Milton Brown - Publications

Affiliations: 
2004 Chemistry University of Virginia, Charlottesville, VA 

99 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Das A, Merrill P, Wilson J, Turner T, Paige M, Capitosti S, Brown M, Freshcorn B, Sok MCP, Song H, Botchwey EA. Evaluating Angiogenic Potential of Small Molecules Using Genetic Network Approaches. Regenerative Engineering and Translational Medicine. 5: 30-41. PMID 31008183 DOI: 10.1007/s40883-018-0077-8  0.64
2018 Levin ED, Rezvani AH, Wells C, Slade S, Yenugonda VM, Liu Y, Brown ML, Xiao Y, Kellar KJ. α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats. European Journal of Pharmacology. PMID 30529197 DOI: 10.1016/j.ejphar.2018.12.010  0.32
2018 Lawless OJ, Bellanti JA, Brown ML, Sandberg K, Umans JG, Zhou L, Chen W, Wang J, Wang K, Zheng SG. induction of T regulatory cells by a methylated CpG DNA sequence in humans: Potential therapeutic applications in allergic and autoimmune diseases. Allergy and Asthma Proceedings. 39: 143-152. PMID 29490770 DOI: 10.2500/aap.2018.39.4113  0.44
2017 Rezvani AH, Slade S, Wells C, Yenugonda VM, Liu Y, Brown ML, Xiao Y, Kellar KJ, Levin ED. Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats. Psychopharmacology. PMID 28555315 DOI: 10.1007/s00213-017-4641-6  0.32
2016 Cordova A, Woodrick J, Grindrod S, Zhang L, Saygideger-Kont Y, Wang K, DeVito S, Daniele S, Paige M, Brown ML. Aminopeptidase P mediated targeting for breast tissue specific conjugate delivery. Bioconjugate Chemistry. PMID 26965452 DOI: 10.1021/acs.bioconjchem.5b00481  0.64
2015 Ma Y, Preet A, Tomita Y, De Oliveira E, Zhang L, Ueda Y, Clarke R, Brown M, Rosen EM. A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance. Oncotarget. PMID 26575173 DOI: 10.18632/oncotarget.6323  0.36
2015 Niu T, Liu N, Yu X, Zhao M, Choi HJ, Leo PJ, Brown MA, Zhang L, Pei YF, Shen H, He H, Fu X, Lu S, Chen XD, Tan LJ, et al. Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26256109 DOI: 10.1002/jbmr.2687  0.36
2015 Niu T, Liu N, Zhao M, Xie G, Zhang L, Li J, Pei YF, Shen H, Fu X, He H, Lu S, Chen XD, Tan LJ, Yang TL, Guo Y, ... ... Brown MA, et al. Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies. Human Molecular Genetics. 24: 4710-27. PMID 25941324 DOI: 10.1093/hmg/ddv144  0.36
2015 Hou S, Liu Y, Kong Y, Brown ML. Total Synthesis of 7-Hydroxymurrayazolinine, Murrayamine D, and Mahanine via m-Nitro Group Activated Pyran Annulation. Organic Letters. 17: 2298-301. PMID 25919697 DOI: 10.1021/acs.orglett.5b00422  0.96
2015 Kong H, Song JK, Yenugonda VM, Zhang L, Shuo T, Cheema AK, Kong Y, Du GH, Brown ML. Preclinical studies of the potent and selective nicotinic α4β2 receptor ligand VMY-2-95. Molecular Pharmaceutics. 12: 393-402. PMID 25533629 DOI: 10.1021/mp5003569  0.96
2015 Mounir Z, Lin F, Lin VG, Korn JM, Yu Y, Valdez R, Aina OH, Buchwalter G, Jaffe AB, Korpal M, Zhu P, Brown M, Cardiff RD, Rocnik JL, Yang Y, et al. TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation. Oncogene. 34: 3815-25. PMID 25263440 DOI: 10.1038/onc.2014.308  0.32
2014 Rahim S, Minas T, Hong SH, Justvig S, Çelik H, Kont YS, Han J, Kallarakal AT, Kong Y, Rudek MA, Brown ML, Kallakury B, Toretsky JA, Üren A. A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model. Plos One. 9: e114260. PMID 25479232 DOI: 10.1371/journal.pone.0114260  0.96
