Gary Loren Kleiger - Publications

Affiliations: 
2002 University of California, Los Angeles, Los Angeles, CA 

13/26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Sandoval D, Hill S, Ziemba A, Lewis S, Kuhlman B, Kleiger G. Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations. The Journal of Biological Chemistry. 290: 1106-18. PMID 25425648 DOI: 10.1074/Jbc.M114.615559  0.36
2014 Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F. E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nature Chemical Biology. 10: 156-163. PMID 24316736 DOI: 10.1038/Nchembio.1412  0.36
2013 Ziemba A, Hill S, Sandoval D, Webb K, Bennett EJ, Kleiger G. Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails. The Journal of Biological Chemistry. 288: 34882-96. PMID 24129577 DOI: 10.1074/Jbc.M113.509190  0.36
2012 den Besten W, Verma R, Kleiger G, Oania RS, Deshaies RJ. NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nature Structural & Molecular Biology. 19: 511-6, S1. PMID 22466964 DOI: 10.1038/Nsmb.2269  0.36
2011 Saha A, Lewis S, Kleiger G, Kuhlman B, Deshaies RJ. Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate. Molecular Cell. 42: 75-83. PMID 21474069 DOI: 10.1016/J.Molcel.2011.03.016  0.36
2010 Tyrrell A, Flick K, Kleiger G, Zhang H, Deshaies RJ, Kaiser P. Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins. Proceedings of the National Academy of Sciences of the United States of America. 107: 19796-801. PMID 21041680 DOI: 10.1073/Pnas.1010648107  0.36
2009 Pierce NW, Kleiger G, Shan SO, Deshaies RJ. Detection of sequential polyubiquitylation on a millisecond timescale. Nature. 462: 615-9. PMID 19956254 DOI: 10.1038/Nature08595  0.36
2009 Kleiger G, Saha A, Lewis S, Kuhlman B, Deshaies RJ. Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell. 139: 957-68. PMID 19945379 DOI: 10.1016/J.Cell.2009.10.030  0.36
2006 Petroski MD, Kleiger G, Deshaies RJ. Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex. Molecular Cell. 24: 523-34. PMID 17114057 DOI: 10.1016/J.Molcel.2006.10.010  0.36
2003 McCarty AS, Kleiger G, Eisenberg D, Smale ST. Selective dimerization of a C2H2 zinc finger subfamily. Molecular Cell. 11: 459-70. PMID 12620233 DOI: 10.1016/S1097-2765(03)00043-1  0.36
2002 Kleiger G, Eisenberg D. GXXXG and GXXXA motifs stabilize FAD and NAD(P)-binding Rossmann folds through C(alpha)-H... O hydrogen bonds and van der waals interactions. Journal of Molecular Biology. 323: 69-76. PMID 12368099 DOI: 10.1016/S0022-2836(02)00885-9  0.64
2000 Cobb BS, Morales-Alcelay S, Kleiger G, Brown KE, Fisher AG, Smale ST. Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. Genes & Development. 14: 2146-60. PMID 10970879 DOI: 10.1101/Gad.816400  0.36
2000 Kleiger G, Beamer LJ, Grothe R, Mallick P, Eisenberg D. The 1.7 A crystal structure of BPI: a study of how two dissimilar amino acid sequences can adopt the same fold. Journal of Molecular Biology. 299: 1019-34. PMID 10843855 DOI: 10.1006/Jmbi.2000.3805  0.56
Low-probability matches
2014 Kleiger G, Mayor T. Perilous journey: a tour of the ubiquitin–proteasome system Trends in Cell Biology. 24: 352-359. PMID 24457024 DOI: 10.1016/J.Tcb.2013.12.003  0.2
2020 Baek K, Krist DT, Prabu JR, Hill S, Klügel M, Neumaier LM, von Gronau S, Kleiger G, Schulman BA. NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature. PMID 32051583 DOI: 10.1038/S41586-020-2000-Y  0.01
2019 Hill S, Reichermeier K, Scott DC, Samentar L, Coulombe-Huntington J, Izzi L, Tang X, Ibarra R, Bertomeu T, Moradian A, Sweredoski MJ, Caberoy N, Schulman BA, Sicheri F, Tyers M, ... Kleiger G, et al. Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways. Elife. 8. PMID 31868589 DOI: 10.7554/Elife.51163  0.04
2019 Jones RD, Enam C, Ibarra R, Borror HR, Mostoller KE, Fredrickson EK, Lin J, Chuang E, March Z, Shorter J, Ravid T, Kleiger G, Gardner RG. The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate. Molecular Biology of the Cell. mbcE18020121. PMID 31825716 DOI: 10.1091/Mbc.E18-02-0121  0.01
2019 Hill S, Reichermeier K, Scott DC, Samentar L, Coulombe-Huntington J, Izzi L, Tang X, Ibarra R, Bertomeu T, Moradian A, Sweredoski MJ, Caberoy N, Schulman BA, Sicheri F, Tyers M, ... Kleiger G, et al. Author response: Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways Elife. DOI: 10.7554/Elife.51163.Sa2  0.04
2017 Hill S, Kleiger G. Self-regulating ubiquitin ligases. The Embo Journal. PMID 28087580 DOI: 10.15252/Embj.201696154  0.12
2016 Kleiger G, Deshaies R. Tag Team Ubiquitin Ligases. Cell. 166: 1080-1. PMID 27565338 DOI: 10.1016/J.Cell.2016.08.014  0.08
2016 Ibarra R, Sandoval D, Fredrickson EK, Gardner RG, Kleiger G. The San1 ubiquitin ligase functions preferentially with ubiquitin-conjugating enzyme Ubc1 during protein quality control. The Journal of Biological Chemistry. PMID 27405755 DOI: 10.1074/Jbc.M116.737619  0.01
2016 Hill S, Harrison JS, Lewis SM, Kuhlman B, Kleiger G. Mechanism of Lysine 48 selectivity during poly-ubiquitin chain formation by the Ube2R1/2 ubiquitin-conjugating enzyme. Molecular and Cellular Biology. PMID 27044868 DOI: 10.1128/Mcb.00097-16  0.12
2009 Kleiger G, Hao B, Mohl DA, Deshaies RJ. The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCFCdc4. The Journal of Biological Chemistry. 284: 36012-23. PMID 19875449 DOI: 10.1074/Jbc.M109.058529  0.12
2004 Kleiger G, Panina EM, Mallick P, Eisenberg D. PFIT and PFRIT: bioinformatic algorithms for detecting glycosidase function from structure and sequence. Protein Science : a Publication of the Protein Society. 13: 221-9. PMID 14691237 DOI: 10.1110/Ps.03274104  0.52
2002 Kleiger G, Grothe R, Mallick P, Eisenberg D. GXXXG and AXXXA: Common α-Helical Interaction Motifs in Proteins, Particularly in Extremophiles† Biochemistry. 41: 5990-5997. PMID 11993993 DOI: 10.1021/Bi0200763  0.52
2001 Kleiger G, Perry J, Eisenberg D. 3D structure and significance of the GPhiXXG helix packing motif in tetramers of the E1beta subunit of pyruvate dehydrogenase from the archeon Pyrobaculum aerophilum. Biochemistry. 40: 14484-14492. PMID 11724561 DOI: 10.1021/Bi011016K  0.52
Hide low-probability matches.