0.44
2017 McNeill L, Brown T, Sami M, Clifton I, Burzlaff N, Claridge T, Adlington R, Baldwin J, Rutledge PJ, Schofield C. Terminally truncated isopenicillin N synthase generates a dithioester product: evidence for a thioaldehyde intermediate and a new mode of reaction for non-heme iron oxidases. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28703303 DOI: 10.1002/chem.201701592  0.72
2017 Lohans CT, Wang DY, Jorgensen C, Cahill ST, Clifton IJ, McDonough MA, Oswin HP, Spencer J, Domene C, Claridge TDW, Brem J, Schofield CJ. (13)C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions. Organic & Biomolecular Chemistry. PMID 28678295 DOI: 10.1039/c7ob01514c  1
2017 Kiriakidis S, Hoer SS, Burrows N, Biddlecome G, Khan MN, Thinnes CC, Schofield CJ, Rogers N, Botto M, Paleolog E, Maxwell PH. Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor. Kidney International. PMID 28506759 DOI: 10.1016/j.kint.2017.03.008  0.76
2017 Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ. Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition. Chemical Communications (Cambridge, England). PMID 28470248 DOI: 10.1039/c7cc02394d  1
2017 Li GB, Abboud MI, Brem J, Someya H, Lohans CT, Yang SY, Spencer J, Wareham DW, McDonough MA, Schofield CJ. NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors. Chemical Science. 8: 928-937. PMID 28451231 DOI: 10.1039/c6sc04524c  1
2017 Zhang Z, Smart TJ, Choi H, Hardy F, Lohans CT, Abboud MI, Richardson MSW, Paton RS, McDonough MA, Schofield CJ. Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate. Proceedings of the National Academy of Sciences of the United States of America. PMID 28420789 DOI: 10.1073/pnas.1617760114  1
2017 Kawamura A, Münzel M, Kojima T, Yapp C, Bhushan B, Goto Y, Tumber A, Katoh T, King ON, Passioura T, Walport LJ, Hatch SB, Madden S, Müller S, Brennan PE, ... ... Schofield CJ, et al. Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. Nature Communications. 8: 14773. PMID 28382930 DOI: 10.1038/ncomms14773  1
2017 Hatch SB, Yapp C, Montenegro RC, Savitsky P, Gamble V, Tumber A, Ruda GF, Bavetsias V, Fedorov O, Atrash B, Raynaud F, Lanigan R, Carmichael L, Tomlin K, Burke R, ... ... Schofield CJ, et al. Assessing histone demethylase inhibitors in cells: lessons learned. Epigenetics & Chromatin. 10: 9. PMID 28265301 DOI: 10.1186/s13072-017-0116-6  1
2017 Tumber A, Nuzzi A, Hookway ES, Hatch SB, Velupillai S, Johansson C, Kawamura A, Savitsky P, Yapp C, Szykowska A, Wu N, Bountra C, Strain-Damerell C, Burgess-Brown NA, Ruda GF, ... ... Schofield CJ, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chemical Biology. PMID 28262558 DOI: 10.1016/j.chembiol.2017.02.006  1
2017 Abboud MI, Hinchliffe P, Brem J, Macsics R, Pfeffer I, Makena A, Umland KD, Rydzik AM, Li GB, Spencer J, Claridge TD, Schofield CJ. (19) F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase. Angewandte Chemie (International Ed. in English). PMID 28252254 DOI: 10.1002/anie.201612185  0.8
2017 Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N, van Heyningen V, Wills J, von Kriegsheim A, Finch A, Sakai J, Schofield CJ, Jackson IJ, et al. KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability. The Journal of Cell Biology. PMID 28246120 DOI: 10.1083/jcb.201607032  1
2017 Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CW, McDonough MA, Schofield CJ, Brem J. Cyclic Boronates Inhibit All Classes of β-Lactamase. Antimicrobial Agents and Chemotherapy. PMID 28115348 DOI: 10.1128/AAC.02260-16  1
2017 Hinchliffe P, Yang QE, Portal E, Young T, Li H, Tooke CL, Carvalho MJ, Paterson NG, Brem J, Niumsup PR, Tansawai U, Lei L, Li M, Shen Z, Wang Y, ... Schofield CJ, et al. Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1. Scientific Reports. 7: 39392. PMID 28059088 DOI: 10.1038/srep39392  0.68
2016 Leśniak RK, Markolovic S, Tars K, Schofield CJ. Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N(ε)-trimethyllysine. Chemical Communications (Cambridge, England). PMID 27965989 DOI: 10.1039/c6cc08381a  0.72
2016 Bardella C, Al-Dalahmah O, Krell D, Brazauskas P, Al-Qahtani K, Tomkova M, Adam J, Serres S, Lockstone H, Freeman-Mills L, Pfeffer I, Sibson N, Goldin R, Schuster-Böeckler B, Pollard PJ, ... ... Schofield CJ, et al. Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis. Cancer Cell. PMID 27693047 DOI: 10.1016/j.ccell.2016.08.017  0.44
2016 Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW, Ratcliffe PJ, Claridge TD, Schofield CJ. Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nature Communications. 7: 12673. PMID 27561929 DOI: 10.1038/ncomms12673  1
2016 Koukourakis MI, Giatromanolaki A, Zois CE, Kalamida D, Pouliliou S, Karagounis IV, Yeh TL, Abboud MI, Claridge TD, Schofield CJ, Sivridis E, Simopoulos C, Tokmakidis SP, Harris AL. Normal tissue radioprotection by amifostine via Warburg-type effects. Scientific Reports. 6: 30986. PMID 27507219 DOI: 10.1038/srep30986  1
2016 Chan MC, Ilott NE, Schödel J, Sims D, Tumber A, Lippl K, Mole DR, Pugh CW, Ratcliffe PJ, Ponting CP, Schofield CJ. Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases. The Journal of Biological Chemistry. PMID 27502280 DOI: 10.1074/jbc.M116.749291  1
2016 Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ. Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates. Nature Communications. 7: 12406. PMID 27499424 DOI: 10.1038/ncomms12406  1
2016 Cahill ST, Tarhonskaya H, Rydzik AM, Flashman E, McDonough MA, Schofield CJ, Brem J. Use of ferrous iron by metallo-β-lactamases. Journal of Inorganic Biochemistry. PMID 27498591 DOI: 10.1016/j.jinorgbio.2016.07.013  1
2016 Salimraj R, Zhang L, Hinchliffe P, Wellington EM, Brem J, Schofield CJ, Gaze WH, Spencer J. Structural and Biochemical Characterization of Rm3, a SubClass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study. Antimicrobial Agents and Chemotherapy. PMID 27431213 DOI: 10.1128/AAC.00750-16  0.68
2016 Abboud MI, Damblon C, Brem J, Smargiasso N, Mercuri P, Gilbert B, Rydzik AM, Claridge TD, Schofield CJ, Frère JM. Interaction of Avibactam with Class B Metallo-β-lactamases. Antimicrobial Agents and Chemotherapy. PMID 27401561 DOI: 10.1128/AAC.00897-16  0.8
2016 Walport LJ, Hopkinson RJ, Chowdhury R, Schiller R, Ge W, Kawamura A, Schofield CJ. Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases. Nature Communications. 7: 11974. PMID 27337104 DOI: 10.1038/ncomms11974  1
2016 Wang DY, Abboud MI, Markoulides MS, Brem J, Schofield CJ. The road to avibactam - the first clinically useful non-β-lactam working somewhat like a β-lactam. Future Medicinal Chemistry. PMID 27327972 DOI: 10.4155/fmc-2016-0078  0.8
2016 Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, ... ... Schofield CJ, et al. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nature Cell Biology. PMID 27323329 DOI: 10.1038/ncb3376  0.72
2016 Markolovic S, Leissing TM, Chowdhury R, Wilkins SE, Lu X, Schofield CJ. Structure-function relationships of human JmjC oxygenases-demethylases versus hydroxylases. Current Opinion in Structural Biology. 41: 62-72. PMID 27309310 DOI: 10.1016/j.sbi.2016.05.013  1
2016 Calvopiña K, Umland KD, Rydzik AM, Hinchliffe P, Brem J, Spencer J, Schofield CJ, Avison MB. Sideromimic modification of Lactivicin dramatically increases potency against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Antimicrobial Agents and Chemotherapy. PMID 27139464 DOI: 10.1128/AAC.00371-16  1
2016 Lee SY, Brem J, Pettinati I, Claridge TD, Gileadi O, Schofield CJ, McHugh PJ. Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo. Chemical Communications (Cambridge, England). PMID 27121860 DOI: 10.1039/c6cc00529b  1
2016 Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC, Aksentijević D, Gildea OS, Stuckey DJ, Yeoh KK, Carr CA, Evans RD, Aasum E, ... Schofield CJ, et al. On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27103577 DOI: 10.1096/fj.201500094R  1
2016 Choi H, Paton RS, Park H, Schofield CJ. Investigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibition. Organic & Biomolecular Chemistry. PMID 27072755 DOI: 10.1039/c6ob00353b  0.56
2016 Wilkins SE, Abboud MI, Hancock RL, Schofield CJ. Targeting Protein-Protein Interactions in the HIF System. Chemmedchem. PMID 26997519 DOI: 10.1002/cmdc.201600012  0.8
2016 Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, ... ... Schofield CJ, et al. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science Translational Medicine. 8: 328ra29. PMID 26936506 DOI: 10.1126/scitranslmed.aac6008  1
2016 Pettinati I, Brem J, Lee SY, McHugh PJ, Schofield CJ. The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins. Trends in Biochemical Sciences. PMID 26805042 DOI: 10.1016/j.tibs.2015.12.007  1
2016 Chan MC, Holt-Martyn JP, Schofield CJ, Ratcliffe PJ. Pharmacological targeting of the HIF hydroxylases - a new field in medicine development. Molecular Aspects of Medicine. PMID 26791432 DOI: 10.1016/j.mam.2016.01.001  1
2016 Bavetsias V, Lanigan RM, Ruda GF, Atrash B, McLaughlin MG, Tumber A, Mok NY, Le Bihan YV, Dempster S, Boxall KJ, Jeganathan F, Hatch SB, Savitsky P, Velupillai S, Krojer T, ... ... Schofield CJ, et al. 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. Journal of Medicinal Chemistry. PMID 26741168 DOI: 10.1021/acs.jmedchem.5b01635  1
2016 Betts JW, Phee LM, Abdul Momin MHF, Umland KD, Brem J, Schofield CJ, Wareham DW. In vitro and in vivo activity of ML302F: A thioenolate inhibitor of VIM-subfamily metallo β-lactamases Medchemcomm. 7: 190-193. DOI: 10.1039/c5md00380f  1
2015 González MM, Kosmopoulou M, Mojica MF, Castillo V, Hinchliffe P, Pettinati I, Brem J, Schofield CJ, Mahler G, Bonomo RA, Llarrull LI, Spencer J, Vila AJ. Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase. Acs Infectious Diseases. 1: 544-54. PMID 27623409 DOI: 10.1021/acsinfecdis.5b00046  0.68
2015 Hamed RB, Gomez-Castellanos JR, Froese DS, Krysztofinska E, Yue WW, Schofield CJ. Use of Methylmalonyl-CoA epimerase in Enhancing Crotonase Stereoselectivity. Chembiochem : a European Journal of Chemical Biology. PMID 26716911 DOI: 10.1002/cbic.201500644  1
