Gregory Douglas Cuny - Publications

Affiliations: 
1992 Pharmacological and Pharmaceutical Sciences University of Houston, Houston, TX, United States 
Area:
medicinal chemistry
Website:
http://www.uh.edu/pharmacy/directory-home/pps-faculty/greg-cuny/

130 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pawlowic MC, Somepalli M, Sateriale A, Herbert GT, Gibson AR, Cuny GD, Hedstrom L, Striepen B. Genetic ablation of purine salvage in reveals nucleotide uptake from the host cell. Proceedings of the National Academy of Sciences of the United States of America. PMID 31570573 DOI: 10.1073/pnas.1908239116  0.4
2018 Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Cuny GD, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/acscentsci.8b00747  0.8
2018 Jiang JK, Huang X, Shamim K, Patel PR, Lee A, Wang AQ, Nguyen K, Tawa G, Cuny GD, Yu PB, Zheng W, Xu X, Sanderson P, Huang W. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 30227946 DOI: 10.1016/j.bmcl.2018.09.006  0.6
2018 Ku AF, Cuny GD. Discovery of 7-hydroxyaporphines as conformationally restricted ligands for beta-1 and beta-2 adrenergic receptors. Medchemcomm. 9: 353-356. PMID 30108929 DOI: 10.1039/c7md00656j  1
2018 Hrdinka M, Schlicher L, Dai B, Pinkas DM, Bufton JC, Picaud S, Ward JA, Rogers C, Suebsuwong C, Nikhar S, Cuny GD, Huber KV, Filippakopoulos P, Bullock AN, Degterev A, et al. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. The Embo Journal. PMID 30026309 DOI: 10.15252/embj.201899372  0.6
2018 Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L. Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents. Journal of Medicinal Chemistry. PMID 29746130 DOI: 10.1021/acs.jmedchem.7b01839  0.4
2018 Suebsuwong C, Pinkas DM, Ray SS, Bufton JC, Dai B, Bullock AN, Degterev A, Cuny GD. Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29409752 DOI: 10.1016/j.bmcl.2018.01.044  0.44
2017 Choi S, Calder AN, Miller EH, Anderson KP, Fiejtek DK, Rietz A, Li H, Cherry JJ, Quist KM, Xing X, Glicksman MA, Cuny GD, Lorson CL, Androphy EA, Hodgetts KJ. Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers. Bioorganic & Medicinal Chemistry Letters. PMID 29103974 DOI: 10.1016/j.bmcl.2017.10.066  0.8
2017 Gorla SK, Zhang Y, Rabideau MM, Qin A, Chacko S, House AL, Johnson CR, Mandapati K, Bernstein HM, McKenney ES, Boshoff H, Zhang M, Glomski IJ, Goldberg JB, Cuny GD, et al. Benzoxazoles, phthalazinones, and arylurea-based compounds with IMPDH-independent antibacterial activity against Francisella tularensis. Antimicrobial Agents and Chemotherapy. PMID 28739786 DOI: 10.1128/AAC.00939-17  0.4
2017 Rietz A, Li H, Quist KM, Cherry JJ, Lorson CL, Burnett B, Kern NL, Calder AN, Fritsche M, Lusic H, Boaler PJ, Choi S, Xing X, Glicksman MA, Cuny GD, et al. Discovery of a Small Molecule Probe that Post-translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. Journal of Medicinal Chemistry. PMID 28481536 DOI: 10.1021/acs.jmedchem.6b01885  0.8
2017 Cuny GD, Suebsuwong C, Ray SS. Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016). Expert Opinion On Therapeutic Patents. PMID 28074661 DOI: 10.1080/13543776.2017.1280463  0.44
2016 Ku AF, Cuny GD. Access to 6a-Alkyl Aporphines: Synthesis of (±)-N-Methylguattescidine. The Journal of Organic Chemistry. PMID 27689544 DOI: 10.1021/acs.joc.6b02024  1
