| Year |
Citation |
Score |
| 2020 |
Sabbah M, Mendes V, Vistal RG, Dias DM, Záhorszká M, Mikušová K, Korduláková J, Coyne AG, Blundell TL, Abell C. Fragment-based design of Mycobacterium tuberculosis InhA inhibitors. Journal of Medicinal Chemistry. PMID 32240584 DOI: 10.1021/acs.jmedchem.0c00007 |
0.6 |
|
| 2020 |
Meng ZJ, Liu J, Yu Z, Zhou H, Deng X, Abell C, Scherman OA. Viscoelastic Hydrogel Microfibres Exploiting Cucurbit[8]uril Host-guest Chemistry and Microfluidics. Acs Applied Materials & Interfaces. PMID 32176477 DOI: 10.1021/acsami.9b21240 |
0.32 |
|
| 2019 |
Trapero A, Pacitto A, Chan DS, Abell C, Blundell TL, Ascher DB, Coyne AG. Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH). Bioorganic & Medicinal Chemistry Letters. 126792. PMID 31757668 DOI: 10.1016/j.bmcl.2019.126792 |
0.6 |
|
| 2019 |
Whitehouse AJ, Libardo MDJ, Kasbekar M, Brear PD, Fischer G, Thomas CJ, Barry C, Boshoff HIM, Coyne AG, Abell C. Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode. Journal of Medicinal Chemistry. PMID 31517489 DOI: 10.1021/acs.jmedchem.9b01203 |
0.6 |
|
| 2019 |
Chan DS, Hess J, Shaw E, Spry C, Starley R, Dagostin C, Dias MV, Kale R, Mendes V, Blundell TL, Coyne AG, Abell C. Structural Insights into Phosphopantothenoylcysteine Synthetase by Native Ion Mobility-Mass Spectrometry. The Biochemical Journal. PMID 31488574 DOI: 10.1042/BCJ20190318 |
0.6 |
|
| 2019 |
Whitehouse A, Thomas SE, Brown KP, Fanourakis A, Chan D, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG. Development of inhibitors against Mycobacterium abscessus tRNA (m1G37) methyltransferase (TrmD) using fragment-based approaches. Journal of Medicinal Chemistry. PMID 31282680 DOI: 10.1021/acs.jmedchem.9b00809 |
0.6 |
|
| 2019 |
Thomas SE, Collins P, James RH, Mendes V, Charoensutthivarakul S, Radoux C, Abell C, Coyne AG, Floto RA, von Delft F, Blundell TL. Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 377: 20180422. PMID 31030650 DOI: 10.1098/rsta.2018.0422 |
0.6 |
|
| 2019 |
Bestgen B, Krimm I, Kufareva I, Kamal A, Seetoh WG, Abell C, Hartmann RW, Abagyan R, Cochet C, Le Borgne M, Engel M, Lomberget T. 2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 1: Identification of an allosteric binding site. Journal of Medicinal Chemistry. PMID 30689953 DOI: 10.1021/acs.jmedchem.8b01766 |
0.4 |
|
| 2018 |
Lan Y, Caciagli A, Guidetti G, Yu Z, Liu J, Johansen VE, Kamp M, Abell C, Vignolini S, Scherman OA, Eiser E. Unexpected stability of aqueous dispersions of raspberry-like colloids. Nature Communications. 9: 3614. PMID 30190497 DOI: 10.1038/s41467-018-05560-3 |
0.32 |
|
| 2018 |
Ren X, Yu Z, Wu Y, Liu J, Abell C, Scherman OA. Cucurbit[7]uril-based high-performance catalytic microreactors. Nanoscale. PMID 30051893 DOI: 10.1039/c8nr02900h |
0.32 |
|
| 2018 |
Trapero A, Pacitto A, Singh V, Sabbah M, Coyne AG, Mizrahi V, Blundell TL, Ascher DB, Abell C. A fragment-based approach to targeting inosine-5´-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 29547284 DOI: 10.1021/acs.jmedchem.7b01622 |
0.6 |
|
| 2018 |
Yu Z, Liu J, Tan CSY, Scherman OA, Abell C. Supramolecular Nested Microbeads as Building Blocks for Macroscopic Self-healing Scaffolds. Angewandte Chemie (International Ed. in English). PMID 29377541 DOI: 10.1002/anie.201711522 |
0.32 |
|
| 2017 |
Groombridge AS, Palma A, Parker RM, Abell C, Scherman OA. Aqueous interfacial gels assembled from small molecule supramolecular polymers. Chemical Science. 8: 1350-1355. PMID 29780448 DOI: 10.1039/c6sc04103e |
0.32 |
|
| 2017 |
Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP. Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach. Frontiers in Pharmacology. 8: 681. PMID 29018348 DOI: 10.3389/fphar.2017.00681 |
0.44 |
|
| 2017 |
Chan DS, Whitehouse AJ, Coyne AG, Abell C. Mass spectrometry for fragment screening. Essays in Biochemistry. PMID 28986384 DOI: 10.1042/EBC20170071 |
0.6 |
|
| 2017 |
Chan DS, Kavanagh MEE, McLean KJ, Munro AW, Matak-Vinkovic D, Coyne AG, Abell C. Effect of DMSO on Protein Structure and Interactions Assessed By Collision-induced Dissociation and Unfolding. Analytical Chemistry. PMID 28803470 DOI: 10.1021/acs.analchem.7b02329 |
0.6 |
|
| 2017 |
Wu Y, Shah DU, Liu C, Yu Z, Liu J, Ren X, Rowland MJ, Abell C, Ramage MH, Scherman OA. Bioinspired supramolecular fibers drawn from a multiphase self-assembled hydrogel. Proceedings of the National Academy of Sciences of the United States of America. PMID 28696304 DOI: 10.1073/pnas.1705380114 |
0.32 |
|
| 2017 |
Chan DS, Mendes V, Thomas SE, McConnell BN, Matak-Vinković D, Coyne AG, Blundell TL, Abell C. Fragment screening against the EthR-DNA interaction by native mass spectrometry. Angewandte Chemie (International Ed. in English). PMID 28513917 DOI: 10.1002/anie.201702888 |
0.6 |
|
| 2017 |
Liu J, Tan CS, Yu Z, Li N, Abell C, Scherman OA. Tough Supramolecular Polymer Networks with Extreme Stretchability and Fast Room-Temperature Self-Healing. Advanced Materials (Deerfield Beach, Fla.). PMID 28370560 DOI: 10.1002/adma.201605325 |
0.32 |
|
| 2017 |
Macaulay KM, Heath GA, Ciulli A, Murphy AM, Abell C, Carr JP, Smith AG. The biochemical properties of the two Arabidopsis thaliana isochorismate synthases. The Biochemical Journal. PMID 28356402 DOI: 10.1042/BCJ20161069 |
0.44 |
|
| 2017 |
Nikiforov PO, Blaszczyk M, Surade S, Boshoff HI, Sajid A, Delorme V, Deboosere N, Brodin P, Baulard AR, Barry Rd CE, Blundell TL, Abell C. Fragment-sized EthR inhibitors exhibit exceptionally strong ethionamide boosting effect in whole cell Mycobacterium tuberculosis assays. Acs Chemical Biology. PMID 28314097 DOI: 10.1021/acschembio.7b00091 |
0.44 |
|
| 2017 |
Shiu-Hin Chan D, Seetoh WG, McConnell BN, Matak-Vinković D, Thomas SE, Mendes V, Blaszczyk M, Coyne AG, Blundell TL, Abell C. Structural insights into the EthR-DNA interaction using native mass spectrometry. Chemical Communications (Cambridge, England). PMID 28287239 DOI: 10.1039/c7cc00804j |
0.6 |
|
| 2017 |
Kavanagh ME, Chenge J, Zoufir A, McLean KJ, Coyne AG, Bender A, Munro AW, Abell C. A fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1. Biochemistry. PMID 28169518 DOI: 10.1021/acs.biochem.6b00954 |
0.6 |
|
| 2017 |
Kavanagh ME, Gray JL, Gilbert SH, Coyne AG, McLean KJ, Davis HJ, Munro AW, Abell C. Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors. Chemmedchem. 12: 194-195. PMID 28112499 DOI: 10.1002/cmdc.201600619 |
0.6 |
|
| 2017 |
Liu J, Tan CS, Yu Z, Lan Y, Abell C, Scherman OA. Biomimetic Supramolecular Polymer Networks Exhibiting both Toughness and Self-Recovery. Advanced Materials (Deerfield Beach, Fla.). PMID 28092128 DOI: 10.1002/adma.201604951 |
0.32 |
|
| 2017 |
Liu J, Lan Y, Yu Z, Tan CS, Parker RM, Abell C, Scherman OA. Cucurbit[n]uril-Based Microcapsules Self-Assembled within Microfluidic Droplets: A Versatile Approach for Supramolecular Architectures and Materials. Accounts of Chemical Research. PMID 28075551 DOI: 10.1021/acs.accounts.6b00429 |
0.32 |
|
| 2016 |
Chenge JT, Le DV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW. Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. The Journal of Biological Chemistry. PMID 27932461 DOI: 10.1074/jbc.M116.748822 |
