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Clark Sehon - Publications

Affiliations: 
1997 University of Virginia, Charlottesville, VA 
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Harris PA, Faucher N, George N, Eidam PM, King BW, White G, Anderson NA, Bandyopadhyay D, Beal AM, Beneton V, Berger SB, Campobasso N, Campos S, Capriotti CA, Cox JA, ... ... Sehon CA, et al. Discovery and Lead-optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. Journal of Medicinal Chemistry. PMID 31013427 DOI: 10.1021/Acs.Jmedchem.9B00318  0.673
2017 Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, ... ... Sehon CA, et al. Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. Journal of Medicinal Chemistry. PMID 28151659 DOI: 10.1021/Acs.Jmedchem.6B01751  0.693
2014 Mandal P, Berger SB, Pillay S, Moriwaki K, Huang C, Guo H, Lich JD, Finger J, Kasparcova V, Votta B, Ouellette M, King BW, Wisnoski D, Lakdawala AS, DeMartino MP, ... ... Sehon CA, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Molecular Cell. 56: 481-95. PMID 25459880 DOI: 10.1016/J.Molcel.2014.10.021  0.365
2014 Rickard DJ, Sehon CA, Kasparcova V, Kallal LA, Haile PA, Zeng X, Montoute MN, Poore DD, Li H, Wu Z, Eidam PM, Emery JG, Marquis RW, Gough PJ, Bertin J. Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway. Plos One. 9: e96737. PMID 24806487 DOI: 10.1371/journal.pone.0096737  0.706
2013 Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, Sehon CA, Marquis RW, Bertin J, Mocarski ES. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. The Journal of Biological Chemistry. 288: 31268-79. PMID 24019532 DOI: 10.1074/Jbc.M113.462341  0.364
2013 Rickard DJ, Sehon CA, Kasparcova V, Kallal LA, Zeng X, Montoute MN, Chordia T, Poore DD, Li H, Wu Z, Eidam PM, Haile PA, Yu J, Emery JG, Marquis RW, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. Plos One. 8: e69619. PMID 23936340 DOI: 10.1371/Journal.Pone.0069619  0.7
2012 Gatheral T, Reed DM, Moreno L, Gough PJ, Votta BJ, Sehon CA, Rickard DJ, Bertin J, Lim E, Nicholson AG, Mitchell JA. A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses. Plos One. 7: e42386. PMID 22870324 DOI: 10.1371/journal.pone.0042386  0.305
2011 Wang GZ, Haile PA, Daniel T, Belot B, Viet AQ, Goodman KB, Sha D, Dowdell SE, Varga N, Hong X, Chakravorty S, Webb C, Cornejo C, Olzinski A, Bernard R, ... ... Sehon CA, et al. CCR2 receptor antagonists: optimization of biaryl sulfonamides to increase activity in whole blood. Bioorganic & Medicinal Chemistry Letters. 21: 7291-4. PMID 22047688 DOI: 10.1016/j.bmcl.2011.10.038  0.336
2010 Mapes CM, Mani NS, Deng X, Pandit CR, McClure KJ, Pippel MC, Sehon CA, Gomez L, Shinde S, Breitenbucher JG, Jones TK. Practical and scalable synthesis of a selective CCK1 receptor antagonist. The Journal of Organic Chemistry. 75: 7950-3. PMID 20977279 DOI: 10.1021/jo1017684  0.311
2010 Behm DJ, Aiyar NV, Olzinski AR, McAtee JJ, Hilfiker MA, Dodson JW, Dowdell SE, Wang GZ, Goodman KB, Sehon CA, Harpel MR, Willette RN, Neeb MJ, Leach CA, Douglas SA. GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo. British Journal of Pharmacology. 161: 207-28. PMID 20718751 DOI: 10.1111/j.1476-5381.2010.00889.x  0.617
