Brian O. Bachmann, Ph.D. - Publications

Affiliations: 
2003- Chemistry Vanderbilt University, Nashville, TN 
Area:
Chemistry, Biosynthesis, Synthetic Biology
Website:
http://biosyntheticstudies.com/

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ellis BM, Fischer CN, Martin LB, Bachmann BO, McLean JA. Spatiochemically Profiling Microbial Interactions with Membrane Scaffolded Desorption Electrospray Ionization-Ion Mobility- Imaging Mass Spectrometry and Unsupervised Segmentation. Analytical Chemistry. PMID 31600444 DOI: 10.1021/acs.analchem.9b02992  0.36
2018 Starbird CA, Perry NA, Chen Q, Berndt S, Yamakawa I, Loukachevitch LV, Limbrick EM, Bachmann BO, Iverson TM, McCulloch KM. The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains. Biochemistry. PMID 30525509 DOI: 10.1021/acs.biochem.8b00836  0.56
2016 Covington BC, McLean JA, Bachmann BO. Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites. Natural Product Reports. PMID 27604382 DOI: 10.1039/c6np00048g  0.36
2016 Chong KM, Leelatian N, Deguire SM, Brockman AA, Earl D, Ihrie RA, Irish JM, Bachmann BO, Sulikowski GA. The use of fluorescently-tagged apoptolidins in cellular uptake and response studies. The Journal of Antibiotics. PMID 26956792 DOI: 10.1038/ja.2016.22  1
2016 Tianero MD, Pierce E, Raghuraman S, Sardar D, McIntosh JA, Heemstra JR, Schonrock Z, Covington BC, Maschek JA, Cox JE, Bachmann BO, Olivera BM, Ruffner DE, Schmidt EW. Metabolic model for diversity-generating biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831074 DOI: 10.1073/pnas.1525438113  1
2015 Sartor L, Ibarra C, Al-Mestarihi A, Bachmann BO, Vey JL. Structure of DnmZ, a nitrososynthase in the Streptomyces peucetius anthracycline biosynthetic pathway. Acta Crystallographica. Section F, Structural Biology Communications. 71: 1205-14. PMID 26457508 DOI: 10.1107/S2053230X15014272  1
2015 Derewacz DK, Covington BC, McLean JA, Bachmann BO. Mapping Microbial Response Metabolomes for Induced Natural Product Discovery. Acs Chemical Biology. PMID 26039241 DOI: 10.1021/acschembio.5b00001  1
2015 Goodwin CR, Covington BC, Derewacz DK, McNees CR, Wikswo JP, McLean JA, Bachmann BO. Structuring Microbial Metabolic Responses to Multiplexed Stimuli via Self-Organizing Metabolomics Maps. Chemistry & Biology. 22: 661-70. PMID 25937311 DOI: 10.1016/j.chembiol.2015.03.020  1
2015 DeGuire SM, Earl DC, Du Y, Crews BA, Jacobs AT, Ustione A, Daniel C, Chong KM, Marnett LJ, Piston DW, Bachmann BO, Sulikowski GA. Fluorescent probes of the apoptolidins and their utility in cellular localization studies. Angewandte Chemie (International Ed. in English). 54: 961-4. PMID 25430909 DOI: 10.1002/anie.201408906  1
2014 Stow SM, Goodwin CR, Kliman M, Bachmann BO, McLean JA, Lybrand TP. Distance geometry protocol to generate conformations of natural products to structurally interpret ion mobility-mass spectrometry collision cross sections. The Journal of Physical Chemistry. B. 118: 13812-20. PMID 25360896 DOI: 10.1021/jp509398e  1
2014 Derewacz DK, McNees CR, Scalmani G, Covington CL, Shanmugam G, Marnett LJ, Polavarapu PL, Bachmann BO. Structure and Stereochemical Determination of Hypogeamicins from a Cave-Derived Actinomycete. Journal of Natural Products. PMID 25046128 DOI: 10.1021/np400742p  1
2014 Kramer GJ, Mohd A, Schwager SL, Masuyer G, Acharya KR, Sturrock ED, Bachmann BO. Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes. Acs Medicinal Chemistry Letters. 5: 346-51. PMID 24900839 DOI: 10.1021/ml4004588  1