2016 Vippila MR, Nikhar S, Gracia AP, Cuny GD. Divergent Approach for the Synthesis of Gombamide A and Derivatives. Organic Letters. PMID 27603447 DOI: 10.1021/acs.orglett.6b02379  1
2015 Vippila MR, Ly PK, Cuny GD. Synthesis and Antiproliferative Activity Evaluation of the Disulfide-Containing Cyclic Peptide Thiochondrilline C and Derivatives. Journal of Natural Products. 78: 2398-404. PMID 26444379 DOI: 10.1021/acs.jnatprod.5b00428  1
2015 Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. Plos One. 10: e0138976. PMID 26440283 DOI: 10.1371/journal.pone.0138976  1
2015 Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Chemistry & Biology. 22: 1174-84. PMID 26320862 DOI: 10.1016/j.chembiol.2015.07.017  0.44
2015 Lang CA, Ray SS, Liu M, Singh AK, Cuny GD. Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking. Bioorganic & Medicinal Chemistry Letters. 25: 2713-9. PMID 25998502 DOI: 10.1016/j.bmcl.2015.04.027  1
2015 Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L. Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallographica. Section F, Structural Biology Communications. 71: 531-8. PMID 25945705 DOI: 10.1107/S2053230X15000187  1
2015 Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Reports. 10: 1850-60. PMID 25801024 DOI: 10.1016/j.celrep.2015.02.052  1
2015 Takahashi K, Kong Q, Lin Y, Stouffer N, Schulte DA, Lai L, Liu Q, Chang LC, Dominguez S, Xing X, Cuny GD, Hodgetts KJ, Glicksman MA, Lin CL. Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease. The Journal of Experimental Medicine. 212: 319-32. PMID 25711212 DOI: 10.1084/jem.20140413  1
2015 Ku AF, Cuny GD. Synthetic studies of 7-oxygenated aporphine alkaloids: preparation of (-)-oliveroline, (-)-nornuciferidine, and derivatives. Organic Letters. 17: 1134-7. PMID 25710592 DOI: 10.1021/acs.orglett.5b00007  1
2015 Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors Chemistry and Biology. DOI: 10.1016/j.chembiol.2015.07.017  1
2014 Sun Z, Khan J, Makowska-Grzyska M, Zhang M, Cho JH, Suebsuwong C, Vo P, Gollapalli DR, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. Journal of Medicinal Chemistry. 57: 10544-50. PMID 25474504 DOI: 10.1021/jm501527z  1
2014 Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L. Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. Acs Medicinal Chemistry Letters. 5: 846-50. PMID 25147601 DOI: 10.1021/ml500203p  1
2014 Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PB. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. Journal of Medicinal Chemistry. 57: 7900-15. PMID 25101911 DOI: 10.1021/jm501177w  1
2014 Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, et al. Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease. Plos Biology. 12: e1001923. PMID 25093460 DOI: 10.1371/journal.pbio.1001923  1
2014 Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. Journal of Biomolecular Screening. 19: 1024-1034. PMID 24598103 DOI: 10.1177/1087057114525853  1
2014 Kong Q, Chang LC, Takahashi K, Liu Q, Schulte DA, Lai L, Ibabao B, Lin Y, Stouffer N, Das Mukhopadhyay C, Xing X, Seyb KI, Cuny GD, Glicksman MA, Lin CL. Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. The Journal of Clinical Investigation. 124: 1255-67. PMID 24569372 DOI: 10.1172/JCI66163  1
2014 Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L. Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrobial Agents and Chemotherapy. 58: 1603-14. PMID 24366728 DOI: 10.1128/AAC.02075-13  1
