Mikko Metsä-Ketelä - Publications

Affiliations: 
Turku University, Finland 

32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Oja T, San Martin Galindo P, Taguchi T, Manner S, Vuorela PM, Ichinose K, Metsä-Ketelä M, Fallarero A. Effective Antibiofilm Polyketides against Staphylococcus aureus from the Pyranonaphthoquinone Biosynthetic Pathways of Streptomyces Species. Antimicrobial Agents and Chemotherapy. 59: 6046-52. PMID 26195520 DOI: 10.1128/AAC.00991-15  0.6
2015 Guo F, Xiang S, Li L, Wang B, Rajasärkkä J, Gröndahl-Yli-Hannuksela K, Ai G, Metsä-Ketelä M, Yang K. Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection. Metabolic Engineering. 28: 134-42. PMID 25554073 DOI: 10.1016/j.ymben.2014.12.006  0.6
2014 Patrikainen P, Niiranen L, Thapa K, Paananen P, Tähtinen P, Mäntsälä P, Niemi J, Metsä-Ketelä M. Structure-based engineering of angucyclinone 6-ketoreductases. Chemistry & Biology. 21: 1381-91. PMID 25200607 DOI: 10.1016/j.chembiol.2014.07.017  0.6
2014 Thapa K, Oja T, Metsä-Ketelä M. Molecular evolution of the bacterial pseudouridine-5'-phosphate glycosidase protein family. The Febs Journal. 281: 4439-49. PMID 25081867 DOI: 10.1111/febs.12950  0.6
2013 Ueberschaar N, Xu Z, Scherlach K, Metsä-Ketelä M, Bretschneider T, Dahse HM, Görls H, Hertweck C. Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities. Journal of the American Chemical Society. 135: 17408-16. PMID 24143864 DOI: 10.1021/ja4080024  0.6
2013 Blauenburg B, Oja T, Klika KD, Metsä-Ketelä M. Chemoenzymatic synthesis of novel C-ribosylated naphthoquinones. Acs Chemical Biology. 8: 2377-82. PMID 24015959 DOI: 10.1021/cb400384c  0.6
2013 Metsä-Ketelä M, Oja T, Taguchi T, Okamoto S, Ichinose K. Biosynthesis of pyranonaphthoquinone polyketides reveals diverse strategies for enzymatic carbon-carbon bond formation. Current Opinion in Chemical Biology. 17: 562-70. PMID 23886982 DOI: 10.1016/j.cbpa.2013.06.032  0.6
2013 Paananen P, Patrikainen P, Kallio P, Mäntsälä P, Niemi J, Niiranen L, Metsä-Ketelä M. Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis. Biochemistry. 52: 5304-14. PMID 23848284 DOI: 10.1021/bi400712q  0.6
2013 Kallio P, Patrikainen P, Belogurov GA, Mäntsälä P, Yang K, Niemi J, Metsä-Ketelä M. Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE. Biochemistry. 52: 4507-16. PMID 23731237 DOI: 10.1021/bi400381s  0.6
2013 Taguchi T, Yabe M, Odaki H, Shinozaki M, Metsä-Ketelä M, Arai T, Okamoto S, Ichinose K. Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related Streptomyces antibiotics. Chemistry & Biology. 20: 510-20. PMID 23601640 DOI: 10.1016/j.chembiol.2013.03.007  0.6
2013 Oja T, Niiranen L, Sandalova T, Klika KD, Niemi J, Mäntsälä P, Schneider G, Metsä-Ketelä M. Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America. 110: 1291-6. PMID 23297194 DOI: 10.1073/pnas.1207407110  0.6
2012 Patrikainen P, Kallio P, Fan K, Klika KD, Shaaban KA, Mäntsälä P, Rohr J, Yang K, Niemi J, Metsä-Ketelä M. Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities. Chemistry & Biology. 19: 647-55. PMID 22633416 DOI: 10.1016/j.chembiol.2012.04.010  0.6
2012 Siitonen V, Blauenburg B, Kallio P, Mäntsälä P, Metsä-Ketelä M. Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis. Chemistry & Biology. 19: 638-46. PMID 22633415 DOI: 10.1016/j.chembiol.2012.04.009  0.6
2012 Oja T, Klika KD, Appassamy L, Sinkkonen J, Mäntsälä P, Niemi J, Metsä-Ketelä M. Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage. Proceedings of the National Academy of Sciences of the United States of America. 109: 6024-9. PMID 22474343 DOI: 10.1073/pnas.1201530109  0.6
2012 Grocholski T, Oja T, Humphrey L, Mäntsälä P, Niemi J, Metsä-Ketelä M. Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis. Journal of Bacteriology. 194: 2829-36. PMID 22467789 DOI: 10.1128/JB.00228-12  0.6
