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Christoph Loenarz, Ph.D. - Publications

Affiliations: 
2010-2015 Chemistry University of Oxford, Oxford, United Kingdom 
 2015- Chemistry University of Nottingham, Nottingham, England, United Kingdom 
Area:
Organic synthesis, chemical biology
Website:
https://www.nottingham.ac.uk/chemistry/people/christophloenarz.aspx
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Lippl K, Boleininger A, McDonough MA, Abboud MI, Tarhonskaya H, Chowdhury R, Loenarz C, Schofield CJ. Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal . Hypoxia (Auckland, N.Z.). 6: 57-71. PMID 30519597 DOI: 10.2147/Hp.S174655  0.72
2018 Thinnes CC, Lohans CT, Abboud MI, Yeh TL, Tumber A, Nowak RP, Attwood M, Cockman ME, Oppermann U, Loenarz C, Schofield C. Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30427558 DOI: 10.1002/Chem.201804790  0.744
2018 Abboud M, Chowdhury R, Leung I, Lippl K, Loenarz C, Claridge TDW, Schofield C. Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain. Chembiochem : a European Journal of Chemical Biology. PMID 30144273 DOI: 10.1002/Cbic.201800246  0.704
2018 Sekirnik R, Wilkins SE, Bush J, Tarhonskaya H, Münzel M, Hussein A, Flashman E, Mohammed S, McDonough MA, Loenarz C, Schofield CJ. YcfDis a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase. Extremophiles : Life Under Extreme Conditions. PMID 29523972 DOI: 10.1007/S00792-018-1016-9  0.611
2015 Longbotham JE, Levy C, Johannissen LO, Tarhonskaya H, Jiang S, Loenarz C, Flashman E, Hay S, Schofield CJ, Scrutton NS. Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase. Biochemistry. 54: 6093-105. PMID 26368022 DOI: 10.1021/Acs.Biochem.5B00789  0.549
2015 Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA. Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. Structure (London, England : 1993). 23: 639-52. PMID 25728928 DOI: 10.1016/J.Str.2015.01.014  0.706
2014 Davydova E, Ho AY, Malecki J, Moen A, Enserink JM, Jakobsson ME, Loenarz C, Falnes PØ. Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). The Journal of Biological Chemistry. 289: 30499-510. PMID 25231979 DOI: 10.1074/Jbc.M114.601658  0.477
2014 Katz MJ, Acevedo JM, Loenarz C, Galagovsky D, Liu-Yi P, Pérez-Pepe M, Thalhammer A, Sekirnik R, Ge W, Melani M, Thomas MG, Simonetta S, Boccaccio GL, Schofield CJ, Cockman ME, et al. Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth. Proceedings of the National Academy of Sciences of the United States of America. 111: 4025-30. PMID 24550463 DOI: 10.1073/Pnas.1314485111  0.554
2014 Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proceedings of the National Academy of Sciences of the United States of America. 111: 4019-24. PMID 24550462 DOI: 10.1073/Pnas.1311750111  0.793
2014 Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, Yamamoto A, Coleman ML, Kessler BM, et al. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proceedings of the National Academy of Sciences of the United States of America. 111: 4031-6. PMID 24550447 DOI: 10.1073/Pnas.1314482111  0.698
2013 Mazzon M, Peters NE, Loenarz C, Krysztofinska EM, Ember SW, Ferguson BJ, Smith GL. A mechanism for induction of a hypoxic response by vaccinia virus. Proceedings of the National Academy of Sciences of the United States of America. 110: 12444-9. PMID 23836663 DOI: 10.1073/Pnas.1302140110  0.438
2012 Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, Hamed RB, Chowdhury R, Gong L, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature Chemical Biology. 8: 960-2. PMID 23103944 DOI: 10.1038/Nchembio.1093  0.746
2011 Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. The Journal of Biological Chemistry. 286: 41616-25. PMID 21914792 DOI: 10.1074/Jbc.M111.283689  0.746
2011 Kawamura A, Loenarz C, Schofield CJ. Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry. Cell Cycle (Georgetown, Tex.). 10: 2819-20. PMID 21857150 DOI: 10.4161/Cc.10.17.16745  0.554
2011 Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). Plos One. 6: e16210. PMID 21264265 DOI: 10.1371/Journal.Pone.0016210  0.614