2014 Tosso PN, Kong Y, Scher L, Cummins R, Schneider J, Rahim S, Holman KT, Toretsky J, Wang K, Ãœren A, Brown ML. Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma. Journal of Medicinal Chemistry. 57: 10290-303. PMID 25432018 DOI: 10.1021/jm501372p  0.96
2014 Ma Y, Tomita Y, Preet A, Clarke R, Englund E, Grindrod S, Nathan S, De Oliveira E, Brown ML, Rosen EM. Small-molecule "BRCA1-mimetics" are antagonists of estrogen receptor-α. Molecular Endocrinology (Baltimore, Md.). 28: 1971-86. PMID 25264941 DOI: 10.1210/me.2014-1146  0.96
2014 Hou S, Yi YW, Kang HJ, Zhang L, Kim HJ, Kong Y, Liu Y, Wang K, Kong HS, Grindrod S, Bae I, Brown ML. Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6. Journal of Medicinal Chemistry. 57: 6342-53. PMID 24978112 DOI: 10.1021/jm4018042  0.96
2014 Liu Y, Paige M, Olson TT, Al-Muhtasib N, Xie T, Hou S, White MP, Cordova A, Guo JL, Kellar KJ, Xiao Y, Brown ML. Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A. Bioorganic & Medicinal Chemistry Letters. 24: 2954-6. PMID 24844195 DOI: 10.1016/j.bmcl.2014.04.036  0.96
2014 Ellingson SR, Dakshanamurthy S, Brown M, Smith JC, Baudry J. Accelerating Virtual High-Throughput Ligand Docking: current technology and case study on a petascale supercomputer. Concurrency and Computation : Practice & Experience. 26: 1268-1277. PMID 24729746 DOI: 10.1002/cpe.3070  0.96
2014 Assefnia S, Dakshanamurthy S, Guidry Auvil JM, Hampel C, Anastasiadis PZ, Kallakury B, Uren A, Foley DW, Brown ML, Shapiro L, Brenner M, Haigh D, Byers SW. Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. Oncotarget. 5: 1458-74. PMID 24681547  0.96
2014 Paige M, Kosturko G, Bulut G, Miessau M, Rahim S, Toretsky JA, Brown ML, Üren A. Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma. Bioorganic & Medicinal Chemistry. 22: 478-87. PMID 24326277 DOI: 10.1016/j.bmc.2013.11.003  0.96
2013 Fan S, Meng Q, Xu J, Jiao Y, Zhao L, Zhang X, Sarkar FH, Brown ML, Dritschilo A, Rosen EM. DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. Proceedings of the National Academy of Sciences of the United States of America. 110: 18650-5. PMID 24127581 DOI: 10.1073/pnas.1308206110  0.96
2013 Yenugonda VM, Xiao Y, Levin ED, Rezvani AH, Tran T, Al-Muhtasib N, Sahibzada N, Xie T, Wells C, Slade S, Johnson JE, Dakshanamurthy S, Kong HS, Tomita Y, Liu Y, ... ... Brown ML, et al. Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands. Journal of Medicinal Chemistry. 56: 8404-21. PMID 24047231 DOI: 10.1021/jm4008455  0.96
2013 Levin ED, Sexton HG, Gordon K, Gordon CJ, Xiao Y, Kellar KJ, Yenugonda VM, Liu Y, White MP, Paige M, Brown ML, Rezvani AH. Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice. European Journal of Pharmacology. 718: 167-72. PMID 24036108 DOI: 10.1016/j.ejphar.2013.08.037  0.96
2013 Yi YW, Kang HJ, Kim HJ, Kong Y, Brown ML, Bae I. Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget. 4: 984-94. PMID 23846322 DOI: 10.18632/oncotarget.1070  0.96