2015 McAllister TE, England KS, Hopkinson RJ, Brennan PE, Kawamura A, Schofield CJ. Recent Progress in Histone Demethylase Inhibitors. Journal of Medicinal Chemistry. PMID 26710088 DOI: 10.1021/acs.jmedchem.5b01758  1
2015 Hopkinson RJ, Leung IK, Smart TJ, Rose NR, Henry L, Claridge TD, Schofield CJ. Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans. Plos One. 10: e0145085. PMID 26675168 DOI: 10.1371/journal.pone.0145085  1
2015 Emir UE, Larkin SJ, de Pennington N, Voets N, Plaha P, Stacey R, Al-Qahtani K, Mccullagh J, Schofield CJ, Clare S, Jezzard P, Cadoux-Hudson T, Ansorge O. Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations. Cancer Research. PMID 26669865 DOI: 10.1158/0008-5472.CAN-15-0934  1
2015 Makena A, Düzgün AÖ, Brem J, McDonough MA, Rydzik AM, Abboud MI, Saral A, Çiçek AÇ, Sandalli C, Schofield CJ. Comparison of Verona Integron-Borne Metallo-β-lactamase Variants Reveals Differences in Stability and Inhibition Profiles. Antimicrobial Agents and Chemotherapy. PMID 26666919 DOI: 10.1128/AAC.01768-15  1
2015 Kamps JJ, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TD, Mecinović J. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26660433 DOI: 10.1002/chem.201503761  1
2015 Allerston CK, Lee SY, Newman JA, Schofield CJ, McHugh PJ, Gileadi O. The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. Nucleic Acids Research. PMID 26582912 DOI: 10.1093/nar/gkv1256  1
2015 Domene C, Jorgensen C, Vanommeslaeghe K, Schofield CJ, MacKerell A. Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor. Journal of Chemical Theory and Computation. 11: 3946-54. PMID 26574473 DOI: 10.1021/acs.jctc.5b00411  0.56
2015 Langley GW, Brinkø A, Münzel M, Walport LJ, Schofield CJ, Hopkinson RJ. Analysis of JmjC Demethylase-Catalysed Demethylation using Geometrically-Constrained Lysine Analogues. Acs Chemical Biology. PMID 26555343 DOI: 10.1021/acschembio.5b00738  0.8
2015 Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ. Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers. Antimicrobial Agents and Chemotherapy. PMID 26482303 DOI: 10.1128/AAC.01335-15  1
2015 Daoud H, Zhang D, McMurray F, Yu A, Luco SM, Vanstone J, Jarinova O, Carson N, Wickens J, Shishodia S, Choi H, McDonough MA, Schofield CJ, Harper ME, Dyment DA, et al. Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay. Journal of Medical Genetics. PMID 26378117 DOI: 10.1136/jmedgenet-2015-103399  1
2015 Longbotham JE, Levy C, Johannissen LO, Tarhonskaya H, Jiang S, Loenarz C, Flashman E, Hay S, Schofield CJ, Scrutton NS. Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase. Biochemistry. 54: 6093-105. PMID 26368022 DOI: 10.1021/acs.biochem.5b00789  0.44
2015 Thinnes CC, Tumber A, Yapp C, Scozzafava G, Yeh T, Chan MC, Tran TA, Hsu K, Tarhonskaya H, Walport LJ, Wilkins SE, Martinez ED, Müller S, Pugh CW, Ratcliffe PJ, ... ... Schofield CJ, et al. Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. Chemical Communications (Cambridge, England). 51: 15458-61. PMID 26345662 DOI: 10.1039/c5cc06095h  1
2015 Lercher L, Raj R, Patel NA, Price J, Mohammed S, Robinson CV, Schofield CJ, Davis BG. Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation. Nature Communications. 6: 7978. PMID 26305776 DOI: 10.1038/ncomms8978  0.4
2015 Al-Qahtani K, Jabeen B, Sekirnik R, Riaz N, Claridge TD, Schofield CJ, McCullagh JS. The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves. Phytochemistry. 117: 456-461. PMID 26196940 DOI: 10.1016/j.phytochem.2015.06.028  0.44
2015 Markolovic S, Wilkins SE, Schofield CJ. Protein Hydroxylation Catalyzed by 2-Oxoglutarate-Dependent Oxygenases. The Journal of Biological Chemistry. PMID 26152730 DOI: 10.1074/jbc.R115.662627  1
2015 Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, ... ... Schofield CJ, et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. Plos One. 10: e0132004. PMID 26147748 DOI: 10.1371/journal.pone.0132004  1
2015 Ghavami A, Labbé G, Brem J, Goodfellow VJ, Marrone L, Tanner CA, King DT, Lam M, Strynadka NC, Pillai DR, Siemann S, Spencer J, Schofield CJ, Dmitrienko GI. Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates. Analytical Biochemistry. PMID 26142222 DOI: 10.1016/j.ab.2015.06.032  1
2015 Tarhonskaya H, Hardy AP, Howe EA, Loik ND, Kramer HB, McCullagh JS, Schofield CJ, Flashman E. Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-Inducible Factor (FIH) as an Oxygen Sensor. The Journal of Biological Chemistry. PMID 26112411 DOI: 10.1074/jbc.M115.653014  1
2015 Plank M, Fischer R, Geoghegan V, Charles PD, Konietzny R, Acuto O, Pears C, Schofield CJ, Kessler BM. Expanding the yeast protein arginine methylome. Proteomics. PMID 26046779 DOI: 10.1002/pmic.201500032  0.44
2015 Böttger A, Islam MS, Chowdhury R, Schofield CJ, Wolf A. The oxygenase Jmjd6--a case study in conflicting assignments. The Biochemical Journal. 468: 191-202. PMID 25997831 DOI: 10.1042/BJ20150278  1
2015 McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD. Pharmacological inhibition of FTO. Plos One. 10: e0121829. PMID 25830347 DOI: 10.1371/journal.pone.0121829  1
2015 Tan SC, Gomes RS, Yeoh KK, Perbellini F, Malandraki-Miller S, Ambrose L, Heather LC, Faggian G, Schofield CJ, Davies KE, Clarke K, Carr CA. Preconditioning of cardiosphere-derived cells with hypoxia or prolyl-4-hydroxylase inhibitors increases stemness and decreases reliance on oxidative metabolism. Cell Transplantation. PMID 25751158 DOI: 10.3727/096368915X687697  1
2015 Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA. Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. Structure (London, England : 1993). 23: 639-52. PMID 25728928 DOI: 10.1016/j.str.2015.01.014  1
2015 Brem J, Struwe WB, Rydzik AM, Tarhonskaya H, Pfeffer I, Flashman E, van Berkel SS, Spencer J, Claridge TD, McDonough MA, Benesch JL, Schofield CJ. Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, (19)F-labelling, crystallisation, data collection, and structure determination, table of crystallographic data, table of crystallographic parameters and refinement statistics, figures showing binding mode and distances, procedures for mass spectrometry measurements, differential scanning fluorimetry measurements, stopped-flow measurements and other kinetics measurements. See DOI: 10.1039/c4sc01752hClick here for additional data file. Chemical Science (Royal Society of Chemistry : 2010). 6: 956-963. PMID 25717359 DOI: 10.1039/c4sc01752h  1
2015 Zafred D, Steiner B, Teufelberger AR, Hromic A, Karplus PA, Schofield CJ, Wallner S, Macheroux P. Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction. The Febs Journal. PMID 25619330 DOI: 10.1111/febs.13212  0.44
2015 Pettinati I, Brem J, McDonough MA, Schofield CJ. Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy. Human Molecular Genetics. 24: 2458-69. PMID 25596185 DOI: 10.1093/hmg/ddv007  1
2015 Yufa R, Krylova SM, Bruce C, Bagg EA, Schofield CJ, Krylov SN. Emulsion PCR significantly improves nonequilibrium capillary electrophoresis of equilibrium mixtures-based aptamer selection: allowing for efficient and rapid selection of aptamer to unmodified ABH2 protein. Analytical Chemistry. 87: 1411-9. PMID 25495441 DOI: 10.1021/ac5044187  1
2015 Michailidou Z, Morton NM, Moreno Navarrete JM, West CC, Stewart KJ, Fernández-Real JM, Schofield CJ, Seckl JR, Ratcliffe PJ. Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion. Diabetes. 64: 733-45. PMID 25377876 DOI: 10.2337/db14-0233  0.44
2015 Makena A, Brem J, Pfeffer I, Geffen RE, Wilkins SE, Tarhonskaya H, Flashman E, Phee LM, Wareham DW, Schofield CJ. Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability. The Journal of Antimicrobial Chemotherapy. 70: 463-9. PMID 25324420 DOI: 10.1093/jac/dku403  1
2015 Jayatunga MK, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, Hamilton AD. Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). European Journal of Medicinal Chemistry. 94: 509-16. PMID 25023609 DOI: 10.1016/j.ejmech.2014.06.006  1
2015 Hay DA, Rogers CM, Fedorov O, Tallant C, Martin S, Monteiro OP, Müller S, Knapp S, Schofield CJ, Brennan PE. Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains Medchemcomm. 6: 1381-1386. DOI: 10.1039/c5md00152h  0.44
2015 Wilkins SE, Flashman E, Scotti JS, Hopkinson RJ, Chowdhury R, Schofield CJ. The role of 2-oxoglutarate-dependent oxygenases in hypoxia sensing Rsc Metallobiology. 2015: 169-209. DOI: 10.1039/9781782621959-00169  1
2015 Aik WS, Chowdhury R, Clifton IJ, Hopkinson RJ, Leissing T, McDonough MA, Nowak R, Schofield CJ, Walport LJ. Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes Rsc Metallobiology. 2015: 59-94. DOI: 10.1039/9781782621959-00059  1
2015 Lercher L, Raj R, Patel NA, Price J, Mohammed S, Robinson CV, Schofield CJ, Davis BG. Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation Nature Communications. 6. DOI: 10.1038/ncomms8978  1
2015 Domene C, Jorgensen C, Vanommeslaeghe K, Schofield CJ, MacKerell A. Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor Journal of Chemical Theory and Computation. 11: 3946-3954. DOI: 10.1021/acs.jctc.5b00411  1
2014 Gardie B, Percy MJ, Hoogewijs D, Chowdhury R, Bento C, Arsenault PR, Richard S, Almeida H, Ewing J, Lambert F, McMullin MF, Schofield CJ, Lee FS. The role of PHD2 mutations in the pathogenesis of erythrocytosis. Hypoxia (Auckland, N.Z.). 2: 71-90. PMID 27774468 DOI: 10.2147/HP.S54455  1
2014 Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ. Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase. Chemical Science (Royal Society of Chemistry : 2010). 5: 1765-1771. PMID 26682037 DOI: 10.1039/C4SC00020J  1
2014 England KS, Tumber A, Krojer T, Scozzafava G, Ng SS, Daniel M, Szykowska A, Che K, von Delft F, Burgess-Brown NA, Kawamura A, Schofield CJ, Brennan PE. Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor. Medchemcomm. 5: 1879-1886. PMID 26682034 DOI: 10.1039/C4MD00291A  1
2014 Williams ST, Walport LJ, Hopkinson RJ, Madden SK, Chowdhury R, Schofield CJ, Kawamura A. Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates. Epigenetics. 9: 1596-603. PMID 25625844 DOI: 10.4161/15592294.2014.983381  0.68
2014 Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ. Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition. Nature Chemistry. 6: 1084-90. PMID 25411887 DOI: 10.1038/nchem.2110  1
