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Thomas Edward Wales - Publications

2006- Chemistry and Chemical Biology Northeastern University, Boston, MA, United States 
Bioanalytical Chemistry

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Engen JR, Botzanowski T, Peterle D, Georgescauld F, Wales TE. Developments in Hydrogen/Deuterium Exchange Mass Spectrometry. Analytical Chemistry. PMID 33112590 DOI: 10.1021/acs.analchem.0c04281  1
2020 Staudt RP, Alvarado JJ, Emert-Sedlak LA, Shi H, Shu ST, Wales TE, Engen JR, Smithgall TE. Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes. The Journal of Biological Chemistry. PMID 32862141 DOI: 10.1074/jbc.REV120.012317  1
2020 Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nature Chemical Biology. PMID 32807965 DOI: 10.1038/s41589-020-0625-7  1
2020 Vetter CJ, Thorn DC, Wheeler SG, Mundorff C, Halverson K, Wales TE, Shinde U, Engen JR, David LL, Carver JA, Lampi KJ. Cumulative deamidations of the major lens protein γS-crystallin increase its aggregation during unfolding and oxidation. Protein Science : a Publication of the Protein Society. PMID 32697405 DOI: 10.1002/pro.3915  1
2020 Korshavn KJ, Wales TE, Bird GH, Engen JR, Walensky LD. A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nature Structural & Molecular Biology. PMID 32661419 DOI: 10.1038/s41594-020-0458-9  1
2020 Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, et al. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Molecular Cell. PMID 32533918 DOI: 10.1016/j.molcel.2020.05.029  1
2020 Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, et al. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology. PMID 32413285 DOI: 10.1016/j.chembiol.2020.04.004  1
2020 Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD. Identification of a Structural Determinant for Selective Targeting of HDMX. Structure (London, England : 1993). PMID 32359398 DOI: 10.1016/j.str.2020.04.011  1
2020 Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD. Hydrocarbon-stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor. Acs Chemical Biology. PMID 32348108 DOI: 10.1021/acschembio.0c00308  1
2020 Cohen DT, Wales TE, McHenry MW, Engen JR, Walensky LD. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX. Cell Reports. 30: 3229-3239.e6. PMID 32160532 DOI: 10.1016/j.celrep.2020.02.057  1
2020 Fleischhacker AS, Gunawan AL, Kochert BA, Liu L, Wales TE, Borowy MC, Engen JR, Ragsdale SW. The heme regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation. The Journal of Biological Chemistry. PMID 32152224 DOI: 10.1074/jbc.RA120.012803  1
2020 Frame NM, Kumanan M, Wales TE, Bandara A, Fändrich M, Straub JE, Engen JR, Gursky O. Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A. Journal of Molecular Biology. PMID 32035904 DOI: 10.1016/j.jmb.2020.01.029  1
2020 Eggertson MJ, Fadgen K, Engen JR, Wales TE. Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data. Methods in Molecular Biology (Clifton, N.J.). 2051: 407-435. PMID 31552640 DOI: 10.1007/978-1-4939-9744-2_18  1
2019 Amatya N, Wales TE, Kwon A, Yeung W, Joseph RE, Fulton DB, Kannan N, Engen JR, Andreotti AH. Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591208 DOI: 10.1073/pnas.1907566116  1
2019 Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD. Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. Nature Biotechnology. PMID 31427820 DOI: 10.1038/s41587-019-0222-z  1
2019 Bera AK, Lu J, Wales TE, Gondi S, Gurbani D, Nelson A, Engen JR, Westover KD. Structural basis of the atypical activation mechanism of KRAS V14I. The Journal of Biological Chemistry. PMID 31341022 DOI: 10.1074/jbc.RA119.009131  1