2013 Liu Y, Richardson J, Tran T, Al-Muhtasib N, Xie T, Yenugonda VM, Sexton HG, Rezvani AH, Levin ED, Sahibzada N, Kellar KJ, Brown ML, Xiao Y, Paige M. Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. Journal of Medicinal Chemistry. 56: 3000-11. PMID 23540678 DOI: 10.1021/jm4000374  0.96
2013 Timofeeva OA, Tarasova NI, Zhang X, Chasovskikh S, Cheema AK, Wang H, Brown ML, Dritschilo A. STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. Proceedings of the National Academy of Sciences of the United States of America. 110: 1267-72. PMID 23288901 DOI: 10.1073/pnas.1211805110  0.96
2012 Suy S, Hansen TP, Auto HD, Kallakury BV, Dailey V, Danner M, Macarthur L, Zhang Y, Miessau MJ, Collins SP, Brown ML. Expression of Voltage-Gated Sodium Channel Nav1.8 in Human Prostate Cancer is Associated with High Histological Grade. Journal of Clinical & Experimental Oncology. 1. PMID 24163825 DOI: 10.4172/2324-9110.1000102  0.96
2012 Walls TH, Grindrod SC, Beraud D, Zhang L, Baheti AR, Dakshanamurthy S, Patel MK, Brown ML, MacArthur LH. Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent. Bioorganic & Medicinal Chemistry. 20: 5269-76. PMID 22863530 DOI: 10.1016/j.bmc.2012.06.042  0.96
2012 Kong HS, Tian S, Kong Y, Du G, Zhang L, Jung M, Dritschilo A, Brown ML. Preclinical studies of YK-4-272, an inhibitor of class II histone deacetylases by disruption of nucleocytoplasmic shuttling. Pharmaceutical Research. 29: 3373-83. PMID 22836184 DOI: 10.1007/s11095-012-0832-3  0.96
2012 Yenugonda VM, Kong Y, Deb TB, Yang Y, Riggins RB, Brown ML. Trans-resveratrol boronic acid exhibits enhanced anti-proliferative activity on estrogen-dependent MCF-7 breast cancer cells. Cancer Biology & Therapy. 13: 925-34. PMID 22785207 DOI: 10.4161/cbt.20845  0.96
2012 Dakshanamurthy S, Issa NT, Assefnia S, Seshasayee A, Peters OJ, Madhavan S, Uren A, Brown ML, Byers SW. Predicting new indications for approved drugs using a proteochemometric method. Journal of Medicinal Chemistry. 55: 6832-48. PMID 22780961 DOI: 10.1021/jm300576q  0.96
2012 Barber-Rotenberg JS, Selvanathan SP, Kong Y, Erkizan HV, Snyder TM, Hong SP, Kobs CL, South NL, Summer S, Monroe PJ, Chruszcz M, Dobrev V, Tosso PN, Scher LJ, Minor W, ... Brown ML, et al. Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget. 3: 172-82. PMID 22383402  0.96
2012 Timofeeva OA, Chasovskikh S, Lonskaya I, Tarasova NI, Khavrutskii L, Tarasov SG, Zhang X, Korostyshevskiy VR, Cheema A, Zhang L, Dakshanamurthy S, Brown ML, Dritschilo A. Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA. The Journal of Biological Chemistry. 287: 14192-200. PMID 22378781 DOI: 10.1074/jbc.M111.323899  0.96
2012 Davis GC, Kong Y, Paige M, Li Z, Merrick EC, Hansen T, Suy S, Wang K, Dakshanamurthy S, Cordova A, McManus OB, Williams BS, Chruszcz M, Minor W, Patel MK, ... Brown ML, et al. Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts. Bioorganic & Medicinal Chemistry. 20: 2180-8. PMID 22364743 DOI: 10.1016/j.bmc.2011.08.061  0.96
2012 Johnson JE, Slade S, Wells C, Petro A, Sexton H, Rezvani AH, Brown ML, Paige MA, McDowell BE, Xiao Y, Kellar KJ, Levin ED. Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats. Psychopharmacology. 222: 269-76. PMID 22297831 DOI: 10.1007/s00213-012-2642-z  0.96