0.6 |
|
| 2016 |
Marchetti C, Chan DS, Coyne AG, Abell C. Fragment-based approaches to TB drugs. Parasitology. 1-12. PMID 27804891 DOI: 10.1017/S0031182016001876 |
0.6 |
|
| 2016 |
Moschetti T, Sharpe T, Fischer G, Marsh ME, Ng H, Morgan M, Scott D, Blundell TL, Venkitaraman A, Skidmore J, Abell C, Hyvönen M. Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51. Journal of Molecular Biology. PMID 27725183 DOI: 10.1016/j.jmb.2016.10.009 |
0.44 |
|
| 2016 |
Salmon AR, Parker RM, Groombridge AS, Maestro A, Coulston RJ, Hegemann J, Kierfeld J, Scherman OA, Abell C. Microcapsule Buckling Triggered by Compression-Induced Interfacial Phase Change. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 27700114 DOI: 10.1021/acs.langmuir.6b03011 |
0.32 |
|
| 2016 |
Best RJ, Lyczakowski JJ, Abalde-Cela S, Yu Z, Abell C, Smith AG. Label-free analysis and sorting of microalgae and cyanobacteria in microdroplets by intrinsic chlorophyll fluorescence for the identification of fast growing strains. Analytical Chemistry. PMID 27677315 DOI: 10.1021/acs.analchem.6b02364 |
0.44 |
|
| 2016 |
Parker RM, Frka-Petesic B, Guidetti G, Kamita G, Consani G, Abell C, Vignolini S. Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry. Acs Nano. PMID 27564644 DOI: 10.1021/acsnano.6b03355 |
1 |
|
| 2016 |
Kavanagh ME, Gray JL, Gilbert SH, Coyne AG, McLean KJ, Davis HJ, Munro AW, Abell C. Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors. Chemmedchem. PMID 27432475 DOI: 10.1002/cmdc.201600248 |
1 |
|
| 2016 |
Thomas JC, Cooper JM, Clayton NS, Wang C, White MA, Abell C, Owen D, Mott HR. Inhibition of Ral GTPases Using a Stapled Peptide Approach. The Journal of Biological Chemistry. PMID 27334922 DOI: 10.1074/jbc.M116.720243 |
1 |
|
| 2016 |
Kasbekar M, Fischer G, Mott BT, Yasgar A, Hyvönen M, Boshoff HI, Abell C, Barry CE, Thomas CJ. Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site. Proceedings of the National Academy of Sciences of the United States of America. PMID 27325754 DOI: 10.1073/pnas.1600630113 |
1 |
|
| 2016 |
Davis HJ, Kavanagh ME, Balan T, Abell C, Coyne AG. Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis. Bioorganic & Medicinal Chemistry Letters. PMID 27287372 DOI: 10.1016/j.bmcl.2016.05.073 |
1 |
|
| 2016 |
Chenge J, Kavanagh ME, Driscoll MD, McLean KJ, Young DB, Cortes T, Matak-Vinkovic D, Levy CW, Rigby SE, Leys D, Abell C, Munro AW. Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis. Scientific Reports. 6: 26628. PMID 27225995 DOI: 10.1038/srep26628 |
1 |
|
| 2016 |
Kavanagh ME, Coyne AG, McLean KJ, James GG, Levy CW, Marino LB, de Carvalho LP, Chan DS, Hudson SA, Surade S, Leys D, Munro AW, Abell C. Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. Journal of Medicinal Chemistry. 59: 3272-302. PMID 27002486 DOI: 10.1021/acs.jmedchem.6b00007 |
1 |
|
| 2016 |
Seetoh WG, Chan DS, Matak-Vinković D, Abell C. Mass Spectrometry Reveals Protein Kinase CK2 High-Order Oligomerization via the Circular and Linear Assembly. Acs Chemical Biology. 11: 1511-7. PMID 26999075 DOI: 10.1021/acschembio.6b00064 |
0.52 |
|
| 2016 |
Scott DE, Marsh M, Blundell TL, Abell C, Hyvönen M. Structure Activity Relationship of the Peptide Binding Motif Mediating the RAD51:BRCA2 Protein-Protein Interaction. Febs Letters. PMID 26992456 DOI: 10.1002/1873-3468.12139 |
1 |
|
| 2016 |
Yu ZY, Zheng Y, Parker RM, Lan Y, Wu Y, Coulston RJ, Zhang J, Scherman OA, Abell C. Microfluidic droplet facilitated hierarchical assembly for dual cargo loading and synergistic delivery. Acs Applied Materials & Interfaces. PMID 26982167 DOI: 10.1021/acsami.6b00661 |
1 |
|
| 2016 |
Salmon AR, Esteban R, Taylor RW, Hugall JT, Smith CA, Whyte G, Scherman OA, Aizpurua J, Abell C, Baumberg JJ. Monitoring Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS. Small (Weinheim An Der Bergstrasse, Germany). PMID 26865562 DOI: 10.1002/smll.201503513 |
1 |
|
| 2016 |
Nikiforov PO, Surade S, Blaszczyk M, Delorme V, Brodin P, Baulard AR, Blundell TL, Abell C. A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Organic & Biomolecular Chemistry. PMID 26806381 DOI: 10.1039/c5ob02630j |
1 |
|
| 2016 |
Chaikuad A, Lang S, Brennan PE, Temperini C, Fedorov O, Hollander J, Nachane R, Abell C, Müller S, Siegal G, Knapp S. Structure-based identification of inhibitory fragments targeting the p300/CBP-associated factor bromodomain. Journal of Medicinal Chemistry. PMID 26731131 DOI: 10.1021/acs.jmedchem.5b01719 |
1 |
|
| 2016 |
Marsh ME, Scott DE, Ehebauer MT, Abell C, Blundell TL, Hyvönen M. ATP half-sites in RadA and RAD51 recombinases bind nucleotides Febs Open Bio. 6: 372-385. DOI: 10.1002/2211-5463.12052 |
1 |
|
| 2015 |
Tan YS, Spring DR, Abell C, Verma CS. The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions. Journal of Chemical Theory and Computation. 11: 3199-3210. PMID 26575757 DOI: 10.1021/ct5010577 |
1 |
|
| 2015 |
Hung AW, Silvestre HL, Wen S, George GP, Boland J, Blundell TL, Ciulli A, Abell C. Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. Chemmedchem. PMID 26486566 DOI: 10.1002/cmdc.201500414 |
1 |
|
| 2015 |
Xu X, Tian F, Liu X, Parker RM, Lan Y, Wu Y, Yu Z, Scherman OA, Abell C. Supracolloidal Architectures Self-Assembled in Microdroplets. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26351242 DOI: 10.1002/chem.201503194 |
1 |
|
| 2015 |
Xu X, Appel EA, Liu X, Parker RM, Scherman OA, Abell C. Formation of Cucurbit[8]uril-Based Supramolecular Hydrogel Beads Using Droplet-Based Microfluidics. Biomacromolecules. 16: 2743-9. PMID 26256409 DOI: 10.1021/acs.biomac.5b01048 |
1 |
|
| 2015 |
Parker RM, Zhang J, Zheng Y, Coulston RJ, Smith CA, Salmon AR, Yu Z, Scherman OA, Abell C. Electrostatically Directed Self-Assembly of Ultrathin Supramolecular Polymer Microcapsules. Advanced Functional Materials. 25: 4091-4100. PMID 26213532 DOI: 10.1002/adfm.201501079 |
1 |
|
| 2015 |
Foster JA, Parker RM, Belenguer AM, Kishi N, Sutton S, Abell C, Nitschke JR. Differentially Addressable Cavities within Metal-organic Cage-cross-linked Polymeric Hydrogels. Journal of the American Chemical Society. PMID 26153733 DOI: 10.1021/jacs.5b05507 |
1 |
|
| 2015 |
Holvey RS, Valkov E, Neal D, Stewart M, Abell C. Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design. Chemmedchem. 10: 1232-9. PMID 25899172 DOI: 10.1002/cmdc.201500014 |
1 |
|
| 2015 |
Abalde-Cela S, Gould A, Liu X, Kazamia E, Smith AG, Abell C. High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform. Journal of the Royal Society, Interface / the Royal Society. 12. PMID 25878135 DOI: 10.1098/rsif.2015.0216 |
1 |
|
| 2015 |
Hu C, Zheng Y, Yu Z, Abell C, Scherman OA. Surface-immobilised micelles via cucurbit[8]uril-rotaxanes for solvent-induced burst release. Chemical Communications (Cambridge, England). 51: 4858-60. PMID 25697353 DOI: 10.1039/c5cc00121h |
1 |
|
| 2015 |
Mashalidis EH, Gittis AG, Tomczak A, Abell C, Barry CE, Garboczi DN. Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis. Protein Science : a Publication of the Protein Society. 24: 729-40. PMID 25644473 DOI: 10.1002/pro.2645 |
1 |
|
| 2015 |