2008 Sehon CA, Wang GZ, Viet AQ, Goodman KB, Dowdell SE, Elkins PA, Semus SF, Evans C, Jolivette LJ, Kirkpatrick RB, Dul E, Khandekar SS, Yi T, Wright LL, Smith GK, et al. Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases. Journal of Medicinal Chemistry. 51: 6631-4. PMID 18842034 DOI: 10.1021/jm8005096  0.355
2008 Hilfiker MA, Zhang D, Dowdell SE, Goodman KB, McAtee JJ, Dodson JW, Viet AQ, Wang GZ, Sehon CA, Behm DJ, Wu Z, Carballo LH, Douglas SA, Neeb MJ. Aminomethylpiperazines as selective urotensin antagonists. Bioorganic & Medicinal Chemistry Letters. 18: 4470-3. PMID 18674898 DOI: 10.1016/j.bmcl.2008.07.067  0.648
2008 McAtee JJ, Dodson JW, Dowdell SE, Erhard K, Girard GR, Goodman KB, Hilfiker MA, Jin J, Sehon CA, Sha D, Shi D, Wang F, Wang GZ, Wang N, Wang Y, et al. Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles. Bioorganic & Medicinal Chemistry Letters. 18: 3716-9. PMID 18524591 DOI: 10.1016/j.bmcl.2008.05.058  0.658
2008 McAtee JJ, Dodson JW, Dowdell SE, Girard GR, Goodman KB, Hilfiker MA, Sehon CA, Sha D, Wang GZ, Wang N, Viet AQ, Zhang D, Aiyar NV, Behm DJ, Carballo LH, et al. Development of potent and selective small-molecule human Urotensin-II antagonists. Bioorganic & Medicinal Chemistry Letters. 18: 3500-3. PMID 18502123 DOI: 10.1016/j.bmcl.2008.05.027  0.678
2007 Gomez L, Hack MD, McClure K, Sehon C, Huang L, Morton M, Li L, Barrett TD, Shankley N, Breitenbucher JG. SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 6493-8. PMID 17933530 DOI: 10.1016/j.bmcl.2007.09.093  0.402
2007 Goodman KB, Cui H, Dowdell SE, Gaitanopoulos DE, Ivy RL, Sehon CA, Stavenger RA, Wang GZ, Viet AQ, Xu W, Ye G, Semus SF, Evans C, Fries HE, Jolivette LJ, et al. Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. Journal of Medicinal Chemistry. 50: 6-9. PMID 17201405 DOI: 10.1021/jm0609014  0.365
2006 Grice CA, Tays K, Khatuya H, Gustin DJ, Butler CR, Wei J, Sehon CA, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 2209-12. PMID 16458510 DOI: 10.1016/j.bmcl.2006.01.038  0.308
2006 McClure K, Hack M, Huang L, Sehon C, Morton M, Li L, Barrett TD, Shankley N, Breitenbucher JG. Pyrazole CCK(1) receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity. Bioorganic & Medicinal Chemistry Letters. 16: 72-6. PMID 16236513 DOI: 10.1016/j.bmcl.2005.09.048  0.329
2006 Sehon C, McClure K, Hack M, Morton M, Gomez L, Li L, Barrett TD, Shankley N, Breitenbucher JG. Pyrazole CCK(1) receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity. Bioorganic & Medicinal Chemistry Letters. 16: 77-80. PMID 16236506 DOI: 10.1016/j.bmcl.2005.09.041  0.313
2005 Gustin DJ, Sehon CA, Wei J, Cai H, Meduna SP, Khatuya H, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 1687-91. PMID 15745822 DOI: 10.1016/j.bmcl.2005.01.045  0.372
1999 Marshall JA, Sehon CA. Isomerization of β-alkynyl allylic alcohols to furans catalyzed by silver nitrate on silica gel: 2-pentyl-3-methyl-5-heptylfuran Organic Syntheses. 76: 263-269.  0.303
1997 Marshall JA, Sehon CA. Total Synthesis of the Enantiomer of the Furanocembrane Rubifolide. The Journal of Organic Chemistry. 62: 4313-4320. PMID 11671752 DOI: 10.1021/Jo970360D  0.332
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