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Drew James Adams - Publications

Affiliations: 
2009 Harvard University, Cambridge, MA, United States 
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chen YF, Shen Y, Yan DF, Ghazala M, Scemama de Gialluly MA, Srinivasan R, Farrar AN, Friedrich RM, Adams DJ. Electrophile Determines Cellular Phenotypes among XPO1-Targeting Small Molecules. Journal of Medicinal Chemistry. PMID 39005064 DOI: 10.1021/acs.jmedchem.4c00754  0.323
2024 Dorel R, Sun D, Carruthers N, Castanedo GM, Ung PM, Factor DC, Li T, Baumann H, Janota D, Pang J, Salphati L, Meklemburg R, Korman AJ, Harper HE, Stubblefield S, ... ... Adams DJ, et al. Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation. Journal of Medicinal Chemistry. PMID 38470227 DOI: 10.1021/acs.jmedchem.3c02396  0.321
2022 Caprariello AV, Adams DJ. The landscape of targets and lead molecules for remyelination. Nature Chemical Biology. 18: 925-933. PMID 35995862 DOI: 10.1038/s41589-022-01115-2  0.44
2022 Sax JL, Hershman SN, Hubler Z, Allimuthu D, Elitt MS, Bederman I, Adams DJ. Enhancers of Human and Rodent Oligodendrocyte Formation Predominantly Induce Cholesterol Precursor Accumulation. Acs Chemical Biology. PMID 35833657 DOI: 10.1021/acschembio.2c00330  0.769
2021 Pleshinger MJ, Friedrich RM, Hubler Z, Rivera-León AM, Gao F, Yan D, Sax JL, Srinivasan R, Bederman I, Shick HE, Tesar PJ, Adams DJ. Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation. Rsc Chemical Biology. 3: 56-68. PMID 35128409 DOI: 10.1039/d1cb00145k  0.489
2021 Sax JL, Hubler Z, Allimuthu D, Adams DJ. Screening Reveals Sterol Derivatives with Pro-Differentiation, Pro-Survival, or Potent Cytotoxic Effects on Oligodendrocyte Progenitor Cells. Acs Chemical Biology. PMID 34232635 DOI: 10.1021/acschembio.1c00461  0.771
2021 Hubler Z, Friedrich RM, Sax JL, Allimuthu D, Gao F, Rivera-León AM, Pleshinger MJ, Bederman I, Adams DJ. Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation. Cell Chemical Biology. PMID 33636107 DOI: 10.1016/j.chembiol.2021.01.025  0.772
2020 Factor DC, Barbeau AM, Allan KC, Hu LR, Madhavan M, Hoang AT, Hazel KEA, Hall PA, Nisraiyya S, Najm FJ, Miller TE, Nevin ZS, Karl RT, Lima BR, Song Y, ... ... Adams DJ, et al. Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS. Cell. PMID 32246942 DOI: 10.1016/J.Cell.2020.03.002  0.386
2019 Ogino M, Fedorov Y, Adams DJ, Okada K, Ito N, Sugiyama M, Ogino T. Vesiculopolins, a New Class of Anti-Vesiculoviral Compounds, Inhibit Transcription Initiation of Vesiculoviruses. Viruses. 11. PMID 31540123 DOI: 10.3390/V11090856  0.384
2019 Bayles I, Krajewska M, Pontius WD, Saiakhova A, Morrow JJ, Bartels C, Lu J, Faber ZJ, Fedorov Y, Hong ES, Karnuta JM, Rubin B, Adams DJ, George RE, Scacheri PC. Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma. The Journal of Clinical Investigation. PMID 31498151 DOI: 10.1172/Jci127718  0.387
2019 Allimuthu D, Hubler Z, Najm FJ, Tang H, Bederman I, Seibel W, Tesar PJ, Adams DJ. Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP. Cell Chemical Biology. PMID 30773481 DOI: 10.1016/J.Chembiol.2019.01.004  0.777
2019 Belur Nagaraj A, Joseph P, Ponting E, Fedorov Y, Singh S, Cole A, Lee W, Yoon E, Baccarini A, Scacheri P, Buckanovich R, Adams DJ, Drapkin R, Brown BD, DiFeo A. A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs. Stem Cell Reports. 12: 122-134. PMID 30629937 DOI: 10.1016/J.Stemcr.2018.12.002  0.301