2014 Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, ... ... Schofield CJ, et al. Kruidenier et al. reply. Nature. 514: E2. PMID 25279927 DOI: 10.1038/nature13689  1
2014 Rydzik AM, Brem J, Struwe WB, Kochan GT, Benesch JL, Schofield CJ. Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase. Bioorganic & Medicinal Chemistry Letters. 24: 4954-7. PMID 25266780 DOI: 10.1016/j.bmcl.2014.09.035  1
2014 Scotti JS, Leung IK, Ge W, Bentley MA, Paps J, Kramer HB, Lee J, Aik W, Choi H, Paulsen SM, Bowman LA, Loik ND, Horita S, Ho CH, Kershaw NJ, ... ... Schofield CJ, et al. Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. Proceedings of the National Academy of Sciences of the United States of America. 111: 13331-6. PMID 25197067 DOI: 10.1073/pnas.1409916111  1
2014 Rydzik AM, Leung IK, Kochan GT, McDonough MA, Claridge TD, Schofield CJ. Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids. Angewandte Chemie (International Ed. in English). 53: 10925-7. PMID 25164544 DOI: 10.1002/anie.201406125  1
2014 Tarhonskaya H, Chowdhury R, Leung IK, Loik ND, McCullagh JS, Claridge TD, Schofield CJ, Flashman E. Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen. The Biochemical Journal. 463: 363-72. PMID 25120187 DOI: 10.1042/BJ20140779  1
2014 Rydzik AM, Leung IK, Kochan GT, Loik ND, Henry L, McDonough MA, Claridge TD, Schofield CJ. Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase. Organic & Biomolecular Chemistry. 12: 6354-8. PMID 25030770 DOI: 10.1039/c4ob01167h  1
2014 Chen RL, Ogunshola OO, Yeoh KK, Jani A, Papadakis M, Nagel S, Schofield CJ, Buchan AM. HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice. Journal of Neurochemistry. PMID 24974727 DOI: 10.1111/jnc.12804  0.72
2014 Hay DA, Fedorov O, Martin S, Singleton DC, Tallant C, Wells C, Picaud S, Philpott M, Monteiro OP, Rogers CM, Conway SJ, Rooney TP, Tumber A, Yapp C, Filippakopoulos P, ... ... Schofield CJ, et al. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. Journal of the American Chemical Society. 136: 9308-19. PMID 24946055 DOI: 10.1021/ja412434f  1
2014 Heim A, Grimm C, Müller U, Häußler S, Mackeen MM, Merl J, Hauck SM, Kessler BM, Schofield CJ, Wolf A, Böttger A. Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins. Nucleic Acids Research. 42: 7833-50. PMID 24914048 DOI: 10.1093/nar/gku488  1
2014 Thinnes CC, England KS, Kawamura A, Chowdhury R, Schofield CJ, Hopkinson RJ. Targeting histone lysine demethylases - progress, challenges, and the future. Biochimica Et Biophysica Acta. 1839: 1416-32. PMID 24859458 DOI: 10.1016/j.bbagrm.2014.05.009  1
2014 Lu M, Zak J, Chen S, Sanchez-Pulido L, Severson DT, Endicott J, Ponting CP, Schofield CJ, Lu X. A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. Cell. 157: 1130-45. PMID 24855949 DOI: 10.1016/j.cell.2014.05.006  1
2014 Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JR, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, ... ... Schofield CJ, et al. Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature. 510: 422-6. PMID 24814345 DOI: 10.1038/nature13263  1
2014 Walport LJ, Hopkinson RJ, Vollmar M, Madden SK, Gileadi C, Oppermann U, Schofield CJ, Johansson C. Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase. The Journal of Biological Chemistry. 289: 18302-13. PMID 24798337 DOI: 10.1074/jbc.M114.555052  1
2014 Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. The Journal of Biological Chemistry. 289: 17299-311. PMID 24778178 DOI: 10.1074/jbc.M114.550350  1
2014 Tarhonskaya H, Szöllössi A, Leung IK, Bush JT, Henry L, Chowdhury R, Iqbal A, Claridge TD, Schofield CJ, Flashman E. Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases. Biochemistry. 53: 2483-93. PMID 24684493 DOI: 10.1021/bi500086p  1
2014 Rydzik AM, Brem J, van Berkel SS, Pfeffer I, Makena A, Claridge TD, Schofield CJ. Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy. Angewandte Chemie (International Ed. in English). 53: 3129-33. PMID 24615874 DOI: 10.1002/anie.201310866  1
2014 Tarhonskaya H, Rydzik AM, Leung IK, Loik ND, Chan MC, Kawamura A, McCullagh JS, Claridge TD, Flashman E, Schofield CJ. Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases. Nature Communications. 5: 3423. PMID 24594748 DOI: 10.1038/ncomms4423  1
2014 Snell CE, Turley H, McIntyre A, Li D, Masiero M, Schofield CJ, Gatter KC, Harris AL, Pezzella F. Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours. Plos One. 9: e88955. PMID 24563687 DOI: 10.1371/journal.pone.0088955  1
2014 Katz MJ, Acevedo JM, Loenarz C, Galagovsky D, Liu-Yi P, Pérez-Pepe M, Thalhammer A, Sekirnik R, Ge W, Melani M, Thomas MG, Simonetta S, Boccaccio GL, Schofield CJ, Cockman ME, et al. Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth. Proceedings of the National Academy of Sciences of the United States of America. 111: 4025-30. PMID 24550463 DOI: 10.1073/pnas.1314485111  1
2014 Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proceedings of the National Academy of Sciences of the United States of America. 111: 4019-24. PMID 24550462 DOI: 10.1073/pnas.1311750111  1
2014 Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, Yamamoto A, Coleman ML, Kessler BM, ... ... Schofield CJ, et al. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proceedings of the National Academy of Sciences of the United States of America. 111: 4031-6. PMID 24550447 DOI: 10.1073/pnas.1314482111  1
2014 Schiller R, Scozzafava G, Tumber A, Wickens JR, Bush JT, Rai G, Lejeune C, Choi H, Yeh TL, Chan MC, Mott BT, McCullagh JS, Maloney DJ, Schofield CJ, Kawamura A. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. Chemmedchem. 9: 566-71. PMID 24504543 DOI: 10.1002/cmdc.201300428  1
2014 Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA. Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Research. 42: 4741-54. PMID 24489119 DOI: 10.1093/nar/gku085  1
2014 Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Münzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schödel J, McCullagh JS, Ge W, ... ... Schofield CJ, et al. Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Molecular Cell. 53: 645-54. PMID 24486019 DOI: 10.1016/j.molcel.2013.12.028  1
2014 Rotili D, Tomassi S, Conte M, Benedetti R, Tortorici M, Ciossani G, Valente S, Marrocco B, Labella D, Novellino E, Mattevi A, Altucci L, Tumber A, Yapp C, King ON, ... ... Schofield CJ, et al. Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. Journal of Medicinal Chemistry. 57: 42-55. PMID 24325601 DOI: 10.1021/jm4012802  1
2014 Rydzik AM, Leung IK, Thalhammer A, Kochan GT, Claridge TD, Schofield CJ. Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications. Chemical Communications (Cambridge, England). 50: 1175-7. PMID 24317009 DOI: 10.1039/c3cc47581f  1
2014 Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ. Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chemical Communications (Cambridge, England). 50: 1794-6. PMID 24287551 DOI: 10.1039/c3cc48151d  1
2014 Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ. Modulating carnitine levels by targeting its biosynthesis-selective inhibition of γ-butyrobetaine hydroxylase Chemical Science. 5: 1765-1771. DOI: 10.1039/c4sc00020j  1
2014 Gruber T, Thompson AL, Odell B, Bombicz P, Schofield CJ. Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy New Journal of Chemistry. 38: 5905-5917. DOI: 10.1039/c4nj01339e  1
2014 England KS, Tumber A, Krojer T, Scozzafava G, Ng SS, Daniel M, Szykowska A, Che K, Von Delft F, Burgess-Brown NA, Kawamura A, Schofield CJ, Brennan PE. Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor Medchemcomm. 5: 1879-1886. DOI: 10.1039/c4md00291a  1
2013 Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JB, King ON, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... Schofield CJ, et al. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chemical Science (Royal Society of Chemistry : 2010). 4: 3110-3117. PMID 26682036 DOI: 10.1039/C3SC51122G  1
2013 Makena A, van Berkel SS, Lejeune C, Owens RJ, Verma A, Salimraj R, Spencer J, Brem J, Schofield CJ. Chromophore-linked substrate (CLS405): probing metallo-β-lactamase activity and inhibition. Chemmedchem. 8: 1923-9. PMID 24166830 DOI: 10.1002/cmdc.201300350  1
2013 Hamed RB, Henry L, Gomez-Castellanos JR, Asghar A, Brem J, Claridge TD, Schofield CJ. Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase. Organic & Biomolecular Chemistry. 11: 8191-6. PMID 24108359 DOI: 10.1039/c3ob41525b  1
2013 Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA, Brown R, Fuchter MJ. On the histone lysine methyltransferase activity of fungal metabolite chaetocin. Journal of Medicinal Chemistry. 56: 8616-25. PMID 24099080 DOI: 10.1021/jm401063r  1
2013 Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M, Tsukada Y, Tumber A, Nakagawa H, Hasegawa M, Sasaki R, ... ... Schofield CJ, et al. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. Journal of Medicinal Chemistry. 56: 7222-31. PMID 23964788 DOI: 10.1021/jm400624b  1
2013 Lercher L, McGouran JF, Kessler BM, Schofield CJ, Davis BG. DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes. Angewandte Chemie (International Ed. in English). 52: 10553-8. PMID 23943570 DOI: 10.1002/anie.201304038  1
2013 van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ. Binding of (5S)-penicilloic acid to penicillin binding protein 3. Acs Chemical Biology. 8: 2112-6. PMID 23899657 DOI: 10.1021/cb400200h  1
2013 van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. Assay platform for clinically relevant metallo-β-lactamases. Journal of Medicinal Chemistry. 56: 6945-53. PMID 23898798 DOI: 10.1021/jm400769b  1
2013 ValegÃ¥rd K, Iqbal A, Kershaw NJ, Ivison D, Généreux C, Dubus A, Blikstad C, Demetriades M, Hopkinson RJ, Lloyd AJ, Roper DI, Schofield CJ, Andersson I, McDonough MA. Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway. Acta Crystallographica. Section D, Biological Crystallography. 69: 1567-79. PMID 23897479 DOI: 10.1107/S0907444913011013  1
2013 Hopkinson RJ, Walport LJ, Münzel M, Rose NR, Smart TJ, Kawamura A, Claridge TD, Schofield CJ. Is JmjC oxygenase catalysis limited to demethylation? Angewandte Chemie (International Ed. in English). 52: 7709-13. PMID 23788451 DOI: 10.1002/anie.201303282  1