Scott DE, Coyne AG, Venkitaraman A, Blundell TL, Abell C, Hyvönen M. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. Chemmedchem. 10: 296-303. PMID 25470112 DOI: 10.1002/cmdc.201402428 |
1 |
|
| 2015 |
Howard NI, Dias MV, Peyrot F, Chen L, Schmidt MF, Blundell TL, Abell C. Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis. Chemmedchem. 10: 116-33. PMID 25234229 DOI: 10.1002/cmdc.201402298 |
1 |
|
| 2015 |
Yu Z, Zhang J, Coulston RJ, Parker RM, Biedermann F, Liu X, Scherman OA, Abell C. Supramolecular hydrogel microcapsules via cucurbit[8]uril host-guest interactions with triggered and UV-controlled molecular permeability Chemical Science. 6: 4929-4933. DOI: 10.1039/c5sc01440a |
1 |
|
| 2015 |
Howard S, Abell C. Preface Rsc Drug Discovery Series. 2015: ix-x. |
1 |
|
| 2015 |
Abell C, Dagostin C. Different flavours of fragments Rsc Drug Discovery Series. 2015: 1-18. |
1 |
|
| 2014 |
Zheng Y, Yu Z, Parker RM, Wu Y, Abell C, Scherman OA. Interfacial assembly of dendritic microcapsules with host-guest chemistry. Nature Communications. 5: 5772. PMID 25511608 DOI: 10.1038/ncomms6772 |
1 |
|
| 2014 |
Ferguson FM, Dias DM, Rodrigues JP, Wienk H, Boelens R, Bonvin AM, Abell C, Ciulli A. Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking. Biochemistry. 53: 6706-16. PMID 25266743 DOI: 10.1021/bi500909d |
1 |
|
| 2014 |
Fischlechner M, Schaerli Y, Mohamed MF, Patil S, Abell C, Hollfelder F. Evolution of enzyme catalysts caged in biomimetic gel-shell beads. Nature Chemistry. 6: 791-6. PMID 25143214 DOI: 10.1038/nchem.1996 |
1 |
|
| 2014 |
Mageed SN, Cunningham F, Hung AW, Silvestre HL, Wen S, Blundell TL, Abell C, McConkey GA. Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy. Antimicrobial Agents and Chemotherapy. 58: 6345-53. PMID 25049241 DOI: 10.1128/AAC.02640-14 |
1 |
|
| 2014 |
Srinivasan R, Coyne AG, Abell C. Regioselective conversion of arenes to N-aryl-1,2,3-triazoles using C-H borylation. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 11680-4. PMID 25048717 DOI: 10.1002/chem.201403021 |
1 |
|
| 2014 |
Tan YS, Spring DR, Abell C, Verma C. The use of chlorobenzene as a probe molecule in molecular dynamics simulations. Journal of Chemical Information and Modeling. 54: 1821-7. PMID 24910248 DOI: 10.1021/ci500215x |
1 |
|
| 2014 |
Stephenson G, Parker RM, Lan Y, Yu Z, Scherman OA, Abell C. Supramolecular colloidosomes: fabrication, characterisation and triggered release of cargo. Chemical Communications (Cambridge, England). 50: 7048-51. PMID 24848874 DOI: 10.1039/c4cc01479k |
1 |
|
| 2014 |
Warner KD, Homan P, Weeks KM, Smith AG, Abell C, Ferré-D'Amaré AR. Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically. Chemistry & Biology. 21: 591-5. PMID 24768306 DOI: 10.1016/j.chembiol.2014.03.007 |
1 |
|
| 2014 |
Webb ME, Yorke BA, Kershaw T, Lovelock S, Lobley CM, Kilkenny ML, Smith AG, Blundell TL, Pearson AR, Abell C. Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase. Acta Crystallographica. Section D, Biological Crystallography. 70: 1166-72. PMID 24699660 DOI: 10.1107/S1399004713034275 |
1 |
|
| 2014 |
Hudson SA, Mashalidis EH, Bender A, McLean KJ, Munro AW, Abell C. Biofragments: an approach towards predicting protein function using biologically related fragments and its application to Mycobacterium tuberculosis CYP126. Chembiochem : a European Journal of Chemical Biology. 15: 549-55. PMID 24677424 DOI: 10.1002/cbic.201300697 |
1 |
|
| 2014 |
Ndieyira JW, Kappeler N, Logan S, Cooper MA, Abell C, McKendry RA, Aeppli G. Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum. Nature Nanotechnology. 9: 225-32. PMID 24584276 DOI: 10.1038/nnano.2014.33 |
1 |
|
| 2014 |
Nasiri HR, Bell NM, McLuckie KI, Husby J, Abell C, Neidle S, Balasubramanian S. Targeting a c-MYC G-quadruplex DNA with a fragment library. Chemical Communications (Cambridge, England). 50: 1704-7. PMID 24394582 DOI: 10.1039/c3cc48390h |
1 |
|
| 2014 |
Surade S, Ty N, Hengrung N, Lechartier B, Cole ST, Abell C, Blundell TL. A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR. The Biochemical Journal. 458: 387-94. PMID 24313835 DOI: 10.1042/BJ20131127 |
1 |
|
| 2014 |
Abalde-Cela S, Abell C, Alvarez-Puebla RA, Liz-Marzán LM. Real time dual-channel multiplex SERS ultradetection Journal of Physical Chemistry Letters. 5: 73-79. DOI: 10.1021/jz402419k |
1 |
|
| 2013 |
Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. Journal of Medicinal Chemistry. 56: 10183-7. PMID 24304323 DOI: 10.1021/jm401582c |
1 |
|
| 2013 |
Mashalidis EH, ?led? P, Lang S, Abell C. A three-stage biophysical screening cascade for fragment-based drug discovery. Nature Protocols. 8: 2309-24. PMID 24157549 DOI: 10.1038/nprot.2013.130 |
1 |
|
| 2013 |
Schmidt MF, Korb O, Abell C. MicroRNA-specific argonaute 2 protein inhibitors. Acs Chemical Biology. 8: 2122-6. PMID 23902134 DOI: 10.1021/cb400246k |
1 |
|
| 2013 |
Silvestre HL, Blundell TL, Abell C, Ciulli A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proceedings of the National Academy of Sciences of the United States of America. 110: 12984-9. PMID 23872845 DOI: 10.1073/pnas.1304045110 |
1 |
|
| 2013 |
Shim JU, Ranasinghe RT, Smith CA, Ibrahim SM, Hollfelder F, Huck WT, Klenerman D, Abell C. Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays. Acs Nano. 7: 5955-64. PMID 23805985 DOI: 10.1021/nn401661d |
1 |
|
| 2013 |
Hudson SA, Surade S, Coyne AG, McLean KJ, Leys D, Munro AW, Abell C. Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121. Chemmedchem. 8: 1451-6. PMID 23788280 DOI: 10.1002/cmdc.201300219 |
1 |
|
| 2013 |
Bai Y, Patil SN, Bowden SD, Poulter S, Pan J, Salmond GP, Welch M, Huck WT, Abell C. Intra-species bacterial quorum sensing studied at single cell level in a double droplet trapping system. International Journal of Molecular Sciences. 14: 10570-81. PMID 23698779 DOI: 10.3390/ijms140510570 |
1 |
|
| 2013 |
Duffell KM, Hudson SA, McLean KJ, Munro AW, Abell C, Matak-Vinkovi? D. Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions. Analytical Chemistry. 85: 5707-14. PMID 23675886 DOI: 10.1021/ac400236z |
1 |
|
| 2013 |
Smith CA, Li X, Mize TH, Sharpe TD, Graziani EI, Abell C, Huck WT. Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry. Analytical Chemistry. 85: 3812-6. PMID 23514243 DOI: 10.1021/ac400453t |
1 |
|
| 2013 |
Scott DE, Ehebauer MT, Pukala T, Marsh M, Blundell TL, Venkitaraman AR, Abell C, Hyvönen M. Using a fragment-based approach to target protein-protein interactions. Chembiochem : a European Journal of Chemical Biology. 14: 332-42. PMID 23344974 DOI: 10.1002/cbic.201200521 |
1 |
|
| 2013 |
Schmidt MF, Korb O, Howard NI, Dias MV, Blundell TL, Abell C. Discovery of Schaeffer's acid analogues as lead structures of mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach. Chemmedchem. 8: 54-8. PMID 23169689 DOI: 10.1002/cmdc.201200508 |
1 |
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| 2013 |
Shim JU, Ranasinghe RT, Hollfelder F, Huck WTS, Klenerman D, Abell C, Cooper J. Megahertz-generated femtoliter microfluidic droplets for single-molecule-counting immunoassay 17th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2013. 1: 669-671. |
1 |
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| 2012 |
