D. Borden Lacy, Ph.D. - Publications

Affiliations: 
1990-1994 University of North Carolina, Chapel Hill, Chapel Hill, NC 
 1994-1999 University of California, Berkeley, Berkeley, CA 
 1999- Vanderbilt University, Nashville, TN 

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Parnell JM, Fazili I, Bloch SC, Lacy DB, Garcia-Lopez VA, Bernard R, Skaar EP, Edwards KM, Nicholson MR. Two-Step Testing for Clostridioides Difficile is Inadequate in Differentiating Infection From Colonization in Children. Journal of Pediatric Gastroenterology and Nutrition. PMID 32925555 DOI: 10.1097/Mpg.0000000000002944  0.4
2020 Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, ... Lacy DB, et al. infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 32198200 DOI: 10.1073/Pnas.1915255117  0.4
2020 Tam J, Icho S, Utama E, Orrell KE, Gómez-Biagi RF, Theriot CM, Kroh HK, Rutherford SA, Lacy DB, Melnyk RA. Intestinal bile acids directly modulate the structure and function of TcdB toxin. Proceedings of the National Academy of Sciences of the United States of America. PMID 32152097 DOI: 10.1073/Pnas.1916965117  0.4
2020 Farrow MA, Chumbler NM, Bloch SC, King M, Moton-Melancon K, Shupe J, Washington MK, Spiller BW, Lacy DB. A small molecule inhibitor screen reveals calcium channel signaling as a mechanistic mediator of Clostridium difficile TcdB-induced necrosis. Acs Chemical Biology. PMID 31909964 DOI: 10.1021/Acschembio.9B00906  0.4
2019 Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD. Structure of the Cag Type IV secretion system. Elife. 8. PMID 31210639 DOI: 10.7554/Elife.47644  0.44
2019 Palmer LD, Jordan AT, Maloney KN, Farrow MA, Gutierrez DB, Gant-Branum R, Burns WJ, Romer CE, Tsui T, Allen JL, Beavers WN, Nei YW, Sherrod SD, Lacy DB, Norris JL, et al. Zinc intoxication induces ferroptosis in A549 human lung cells. Metallomics : Integrated Biometal Science. PMID 30968088 DOI: 10.1039/C8Mt00360B  0.4
2017 Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB. A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells. The Journal of Biological Chemistry. PMID 29180448 DOI: 10.1074/jbc.M117.813428  0.4
2017 Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB. Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface. The Journal of Biological Chemistry. PMID 28705932 DOI: 10.1074/Jbc.M117.781112  0.4
2017 Alvin JW, Lacy DB. Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. Journal of Structural Biology. 198: 203-209. PMID 28433497 DOI: 10.1016/J.Jsb.2017.04.006  1
2017 Hernandez LD, Kroh HK, Hsieh E, Yang X, Beaumont M, Sheth PR, DiNunzio E, Rutherford SA, Ohi MD, Ermakov G, Xiao L, Secore S, Karczewski J, Racine F, Mayhood T, ... ... Lacy DB, et al. Epitopes and Mechanism of Action of the Clostridium Difficile Toxin A-Neutralizing Antibody Actoxumab. Journal of Molecular Biology. PMID 28232034 DOI: 10.1016/J.Jmb.2017.02.010  0.4
2017 Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan AT, Burns W, Poland JC, Romer CE, Manier ML, ... ... Lacy DB, et al. An integrated, high-throughput, multi-omics platform enables data-driven construction of cellular responses and reveals global drug mechanisms of action. Journal of Proteome Research. PMID 28088864 DOI: 10.1021/Acs.Jproteome.6B01004  0.4
2017 Alvin JW, Lacy DB. Structure Function Studies of Large Clostridial Cytotoxins Toxinology. 1-18. DOI: 10.1007/978-94-007-6725-6_26-2  1
2016 Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB. Crystal structure of Clostridium difficile toxin A. Nature Microbiology. 1: 15002. PMID 27571750 DOI: 10.1038/Nmicrobiol.2015.2  0.4