2013 Bishop T, Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G, Fielding JW, Smith TG, Demetriades M, Schofield CJ, Robbins PA, Pugh CW, Buckler KJ, Ratcliffe PJ. Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2. The Journal of Physiology. 591: 3565-77. PMID 23690557 DOI: 10.1113/jphysiol.2012.247254  1
2013 Wolf A, Mantri M, Heim A, Müller U, Fichter E, Mackeen MM, Schermelleh L, Dadie G, Leonhardt H, Vénien-Bryan C, Kessler BM, Schofield CJ, Böttger A. The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. The Biochemical Journal. 453: 357-70. PMID 23688307 DOI: 10.1042/BJ20130529  1
2013 Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, ... ... Schofield CJ, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. Acs Chemical Biology. 8: 1488-96. PMID 23683440 DOI: 10.1021/cb400088q  1
2013 Aik W, Demetriades M, Hamdan MK, Bagg EA, Yeoh KK, Lejeune C, Zhang Z, McDonough MA, Schofield CJ. Structural basis for inhibition of the fat mass and obesity associated protein (FTO). Journal of Medicinal Chemistry. 56: 3680-8. PMID 23547775 DOI: 10.1021/jm400193d  1
2013 Sarathi Addy P, Saha B, Pradeep Singh ND, Das AK, Bush JT, Lejeune C, Schofield CJ, Basak A. 1,3,5-Trisubstituted benzenes as fluorescent photoaffinity probes for human carbonic anhydrase II capture. Chemical Communications (Cambridge, England). 49: 1930-2. PMID 23364467 DOI: 10.1039/c3cc38251f  1
2013 Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ. Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. Angewandte Chemie (International Ed. in English). 52: 1700-4. PMID 23296631 DOI: 10.1002/anie.201208046  1
2013 Leung IK, Demetriades M, Hardy AP, Lejeune C, Smart TJ, Szöllössi A, Kawamura A, Schofield CJ, Claridge TD. Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. Journal of Medicinal Chemistry. 56: 547-55. PMID 23234607 DOI: 10.1021/jm301583m  1
2013 Yeoh KK, Chan MC, Thalhammer A, Demetriades M, Chowdhury R, Tian YM, Stolze I, McNeill LA, Lee MK, Woon EC, Mackeen MM, Kawamura A, Ratcliffe PJ, Mecinović J, Schofield CJ. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. Organic & Biomolecular Chemistry. 11: 732-45. PMID 23151668 DOI: 10.1039/c2ob26648b  1
2013 Hamed RB, Gomez-Castellanos JR, Henry L, Ducho C, McDonough MA, Schofield CJ. The enzymes of β-lactam biosynthesis. Natural Product Reports. 30: 21-107. PMID 23135477 DOI: 10.1039/c2np20065a  1
2013 Sánchez-Fernández EM, Tarhonskaya H, Al-Qahtani K, Hopkinson RJ, McCullagh JS, Schofield CJ, Flashman E. Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. The Biochemical Journal. 449: 491-6. PMID 23092293 DOI: 10.1042/BJ20121155  1
2013 Philip S, Howat I, Carson M, Booth A, Campbell K, Grant D, Patterson C, Schofield C, Bevan J, Patrick A, Leese G, Connell J. An audit of growth hormone replacement for GH-deficient adults in Scotland. Clinical Endocrinology. 78: 571-6. PMID 22901318 DOI: 10.1111/cen.12017  1
2013 Bush JT, Walport LJ, McGouran JF, Leung IKH, Berridge G, Van Berkel SS, Basak A, Kessler BM, Schofield CJ. The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes Chemical Science. 4: 4115-4120. DOI: 10.1039/c3sc51708j  1
2013 Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... Schofield CJ, et al. 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation Chemical Science. 4: 3110-3117. DOI: 10.1039/c3sc51122g  1
2013 Anderson HL, Lloyd-Jones GC, O'Brien P, Schofield CJ, Stephan DW, Nicolaou KC, Férey G, Meerholz K. New Fellows of the Royal Society: H. L. Anderson, G. C. Lloyd-Jones, P. O'Brien, C. J. Schofield, D. W. Stephan, K. C. Nicolaou / Lavoisier Medal: G. Férey / Richard Willstätter Lectureship: K. Meerholz Angewandte Chemie - International Edition. 52: 7071-7072. DOI: 10.1002/anie.201304013  1
2012 Aik W, McDonough MA, Thalhammer A, Chowdhury R, Schofield CJ. Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases. Current Opinion in Structural Biology. 22: 691-700. PMID 23142576 DOI: 10.1016/j.sbi.2012.10.001  1
2012 Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, Hamed RB, Chowdhury R, Gong L, ... ... Schofield CJ, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature Chemical Biology. 8: 960-2. PMID 23103944 DOI: 10.1038/nchembio.1093  1
2012 Walport LJ, Hopkinson RJ, Schofield CJ. Mechanisms of human histone and nucleic acid demethylases. Current Opinion in Chemical Biology. 16: 525-34. PMID 23063108 DOI: 10.1016/j.cbpa.2012.09.015  1
2012 Hewings DS, Rooney TP, Jennings LE, Hay DA, Schofield CJ, Brennan PE, Knapp S, Conway SJ. Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions. Journal of Medicinal Chemistry. 55: 9393-413. PMID 22924434 DOI: 10.1021/jm300915b  1
2012 Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, ... ... Schofield CJ, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 488: 404-8. PMID 22842901 DOI: 10.1038/nature11262  1
2012 Henry L, Leung IK, Claridge TD, Schofield CJ. γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement. Bioorganic & Medicinal Chemistry Letters. 22: 4975-8. PMID 22765904 DOI: 10.1016/j.bmcl.2012.06.024  1
2012 Rydzik AM, Leung IK, Kochan GT, Thalhammer A, Oppermann U, Claridge TD, Schofield CJ. Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase. Chembiochem : a European Journal of Chemical Biology. 13: 1559-63. PMID 22730246 DOI: 10.1002/cbic.201200256  1
2012 Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, ... ... Schofield CJ, et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of Medicinal Chemistry. 55: 6639-43. PMID 22724510 DOI: 10.1021/jm300677j  1
2012 Schofield C. Drug discovery: spread the risk of antibiotic research. Nature. 486: 323. PMID 22722179 DOI: 10.1038/486323c  1
2012 Sengerová B, Allerston CK, Abu M, Lee SY, Hartley J, Kiakos K, Schofield CJ, Hartley JA, Gileadi O, McHugh PJ. Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. The Journal of Biological Chemistry. 287: 26254-67. PMID 22692201 DOI: 10.1074/jbc.M112.367243  1
2012 Demetriades M, Leung IK, Chowdhury R, Chan MC, McDonough MA, Yeoh KK, Tian YM, Claridge TD, Ratcliffe PJ, Woon EC, Schofield CJ. Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. Angewandte Chemie (International Ed. in English). 51: 6672-5. PMID 22639232 DOI: 10.1002/anie.201202000  1
2012 Heather LC, Cole MA, Tan JJ, Ambrose LJ, Pope S, Abd-Jamil AH, Carter EE, Dodd MS, Yeoh KK, Schofield CJ, Clarke K. Metabolic adaptation to chronic hypoxia in cardiac mitochondria. Basic Research in Cardiology. 107: 268. PMID 22538979 DOI: 10.1007/s00395-012-0268-2  1
2012 Krylova SM, Koshkin V, Bagg E, Schofield CJ, Krylov SN. Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases. Journal of Medicinal Chemistry. 55: 3546-52. PMID 22471443 DOI: 10.1021/jm300243h  1
2012 Schofield CJ, Sutherland C. Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes. Diabetic Medicine : a Journal of the British Diabetic Association. 29: 972-9. PMID 22443306 DOI: 10.1111/j.1464-5491.2012.03655.x  1
2012 Gruber T, Schofield CJ, Thompson AL. 3-Meth-oxy-3-oxopropanaminium chloride. Acta Crystallographica. Section E, Structure Reports Online. 68: o595. PMID 22412509 DOI: 10.1107/S1600536812003297  1
2012 Gruber T, Schofield CJ, Thompson AL. Methyl 6-amino-6-oxohexa-noate. Acta Crystallographica. Section E, Structure Reports Online. 68: o593-4. PMID 22412508 DOI: 10.1107/S1600536812003303  1
2012 Lee W, Zeng X, Rotolo K, Yang M, Schofield CJ, Bennett V, Yang W, Marszalek PE. Mechanical anisotropy of ankyrin repeats. Biophysical Journal. 102: 1118-26. PMID 22404934 DOI: 10.1016/j.bpj.2012.01.046  1
2012 Masson N, Singleton RS, Sekirnik R, Trudgian DC, Ambrose LJ, Miranda MX, Tian YM, Kessler BM, Schofield CJ, Ratcliffe PJ. The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity. Embo Reports. 13: 251-7. PMID 22310300 DOI: 10.1038/embor.2012.9  1
2012 Woon EC, Demetriades M, Bagg EA, Aik W, Krylova SM, Ma JH, Chan M, Walport LJ, Wegman DW, Dack KN, McDonough MA, Krylov SN, Schofield CJ. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. Journal of Medicinal Chemistry. 55: 2173-84. PMID 22263962 DOI: 10.1021/jm201417e  1
2012 Mantri M, Zhang Z, McDonough MA, Schofield CJ. Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases. The Febs Journal. 279: 1563-75. PMID 22251775 DOI: 10.1111/j.1742-4658.2012.08496.x  1
2012 Chalker JM, Lercher L, Rose NR, Schofield CJ, Davis BG. Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications. Angewandte Chemie (International Ed. in English). 51: 1835-9. PMID 22247073 DOI: 10.1002/anie.201106432  1
2012 Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angewandte Chemie (International Ed. in English). 51: 1631-4. PMID 22241642 DOI: 10.1002/anie.201107833  1
2012 Hamed RB, Henry L, Gomez-Castellanos JR, Mecinović J, Ducho C, Sorensen JL, Claridge TD, Schofield CJ. Crotonase catalysis enables flexible production of functionalized prolines and carbapenams. Journal of the American Chemical Society. 134: 471-9. PMID 22091817 DOI: 10.1021/ja208318d  1
2012 Tan SC, Carr CA, Yeoh KK, Schofield CJ, Davies KE, Clarke K. Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors. Molecular Biology Reports. 39: 4857-67. PMID 22065248 DOI: 10.1007/s11033-011-1281-5  0.52
2012 Inglis SR, Strieker M, Rydzik AM, Dessen A, Schofield CJ. A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases. Analytical Biochemistry. 420: 41-7. PMID 21925482 DOI: 10.1016/j.ab.2011.08.036  1
2012 Mantri M, Webby CJ, Loik ND, Hamed RB, Nielsen ML, McDonough MA, McCullagh JSO, Böttger A, Schofield CJ, Wolf A. Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6 Medchemcomm. 3: 80-85. DOI: 10.1039/c1md00225b  1
2012 Thalhammer A, Aik W, Bagg EAL, Schofield CJ. The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets Drug Discovery Today: Therapeutic Strategies. 9: e91-e100. DOI: 10.1016/j.ddstr.2012.02.002  1
2011 Woon EC, Zervosen A, Sauvage E, Simmons KJ, Zivec M, Inglis SR, Fishwick CW, Gobec S, Charlier P, Luxen A, Schofield CJ. Structure guided development of potent reversibly binding penicillin binding protein inhibitors. Acs Medicinal Chemistry Letters. 2: 219-23. PMID 24900305 DOI: 10.1021/ml100260x  1