2013 Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD, Parmar K. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Molecular Cancer Therapeutics. 12: 2651-62. PMID 24130053 DOI: 10.1158/1535-7163.MCT-13-0103-T  1
2013 Wang X, Cuny GD, Noël T. A mild, one-pot Stadler-Ziegler synthesis of arylsulfides facilitated by photoredox catalysis in batch and continuous-flow. Angewandte Chemie (International Ed. in English). 52: 7860-4. PMID 23784666 DOI: 10.1002/anie.201303483  1
2013 Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ. Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds. Embo Molecular Medicine. 5: 1035-50. PMID 23740718 DOI: 10.1002/emmm.201202305  1
2013 Zhang X, Hernandez I, Rei D, Mair W, Laha JK, Cornwell ME, Cuny GD, Tsai LH, Steen JA, Kosik KS. Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. The Journal of Biological Chemistry. 288: 22042-56. PMID 23737518 DOI: 10.1074/jbc.M112.436402  1
2013 Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 56: 4028-43. PMID 23668331 DOI: 10.1021/jm400241j  1
2013 Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN. A new class of small molecule inhibitor of BMP signaling. Plos One. 8: e62721. PMID 23646137 DOI: 10.1371/journal.pone.0062721  1
2013 Mohedas AH, Xing X, Armstrong KA, Bullock AN, Cuny GD, Yu PB. Development of an ALK2-biased BMP type I receptor kinase inhibitor. Acs Chemical Biology. 8: 1291-302. PMID 23547776 DOI: 10.1021/cb300655w  1
2013 Maki JL, Tres Brazell J, Teng X, Cuny GD, Degterev A. Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system. Protein Expression and Purification. 89: 156-61. PMID 23523699 DOI: 10.1016/j.pep.2013.03.002  1
2013 McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A. Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. Plos One. 8: e56576. PMID 23469174 DOI: 10.1371/journal.pone.0056576  1
2013 Liu M, Bender SA, Cuny GD, Sherman W, Glicksman M, Ray SS. Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S. Biochemistry. 52: 1725-36. PMID 23379419 DOI: 10.1021/bi3012077  1
2013 Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L. Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorganic & Medicinal Chemistry Letters. 23: 1004-7. PMID 23324406 DOI: 10.1016/j.bmcl.2012.12.037  1
2013 Barolo SM, Wang Y, Rossi RA, Cuny GD. Synthesis of pyrido[1,2-a]benzimidazoles by photo-stimulated C-N bond formation via SRN1 reactions Tetrahedron. 69: 5487-5494. DOI: 10.1016/j.tet.2013.04.087  1
2012 Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD. Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 55: 7759-71. PMID 22950983 DOI: 10.1021/jm3007917  1
2012 Lin CL, Kong Q, Cuny GD, Glicksman MA. Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Medicinal Chemistry. 4: 1689-700. PMID 22924507 DOI: 10.4155/fmc.12.122  1
2012 Abraham CR, Chen C, Cuny GD, Glicksman MA, Zeldich E. Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Medicinal Chemistry. 4: 1671-9. PMID 22924505 DOI: 10.4155/fmc.12.134  1
2012 Cuny GD. Foreword: neurodegenerative diseases: challenges and opportunities. Future Medicinal Chemistry. 4: 1647-9. PMID 22924500 DOI: 10.4155/fmc.12.123  1
2012 Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD. Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorganic & Medicinal Chemistry Letters. 22: 5685-8. PMID 22832318 DOI: 10.1016/j.bmcl.2012.06.098  1
2012 So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. American Journal of Neurodegenerative Disease. 1: 75-87. PMID 22822474  1