2019 Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, ... ... Wales TE, et al. Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Nature Methods. 16: 595-602. PMID 31249422 DOI: 10.1038/s41592-019-0459-y  1
2019 Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science (New York, N.Y.). PMID 31249135 DOI: 10.1126/science.aax1033  1
2019 Georgescauld F, Wales TE, Engen JR. Hydrogen deuterium exchange mass spectrometry applied to chaperones and chaperone-assisted protein folding. Expert Review of Proteomics. 1-13. PMID 31215268 DOI: 10.1080/14789450.2019.1633920  1
2019 Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, ... ... Wales TE, et al. Tissue-specific oncogenic activity of K-RasA146T. Cancer Discovery. PMID 30952657 DOI: 10.1158/2159-8290.CD-18-1220  1
2019 Kochert BA, Fleischhacker AS, Wales TE, Becker DF, Engen JR, Ragsdale SW. Dynamic and structural differences between heme oxygenase-1 and -2 are due to differences in their C-terminal regions. The Journal of Biological Chemistry. PMID 30944174 DOI: 10.1074/jbc.RA119.008592  1
2019 Dautant A, Henri J, Wales TE, Meyer P, Engen JR, Georgescauld F. Remodeling of the binding site of nucleoside diphosphate kinase revealed by X-Ray structure and H/D exchange. Biochemistry. PMID 30785730 DOI: 10.1021/acs.biochem.8b01308  1
2018 Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA. Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. Nature Structural & Molecular Biology. PMID 29967539 DOI: 10.1038/s41594-018-0085-x  1
2018 de Wispelaere M, Lian W, Potisopon S, Li PC, Jang J, Ficarro SB, Clark MJ, Zhu X, Kaplan JB, Pitts JD, Wales TE, Wang J, Engen JR, Marto JA, Gray NS, et al. Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chemical Biology. PMID 29937406 DOI: 10.1016/j.chembiol.2018.05.011  1
2018 Kochert BA, Iacob RE, Wales TE, Makriyannis A, Engen JR. Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes. Methods in Molecular Biology (Clifton, N.J.). 1764: 153-171. PMID 29605914 DOI: 10.1007/978-1-4939-7759-8_10  1
2018 Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, et al. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Molecular Cell. 69: 729-743.e7. PMID 29499131 DOI: 10.1016/j.molcel.2018.02.005  1
2017 Moroco JA, Alvarado JJ, Staudt RP, Shic H, Wales TE, Smithgall TE, Engen JR. Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding. Journal of Molecular Biology. PMID 29258818 DOI: 10.1016/j.jmb.2017.12.008  1
2017 Joseph RE, Wales TE, Fulton DB, Engen JR, Andreotti AH. Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts. Structure (London, England : 1993). PMID 28867612 DOI: 10.1016/j.str.2017.07.014  1
2017 Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD. Allosteric sensitization of proapoptotic BAX. Nature Chemical Biology. PMID 28692068 DOI: 10.1038/nchembio.2433  1
2017 Wales TE, Fadgen KE, Eggertson MJ, Engen JR. Subzero Celsius separations in three-zone temperature controlled hydrogen deuterium exchange mass spectrometry. Journal of Chromatography. A. PMID 28596009 DOI: 10.1016/j.chroma.2017.05.067  1
2016 Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic? Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-2. PMID 28042708 DOI: 10.1080/13506129.2016.1269737  1
2016 Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD. Allosteric inhibition of antiapoptotic MCL-1. Nature Structural & Molecular Biology. PMID 27159560 DOI: 10.1038/nsmb.3223  1
2016 Wales TE, Poe JA, Emert-Sedlak L, Morgan CR, Smithgall TE, Engen JR. Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants. Journal of the American Society For Mass Spectrometry. PMID 27032648 DOI: 10.1007/s13361-016-1365-5  1
2016 Chopra N, Wales TE, Joseph RE, Boyken SE, Engen JR, Jernigan RL, Andreotti AH. Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases. Plos Computational Biology. 12: e1004826. PMID 27010561 DOI: 10.1371/journal.pcbi.1004826  1