2019 Visconte V, Adema V, Tiwari AD, Kerr CM, Awada H, Przychodzen B, Noe A, Toth R, Snider C, Parker Y, Fedorov Y, Adams D, Carraway HE, Advani AS, Kelly KR, et al. Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia Blood. 134: 564-564. DOI: 10.1182/Blood-2019-129189  0.357
2019 Kongkiatkamon S, Tiwari A, Adema V, Kerr CM, Przychodzen B, Awada H, Durrani J, Parker Y, Adams D, Fedorov Y, Carraway HE, Yang C, Sekeres MA, Lindner DJ, Phillips JG, et al. Therapeutic Applications of a Unique Calcium Channel Blocker to Target SF3B1 MDS Blood. 134: 881-881. DOI: 10.1182/Blood-2019-128671  0.383
2018 Elitt MS, Shick HE, Madhavan M, Allan KC, Clayton BLL, Weng C, Miller TE, Factor DC, Barbar L, Nawash BS, Nevin ZS, Lager AM, Li Y, Jin F, Adams DJ, et al. Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease. Stem Cell Reports. PMID 30146490 DOI: 10.1016/J.Stemcr.2018.07.015  0.445
2018 Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, ... ... Adams DJ, et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature. PMID 30046109 DOI: 10.1038/S41586-018-0360-3  0.77
2018 Zhang L, Fedorov Y, Adams D, Lin F. Identification of complement inhibitory activities of two chemotherapeutic agents using a high-throughput cell imaging-based screening assay. Molecular Immunology. 101: 86-91. PMID 29909366 DOI: 10.1016/J.Molimm.2018.06.009  0.445
2018 Visconte V, Przychodzen BP, Adema V, Hirsch CM, Noe A, Toth R, Snider C, Awada H, Graham AC, Parker Y, Fedorov Y, Adams D, Carraway HE, Advani AS, Radivoyevitch T, et al. Development of a Novel Class of Agents Targeting the RNA-Splicing Machinery in Myeloid Malignancies Blood. 132: 211-211. DOI: 10.1182/Blood-2018-99-116411  0.399
2018 Nguyen MT, Yan Y, Fedorvo Y, Pink J, Adams D, Gerson S. Abstract 1663: Identification and characterization of a small-molecule inhibitor of the human uracil-DNA glycosylase for use in combination with DNA damage-based anticancer therapies Cancer Research. 78: 1663-1663. DOI: 10.1158/1538-7445.Am2018-1663  0.416
2018 Lin F, Zhang L, Fedorov Y, Adams DJ. Identification of new complement inhibitors using a cell imaging-based, high-throughput screening assay Molecular Immunology. 102: 184. DOI: 10.1016/J.Molimm.2018.06.145  0.376
2017 Singleton KR, Crawford L, Tsui E, Manchester HE, Maertens O, Liu X, Liberti MV, Magpusao AN, Stein EM, Tingley JP, Frederick DT, Boland GM, Flaherty KT, McCall SJ, Krepler C, ... ... Adams DJ, et al. Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. Cell Reports. 21: 2796-2812. PMID 29212027 DOI: 10.1016/J.Celrep.2017.11.022  0.32
2017 Gorelenkova Miller O, Cole KS, Emerson CC, Allimuthu D, Golczak M, Stewart PL, Weerapana E, Adams DJ, Mieyal JJ. Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor. Plos One. 12: e0187991. PMID 29155853 DOI: 10.1371/Journal.Pone.0187991  0.728
2017 Allimuthu D, Adams DJ. 2-Chloropropionamide as a low-reactivity electrophile for irreversible small-molecule probe identification. Acs Chemical Biology. PMID 28613814 DOI: 10.1021/Acschembio.7B00424  0.754
2015 Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nature Chemical Biology. PMID 26656090 DOI: 10.1038/Nchembio.1986  0.412