2012 Maki JL, Smith EE, Teng X, Ray SS, Cuny GD, Degterev A. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Analytical Biochemistry. 427: 164-74. PMID 22658960 DOI: 10.1016/j.ab.2012.05.019  1
2012 Wright PD, Wightman N, Huang M, Weiss A, Sapp PC, Cuny GD, Ivinson AJ, Glicksman MA, Ferrante RJ, Matson W, Matson S, Brown RH. A high-throughput screen to identify inhibitors of SOD1 transcription. Frontiers in Bioscience (Elite Edition). 4: 2801-8. PMID 22652679  1
2012 Hellal M, Singh S, Cuny GD. Synthesis of tetracyclic indoles via intramolecular α-arylation of ketones. The Journal of Organic Chemistry. 77: 4123-30. PMID 22480284 DOI: 10.1021/jo300052z  1
2012 Ezgimen M, Lai H, Mueller NH, Lee K, Cuny G, Ostrov DA, Padmanabhan R. Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. Antiviral Research. 94: 18-24. PMID 22343093 DOI: 10.1016/j.antiviral.2012.02.003  1
2012 Cuny GD, Ulyanova NP, Patnaik D, Liu JF, Lin X, Auerbach K, Ray SS, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2015-9. PMID 22335895 DOI: 10.1016/j.bmcl.2012.01.028  1
2012 Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD. Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorganic & Medicinal Chemistry Letters. 22: 1985-8. PMID 22310229 DOI: 10.1016/j.bmcl.2012.01.029  1
2012 Cherry JJ, Evans MC, Ni J, Cuny GD, Glicksman MA, Androphy EJ. Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay. Journal of Biomolecular Screening. 17: 481-95. PMID 22233647 DOI: 10.1177/1087057111431605  1
2012 Hart MJ, Glicksman M, Liu M, Sharma MK, Cuny G, Galvan V. Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein Analytical Biochemistry. 421: 467-476. PMID 22178911 DOI: 10.1016/j.ab.2011.11.020  1
2012 Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE. In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesthesia and Analgesia. 115: 297-304. PMID 21965364 DOI: 10.1213/ANE.0b013e3182320559  1
2012 King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, Robin M, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules that elevate Klotho expression. The Biochemical Journal. 441: 453-61. PMID 21939436 DOI: 10.1042/BJ20101909  1
2012 Hellal M, Singh S, Cuny GD. Monoligated Pd(0)-catalyzed intramolecular ortho- and para-arylation of phenols for the synthesis of aporphine alkaloids. Synthesis of (-)-lirinine Tetrahedron. 68: 1674-1681. DOI: 10.1016/j.tet.2011.12.022  1
2011 Liu M, Kang S, Ray S, Jackson J, Zaitsev AD, Gerber SA, Cuny GD, Glicksman MA. Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant. Biochemistry. 50: 9399-408. PMID 21961647 DOI: 10.1021/bi201173d  1
2011 Laha JK, Cuny GD. Synthesis of fused imidazoles, pyrroles, and indoles with a defined stereocenter α to nitrogen utilizing Mitsunobu alkylation followed by palladium-catalyzed cyclization. The Journal of Organic Chemistry. 76: 8477-82. PMID 21913645 DOI: 10.1021/jo201237h  1
2011 Xing X, Chang LC, Kong Q, Colton CK, Lai L, Glicksman MA, Lin CL, Cuny GD. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorganic & Medicinal Chemistry Letters. 21: 5774-7. PMID 21875806 DOI: 10.1016/j.bmcl.2011.08.009  1
2011 Laha JK, Barolo SM, Rossi RA, Cuny GD. Synthesis of carbolines by photostimulated cyclization of anilinohalopyridines. The Journal of Organic Chemistry. 76: 6421-5. PMID 21739958 DOI: 10.1021/jo200923n  1