2016 Guttman M, Wales TE, Whittington D, Engen JR, Brown JM, Lee KK. Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis. Journal of the American Society For Mass Spectrometry. PMID 26810432 DOI: 10.1007/s13361-015-1330-8  1
2016 Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE. Dynamics of the Tec-family Tyrosine Kinase SH3 domains. Protein Science : a Publication of the Protein Society. PMID 26808198 DOI: 10.1002/pro.2887  1
2015 Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic? Journal of Molecular Biology. PMID 26562506 DOI: 10.1016/j.jmb.2015.10.029  1
2015 Wales TE, Hochrein JM, Morgan CR, Emert-Sedlak LA, Smithgall TE, Engen JR. Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor. Biochemistry. 54: 6382-91. PMID 26440750 DOI: 10.1021/acs.biochem.5b00875  1
2015 Pirrone GF, Emert-Sedlak LA, Wales TE, Smithgall TE, Kent MS, Engen JR. Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer. Analytical Chemistry. PMID 26133569 DOI: 10.1021/acs.analchem.5b01725  1
2015 Engen JR, Wales TE. Analytical Aspects of Hydrogen Exchange Mass Spectrometry. Annual Review of Analytical Chemistry (Palo Alto, Calif.). PMID 26048552 DOI: 10.1146/annurev-anchem-062011-143113  1
2015 Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD. Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Molecular Cell. 57: 873-86. PMID 25684204 DOI: 10.1016/j.molcel.2015.01.014  1
2014 Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH. A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. Journal of Molecular Biology. 426: 3656-69. PMID 25193673 DOI: 10.1016/j.jmb.2014.08.018  1
2014 Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE. Differential sensitivity of Src-family kinases to activation by SH3 domain displacement. Plos One. 9: e105629. PMID 25144189 DOI: 10.1371/journal.pone.0105629  1
2013 Shi XE, Wales TE, Elkin C, Kawahata N, Engen JR, Annis DA. Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties. Analytical Chemistry. 85: 11185-8. PMID 24215480 DOI: 10.1021/ac403173p  1
2013 Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH. Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Science Signaling. 6: ra76. PMID 23982207 DOI: 10.1126/scisignal.2004298  1
2013 Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A. Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study. Biochemistry. 52: 5016-26. PMID 23795559 DOI: 10.1021/bi400430k  1
2013 Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC. Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. Journal of Molecular Biology. 425: 3192-204. PMID 23747483 DOI: 10.1016/j.jmb.2013.05.025  1
2013 Tsukamoto K, Wales TE, Daniels K, Pal R, Sheng R, Cho W, Stafford W, Engen JR, Krieger M, Kocher O. Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI). The Journal of Biological Chemistry. 288: 19845-60. PMID 23720744 DOI: 10.1074/jbc.M113.460170  1
2013 Engen JR, Wales TE, Chen S, Marzluff EM, Hassell KM, Weis DD, Smithgall TE. Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry. International Reviews in Physical Chemistry. 32: 96-127. PMID 23682200 DOI: 10.1080/0144235X.2012.751175  1
2013 Wales TE, Eggertson MJ, Engen JR. Considerations in the analysis of hydrogen exchange mass spectrometry data. Methods in Molecular Biology (Clifton, N.J.). 1007: 263-88. PMID 23666730 DOI: 10.1007/978-1-62703-392-3_11  1
2013 Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A. Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Science : a Publication of the Protein Society. 22: 774-87. PMID 23553709 DOI: 10.1002/pro.2257  1
2013 Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE. Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. The Journal of Biological Chemistry. 288: 6116-29. PMID 23303187 DOI: 10.1074/jbc.M112.431312  1