2011 Rotili D, Altun M, Hamed RB, Loenarz C, Thalhammer A, Hopkinson RJ, Tian YM, Ratcliffe PJ, Mai A, Kessler BM, Schofield CJ. Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions. Chemical Communications (Cambridge, England). 47: 1488-90. PMID 21152646 DOI: 10.1039/C0Cc04457A  0.674
2011 Loenarz C, Coleman ML, Boleininger A, Schierwater B, Holland PW, Ratcliffe PJ, Schofield CJ. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. Embo Reports. 12: 63-70. PMID 21109780 DOI: 10.1038/Embor.2010.170  0.571
2011 Thalhammer A, Mecinović J, Loenarz C, Tumber A, Rose NR, Heightman TD, Schofield CJ. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. Organic & Biomolecular Chemistry. 9: 127-35. PMID 21076780 DOI: 10.1039/C0Ob00592D  0.674
2011 Loenarz C, Schofield CJ. Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends in Biochemical Sciences. 36: 7-18. PMID 20728359 DOI: 10.1016/J.Tibs.2010.07.002  0.643
2010 McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ. Structural studies on human 2-oxoglutarate dependent oxygenases. Current Opinion in Structural Biology. 20: 659-72. PMID 20888218 DOI: 10.1016/J.Sbi.2010.08.006  0.763
2010 Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ. Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorganic & Medicinal Chemistry Letters. 20: 6125-8. PMID 20822901 DOI: 10.1016/J.Bmcl.2010.08.032  0.712
2010 Illingworth CJ, Loenarz C, Schofield CJ, Domene C. Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha. Biochemistry. 49: 6936-44. PMID 20695530 DOI: 10.1021/Bi100358T  0.523
2010 Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA. Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. Febs Letters. 584: 825-30. PMID 20067792 DOI: 10.1016/J.Febslet.2009.12.055  0.658
2010 Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Human Molecular Genetics. 19: 217-22. PMID 19843542 DOI: 10.1093/Hmg/Ddp480  0.669
2009 Mecinović J, Loenarz C, Chowdhury R, Schofield CJ. 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2. Bioorganic & Medicinal Chemistry Letters. 19: 6192-5. PMID 19775891 DOI: 10.1016/J.Bmcl.2009.09.005  0.665
2009 Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure (London, England : 1993). 17: 981-9. PMID 19604478 DOI: 10.1016/J.Str.2009.06.002  0.753
2009 Loenarz C, Schofield CJ. Oxygenase catalyzed 5-methylcytosine hydroxylation. Chemistry & Biology. 16: 580-3. PMID 19549596 DOI: 10.1016/J.Chembiol.2009.06.002  0.463
2009 Stubbs CJ, Loenarz C, Mecinović J, Yeoh KK, Hindley N, Liénard BM, Sobott F, Schofield CJ, Flashman E. Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure. Journal of Medicinal Chemistry. 52: 2799-805. PMID 19364117 DOI: 10.1021/Jm900285R  0.494
2009 Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ. Evidence for a stereoelectronic effect in human oxygen sensing. Angewandte Chemie (International Ed. in English). 48: 1784-7. PMID 19180614 DOI: 10.1002/Anie.200805427  0.688
2008 Lienard BM, Conejo-García A, Stolze I, Loenarz C, Oldham NJ, Ratcliffe PJ, Schofield CJ. Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases. Chemical Communications (Cambridge, England). 6393-5. PMID 19048166 DOI: 10.1039/B814440K  0.525
2008 Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. The Biochemical Journal. 416: 387-94. PMID 18713068 DOI: 10.1042/Bj20081238  0.686
2008 Burgess-Brown NA, Sharma S, Sobott F, Loenarz C, Oppermann U, Gileadi O. Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. Protein Expression and Purification. 59: 94-102. PMID 18289875 DOI: 10.1016/J.Pep.2008.01.008  0.322
2008 Loenarz C, Schofield CJ. Expanding chemical biology of 2-oxoglutarate oxygenases. Nature Chemical Biology. 4: 152-6. PMID 18277970 DOI: 10.1038/Nchembio0308-152  0.512
2008 Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ. Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. The Journal of Biological Chemistry. 283: 3808-15. PMID 18063574 DOI: 10.1074/Jbc.M707411200  0.744
2008 Loenarz C, Chowdhury R, Schofield CJ, Flashman E. Oxygenases for oxygen sensing Pure and Applied Chemistry. 80: 1837-1847. DOI: 10.1351/Pac200880081837  0.702
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