Tan YS, ?led? P, Lang S, Stubbs CJ, Spring DR, Abell C, Best RB. Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1. Angewandte Chemie (International Ed. in English). 51: 10078-81. PMID 22961729 DOI: 10.1002/anie.201205676 |
1 |
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| 2012 |
Ballester PJ, Mangold M, Howard NI, Robinson RL, Abell C, Blumberger J, Mitchell JB. Hierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit identification. Journal of the Royal Society, Interface / the Royal Society. 9: 3196-207. PMID 22933186 DOI: 10.1098/rsif.2012.0569 |
1 |
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| 2012 |
Hudson SA, McLean KJ, Surade S, Yang YQ, Leys D, Ciulli A, Munro AW, Abell C. Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121. Angewandte Chemie (International Ed. in English). 51: 9311-6. PMID 22890978 DOI: 10.1002/anie.201202544 |
1 |
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| 2012 |
Abrahams GL, Kumar A, Savvi S, Hung AW, Wen S, Abell C, Barry CE, Sherman DR, Boshoff HI, Mizrahi V. Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. Chemistry & Biology. 19: 844-54. PMID 22840772 DOI: 10.1016/j.chembiol.2012.05.020 |
1 |
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| 2012 |
?led? P, Lang S, Stubbs CJ, Abell C. High-throughput interrogation of ligand binding mode using a fluorescence-based assay. Angewandte Chemie (International Ed. in English). 51: 7680-3. PMID 22730171 DOI: 10.1002/anie.201202660 |
1 |
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| 2012 |
Scott DE, Coyne AG, Hudson SA, Abell C. Fragment-based approaches in drug discovery and chemical biology. Biochemistry. 51: 4990-5003. PMID 22697260 DOI: 10.1021/bi3005126 |
1 |
|
| 2012 |
Ma S, Thiele J, Liu X, Bai Y, Abell C, Huck WT. Fabrication of microgel particles with complex shape via selective polymerization of aqueous two-phase systems. Small (Weinheim An Der Bergstrasse, Germany). 8: 2356-60. PMID 22648761 DOI: 10.1002/smll.201102715 |
1 |
|
| 2012 |
Hudson SA, McLean KJ, Munro AW, Abell C. Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets. Biochemical Society Transactions. 40: 573-9. PMID 22616869 DOI: 10.1042/BST20120062 |
1 |
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| 2012 |
Chen L, Cressina E, Dixon N, Erixon K, Agyei-Owusu K, Micklefield J, Smith AG, Abell C, Leeper FJ. Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues. Organic & Biomolecular Chemistry. 10: 5924-31. PMID 22514012 DOI: 10.1039/c2ob07116a |
1 |
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| 2012 |
Webb ME, Lobley CM, Soliman F, Kilkenny ML, Smith AG, Blundell TL, Abell C. Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 414-7. PMID 22505409 DOI: 10.1107/S1744309112009487 |
1 |
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| 2012 |
Zhang J, Coulston RJ, Jones ST, Geng J, Scherman OA, Abell C. One-step fabrication of supramolecular microcapsules from microfluidic droplets. Science (New York, N.Y.). 335: 690-4. PMID 22323815 DOI: 10.1126/science.1215416 |
1 |
|
| 2012 |
Horrocks MH, Li H, Shim JU, Ranasinghe RT, Clarke RW, Huck WT, Abell C, Klenerman D. Single molecule fluorescence under conditions of fast flow. Analytical Chemistry. 84: 179-85. PMID 22147688 DOI: 10.1021/ac202313d |
1 |
|
| 2012 |
Śledź P, Abell C, Ciulli A. Ligand-Observed NMR in Fragment-Based Approaches Nmr of Biomolecules: Towards Mechanistic Systems Biology. 264-280. DOI: 10.1002/9783527644506.ch15 |
1 |
|
| 2011 |
Mashalidis EH, Mukherjee T, Sledź P, Matak-Vinković D, Boshoff H, Abell C, Barry CE. Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity. Plos One. 6: e27643. PMID 22110704 DOI: 10.1371/journal.pone.0027643 |
1 |
|
| 2011 |
Pan J, Stephenson AL, Kazamia E, Huck WT, Dennis JS, Smith AG, Abell C. Quantitative tracking of the growth of individual algal cells in microdroplet compartments. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 1043-51. PMID 21863189 DOI: 10.1039/c1ib00033k |
1 |
|
| 2011 |
?led? P, Stubbs CJ, Lang S, Yang YQ, McKenzie GJ, Venkitaraman AR, Hyvönen M, Abell C. From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1. Angewandte Chemie (International Ed. in English). 50: 4003-6. PMID 21472932 DOI: 10.1002/anie.201008019 |
1 |
|
| 2011 |
Cressina E, Chen L, Moulin M, Leeper FJ, Abell C, Smith AG. Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches. Biochemical Society Transactions. 39: 652-7. PMID 21428956 DOI: 10.1042/BST0390652 |
1 |
|
| 2011 |
Dias MV, Snee WC, Bromfield KM, Payne RJ, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. The Biochemical Journal. 436: 729-39. PMID 21410435 DOI: 10.1042/BJ20110002 |
1 |
|
| 2011 |
Shim JU, Patil SN, Hodgkinson JT, Bowden SD, Spring DR, Welch M, Huck WT, Hollfelder F, Abell C. Controlling the contents of microdroplets by exploiting the permeability of PDMS. Lab On a Chip. 11: 1132-7. PMID 21298160 DOI: 10.1039/c0lc00615g |
1 |
|
| 2011 |
Huebner AM, Abell C, Huck WT, Baroud CN, Hollfelder F. Monitoring a reaction at submillisecond resolution in picoliter volumes. Analytical Chemistry. 83: 1462-8. PMID 21244017 DOI: 10.1021/ac103234a |
1 |
|
| 2011 |
Zhou D, Li Y, Hall EA, Abell C, Klenerman D. A chelating dendritic ligand capped quantum dot: preparation, surface passivation, bioconjugation and specific DNA detection. Nanoscale. 3: 201-11. PMID 21046040 DOI: 10.1039/c0nr00462f |
1 |
|
| 2011 |
Abalde-Cela S, Auguié B, Fischlechner M, Huck WTS, Alvarez-Puebla RA, Liz-Marzán LM, Abell C. Microdroplet fabrication of silver-agarose nanocomposite beads for SERS optical accumulation Soft Matter. 7: 1321-1325. DOI: 10.1039/c0sm00601g |
1 |
|
| 2011 |
Cressina E, Chen L, Abell C, Leeper FJ, Smith AG. Fragment screening against the thiamine pyrophosphate riboswitch thiM Chemical Science. 2: 157-165. DOI: 10.1039/c0sc00406e |
1 |
|
| 2011 |
Wu N, Courtois F, Surjadi R, Oakeshott J, Peat TS, Easton CJ, Abell C, Zhu Y. Enzyme synthesis and activity assay in microfluidic droplets on a chip Engineering in Life Sciences. 11: 157-164. DOI: 10.1002/elsc.201000043 |
1 |
|
| 2010 |
Schaerli Y, Stein V, Spiering MM, Benkovic SJ, Abell C, Hollfelder F. Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification. Nucleic Acids Research. 38: e201. PMID 20921065 DOI: 10.1093/nar/gkq795 |
1 |
|
| 2010 |
Wu N, Courtois F, Zhu Y, Oakeshott J, Easton C, Abell C. Management of the diffusion of 4-methylumbelliferone across phases in microdroplet-based systems for in vitro protein evolution. Electrophoresis. 31: 3121-8. PMID 20803501 DOI: 10.1002/elps.201000140 |
1 |
|
| 2010 |
Holt DJ, Payne RJ, Chow WY, Abell C. Fluorosurfactants for microdroplets: interfacial tension analysis. Journal of Colloid and Interface Science. 350: 205-11. PMID 20638074 DOI: 10.1016/j.jcis.2010.06.036 |
1 |
|
| 2010 |
Theberge AB, Courtois F, Schaerli Y, Fischlechner M, Abell C, Hollfelder F, Huck WT. Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. Angewandte Chemie (International Ed. in English). 49: 5846-68. PMID 20572214 DOI: 10.1002/anie.200906653 |
1 |
|
| 2010 |