2011 Shishova EY, Stoll JM, Ersoy BA, Shrestha S, Scapa EF, Li Y, Niepel MW, Su Y, Jelicks LA, Stahl GL, Glicksman MA, Gutierrez-Juarez R, Cuny GD, Cohen DE. Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology (Baltimore, Md.). 54: 664-74. PMID 21538437 DOI: 10.1002/hep.24393  1
2011 Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, et al. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 117: 4915-23. PMID 21393479 DOI: 10.1182/blood-2010-10-313064  1
2011 Laha JK, Zhang X, Qiao L, Liu M, Chatterjee S, Robinson S, Kosik KS, Cuny GD. Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 2098-101. PMID 21353545 DOI: 10.1016/j.bmcl.2011.01.140  1
2011 Hellal M, Cuny GD. Microwave assisted copper-free Sonogashira coupling/5-exo-dig cycloisomerization domino reaction: Access to 3-(phenylmethylene)isoindolin-1- ones and related heterocycles Tetrahedron Letters. 52: 5508-5511. DOI: 10.1016/j.tetlet.2011.08.070  1
2010 Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18: 382-95. PMID 20951947 DOI: 10.1016/j.ccr.2010.08.010  1
2010 Hellal M, Cuny GD. Synthesis of the indolizino[7,6-c]quinoline alkaloid isaindigotidione. Organic Letters. 12: 4628-31. PMID 20845915 DOI: 10.1021/ol101890t  1
2010 Cuny GD, Robin M, Ulyanova NP, Patnaik D, Pique V, Casano G, Liu JF, Lin X, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 3491-4. PMID 20836251 DOI: 10.1016/j.bmcl.2010.04.150  1
2010 Liu M, Poulose S, Schuman E, Zaitsev AD, Dobson B, Auerbach K, Seyb K, Cuny GD, Glicksman MA, Stein RL, Yue Z. Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors. Analytical Biochemistry. 404: 186-92. PMID 20566370 DOI: 10.1016/j.ab.2010.05.033  1
2010 Colton CK, Kong Q, Lai L, Zhu MX, Seyb KI, Cuny GD, Xian J, Glicksman MA, Lin CL. Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. Journal of Biomolecular Screening. 15: 653-62. PMID 20508255 DOI: 10.1177/1087057110370998  1
2010 Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, ... ... Cuny GD, et al. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One. 5: e10504. PMID 20498699 DOI: 10.1371/journal.pone.0010504  1
2010 Hellal M, Cuny GD. Intramolecular Aldol reaction of N-acylated (2-aminophenyl)-alpha-oxoacetic acids: rapid access to tri- and tetracyclic 1,2-dihydroquinolin-2(1H)-ones. The Journal of Organic Chemistry. 75: 3465-8. PMID 20394404 DOI: 10.1021/jo1003339  1
2010 Nowak RJ, Cuny GD, Choi S, Lansbury PT, Ray SS. Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods. Journal of Medicinal Chemistry. 53: 2709-18. PMID 20232802 DOI: 10.1021/jm901062p  1
2010 Ouertatani-Sakouhi H, Liu M, El-Turk F, Cuny GD, Glicksman MA, Lashuel HA. Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. Journal of Biomolecular Screening. 15: 347-58. PMID 20231420 DOI: 10.1177/1087057110363825  1
2010 Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE. Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 112: 637-44. PMID 20179500 DOI: 10.1097/ALN.0b013e3181cf40ed  1
2010 Lee K, Campbell J, Swoboda JG, Cuny GD, Walker S. Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus. Bioorganic & Medicinal Chemistry Letters. 20: 1767-70. PMID 20138521 DOI: 10.1016/j.bmcl.2010.01.036  1
2010 Macpherson IS, Kirubakaran S, Gorla SK, Riera TV, D'Aquino JA, Zhang M, Cuny GD, Hedstrom L. The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity. Journal of the American Chemical Society. 132: 1230-1. PMID 20052976 DOI: 10.1021/ja909947a  1
