Christopher Abell, Ph.D. - Related publications

1994-1999 Biological Chemistry University of Cambridge, Cambridge, England, United Kingdom 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Hamdy R, Fayed B, Mostafa A, Shama NMA, Mahmoud SH, Mehta CH, Nayak Y, M Soliman SS. Iterated Virtual Screening-Assisted Antiviral and Enzyme Inhibition Assays Reveal the Discovery of Novel Promising Anti-SARS-CoV-2 with Dual Activity. International Journal of Molecular Sciences. 22. PMID 34445763 DOI: 10.3390/ijms22169057   
2021 Hernández-Ochoa B, Navarrete-Vázquez G, Aguayo-Ortiz R, Ortiz-Ramírez P, Morales-Luna L, Martínez-Rosas V, González-Valdez A, Gómez-Chávez F, Enríquez-Flores S, Wong-Baeza C, Baeza-Ramírez I, Pérez de la Cruz V, Gómez-Manzo S. Identification and In Silico Characterization of Novel Glucose-6-Phosphate Dehydrogenase Inhibitors. Molecules (Basel, Switzerland). 26. PMID 34443540 DOI: 10.3390/molecules26164955   
2021 Pokhrel S, Bouback TA, Samad A, Nur SM, Alam R, Abdullah-Al-Mamun M, Nain Z, Imon RR, Talukder MEK, Tareq MMI, Hossen MS, Karpiński TM, Ahammad F, Qadri I, Rahman MS. Spike protein recognizer receptor ACE2 targeted identification of potential natural antiviral drug candidates against SARS-CoV-2. International Journal of Biological Macromolecules. PMID 34592225 DOI: 10.1016/j.ijbiomac.2021.09.146   
2021 Gabrielli V, Muñoz-García JC, Pergolizzi G, de Andrade P, Khimyak Y, Field RA, Angulo J. Molecular recognition of natural and non-natural substrates by cellodextrin phosphorylase from Ruminiclostridium thermocellum investigated by NMR spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34436794 DOI: 10.1002/chem.202102039   
2021 Song L, Merceron R, Hulpia F, Lucía A, Gracia B, Jian Y, Risseeuw MDP, Verstraelen T, Cos P, Aínsa JA, Boshoff HI, Munier-Lehmann H, Savvides SN, Van Calenbergh S. Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors. European Journal of Medicinal Chemistry. 225: 113784. PMID 34450493 DOI: 10.1016/j.ejmech.2021.113784   
2021 Weiss AKH, Wurzer R, Klapec P, Eder MP, Loeffler JR, von Grafenstein S, Monteleone S, Liedl KR, Jansen-Dürr P, Gstach H. Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1). Molecules (Basel, Switzerland). 26. PMID 34443596 DOI: 10.3390/molecules26165009   
2021 DeLaney C, Sheng Y, Pectol DC, Vantansever E, Zhang H, Bhuvanesh N, Salas I, Liu WR, Fierke CF, Darensbourg MY. Zinc thiotropolone combinations as inhibitors of the SARS-CoV-2 main protease. Dalton Transactions (Cambridge, England : 2003). PMID 34396374 DOI: 10.1039/d1dt02499j   
2021 Somma V, Calvio C, Rabuffetti M, Rama E, Speranza G, Morelli CF. An overall framework for the E. coli γ-glutamyltransferase-catalyzed transpeptidation reactions. Bioorganic Chemistry. 115: 105217. PMID 34364051 DOI: 10.1016/j.bioorg.2021.105217   
2021 Friday SN, Cheng DW, Zagler SG, Zanella BS, Dietz JD, Calbat CN, Roach LT, Bagnal C, Faile IS, Halkides CJ, Viola RE. Design and testing of selective inactivators against an antifungal enzyme target. Drug Development Research. PMID 34469014 DOI: 10.1002/ddr.21875   
2021 Wang Y, Hanrahan G, Azar FA, Mittermaier A. Binding interactions in a kinase active site modulate background ATP hydrolysis. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140720. PMID 34597835 DOI: 10.1016/j.bbapap.2021.140720   
