| Year |
Citation |
Score |
| 2023 |
Chen Y, Zhai N, Zhu Y, Yue P, Verma N, Brotherton-Pleiss C, Fu W, Nakamura K, Chen W, Kawakami J, Murali R, Tius MA, Lopez-Tapia F, Turkson J. Azetidine ring, salicylic acid, and salicylic acid bioisosteres as determinants of the binding characteristics of novel potent compounds to Stat3. Bioorganic & Medicinal Chemistry Letters. 129565. PMID 38008341 DOI: 10.1016/j.bmcl.2023.129565 |
0.584 |
|
| 2022 |
Zhu Y, Yue P, Dickinson CF, Yang JK, Datanagan K, Zhai N, Zhang Y, Miklossy G, Lopez-Tapia F, Tius MA, Turkson J. Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo. Cell Death & Disease. 13: 1022. PMID 36473850 DOI: 10.1038/s41419-022-05477-2 |
0.578 |
|
| 2022 |
Yue P, Zhu Y, Brotherton-Pleiss C, Fu W, Verma N, Chen J, Nakamura K, Chen W, Chen Y, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Kershaw KM, Celeridad M, Pan S, ... ... Turkson J, et al. Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo. Cancer Letters. 534: 215613. PMID 35276290 DOI: 10.1016/j.canlet.2022.215613 |
0.642 |
|
| 2022 |
Wang Y, Yang C, Sims MM, Sacher JR, Raje M, Deokar H, Yue P, Turkson J, Buolamwini JK, Pfeffer LM. SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo. Cancer Letters. 533: 215614. PMID 35245627 DOI: 10.1016/j.canlet.2022.215614 |
0.45 |
|
| 2020 |
Brotherton-Pleiss C, Yue P, Zhu Y, Nakamura K, Chen W, Fu W, Kubota C, Chen J, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Tius MA, Lopez-Tapia F, Turkson J. Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors. Journal of Medicinal Chemistry. PMID 33352047 DOI: 10.1021/acs.jmedchem.0c01705 |
0.638 |
|
| 2020 |
Conway ME, McDaniel JM, Graham JM, Guillen KP, Oliver PG, Parker SL, Yue P, Turkson J, Buchsbaum DJ, Welm BE, Myers RM, Varley KE. STAT3 and GR cooperate to drive gene expression and growth of basal-like triple-negative breast cancer. Cancer Research. PMID 32816914 DOI: 10.1158/0008-5472.Can-20-1379 |
0.361 |
|
| 2020 |
Dambal S, Alfaqih M, Sanders S, Maravilla E, Ramirez-Torres A, Galvan GC, Reis-Sobreiro M, Rotinen M, Driver LM, Brehove MS, Jovanovic Talisman T, Yoon J, You S, Turkson J, Chi JT, et al. 27-hydroxycholesterol impairs plasma membrane lipid raft signaling as evidenced by inhibition of IL6-JAK-STAT3 signaling in prostate cancer cells. Molecular Cancer Research : McR. PMID 32019810 DOI: 10.1158/1541-7786.Mcr-19-0974 |
0.325 |
|
| 2019 |
Neupane RP, Parrish SM, Neupane JB, Yoshida WY, Yip MLR, Turkson J, Harper MK, Head JD, Williams PG. Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge . Marine Drugs. 17. PMID 31331110 DOI: 10.3390/Md17070423 |
0.316 |
|
| 2019 |
Li C, Sarotti AM, Wu X, Yang B, Turkson J, Chen Y, Liu Q, Cao S. An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus sp. FT431. Molecules (Basel, Switzerland). 24. PMID 30621059 DOI: 10.3390/Molecules24010196 |
0.31 |
|
| 2018 |
Lopez-Tapia F, Brotherton-Pleiss C, Yue P, Murakami H, Costa Araujo AC, Reis Dos Santos B, Ichinotsubo E, Rabkin A, Shah R, Lantz M, Chen S, Tius MA, Turkson J. Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors. Acs Medicinal Chemistry Letters. 9: 250-255. PMID 29541369 DOI: 10.1021/Acsmedchemlett.7B00544 |
0.641 |
|
| 2017 |
Li CS, Sarotti AM, Huang P, Dang UT, Hurdle JG, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S. NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462. Scientific Reports. 7: 10424. PMID 28874704 DOI: 10.1038/S41598-017-10537-1 |
0.314 |
|
| 2017 |
Youn UJ, Sripisut T, Miklossy G, Turkson J, Laphookhieo S, Chang LC. Bioactive polyprenylated benzophenone derivatives from the fruits extracts of Garcinia xanthochymus. Bioorganic & Medicinal Chemistry Letters. PMID 28729053 DOI: 10.1016/j.bmcl.2017.06.073 |
0.474 |
|
| 2017 |
Hilliard T, Miklossy G, Chock C, Yue P, Williams P, Turkson J. 15∝-methoxypuupehenol induces antitumor effects in vitro and in vivo against human glioblastoma and breast cancer models. Molecular Cancer Therapeutics. PMID 28069875 DOI: 10.1158/1535-7163.MCT-16-0291 |
0.483 |
|
| 2015 |