2010 Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. Journal of Neuroscience Research. 88: 1569-76. PMID 20025059 DOI: 10.1002/jnr.22314  1
2009 Qiao L, Choi S, Case A, Gainer TG, Seyb K, Glicksman MA, Lo DC, Stein RL, Cuny GD. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 6122-6. PMID 19783434 DOI: 10.1016/j.bmcl.2009.09.010  1
2009 Cuny GD. Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions. Current Pharmaceutical Design. 15: 3919-39. PMID 19751204 DOI: 10.2174/138161209789649330  1
2009 Maurya SK, Gollapalli DR, Kirubakaran S, Zhang M, Johnson CR, Benjamin NN, Hedstrom L, Cuny GD. Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 52: 4623-30. PMID 19624136 DOI: 10.1021/jm900410u  1
2009 Cuny GD. A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466. Expert Opinion On Therapeutic Patents. 19: 893-9. PMID 19473108 DOI: 10.1517/13543770902766829  1
2009 Call MJ, Xing X, Cuny GD, Seth NP, Altmann DM, Fugger L, Krogsgaard M, Stein RL, Wucherpfennig KW. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. Journal of Immunology (Baltimore, Md. : 1950). 182: 6342-52. PMID 19414787 DOI: 10.4049/jimmunol.0803464  1
2009 Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. Plos One. 4: e5274. PMID 19384407 DOI: 10.1371/journal.pone.0005274  1
2009 Laha JK, Petrou P, Cuny GD. One-pot synthesis of alpha-carbolines via sequential palladium-catalyzed aryl amination and intramolecular arylation. The Journal of Organic Chemistry. 74: 3152-5. PMID 19323545 DOI: 10.1021/jo802776m  1
2009 Wu J, Xing X, Cuny GD. Synthesis of Substituted Imidazo[1, 5-a]pyrimidines, 1H-pyrrolo[2, 3-b]pyridines and 3-methyl-3H-imidazo[4, 5-b]pyridines Letters in Organic Chemistry. 6: 203-207. DOI: 10.2174/157017809787893000  1
2008 Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nature Medicine. 14: 1363-9. PMID 19029982 DOI: 10.1038/nm.1888  1
2008 Patnaik D, Jun Xian, Glicksman MA, Cuny GD, Stein RL, Higgins JM. Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay. Journal of Biomolecular Screening. 13: 1025-34. PMID 18978305 DOI: 10.1177/1087057108326081  1
2008 Wagle N, Xian J, Shishova EY, Wei J, Glicksman MA, Cuny GD, Stein RL, Cohen DE. Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Analytical Biochemistry. 383: 85-92. PMID 18762160 DOI: 10.1016/j.ab.2008.07.039  1
2008 Liu M, Choi S, Cuny GD, Ding K, Dobson BC, Glicksman MA, Auerbach K, Stein RL. Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. Biochemistry. 47: 8367-77. PMID 18636751 DOI: 10.1021/bi800732v  1
2008 Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, Deng DY, Sachidanandan C, Bloch KD, Peterson RT. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 4388-92. PMID 18621530 DOI: 10.1016/j.bmcl.2008.06.052  1
2008 You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1564-73. PMID 18493258 DOI: 10.1038/jcbfm.2008.44  1
2008 Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 3219-23. PMID 18467094 DOI: 10.1016/j.bmcl.2008.04.048  1
2008 Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology. 4: 313-21. PMID 18408713 DOI: 10.1038/nchembio.83  1
2008 Cuny GD, Degterev A, Yuan J. Necroptosis - A novel cell death mechanism Drugs of the Future. 33: 225-233. DOI: 10.1358/dof.2008.033.03.1173882  1
2008 Laha JK, Cuny GD. Synthesis of tetrazolo[1,5-a]pyridines utilizing trimethylsilyl azide and tetrabutylammonium fluoride hydrate Synthesis. 4002-4006. DOI: 10.1055/s-0028-1083233  1