2021 Kröß C, Engele P, Sprenger B, Fischer A, Lingg N, Baier M, Öhlknecht C, Lier B, Oostenbrink C, Cserjan-Puschmann M, Striedner G, Jungbauer A, Schneider R. PROFICS: A bacterial selection system for directed evolution of proteases. The Journal of Biological Chemistry. 101095. PMID 34418435 DOI: 10.1016/j.jbc.2021.101095   
2021 Hamdan SH, Maiangwa J, Ali MSM, Normi YM, Sabri S, Leow TC. Thermostable lipases and their dynamics of improved enzymatic properties. Applied Microbiology and Biotechnology. PMID 34487207 DOI: 10.1007/s00253-021-11520-7   
2021 Mota C, Diniz A, Coelho C, Santos-Silva T, Esmaeeli M, Leimkühler S, Cabrita EJ, Marcelo F, Romão MJ. Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case. Journal of Medicinal Chemistry. PMID 34415167 DOI: 10.1021/acs.jmedchem.1c01125   
2021 Bahadur Gurung A, Ajmal Ali M, Lee J, Abul Farah M, Mashay Al-Anazi K, Al-Hemaid F. Identification of SARS-CoV-2 inhibitors from extracts of Thunb. Saudi Journal of Biological Sciences. PMID 34512097 DOI: 10.1016/j.sjbs.2021.08.100   
2021 Wang Y, Mittermaier AK. Characterizing Bi-substrate Enzyme Kinetics at High Resolution by 2D-ITC. Analytical Chemistry. PMID 34514786 DOI: 10.1021/acs.analchem.1c02705   
2021 Jia Q, Zeng H, Li H, Xiao N, Tang J, Gao S, Zhang J, Xie W. The C-terminal loop of guanosine deaminase is essential to catalysis. Chemical Communications (Cambridge, England). PMID 34477187 DOI: 10.1039/d1cc03042f   
2021 Rice AJ, Pesavento RP, Ren J, Youn I, Kwon Y, Ellepola K, Che CT, Johnson ME, Lee H. Identification of Small Molecule Inhibitors against Dihydroorotase via HTS. International Journal of Molecular Sciences. 22. PMID 34576147 DOI: 10.3390/ijms22189984   
2021 Jiménez T, Botero J, Otaegui D, Calvo J, Hernandez FJ, San Sebastian E. Rational Design and Experimental Analysis of Short-Oligonucleotide Substrate Specificity for Targeting Bacterial Nucleases. Journal of Medicinal Chemistry. PMID 34460263 DOI: 10.1021/acs.jmedchem.1c00884   
2021 Tohar R, Ansbacher T, Sher I, Afriat-Jurnou L, Weinberg E, Gal M. Screening Collagenase Activity in Bacterial Lysate for Directed Enzyme Applications. International Journal of Molecular Sciences. 22. PMID 34445258 DOI: 10.3390/ijms22168552   
2021 Prasher P, Sharma M. Medicinal chemistry of pyrophosphate mimics: A mini review. Drug Development Research. PMID 34506652 DOI: 10.1002/ddr.21877   
2021 Kujawa J, Głodek M, Li G, Al-Gharabli S, Knozowska K, Kujawski W. Highly effective enzymes immobilization on ceramics: Requirements for supports and enzymes. The Science of the Total Environment. 801: 149647. PMID 34467928 DOI: 10.1016/j.scitotenv.2021.149647   
2021 Sherry D, Worth R, Sayed Y. Elasticity-Associated Functionality and Inhibition of the HIV Protease. Advances in Experimental Medicine and Biology. PMID 34351572 DOI: 10.1007/5584_2021_655   
2021 Kumar S, Nair AS, Bhashkar V, Sudevan ST, Koyiparambath VP, Khames A, Abdelgawad MA, Mathew B. Navigating into the Chemical Space of Monoamine Oxidase Inhibitors by Artificial Intelligence and Cheminformatics Approach. Acs Omega. 6: 23399-23411. PMID 34549139 DOI: 10.1021/acsomega.1c03250   