2012 Siitonen V, Claesson M, Patrikainen P, Aromaa M, Mäntsälä P, Schneider G, Metsä-Ketelä M. Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin. Chembiochem : a European Journal of Chemical Biology. 13: 120-8. PMID 22120896 DOI: 10.1002/cbic.201100637  0.6
2012 Tähtinen P, Oja T, Dreiack N, Mäntsälä P, Niemi J, Metsä-Ketelä M, Klika KD. Epimers vs. inverse epimers: The C-1 configuration in alnumycin A1 Rsc Advances. 2: 5098-5100. DOI: 10.1039/c2ra20537h  0.6
2012 Oja T, Tähtinen P, Dreiack N, Mäntsälä P, Niemi J, Metsä-Ketelä M, Klika KD. Alnumycins A2 and A3: New inverse-epimeric pairs stereoisomeric to alnumycin A1 Tetrahedron Asymmetry. 23: 670-682. DOI: 10.1016/j.tetasy.2012.05.001  0.6
2012 Klika KD, Tähtinen P, Mäntsälä P, Niemi J, Metsä-Ketelä M. The potential of VCD to resolve the epimer vs. inverse epimer quandary Computational and Theoretical Chemistry. 992: 156-163. DOI: 10.1016/j.comptc.2012.05.031  0.6
2011 Kallio P, Patrikainen P, Suomela JP, Mäntsälä P, Metsä-Ketelä M, Niemi J. Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis. Biochemistry. 50: 5535-43. PMID 21595438 DOI: 10.1021/bi200600k  0.6
2009 Xu Z, Metsä-Ketelä M, Hertweck C. Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives. Journal of Biotechnology. 140: 107-13. PMID 19047004 DOI: 10.1016/j.jbiotec.2008.10.013  0.6
2008 Oja T, Palmu K, Lehmussola H, Leppäranta O, Hännikäinen K, Niemi J, Mäntsälä P, Metsä-Ketelä M. Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis. Chemistry & Biology. 15: 1046-57. PMID 18940666 DOI: 10.1016/j.chembiol.2008.07.022  0.6
2008 Kallio P, Liu Z, Mäntsälä P, Niemi J, Metsä-Ketelä M. Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C. Chemistry & Biology. 15: 157-66. PMID 18291320 DOI: 10.1016/j.chembiol.2007.12.011  0.6
2008 Kallio P, Liu Z, Mäntsälä P, Niemi J, Metsä-Ketelä M. A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation. Journal of Molecular Biology. 375: 1212-21. PMID 18076902 DOI: 10.1016/j.jmb.2007.11.044  0.6
2008 Metsä-Ketelä M, Niemi J, Mäntsälä P, Schneider G. Anthracycline biosynthesis: Genes, enzymes and mechanisms Topics in Current Chemistry. 282: 101-140. DOI: 10.1007/128-2007-14  0.6
2008 Niemi J, Metsä-Ketelä M, Schneider G, Mäntsälä P. Biosynthetic anthracycline variants Topics in Current Chemistry. 282: 75-99. DOI: 10.1007/128-2007-13  0.6
2007 Koskiniemi H, Metsä-Ketelä M, Dobritzsch D, Kallio P, Korhonen H, Mäntsälä P, Schneider G, Niemi J. Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis. Journal of Molecular Biology. 372: 633-48. PMID 17669423 DOI: 10.1016/j.jmb.2007.06.087  0.6
2007 Palmu K, Ishida K, Mäntsälä P, Hertweck C, Metsä-Ketelä M. Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways. Chembiochem : a European Journal of Chemical Biology. 8: 1577-84. PMID 17654627 DOI: 10.1002/cbic.200700140  0.6
2004 Metsä-Ketelä M, Ylihonko K, Mäntsälä P. Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64. The Journal of Antibiotics. 57: 502-10. PMID 15515887  0.6
2003 Metsä-Ketelä M, Palmu K, Kunnari T, Ylihonko K, Mäntsälä P. Engineering anthracycline biosynthesis toward angucyclines. Antimicrobial Agents and Chemotherapy. 47: 1291-6. PMID 12654660 DOI: 10.1128/AAC.47.4.1291-1296.2003  0.6
2002 Metsä-Ketelä M, Halo L, Munukka E, Hakala J, Mäntsälä P, Ylihonko K. Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species. Applied and Environmental Microbiology. 68: 4472-9. PMID 12200302 DOI: 10.1128/AEM.68.9.4472-4479.2002  0.6
1999 Metsä-Ketelä M, Salo V, Halo L, Hautala A, Hakala J, Mäntsälä P, Ylihonko K. An efficient approach for screening minimal PKS genes from Streptomyces. Fems Microbiology Letters. 180: 1-6. PMID 10547437 DOI: 10.1016/S0378-1097(99)00453-X  0.6
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