Payne RJ, Bulloch EM, Kerbarh O, Abell C. Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues. Organic & Biomolecular Chemistry. 8: 3534-42. PMID 20532401 DOI: 10.1039/c004062b |
1 |
|
| 2010 |
Bai Y, He X, Liu D, Patil SN, Bratton D, Huebner A, Hollfelder F, Abell C, Huck WT. A double droplet trap system for studying mass transport across a droplet-droplet interface. Lab On a Chip. 10: 1281-5. PMID 20445881 DOI: 10.1039/b925133b |
1 |
|
| 2010 |
Bauer WA, Fischlechner M, Abell C, Huck WT. Hydrophilic PDMS microchannels for high-throughput formation of oil-in-water microdroplets and water-in-oil-in-water double emulsions. Lab On a Chip. 10: 1814-9. PMID 20442967 DOI: 10.1039/c004046k |
1 |
|
| 2010 |
Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. Journal of the American Chemical Society. 132: 4544-5. PMID 20232910 DOI: 10.1021/ja100595u |
1 |
|
| 2010 |
Coyne AG, Scott DE, Abell C. Drugging challenging targets using fragment-based approaches. Current Opinion in Chemical Biology. 14: 299-307. PMID 20223699 DOI: 10.1016/j.cbpa.2010.02.010 |
1 |
|
| 2010 |
Batchelor M, Zhou D, Cooper MA, Abell C, Rayment T. Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy. Organic & Biomolecular Chemistry. 8: 1142-8. PMID 20165806 DOI: 10.1039/b919347b |
1 |
|
| 2010 |
Chen L, Cressina E, Leeper FJ, Smith AG, Abell C. A fragment-based approach to identifying ligands for riboswitches. Acs Chemical Biology. 5: 355-8. PMID 20158266 DOI: 10.1021/cb9003139 |
1 |
|
| 2010 |
Filler AG, Whiteside GT, Bacon M, Frederickson M, Howe FA, Rabinowitz MD, Sokoloff AJ, Deacon TW, Abell C, Munglani R, Griffiths JR, Bell BA, Lever AM. Tri-partite complex for axonal transport drug delivery achieves pharmacological effect. Bmc Neuroscience. 11: 8. PMID 20085661 DOI: 10.1186/1471-2202-11-8 |
1 |
|
| 2010 |
Sridharan S, Howard N, Kerbarh O, B?aszczyk M, Abell C, Blundell TL. Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes. Journal of Molecular Biology. 397: 290-300. PMID 20079748 DOI: 10.1016/j.jmb.2010.01.019 |
1 |
|
| 2010 |
Holt DJ, Payne RJ, Abell C. Synthesis of novel fluorous surfactants for microdroplet stabilisation in fluorous oil streams Journal of Fluorine Chemistry. 131: 398-407. DOI: 10.1016/j.jfluchem.2009.12.010 |
1 |
|
| 2010 |
Shim JU, Patil SN, Hodgkinson JT, Bowden SD, Spring DR, Welch M, Huck WTS, Hollfelder F, Abell C. Induction of quorum sensing in microdroplets by transporting small molecule through PDMS 14th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2010, Microtas 2010. 1: 656-658. |
1 |
|
| 2009 |
Scott DE, Dawes GJ, Ando M, Abell C, Ciulli A. A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry. Chembiochem : a European Journal of Chemical Biology. 10: 2772-9. PMID 19827080 DOI: 10.1002/cbic.200900537 |
1 |
|
| 2009 |
Shim JU, Olguin LF, Whyte G, Scott D, Babtie A, Abell C, Huck WT, Hollfelder F. Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments. Journal of the American Chemical Society. 131: 15251-6. PMID 19799429 DOI: 10.1021/ja904823z |
1 |
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| 2009 |
Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angewandte Chemie (International Ed. in English). 48: 8452-6. PMID 19780086 DOI: 10.1002/anie.200903821 |
1 |
|
| 2009 |
Trmcic-Cvitas J, Hasan E, Ramstedt M, Li X, Cooper MA, Abell C, Huck WT, Gautrot JE. Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms. Biomacromolecules. 10: 2885-94. PMID 19761181 DOI: 10.1021/bm900706r |
1 |
|
| 2009 |
Damean N, Olguin LF, Hollfelder F, Abell C, Huck WT. Simultaneous measurement of reactions in microdroplets filled by concentration gradients. Lab On a Chip. 9: 1707-13. PMID 19495454 DOI: 10.1039/b821021g |
1 |
|
| 2009 |
Payne RJ, Bulloch EM, Toscano MM, Jones MA, Kerbarh O, Abell C. Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes. Organic & Biomolecular Chemistry. 7: 2421-9. PMID 19462053 DOI: 10.1039/b901694e |
1 |
|
| 2009 |
Hufnagel H, Huebner A, Gülch C, Güse K, Abell C, Hollfelder F. An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets. Lab On a Chip. 9: 1576-82. PMID 19458865 DOI: 10.1039/b821695a |
1 |
|
| 2009 |
Fidalgo LM, Whyte G, Ruotolo BT, Benesch JL, Stengel F, Abell C, Robinson CV, Huck WT. Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online. Angewandte Chemie (International Ed. in English). 48: 3665-8. PMID 19353614 DOI: 10.1002/anie.200806103 |
1 |
|
| 2009 |
Courtois F, Olguin LF, Whyte G, Theberge AB, Huck WT, Hollfelder F, Abell C. Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays. Analytical Chemistry. 81: 3008-16. PMID 19284775 DOI: 10.1021/ac802658n |
1 |
|
| 2009 |
Huebner A, Bratton D, Whyte G, Yang M, Demello AJ, Abell C, Hollfelder F. Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. Lab On a Chip. 9: 692-8. PMID 19224019 DOI: 10.1039/b813709a |
1 |
|
| 2009 |
Schaerli Y, Wootton RC, Robinson T, Stein V, Dunsby C, Neil MA, French PM, Demello AJ, Abell C, Hollfelder F. Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets. Analytical Chemistry. 81: 302-6. PMID 19055421 DOI: 10.1021/ac802038c |
1 |
|
| 2009 |
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen S, Wei AH, Osborne D, Abell C, Blundell TL. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme Nato Science For Peace and Security Series a: Chemistry and Biology. 21-36. DOI: 10.1007/978-90-481-2339-1-3 |
1 |
|
| 2009 |
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen S, Wei AH, Osborne D, Abell C, Blundell TL. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme Nato Science For Peace and Security Series a: Chemistry and Biology. 21-36. |
1 |
|
| 2009 |
Shim JU, Olguin L, Whyte G, Scott D, Hollfelder F, Abell C, Huck W. Probing cell to cell variations in gene expression using microfluidics Proceedings of Conference, Microtas 2009 - the 13th International Conference On Miniaturized Systems For Chemistry and Life Sciences. 1787-1789. |
1 |
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| 2008 |
Ndieyira JW, Watari M, Barrera AD, Zhou D, Vögtli M, Batchelor M, Cooper MA, Strunz T, Horton MA, Abell C, Rayment T, Aeppli G, McKendry RA. Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug drug resistance. Nature Nanotechnology. 3: 691-6. PMID 18989336 DOI: 10.1038/nnano.2008.275 |
1 |
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| 2008 |
Ciulli A, Scott DE, Ando M, Reyes F, Saldanha SA, Tuck KL, Chirgadze DY, Blundell TL, Abell C. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem : a European Journal of Chemical Biology. 9: 2606-11. PMID 18821554 DOI: 10.1002/cbic.200800437 |
1 |
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| 2008 |
Chakauya E, Coxon KM, Wei M, Macdonald MV, Barsby T, Abell C, Smith AG. Towards engineering increased pantothenate (vitamin B(5)) levels in plants. Plant Molecular Biology. 68: 493-503. PMID 18726075 DOI: 10.1007/s11103-008-9386-5 |
1 |
|
| 2008 |
Huebner A, Olguin LF, Bratton D, Whyte G, Huck WT, de Mello AJ, Edel JB, Abell C, Hollfelder F. Development of quantitative cell-based enzyme assays in microdroplets. Analytical Chemistry. 80: 3890-6. PMID 18399662 DOI: 10.1021/ac800338z |
1 |
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| 2008 |