2012 Hartley RM, Peng J, Fest GA, Dakshanamurthy S, Frantz DE, Brown ML, Mooberry SL. Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site. Molecular Pharmacology. 81: 431-9. PMID 22169850 DOI: 10.1124/mol.111.075838  0.96
2012 Ellingson SR, Dakshanamurthy S, Brown M, Smith JC, Baudry J. Accelerating virtual high-throughput ligand docking: Screening one million compounds using a petascale supercomputer Ecmls 2012 - 3rd International Emerging Computational Methods For the Life Sciences Workshop. 33-37. DOI: 10.1145/2483954.2483961  0.96
2011 Grindrod S, Suy S, Fallen S, Eto M, Toretsky J, Brown ML. Effects of a fluorescent Myosin light chain phosphatase inhibitor on prostate cancer cells. Frontiers in Oncology. 1: 27. PMID 22655237 DOI: 10.3389/fonc.2011.00027  0.96
2011 Ringer L, Sirajuddin P, Heckler M, Ghosh A, Suprynowicz F, Yenugonda VM, Brown ML, Toretsky JA, Uren A, Lee Y, MacDonald TJ, Rodriguez O, Glazer RI, Schlegel R, Albanese C. VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells. Cancer Biology & Therapy. 12: 818-26. PMID 21885916 DOI: 10.4161/cbt.12.9.17682  0.96
2011 Kong Y, Jung M, Wang K, Grindrod S, Velena A, Lee SA, Dakshanamurthy S, Yang Y, Miessau M, Zheng C, Dritschilo A, Brown ML. Histone deacetylase cytoplasmic trapping by a novel fluorescent HDAC inhibitor. Molecular Cancer Therapeutics. 10: 1591-9. PMID 21697394 DOI: 10.1158/1535-7163.MCT-10-0779  0.96
2011 De Oliveira EO, Graf KM, Patel MK, Baheti A, Kong HS, MacArthur LH, Dakshanamurthy S, Wang K, Brown ML, Paige M. Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers. Bioorganic & Medicinal Chemistry. 19: 4322-9. PMID 21683602 DOI: 10.1016/j.bmc.2011.05.043  0.96
2011 Rahim S, Beauchamp EM, Kong Y, Brown ML, Toretsky JA, Üren A. YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion. Plos One. 6: e19343. PMID 21559405 DOI: 10.1371/journal.pone.0019343  0.96
2011 Yenugonda VM, Deb TB, Grindrod SC, Dakshanamurthy S, Yang Y, Paige M, Brown ML. Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells. Bioorganic & Medicinal Chemistry. 19: 2714-25. PMID 21440449 DOI: 10.1016/j.bmc.2011.02.052  0.96
2011 Rezvani AH, Cauley M, Sexton H, Xiao Y, Brown ML, Paige MA, McDowell BE, Kellar KJ, Levin ED. Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats. Psychopharmacology. 215: 621-30. PMID 21274704 DOI: 10.1007/s00213-010-2161-8  0.96
2010 Awad O, Yustein JT, Shah P, Gul N, Katuri V, O'Neill A, Kong Y, Brown ML, Toretsky JA, Loeb DM. High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. Plos One. 5: e13943. PMID 21085683 DOI: 10.1371/journal.pone.0013943  0.96
2010 Ringer L, Sirajuddin P, Yenugonda VM, Ghosh A, Divito K, Trabosh V, Patel Y, Brophy A, Grindrod S, Lisanti MP, Rosenthal D, Brown ML, Avantaggiati ML, Rodriguez O, Albanese C. VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells. Cancer Biology & Therapy. 10: 320-5. PMID 20574155 DOI: 10.4161/cbt.10.4.12208  0.96
2010 Rezvani AH, Slade S, Wells C, Petro A, Lumeng L, Li TK, Xiao Y, Brown ML, Paige MA, McDowell BE, Rose JE, Kellar KJ, Levin ED. Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats. Psychopharmacology. 211: 161-74. PMID 20535453 DOI: 10.1007/s00213-010-1878-8  0.96