2011 Mantri M, Loik ND, Hamed RB, Claridge TD, McCullagh JS, Schofield CJ. The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues. Chembiochem : a European Journal of Chemical Biology. 12: 531-4. PMID 22238144 DOI: 10.1002/cbic.201000641  1
2011 Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. The Journal of Biological Chemistry. 286: 41616-25. PMID 21914792 DOI: 10.1074/jbc.M111.283689  1
2011 Wang AT, Sengerová B, Cattell E, Inagawa T, Hartley JM, Kiakos K, Burgess-Brown NA, Swift LP, Enzlin JH, Schofield CJ, Gileadi O, Hartley JA, McHugh PJ. Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes & Development. 25: 1859-70. PMID 21896658 DOI: 10.1101/gad.15699211  1
2011 Kawamura A, Loenarz C, Schofield CJ. Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry. Cell Cycle (Georgetown, Tex.). 10: 2819-20. PMID 21857150 DOI: 10.4161/cc.10.17.16745  1
2011 Iqbal A, Clifton IJ, Chowdhury R, Ivison D, Domene C, Schofield CJ. Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates. Organic & Biomolecular Chemistry. 9: 6219-25. PMID 21796301 DOI: 10.1039/c1ob05554b  1
2011 Contreras-Martel C, Amoroso A, Woon EC, Zervosen A, Inglis S, Martins A, Verlaine O, Rydzik AM, Job V, Luxen A, Joris B, Schofield CJ, Dessen A. Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA). Acs Chemical Biology. 6: 943-51. PMID 21732689 DOI: 10.1021/cb2001846  1
2011 Rotili D, Altun M, Kawamura A, Wolf A, Fischer R, Leung IK, Mackeen MM, Tian YM, Ratcliffe PJ, Mai A, Kessler BM, Schofield CJ. A photoreactive small-molecule probe for 2-oxoglutarate oxygenases. Chemistry & Biology. 18: 642-54. PMID 21609845 DOI: 10.1016/j.chembiol.2011.03.007  1
2011 Chowdhury R, Flashman E, Mecinović J, Kramer HB, Kessler BM, Frapart YM, Boucher JL, Clifton IJ, McDonough MA, Schofield CJ. Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). Journal of Molecular Biology. 410: 268-79. PMID 21601578 DOI: 10.1016/j.jmb.2011.04.075  1
2011 Zhang Z, Kochan GT, Ng SS, Kavanagh KL, Oppermann U, Schofield CJ, McDonough MA. Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. Biochemical and Biophysical Research Communications. 408: 553-8. PMID 21530488 DOI: 10.1016/j.bbrc.2011.04.059  1
2011 Hamed RB, Gomez-Castellanos JR, Thalhammer A, Harding D, Ducho C, Claridge TD, Schofield CJ. Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases. Nature Chemistry. 3: 365-71. PMID 21505494 DOI: 10.1038/nchem.1011  1
2011 Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, ... ... Schofield CJ, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. Embo Reports. 12: 463-9. PMID 21460794 DOI: 10.1038/embor.2011.43  1
2011 Thalhammer A, Hansen AS, El-Sagheer AH, Brown T, Schofield CJ. Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation. Chemical Communications (Cambridge, England). 47: 5325-7. PMID 21451870 DOI: 10.1039/c0cc05671e  1
2011 Chang KH, King ON, Tumber A, Woon EC, Heightman TD, McDonough MA, Schofield CJ, Rose NR. Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds. Chemmedchem. 6: 759-64. PMID 21412984 DOI: 10.1002/cmdc.201100026  1
2011 Krylova SM, Karkhanina AA, Musheev MU, Bagg EA, Schofield CJ, Krylov SN. DNA aptamers for as analytical tools for the quantitative analysis of DNA-dealkylating enzymes. Analytical Biochemistry. 414: 261-5. PMID 21402046 DOI: 10.1016/j.ab.2011.03.010  1
2011 Rose NR, McDonough MA, King ON, Kawamura A, Schofield CJ. Inhibition of 2-oxoglutarate dependent oxygenases. Chemical Society Reviews. 40: 4364-97. PMID 21390379 DOI: 10.1039/c0cs00203h  1
2011 Tian YM, Yeoh KK, Lee MK, Eriksson T, Kessler BM, Kramer HB, Edelmann MJ, Willam C, Pugh CW, Schofield CJ, Ratcliffe PJ. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. The Journal of Biological Chemistry. 286: 13041-51. PMID 21335549 DOI: 10.1074/jbc.M110.211110  1
2011 Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). Plos One. 6: e16210. PMID 21264265 DOI: 10.1371/journal.pone.0016210  1
2011 Hansen AS, Thalhammer A, El-Sagheer AH, Brown T, Schofield CJ. Improved synthesis of 5-hydroxymethyl-2'-deoxycytidine phosphoramidite using a 2'-deoxyuridine to 2'-deoxycytidine conversion without temporary protecting groups. Bioorganic & Medicinal Chemistry Letters. 21: 1181-4. PMID 21256007 DOI: 10.1016/j.bmcl.2010.12.098  1
2011 Yang M, Chowdhury R, Ge W, Hamed RB, McDonough MA, Claridge TD, Kessler BM, Cockman ME, Ratcliffe PJ, Schofield CJ. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. The Febs Journal. 278: 1086-97. PMID 21251231 DOI: 10.1111/j.1742-4658.2011.08022.x  1
2011 Yang M, Ge W, Chowdhury R, Claridge TD, Kramer HB, Schmierer B, McDonough MA, Gong L, Kessler BM, Ratcliffe PJ, Coleman ML, Schofield CJ. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry. 286: 7648-60. PMID 21177872 DOI: 10.1074/jbc.M110.193540  1
2011 Rotili D, Altun M, Hamed RB, Loenarz C, Thalhammer A, Hopkinson RJ, Tian YM, Ratcliffe PJ, Mai A, Kessler BM, Schofield CJ. Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions. Chemical Communications (Cambridge, England). 47: 1488-90. PMID 21152646 DOI: 10.1039/c0cc04457a  1
2011 Loenarz C, Coleman ML, Boleininger A, Schierwater B, Holland PW, Ratcliffe PJ, Schofield CJ. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. Embo Reports. 12: 63-70. PMID 21109780 DOI: 10.1038/embor.2010.170  1
2011 Thalhammer A, Mecinović J, Loenarz C, Tumber A, Rose NR, Heightman TD, Schofield CJ. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. Organic & Biomolecular Chemistry. 9: 127-35. PMID 21076780 DOI: 10.1039/c0ob00592d  1
2011 Astuti D, Ricketts CJ, Chowdhury R, McDonough MA, Gentle D, Kirby G, Schlisio S, Kenchappa RS, Carter BD, Kaelin WG, Ratcliffe PJ, Schofield CJ, Latif F, Maher ER. Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocrine-Related Cancer. 18: 73-83. PMID 20959442 DOI: 10.1677/ERC-10-0113  1
2011 Loenarz C, Schofield CJ. Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends in Biochemical Sciences. 36: 7-18. PMID 20728359 DOI: 10.1016/j.tibs.2010.07.002  1
2011 Chalker JM, Gunnoo SB, Boutureira O, Gerstberger SC, Fernández-González M, Bernardes GJL, Griffin L, Hailu H, Schofield CJ, Davis BG. Methods for converting cysteine to dehydroalanine on peptides and proteins Chemical Science. 2: 1666-1676. DOI: 10.1039/c1sc00185j  1
2011 Leung IKH, Brown T, Schofield CJ, Claridge TDW. An approach to enzyme inhibition employing reversible boronate ester formation Medchemcomm. 2: 390-395. DOI: 10.1039/c1md00011j  1
2010 Leung IK, Krojer TJ, Kochan GT, Henry L, von Delft F, Claridge TD, Oppermann U, McDonough MA, Schofield CJ. Structural and mechanistic studies on γ-butyrobetaine hydroxylase. Chemistry & Biology. 17: 1316-24. PMID 21168767 DOI: 10.1016/j.chembiol.2010.09.016  1
2010 King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, ... Schofield CJ, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. Plos One. 5: e15535. PMID 21124847 DOI: 10.1371/journal.pone.0015535  1
2010 Sekirnik R, Rose NR, Mecinović J, Schofield CJ. 2-Oxoglutarate oxygenases are inhibited by a range of transition metals. Metallomics : Integrated Biometal Science. 2: 397-9. PMID 21072385 DOI: 10.1039/c004952b  1
2010 Hahn P, Wegener I, Burrells A, Böse J, Wolf A, Erck C, Butler D, Schofield CJ, Böttger A, Lengeling A. Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. Plos One. 5: e13769. PMID 21060799 DOI: 10.1371/journal.pone.0013769  1
2010 Schmierer B, Novák B, Schofield CJ. Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model. Bmc Systems Biology. 4: 139. PMID 20955552 DOI: 10.1186/1752-0509-4-139  1
2010 McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ. Structural studies on human 2-oxoglutarate dependent oxygenases. Current Opinion in Structural Biology. 20: 659-72. PMID 20888218 DOI: 10.1016/j.sbi.2010.08.006  1
2010 Flashman E, Hoffart LM, Hamed RB, Bollinger JM, Krebs C, Schofield CJ. Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen. The Febs Journal. 277: 4089-99. PMID 20840591 DOI: 10.1111/j.1742-4658.2010.07804.x  0.96
2010 Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ. Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorganic & Medicinal Chemistry Letters. 20: 6125-8. PMID 20822901 DOI: 10.1016/j.bmcl.2010.08.032  1
2010 Hopkinson RJ, Barlow PS, Schofield CJ, Claridge TD. Studies on the reaction of glutathione and formaldehyde using NMR. Organic & Biomolecular Chemistry. 8: 4915-20. PMID 20737071 DOI: 10.1039/c0ob00208a  1
2010 Illingworth CJ, Loenarz C, Schofield CJ, Domene C. Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha. Biochemistry. 49: 6936-44. PMID 20695530 DOI: 10.1021/bi100358t  1
2010 Mantri M, Krojer T, Bagg EA, Webby CA, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ. Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6. Journal of Molecular Biology. PMID 20685276 DOI: 10.1016/j.jmb.2010.05.054  1
2010 Mantri M, Krojer T, Bagg EA, Webby CJ, Butler DS, Kochan G, Kavanagh KL, Oppermann U, McDonough MA, Schofield CJ. Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. Journal of Molecular Biology. 401: 211-22. PMID 20684070  1
2010 Logie L, Ruiz-Alcaraz AJ, Schofield CJ, Hundal HS, Feuerstein GZ, Brady JD, Crowther D, Tommasi AM, Grierson CE, Shepherd B, Morris AD, Hansen MK, Pearson E, Sutherland C. Generation, validation and humanisation of a novel insulin resistant cell model. Biochemical Pharmacology. 80: 1042-9. PMID 20599791 DOI: 10.1016/j.bcp.2010.06.011  1
2010 Brown T, Charlier P, Herman R, Schofield CJ, Sauvage E. Structural basis for the interaction of lactivicins with serine beta-lactamases. Journal of Medicinal Chemistry. 53: 5890-4. PMID 20593835 DOI: 10.1021/jm100437u  1
2010 Mackeen MM, Kramer HB, Chang KH, Coleman ML, Hopkinson RJ, Schofield CJ, Kessler BM. Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry. Journal of Proteome Research. 9: 4082-92. PMID 20583823 DOI: 10.1021/pr100269b  1
2010 Kim M, Abdi K, Lee G, Rabbi M, Lee W, Yang M, Schofield CJ, Bennett V, Marszalek PE. Fast and forceful refolding of stretched alpha-helical solenoid proteins. Biophysical Journal. 98: 3086-92. PMID 20550922 DOI: 10.1016/j.bpj.2010.02.054  1