2016 Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB. Crystal structure of Clostridium difficile toxin A. Nature Microbiology. 1. PMID 27512603 DOI: 10.1038/nmicrobiol.2015.2  0.4
2016 Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Lacy DB. Clostridium difficile toxins TcdA and TcdB cause colonic tissue damage by distinct mechanisms. Infection and Immunity. PMID 27456833 DOI: 10.1128/Iai.00583-16  0.4
2016 González-Rivera C, Campbell AM, Rutherford SA, Pyburn TM, Foegeding NJ, Barke TL, Spiller BW, McClain MS, Ohi MD, Lacy DB, Cover TL. A non-oligomerizing mutant form of Helicobacter pylori VacA allows structural analysis of the p33 domain. Infection and Immunity. PMID 27382020 DOI: 10.1128/Iai.00254-16  0.44
2016 Reyes-Robles T, Lubkin A, Alonzo F, Lacy DB, Torres VJ. Exploiting dominant-negative toxins to combat Staphylococcus aureus pathogenesis. Embo Reports. PMID 26882549 DOI: 10.15252/Embr.201540994  0.8
2016 Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E. Analysis of TcdBs within the hypervirulent clade 2 reveals an impact of RhoA glucosylation in Clostridium difficile pro inflammatory activities. Infection and Immunity. PMID 26755157 DOI: 10.1128/Iai.01291-15  0.8
2015 Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, ... ... Lacy DB, et al. Cloning and variation of ground state intestinal stem cells. Nature. 522: 173-8. PMID 26040716 DOI: 10.1038/Nature14484  0.8
2015 LaFrance ME, Farrow MA, Chandrasekaran R, Sheng J, Rubin DH, Lacy DB. Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: 7073-8. PMID 26038560 DOI: 10.1073/Pnas.1500791112  0.8
2014 Zhang Z, Park M, Tam J, Auger A, Beilhartz GL, Lacy DB, Melnyk RA. Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore. Proceedings of the National Academy of Sciences of the United States of America. 111: 3721-6. PMID 24567384 DOI: 10.1073/Pnas.1400680111  0.8
2013 Farrow MA, Chumbler NM, Lapierre LA, Franklin JL, Rutherford SA, Goldenring JR, Lacy DB. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proceedings of the National Academy of Sciences of the United States of America. 110: 18674-9. PMID 24167244 DOI: 10.1073/Pnas.1313658110  0.8
2013 Reyes-Robles T, Alonzo F, Kozhaya L, Lacy DB, Unutmaz D, Torres VJ. Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. Cell Host & Microbe. 14: 453-9. PMID 24139401 DOI: 10.1016/J.Chom.2013.09.005  0.8
2013 Benefield DA, Dessain SK, Shine N, Ohi MD, Lacy DB. Molecular assembly of botulinum neurotoxin progenitor complexes. Proceedings of the National Academy of Sciences of the United States of America. 110: 5630-5. PMID 23509303 DOI: 10.1073/Pnas.1222139110  0.8
2013 Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT. Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. Acs Chemical Biology. 8: 812-22. PMID 23343607 DOI: 10.1021/Cb300555N  0.8
2013 Chambers MG, Pyburn TM, González-Rivera C, Collier SE, Eli I, Yip CK, Takizawa Y, Lacy DB, Cover TL, Ohi MD. Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin. Journal of Molecular Biology. 425: 524-35. PMID 23178866 DOI: 10.1016/J.Jmb.2012.11.020  0.8
2012 Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Haslam DB, Haslam D, Goldenring JR, Lacy DB. Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. Plos Pathogens. 8: e1003072. PMID 23236283 DOI: 10.1371/Journal.Ppat.1003072  0.8
2012 Pruitt RN, Lacy DB. Toward a structural understanding of Clostridium difficile toxins A and B. Frontiers in Cellular and Infection Microbiology. 2: 28. PMID 22919620 DOI: 10.3389/Fcimb.2012.00028  0.8