Fidalgo LM, Whyte G, Bratton D, Kaminski CF, Abell C, Huck WT. From microdroplets to microfluidics: selective emulsion separation in microfluidic devices. Angewandte Chemie (International Ed. in English). 47: 2042-5. PMID 18264960 DOI: 10.1002/anie.200704903 |
1 |
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| 2008 |
Courtois F, Olguin LF, Whyte G, Bratton D, Huck WT, Abell C, Hollfelder F. An integrated device for monitoring time-dependent in vitro expression from single genes in picolitre droplets. Chembiochem : a European Journal of Chemical Biology. 9: 439-46. PMID 18232037 DOI: 10.1002/cbic.200700536 |
1 |
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| 2008 |
Zhou D, Ying L, Hong X, Hall EA, Abell C, Klenerman D. A compact functional quantum Dot-DNA conjugate: preparation, hybridization, and specific label-free DNA detection. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 1659-64. PMID 18193909 DOI: 10.1021/la703583u |
1 |
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| 2008 |
Li X, Abell C, Cooper MA. Single-step biocompatible coating for sulfhydryl coupling of receptors using 2-(pyridinyldithio)ethylcarbamoyl dextran. Colloids and Surfaces. B, Biointerfaces. 61: 113-7. PMID 17703925 DOI: 10.1016/j.colsurfb.2007.06.026 |
1 |
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| 2008 |
Shim JU, Olguin L, Whyte G, Bratton D, Hollfelder F, Abell C, Huck W. Kinetics of protein expression in single cells using microfluidics 12th International Conference On Miniaturized Systems For Chemistry and Life Sciences - the Proceedings of Microtas 2008 Conference. 1940-1942. |
1 |
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| 2007 |
Kamper SG, Porter-Peden L, Blankespoor R, Sinniah K, Zhou D, Abell C, Rayment T. Investigating the specific interactions between carbonic anhydrase and a sulfonamide inhibitor by single-molecule force spectroscopy. Langmuir : the Acs Journal of Surfaces and Colloids. 23: 12561-5. PMID 17973506 DOI: 10.1021/la702148v |
1 |
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| 2007 |
Ciulli A, Abell C. Fragment-based approaches to enzyme inhibition. Current Opinion in Biotechnology. 18: 489-96. PMID 17959370 DOI: 10.1016/j.copbio.2007.09.003 |
1 |
|
| 2007 |
Scott DE, Ciulli A, Abell C. Coenzyme biosynthesis: enzyme mechanism, structure and inhibition. Natural Product Reports. 24: 1009-26. PMID 17898895 DOI: 10.1039/b703108b |
1 |
|
| 2007 |
Fidalgo LM, Abell C, Huck WT. Surface-induced droplet fusion in microfluidic devices. Lab On a Chip. 7: 984-6. PMID 17653339 DOI: 10.1039/b708091c |
1 |
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| 2007 |
Payne RJ, Riboldi-Tunnicliffe A, Kerbarh O, Abell AD, Lapthorn AJ, Abell C. Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases. Chemmedchem. 2: 1010-3. PMID 17487901 DOI: 10.1002/cmdc.200700062 |
1 |
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| 2007 |
Payne RJ, Peyrot F, Kerbarh O, Abell AD, Abell C. Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors. Chemmedchem. 2: 1015-29. PMID 17487900 DOI: 10.1002/cmdc.200700032 |
1 |
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| 2007 |
Huebner A, Srisa-Art M, Holt D, Abell C, Hollfelder F, deMello AJ, Edel JB. Quantitative detection of protein expression in single cells using droplet microfluidics. Chemical Communications (Cambridge, England). 1218-20. PMID 17356761 DOI: 10.1039/b618570c |
0.32 |
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| 2007 |
Kerbarh O, Ciulli A, Chirgadze DY, Blundell TL, Abell C. Nucleophile selectivity of chorismate-utilizing enzymes. Chembiochem : a European Journal of Chemical Biology. 8: 622-4. PMID 17335098 DOI: 10.1002/cbic.200700019 |
1 |
|
| 2007 |
Ciulli A, Lobley CM, Tuck KL, Smith AG, Blundell TL, Abell C. pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study. Acta Crystallographica. Section D, Biological Crystallography. 63: 171-8. PMID 17242510 DOI: 10.1107/S0907444906044465 |
1 |
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| 2007 |
Ciulli A, Chirgadze DY, Smith AG, Blundell TL, Abell C. Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: Substrate recognition, conformational change, and cooperativity Journal of Biological Chemistry. 282: 8487-8497. PMID 17229734 DOI: 10.1074/jbc.M611171200 |
1 |
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| 2007 |
Toscano MD, Payne RJ, Chiba A, Kerbarh O, Abell C. Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism. Chemmedchem. 2: 101-12. PMID 17068841 DOI: 10.1002/cmdc.200600194 |
1 |
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| 2007 |
Ciulli A, Blundell TL, Abell C. Discovery and extrapolation of fragment structures towards drug design Rsc Biomolecular Sciences. 293-318. |
1 |
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| 2006 |
Tuck KL, Saldanha SA, Birch LM, Smith AG, Abell C. The design and synthesis of inhibitors of pantothenate synthetase. Organic & Biomolecular Chemistry. 4: 3598-610. PMID 16990935 DOI: 10.1039/b609482a |
1 |
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| 2006 |
Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Probing hot spots at protein-ligand binding sites: A fragment-based approach using biophysical methods Journal of Medicinal Chemistry. 49: 4992-5000. PMID 16884311 DOI: 10.1021/jm060490r |
1 |
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| 2006 |
Rauf S, Zhou D, Abell C, Klenerman D, Kang DJ. Building three-dimensional nanostructures with active enzymes by surface templated layer-by-layer assembly. Chemical Communications (Cambridge, England). 1721-3. PMID 16609783 DOI: 10.1039/b517557g |
1 |
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| 2006 |
Manzanera M, Frankel DJ, Li H, Zhou D, Bruckbauer A, Kreutzmann P, Blackburn JM, Abell C, Rayment T, Klenerman D, Barker PD. Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes. Nano Letters. 6: 365-70. PMID 16522024 DOI: 10.1021/nl051599+ |
1 |
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| 2006 |
Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. Journal of Medicinal Chemistry. 49: 1346-55. PMID 16480269 DOI: 10.1021/jm050850v |
1 |
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| 2006 |
Liu D, Bruckbauer A, Abell C, Balasubramanian S, Kang DJ, Klenerman D, Zhou D. A reversible pH-driven DNA nanoswitch array. Journal of the American Chemical Society. 128: 2067-71. PMID 16464109 DOI: 10.1021/ja0568300 |
1 |
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| 2006 |
Kerbarh O, Chirgadze DY, Blundell TL, Abell C. Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate Journal of Molecular Biology. 357: 524-534. PMID 16434053 DOI: 10.1016/j.jmb.2005.12.078 |
1 |
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| 2006 |
Wang X, Zhou D, Sinniah K, Clarke C, Birch L, Li H, Rayment T, Abell C. Electrostatic orientation of enzymes on surfaces for ligand screening probed by force spectroscopy. Langmuir : the Acs Journal of Surfaces and Colloids. 22: 887-92. PMID 16430243 DOI: 10.1021/la0525731 |
1 |
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| 2005 |