2010 Hamed RB, Mecinović J, Ducho C, Claridge TD, Schofield CJ. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. Chemical Communications (Cambridge, England). 46: 1413-5. PMID 20162132 DOI: 10.1039/b924519g  1
2010 Hopkinson RJ, Hamed RB, Rose NR, Claridge TD, Schofield CJ. Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde. Chembiochem : a European Journal of Chemical Biology. 11: 506-10. PMID 20095001 DOI: 10.1002/cbic.200900713  1
2010 Sakurai M, Rose NR, Schultz L, Quinn AM, Jadhav A, Ng SS, Oppermann U, Schofield CJ, Simeonov A. A miniaturized screen for inhibitors of Jumonji histone demethylases. Molecular Biosystems. 6: 357-64. PMID 20094655 DOI: 10.1039/b912993f  1
2010 Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ. Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. Journal of Medicinal Chemistry. 53: 1810-8. PMID 20088513 DOI: 10.1021/jm901680b  1
2010 Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA. Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. Febs Letters. 584: 825-30. PMID 20067792 DOI: 10.1016/j.febslet.2009.12.055  1
2010 Flashman E, Davies SL, Yeoh KK, Schofield CJ. Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. The Biochemical Journal. 427: 135-42. PMID 20055761 DOI: 10.1042/BJ20091609  1
2010 Leung IK, Flashman E, Yeoh KK, Schofield CJ, Claridge TD. Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions. Journal of Medicinal Chemistry. 53: 867-75. PMID 20025281 DOI: 10.1021/jm901537q  0.84
2010 Inglis SR, Woon EC, Thompson AL, Schofield CJ. Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates. The Journal of Organic Chemistry. 75: 468-71. PMID 20014787 DOI: 10.1021/jo901930v  1
2010 Iqbal A, Arunlanantham H, Brown T, Chowdhury R, Clifton IJ, Kershaw NJ, Hewitson KS, McDonough MA, Schofield CJ. Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway. Proteins. 78: 1398-407. PMID 20014241 DOI: 10.1002/prot.22653  1
2010 Mackenzie AK, ValegÃ¥rd K, Iqbal A, Caines ME, Kershaw NJ, Jensen SE, Schofield CJ, Andersson I. Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid. Journal of Molecular Biology. 396: 332-44. PMID 19941870 DOI: 10.1016/j.jmb.2009.11.045  1
2010 Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Human Molecular Genetics. 19: 217-22. PMID 19843542 DOI: 10.1093/hmg/ddp480  1
2010 Nagel S, Talbot NP, Mecinović J, Smith TG, Buchan AM, Schofield CJ. Therapeutic manipulation of the HIF hydroxylases. Antioxidants & Redox Signaling. 12: 481-501. PMID 19754349 DOI: 10.1089/ars.2009.2711  1
2009 Sekirnik R, Rose NR, Thalhammer A, Seden PT, Mecinović J, Schofield CJ. Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II). Chemical Communications (Cambridge, England). 6376-8. PMID 19841782 DOI: 10.1039/b916357c  1
2009 Mecinović J, Loenarz C, Chowdhury R, Schofield CJ. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2. Bioorganic & Medicinal Chemistry Letters. 19: 6192-5. PMID 19775891 DOI: 10.1016/j.bmcl.2009.09.005  1
2009 Inglis SR, Zervosen A, Woon EC, Gerards T, Teller N, Fischer DS, Luxen A, Schofield CJ. Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. Journal of Medicinal Chemistry. 52: 6097-106. PMID 19731939 DOI: 10.1021/jm9009718  1
2009 Schofield CJ, Yu N, Jain AS, Leese GP. Decreasing amputation rates in patients with diabetes-a population-based study. Diabetic Medicine : a Journal of the British Diabetic Association. 26: 773-7. PMID 19709146 DOI: 10.1111/j.1464-5491.2009.02770.x  1
2009 Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T, Lee A, Moir L, Mecinović J, Quwailid MM, Schofield CJ, Ashcroft FM, Cox RD. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. Plos Genetics. 5: e1000599. PMID 19680540 DOI: 10.1371/journal.pgen.1000599  1
2009 Hardy AP, Prokes I, Kelly L, Campbell ID, Schofield CJ. Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function. Journal of Molecular Biology. 392: 994-1006. PMID 19646994 DOI: 10.1016/j.jmb.2009.07.070  1
2009 Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure (London, England : 1993). 17: 981-9. PMID 19604478 DOI: 10.1016/j.str.2009.06.002  1
2009 Cook KM, Hilton ST, Mecinovic J, Motherwell WB, Figg WD, Schofield CJ. Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism. The Journal of Biological Chemistry. 284: 26831-8. PMID 19589782 DOI: 10.1074/jbc.M109.009498  1
2009 Webby CJ, Wolf A, Gromak N, Dreger M, Kramer H, Kessler B, Nielsen ML, Schmitz C, Butler DS, Yates JR, Delahunty CM, Hahn P, Lengeling A, Mann M, Proudfoot NJ, ... Schofield CJ, et al. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science (New York, N.Y.). 325: 90-3. PMID 19574390 DOI: 10.1126/science.1175865  1
2009 Mecinović J, Chowdhury R, Flashman E, Schofield CJ. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2. Analytical Biochemistry. 393: 215-21. PMID 19563769 DOI: 10.1016/j.ab.2009.06.029  1
2009 Loenarz C, Schofield CJ. Oxygenase catalyzed 5-methylcytosine hydroxylation. Chemistry & Biology. 16: 580-3. PMID 19549596 DOI: 10.1016/j.chembiol.2009.06.002  1
2009 Ducho C, Hamed RB, Batchelar ET, Sorensen JL, Odell B, Schofield CJ. Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis. Organic & Biomolecular Chemistry. 7: 2770-9. PMID 19532994 DOI: 10.1039/b903312b  1
2009 Karkhanina AA, Mecinović J, Musheev MU, Krylova SM, Petrov AP, Hewitson KS, Flashman E, Schofield CJ, Krylov SN. Direct analysis of enzyme-catalyzed DNA demethylation. Analytical Chemistry. 81: 5871-5. PMID 19518090 DOI: 10.1021/ac9010556  0.84
2009 Caines ME, Sorensen JL, Schofield CJ. Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase. Biochemical and Biophysical Research Communications. 385: 512-7. PMID 19477162 DOI: 10.1016/j.bbrc.2009.05.095  1
2009 Stubbs CJ, Loenarz C, Mecinović J, Yeoh KK, Hindley N, Liénard BM, Sobott F, Schofield CJ, Flashman E. Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure. Journal of Medicinal Chemistry. 52: 2799-805. PMID 19364117 DOI: 10.1021/jm900285r  1
2009 Mecinović J, Hamed RB, Schofield CJ. Iron-mediated cleavage of C-C bonds in vicinal tricarbonyl compounds in water. Angewandte Chemie (International Ed. in English). 48: 2796-800. PMID 19280617 DOI: 10.1002/anie.200806296  1
2009 Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ. Evidence for a stereoelectronic effect in human oxygen sensing. Angewandte Chemie (International Ed. in English). 48: 1784-7. PMID 19180614 DOI: 10.1002/anie.200805427  1
2009 Iqbal A, Clifton IJ, Bagonis M, Kershaw NJ, Domene C, Claridge TD, Wharton CW, Schofield CJ. Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase. Journal of the American Chemical Society. 131: 749-57. PMID 19105697 DOI: 10.1021/ja807215u  1
2009 Hamed RB, Batchelar ET, Mecinović J, Claridge TD, Schofield CJ. Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline. Chembiochem : a European Journal of Chemical Biology. 10: 246-50. PMID 19090510 DOI: 10.1002/cbic.200800652  1
2009 Kelly L, McDonough MA, Coleman ML, Ratcliffe PJ, Schofield CJ. Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. Molecular Biosystems. 5: 52-8. PMID 19081931 DOI: 10.1039/b815271c  1
2009 Thalhammer A, Mecinović J, Schofield CJ. Triflic anhydride-mediated synthesis of oxazoles Tetrahedron Letters. 50: 1045-1047. DOI: 10.1016/j.tetlet.2008.12.080  1
2008 Kaewpet M, Odell B, King MA, Banerji B, Schofield CJ, Claridge TD. Synthesis and conformational analysis of cyclic analogues of inverse gamma-turns. Organic & Biomolecular Chemistry. 6: 3476-85. PMID 19082148 DOI: 10.1039/b808954j  1
2008 Lienard BM, Conejo-García A, Stolze I, Loenarz C, Oldham NJ, Ratcliffe PJ, Schofield CJ. Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases. Chemical Communications (Cambridge, England). 6393-5. PMID 19048166 DOI: 10.1039/b814440k  1
2008 Batchelar ET, Hamed RB, Ducho C, Claridge TD, Edelmann MJ, Kessler B, Schofield CJ. Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily. Angewandte Chemie (International Ed. in English). 47: 9322-5. PMID 18972478 DOI: 10.1002/anie.200803906  1
2008 Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. Journal of Medicinal Chemistry. 51: 7053-6. PMID 18942826 DOI: 10.1021/jm800936s  1
2008 Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. The Biochemical Journal. 416: 387-94. PMID 18713068 DOI: 10.1042/BJ20081238  1
2008 Bleijlevens B, Shivarattan T, Flashman E, Yang Y, Simpson PJ, Koivisto P, Sedgwick B, Schofield CJ, Matthews SJ. Dynamic states of the DNA repair enzyme AlkB regulate product release. Embo Reports. 9: 872-7. PMID 18617893 DOI: 10.1038/embor.2008.120  1
2008 Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA. Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). The Journal of Biological Chemistry. 283: 25971-8. PMID 18611856 DOI: 10.1074/jbc.M804999200  1
2008 Chowdhury R, Hardy A, Schofield CJ. The human oxygen sensing machinery and its manipulation. Chemical Society Reviews. 37: 1308-19. PMID 18568157 DOI: 10.1039/b701676j  1
2008 Hamed RB, Batchelar ET, Clifton IJ, Schofield CJ. Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity. Cellular and Molecular Life Sciences : Cmls. 65: 2507-27. PMID 18470480 DOI: 10.1007/s00018-008-8082-6  1
2008 Loenarz C, Schofield CJ. Expanding chemical biology of 2-oxoglutarate oxygenases. Nature Chemical Biology. 4: 152-6. PMID 18277970 DOI: 10.1038/nchembio0308-152  1
2008 Schofield CJ, Ellis JD, Ellingford A, Morris AD, Leese GP. Macular oedema is not predicted by perifoveal single blot haemorrhages. Diabetic Medicine : a Journal of the British Diabetic Association. 25: 129-33. PMID 18201214 DOI: 10.1111/j.1464-5491.2007.02330.x  1
2008 Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. The Journal of Biological Chemistry. 283: 3808-15. PMID 18063574 DOI: 10.1074/jbc.M707411200  1
2008 Mecinović J, Chowdhury R, Liénard BM, Flashman E, Buck MR, Oldham NJ, Schofield CJ. ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site. Chemmedchem. 3: 569-72. PMID 18058781 DOI: 10.1002/cmdc.200700233  1
2008 Hazrati A, Ramis-Castelltort M, Sarkar S, Barber LJ, Schofield CJ, Hartley JA, McHugh PJ. Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. Dna Repair. 7: 230-8. PMID 18006388 DOI: 10.1016/j.dnarep.2007.09.013  1