2014 McCranie EK, Bachmann BO. Bioactive oligosaccharide natural products. Natural Product Reports. 31: 1026-42. PMID 24883430 DOI: 10.1039/c3np70128j  1
2014 Goodwin CR, Sherrod SD, Marasco CC, Bachmann BO, Schramm-Sapyta N, Wikswo JP, McLean JA. Phenotypic mapping of metabolic profiles using self-organizing maps of high-dimensional mass spectrometry data. Analytical Chemistry. 86: 6563-71. PMID 24856386 DOI: 10.1021/ac5010794  1
2014 Birmingham WR, Starbird CA, Panosian TD, Nannemann DP, Iverson TM, Bachmann BO. Bioretrosynthetic construction of a didanosine biosynthetic pathway. Nature Chemical Biology. 10: 392-9. PMID 24657930 DOI: 10.1038/nchembio.1494  1
2014 Bachmann BO, Van Lanen SG, Baltz RH. Microbial genome mining for accelerated natural products discovery: is a renaissance in the making? Journal of Industrial Microbiology & Biotechnology. 41: 175-84. PMID 24342967 DOI: 10.1007/s10295-013-1389-9  1
2014 Stow SM, Lareau NM, Hines KM, Mcnees CR, Goodwin CR, Bachmann BO, Mclean JA. Structural Separations for Natural Product Characterization by Ion Mobility-Mass Spectrometry: Fundamental Theory to Emerging Applications Natural Products Analysis: Instrumentation, Methods, and Applications. 397-431. DOI: 10.1002/9781118876015.ch11  1
2013 Al-Mestarihi A, Romo A, Liu HW, Bachmann BO. Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis. Journal of the American Chemical Society. 135: 11457-60. PMID 23885759 DOI: 10.1021/ja404987r  1
2013 Derewacz DK, Goodwin CR, McNees CR, McLean JA, Bachmann BO. Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism. Proceedings of the National Academy of Sciences of the United States of America. 110: 2336-41. PMID 23341601 DOI: 10.1073/pnas.1218524110  1
2012 Iverson TM, Panosian TD, Birmingham WR, Nannemann DP, Bachmann BO. Molecular differences between a mutase and a phosphatase: investigations of the activation step in Bacillus cereus phosphopentomutase. Biochemistry. 51: 1964-75. PMID 22329805 DOI: 10.1021/bi201761h  1
2012 Goodwin CR, Fenn LS, Derewacz DK, Bachmann BO, McLean JA. Structural mass spectrometry: rapid methods for separation and analysis of peptide natural products. Journal of Natural Products. 75: 48-53. PMID 22216918 DOI: 10.1021/np200457r  1
2011 Du Y, Derewacz DK, Deguire SM, Teske J, Ravel J, Sulikowski GA, Bachmann BO. Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40. Tetrahedron. 67: 6568-6575. PMID 21869849 DOI: 10.1016/j.tet.2011.05.106  1
2011 Nannemann DP, Birmingham WR, Scism RA, Bachmann BO. Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis. Future Medicinal Chemistry. 3: 809-19. PMID 21644826 DOI: 10.4155/fmc.11.48  1
2011 Panosian TD, Nannemann DP, Watkins GR, Phelan VV, McDonald WH, Wadzinski BE, Bachmann BO, Iverson TM. Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. The Journal of Biological Chemistry. 286: 8043-54. PMID 21193409 DOI: 10.1074/jbc.M110.201350  1
2010 Vey JL, Al-Mestarihi A, Hu Y, Funk MA, Bachmann BO, Iverson TM. Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis . Biochemistry. 49: 9306-17. PMID 20866105 DOI: 10.1021/bi101336u  1
2010 Panosian TD, Nannemann DP, Bachmann BO, Iverson TM. Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 811-4. PMID 20606280 DOI: 10.1107/S1744309110017549  1
2010 Akif M, Ntai I, Sturrock ED, Isaac RE, Bachmann BO, Acharya KR. Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster. Biochemical and Biophysical Research Communications. 398: 532-6. PMID 20599761 DOI: 10.1016/j.bbrc.2010.06.113  1