2012 Pruitt RN, Chumbler NM, Rutherford SA, Farrow MA, Friedman DB, Spiller B, Lacy DB. Structural determinants of Clostridium difficile toxin A glucosyltransferase activity. The Journal of Biological Chemistry. 287: 8013-20. PMID 22267739 DOI: 10.1074/Jbc.M111.298414  0.8
2011 Mushrush DJ, Koteiche HA, Sammons MA, Link AJ, McHaourab HS, Lacy DB. Studies of the mechanistic details of the pH-dependent association of botulinum neurotoxin with membranes. The Journal of Biological Chemistry. 286: 27011-8. PMID 21652698 DOI: 10.1074/Jbc.M111.256982  0.8
2010 Gangwer KA, Shaffer CL, Suerbaum S, Lacy DB, Cover TL, Bordenstein SR. Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA. Journal of Bacteriology. 192: 6126-35. PMID 20870762 DOI: 10.1128/Jb.01081-10  0.8
2010 Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB. Structural organization of the functional domains of Clostridium difficile toxins A and B. Proceedings of the National Academy of Sciences of the United States of America. 107: 13467-72. PMID 20624955 DOI: 10.1073/Pnas.1002199107  0.8
2010 González-Rivera C, Gangwer KA, McClain MS, Eli IM, Chambers MG, Ohi MD, Lacy DB, Cover TL. Reconstitution of Helicobacter pylori VacA toxin from purified components. Biochemistry. 49: 5743-52. PMID 20527875 DOI: 10.1021/Bi100618G  0.8
2010 Schmitt J, Karalewitz A, Benefield DA, Mushrush DJ, Pruitt RN, Spiller BW, Barbieri JT, Lacy DB. Structural analysis of botulinum neurotoxin type G receptor binding . Biochemistry. 49: 5200-5. PMID 20507178 DOI: 10.1021/Bi100412V  0.8
2010 Ivie SE, McClain MS, Algood HM, Lacy DB, Cover TL. Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin. Bmc Microbiology. 10: 60. PMID 20178613 DOI: 10.1186/1471-2180-10-60  0.8
2009 Pruitt RN, Chagot B, Cover M, Chazin WJ, Spiller B, Lacy DB. Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A. The Journal of Biological Chemistry. 284: 21934-40. PMID 19553670 DOI: 10.1074/Jbc.M109.018929  0.8
2008 Fischer A, Mushrush DJ, Lacy DB, Montal M. Botulinum neurotoxin devoid of receptor binding domain translocates active protease. Plos Pathogens. 4: e1000245. PMID 19096517 DOI: 10.1371/Journal.Ppat.1000245  0.8
2008 Ivie SE, McClain MS, Torres VJ, Algood HM, Lacy DB, Yang R, Blanke SR, Cover TL. Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes. Infection and Immunity. 76: 2843-51. PMID 18443094 DOI: 10.1128/Iai.01664-07  0.8
2007 Gangwer KA, Mushrush DJ, Stauff DL, Spiller B, McClain MS, Cover TL, Lacy DB. Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain. Proceedings of the National Academy of Sciences of the United States of America. 104: 16293-8. PMID 17911250 DOI: 10.1073/Pnas.0707447104  0.8
2007 Scobie HM, Marlett JM, Rainey GJ, Lacy DB, Collier RJ, Young JA. Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation. Plos One. 2: e329. PMID 17389920 DOI: 10.1371/Journal.Pone.0000329  0.8
2006 Scobie HM, Wigelsworth DJ, Marlett JM, Thomas D, Rainey GJ, Lacy DB, Manchester M, Collier RJ, Young JA. Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. Plos Pathogens. 2: e111. PMID 17054395 DOI: 10.1371/Journal.Ppat.0020111  0.8
2006 Melnyk RA, Hewitt KM, Lacy DB, Lin HC, Gessner CR, Li S, Woods VL, Collier RJ. Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. The Journal of Biological Chemistry. 281: 1630-5. PMID 16293620 DOI: 10.1074/Jbc.M511164200  0.8
2005 Lacy DB, Lin HC, Melnyk RA, Schueler-Furman O, Reither L, Cunningham K, Baker D, Collier RJ. A model of anthrax toxin lethal factor bound to protective antigen. Proceedings of the National Academy of Sciences of the United States of America. 102: 16409-14. PMID 16251269 DOI: 10.1073/Pnas.0508259102  0.8