2008 Cook KM, Schofield CJ. Therapeutic strategies that target the HIF system Angiogenesis: An Integrative Approach From Science to Medicine. 359-373. DOI: 10.1007/978-0-387-71518-6_32  1
2008 Leese GP, Schofield CJ. Amputations in diabetes: A changing scene Practical Diabetes International. 25: 297-299. DOI: 10.1002/pdi.1282  1
2007 Hewitson KS, Schofield CJ, Ratcliffe PJ. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2. Methods in Enzymology. 435: 25-42. PMID 17998047 DOI: 10.1016/S0076-6879(07)35002-7  0.8
2007 Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, ... ... Schofield CJ, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (New York, N.Y.). 318: 1469-72. PMID 17991826 DOI: 10.1126/science.1151710  1
2007 Schofield CJ, McDonough MA. Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH). Biochemical Society Transactions. 35: 870-5. PMID 17956235 DOI: 10.1042/BST0350870  1
2007 Macheboeuf P, Fischer DS, Brown T, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ. Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nature Chemical Biology. 3: 565-9. PMID 17676039 DOI: 10.1038/nchembio.2007.21  0.52
2007 Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, ... Schofield CJ, et al. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature. 448: 87-91. PMID 17589501 DOI: 10.1038/nature05971  1
2007 Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry. 282: 24027-38. PMID 17573339 DOI: 10.1074/jbc.M704102200  1
2007 Borowski T, de Marothy S, Broclawik E, Schofield CJ, Siegbahn PE. Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies. Biochemistry. 46: 3682-91. PMID 17323933 DOI: 10.1021/bi602458m  1
2007 Horsfall LE, Garau G, Liénard BM, Dideberg O, Schofield CJ, Frère JM, Galleni M. Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila. Antimicrobial Agents and Chemotherapy. 51: 2136-42. PMID 17307979 DOI: 10.1128/AAC.00866-06  0.48
2007 MacKenzie AK, Kershaw NJ, Hernandez H, Robinson CV, Schofield CJ, Andersson I. Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid. Biochemistry. 46: 1523-33. PMID 17279617 DOI: 10.1021/bi061978x  0.52
2007 Flashman E, Schofield CJ. The most versatile of all reactive intermediates? Nature Chemical Biology. 3: 86-7. PMID 17235343 DOI: 10.1038/nchembio0207-86  0.84
2007 Liénard BM, Selevsek N, Oldham NJ, Schofield CJ. Combined mass spectrometry and dynamic chemistry approach to identify metalloenzyme inhibitors. Chemmedchem. 2: 175-9. PMID 17206734 DOI: 10.1002/cmdc.200600250  1
2007 Liénard BM, Horsfall LE, Galleni M, Frère JM, Schofield CJ. Inhibitors of the FEZ-1 metallo-beta-lactamase. Bioorganic & Medicinal Chemistry Letters. 17: 964-8. PMID 17157014 DOI: 10.1016/j.bmcl.2006.11.053  0.48
2007 Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. The Journal of Biological Chemistry. 282: 3293-301. PMID 17135241 DOI: 10.1074/jbc.M608337200  1
2007 Ehrismann D, Flashman E, Genn DN, Mathioudakis N, Hewitson KS, Ratcliffe PJ, Schofield CJ. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. The Biochemical Journal. 401: 227-34. PMID 16952279 DOI: 10.1042/BJ20061151  0.84
2006 Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proceedings of the National Academy of Sciences of the United States of America. 103: 14767-72. PMID 17003112 DOI: 10.1073/pnas.0606877103  1
2006 Bassan A, Borowski T, Schofield CJ, Siegbahn PE. Ethylene biosynthesis by 1-aminocyclopropane-1-carboxylic acid oxidase: a DFT study. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 8835-46. PMID 16933342 DOI: 10.1002/chem.200501459  1
2006 McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, ... ... Schofield CJ, et al. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proceedings of the National Academy of Sciences of the United States of America. 103: 9814-9. PMID 16782814 DOI: 10.1073/pnas.0601283103  1
2006 Liu B, Schofield CJ, Wilmouth RC. Structural analyses on intermediates in serine protease catalysis. The Journal of Biological Chemistry. 281: 24024-35. PMID 16754679 DOI: 10.1074/jbc.M600495200  0.64
2006 Selevsek N, Tholey A, Heinzle E, Liénard BM, Oldham NJ, Schofield CJ, Heinz U, Adolph HW, Frère JM. Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry. Journal of the American Society For Mass Spectrometry. 17: 1000-4. PMID 16713713 DOI: 10.1016/j.jasms.2006.03.010  1
2006 Borowski T, Broclawik E, Schofield CJ, Siegbahn PE. Epimerization and desaturation by carbapenem synthase (CarC). A hybrid DFT study. Journal of Computational Chemistry. 27: 740-8. PMID 16521121 DOI: 10.1002/jcc.20384  1
2006 Clifton IJ, McDonough MA, Ehrismann D, Kershaw NJ, Granatino N, Schofield CJ. Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. Journal of Inorganic Biochemistry. 100: 644-69. PMID 16513174 DOI: 10.1016/j.jinorgbio.2006.01.024  1
2006 Murray-Rust TA, Oldham NJ, Hewitson KS, Schofield CJ. Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro. Febs Letters. 580: 1911-8. PMID 16500650 DOI: 10.1016/j.febslet.2006.02.012  1
2006 Arulanantham H, Kershaw NJ, Hewitson KS, Hughes CE, Thirkettle JE, Schofield CJ. ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid. The Journal of Biological Chemistry. 281: 279-87. PMID 16251194 DOI: 10.1074/jbc.M507711200  0.8
2005 McNeill LA, Flashman E, Buck MR, Hewitson KS, Clifton IJ, Jeschke G, Claridge TD, Ehrismann D, Oldham NJ, Schofield CJ. Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate. Molecular Biosystems. 1: 321-4. PMID 16880998 DOI: 10.1039/b511249b  1
2005 Banerji B, Conejo-Garcia A, McNeill LA, McDonough MA, Buck MR, Hewitson KS, Oldham NJ, Schofield CJ. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. Chemical Communications (Cambridge, England). 5438-40. PMID 16261239 DOI: 10.1039/b510707e  1
2005 McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ. Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. The Journal of Biological Chemistry. 280: 41101-10. PMID 16186124 DOI: 10.1074/jbc.M507528200  1
2005 Welford RW, Kirkpatrick JM, McNeill LA, Puri M, Oldham NJ, Schofield CJ. Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans. Febs Letters. 579: 5170-4. PMID 16153644 DOI: 10.1016/j.febslet.2005.08.033  1
2005 Schofield CJ, Ratcliffe PJ. Signalling hypoxia by HIF hydroxylases. Biochemical and Biophysical Research Communications. 338: 617-26. PMID 16139242 DOI: 10.1016/j.bbrc.2005.08.111  0.44
2005 Kershaw NJ, Caines ME, Sleeman MC, Schofield CJ. The enzymology of clavam and carbapenem biosynthesis. Chemical Communications (Cambridge, England). 4251-63. PMID 16113715 DOI: 10.1039/b505964j  0.84
2005 Welford RW, Clifton IJ, Turnbull JJ, Wilson SC, Schofield CJ. Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism. Organic & Biomolecular Chemistry. 3: 3117-26. PMID 16106293 DOI: 10.1039/b507153d  1
2005 Sleeman MC, Sorensen JL, Batchelar ET, McDonough MA, Schofield CJ. Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis. The Journal of Biological Chemistry. 280: 34956-65. PMID 16096274 DOI: 10.1074/jbc.M507196200  1
2005 Conejo-Garcia A, Schofield CJ. A prodrug system for hydroxylamines based on esterase catalysis. Bioorganic & Medicinal Chemistry Letters. 15: 4004-9. PMID 15990293 DOI: 10.1016/j.bmcl.2005.06.026  0.76
2005 Searls T, Butler D, Chien W, Mukherji M, Lloyd MD, Schofield CJ. Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands. Journal of Lipid Research. 46: 1660-7. PMID 15930519 DOI: 10.1194/jlr.M500034-JLR200  0.6
2005 McDonough MA, McNeill LA, Tilliet M, Papamicaël CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ. Selective inhibition of factor inhibiting hypoxia-inducible factor. Journal of the American Chemical Society. 127: 7680-1. PMID 15913349 DOI: 10.1021/ja050841b  1
2005 Hewitson KS, Granatino N, Welford RW, McDonough MA, Schofield CJ. Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 363: 807-28; discussion 1. PMID 15901537 DOI: 10.1098/rsta.2004.1540  1
2005 Long AJ, Clifton IJ, Roach PL, Baldwin JE, Rutledge PJ, Schofield CJ. Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine. Biochemistry. 44: 6619-28. PMID 15850395 DOI: 10.1021/bi047478q  1
2005 Sorensen JL, Sleeman MC, Schofield CJ. Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis. Chemical Communications (Cambridge, England). 1155-7. PMID 15726176 DOI: 10.1039/b416423g  0.84
2005 Flashman E, McDonough MA, Schofield CJ. OS-9: another piece in the HIF complex story. Molecular Cell. 17: 472-3. PMID 15721249 DOI: 10.1016/j.molcel.2005.02.001  1
2005 Chapman TM, Davies IG, Gu B, Block TM, Scopes DI, Hay PA, Courtney SM, McNeill LA, Schofield CJ, Davis BG. Glyco- and peptidomimetics from three-component Joullié-Ugi coupling show selective antiviral activity. Journal of the American Chemical Society. 127: 506-7. PMID 15643858 DOI: 10.1021/ja043924l  1
2005 Elkins JM, Kershaw NJ, Schofield CJ. X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster. The Biochemical Journal. 385: 565-73. PMID 15352873 DOI: 10.1042/BJ20040814  0.52
2004 Zhang Z, Ren JS, Clifton IJ, Schofield CJ. Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme. Chemistry & Biology. 11: 1383-94. PMID 15489165 DOI: 10.1016/j.chembiol.2004.08.012  1
2004 Hewitson KS, Schofield CJ. The HIF pathway as a therapeutic target. Drug Discovery Today. 9: 704-11. PMID 15341784 DOI: 10.1016/S1359-6446(04)03202-7  0.8
2004 Topf M, Sandala GM, Smith DM, Schofield CJ, Easton CJ, Radom L. The unusual bifunctional catalysis of epimerization and desaturation by carbapenem synthase. Journal of the American Chemical Society. 126: 9932-3. PMID 15303862 DOI: 10.1021/ja047899v  1
2004 Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. The Biochemical Journal. 383: 429-37. PMID 15239670 DOI: 10.1042/BJ20040735  1
2004 Sleeman MC, Smith P, Kellam B, Chhabra SR, Bycroft BW, Schofield CJ. Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC). Chembiochem : a European Journal of Chemical Biology. 5: 879-82. PMID 15174175 DOI: 10.1002/cbic.200300908  0.84
2004 Schofield CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nature Reviews. Molecular Cell Biology. 5: 343-54. PMID 15122348 DOI: 10.1038/nrm1366  0.44
2004 Tsang WY, Dhanda A, Schofield CJ, Frère JM, Galleni M, Page MI. The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives. Bioorganic & Medicinal Chemistry Letters. 14: 1737-9. PMID 15026061 DOI: 10.1016/j.bmcl.2004.01.047  1