2010 Nannemann DP, Kaufmann KW, Meiler J, Bachmann BO. Design and directed evolution of a dideoxy purine nucleoside phosphorylase. Protein Engineering, Design & Selection : Peds. 23: 607-16. PMID 20525731 DOI: 10.1093/protein/gzq033  1
2010 Bachmann BO, McNees R, Melancon BJ, Ghidu VP, Clark R, Crews BC, Deguire SM, Marnett LJ, Sulikowski GA. Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry. Organic Letters. 12: 2944-7. PMID 20515014 DOI: 10.1021/ol1009398  1
2010 Bachmann BO. Biosynthesis: is it time to go retro? Nature Chemical Biology. 6: 390-3. PMID 20479744 DOI: 10.1038/nchembio.377  1
2010 Du Y, Gisselberg JE, Johnson JD, Lee PJ, Prigge ST, Bachmann BO. Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener. Applied and Environmental Microbiology. 76: 3959-66. PMID 20418430 DOI: 10.1128/AEM.00170-10  1
2010 Carter MD, Phelan VV, Sandlin RD, Bachmann BO, Wright DW. Lipophilic mediated assays for beta-hematin inhibitors. Combinatorial Chemistry & High Throughput Screening. 13: 285-92. PMID 20230372 DOI: 10.2174/138620710790980496  1
2010 Reniere ML, Ukpabi GN, Harry SR, Stec DF, Krull R, Wright DW, Bachmann BO, Murphy ME, Skaar EP. The IsdG-family of haem oxygenases degrades haem to a novel chromophore. Molecular Microbiology. 75: 1529-38. PMID 20180905 DOI: 10.1111/j.1365-2958.2010.07076.x  1
2010 Scism RA, Bachmann BO. Five-component cascade synthesis of nucleotide analogues in an engineered self-immobilized enzyme aggregate. Chembiochem : a European Journal of Chemical Biology. 11: 67-70. PMID 19918830 DOI: 10.1002/cbic.200900620  1
2009 Ghidu VP, Ntai I, Wang J, Jacobs AT, Marnett LJ, Bachmann BO, Sulikowski GA. Combined chemical and biosynthetic route to access a new apoptolidin congener. Organic Letters. 11: 3032-4. PMID 19552384 DOI: 10.1021/ol901045v  1
2009 Phelan VV, Du Y, McLean JA, Bachmann BO. Adenylation enzyme characterization using gamma -(18)O(4)-ATP pyrophosphate exchange. Chemistry & Biology. 16: 473-8. PMID 19477411 DOI: 10.1016/j.chembiol.2009.04.007  1
2009 Bachmann BO, Ravel J. Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data. Methods in Enzymology. 458: 181-217. PMID 19374984 DOI: 10.1016/S0076-6879(09)04808-3  1
2008 Hu Y, Al-Mestarihi A, Grimes CL, Kahne D, Bachmann BO. A unifying nitrososynthase involved in nitrosugar biosynthesis. Journal of the American Chemical Society. 130: 15756-7. PMID 18983146 DOI: 10.1021/ja8051415  1
2008 Hu Y, Phelan VV, Farnet CM, Zazopoulos E, Bachmann BO. Reassembly of anthramycin biosynthetic gene cluster by using recombinogenic cassettes. Chembiochem : a European Journal of Chemical Biology. 9: 1603-8. PMID 18512205 DOI: 10.1002/cbic.200800029  1
2008 Ntai I, Bachmann BO. Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26. Bioorganic & Medicinal Chemistry Letters. 18: 3068-71. PMID 18096385 DOI: 10.1016/j.bmcl.2007.11.130  1
2007 Scism RA, Stec DF, Bachmann BO. Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase. Organic Letters. 9: 4179-82. PMID 17854193 DOI: 10.1021/ol7016802  1
2007 Bachmann BO. Foundations for directed alkaloid biosynthesis. Chemistry & Biology. 14: 875-6. PMID 17719485 DOI: 10.1016/j.chembiol.2007.08.001  1
2007 Hu Y, Phelan V, Ntai I, Farnet CM, Zazopoulos E, Bachmann BO. Benzodiazepine biosynthesis in Streptomyces refuineus. Chemistry & Biology. 14: 691-701. PMID 17584616 DOI: 10.1016/j.chembiol.2007.05.009  1
2007 Hu Y, Phelan V, Ntai I, Farnet CM, Zazopoulos E, Bachmann BO. Benzodiazepine Biosynthesis in Streptomyces refuineus (DOI:10.1016/j.chembiol.2007.05.009) Chemistry and Biology. 14: 870. DOI: 10.1016/j.chembiol.2007.07.006  1