2010 Sheikh KD, Banerjee PP, Jagadeesh S, Grindrod SC, Zhang L, Paige M, Brown ML. Fluorescent epigenetic small molecule induces expression of the tumor suppressor ras-association domain family 1A and inhibits human prostate xenograft. Journal of Medicinal Chemistry. 53: 2376-82. PMID 20184324 DOI: 10.1021/jm9011615  0.96
2010 Hans SK, Camara F, Altiti A, Martín-Montalvo A, Brautigan DL, Heimark D, Larner J, Grindrod S, Brown ML, Mootoo DR. Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha. Bioorganic & Medicinal Chemistry. 18: 1103-10. PMID 20079654 DOI: 10.1016/j.bmc.2009.12.056  0.96
2010 Levin ED, Rezvani AH, Xiao Y, Slade S, Cauley M, Wells C, Hampton D, Petro A, Rose JE, Brown ML, Paige MA, McDowell BE, Kellar KJ. Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats. The Journal of Pharmacology and Experimental Therapeutics. 332: 933-9. PMID 20007754 DOI: 10.1124/jpet.109.162073  0.96
2010 Kong Y, Wang K, Edler MC, Hamel E, Mooberry SL, Paige MA, Brown ML. A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent. Bioorganic & Medicinal Chemistry. 18: 971-7. PMID 20006519 DOI: 10.1016/j.bmc.2009.11.003  0.96
2009 Graf KM, Tabor MG, Brown ML, Paige M. Synthesis of (S)-jamaicamide C carboxylic acid. Organic Letters. 11: 5382-5. PMID 19943696 DOI: 10.1021/ol9021222  0.96
2009 Brown ML, Eidam HA, Paige M, Jones PJ, Patel MK. Comparative molecular field analysis and synthetic validation of a hydroxyamide-propofol binding and functional block of neuronal voltage-dependent sodium channels. Bioorganic & Medicinal Chemistry. 17: 7056-63. PMID 19747831 DOI: 10.1016/j.bmc.2008.11.069  0.96
2009 Timofeeva OA, Zhang X, Ressom HW, Varghese RS, Kallakury BV, Wang K, Ji Y, Cheema A, Jung M, Brown ML, Rhim JS, Dritschilo A. Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African-American men. International Journal of Oncology. 35: 751-60. PMID 19724911 DOI: 10.3892/ijo-00000388  0.96
2009 Erkizan HV, Kong Y, Merchant M, Schlottmann S, Barber-Rotenberg JS, Yuan L, Abaan OD, Chou TH, Dakshanamurthy S, Brown ML, Uren A, Toretsky JA. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nature Medicine. 15: 750-6. PMID 19584866 DOI: 10.1038/nm.1983  0.96
2009 Park HU, Suy S, Danner M, Dailey V, Zhang Y, Li H, Hyduke DR, Collins BT, Gagnon G, Kallakury B, Kumar D, Brown ML, Fornace A, Dritschilo A, Collins SP. AMP-activated protein kinase promotes human prostate cancer cell growth and survival. Molecular Cancer Therapeutics. 8: 733-41. PMID 19372545 DOI: 10.1158/1535-7163.MCT-08-0631  0.96
2009 Wang Y, Jones PJ, Batts TW, Landry V, Patel MK, Brown ML. Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore. Bioorganic & Medicinal Chemistry. 17: 7064-72. PMID 19346132 DOI: 10.1016/j.bmc.2008.10.031  0.96
2009 Wieghaus KA, Gianchandani EP, Neal RA, Paige MA, Brown ML, Papin JA, Botchwey EA. Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells. Biotechnology and Bioengineering. 103: 796-807. PMID 19326468 DOI: 10.1002/bit.22310  0.96
2009 Jones PJ, Merrick EC, Batts TW, Hargus NJ, Wang Y, Stables JP, Bertram EH, Brown ML, Patel MK. Modulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsy. The Journal of Pharmacology and Experimental Therapeutics. 328: 201-12. PMID 18952887 DOI: 10.1124/jpet.108.144709  0.96
