Matthew P. Bourbeau - Publications

2004 University of Virginia, Charlottesville, VA 

17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Pennington LD, Bartberger MD, Croghan MD, Andrews KL, Ashton KS, Bourbeau MP, Chen J, Chmait S, Cupples R, Fotsch C, Helmering J, Hong FT, Hungate RW, Jordan SR, Kong K, et al. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N→S (nN→σ*S-X) Interaction for Conformational Constraint. Journal of Medicinal Chemistry. PMID 26551034 DOI: 10.1021/acs.jmedchem.5b01367  0.64
2015 Bourbeau MP, Bartberger MD. Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease. Journal of Medicinal Chemistry. 58: 525-36. PMID 25333641 DOI: 10.1021/jm500695e  0.64
2014 Hu E, Chen N, Bourbeau MP, Harrington PE, Biswas K, Kunz RK, Andrews KL, Chmait S, Zhao X, Davis C, Ma J, Shi J, Lester-Zeiner D, Danao J, Able J, et al. Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). Journal of Medicinal Chemistry. 57: 6632-41. PMID 25062128 DOI: 10.1021/jm500713j  0.64
2014 Bourbeau MP, Ashton KS, Yan J, St Jean DJ. Nonracemic synthesis of GK-GKRP disruptor AMG-3969. The Journal of Organic Chemistry. 79: 3684-7. PMID 24678849 DOI: 10.1021/jo500336e  0.64
2013 Bourbeau MP, Siegmund A, Allen JG, Shu H, Fotsch C, Bartberger MD, Kim KW, Komorowski R, Graham M, Busby J, Wang M, Meyer J, Xu Y, Salyers K, Fielden M, et al. Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase. Journal of Medicinal Chemistry. 56: 10132-41. PMID 24294923 DOI: 10.1021/jm401601s  0.64
2013 Harrington PE, Bourbeau MP, Fotsch C, Frohn M, Pickrell AJ, Reichelt A, Sham K, Siegmund AC, Bailis JM, Bush T, Escobar S, Hickman D, Heller S, Hsieh F, Orf JN, et al. The optimization of aminooxadiazoles as orally active inhibitors of Cdc7. Bioorganic & Medicinal Chemistry Letters. 23: 6396-400. PMID 24120542 DOI: 10.1016/j.bmcl.2013.09.055  0.64
2010 Zeng Q, Allen JG, Bourbeau MP, Wang X, Yao G, Tadesse S, Rider JT, Yuan CC, Hong FT, Lee MR, Zhang S, Lofgren JA, Freeman DJ, Yang S, Li C, et al. Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorganic & Medicinal Chemistry Letters. 20: 1559-64. PMID 20137943 DOI: 10.1016/j.bmcl.2010.01.067  0.64
2010 Zeng Q, Bourbeau MP, Wohlhieter GE, Yao G, Monenschein H, Rider JT, Lee MR, Zhang S, Lofgren J, Freeman D, Li C, Tominey E, Huang X, Hoffman D, Yamane H, et al. 2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics. Bioorganic & Medicinal Chemistry Letters. 20: 1652-6. PMID 20137932 DOI: 10.1016/j.bmcl.2010.01.046  0.64
2010 Subramanian R, Lee MR, Allen JG, Bourbeau MP, Fotsch C, Hong FT, Tadesse S, Yao G, Yuan CC, Surapaneni S, Skiles GL, Wang X, Wohlhieter GE, Zeng Q, Zhou Y, et al. Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening. Chemical Research in Toxicology. 23: 653-63. PMID 20095585 DOI: 10.1021/tx900414g  0.64
2010 Bourbeau MP, Allen JG, Gu W. Recent Advances in Acetyl-CoA Carboxylase Inhibitors Annual Reports in Medicinal Chemistry. 45: 95-108. DOI: 10.1016/S0065-7743(10)45006-X  0.64
2009 Allen JG, Bourbeau MP, Wohlhieter GE, Bartberger MD, Michelsen K, Hungate R, Gadwood RC, Gaston RD, Evans B, Mann LW, Matison ME, Schneider S, Huang X, Yu D, Andrews PS, et al. Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. Journal of Medicinal Chemistry. 52: 7044-53. PMID 19856920 DOI: 10.1021/jm900681h  0.64
2006 Bourbeau MP, Rider JT. A convenient synthesis of 4-alkyl-5-aminoisoxazoles. Organic Letters. 8: 3679-80. PMID 16898790 DOI: 10.1021/ol061260+  0.64
2006 Marshall JA, Mikowski AM, Bourbeau MP, Schaaf GM, Valeriote F. Leptostatin: a synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B. Bioorganic & Medicinal Chemistry Letters. 16: 320-3. PMID 16271470 DOI: 10.1016/j.bmcl.2005.09.084  0.64
2003 Marshall JA, Bourbeau MP. Synthesis of enantioenriched propargylic alcohols related to polyketide natural products. A comparison of methodologies. Organic Letters. 5: 3197-9. PMID 12943386 DOI: 10.1021/ol034918h  0.64
2003 Marshall JA, Bourbeau MP. Directed Pd(0)-catalyzed hydrostannations of internal alkynes Tetrahedron Letters. 44: 1087-1089. DOI: 10.1016/S0040-4039(02)02660-6  0.64
2002 Marshall JA, Bourbeau MP. Second-generation synthesis of the polypropionate subunit of callystatin A based on regioselective internal alkyne hydrostannation. Organic Letters. 4: 3931-4. PMID 12599495 DOI: 10.1021/ol026791m  0.64
2002 Marshall JA, Bourbeau MP. Total synthesis of (-)-callystatin A. The Journal of Organic Chemistry. 67: 2751-4. PMID 11975524 DOI: 10.1021/jo016025d  0.64
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