Miklossy G, Youn UJ, YUe P, Zhang M, Chen CH, Hilliard TS, Paladino D, Li Y, Choi J, Sarkaria JN, Kawakami JK, Wongwiwatthananukit S, Chen Y, Sun D, Chang LC, ... Turkson J, et al. Hirsutinolide series inhibit Stat3 activity, alter GCN1, MAP1B, Hsp105, G6PD, vimentin, TrxR1, and importin α-2 expression, and induce antitumor effects against human glioma. Journal of Medicinal Chemistry. PMID 26331426 DOI: 10.1021/acs.jmedchem.5b00686 |
0.397 |
|
| 2015 |
Chelsky ZL, Yue P, Kondratyuk TP, Paladino D, Pezzuto JM, Cushman M, Turkson J. A Resveratrol Analogue Promotes ERKMAPK-Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells. Molecular Pharmacology. 88: 524-33. PMID 26138072 DOI: 10.1124/Mol.115.099093 |
0.422 |
|
| 2015 |
Yue P, Lopez-Tapia F, Paladino D, Li Y, Chen CH, Hilliard T, Chen Y, Tius MA, Turkson J. Hydroxamic acid and benzoic acid-based Stat3 inhibitors suppress human glioma and breast cancer phenotypes in vitro and in vivo. Cancer Research. PMID 26088127 DOI: 10.1158/0008-5472.Can-14-3558 |
0.665 |
|
| 2014 |
Youn UJ, Miklossy G, Chai X, Wongwiwatthananukit S, Toyama O, Songsak T, Turkson J, Chang LC. Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea. Fitoterapia. 93: 194-200. PMID 24370662 DOI: 10.1016/j.fitote.2013.12.013 |
0.436 |
|
| 2014 |
Hillion J, Belton AM, Shah SN, Turkson J, Jing N, Tweardy DJ, di Cello F, Huso DL, Resar LM. Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia. Leukemia & Lymphoma. 55: 1194-7. PMID 23829279 DOI: 10.3109/10428194.2013.821202 |
0.311 |
|
| 2012 |
Zhang X, Yue P, Page BD, Li T, Zhao W, Namanja AT, Paladino D, Zhao J, Chen Y, Gunning PT, Turkson J. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proceedings of the National Academy of Sciences of the United States of America. 109: 9623-8. PMID 22623533 DOI: 10.1073/Pnas.1121606109 |
0.493 |
|
| 2012 |
Page BD, Khoury H, Laister RC, Fletcher S, Vellozo M, Manzoli A, Yue P, Turkson J, Minden MD, Gunning PT. Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity. Journal of Medicinal Chemistry. 55: 1047-55. PMID 22148584 DOI: 10.1021/Jm200720N |
0.449 |
|
| 2011 |
Page BD, Fletcher S, Yue P, Li Z, Zhang X, Sharmeen S, Datti A, Wrana JL, Trudel S, Schimmer AD, Turkson J, Gunning PT. Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorganic & Medicinal Chemistry Letters. 21: 5605-9. PMID 21788134 DOI: 10.1016/J.Bmcl.2011.06.056 |
0.506 |
|
| 2011 |
Fletcher S, Page BD, Zhang X, Yue P, Li ZH, Sharmeen S, Singh J, Zhao W, Schimmer AD, Trudel S, Turkson J, Gunning PT. Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules. Chemmedchem. 6: 1459-70. PMID 21618433 DOI: 10.1002/Cmdc.201100194 |
0.538 |
|
| 2011 |
Shahani VM, Yue P, Haftchenary S, Zhao W, Lukkarila JL, Zhang X, Ball D, Nona C, Gunning PT, Turkson J. Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies. Acs Medicinal Chemistry Letters. 2: 79-84. PMID 21243039 DOI: 10.1021/Ml100224D |
0.512 |
|
| 2011 |
Shahani VM, Yue P, Fletcher S, Sharmeen S, Sukhai MA, Luu DP, Zhang X, Sun H, Zhao W, Schimmer AD, Turkson J, Gunning PT. Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein. Bioorganic & Medicinal Chemistry. 19: 1823-38. PMID 21216604 DOI: 10.1016/J.Bmc.2010.12.010 |
0.518 |
|
| 2010 |
Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, Wieckowski MR, Provero P, Pinton P, Poli V. A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging. 2: 823-42. PMID 21084727 |
0.313 |
|
| 2010 |
Zhao W, Jaganathan S, Turkson J. A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro. The Journal of Biological Chemistry. 285: 35855-65. PMID 20807764 DOI: 10.1074/jbc.M110.154088 |
0.376 |
|
| 2010 |
Jaganathan S, Yue P, Turkson J. Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src. The Journal of Pharmacology and Experimental Therapeutics. 333: 373-81. PMID 20100905 DOI: 10.1124/jpet.109.162669 |
0.313 |
|
| 2010 |
Zhang X, Yue P, Fletcher S, Zhao W, Gunning PT, Turkson J. A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes. Biochemical Pharmacology. 79: 1398-409. PMID 20067773 DOI: 10.1016/J.Bcp.2010.01.001 |
0.457 |
|
| 2009 |
Fletcher S, Singh J, Zhang X, Yue P, Page BD, Sharmeen S, Shahani VM, Zhao W, Schimmer AD, Turkson J, Gunning PT. Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities. Chembiochem : a European Journal of Chemical Biology. 10: 1959-64. PMID 19644994 DOI: 10.1002/Cbic.200900172 |