2021 Li C, Zhang W, Wei C, Gao X, Mao S, Lu F, Qin HM. Continuous Spectrophotometric Assay for High-Throughput Screening of Predominant d-Allulose 3-Epimerases. Journal of Agricultural and Food Chemistry. PMID 34569239 DOI: 10.1021/acs.jafc.1c04716   
2021 Chakraborty K, Dhara S. Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties. Phytochemistry. 191: 112909. PMID 34419665 DOI: 10.1016/j.phytochem.2021.112909   
2021 Li Q, Pan Y, Li H, Lenertz M, Reed K, Jordahl D, Bjerke T, Ugrinov A, Chen B, Yang Z. Cascade/Parallel Biocatalysis via Multi-enzyme Encapsulation on Metal-Organic Materials for Rapid and Sustainable Biomass Degradation. Acs Applied Materials & Interfaces. PMID 34478257 DOI: 10.1021/acsami.1c12209   
2021 Wu H, Chen Q, Zhang W, Mu W. Overview of strategies for developing high thermostability industrial enzymes: Discovery, mechanism, modification and challenges. Critical Reviews in Food Science and Nutrition. 1-18. PMID 34445912 DOI: 10.1080/10408398.2021.1970508   
2021 Currie MJ, Manjunath L, Horne CR, Rendle PM, Subramanian R, Friemann R, Fairbanks AJ, Muscroft-Taylor AC, North RA, Dobson RCJ. N-Acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization. The Journal of Biological Chemistry. 101113. PMID 34437902 DOI: 10.1016/j.jbc.2021.101113   
2021 Collins AP, Abdelfattah W. Structure-based virtual screening of essential Mycobacterium tuberculosis enzymes AspS and KatG for potential inhibitors. Bioinformation. 17: 101-108. PMID 34393424 DOI: 10.6026/97320630017101   
2021 Kang JM, Lê HG, Na BK, Yoo WG. pH-Dependent Structural Dynamics of Cathepsin D-Family Aspartic Peptidase of . Pathogens (Basel, Switzerland). 10. PMID 34578162 DOI: 10.3390/pathogens10091128   
2021 Lin Z, Wang X, Bustin KA, Shishikura K, McKnight NR, He L, Suciu RM, Hu K, Han X, Ahmadi M, Olson EJ, Parsons WH, Matthews ML. Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. Acs Central Science. 7: 1524-1534. PMID 34584954 DOI: 10.1021/acscentsci.1c00616   
2021 Kummer MJ, Lee YS, Yuan M, Alkotaini B, Zhao J, Blumenthal E, Minteer SD. Substrate Channeling by a Rationally Designed Fusion Protein in a Biocatalytic Cascade. Jacs Au. 1: 1187-1197. PMID 34467357 DOI: 10.1021/jacsau.1c00180   
2021 Lee R, Kim V, Chun Y, Kim D. Structure-Functional Analysis of Human Cytochrome P450 2C8 Using Directed Evolution. Pharmaceutics. 13. PMID 34575505 DOI: 10.3390/pharmaceutics13091429   
2021 Agrawal A, Bandi CK, Burgin T, Woo Y, Mayes HB, Chundawat SPS. Click-Chemistry-Based Free Azide versus Azido Sugar Detection Enables Rapid In Vivo Screening of Glycosynthase Activity. Acs Chemical Biology. PMID 34499469 DOI: 10.1021/acschembio.1c00585   
2021 Erickson E, Shakespeare TJ, Bratti F, Buss BL, Graham R, Hawkins MA, König G, Michener WE, Miscall J, Ramirez KJ, Rorrer NA, Zahn M, Pickford AR, McGeehan JE, Beckham G. Comparative performance of PETase as a function of reaction conditions, substrate properties, and product accumulation. Chemsuschem. PMID 34587366 DOI: 10.1002/cssc.202101932   
2021 Espina G, Atalah J, Blamey JM. Extremophilic Oxidoreductases for the Industry: Five Successful Examples With Promising Projections. Frontiers in Bioengineering and Biotechnology. 9: 710035. PMID 34458243 DOI: 10.3389/fbioe.2021.710035   