Payne RJ, Bulloch EM, Abell AD, Abell C. Design and synthesis of aromatic inhibitors of anthranilate synthase. Organic & Biomolecular Chemistry. 3: 3629-35. PMID 16211099 DOI: 10.1039/b510633h |
1 |
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| 2005 |
Zhou D, Piper JD, Abell C, Klenerman D, Kang DJ, Ying L. Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA. Chemical Communications (Cambridge, England). 4807-9. PMID 16193121 DOI: 10.1039/b508911e |
1 |
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| 2005 |
Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C. Rational design of new bifunctional inhibitors of type II dehydroquinase Organic and Biomolecular Chemistry. 3: 3102-3104. PMID 16106291 DOI: 10.1039/b507156a |
1 |
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| 2005 |
Kerbarh O, Bulloch EM, Payne RJ, Sahr T, Rébeillé F, Abell C. Mechanistic and inhibition studies of chorismate-utilizing enzymes. Biochemical Society Transactions. 33: 763-6. PMID 16042594 DOI: 10.1042/BST0330763 |
1 |
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| 2005 |
Payne RJ, Toscano MD, Bulloch EM, Abell AD, Abell C. Design and synthesis of aromatic inhibitors of anthranilate synthase. Organic & Biomolecular Chemistry. 3: 2271-81. PMID 16010361 DOI: 10.1039/b503802b |
0.56 |
|
| 2005 |
Lobley CM, Ciulli A, Whitney HM, Williams G, Smith AG, Abell C, Blundell TL. The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. Biochemistry. 44: 8930-9. PMID 15966718 DOI: 10.1021/bi0502036 |
1 |
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| 2005 |
Payne RJ, Kerbarh O, Miguel RN, Abell AD, Abell C. Inhibition studies on salicylate synthase. Organic & Biomolecular Chemistry. 3: 1825-7. PMID 15889161 DOI: 10.1039/b503800f |
1 |
|
| 2004 |
Webb ME, Smith AG, Abell C. Biosynthesis of pantothenate. Natural Product Reports. 21: 695-721. PMID 15565250 DOI: 10.1039/b316419p |
0.44 |
|
| 2004 |
Zhou D, Bruckbauer A, Batchelor M, Kang DJ, Abell C, Klenerman D. Influence of the foundation layer on the layer-by-layer assembly of poly-L-lysine and poly(styrenesulfonate) and its usage in the fabrication of 3D microscale features. Langmuir : the Acs Journal of Surfaces and Colloids. 20: 9089-94. PMID 15461491 DOI: 10.1021/la048619s |
1 |
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| 2004 |
Bulloch EM, Jones MA, Parker EJ, Osborne AP, Stephens E, Davies GM, Coggins JR, Abell C. Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6s)-6-fluoroshikimate. Journal of the American Chemical Society. 126: 9912-3. PMID 15303852 DOI: 10.1021/ja048312f |
1 |
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| 2004 |
Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C. (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases Organic and Biomolecular Chemistry. 2: 1592-1596. PMID 15162210 DOI: 10.1039/b404535a |
1 |
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| 2004 |
Bruckbauer A, Zhou D, Kang DJ, Korchev YE, Abell C, Klenerman D. An addressable antibody nanoarray produced on a nanostructured surface. Journal of the American Chemical Society. 126: 6508-9. PMID 15161251 DOI: 10.1021/ja0317426 |
1 |
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| 2004 |
Ottenhof HH, Ashurst JL, Whitney HM, Saldanha SA, Schmitzberger F, Gweon HS, Blundell TL, Abell C, Smith AG. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. The Plant Journal : For Cell and Molecular Biology. 37: 61-72. PMID 14675432 DOI: 10.1046/j.1365-313X.2003.01940.x |
1 |
|
| 2003 |
Webb ME, Stephens E, Smith AG, Abell C. Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites. Chemical Communications (Cambridge, England). 2416-7. PMID 14587709 DOI: 10.1039/B308182F |
0.44 |
|
| 2003 |
Frederickson M, Parker EJ, Coggins JR, Abell C. Enzymic synthesis of 3-[3- 13C]dehydroquinic acid. Organic & Biomolecular Chemistry. 1: 3271-3. PMID 14584789 |
0.6 |
|
| 2003 |
Zhou D, Sinniah K, Abell C, Rayment T. Label-free detection of DNA hybridization at the nanoscale: a highly sensitive and selective approach using atomic-force microscopy. Angewandte Chemie (International Ed. in English). 42: 4934-7. PMID 14579443 DOI: 10.1002/anie.200352178 |
1 |
|
| 2003 |
Von Delft F, Inoue T, Saldanha SA, Ottenhof HH, Schmitzberger F, Birch LM, Dhanaraj V, Witty M, Smith AG, Blundell TL, Abell C. Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites Structure. 11: 985-996. PMID 12906829 DOI: 10.1016/S0969-2126(03)00158-8 |
1 |
|
| 2003 |
Bruckbauer A, Zhou D, Ying L, Korchev YE, Abell C, Klenerman D. Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet. Journal of the American Chemical Society. 125: 9834-9. PMID 12904050 DOI: 10.1021/ja035755v |
1 |
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| 2003 |
Lobley CM, Schmitzberger F, Kilkenny ML, Whitney H, Ottenhof HH, Chakauya E, Webb ME, Birch LM, Tuck KL, Abell C, Smith AG, Blundell TL. Structural insights into the evolution of the pantothenate-biosynthesis pathway. Biochemical Society Transactions. 31: 563-71. PMID 12773157 DOI: 10.1042/ |
1 |
|
| 2003 |
Wang X, Zhou D, Rayment T, Abell C. Systematic manipulation of surface chemical reaction on the nanoscale: a novel approach for constructing three-dimensional nanostructures. Chemical Communications (Cambridge, England). 474-5. PMID 12638956 |
1 |
|
| 2003 |
Le Sann C, Abell C, Abell AD. A convenient method for the synthesis of dehydroquinic acid Synthetic Communications. 33: 527-533. DOI: 10.1081/SCC-120015805 |
1 |
|
| 2003 |
Frederickson M, Parker EJ, Coggins JR, Abell C. Enzymic synthesis of 3-[3-13C]dehydroquinic acid Organic and Biomolecular Chemistry. 1: 3271-3273. DOI: 10.1039/b309666a |
1 |
|
| 2003 |
Toscano MD, Frederickson M, Evans DP, Coggins JR, Abell C, González-Bello C. Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase Organic and Biomolecular Chemistry. 1: 2075-2083. DOI: 10.1039/b301731a |
1 |
|
| 2003 |
Zhou D, Wang X, Birch L, Rayment T, Abell C. AFM study on protein immobilization on charged surfaces at the nanoscale: Toward the fabrication of three-dimensional protein nanostructures Langmuir. 19: 10557-10562. DOI: 10.1021/la035491q |
1 |
|
| 2003 |
Frederickson M, Vuillard L, Abell C. Novel selenium containing non-detergent sulphobetaines Tetrahedron Letters. 44: 7925-7928. DOI: 10.1016/j.tetlet.2003.09.004 |
1 |
|
| 2002 |
Todd MH, Abell C. The use of FTICR-MS to detect chemical tags from a combinatorial library. The Analyst. 127: 1399-406. PMID 12475024 DOI: 10.1039/b203957p |
1 |
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| 2002 |
Bruckbauer A, Ying L, Rothery AM, Zhou D, Shevchuk AI, Abell C, Korchev YE, Klenerman D. Writing with DNA and protein using a nanopipet for controlled delivery. Journal of the American Chemical Society. 124: 8810-1. PMID 12137530 DOI: 10.1021/ja026816c |
1 |
|
| 2002 |
Roszak AW, Robinson DA, Krell T, Hunter IS, Fredrickson M, Abell C, Coggins JR, Lapthorn AJ. The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure (London, England : 1993). 10: 493-503. PMID 11937054 DOI: 10.1016/S0969-2126(02)00747-5 |
0.6 |
|
| 2002 |
Frederickson M, Coggins JR, Abell C. Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases Chemical Communications. 8: 1886-1887. DOI: 10.1039/b205105m |