0.4 |
|
| 2009 |
Schiavone D, Dewilde S, Vallania F, Turkson J, Di Cunto F, Poli V. The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways. The Biochemical Journal. 421: 283-92. PMID 19397496 DOI: 10.1042/BJ20090061 |
0.333 |
|
| 2008 |
Hillion J, Dhara S, Sumter TF, Mukherjee M, Di Cello F, Belton A, Turkson J, Jaganathan S, Cheng L, Ye Z, Jove R, Aplan P, Lin YW, Wertzler K, Reeves R, et al. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies? Cancer Research. 68: 10121-7. PMID 19074878 DOI: 10.1158/0008-5472.Can-08-2121 |
0.318 |
|
| 2008 |
Fletcher S, Turkson J, Gunning PT. Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein. Chemmedchem. 3: 1159-68. PMID 18683176 DOI: 10.1002/Cmdc.200800123 |
0.429 |
|
| 2007 |
Siddiquee KA, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Schroeck C, Sebti SM, Jove R, Hamilton AD, Turkson J. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. Acs Chemical Biology. 2: 787-98. PMID 18154266 DOI: 10.1021/Cb7001973 |
0.381 |
|
| 2007 |
Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. 104: 7391-6. PMID 17463090 DOI: 10.1073/Pnas.0609757104 |
0.406 |
|
| 2007 |
Gunning PT, Katt WP, Glenn M, Siddiquee K, Siddique K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. Bioorganic & Medicinal Chemistry Letters. 17: 1875-8. PMID 17336521 DOI: 10.1016/J.Bmcl.2007.01.077 |
0.392 |
|
| 2006 |
Kotha A, Sekharam M, Cilenti L, Siddiquee K, Khaled A, Zervos AS, Carter B, Turkson J, Jove R. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Molecular Cancer Therapeutics. 5: 621-9. PMID 16546976 DOI: 10.1158/1535-7163.MCT-05-0268 |
0.358 |
|
| 2006 |
Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee JH, Beam CA, et al. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 11-9. PMID 16397018 DOI: 10.1158/1078-0432.Ccr-04-1752 |
0.409 |
|
| 2006 |
Anagnostopoulou A, Vultur A, Arulanandam R, Cao J, Turkson J, Jove R, Kim JS, Glenn M, Hamilton AD, Raptis L. Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer Letters. 242: 120-32. PMID 16377083 DOI: 10.1016/J.Canlet.2005.10.047 |
0.539 |
|
| 2005 |
Turkson J, Zhang S, Mora LB, Burns A, Sebti S, Jove R. Platinum compounds that inhibit constitutive stat3 signaling and induce cell cycle arrest and apoptosis of malignant cells Journal of Biological Chemistry. 280: 32979-32988. PMID 16046414 DOI: 10.1074/Jbc.M502694200 |
0.351 |
|
| 2005 |
Xu Q, Briggs J, Park S, Niu G, Kortylewski M, Zhang S, Gritsko T, Turkson J, Kay H, Semenza GL, Cheng JQ, Jove R, Yu H. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways Oncogene. 24: 5552-5560. PMID 16007214 DOI: 10.1038/Sj.Onc.1208719 |
0.345 |
|
| 2005 |
Nam S, Buettner R, Turkson J, Kim D, Cheng JQ, Muehlbeyer S, Hippe F, Vatter S, Merz KH, Eisenbrand G, Jove R. Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 5998-6003. PMID 15837920 DOI: 10.1073/pnas.0409467102 |
0.435 |
|
| 2005 |
Turkson J, Zhang S, Palmer J, Kay H, Stanko J, Mora LB, Sebti S, Yu H, Jove R. Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Molecular Cancer Therapeutics. 3: 1533-42. PMID 15634646 |
0.457 |
|
| 2004 |
Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M, Haura E, Sebti S, Hamilton AD, Jove R. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Molecular Cancer Therapeutics. 3: 261-9. PMID 15026546 |
0.488 |
|
| 2004 |
Vultur A, Cao J, Arulanandam R, Turkson J, Jove R, Greer P, Craig A, Elliott B, Raptis L. Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells. Oncogene. 23: 2600-16. PMID 15007380 DOI: 10.1038/Sj.Onc.1207378 |
0.435 |
|
| 2003 |
Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Research. 63: 1270-9. PMID 12649187 |
0.43 |
|
| 2002 |
Velichko S, Wagner TC, Turkson J, Jove R, Croze E. STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues. The Journal of Biological Chemistry. 277: 35635-41. PMID 12105218 DOI: 10.1074/Jbc.M204578200 |
0.338 |
|
| 2002 |
Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene. 21: 2000-8. PMID 11960372 DOI: 10.1038/Sj.Onc.1205260 |
0.334 |
|
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