2009 Federoff HJ, Brown M, Dakshanamurthy S, Maguire-Zeiss K. Potential of Nurr1 interactions to disclose new Parkinson's therapeutics Future Neurology. 4: 161-165. DOI: 10.2217/14796708.4.2.161  0.96
2008 Wieghaus KA, Nickerson MM, Petrie Aronin CE, Sefcik LS, Price RJ, Paige MA, Brown ML, Botchwey EA. Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1). Biomaterials. 29: 4698-708. PMID 18804278 DOI: 10.1016/j.biomaterials.2008.08.029  0.96
2008 Wieghaus KA, Gianchandani EP, Paige MA, Brown ML, Botchwey EA, Papin JA. Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule. Bioinformatics (Oxford, England). 24: 2384-90. PMID 18718940 DOI: 10.1093/bioinformatics/btn451  0.96
2008 Chinigo GM, Paige M, Grindrod S, Hamel E, Dakshanamurthy S, Chruszcz M, Minor W, Brown ML. Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity. Journal of Medicinal Chemistry. 51: 4620-31. PMID 18610995 DOI: 10.1021/jm800271c  0.96
2008 Lyles RH, Poindexter C, Evans A, Brown M, Cooper CR. Nonlinear model-based estimates of IC(50) for studies involving continuous therapeutic dose-response data. Contemporary Clinical Trials. 29: 878-86. PMID 18582601 DOI: 10.1016/j.cct.2008.05.009  0.96
2008 Hwang SH, Rait A, Pirollo KF, Zhou Q, Yenugonda VM, Chinigo GM, Brown ML, Chang EH. Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue. Molecular Cancer Therapeutics. 7: 559-68. PMID 18347143 DOI: 10.1158/1535-7163.MCT-07-0548  0.96
2008 Mocchetti I, Brown M. Targeting neurotrophin receptors in the central nervous system. Cns & Neurological Disorders Drug Targets. 7: 71-82. PMID 18289034 DOI: 10.2174/187152708783885138  0.96
2007 Gorczynski MJ, Grembecka J, Zhou Y, Kong Y, Roudaia L, Douvas MG, Newman M, Bielnicka I, Baber G, Corpora T, Shi J, Sridharan M, Lilien R, Donald BR, Speck NA, ... Brown ML, et al. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chemistry & Biology. 14: 1186-97. PMID 17961830 DOI: 10.1016/j.chembiol.2007.09.006  0.96
2007 Wieghaus KA, Gianchandani EP, Brown ML, Papin JA, Botchwey EA. Mechanistic exploration of phthalimide neovascular factor 1 using network analysis tools. Tissue Engineering. 13: 2561-75. PMID 17723106 DOI: 10.1089/ten.2007.0023  0.96
2007 Holder S, Lilly M, Brown ML. Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase. Bioorganic & Medicinal Chemistry. 15: 6463-73. PMID 17637507 DOI: 10.1016/j.bmc.2007.06.025  0.96
2007 Dakshanamurthy S, Kim M, Brown ML, Byers SW. In-silico fragment-based identification of novel angiogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 4551-6. PMID 17591441 DOI: 10.1016/j.bmcl.2007.05.104  0.96
2007 Mooberry SL, Weiderhold KN, Dakshanamurthy S, Hamel E, Banner EJ, Kharlamova A, Hempel J, Gupton JT, Brown ML. Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole Molecular Pharmacology. 72: 132-140. PMID 17456786 DOI: 10.1124/mol.107.034876  0.96
2007 Lenkowski PW, Batts TW, Smith MD, Ko SH, Jones PJ, Taylor CH, McCusker AK, Davis GC, Hartmann HA, White HS, Brown ML, Patel MK. A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile. Neuropharmacology. 52: 1044-54. PMID 17174360 DOI: 10.1016/j.neuropharm.2006.11.001  0.96