2021 Zhang XW, Bian GL, Kang PY, Cheng XJ, Yan K, Liu YL, Gao YX, Li DQ. Recent advance in the discovery of tyrosinase inhibitors from natural sources via separation methods. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 2104-2117. PMID 34579614 DOI: 10.1080/14756366.2021.1983559   
2021 Wang Q, Zhang L. Harnessing P450 enzyme for biotechnology and synthetic biology. Chembiochem : a European Journal of Chemical Biology. PMID 34542923 DOI: 10.1002/cbic.202100439   
2021 Souza SA, Held A, Lu WJ, Drouhard B, Avila B, Leyva-Montes R, Hu M, Miller BR, Ng HL. Mechanisms of allosteric and mixed mode aromatase inhibitors. Rsc Chemical Biology. 2: 892-905. PMID 34458816 DOI: 10.1039/d1cb00046b   
2021 Cui J, Jia J. Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors. European Journal of Medicinal Chemistry. 225: 113789. PMID 34438124 DOI: 10.1016/j.ejmech.2021.113789   
2021 Smith SR, Lyman MJ, Ma B, Tweedie DJ, Menzel K. . Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 34407991 DOI: 10.1124/dmd.121.000601   
2021 Ralbovsky NM, Smith JP. Machine Learning and Chemical Imaging to Elucidate Enzyme Immobilization for Biocatalysis. Analytical Chemistry. PMID 34428014 DOI: 10.1021/acs.analchem.1c01909   
2021 Zhirnov VV, Velihina YS, Mitiukhin OP, Brovarets VS. Intrinsic drug potential of oxazolo[5,4-d]pyrimidines and oxazolo[4,5-d]pyrimidines. Chemical Biology & Drug Design. 98: 561-581. PMID 34148293 DOI: 10.1111/cbdd.13911   
2021 Li Y, Zhang Y, Wu X, Gao Y, Guo J, Tian Y, Lin Z, Wang X. Discovery of natural 15-LOX small molecule inhibitors from Chinese herbal medicine using virtual Screening, biological evaluation and molecular dynamics studies. Bioorganic Chemistry. 115: 105197. PMID 34426159 DOI: 10.1016/j.bioorg.2021.105197   
2021 Wei X, Matsuyama T, Sato H, Yan D, Chan PM, Miyamoto K, Uchiyama M, Matsuda Y. Molecular and Computational Bases for Spirofuranone Formation in Setosusin Biosynthesis. Journal of the American Chemical Society. PMID 34644070 DOI: 10.1021/jacs.1c08336   
2021 Li YM, Yuan J, Ren H, Ji CY, Tao Y, Wu Y, Chou LY, Zhang YB, Cheng L. Fine-Tuning the Micro-Environment to Optimize the Catalytic Activity of Enzymes Immobilized in Multivariate Metal-Organic Frameworks. Journal of the American Chemical Society. PMID 34478271 DOI: 10.1021/jacs.1c07107   
2021 Kurze E, Ruß V, Syam N, Effenberger I, Jonczyk R, Liao J, Song C, Hoffmann T, Schwab W. Glucosylation of (±)-Menthol by Uridine-Diphosphate-Sugar Dependent Glucosyltransferases from Plants. Molecules (Basel, Switzerland). 26. PMID 34576983 DOI: 10.3390/molecules26185511   
2021 Sirota FL, Maurer-Stroh S, Li Z, Eisenhaber F, Eisenhaber B. Functional Classification of Super-Large Families of Enzymes Based on Substrate Binding Pocket Residues for Biocatalysis and Enzyme Engineering Applications. Frontiers in Bioengineering and Biotechnology. 9: 701120. PMID 34409021 DOI: 10.3389/fbioe.2021.701120   
2021 Das BK, Chakraborty D. Deciphering the competitive inhibition of dihydropteroate synthase by 8 marcaptoguanine analogs: enhanced potency in phenylsulfonyl fragments. Journal of Biomolecular Structure & Dynamics. 1-20. PMID 34581241 DOI: 10.1080/07391102.2021.1981452   
2021 Waidha K, Zurgil U, Ben-Zeev E, Gopas J, Rajendran S, Golan-Goldhirsh A. Inhibition of Cysteine Proteases by 6,6'-Dihydroxythiobinupharidine (DTBN) from . Molecules (Basel, Switzerland). 26. PMID 34443335 DOI: 10.3390/molecules26164743