2006 Ntai I, Phelan VV, Bachmann BO. Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis. Chemical Communications (Cambridge, England). 4518-20. PMID 17283804 DOI: 10.1039/b611768f  1
2006 Sulikowski MM, Bachmann BO. Designing a curriculum that goes beyond a list of topics. Acs Chemical Biology. 1: 489-91. PMID 17168533 DOI: 10.1021/cb6003178  1
2006 Wilkinson B, Bachmann BO. Biocatalysis in pharmaceutical preparation and alteration. Current Opinion in Chemical Biology. 10: 169-76. PMID 16500136 DOI: 10.1016/j.cbpa.2006.02.006  1
2005 Bachmann BO. Decoding chemical structures from genomes. Nature Chemical Biology. 1: 244-5. PMID 16408048 DOI: 10.1038/nchembio1005-244  1
2005 Ntai I, Manier ML, Hachey DL, Bachmann BO. Biosynthetic origins of C-P bond containing tripeptide K-26. Organic Letters. 7: 2763-5. PMID 15957941 DOI: 10.1021/ol051091d  1
2005 McAlpine JB, Bachmann BO, Piraee M, Tremblay S, Alarco AM, Zazopoulos E, Farnet CM. Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example. Journal of Natural Products. 68: 493-6. PMID 15844935 DOI: 10.1021/np0401664  1
2003 Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotechnology. 21: 187-90. PMID 12536216 DOI: 10.1038/nbt784  1
2002 Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots. Proceedings of the National Academy of Sciences of the United States of America. 99: 14752-7. PMID 12409610 DOI: 10.1073/pnas.232361199  1
2002 Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS. The calicheamicin gene cluster and its iterative type I enediyne PKS. Science (New York, N.Y.). 297: 1173-6. PMID 12183629 DOI: 10.1126/science.1072105  1
2001 Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nature Structural Biology. 8: 684-9. PMID 11473258 DOI: 10.1038/90394  1
2001 Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI. Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities. Journal of the American Chemical Society. 123: 7388-98. PMID 11472170 DOI: 10.1021/ja004025+  1
2000 Bachmann BO, Townsend CA. Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus. Biochemistry. 39: 11187-93. PMID 10985764 DOI: 10.1021/bi000709i  1
1998 Bachmann BO, Li R, Townsend CA. beta-Lactam synthetase: a new biosynthetic enzyme. Proceedings of the National Academy of Sciences of the United States of America. 95: 9082-6. PMID 9689037 DOI: 10.1073/pnas.95.16.9082  1
1998 Zhou J, Gunsior M, Bachmann BO, Townsend CA, Solomon EI. Substrate binding to the α-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: Coupling mechanism of oxidative decarboxylation and hydroxylation [14] Journal of the American Chemical Society. 120: 13539-13540. DOI: 10.1021/ja983534x  1
1997 Buynak JD, Srinivasa Rao A, Ford GP, Carver C, Adam G, Geng B, Bachmann B, Shobassy S, Lackey S. 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase Journal of Medicinal Chemistry. 40: 3423-3433. PMID 9341917 DOI: 10.1021/jm970351x  1
1995 Buynak JD, Wu K, Bachmann B, Khasnis D, Hua L, Nguyen HK, Carver CL. Synthesis and biological activity of 7-alkylidenecephems Journal of Medicinal Chemistry. 38: 1022-1034. PMID 7699694  1
1995 Buynak JD, Geng B, Bachmann B, Ling Hua. The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins Bioorganic and Medicinal Chemistry Letters. 5: 1513-1518. DOI: 10.1016/0960-894X(95)00249-S  1
1994 Buynak JD, Khasnis D, Bachmann B, Wu K, Lamb G. Synthesis and mechanistic evaluation of 7-vinylidenecephem sulfones as β-lactamase inhibitors Journal of the American Chemical Society. 116: 10955-10965. DOI: 10.1021/ja00103a010  1
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