2004 Lloyd MD, Lipscomb SJ, Hewitson KS, Hensgens CM, Baldwin JE, Schofield CJ. Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase. The Journal of Biological Chemistry. 279: 15420-6. PMID 14734549 DOI: 10.1074/jbc.M313928200  1
2004 Tsang WY, Dhanda A, Schofield CJ, Page MI, Dhanda A. Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporins. The Journal of Organic Chemistry. 69: 339-44. PMID 14725445 DOI: 10.1021/jo035471t  1
2004 Sleeman MC, Schofield CJ. Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis. The Journal of Biological Chemistry. 279: 6730-6. PMID 14625287 DOI: 10.1074/jbc.M311824200  0.84
2003 Lloyd MD, Mukherji M, Kershaw NJ, Chien W, Wierzbicki AS, Schofield CJ. Role of phytanoyl-CoA 2-hydroxylase in phytanic acid metabolism. Advances in Experimental Medicine and Biology. 544: 303-4. PMID 14713244  0.52
2003 Turnbull JJ, Nagle MJ, Seibel JF, Welford RW, Grant GH, Schofield CJ. The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity. Bioorganic & Medicinal Chemistry Letters. 13: 3853-7. PMID 14552794 DOI: 10.1016/S0960-894X(03)00711-X  1
2003 Long AJ, Clifton IJ, Roach PL, Baldwin JE, Schofield CJ, Rutledge PJ. Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate. The Biochemical Journal. 372: 687-93. PMID 12622704 DOI: 10.1042/BJ20021627  1
2003 Clifton IJ, Doan LX, Sleeman MC, Topf M, Suzuki H, Wilmouth RC, Schofield CJ. Crystal structure of carbapenem synthase (CarC). The Journal of Biological Chemistry. 278: 20843-50. PMID 12611886 DOI: 10.1074/jbc.M213054200  1
2003 Seibel J, Brown D, Amour A, Macdonald SJ, Oldham NJ, Schofield CJ. Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 387-9. PMID 12565935 DOI: 10.1016/S0960-894X(02)00995-2  1
2003 Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. The Journal of Biological Chemistry. 278: 1802-6. PMID 12446723 DOI: 10.1074/jbc.C200644200  1
2002 McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE, Schofield CJ. Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. The Biochemical Journal. 367: 571-5. PMID 12215170 DOI: 10.1042/BJ20021162  1
2002 Zhang Z, Ren Js, Harlos K, McKinnon CH, Clifton IJ, Schofield CJ. Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements. Febs Letters. 517: 7-12. PMID 12062399 DOI: 10.1016/S0014-5793(02)02520-6  1
2002 Lipscomb SJ, Lee HJ, Mukherji M, Baldwin JE, Schofield CJ, Lloyd MD. The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase. European Journal of Biochemistry / Febs. 269: 2735-9. PMID 12047382 DOI: 10.1046/j.1432-1033.2002.02945.x  1
2002 Elkins JM, Clifton IJ, Hernández H, Doan LX, Robinson CV, Schofield CJ, Hewitson KS. Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis. The Biochemical Journal. 366: 423-34. PMID 12020346 DOI: 10.1042/BJ20020125  1
2002 Wilmouth RC, Turnbull JJ, Welford RW, Clifton IJ, Prescott AG, Schofield CJ. Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana. Structure (London, England : 1993). 10: 93-103. PMID 11796114 DOI: 10.1016/S0969-2126(01)00695-5  1
2001 Clifton IJ, Hsueh LC, Baldwin JE, Harlos K, Schofield CJ. Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases. European Journal of Biochemistry / Febs. 268: 6625-36. PMID 11737217 DOI: 10.1046/j.0014-2956.2001.02617.x  1
2001 Mukherji M, Chien W, Kershaw NJ, Clifton IJ, Schofield CJ, Wierzbicki AS, Lloyd MD. Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease. Human Molecular Genetics. 10: 1971-82. PMID 11555634  1
2001 Wilmouth RC, Edman K, Neutze R, Wright PA, Clifton IJ, Schneider TR, Schofield CJ, Hajdu J. X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate. Nature Structural Biology. 8: 689-94. PMID 11473259 DOI: 10.1038/90401  1
2001 Dubus A, Lloyd MD, Lee HJ, Schofield CJ, Baldwin JE, Frere JM. Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase. Cellular and Molecular Life Sciences : Cmls. 58: 835-43. PMID 11437242  1
2001 Wright PA, Wilmouth RC, Clifton IJ, Schofield CJ. Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein. European Journal of Biochemistry / Febs. 268: 2969-74. PMID 11358514 DOI: 10.1046/j.1432-1327.2001.02186.x  1
2001 Lee HJ, Lloyd MD, Harlos K, Clifton IJ, Baldwin JE, Schofield CJ. Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS). Journal of Molecular Biology. 308: 937-48. PMID 11352583 DOI: 10.1006/jmbi.2001.4649  1
2001 Lee HJ, Lloyd MD, Clifton IJ, Harlos K, Dubus A, Baldwin JE, Frere JM, Schofield CJ. Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258. The Journal of Biological Chemistry. 276: 18290-5. PMID 11279000 DOI: 10.1074/jbc.M100085200  1
2000 Dubus A, Sami M, Brown TJ, Schofield CJ, Baldwin JE, Frère JM. Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay. Febs Letters. 485: 142-6. PMID 11094156  1
2000 Wright PA, Wilmouth RC, Clifton IJ, Schofield CJ. 'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes. The Biochemical Journal. 351: 335-40. PMID 11023818 DOI: 10.1042/0264-6021:3510335  1
2000 Zhang Z, Ren J, Stammers DK, Baldwin JE, Harlos K, Schofield CJ. Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase. Nature Structural Biology. 7: 127-33. PMID 10655615 DOI: 10.1038/72398  0.84
1999 Lloyd MD, Lee HJ, Harlos K, Zhang ZH, Baldwin JE, Schofield CJ, Charnock JM, Garner CD, Hara T, Terwisscha van Scheltinga AC, Valegård K, Viklund JA, Hajdu J, Andersson I, Danielsson A, et al. Studies on the active site of deacetoxycephalosporin C synthase. Journal of Molecular Biology. 287: 943-60. PMID 10222202 DOI: 10.1006/jmbi.1999.2594  1
1998 Wilmouth RC, Westwood NJ, Anderson K, Brownlee W, Claridge TD, Clifton IJ, Pritchard GJ, Aplin RT, Schofield CJ. Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex. Biochemistry. 37: 17506-13. PMID 9860865 DOI: 10.1021/bi9816249  1
1998 Valegård K, van Scheltinga AC, Lloyd MD, Hara T, Ramaswamy S, Perrakis A, Thompson A, Lee HJ, Baldwin JE, Schofield CJ, Hajdu J, Andersson I. Structure of a cephalosporin synthase. Nature. 394: 805-9. PMID 9723623 DOI: 10.1038/29575  1
1997 Byford MF, Baldwin JE, Shiau CY, Schofield CJ. The Mechanism of ACV Synthetase. Chemical Reviews. 97: 2631-2650. PMID 11851475  0.84
1997 Schofield CJ, Baldwin JE, Byford MF, Clifton I, Hajdu J, Hensgens C, Roach P. Proteins of the penicillin biosynthesis pathway. Current Opinion in Structural Biology. 7: 857-64. PMID 9434907 DOI: 10.1016/S0959-440X(97)80158-3  1
1997 Zhang Z, Barlow JN, Baldwin JE, Schofield CJ. Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase. Biochemistry. 36: 15999-6007. PMID 9398335 DOI: 10.1021/bi971823c  1
1997 Shiau CY, Byford MF, Aplin RT, Baldwin JE, Schofield CJ. L-delta-(alpha-Aminoadipoyl)-L-cysteinyl-D-valine synthetase: thioesterification of valine is not obligatory for peptide bond formation. Biochemistry. 36: 8798-806. PMID 9220966 DOI: 10.1021/bi962932e  0.84
1997 Roach PL, Clifton IJ, Hensgens CM, Shibata N, Schofield CJ, Hajdu J, Baldwin JE. Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature. 387: 827-30. PMID 9194566 DOI: 10.1038/42990  1
1997 Wilmouth RC, Clifton IJ, Robinson CV, Roach PL, Aplin RT, Westwood NJ, Hajdu J, Schofield CJ. Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase. Nature Structural Biology. 4: 456-62. PMID 9187653 DOI: 10.1038/nsb0697-456  1
1997 Barlow JN, Zhang Z, John P, Baldwin JE, Schofield CJ. Inactivation of 1-aminocyclopropane-1-carboxylate oxidase involves oxidative modifications. Biochemistry. 36: 3563-9. PMID 9132007 DOI: 10.1021/bi962521y  1
1997 Sami M, Brown TJ, Roach PL, Schofield CJ, Baldwin JE. Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans. Febs Letters. 405: 191-4. PMID 9089289  0.84
1997 Barlow JN, Baldwin JE, Clifton IJ, Gibson E, Hensgens CM, Hajdu J, Hara T, Hassan A, John P, Lloyd MD, Roach PL, Prescott A, Robinson JK, Zhang ZH, Schofield CJ. Studies on non-haem ferrous-dependent oxygenases and oxidases. Biochemical Society Transactions. 25: 86-90. PMID 9056849  1
1996 Roach PL, Clifton IJ, Hensgens CM, Shibata N, Long AJ, Strange RW, Hasnain SS, Schofield CJ, Baldwin JE, Hajdu J. Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies. European Journal of Biochemistry / Febs. 242: 736-40. PMID 9022704  1
1996 Lawrence CC, Sobey WJ, Field RA, Baldwin JE, Schofield CJ. Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis. The Biochemical Journal. 313: 185-91. PMID 8546682  0.84
1995 Shiau CY, Byford MF, Baldwin JE, Schofield CJ. Molecular mechanism of the multifunctional enzyme L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) synthetase. Biochemical Society Transactions. 23: 629S. PMID 8654814  0.84
1995 Shiau CY, Baldwin JE, Byford MF, Sobey WJ, Schofield CJ. delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: the order of peptide bond formation and timing of the epimerisation reaction. Febs Letters. 358: 97-100. PMID 7821439  0.84
1995 Roach PL, Clifton IJ, Fülöp V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE. Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. Nature. 375: 700-4. PMID 7791906 DOI: 10.1038/375700a0  1
1995 Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P. Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli. The Biochemical Journal. 307: 77-85. PMID 7717997  0.84
1995 Roach PL, Schofield CJ, Baldwin JE, Clifton IJ, Hajdu J. Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans. Protein Science : a Publication of the Protein Society. 4: 1007-9. PMID 7663335 DOI: 10.1002/pro.5560040521  1
1995 Shiau CY, Baldwin JE, Byford MF, Schofield CJ. Delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: isolation of L-cysteinyl-D-valine, a 'shunt' product, and implications for the order of peptide bond formation. Febs Letters. 373: 303-6. PMID 7589488  0.84
1994 Baldwin JE, Shiau CY, Byford MF, Schofield CJ. Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products. The Biochemical Journal. 301: 367-72. PMID 8042979  0.84
1994 Fujishima Y, Nordlund P, Pelosi G, Schofield CJ, Cole SJ, Baldwin JE, Hajdu J. Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium. Journal of Molecular Biology. 242: 712-4. PMID 7932729  0.84
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