2007 Jones PJ, Wang Y, Smith MD, Hargus NJ, Eidam HS, White HS, Kapur J, Brown ML, Patel MK. Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity. The Journal of Pharmacology and Experimental Therapeutics. 320: 828-36. PMID 17090703 DOI: 10.1124/jpet.106.111542  0.96
2007 Chruszcz M, Kong Y, Dauter Z, Brown ML, Minor W. 2-Amino-4-(4-chloro-3-methylphenyl)-5-propyl-1,3-thiazolium iodide Acta Crystallographica Section E: Structure Reports Online. 63: o1598-o1600. DOI: 10.1107/S1600536807009427  0.96
2007 Chruszcz M, Chinigo GM, Capitosti SM, Brown ML, Minor W. 2-(Biphenyl-4-yl)-2,3-dihydroquinazolin-4(1H)-one Acta Crystallographica Section E: Structure Reports Online. 63: o891-o893. DOI: 10.1107/S1600536807002103  0.96
2007 Fumino K, Diakova G, Andersen JD, Brown ML, Bryant RG. Solvation and intermolecular exploration of drug molecule fragments Journal of Solution Chemistry. 36: 715-722. DOI: 10.1007/s10953-007-9142-5  0.96
2006 Fiske JL, Fomin VP, Brown ML, Duncan RL, Sikes RA. Voltage-sensitive ion channels and cancer. Cancer Metastasis Reviews. 25: 493-500. PMID 17111226 DOI: 10.1007/s10555-006-9017-z  0.96
2006 Hudgens DP, Taylor C, Batts TW, Patel MK, Brown ML. Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2. Bioorganic & Medicinal Chemistry. 14: 8366-78. PMID 17035036 DOI: 10.1016/j.bmc.2006.09.010  0.96
2006 Wieghaus KA, Capitosti SM, Anderson CR, Price RJ, Blackman BR, Brown ML, Botchwey EA. Small molecule inducers of angiogenesis for tissue engineering. Tissue Engineering. 12: 1903-13. PMID 16889520 DOI: 10.1089/ten.2006.12.1903  0.96
2006 Ko SH, Jochnowitz N, Lenkowski PW, Batts TW, Davis GC, Martin WJ, Brown ML, Patel MK. Reversal of neuropathic pain by alpha-hydroxyphenylamide: a novel sodium channel antagonist. Neuropharmacology. 50: 865-73. PMID 16464480 DOI: 10.1016/j.neuropharm.2005.12.008  0.96
2005 Kong Y, Grembecka J, Edler MC, Hamel E, Mooberry SL, Sabat M, Rieger J, Brown ML. Structure-based discovery of a boronic acid bioisostere of combretastatin A-4. Chemistry & Biology. 12: 1007-14. PMID 16183025 DOI: 10.1016/j.chembiol.2005.06.016  0.96
2005 Wieghaus KA, Capitosti SM, Brown ML, Botchwey EA. Small molecule stimulators of angiogenesis for bone tissue engineering Proceedings of the 2005 Summer Bioengineering Conference. 2005: 1182-1183.  0.96
2005 Wieghaus KA, Capitosti SM, Brown ML, Botchwey EA. Novel angiogenic compounds for targeted drug delivery Materials Research Society Symposium Proceedings. 845: 357-361.  0.96
2004 Brennen WN, Cooper CR, Capitosti S, Brown ML, Sikes RA. Thalidomide and analogues: current proposed mechanisms and therapeutic usage. Clinical Prostate Cancer. 3: 54-61. PMID 15279692  0.96
2004 Lenkowski PW, Ko SH, Anderson JD, Brown ML, Patel MK. Block of human NaV1.5 sodium channels by novel alpha-hydroxyphenylamide analogues of phenytoin. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 21: 635-44. PMID 15066664 DOI: 10.1016/j.ejps.2004.01.004  0.96
2004 Gorczynski MJ, Leal RM, Mooberry SL, Bushweller JH, Brown ML. Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation. Bioorganic & Medicinal Chemistry. 12: 1029-36. PMID 14980616 DOI: 10.1016/j.bmc.2003.12.003  0.96