2015 Abazeed M, Yard B, Adams D, Tamayo P, Hearn J, Chie EK, Schreiber S, Meyerson M, Peacock C, Hammerman P. Abstract 3315: Functional genomic profiling of lung adenocarcinoma identifies BRAF mutations as novel therapeutic targets Cancer Research. 75: 3315-3315. DOI: 10.1158/1538-7445.Am2015-3315  0.314
2015 Huynh M, Maire C, Abazeed M, Adams D, Pelton K, Pinnell N, Ramkissoon S, Korideck H, Van Hummelen P, Thorner A, Wen P, Ligon A, Schreiber S, Meyerson M, Ligon K, et al. Functional Profiling of a Glioblastoma (GBM) Patient-Derived Cell Line (PDCL) Panel Identifies Cell-Intrinsic Differential Radiation Response That Correlates With TP53 Mutations International Journal of Radiation Oncology*Biology*Physics. 93: E91-E92. DOI: 10.1016/J.Ijrobp.2015.07.779  0.301
2014 Adams DJ, Ito D, Rees MG, Seashore-Ludlow B, Puyang X, Ramos AH, Cheah JH, Clemons PA, Warmuth M, Zhu P, Shamji AF, Schreiber SL. NAMPT is the cellular target of STF-31-like small-molecule probes. Acs Chemical Biology. 9: 2247-54. PMID 25058389 DOI: 10.1021/Cb500347P  0.422
2014 Abazeed M, Adams D, Tamayo P, Meyerson M, Hammerman P, Schreiber S. Abstract 4259: The radiogenomic landscape of cancer Cancer Research. 74: 4259-4259. DOI: 10.1158/1538-7445.Am2014-4259  0.359
2014 Abazeed M, Xu C, Adams D, Tamayo P, Loeffler J, Suh J, Meyerson M, Wong K, Hammerman P. NRF2 Is a Novel Oncogene and Biomarker of Therapeutic Resistance in Non-Small Cell Lung Cancer International Journal of Radiation Oncology*Biology*Physics. 90: S104-S105. DOI: 10.1016/J.Ijrobp.2014.05.516  0.322
2013 Boskovic ZV, Hussain MM, Adams DJ, Dai M, Schreiber SL. Synthesis of piperlogs and analysis of their effects on cells. Tetrahedron. 69. PMID 24273350 DOI: 10.1016/J.Tet.2013.05.080  0.385
2013 Abazeed ME, Adams DJ, Hurov KE, Tamayo P, Creighton CJ, Sonkin D, Giacomelli AO, Du C, Fries DF, Wong KK, Mesirov JP, Loeffler JS, Schreiber SL, Hammerman PS, Meyerson M. Integrative radiogenomic profiling of squamous cell lung cancer. Cancer Research. 73: 6289-98. PMID 23980093 DOI: 10.1158/0008-5472.Can-13-1616  0.345
2013 Adams DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, Schreiber SL. Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death. Acs Chemical Biology. 8: 923-9. PMID 23477340 DOI: 10.1021/Cb300653V  0.406
2012 Adams DJ, Dai M, Pellegrino G, Wagner BK, Stern AM, Shamji AF, Schreiber SL. Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs. Proceedings of the National Academy of Sciences of the United States of America. 109: 15115-20. PMID 22949699 DOI: 10.1073/Pnas.1212802109  0.398
2012 Yuan Y, Wang Q, Paulk J, Kubicek S, Kemp MM, Adams DJ, Shamji AF, Wagner BK, Schreiber SL. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. Acs Chemical Biology. 7: 1152-7. PMID 22536950 DOI: 10.1021/Cb300139Y  0.396
2012 Evans DA, Adams DJ, Kwan EE. Progress toward the syntheses of (+)-GB 13, (+)-himgaline, and himandridine. new insights into intramolecular imine/enamine aldol cyclizations. Journal of the American Chemical Society. 134: 8162-70. PMID 22533781 DOI: 10.1021/Ja3001776  0.597
2007 Evans DA, Adams DJ. Total synthesis of (+)-galbulimima alkaloid 13 and (+)-himgaline. Journal of the American Chemical Society. 129: 1048-9. PMID 17263383 DOI: 10.1021/Ja0684996  0.39
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