2012 Karageorgos I, Zvonok N, Janero DR, Vemuri VK, Shukla V, Wales TE, Engen JR, Makriyannis A. Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL). Acs Chemical Neuroscience. 3: 393-9. PMID 22860208 DOI: 10.1021/cn3000263  1
2012 Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE. HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck. Bmc Chemical Biology. 12: 1. PMID 22420777 DOI: 10.1186/1472-6769-12-1  1
2012 Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC. Conformational locking upon cooperative assembly of notch transcription complexes. Structure (London, England : 1993). 20: 340-9. PMID 22325781 DOI: 10.1016/j.str.2011.12.011  1
2011 Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC. Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (London, England : 1993). 19: 546-54. PMID 21481777 DOI: 10.1016/j.str.2011.01.016  1
2010 Fang J, Rand KD, Silva MC, Wales TE, Engen JR, Beuning PJ. Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'. Journal of Molecular Biology. 398: 40-53. PMID 20206636 DOI: 10.1016/j.jmb.2010.02.040  1
2008 Wales TE, Fadgen KE, Gerhardt GC, Engen JR. High-speed and high-resolution UPLC separation at zero degrees Celsius. Analytical Chemistry. 80: 6815-20. PMID 18672890 DOI: 10.1021/ac8008862  1
2008 Engen JR, Wales TE, Hochrein JM, Meyn MA, Banu Ozkan S, Bahar I, Smithgall TE. Structure and dynamic regulation of Src-family kinases. Cellular and Molecular Life Sciences : Cmls. 65: 3058-73. PMID 18563293 DOI: 10.1007/s00018-008-8122-2  1
2007 Trible RP, Emert-Sedlak L, Wales TE, Ayyavoo V, Engen JR, Smithgall TE. Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor. Journal of Molecular Biology. 374: 121-9. PMID 17920628 DOI: 10.1016/j.jmb.2007.09.009  1
2006 Weis DD, Wales TE, Engen JR, Hotchko M, Ten Eyck LF. Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis. Journal of the American Society For Mass Spectrometry. 17: 1498-509. PMID 16875839 DOI: 10.1016/j.jasms.2006.05.014  1
2006 Hochrein JM, Wales TE, Lerner EC, Schiavone AP, Smithgall TE, Engen JR. Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry. Biochemistry. 45: 7733-9. PMID 16784224 DOI: 10.1021/bi060438x  1
2006 Wales TE, Engen JR. Partial unfolding of diverse SH3 domains on a wide timescale. Journal of Molecular Biology. 357: 1592-604. PMID 16487539 DOI: 10.1016/j.jmb.2006.01.075  1
2006 Wang M, Wales TE, Fitzgerald MC. Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold. Proceedings of the National Academy of Sciences of the United States of America. 103: 2600-4. PMID 16473949 DOI: 10.1073/pnas.0508121103  1
2006 Wales TE, Engen JR. Hydrogen exchange mass spectrometry for the analysis of protein dynamics. Mass Spectrometry Reviews. 25: 158-70. PMID 16208684 DOI: 10.1002/mas.20064  1
2004 Wales TE, Richardson JS, Fitzgerald MC. Facile chemical synthesis and equilibrium unfolding properties of CopG. Protein Science : a Publication of the Protein Society. 13: 1918-26. PMID 15169951 DOI: 10.1110/ps.04671804  1
2003 Powell KD, Wang MZ, Silinski P, Ma L, Wales TE, Dai SY, Warner AH, Yang X, Fitzgerald MC. The accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic stability of proteins Analytica Chimica Acta. 496: 225-232. DOI: 10.1016/S0003-2670(03)01002-X  1
2002 Powell KD, Wales TE, Fitzgerald MC. Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method. Protein Science : a Publication of the Protein Society. 11: 841-51. PMID 11910027 DOI: 10.1110/ps.3820102  1
2001 Wales TE, Fitzgerald MC. The energetic contribution of backbone--backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant. Journal of the American Chemical Society. 123: 7709-10. PMID 11480998 DOI: 10.1021/ja010775n  1
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