2004 Schenck HA, Lenkowski PW, Choudhury-Mukherjee I, Ko SH, Stables JP, Patel MK, Brown ML. Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants. Bioorganic & Medicinal Chemistry. 12: 979-93. PMID 14980611 DOI: 10.1016/j.bmc.2003.12.011  0.96
2004 Capitosti SM, Hansen TP, Brown ML. Thalidomide analogues demonstrate dual inhibition of both angiogenesis and prostate cancer. Bioorganic & Medicinal Chemistry. 12: 327-36. PMID 14723953 DOI: 10.1016/j.bmc.2003.11.007  0.96
2003 Sikes RA, Walls AM, Brennen WN, Anderson JD, Choudhury-Mukherjee I, Schenck HA, Brown ML. Therapeutic approaches targeting prostate cancer progression using novel voltage-gated ion channel blockers. Clinical Prostate Cancer. 2: 181-7. PMID 15040863  0.96
2003 Haji-Momenian S, Rieger JM, Macdonald TL, Brown ML. Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6. Bioorganic & Medicinal Chemistry. 11: 5545-54. PMID 14642599 DOI: 10.1016/S0968-0896(03)00525-X  0.96
2003 Anderson JD, Hansen TP, Lenkowski PW, Walls AM, Choudhury IM, Schenck HA, Friehling M, Höll GM, Patel MK, Sikes RA, Brown ML. Voltage-gated sodium channel blockers as cytostatic inhibitors of the androgen-independent prostate cancer cell line PC-3. Molecular Cancer Therapeutics. 2: 1149-54. PMID 14617788  0.96
2003 Grimm JB, Stables JP, Brown ML. Design, synthesis, and development of novel caprolactam anticonvulsants. Bioorganic & Medicinal Chemistry. 11: 4133-41. PMID 12927875 DOI: 10.1016/S0968-0896(03)00400-0  0.96
2003 Capitosti SM, Hansen TP, Brown ML. Facile synthesis of an azido-labeled thalidomide analogue. Organic Letters. 5: 2865-7. PMID 12889894 DOI: 10.1021/ol034906w  0.96
2003 Choudhury-Mukherjee I, Schenck HA, Cechova S, Pajewski TN, Kapur J, Ellena J, Cafiso DS, Brown ML. Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics. Journal of Medicinal Chemistry. 46: 2494-501. PMID 12773053 DOI: 10.1021/jm020546r  0.96
2002 Kumar R, Eastwood AL, Brown ML, Laurie GW. Human genome search in celiac disease: mutated gliadin T-cell-like epitope in two human proteins promotes T-cell activation. Journal of Molecular Biology. 319: 593-602. PMID 12054857 DOI: 10.1016/S0022-2836(02)00366-2  0.96
2001 Rieger JM, Brown ML, Sullivan GW, Linden J, Macdonald TL. Design, synthesis, and evaluation of novel A2A adenosine receptor agonists Journal of Medicinal Chemistry. 44: 531-539. PMID 11170643 DOI: 10.1021/jm0003642  0.96
2000 Brown ML, Rieger JM, Macdonald TL. Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on beta-tubulin. Bioorganic & Medicinal Chemistry. 8: 1433-41. PMID 10896120 DOI: 10.1016/S0968-0896(00)00068-7  0.96
1999 Brown ML, Zha CC, Van Dyke CC, Brown GB, Brouillette WJ. Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel Journal of Medicinal Chemistry. 42: 1537-1545. PMID 10229624 DOI: 10.1021/jm980556l  0.96
1997 Brown ML, Brown GB, Brouillette WJ. Effects of log P and phenyl ring conformation on the binding of 5- phenylhydantoins to the voltage-dependent sodium channel Journal of Medicinal Chemistry. 40: 602-607. PMID 9046351 DOI: 10.1021/jm960692v  0.96
1994 Brouillette WJ, Jestkov VP, Brown ML, Akhtar MS, DeLorey TM, Brown GB. Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel. Journal of Medicinal Chemistry. 37: 3289-93. PMID 7932556  0.96
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