2007 Glicksman MA, Cuny GD, Liu M, Dobson B, Auerbach K, Stein RL, Kosik KS. New approaches to the discovery of cdk5 inhibitors. Current Alzheimer Research. 4: 547-9. PMID 18220519 DOI: 10.2174/156720507783018181  1
2007 Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 6836-40. PMID 17964153 DOI: 10.1016/j.bmcl.2007.10.024  1
2007 Mermerian AH, Case A, Stein RL, Cuny GD. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 3729-32. PMID 17449248 DOI: 10.1016/j.bmcl.2007.04.027  1
2007 Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. Journal of Medicinal Chemistry. 50: 1886-95. PMID 17361994 DOI: 10.1021/jm061016o  1
2006 Barolo SM, Teng X, Cuny GD, Rossi RA. Syntheses of aporphine and homoaporphine alkaloids by intramolecular ortho-arylation of phenols with aryl halides via SRN1 reactions in liquid ammonia. The Journal of Organic Chemistry. 71: 8493-9. PMID 17064025 DOI: 10.1021/jo061478+  1
2006 Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Current Alzheimer Research. 3: 221-7. PMID 16842099 DOI: 10.2174/156720506777632835  1
2006 Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW. Small molecules that enhance the catalytic efficiency of HLA-DM. Journal of Immunology (Baltimore, Md. : 1950). 176: 4208-20. PMID 16547258  1
2006 Zhang D, Xing X, Cuny GD. Synthesis of hydantoins from enantiomerically pure alpha-amino amides without epimerization. The Journal of Organic Chemistry. 71: 1750-3. PMID 16468841 DOI: 10.1021/jo052474s  1
2006 Cuny GD, Lee K, Choi S. Utilization of a tandem Michael-Dieckmann reaction to synthesize orixalone A Letters in Organic Chemistry. 3: 68-72. DOI: 10.2174/157017806774964378  1
2005 Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chemical Biology. 1: 112-9. PMID 16408008 DOI: 10.1038/nchembio711  1
2005 Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. Structure-activity relationship study of novel necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 5039-44. PMID 16153840 DOI: 10.1016/j.bmcl.2005.07.077  1
2005 Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chemistry & Biology. 12: 811-23. PMID 16039528 DOI: 10.1016/j.chembiol.2005.05.011  1
2005 Duval E, Case A, Stein RL, Cuny GD. Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 1885-9. PMID 15780627 DOI: 10.1016/j.bmcl.2005.02.005  1
2005 Yeh LA, Padmanaban D, Ho P, Xing X, Rowley P, Morse LJ, Jensen RV, Cuny GD. Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression. Bioorganic & Medicinal Chemistry Letters. 15: 1193-6. PMID 15686940 DOI: 10.1016/j.bmcl.2004.12.001  1
2004 Choi S, Haggart D, Toll L, Cuny GD. Synthesis, receptor binding and functional studies of mesoridazine stereoisomers. Bioorganic & Medicinal Chemistry Letters. 14: 4379-82. PMID 15357957 DOI: 10.1016/j.bmcl.2004.06.078  1
2004 Morse LJ, Payton SM, Cuny GD, Rogers JT. FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein. Journal of Molecular Neuroscience : Mn. 24: 129-36. PMID 15314261 DOI: 10.1385/JMN:24:1:129  1
2004 Duval E, Cuny GD. Synthesis of substituted carbazoles and β-carbolines by cyclization of diketoindole derivatives Tetrahedron Letters. 45: 5411-5413. DOI: 10.1016/j.tetlet.2004.05.053  1
2004 Cuny GD. Synthesis of (±)-aporphine utilizing Pictet-Spengler and intramolecular phenol ortho-arylation reactions Tetrahedron Letters. 45: 5167-5170. DOI: 10.1016/j.tetlet.2004.04.194  1