2005 Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ. A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore. Science (New York, N.Y.). 309: 777-81. PMID 16051798 DOI: 10.1126/Science.1113380  0.8
2004 Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJ. Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proceedings of the National Academy of Sciences of the United States of America. 101: 13147-51. PMID 15326297 DOI: 10.1073/Pnas.0405405101  0.8
2004 Lacy DB, Wigelsworth DJ, Scobie HM, Young JA, Collier RJ. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proceedings of the National Academy of Sciences of the United States of America. 101: 6367-72. PMID 15079089 DOI: 10.1073/Pnas.0401506101  0.8
2004 Wigelsworth DJ, Krantz BA, Christensen KA, Lacy DB, Juris SJ, Collier RJ. Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. The Journal of Biological Chemistry. 279: 23349-56. PMID 15044490 DOI: 10.1074/Jbc.M401292200  0.8
2003 Mourez M, Yan M, Lacy DB, Dillon L, Bentsen L, Marpoe A, Maurin C, Hotze E, Wigelsworth D, Pimental RA, Ballard JD, Collier RJ, Tweten RK. Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13803-8. PMID 14623961 DOI: 10.1073/Pnas.2436299100  0.8
2002 Lacy DB, Collier RJ. Structure and function of anthrax toxin. Current Topics in Microbiology and Immunology. 271: 61-85. PMID 12224524 DOI: 10.1007/978-3-662-05767-4_4  0.8
2002 Mourez M, Lacy DB, Cunningham K, Legmann R, Sellman BR, Mogridge J, Collier RJ. 2001: a year of major advances in anthrax toxin research. Trends in Microbiology. 10: 287-93. PMID 12088665 DOI: 10.1016/S0966-842X(02)02369-7  0.8
2002 Cunningham K, Lacy DB, Mogridge J, Collier RJ. Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen. Proceedings of the National Academy of Sciences of the United States of America. 99: 7049-53. PMID 11997439 DOI: 10.1073/Pnas.062160399  0.8
2002 Mogridge J, Cunningham K, Lacy DB, Mourez M, Collier RJ. The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proceedings of the National Academy of Sciences of the United States of America. 99: 7045-8. PMID 11997437 DOI: 10.1073/Pnas.052160199  0.8
2002 Lacy DB, Mourez M, Fouassier A, Collier RJ. Mapping the anthrax protective antigen binding site on the lethal and edema factors. The Journal of Biological Chemistry. 277: 3006-10. PMID 11714723 DOI: 10.1074/Jbc.M109997200  0.8
2001 Pannifer AD, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna P, Liddington RC. Crystal structure of the anthrax lethal factor. Nature. 414: 229-33. PMID 11700563 DOI: 10.1038/N35101998  0.8
1999 Lacy DB, Stevens RC. Sequence homology and structural analysis of the clostridial neurotoxins. Journal of Molecular Biology. 291: 1091-104. PMID 10518945 DOI: 10.1006/Jmbi.1999.2945  0.8
1998 Lacy DB, Stevens RC. Unraveling the structures and modes of action of bacterial toxins. Current Opinion in Structural Biology. 8: 778-84. PMID 9914258 DOI: 10.1016/S0959-440X(98)80098-5  0.8
1998 Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC. Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nature Structural Biology. 5: 898-902. PMID 9783750 DOI: 10.1038/2338  0.8
1997 Lacy DB, Stevens RC. Recombinant expression and purification of the botulinum neurotoxin type A translocation domain. Protein Expression and Purification. 11: 195-200. PMID 9367816 DOI: 10.1006/Prep.1997.0772  0.8
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