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Wen-Lian Wu - Publications

Affiliations: 
Chemistry Ohio State University, Columbus, Columbus, OH 
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Wu WL, Burnett DA, Clader J, Greenlee WJ, Jiang Q, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, Terracina G, Zhang Q, Nomeir A, Parker EM, Zhang L. Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27836402 DOI: 10.1016/j.bmcl.2016.04.095  0.583
2016 Pissarnitski DA, Zhao Z, Cole D, Wu WL, Domalski M, Clader JW, Scapin G, Voigt J, Soriano A, Kelly T, Powles MA, Yao Z, Burnett DA. Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors. Bioorganic & Medicinal Chemistry. PMID 27670099 DOI: 10.1016/j.bmc.2016.09.007  0.591
2016 Wu WL, Hao J, Domalski M, Burnett DA, Pissarnitski D, Zhao Z, Stamford A, Scapin G, Gao YD, Soriano A, Kelly TM, Yao Z, Powles MA, Chen S, Mei H, et al. Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. Acs Medicinal Chemistry Letters. 7: 498-501. PMID 27190600 DOI: 10.1021/acsmedchemlett.6b00027  0.63
2015 Zhao Z, Pissarnitski DA, Josien H, Wu WL, Xu R, Li H, Clader J, Burnett DA, Terracina G, Hyde L, Lee J, Song L, Zhang L. Discovery of a novel, potent spirocyclic series of γ-secretase inhibitors. Journal of Medicinal Chemistry. PMID 26496070 DOI: 10.1021/acs.jmedchem.5b00774  0.627
2013 Wu WL, Sasikumar TK, Domalski MS, Qiang L, Burnett DA, Clader J, Greenlee WJ, Chan TM, Lee J, Zhang L. A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 850-3. PMID 23265902 DOI: 10.1016/j.bmcl.2012.11.054  0.594
2013 Wu WL, Asberom T, Bara T, Bennett C, Burnett DA, Clader J, Domalski M, Greenlee WJ, Josien H, McBriar M, Rajagopalan M, Vicarel M, Xu R, Hyde LA, Del Vecchio RA, et al. Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 844-9. PMID 23265892 DOI: 10.1016/j.bmcl.2012.11.047  0.621
2012 Wu WL, Domalski M, Burnett DA, Josien H, Bara T, Rajagopalan M, Xu R, Clader J, Greenlee WJ, Brunskill A, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, et al. Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease. Acs Medicinal Chemistry Letters. 3: 892-6. PMID 24900404 DOI: 10.1021/ml300044f  0.619
2012 Brumfield S, Korakas P, Silverman LS, Tulshian D, Matasi JJ, Qiang L, Bennett CE, Burnett DA, Greenlee WJ, Knutson CE, Wu WL, Sasikumar TK, Domalski M, Bertorelli R, Grilli M, et al. Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain. Bioorganic & Medicinal Chemistry Letters. 22: 7223-6. PMID 23084894 DOI: 10.1016/J.Bmcl.2012.09.048  0.585
2012 Bennett CE, Burnett DA, Greenlee WJ, Knutson CE, Korakas P, Li C, Tulshian D, Wu WL, Bertorelli R, Fredduzzi S, Grilli M, Lozza G, Reggiani A, Veltri A. Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain. Bioorganic & Medicinal Chemistry Letters. 22: 1575-8. PMID 22266036 DOI: 10.1016/J.Bmcl.2011.12.131  0.586
2011 Xu R, Cole D, Asberom T, Bara T, Bennett C, Burnett DA, Clader J, Domalski M, Greenlee WJ, Hyde L, Josien H, Li H, McBriar M, McKittrick B, Pissarnitski D, ... ... Wu WL, et al. SAR of tricyclic sulfones as γ-secretase inhibitors Science China Chemistry. 54: 1688-1701. DOI: 10.1007/s11426-011-4388-6  0.589
2010 Sasikumar TK, Burnett DA, Asberom T, Wu WL, Bennett C, Cole D, Xu R, Greenlee WJ, Clader J, Zhang L, Hyde L. Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies. Bioorganic & Medicinal Chemistry Letters. 20: 3645-8. PMID 20471254 DOI: 10.1016/j.bmcl.2010.04.103  0.628
2010 Xu R, Cole D, Asberom T, Bara T, Bennett C, Burnett DA, Clader J, Domalski M, Greenlee W, Hyde L, Josien H, Li H, McBriar M, McKittrick B, McPhail AT, ... ... Wu WL, et al. Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity. Bioorganic & Medicinal Chemistry Letters. 20: 2591-6. PMID 20236824 DOI: 10.1016/j.bmcl.2010.02.080  0.634
2007 Wu WL, Burnett DA, Domalski M, Greenlee WJ, Li C, Bertorelli R, Fredduzzi S, Lozza G, Veltri A, Reggiani A. Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain. Journal of Medicinal Chemistry. 50: 5550-3. PMID 17929793 DOI: 10.1021/jm070590c  0.528
2006 Sasikumar TK, Qiang L, Wu WL, Burnett DA, Greenlee WJ, O'Neill K, Hawes BE, van Heek M, Graziano M. Tetrahydroisoquinolines as MCH-R1 antagonists. Bioorganic & Medicinal Chemistry Letters. 16: 4917-21. PMID 16824753 DOI: 10.1016/j.bmcl.2006.06.055  0.596
2006 Wu WL, Burnett DA, Caplen MA, Domalski MS, Bennett C, Greenlee WJ, Hawes BE, O'Neill K, Weig B, Weston D, Spar B, Kowalski T. Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorganic & Medicinal Chemistry Letters. 16: 3674-8. PMID 16690315 DOI: 10.1016/j.bmcl.2006.04.062  0.612
2006 Wu WL, Burnett DA, Spring R, Qiang L, Sasikumar TK, Domalski MS, Greenlee WJ, O'Neill K, Hawes BE. Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists. Bioorganic & Medicinal Chemistry Letters. 16: 3668-73. PMID 16690312 DOI: 10.1016/j.bmcl.2006.04.061  0.616
2005 Wu WL, Burnett DA, Spring R, Greenlee WJ, Smith M, Favreau L, Fawzi A, Zhang H, Lachowicz JE. Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists. Journal of Medicinal Chemistry. 48: 680-93. PMID 15689153 DOI: 10.1021/jm030614p  0.565
2002 Wu WL, Caplen MA, Domalski MS, Zhang H, Fawzi A, Burnett DA. Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 12: 3157-60. PMID 12372523 DOI: 10.1016/S0960-894X(02)00652-2  0.562
1998 Gao Y, Wu WL, Wu YL, Ye B, Zhou R. A straightforward synthetic approach to the spiroketal-enol ethers synthesis of natural antifeeding compound tonghaosu and its analogs Tetrahedron. 54: 12523-12538.  0.301
1997 Hart DJ, Li J, Wu WL, Kozikowski AP. Applications of organosulfur chemistry to organic synthesis: Total synthesis of (+)-himbeline and (+)-himbacine Journal of Organic Chemistry. 62: 5023-5033. DOI: 10.1021/Jo970612A  0.478
1996 Hart DJ, Wu WL. Observations regarding the first step of the Julia-Lythgoe olefin synthesis Tetrahedron Letters. 37: 5283-5286. DOI: 10.1016/0040-4039(96)01092-1  0.473
1995 Hart DJ, Wu WL, Kozikowski AP. Total syntheses of (+)-himbacine and (+)-himbeline Journal of the American Chemical Society. 117: 9369-9370. DOI: 10.1021/Ja00141A036  0.465
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