2003 Liu Y, Lashuel HA, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chemistry & Biology. 10: 837-46. PMID 14522054 DOI: 10.1016/j.chembiol.2003.08.010  1
2003 Oliva B, Miller K, Caggiano N, O'Neill AJ, Cuny GD, Hoemann MZ, Hauske JR, Chopra I. Biological properties of novel antistaphylococcal quinoline-indole agents. Antimicrobial Agents and Chemotherapy. 47: 458-66. PMID 12543644 DOI: 10.1128/AAC.47.2.458-466.2003  1
2003 Shao L, Cuny GD, Hauske JR, Staples RJ. (S)-N-(1-Phenylethylpiperidin-1-ium-3-ylmethyl)-N-phenylpropionamide trifluoroacetate Acta Crystallographica Section E: Structure Reports Online. 59: o1398-o1399. DOI: 10.1107/S1600536803015654  1
2003 Cuny GD. Intramolecular ortho-arylation of phenols utilized in the synthesis of the aporphine alkaloids (±)-lirinidine and (±)-nuciferine Tetrahedron Letters. 44: 8149-8152. DOI: 10.1016/j.tetlet.2003.09.026  1
2003 Xing X, Ho P, Bourquin G, Yeh LA, Cuny GD. Synthesis, stereochemistry confirmation and biological activity evaluation of a constituent from Isodon excisus Tetrahedron. 59: 9961-9969. DOI: 10.1016/j.tet.2003.10.025  1
2002 Hoemann MZ, Xie RL, Rossi RF, Meyer S, Sidhu A, Cuny GD, Hauske JR. Potent in vitro methicillin-resistant Staphylococcus aureus activity of 2-(1H-indol-3-yl)tetrahydroquinoline derivatives. Bioorganic & Medicinal Chemistry Letters. 12: 129-32. PMID 11755337 DOI: 10.1016/S0960-894X(01)00714-4  1
2002 Xing X, Padmanaban D, Yeh LA, Cuny GD. Utilization of a copper-catalyzed diaryl ether synthesis for the preparation of verbenachalcone Tetrahedron. 58: 7903-7910. DOI: 10.1016/S0040-4020(02)00915-8  1
2000 Hoemann MZ, Kumaravel G, Xie RL, Rossi RF, Meyer S, Sidhu A, Cuny GD, Hauske JR. Potent in vitro methicillin-resistant Staphylococcus aureus activity of 2-(1H-indol-3-yl)quinoline derivatives. Bioorganic & Medicinal Chemistry Letters. 10: 2675-8. PMID 11128649 DOI: 10.1016/S0960-894X(00)00542-4  1
1999 Cuny GD, Landgrebe KD, Smith TP, Fehr MJ, Petrich JW, Carpenter S. Photoactivated virucidal properties of tridentate 2,2'-dihydroxyazobenzene and 2-salicylideneaminophenol platinum pyridine complexes. Bioorganic & Medicinal Chemistry Letters. 9: 237-40. PMID 10021936 DOI: 10.1016/S0960-894X(98)00714-8  1
1999 Cuny GD, Cao J, Sidhu A, Hauske JR. Solution-phase ring opening cross-metathesis of bicyclic alkenes with styrene derivatives and its application to 'resin capture' solid-phase synthesis Tetrahedron. 55: 8169-8178. DOI: 10.1016/S0040-4020(99)00298-7  1
1998 Cuny GD, Hauske JR. Use ring - Opening cross-metathesis to construct molecular motifs Chemtech. 28: 25-31.  1
1997 Cao J, Cuny GD, Hauske JR. Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized cyclopentanes. Molecular Diversity. 3: 173-9. PMID 9680648 DOI: 10.1016/S0040-4039(97)01144-1  1
1995 Johnson JR, Cuny GD, Buchwald SL. Rhodium-catalyzed hydroformylation of internal alkynes to α,β-unsaturated aldehydes Angewandte Chemie (International Edition in English). 34: 1760-1761.  1
1991 Cuny GD, Gutiérrez A, Buchwald SL. Cis difunctionalization of cyclic olefins with use of organozirconium intermediates Organometallics. 10: 537-539.  1
1991 Cuny GD, Buchwald SL. Ring-opening reactions of cyclic allylic ethers by zirconocene complexes of cyclic alkynes Organometallics. 10: 363-365.  1
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