1 |
|
| 2002 |
Le Sann C, Abell C, Abell AD. A simple method for the preparation of 3-hydroxyiminodehydroquinate, a potent inhibitor of type II dehydroquinase Journal of the Chemical Society. Perkin Transactions 1. 2065-2068. |
1 |
|
| 2001 |
Tomkins JM, Abell C. Preparation of symmetrical and unsymmetrical DNA - Protein conjugates with DNA as a molecular scaffold Chembiochem. 2: 375-378. PMID 11828468 DOI: 10.1002/1439-7633(20010504)2:5<375::AID-CBIC375>3.0.CO;2-I |
1 |
|
| 2001 |
Parker EJ, Bulloch EM, Jameson GB, Abell C. Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase by erythrose 4-phosphate. Biochemistry. 40: 14821-8. PMID 11732901 |
0.6 |
|
| 2001 |
Todd MH, Abell C. Novel chemical tagging method for combinatorial synthesis utilizing suzuki chemistry and fourier transform ion cyclotron resonance mass spectrometry. Journal of Combinatorial Chemistry. 3: 319-27. PMID 11350256 DOI: 10.1021/cc000112m |
1 |
|
| 2000 |
Parker EJ, González Bello C, Coggins JR, Hawkins AR, Abell C. Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids. Bioorganic & Medicinal Chemistry Letters. 10: 231-4. PMID 10698442 DOI: 10.1016/S0960-894X(99)00660-5 |
1 |
|
| 2000 |
Todd MH, Abell C. The attachment and cleavage of phenols from solid supports and their single bead mass spectral analysis Tetrahedron Letters. 41: 8183-8187. |
1 |
|
| 1999 |
Frederickson M, Parker EJ, Hawkins AR, Coggins JR, Abell C. Selective Inhibition of Type II Dehydroquinases. The Journal of Organic Chemistry. 64: 2612-2613. PMID 11674325 DOI: 10.1021/jo990004q |
1 |
|
| 1999 |
Todd MH, Oliver SF, Abell C. A novel safety-catch linker for the solid-phase synthesis of amides and esters Organic Letters. 1: 1149-1151. |
1 |
|
| 1997 |
Parker EJ, Coggins JR, Abell C. Derailing Dehydroquinate Synthase by Introducing a Stabilizing Stereoelectronic Effect in a Reaction Intermediate. The Journal of Organic Chemistry. 62: 8582-8585. PMID 11672011 |
1 |
|
| 1997 |
Todd MH, Balasubramanian S, Abell C. Studies on the synthesis, characterisation and reactivity of aromatic diboronic acids Tetrahedron Letters. 38: 6781-6784. DOI: 10.1016/S0040-4039(97)01552-9 |
1 |
|
| 1997 |
Arumugam V, Routledge A, Abell C, Balasubramanian S. Synthesis of 2-oxindole derivatives via the intramolecular Heck reaction on solid support Tetrahedron Letters. 38: 6473-6476. DOI: 10.1016/S0040-4039(97)01481-0 |
1 |
|
| 1997 |
Tomkins JM, Barnes KJ, Blacker AJ, Watkins WJ, Abell C. Lipophilic modification of oligonucleotides Tetrahedron Letters. 38: 691-694. DOI: 10.1016/S0040-4039(96)02394-5 |
1 |
|
| 1995 |
Bornemann S, Balasubramanian S, Coggins JR, Abell C, Lowe DJ, Thorneley RN. Escherichia coli chorismate synthase: a deuterium kinetic-isotope effect under single-turnover and steady-state conditions shows that a flavin intermediate forms before the C-(6proR)-H bond is cleaved. The Biochemical Journal. 305: 707-10. PMID 7848266 |
1 |
|
| 1995 |
Borthwick EB, Connell SJ, Tudor DW, Robins DJ, Shneier A, Abell C, Coggins JR. Escherichia coli dihydrodipicolinate synthase: characterization of the imine intermediate and the product of bromopyruvate treatment by electrospray mass spectrometry. The Biochemical Journal. 305: 521-4. PMID 7832769 DOI: 10.1042/bj3050521 |
0.6 |
|
| 1995 |
Balasubramanian S, Coggins JR, Abell C. Observation of a secondary tritium isotope effect in the chorismate synthase reaction. Biochemistry. 34: 341-8. PMID 7819217 |
1 |
|
| 1995 |
Bornemann S, Ramjee MK, Balasubramanian S, Abell C, Coggins JR, Lowe DJ, Thorneley RN. Escherichia coli chorismate synthase catalyzes the conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate. Implications for the enzyme mechanism and the antimicrobial action of (6S)-6-fluoroshikimate. The Journal of Biological Chemistry. 270: 22811-5. PMID 7559411 DOI: 10.1074/jbc.270.39.22811 |
1 |
|
| 1995 |
Duggan PJ, Parker E, Coggins J, Abell C. Enzymatic synthesis of (6R)- and (6S)-fluoroshikimic acids Bioorganic and Medicinal Chemistry Letters. 5: 2347-2352. DOI: 10.1016/0960-894X(95)00405-I |
1 |
|
| 1993 |
Hädener A, Matzinger PK, Malashkevich VN, Louie GV, Wood SP, Oliver P, Alefounder PR, Pitt AR, Abell C, Battersby AR. Purification, characterization, crystallisation and X-ray analysis of selenomethionine-labelled hydroxymethylbilane synthase from Escherichia coli. European Journal of Biochemistry / Febs. 211: 615-24. PMID 8436121 DOI: 10.1111/j.1432-1033.1993.tb17589.x |
1 |
|
| 1993 |
Jones CE, Brook JM, Buck D, Abell C, Smith AG. Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme. Journal of Bacteriology. 175: 2125-30. PMID 8096212 DOI: 10.1128/jb.175.7.2125-2130.1993 |
0.44 |
|
| 1992 |
Thorneley RN, Abell C, Ashby GA, Drummond MH, Eady RR, Huff S, Macdonald CJ, Shneier A. Posttranslational modification of Klebsiella pneumoniae flavodoxin by covalent attachment of coenzyme A, shown by 31P NMR and electrospray mass spectrometry, prevents electron transfer from the nifJ protein to nitrogenase. A possible new regulatory mechanism for biological nitrogen fixation. Biochemistry. 31: 1216-24. PMID 1734967 DOI: 10.1021/bi00119a035 |
1 |
|
| 1991 |
Cane DE, Abell C, Harrison PH, Hubbard BR, Kane CT, Lattman R, Oliver JS, Weiner SW. Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 332: 123-9. PMID 1678531 DOI: 10.1098/rstb.1991.0040 |
1 |
|
| 1991 |
Balasubramanian S, Abell C. The synthesis of (6R)-[6-2H]- and (6S)-[6-2H]5-enolpyruvylshikimate-3-phosphate Tetrahedron Letters. 32: 963-966. DOI: 10.1016/S0040-4039(00)92131-2 |
1 |
|
| 1991 |
Crockett N, Alefounder PR, Battersby AR, Abell C. Uroporphyrinogen III synthase: Studies on its mechanism of action, molecular biology and biochemistry Tetrahedron. 47: 6003-6014. DOI: 10.1016/S0040-4020(01)86492-9 |
1 |
|
| 1990 |
Hädener A, Alefounder PR, Hart GJ, Abell C, Battersby AR. Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine. The Biochemical Journal. 271: 487-91. PMID 2122889 DOI: 10.1042/bj2710487 |
1 |
|
| 1990 |
Cane DE, Oliver JS, Harrison PHM, Abell C, Hubbard BR, Kane CT, Lattman R. Biosynthesis of pentalenene and pentalenolactone Journal of the American Chemical Society. 112: 4513-4524. DOI: 10.1021/ja00167a059 |
1 |
|
| 1989 |
Miller AD, Packman LC, Hart GJ, Alefounder PR, Abell C, Battersby AR. Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase). The Biochemical Journal. 262: 119-24. PMID 2510713 DOI: 10.1042/bj2620119 |
1 |
|
| 1989 |
Alefounder PR, Hart GJ, Miller AD, Beifuss U, Abell C, Leeper FJ, Battersby AR. Biosynthesis of the pigments of life: Structure and mode of action of a novel enzymatic cofactor Bioorganic Chemistry. 17: 121-129. DOI: 10.1016/0045-2068(89)90013-8 |
1 |
|
| 1988 |
Alefounder PR, Abell C, Battersby AR. The sequence of hemC, hemD and two additional E. coli genes. Nucleic Acids Research. 16: 9871. PMID 3054815 DOI: 10.1093/nar/16.20.9871 |
1 |
|
| 1986 |
Hart GJ, Abell C, Battersby AR. Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli. The Biochemical Journal. 240: 273-6. PMID 3548707 DOI: 10.1042/bj2400273 |
1 |
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